Abstract: A liquid medication with reduced bitterness containing a drug active and polyquaternium-2, polyquaternium-17, and/or polyquaternium-18.

Abstract: In alternative embodiments, provided are pharmaceutical compositions, formulations, kits and other products of manufacture, comprising a sterile hydrogel comprising a hydrogel material and active ingredients including one or a plurality of compositions or compounds, which may comprise: a biologic, a drug or an immunostimulating agent or reagent; an antigen or an immunogen, or a plurality of antigens or immunogens; an anticancer agent or reagent, or any combination thereof.

Abstract: Pharmaceutical complexes composed of drug molecules entrapped in cyclodextrin-based MOFs (CD-MOFs) are provided. Pharmaceutical tablets incorporating crystals of the pharmaceutical complexes for oral administration to a patient are also provided. In addition, methods of making the pharmaceutical complexes using anion-exchange reactions and methods of making the pharmaceutical complexes based on the co-crystallization of the drug molecules with cyclodextrin are provided. The pharmaceutical complexes include a CD-MOF and deprotonated drug anions associated with alkali metal cations in the CD-MOF superstructure.

Abstract: The present invention relates to stable low-salt aqueous formulations of particles comprising a polycation, preferably protamine, and RNA, which formulations are preferably isotonic, to pharmaceutical compositions or kits comprising such formulations and to their use in medicine. It further relates to methods for preparing the formulations of the invention and to methods for physically stabilizing particles comprising a polycation, preferably protamine, and RNA.

Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.

Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

Abstract: A synthetic calcium phosphate-based biomedical material comprising gadolinium. The material may comprises a compound having the general chemical formula: Ca10?yGdy(PO4)6?x(SiO4)x(OH)2?c+y where 0<x<1.3 and 0<y<1.3.

Abstract: Nanoparticles for use as magnetic resonance imaging contrast agents are described. The nanoparticles are made up of a polymeric support and a manganese-oxo or manganese-iron-oxo cluster having magnetic properties suitable of a contrast agent. The manganese-oxo clusters may be Mn-12 clusters, which have known characteristics of a single molecule magnet. The polymer support may form a core particle which is coated by the clusters, or the clusters may be dispersed within the polymeric agent.

Abstract: A method for decontaminating caps (2) or necks of containers by electron bombardment, the method including: an operation of the passage or positioning of the caps (2) or necks of containers in front of an electron bombardment window (8), the opening of the caps (2) or necks of the containers facing the window (8); and an operation of electron bombardment of the caps (2) or necks of the containers, during the passage or positioning of the caps or necks of the containers in front of the window (8); the bombardment being carried out by way of a pulsed electric field including a series of electrical pulses of determined frequency, duration and intensity.

Abstract: A portable medical sanitation device includes a power source, a solid-state UV light source for outputting UV light (e.g. within the UV-C band), a controller for directing the plurality of solid-state UV light sources to output UV light, a sterilization chamber comprising a cavity having side-walls having the solid-state UV light source coupled thereto, wherein the sterilization chamber is configured to receive UV light from the plurality of solid-state UV light sources, and wherein the side-walls are configured to reflect UV light incident thereto, and a housing configured to contain the power source, the plurality of solid-state UV light sources, the controller and the sterilization chamber.

Abstract: Stable, aqueous solutions of chlorine dioxide and methods for producing stable, aqueous solutions of chlorine dioxide are disclosed. Generally, the chlorine dioxide solutions of the invention are aqueous solutions containing about 1000 ppm by weight or less of total impurities and/or 10 ppm or less of manganese and iron combined. The aqueous chlorine dioxide solutions are storage stable for at least 90 days at 25° C. and maintain at least 75% of the initial chlorine dioxide concentration. Methods of preparing, using and transporting the chlorine dioxide solutions are also disclosed.

Abstract: The present invention relates to an aroma burner comprising a burner body and a base; the upper end in the burner body is provided with a ring slot internally provided with microcrystal glass panels; the microcrystal glass panels are affixed on the edge of the slot of the burner body through silica gel; a wax storage bowl is disposed on the upper ends of the microcrystal glass panels; a plurality of aroma wax blocks are placed in the wax storage bowl; the lower ends of the microcrystal glass panels are applied with a silver paste coating; the base is provided with a power socket; the base is also provided with a transparent plastic box; the plastic box is provided with a micro-control circuit board; the circuit board is connected with the silver paste coating and the power switch.

Abstract: A fragrance dispenser for emitting fragrance into an airstream impinging on an air filter, the dispenser having a receptacle with an open end that faces toward the air filter and that has a porous diffuser layer occlusively overlying the open end of the receptacle.

