Patents Issued in July 4, 2017
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Patent number: 9695453Abstract: A method of producing hyaluronic acid (HA) in Escherichia coli and Bacillus megaterium through episomal plasmid vectors wherein the gene is under the control of strong promoter T7, preferably under the control of strong promoter T7 of bacteriophage T7, and a system for the selection of stable bacterial strains producing high levels of hyaluronic acid, are provided.Type: GrantFiled: October 15, 2015Date of Patent: July 4, 2017Assignee: FIDIA FARMACEUTICI S.P.A.Inventors: Vincenza Corsa, Alessandro Negro, Sonia Bisicchia
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Patent number: 9695454Abstract: Described herein are compositions including filamentous fungal cells, such as Trichoderma fungal cells, having reduced protease activity and expressing fucosylation pathway. Further described herein are methods for producing a glycoprotein having fucosylated N-glycan, using genetically modified filamentous fungal cells, for example, Trichoderma fungal cells, as the expression system.Type: GrantFiled: May 23, 2013Date of Patent: July 4, 2017Assignee: GLYKOS FINLAND OYInventors: Jari Natunen, Ann Westerholm-Parvinen, Hanna Salo, Jussi Joensuu, Heli Viskari, Christopher Landowski, Anne Huuskonen, Anne Kanerva, Anna-Liisa Hanninen, Noora Salovuori, Merja Penttila, Juhani Saarinen, Markku Saloheimo
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Patent number: 9695455Abstract: A method of producing protein nanoparticles from waste chicken feathers by enzymatic hydrolysis followed by ultrasonic treatment is disclosed. The process includes pretreatment of the chicken feathers. Then feather fibers are hydrolyzed enzymatically. The effects of enzyme concentration, hydrolysis time, and substrate concentration on particle mean size are analyzed to optimize the best condition in order to attain the smallest particles by a Box-Behnken Design. A minimum particle size is obtained by using 5 g/l feather and 3.6% enzyme with a hydrolysis time of 243 h. The hydrolyzed particles are then subjected to ultrasonic treatment to produce nanoparticles. The produced protein particles have high potential to be used in nanocomposites and adsorbents.Type: GrantFiled: March 9, 2015Date of Patent: July 4, 2017Inventors: Niloofar Eslahi, Fatemeh Dadashian, Nahid Hemmatinejad
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Patent number: 9695456Abstract: A solution is the microorganism testing apparatus equipped with a pre-processing unit in which, if a content of microorganism testing on a specific specimen is selected or input, testing conditions of the specimen read from a storage device in which testing information specifying the testing conditions of the specimen is stored are printed on a sheet-form medium to be used for testing of the specimen, and a post-processing unit in which, if an image of the medium is read, the testing conditions printed on the medium and a type of the medium preliminarily labelled on the medium are acquired from the image to output judgment results as to whether or not the testing conditions acquired from the image, and the type of the medium are compatible.Type: GrantFiled: November 12, 2015Date of Patent: July 4, 2017Assignee: JNC CORPORATIONInventors: Hajime Teramura, Hiromi Osawa, Ryuzo Kimura, Ikuo Sato
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Patent number: 9695457Abstract: Methods for the detection or diagnosis of a bacterial infection or colonization utilizing mass spectrometric analysis are provided. The methods involve short-term enrichment of samples followed by mass spectrometric analysis of biomarker profiles. Also provided are methods for preparing short-term enrichment cultures.Type: GrantFiled: February 5, 2010Date of Patent: July 4, 2017Assignee: OM Research LimitedInventor: Pranav Somaiya
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Patent number: 9695458Abstract: Provided is a sample dish for detecting microbes. The sample dish includes a base having an opening extending therethrough, an outer side wall at the outer periphery of the base, and an inner side wall at the inner periphery of the base defined by the opening. The sample dish may be used in conjunction with a microbial test unit including a housing defining an internal cavity configured to contain a sample dish, the unit including a cuff extending from an outlet of the housing into the internal cavity. The cuff may be an open-ended member configured to extend through an opening of the sample dish and provide fluid communication between the internal cavity and the outlet. The microbial test unit provides the ability to test compressed gas directly input to the unit.Type: GrantFiled: August 19, 2014Date of Patent: July 4, 2017Assignee: Parker-Hannifin CorporationInventors: John D'Antonio, H. Lee Scott
