Abstract: The present invention relates to a method for assessing whether a patient suffers from cancer, such as hepatocellular carcinoma, or is prone to suffering from cancer, such as hepatocellular carcinoma, wherein said method comprises determining the amount of soluble AXL in a sample from the patient. The patient is assessed to suffer from cancer or to be prone to suffering from cancer when the amount of soluble AXL is increased in comparison to a control. The present invention relates to the use of soluble AXL for assessing whether a patient suffers from cancer, such as hepatocellular carcinoma, or is prone to suffering from cancer, such as hepatocellular carcinoma. Also a kit for use in the methods of the present invention is provided.

Abstract: The present invention relates to diagnostic, prognostic and clinical methods of distinguishing high-risk IPMN from more benign IPMN as well as high-grade PanIN and PDAC from low-grade PanIN with moderate sensitivity and very high specificity using Das-1 and related antibodies.

Abstract: Disclosed are methods of identifying tumor-derived exosomes as an early cancer diagnostic, as well as for staging, assessing progression and assessing therapy of cancer.

Abstract: The present invention relates to extracellular microvesicles biomarkers for determining the tumour transformation status or presence of a tumour in a subject, and to the uses of such biomarkers and to diagnostics methods using such biomarkers. In particular, the methods and uses of the invention involve isolation of TM9SF4-positive extracellular vesicles and detection of the expression of a second biomarker, preferably selected from the group consisting of CD9 protein, miR-21 and RNU6.

Abstract: Provided is a method of assaying for an analyte, including combining a test sample having the analyte, with a calibration sample having at least two different aliquots of the analyte, each aliquot having a different known quantity of the analyte. The test sample and each aliquot are differentially labeled with one or more isobaric mass labels each with a mass spectrometrically distinct mass marker group, such that the test sample and each aliquot of the calibration sample can be distinguished by mass spectrometry. The method further includes determining by mass spectrometry the quantity of analyte in the test sample and in each aliquot, and calibrating the quantity of analyte in the test sample against known and determined quantities of analytes in the aliquots.

Abstract: Provided herein are methods, systems, devices, and computer-readable storage media for selecting a detection area for a well (e.g., as part of an assay plate) comprising a plurality of encoded microcarriers. In some aspects, selecting the detection area includes obtaining one or more images of the well; calculating a center of the well according to a two-dimensional coordinate system; assigning a position, according to the two-dimensional coordinate system, of a first encoded microcarrier from the plurality; determining whether a distance between the position of the first encoded microcarrier and the center of the well according to the two-dimensional coordinate system exceeds a threshold distance; and including in the detection area one or more microcarriers whose distance from the center of the well does not exceed the threshold distance, while excluding those whose distance from the center of the well exceeds the threshold.

Abstract: Provided are a method and an apparatus for coordinating inter-cell interference. A user equipment receives from a serving cell information on a downlink timing offset between an interfering cell and an interfered cell and a limited resource measurement, and applies the downlink timing offset to perform measurement using a radio resource indicated for the limited resource measurement, thereby allowing the user equipment to be provided services through the radio resource which substantially mitigates interference, and enhancing connectivity with a network.

Abstract: The present invention relates to reversed phase high-performance liquid chromatography (HPLC) methods useful for the characterisation of glatiramer acetate or similar polypeptide mixtures. The method described herein can distinguish glatiramer acetate from non-conforming copolymers and may be used to choose batches of glatiramer acetate suitable for pharmaceutical use.

Abstract: The disclosure provides biomarker panels, methods and kits for determining the probability for preterm birth in a pregnant female. The present disclosure is based, in part, on the discovery that certain proteins and peptides in biological samples obtained from a pregnant female are differentially expressed in pregnant females that have an increased risk of developing in the future or presently suffering from preterm birth relative to matched controls. The present disclosure is further based, in part, on the unexepected discovery that panels combining one or more of these proteins and peptides can be utilized in methods of determining the probability for preterm birth in a pregnant female with relatively high sensitivity and specificity. These proteins and peptides dislosed herein serve as biomarkers for classifying test samples, predicting a probability of preterm birth, monitoring of progress of preterm birth in a pregnant female, either individually or in a panel of biomarkers.