Abstract: A method potentiating antimicrobial silver materials against pathogens. The method includes the steps of: providing an antimicrobial silver material to an article to be treated; providing oxygen to the article at greater than atmospheric concentration in the presence of the antimicrobial silver so the antimicrobial silver material provides greater microbial kill than antimicrobial silver material alone. The method encompasses providing an antimicrobial silver material and providing oxygen at greater than atmospheric concentration to a wound. Devices and compositions for carrying out the method and processes for making such devices and compositions are also disclosed.

Abstract: A method of sealing a durotomy from which cerebrospinal fluid is leaking. A durotomy sealant dressing is prepared by applying an active agent to a dextran base. The durotomy sealant dressing is applied to a durotomy. At least a portion of the durotomy sealant dressing dissolves. The durotomy is sealed with the dissolved durotomy sealant dressing to substantially prevent cerebrospinal fluid from flowing through the durotomy.

Abstract: Disclosed are medical devices, e.g., surgical sutures, surgical staples, surgical pads, surgical meshes, surgical scaffolds etc., and methods of use at a wound in a patient to facilitate the rapid healing of the tissue at the situs of the wound with minimal fibrous tissue formation. The devices are arranged to be brought into engagement with tissue adjacent the wound to close the wound and include a core formed of a piezo-electric material and an outer layer covering the core. The outer layer is platelet derived growth factors. The methods of use of the devices also include applying a local molecular energy production agent to the wound and irradiating the wound with a pulsed infra-red laser beam.

Abstract: Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.

Abstract: Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.

Abstract: Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.

Abstract: The present invention relates to a parenteral composition for maintaining the efficacy of a filler for a long time, containing a collagen hydrolysate as an active ingredient. The composition, according to the present invention, can maintain the efficacy of a hyaluronic acid filler for a longer time, thereby enabling the effect thereof to be maintained irrespective of a smaller frequency of filler operations, and thus there is an advantage of also reducing skin irritation. In addition, there is an advantage of enabling an immediate effect since an administration method is simple as a parenteral administration and enables direct penetration into the skin.

Abstract: An apparatus and method for the production of substitute skin that advantageously reduces the amount of donor dermal cells needed from non-wound areas of a patient having a wound to be auto-grafted is reduced by using all of the harvested skin cells. A 3D printer is used to construct a wound graft product from the harvested skin cells without wasting any of the harvested skin cells. In a case of an irregularly shaped wound, wastage of harvested skin associated with trimming is avoided.

Abstract: An apparatus and method for the production of substitute skin that advantageously reduces the amount of donor dermal cells needed from non-wound areas of a patient having a wound to be auto-grafted is reduced by using all of the harvested skin cells. A 3D printer is used to construct a wound graft product from the harvested skin cells without wasting any of the harvested skin cells. In a case of an irregularly shaped wound, wastage of harvested skin associated with trimming is avoided.

Abstract: Bone matrix compositions having nanoscale textured surfaces and methods for their production are provided. In some embodiments, bone matrix is prepared for implantation and retains nanoscale textured surfaces. In other embodiments, nanostructures are imparted to bone matrix wherein collagen fibrils on the surface of the bone matrix have been compromised, thus imparting a nanoscale textured surface to the bone matrix. Generally, these methods may be applied to mineralized or demineralized bone including partially or surface demineralized bone.

Abstract: A decellularized small particle tissue derived from blood-laden tissue which has been decellularized at an acid pH in the presence of blood to remove at least a portion of the cellular material therefrom. The product contains conserved beneficial proteins originally present in the blood-laden starting tissue such as fibronectin, laminin, and elastin and comprises particle sizes in the range from 200 microns to 10 Kilo Daltons. A recycling method of filtration is taught to produce various forms of the product.

Abstract: An apparatus and method for hydrating a particulate biomaterial with a liquid biomaterial includes a vacuum device and a valve for withdrawing a gas from the particulate biomaterial and introducing the liquid biomaterial. The valve includes a hub, a valve body, a particulate port, a vacuum port, and a liquid port. The valve body selectively moves between first and second positions. The valve body at least partially defines a first passage and a second passage. The particulate port, the vacuum port, and the liquid port are each configured to fluidly connect to a particulate container, the vacuum device, and the liquid container, respectively. In the first position, the first passage fluidly connects the vacuum port to the particulate port for withdrawing the gas from the particulate container. In the second position, the second passage fluidly connects the liquid port to the particulate port for hydrating the particulate biomaterial.

Abstract: Compositions and methods for promoting tissue regeneration with gonad-derived stem cell side population cells are provided.