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Patent number: 9695459Abstract: The present invention provides a method for determining whether or not a test sample contains a phytopathogenic oomycete selectively from two kinds of oomycetes of a phytopathogenic oomycete and a non-phytopathogenic oomycete. The method according to the present invention comprises: (a) putting the test sample on a front surface of a cellulose film; wherein the cellulose film has a thickness of not less than 0.5 micrometers and not more than 3.7 micrometers; (b) leaving the test sample at rest for not less than 4 hours and not more than 8 hours after the step (a); (c) observing a back surface of the film after the step (b); and (d) determining that the test sample contains the phytopathogenic oomycete, if an oomycete is found on the back surface of the film in the step (c).Type: GrantFiled: November 21, 2015Date of Patent: July 4, 2017Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.Inventor: Yoshitsugu Uriu
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Patent number: 9695460Abstract: Disclosed is a method for quantifying L-tryptophan involving a step for mixing a specimen, L-tryptophan oxidase, and water, a step for allowing the obtained reaction solution to stand a predetermined period of time in the presence of oxygen, and a step for measuring the reaction product resulting from action of enzymes present in the reaction solution after allowing to stand. Also disclosed are a kit used to quantify the L-tryptophan containing L-tryptophan oxidase, and an enzyme sensor using the L-tryptophan oxidase. This method, kit and enzyme sensor use an L-tryptophan-specific enzyme, so are capable of quantifying L-tryptophan even in the presence of other amino acids.Type: GrantFiled: September 3, 2013Date of Patent: July 4, 2017Assignees: Public University Corporation Toyama Prefectural University, Ajinomoto Co., Inc.Inventors: Yasuhisa Asano, Masafumi Kameya, Hiroyasu Onaka
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Patent number: 9695461Abstract: The stabilization of a hydrolytic enzyme in a liquid preparation is to be improved through a component that stabilizes the hydrolytic enzyme. This is accomplished by a method for adapting a hydrolytic enzyme to a component that stabilizes the hydrolytic enzyme, comprising the following method steps: a) providing a hydrolytic enzyme (starting enzyme) and a component that stabilizes the hydrolytic enzyme and that comprises a reversible inhibitor of the hydrolytic enzyme; b) changing the amino acid sequence of the hydrolytic enzyme in at least one position, by substitution, deletion or insertion; c) determining the relative activity of the hydrolytic enzyme from step b) and the relative activity of the starting enzyme in a liquid preparation; d) selecting the hydrolytic enzyme that has a reduced relative activity by comparison with the relative activity of the starting enzyme.Type: GrantFiled: March 6, 2014Date of Patent: July 4, 2017Assignee: Henkel AG & Co. KGaAInventors: Petra Siegert, Stefan Evers, Marion Merkel, Nina Mussmann, Hendrik Hellmuth, Timothy O'Connell, Karl-Heinz Maurer, Ulrich Schwaneberg, Felix Jakob, Ronny Martinez, Brian Laufs, Ayhan Aydemir, Thomas Weber
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Patent number: 9695462Abstract: The present invention is related to a method for evaluation of drug efficacy of a medicine having a therapeutic or preventive effect against a disease related to EL activity wherein phosphatidylinositol or lysophosphatidylinositol is used as an indicator. The present invention is also related to a method for screening an inhibitor of EL activity using phosphatidylinositol and a kit for use in the method.Type: GrantFiled: November 5, 2013Date of Patent: July 4, 2017Assignee: SHIONOGI & CO., LTD.Inventors: Takashi Ono, Atsuko Yamamoto, Shuhei Shigaki
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Patent number: 9695463Abstract: Methods for identifying a test agent as a modulator of the active DNA demethylation activity of a DNA methyltransferase are disclosed. The method comprises: a) providing a methylated DNA; b) providing the DNA methyltransferase; c) allowing the methylated DNA to react with the DNA methyltransferase for a sufficient time to perform a demethylation reaction and generate a demethylated DNA product in the presence or absence of a test agent; d) analyzing the extent of demethylation; and d) comparing the extents of the demethylation in the presence and absence of the test agent, and thereby identify the test agent as a modulator of the DNA demethylation activity of the DNA methyltransferase.Type: GrantFiled: December 10, 2013Date of Patent: July 4, 2017Assignee: ACADEMIA SINICAInventors: Che-Kun James Shen, Chun-Chang Chen