Abstract: The present invention relates to a set of two or more mass labels, wherein each mass label comprises the formula: X-L-M-Re wherein X is a reporter moiety having an exact mass, L is a bond cleavable by collision in a mass spectrometer, M is a mass modifier, and Re is a) a reactive functionality for attaching the mass label to an analyte or b) the analyte, wherein each mass label in the set has an integer mass, wherein each mass label in the set has the same integer mass, and wherein the set comprises two or more subsets of mass labels, each subset comprising one, two or more mass labels, and wherein, when the subset comprises two or more mass labels, the exact mass of the reporter moiety X of each mass label in the subset is different from the exact mass of the reporter moiety X of the mass labels in the same subset and in all other subsets, and wherein each mass label is distinguishable by mass spectrometry.

Abstract: Provided are artificially synthesized modified mono-methylated lysines and modified mono-methylated lysine derivatized polypeptides. Also provided is an antibody produced by using this modified mono-methylated lysine and modified monomethylated lysine derivatized polypeptide as an antigen, the antibody can be used in recognizing and enriching the modified polypeptide after the lysine mono-methylated polypeptide being derivatized in vitro. Also provided are a preparation method of said antibody, a method for identifying and quantifying the lysine mono-methylated modified substrate in cell or tissue by using proteomics approach of affinity enrichment for specific antibody and mass spectrometry.

Abstract: The present disclosure relates methods for identifying antibodies that binds to an antigen in primates.

Abstract: Provided herein are methods that include (i) determining a level of soluble ST2 in a biological sample from a subject, (i) comparing the level of soluble ST2 in the biological sample to a reference level of soluble ST2 (e.g., a level of soluble ST2 in the subject at an earlier time point), and (iii) selecting, implanting, replacing, or reprogramming an implanted cardiac device, e.g., an ICD, CRT, or CRT-D device, for a subject having an elevated level of soluble ST2 in the biological sample compared to the reference level of soluble ST2, or selecting a subject for participation in, or stratifying a subject participating in, a clinical study of a treatment for reducing the risk of a ventricular tachyarrhythmia (VTA) event. Also provided are methods for evaluating the risk of a VTA event in a subject. Also provided are kits for performing any of these methods.

Abstract: Provided is a test method for the assessment of the necessity of renal biopsy in a subject to be tested, who is suspected of having a renal disease. Specifically provided are a test method for a renal disease, including using urinary podocalyxin and one or more additional markers in combination, and a test reagent for use in the test method and a test reagent kit for use in the test method. The present invention allows the discrimination of a poor prognosis group even for poor prognosis cases with no overt findings in a conventional test method, and thus allows the assessment of a renal disease, the assessment of the necessity of renal biopsy, prognostic prediction, and the like to be performed exactly.

Abstract: Provided is a test method for the detection of diabetic nephropathy at an early stage as compared to a conventional method. Specifically provided are: a test method for diabetic nephropathy, including detecting urinary podocalyxin; the test method, further including assessing diabetic nephropathy at at least Stage I; a test reagent for use in the test method; and a test reagent kit for use in the test method. The present invention is based on a finding that urinary podocalyxin reflects the development and condition of diabetic nephropathy with high sensitivity at an early stage as compared to urinary albumin.

Abstract: Proteins that are differentially expressed or elevated in tissue and biofluids after central nervous system injuries are described. Elevated or reduced levels of the proteins, alone or in various combinations or ratios, can be used to assess severity of central nervous system injury (CNS injury) including traumatic brain injury (TBI), traumatic spinal cord injury (SCI) and chronic traumatic encephalopathy (CTE). Time course measurements post CNS-injury of these proteins can be used to monitor progress or recovery over periods up to several months. Differentiation of acute, subacute and chronic injury can be diagnosed by comparing the protein levels in CNS-injury patients at days 1-3, day 4-10 with levels at day 30-180 in comparison with normal controls.

Abstract: The invention provides an analytical process for analysing the presence of at least one aggregated conformation prion protein in a sample of body fluid or a sample of tissue and uses the dependency of the amplification of the aggregated conformation on the shear-force intensity applied to the native conformation prion protein, which is also dependent on the specific seed present in the admixture with native conformation prion protein, for specifically analysing for the presence of an aggregated conformation prion protein in the sample.

Abstract: The present invention encompasses a method for determining A? turnover in blood.