Abstract: Implantable devices comprising a scaffold, cells, and/or therapeutic molecules are provided. Uses include inhibition of pathological immunity, elaboration of therapeutic growth factors, and immune augmentation. The implantable device may contain a porous substrate structure to which therapeutic cells are adherent, which can be implanted and explanted from a patient. In another embodiment, a medical device includes a porous substrate seeded with therapeutic cells, said device comprising of an additional layer allowing free exchange of molecules without cell escape. Said medical device is seeded with thymic medullary epithelial cells or progenitors of said thymic medullary epithelial cells. In conditions where tolerance to alloreactive donor cells is desired, the thymic medullary epithelial cells or progenitors thereof are derived from recipient cells.

Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.

Abstract: A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

Abstract: A multilayer sheet can be used in vivo or in an environment in which moisture is adhered, an integrated sheet including the multilayer sheet and a base material, and methods for producing the same. The multilayer sheet has one or more layers from each of a layer (A) composed of sparingly water-soluble polymer and a fiber layer (B) composed of water-soluble polymer are laminated, and at least one of outermost layers is the above-described layer (A) composed of sparingly water-soluble polymer. The time taken from dropping of water onto a surface of the outermost layer of the above-described layer (A) composed of sparingly water-soluble polymer to dissolution of the other outermost layer is 10 seconds to 5 minutes.

Abstract: The present invention relates generally to improved systems and methods for removing undesirable material residing in vessels. More specifically, the present invention relates to systems and methods for using at least one cannula to remove to remove substantially en bloc, from a site of obstruction or interest, undesirable material without fragmentation and without excessive fluid loss.

Abstract: A system, method and apparatus for notifying a surgeon of an occlusion in an ocular surgical apparatus are disclosed herein. Through operation of a handpiece of the surgical apparatus, the handpiece may become blocked or occluded. An occlusion detector is configured to sense the occlusion in the handpiece, and an occlusion signal is generated. A control module is provided to send an occlusion warning signal to a foot pedal of the surgical apparatus, where a tactile notification is provided to a user of the apparatus that an occlusion has occurred.

Abstract: A system for synchronizing one or more breast-pumping sessions of an individual (such as a mother) and milk consumption by a second individual (such as a baby or infant) is described. In particular, based on measurements of a volume of the collected milk as a function of time and received information specifying milk consumption by the second individual as a function of time, a control circuit may determine a need for milk. Then, the control circuit may provide feedback based on the determined need for milk that synchronizes the one or more breast-pumping sessions and the milk consumption. For example, the feedback may alert the individual to initiate a breast-pumping session and/or may provide a signal to a breast pump that initiates a breast-pumping session.

Abstract: Improved devices and methods for the expression of milk from a breast are disclosed herein. A device for expressing breast milk may comprise a breast interface including a flange configured to engage a breast and fluidly seal thereagainst, and an actuatable assembly operably coupled to the breast interface and configured to apply vacuum pressure at the breast interface. The breast interface may be configured to apply anterior compression to an anterior portion of the breast when the actuatable assembly is actuated. The flange may be configured to apply posterior compression to a posterior portion of the breast when the actuatable assembly is actuated. The posterior compression can help improve the efficiency of milk expression by reducing the retrograde flow of milk.

Abstract: Heart support device for circulatory assistance, with an internal member (6) to be disposed inside a heart lumen (13) and having a dynamic volume body. The internal member (6) has a substantially stiff wall strengthening portion (8) arranged to engage an inner wall surface (12a) of the heart (10) in operation and a dynamic member (9) that is inflatable to assist pumping action of the heart (10).

Abstract: A ventricular assist device is disclosed. The ventricular assist device may include a centrifugal pump and a controller. The controller may be configured to cause the centrifugal pump to operate at a first speed above a predetermined flow rate. The controller may also be configured to cause the centrifugal pump to operate at a second speed below the predetermined flow rate, wherein the predetermined flowrate is indicative of a crossover point between systole and diastole phases of a person's cardiac cycle.

Abstract: Systems, apparatuses, and methods are disclosed for optimizing management of one or more implanted artificial heart pumps. An example method includes wirelessly retrieving, via one or more portable diagnostic devices, data regarding the one or more implanted artificial heart pumps. The example method further includes analyzing, by a server device, performance characteristics of the one or more implanted artificial heart pumps based on the retrieved data. The example method further includes causing rendering of the performance characteristics. Corresponding apparatuses and computer program products are contemplated.

Abstract: Thermal management solutions for wireless power transfer systems are provided, which may include any number of features. In one embodiment, an implantable wireless power receiver includes at least one thermal layer disposed on an interior surface of the receiver configured to conduct heat from a central portion of the receiver towards edges of the receiver. The thermal layer can comprise, for example, a copper layer or a ceramic layer embedded in an acrylic polymer matrix. In some embodiments, a plurality of thermal channels can be formed within the receiver to transport heat from central regions of the receiver towards edges of the receiver via free convection. In yet another embodiment, a fluid pipe can be connected to the receiver and be configured to carry heat from the receiver to a location remote from the receiver. Methods of use are also provided.