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Patent number: 9695464Abstract: The invention provides an enzymatic method for measuring the concentration of one or more analytes in the plasma portion of a blood derived sample, containing a first and a second component, where said second component interferes with the measurement of said first component.Type: GrantFiled: November 9, 2012Date of Patent: July 4, 2017Assignee: AXIS-SHIELD ASInventors: Arne Ludvig Faaren, Frank Frantzen, Arne Kristian Nordhei, Erling Sundrehagen, Lars Ørning
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Patent number: 9695465Abstract: The present invention pertains to a method for isolating nucleic acids from a sample, preferably a blood sample, comprising the following steps: a) obtaining a sample which has been stabilized by the use of at least one cationic detergent, wherein the cationic detergent has formed complexes with the nucleic acids; b) obtaining the complexes optionally together with other sample components from the stabilized sample, wherein said complexes comprise the nucleic acids to be isolated; c) resuspending the complexes and optionally adding one or more additives before, during and/or after resuspension, thereby obtaining a resuspended sample comprising at least: i) the nucleic acid to be isolated; ii) at least one chaotropic agent; and iii) at least one chelating agent; and d) isolating nucleic acids from the resuspended sample.Type: GrantFiled: August 13, 2012Date of Patent: July 4, 2017Assignee: QIAGEN GMBHInventor: Thorsten Voss
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Patent number: 9695466Abstract: The invention relates to methods to reduce the length of a homonucleotide repeat sequence a target DNA sequence. This is done by using an oligonucleotide primer which extends in the unaltered repeat of identical nucleotides of the target polynucleotide, the oligonucleotide primer comprises at the at the 5? side a sequence which hybridizes with the sequence preceding the targeted sequence repeat, but the oligonucleotide primer is not 100% complementary with the sequence repeat in the target sequence.Type: GrantFiled: May 9, 2014Date of Patent: July 4, 2017Assignee: DNAME-ITInventor: Harry Cuppens
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Patent number: 9695467Abstract: A system and method for the processing of nucleic acids containing fluids involving manipulation of magnetically responsive particles contained therein are disclosed. In the system, a holder holds a plurality of containers containing the fluids, a heating device applies thermal energy to the fluids for incubation, and a separating device magnetically separates the particles. The heating and separating devices move into at least one operative position for processing the fluids and at least one inoperative position with respect to the containers, in which the containers are kept stationary at least during and in-between incubating the fluids and manipulating the magnetically responsive particles.Type: GrantFiled: November 25, 2014Date of Patent: July 4, 2017Assignee: Roche Molecular Systems, Inc.Inventors: Reto Keller, Thomas Meyer
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Patent number: 9695468Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.Type: GrantFiled: February 17, 2015Date of Patent: July 4, 2017Assignee: 10X GENOMICS, INC.Inventors: Benjamin Hindson, Serge Saxonov, Michael Schnall-Levin
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Patent number: 9695469Abstract: The invention relates to a method for analyzing a genomic region of an organism, comprising four major parts. The first part involves the isolation of mRNA from a selected organism that is used for the preparation of small single stranded DNA fragments with one adaptor containing an affinity label. These DNA fragments are used in part three. In the second part, genomic DNA from the same or a related organism is isolated. This genomic DNA is fragmented and ligated to adaptor molecules. In the third part, these genomic fragments are hybridized with single stranded DNA fragments from part one, and the hybrids formed in this process are used for synthesis of DNA fragments. These fragments will be used in part four which involves sequencing of these fragments using one of the available high throughput sequencing methods.Type: GrantFiled: March 17, 2009Date of Patent: July 4, 2017Assignee: STICHTING GENETWISTER IPInventors: Anne Douwe De Boer, Michaël Johannes Marcus Ebskamp, Simon Albertus Langeveld, Ivo Laros, Miranda Debora Van De Rhee