Abstract: A method for sorting nucleated red blood cells, the method includes: selecting a candidate cell of nucleated red blood cells in accordance with shapes of cells; setting a search range including the candidate cell and selecting a white blood cell within the search range; defining that the candidate cell is a nucleated red blood cell through comparison of spectral characteristics of hemoglobin between the candidate cell and the white blood cell; and sorting the nucleated red blood cells into mother-derived nucleated red blood cells or fetus-derived nucleated red blood cells through comparison of an allele contained in the nucleated red blood cell after the defining of the nucleated red blood cell with an allele contained in a white blood cell which has not been selected in the selecting of the candidate cell or in the white blood cell selected in the selecting of the white blood cell.

Abstract: The present invention is in the field of automated analyzers and relates to a method for transferring a liquid volume in an analyzer. This involves the tip of a pipetting needle touching a wall of a tilted reaction vessel during the dispensing of liquid.

Abstract: Systems and methods are described for a non-contact method for positioning a tip of an object. A light beam of known dimensions is projected and a position of the tip of the object relative to the light beam is adjusted. Light scatter indicative of the tip of the object being positioned within the dimensions of the light beam is detected and a position of the tip of the object is determined based at least in part on the known dimensions of the light beam and the detected light scatter.

Abstract: One embodiment provides a method, including: receiving, at electronic device, data from a wearable device; detecting that the received data relate to a sensor event of at least one sensor of the electronic device, the sensor event being generated and operable to effect an operation of the electronic device via an operating system of the electronic device; and effecting the operation of the electronic device based on the sensor event via the operating system. Other aspects are described and claimed.

Abstract: In a method for open loop operation of a capacitive accelerometer, a first mode of operation comprises electrically measuring a deflection of a proof mass (204) from the null position under an applied acceleration using a pickoff amplifier (206) set to a reference voltage Vcm. A second mode of operation comprises applying electrostatic forces in order to cause the proof mass (204) to deflect from the null position, and electrically measuring the forced deflection so caused. In the second mode of operation the pickoff amplifier (206) has its input (211) switched from Vcm to Vss, using a reference control circuit (209), so that drive amplifiers (210) can apply different voltages Vdd to the proof mass (204) and associated fixed electrodes (202).

Abstract: A communication system for a vehicle comprises a mechanism for sensing a motion status of a vehicle, a control device, plurality of data acquisition sensors, and one or more alerting device activation circuits. The communication system is customizable with the plurality of data acquisition sensors and one or more alerting device activation circuits based upon the needs of the vehicle.

Abstract: The invention is directed at a method of positioning a carrier on a flat surface using an positioning member, wherein the carrier comprises an upper part and a base which are connected to each other such as to be arranged remote from each other, wherein the positioning member is arranged between the base and the upper part such that the base is located at an opposite side of the positioning member with respect to the upper part of the carrier, the upper part resting on the positioning member prior to placing of the carrier onto the flat surface, wherein the upper part comprises three engagement elements, and wherein the positioning member comprises a support surface for receiving the three engagement elements of the upper part, said support surface including a plurality of sockets forming a kinematic mount for said three engagement elements, wherein the base comprises three landing elements, each landing element being associated with a respective one of the three engagement elements, and the method comprising

Abstract: A system has a chip mounting board and a docking board. The chip mounting board can be loaded with test samples in a low voltage environment and can then be transported to a high voltage environment. The chip mounting board can be connected to the docking board and allows high voltage testing of multiple samples in parallel. The chip mounting board can then be disconnected from the docking board and transported back to a low voltage environment to unload the tested samples.

Abstract: A test socket for facilitating testing of a device under test (DUT) includes a holder comprising a mounting structure for attaching the holder to other components of the socket and a floating nest structure in which the DUT can be disposed. The floating nest structure can have a seat cavity sized and shaped to receive and hold the DUT such that at least some of the DUT terminals are in contact with corresponding contacts of a test board while the test socket is attached to the test board. A flexure located laterally between the mounting structure and the floating nest structure and can allow the nest structure to move relative to the mounting structure and thus float.