Abstract: A tele-care management system for peritoneal dialysis (PD) includes at least a container, a holder, a removable detection device and a mobile device. The container is for placing effluent fluid of peritoneal dialysis. The holder is for placing the container. The removable detection device includes a detection unit, a processor and a communication interface, wherein the processor detects the turbidity and the chrominance of the effluent fluid and performs a quantitative analysis on the effluent fluid, and generates a turbidity prediction value based on the detection result of the detection unit. The processor respectively calculates first and second turbidity values, which correspond to first and second turbidity respectively, for the effluent fluid according to first and second algorithms and selects one from the first and second turbidity values to generate the turbidity prediction value based on a predetermined threshold value sent to a mobile device for further processing.

Abstract: Filter assemblies are processing biological fluid, such as blood or a blood component containing leukocytes. The filter assemblies include a flexible housing with first and second walls. A filtration medium and a support member are at least partially positioned between the walls of the housing, with a seal joining the walls of the housing, the filtration medium, and the support member. The filter assemblies may further include a pre-filter and/or a post-filter positioned between the walls of the housing. If provided, the pre- and post-filter may be positioned on opposite walls of the filtration medium, with the post-filter being a mesh positioned between the filtration medium and one of the walls of the housing or within an opening defined by the support member. A seal of the filter assembly may pass through the filtration medium, with the filtration medium being substantially omitted in a section of the seal.

Abstract: Systems, methods, and compositions for removing organophosphate toxins from blood are disclosed herein. The compositions include a lipid-based capture particle that displays BChE that binds to the toxin. The methods include acoustically separating toxins bound to lipid-based capture particles from blood factors of whole blood.

Abstract: A blood treatment cassette having a cassette body, designed as a hard part, and a film, wherein the film is connected with the hard part and covers the hard part at least partially, wherein the hard part comprises at least one valve base of a valve and wherein the valve is embodied to take, in addition to a first, open position of the valve in which the valve base and the section of the film that is arranged above it do not touch each other, a second, closed position of the valve when applying force on the section of the film in which the valve base and the section of the film touch each other.

Abstract: A system and method for removing gas bubbles from fluid. An active filter apparatus forces the bubbles to the center of the filter, while a pump supplies fluid to the filter.

Abstract: The invention relates to a device A for monitoring a vessel opening for an extracorporeal blood treatment device B with an extracorporeal blood circulation (I), which has an arterial blood line (20) with an arterial cannula (19) and a venous blood line (21) with a venous cannula (22). Moreover, the invention relates to an arrangement with a device A for monitoring a vessel opening and an extracorporeal blood treatment device B, and a method for monitoring a vessel opening during an extracorporeal blood treatment. The monitoring device A comprises a sensor (1) for detecting at least one physical variable, which is characteristic for the state of the vessel opening, and an evaluation apparatus (7), connected to the sensor (1) by way of a connection cable (6), for producing signals characteristic for the state of the vessel opening. The evaluation apparatus (7) has a data transmission unit (38) for establishing a wireless connection between the evaluation apparatus (7) and the blood treatment device B.

Abstract: The present invention relates to a blood oxygenator device comprising an equilibration-measurement unit for determining the concentration of an inhalational anesthetic in the blood of a patient, a method of manufacturing such a blood oxygenator device and methods of using such a blood oxygenator device.

Abstract: Disclosed is a medical injection device (1) comprising a needle assembly (20) having a cannula (21) and a telescopic shield (30) for covering the distal tip (23) in a no use situation. The telescopic shield further carries a cleaning reservoir (40) for cleaning the needle cannula between two subsequent injections. The cleaning reservoir is provided with an opening (43) connecting to an overflow reservoir (51/55) such that the cleaning liquid contained in the cleaning reservoir can retract and expand upon temperature changes and does not enter the needle lumen instead. In one example, the overflow reservoir is formed as a channel (51).

Abstract: A delivery system for the effective, reliable and foolproof delivery of controlled amounts of a medical grade gas to a patient includes a compressed gas unit composed of a vacuum sealed bag to which is secured at least one compressed gas cartridge and a multi-part valve delivery system.

Abstract: The present invention relates to a workpiece carrier for transporting and/or storing components of a drug delivery device, comprising: an array of accommodating recesses extending in a first lateral plane (x, y) and being adapted to receive at least one component of the drug delivery device, at least one stack forming structure adapted to mate with a corresponding stack forming structure of another workpiece carrier for mutually aligning workpiece carriers when stacked on one another, wherein the center of the at least one stack forming structure is arranged laterally offset with respect to the center of the array of accommodating recesses in at least one lateral direction, and wherein the stack forming structure comprises a surrounding edge comprising at least in sections a corrugated or undulated structure.