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Patent number: 9695470Abstract: The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template. Because the nucleotide analogs have an unmodified 3? OH, i.e., as found in “natural” deoxyribose and ribose molecules, the analogs result in natural polynucleotides suitable for incorporation into biological systems.Type: GrantFiled: February 19, 2016Date of Patent: July 4, 2017Assignee: Molecular Assemblies, Inc.Inventors: J. William Efcavitch, Suhaib Siddiqi
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Patent number: 9695471Abstract: Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule.Type: GrantFiled: December 29, 2014Date of Patent: July 4, 2017Assignee: Life Technologies CorporationInventors: Joseph Beechem, Theo Nikiforov, Vi-En Choong, Xinzhan Peng, Guobin Luo, Cheng-Yao Chen, Michael Previte
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Patent number: 9695472Abstract: Embodiments of the present invention provide devices methods for sequencing DNA using arrays of reaction regions containing electronic sensors to monitor changes in solutions contained in the reaction regions. Test and fill reaction schemes are disclosed that allow DNA to be sequenced. By sequencing DNA using parallel reactions contained in large arrays, DNA can be rapidly sequenced.Type: GrantFiled: November 19, 2010Date of Patent: July 4, 2017Assignee: INTEL CORPORATIONInventors: Xing Su, Kai Wu
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Patent number: 9695473Abstract: The present invention relates to a genotyping method, and more particularly to an ID sequence, which is assigned to each genotype, and a multiplex genotyping method which uses the ID sequence. When pyrosequencing is performed using the ID sequence, a unique and simple pyrogram can be obtained for each genotype. Thus, the use of the ID sequence makes it possible to genotype viral genes, disease genes, bacterial genes and identification genes in a simple and efficient manner. In addition, a genotyping primer of the invention can be used in various genotyping methods which are performed using dispensation orders and sequencing methods.Type: GrantFiled: July 28, 2015Date of Patent: July 4, 2017Assignee: GENOMICTREE, INC.Inventors: Sung Whan An, Myung Sok Oh
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Patent number: 9695474Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.Type: GrantFiled: May 19, 2016Date of Patent: July 4, 2017Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Everett Hurteau Meyer
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Patent number: 9695475Abstract: The present invention provides compounds and methods for competitive modulation of microRNAs. Such compounds and methods have profound effects on cells. MicroRNAs (microRNAs), are small (approximately 18-24 nucleotides in length), non-coding RNA molecules encoded in the genomes of plants and animals. In certain instances, microRNAs regulate the expression of genes by binding to the 3?-untranslated regions (3?-UTR) of specific mRNAs. More than 1000 different microRNAs have been identified in plants and animals.Type: GrantFiled: December 11, 2013Date of Patent: July 4, 2017Assignee: Ionis Pharmaceuticals, Inc.Inventors: Xue-hai Liang, Stanley T. Crooke
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Patent number: 9695476Abstract: The invention provides an in vitro method or assay for the diagnosis of osteochondrosis or prediction of the likelihood of its onset in a terrestrian mammal, comprising measuring the expression level of a marker in a sample obtained from said terrestrian mammal and comparing said expression level to the expression level of said marker measured in a sample obtained from one or more terrestrian mammals of the same species not affected by osteochondrosis, wherein the marker is ApoB-3G, and wherein an increase in the expression level of ApoB-3G is indicative of osteochondrosis. The invention also provides a diagnostic kit for use in said method, which comprises at least one agent, which binds specifically to the product of the gene of the respective marker and which can be used to determine the expression level of said marker, wherein the marker is ApoB-3G.Type: GrantFiled: October 9, 2013Date of Patent: July 4, 2017Assignees: UNIVERSITE DE LIEGE, SKULDTECH S.A.Inventors: Didier Serteyn, Charlotte Sandersen, Jean-Philippe Lejeune, David Piquemal
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Patent number: 9695477Abstract: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals.Type: GrantFiled: October 13, 2016Date of Patent: July 4, 2017Assignee: Natera, Inc.Inventors: Matthew Rabinowitz, Milena Banjevic, Zachary Demko, David Johnson