Abstract: A probe system for facilitating inspection of a device under test comprising a plurality of panels, the probe system incorporating: a configurable universal probe bar comprising a plurality of probe blocks, the plurality of probe blocks comprising a plurality of probe pins positioned to simultaneously electrically engage a plurality of cell contact pads of the plurality of panels of the device under test to deliver a plurality of electrical test signals; and an alignment system configured to achieve an alignment of the plurality of probe pins with the plurality of the cell contact pads of the plurality of panels of the device under test.

Abstract: An electronic test equipment is adapted to test an electronic component. The electronic component has a circuit body and a plurality of connectors that are electrically connected to the circuit body. The electronic test equipment includes a metallic test seat and a plurality of spring probes. The metallic test seat is adapted to support the circuit body thereon, and is formed with a plurality of spaced-apart probe holes extending therethrough and possessing diameters that are substantially the same. Each of the probe holes is adapted to receive a corresponding one of the connectors. The spring probes are respectively and entirely positioned within the probe holes, and are adapted to electrically contact the connectors.

Abstract: A probe guide plate includes: a silicon substrate including one surface and the other surface opposite to the one surface; a through hole formed through the silicon substrate to extend from the one surface of the silicon substrate to the other surface of the silicon substrate; a silicon oxide layer formed on the one surface of the silicon substrate, the other surface of the silicon substrate, and an inner wall surface of the through hole; and a protective insulating layer formed on the silicon oxide layer. The protective insulating layer is formed on at least one of the one surface and the other surface of the silicon substrate via the silicon oxide layer, and partially formed on the inner wall surface of the through hole via the silicon oxide layer.

Abstract: A probe card for use in electrical testing of a device under test includes a mother substrate, a multilayer circuit board mounted on one main surface of the mother substrate, an outer electrode on the mother substrate, a coupling electrode on the main surface of the multilayer circuit board opposite the mother substrate to which a probe pin for supplying power to the device under test is connected, a power line PL coupling the outer electrode and the coupling electrode together, and a blowout portion including fuse wiring, the fuse wiring inserted in the power line PL and having a smaller current capacity than the power line PL. The power line PL has an exposed portion that is exposed on the surface of the multilayer circuit board, and the blowout portion is in the exposed portion of the power line PL.

Abstract: Current flowing through an inductor in response to a pulse width modulation (PWM) control signal is sensed to generate a sensed current. The sensed current is processed over one or more PWM cycles of the PWM control signal to generate an output signal indicative of average inductor current. This processing may include charging and discharging a capacitor at different rates dependent on the sense current, with the detection of capacitor discharge triggering a sampling of a voltage dependent on the sensed current that is indicative of average inductor current. The processing may include using the sensed to current to generate a first charge voltage associated with minimum inductor current and a second charge voltage associated with maximum inductor current, and then averaging the first and second charge voltages to generate an output signal indicative of average inductor current.

Abstract: A current sensor of Rogowski type including two layers of coils surrounding a current conductor, each layer of coils including a plurality of windings wound on a plurality of axes forming the contour of polygons of identical forms, arranged on parallel planes, and placed facing one another such that each corner zone of the first polygon is situated facing a corresponding corner zone of the second polygon and such that, in each corner zone, turns of the winding of the first layer of coils have different orientations from those of the turns of the winding of the second layer of coils in the facing corner zone.

Abstract: A measuring apparatus is provided for electrical signals. The measuring apparatus includes an analog-to-digital (A/D) converter configured to A/D-convert an analog signal to be measured, and an integrator configured to perform integration time processing for a plurality of digital values output from the A/D converter based on an integration time. The integrator is configured to output a plurality of measured values obtained by the integration time processing. A noise level calculation unit is configured to calculate a noise level of the analog signal to be measured from the plurality of measured values obtained by the integration time processing, and a display unit is configured to display noise levels corresponding to a plurality of integration times.

Abstract: A voltage stability monitoring device for monitoring the voltage stability of a system, the device including: an assumed change scenario calculation unit for predicting the output variation of a renewable energy connected to said system and calculating an assumed change time-series power flow state on the basis of said output variation; a time-series voltage stability calculation unit for calculating a node voltage change with respect to demand at each node of said system on the basis of said power flow state calculated by said assumed change scenario calculation unit and calculating a voltage stability indicating the relationship curve between said node voltage and reactive power; and a voltage stability improvement countermeasure search unit for determining a controlled device on which an assumed control is to be performed, according to said voltage stability calculated by said time-series voltage stability calculation unit.

Abstract: A source-measure unit (SMU) may be implemented with digital control loops and circuitry to digitally compensate for the impact of input bias current on current measurements. One or more buffers having well-defined characteristics with respect to certain parameters which may affect the current measurements may be used in the output signal path of the SMU where a shunt voltage developed across a current sense element is measured. For example, the buffers may conduct/develop respective input bias currents that change perceptibly and predictably with temperature. By measuring the temperature and adjusting a control voltage—which is used to develop the shunt voltage—according to the temperature measurements, the impact of the input bias current[s] on the current measurement[s] may be reduced to negligible levels and/or may be eliminated.

Abstract: Systems and methods are provided for estimating power breakdowns for a set of one or more appliances inside a building by exploiting a small number of power meters and data indicative of binary power states of individual appliances of such set. In one aspect, a breakdown estimation problem is solved within a tree configuration, and utilizing a single power meter and data indicative of binary power states of a plurality of appliances. Based at least in part on such solution, an estimation quality metric is derived. In another aspect, such metric can be exploited in a methodology for optimally placing additional power meters to increase the estimation certainty for individual appliances to a desired or intended level. Estimated power breakdown and energy breakdown—individually or collectively referred to as consumption breakdown—rely on measurements and numerical simulations, and can be evaluated in exemplary electrical network utilizing binary sensors.

Abstract: Disclosed herein are systems and methods for estimating a period and frequency of a waveform. In one embodiment, a system may comprise an input configured to receive a representation of the input waveform. A period determination subsystem may perform an iterative process to determine the variable period of the input waveform. The iterative process may comprise selection of an estimated window length, determination of an autocorrelation value based on the estimated window length, determination of an adjustment value to the window length to identify a maximum of the autocorrelation value; and determination of the variable period based on the window length associated with the maximum of the autocorrelation value. The period determination subsystem may perform the iterative process to track changes in the variable period of the input waveform. A control action subsystem may implement a control action based on the variable period of the input waveform.

Abstract: A method includes a) counting whole periods of a signal during a first period of a reference signal, b) repeating step a) for each period of the reference signal until a first duration is equal to a first quantity of periods of the reference signal, and c) determining a first average of the whole periods. The method also includes repeating at least one of steps a) to c) and at each repetition shifting a start of the counting of step a) by at least one period of the reference signal, and in steps b) and c) accounting for whole periods of the signal already counted during the at least one preceding group of steps a) and b). The method includes determining a second average of the first averages, and determining the frequency of the signal from the second average and the frequency of the reference signal.

Abstract: This disclosure is focused upon electrostatic discharge (ESD) control programs and more particularly an ESD testing device that performs electrostatic discharge (ESD) device efficacy verification in real time as it is being used. The results in some embodiments can be recorded for an ESD auditing program. The real time verification of the calibration of the unit includes circuitry for verification of the accuracy of the ESD device. The unit also includes a conically shaped guide to assist a user in plugging their wrist strap band connector into the device and also prevents a user from bypassing the testing unit by inserting digits into the ESD testing device rather than the wrist strap band connector.

Abstract: Various methods and systems are provided for an electrical testing apparatus for an electrical panel and associated wiring harness. In one embodiment, an electrical testing apparatus includes a common housing; a first connector tethered to the housing via a first plurality of wires extending away from and coupled within the housing, where the first connector is adapted to connect to an electrical panel; a second connector mounted to the housing and adapted to connect to a wiring harness of the electrical panel, the wiring harness including a second plurality of wires; and a third connector mounted to the housing and including a plurality of test points for testing an electrical signal passing through each wire of the second plurality of wires.

Abstract: A method for modeling cable loss is described. The method includes receiving a measurement of reverse power and forward power at a radio frequency (RF) generator. The method further includes computing theoretical power delivered to a matching network as a difference between the forward power and the reverse power and calculating a ratio of the reverse power to the forward power to generate an RF power reflection ratio. The method further includes identifying a cable power attenuation fraction based on a frequency of the RF generator and calculating a cable power loss as a function of the RF power reflection ratio, the cable power attenuation fraction, and the theoretical power. The method includes calculating actual power to be delivered to the impedance matching network based on the theoretical power and the cable power loss and sending the calculated actual power to the RF generator to generate an RF signal.

Abstract: The present invention teaches a test device for a display panel which contains a signal transmission module, a first single reception module, and a second signal reception module. The signal transmission module transmits a test signal along a first conductive line in an active area and along a second conductive line in a fan-out area of the display panel simultaneously. The first and second signal reception modules detect the test signal on the first and second conductive line, respectively, so as to determine their conductivity. The present invention also teaches a test method for a display panel. By adding the second signal reception module in the fan-out area of the display panel, the present invention is able to effectively locate a faulty conductive line in the fan-out area where repair can be conducted. The yield of the display panel is as such enhanced.

Abstract: A low-side (LS) output pre-driver has a short-circuit-to-battery fault detection scheme for a MOSFET switch having a drain connection to a load connected to a battery voltage and a source connection tied to ground. The LS output pre-driver includes a comparator, a reference voltage selector, a multi-phase blank/filter, a multi-phase control timer. The first signal of the multi-phase control timer instructs the reference voltage selector to select which of the plurality of reference voltage signals is provided to the second input of the comparator. The second signal of the multi-phase control timer instructs the multi-phase blank/filter to change from one of the plurality of time intervals to another of the plurality of time intervals.

Abstract: A method of detecting a leakage current in an electrosurgical system operating at a high frequency includes: coupling an RF generator to a pair of RF output leads via an electrical interface, the RF generator having an operating frequency; inducing a test signal at an output of the electrical interface, the test signal having a test signal frequency that is less than the operating frequency; and monitoring for a presence of an induced common mode current that would indicate the presence of leakage current.

Abstract: Example implementations described herein are directed to detection of anomalous events and locations on the transmission power system using phasor management unit (PMU) data, which provides information to grid operators for online decision support. From the high-resolution time synchronized PMU data, the transient abnormal events can be monitored and locations can be disclosed to operators for remedy actions. Utilization of PMU information for such decision support compliments operation practices relying on supervisory control and data acquisition (SCADA) measurements at much lower data resolution. Accurate identification of event locations can further advise grid operators the root cause of disturbances and illuminate possible cascading failures. Implementations of the proposed technology may improve the resilience and reliability of the transmission power systems.

Abstract: Damage preventing identification system for electrical conductors and coupling points including at least one identification unit arranged for arrangement to a surface, end cap or cable shoe of an electrical conductor, which identification unit is provided with an encapsulation for arrangement of the identification unit to the electrical conductor, and for housing means for visual and electronic tagging, which identification unit further includes means for measuring temperature and/or current.

Abstract: A method determines a fault location in a fault on an electric line. Accordingly first reference voltage values are determined by current and voltage sampled values at a first line end and an impedance of the line. Second reference voltage values are determined by current and voltage sampled values at a second line end and the impedance. Fictitious first reference voltage values are calculated using a wave guiding model, describing the wave response of the line, with the first reference voltage values. The fictitious first reference voltage values, in the fault-free case, correspond to the second reference voltage values at the second line end. Fictitious second reference voltage values are calculated with the second reference voltage values. The fault location is determined by the first and second reference voltage values and the first and second fictitious reference voltage values.

Abstract: An insulation degradation monitoring device by which a degradation state of an insulator can be constantly monitored by a simple configuration, and a degradation degree can be decided. An insulation degradation monitoring device for an insulator, by which a high-voltage charging portion of an electric instrument is insulated from and supported to a grounding metal component, includes a penetration-type electric current sensor which is inserted to a connecting portion of the insulator and the grounding metal component, and detects a leakage electric current which is passed from the high-voltage charging portion through the insulator and is flowed to the grounding metal component; and a decision means which is connected to an output side of the electric current sensor, and decides a degradation degree of the insulator in accordance with a value of the leakage electric current.

Abstract: An arc detection apparatus (10) includes an arc detection circuit (102), a current transforming unit (128), a current input wire (108) and a current output wire (110). A power supply apparatus (20) sends an input current (Iin_a) to an electronic apparatus (30) through the current input wire (108), and the electronic apparatus (30) sends back an output current (Iin_b) to the power supply apparatus (20) through the current output wire (110), so that the current transforming unit (128) induces and generates an induced current (112). The current transforming unit (128) sends the induced current (112) to the arc detection circuit (102). The arc detection circuit (102) utilizes the induced current (112) to detect an arc.