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Patent number: 9695478Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.Type: GrantFiled: May 13, 2010Date of Patent: July 4, 2017Assignee: EPIGENOMICS AGInventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
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Patent number: 9695479Abstract: Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations, markedly fewer than in common adult cancers. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone H3K4 trimethylase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.Type: GrantFiled: November 8, 2011Date of Patent: July 4, 2017Assignees: The Johns Hopkins University, Duke UniversityInventors: Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Donald Williams Parsons, Rebecca J. Leary, Meng Li, Xiaosong Zhang, Sian Jones, Gregory J. Riggins, Victor Velculescu, Darell Bigner, Hai Yan
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Patent number: 9695480Abstract: The present application relates to an ex vivo or in vitro method to determine the presence or absence of a mutation or a variation in the NF-E2 gene in a sample from a patient suffering from a myeloid neoplasm or solid tumor whereby said method comprises: a) obtaining a nucleic acid sample from the patient, b) detecting the presence or absence of a mutation in the nucleic acid sample comprising the NF-E2 gene or a fragment thereof, characterized in that the presence of the mutation is an indication of a myeloid neoplasm or solid tumor, whereby the mutation is determined by comparing the nucleic acid sequence obtained from the sample with SEQ ID NO:1 or the complement thereof.Type: GrantFiled: February 7, 2013Date of Patent: July 4, 2017Assignee: Universitaetsklinikum FreiburgInventors: Heike Pahl, Jonas Jutzi
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Patent number: 9695481Abstract: The invention provides a polynucleotide comprising a reporter sequence operatively linked to a regulatory element of a gene selected from Bscl2, Srxnl, Cbr3, Ephxl, Nope, Cdknla, Perp, Pltp, Cgrefl, Ltb4r1, Btg2, Gpx2, Ltb4r2, Ddit4l, Fosl1, and Egr1, which regulatory element stimulates expression of the reporter sequence in response to a genotoxic agent or to an oxidative stress-inducing agent. The invention also provides a method of detecting a genotoxic or oxidative stress-inducing agent comprising subjecting a cell containing the polynucleotide of the invention to a test agent; and assessing the expression of the reporter sequence.Type: GrantFiled: September 15, 2011Date of Patent: July 4, 2017Assignees: UNIVERSITEIT LEIDEN, ACADEMISCH ZIEKENHUIS LEIDENInventors: Bob Van de Water, Harm Vrieling
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Patent number: 9695482Abstract: In a method and system for forming concentrated volumes of microbeads, a polymer solution and/or suspension includes a polymer dissolved and/or dispersed in a medium. Streams of a focusing fluid and of the polymer solution and/or suspension flow towards a fluid bath, and into intersection with one another, so as to focus the polymer solution and/or suspension. The polymer solution and/or suspension stream forms microbeads in the fluid bath Some of the focusing fluid is drawn from the fluid bath, so as to concentrate the microbeads in the fluid bath. The system includes a flow focusing apparatus and a liquid-containing cell. The focusing apparatus includes polymer and focusing nozzles. The cell contains the fluid bath and has an outlet port, through which the focusing fluid is drawn.Type: GrantFiled: October 7, 2013Date of Patent: July 4, 2017Assignee: Fio CoporationInventors: Sebastian Fournier-Bidoz, Warren Che Wor Chan
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Patent number: 9695483Abstract: Disclosed are a method of determining an HPV integration site in a genome of a human tissue sample and a system thereof. The method comprises: subjecting genome DNA of the human tissue sample to a first sequencing, to obtain a sequencing result; determining DNA fragments containing both HPV sequence and human genome sequence, based on the sequencing result; determining a pair of amplification primers based on the DNA fragments containing both HPV sequence and human genome sequence, subjecting the genome DNA of the human tissue sample to PCR amplification using the pair of amplification primers, to obtain PCR product; and subjecting the PCR product to a second sequencing, to determine the integration site in a genome of the human tissue sample. The method is easy to be operated with low cost, high efficiency and excellent repeatability, which may be used to detect all HPV genotypes one time, and may rapidly and accurately determine detailed sequence information and integration site.Type: GrantFiled: July 15, 2014Date of Patent: July 4, 2017Assignee: BGI Biotechnology (Wuhan) Co., Ltd.Inventors: Yong Zhang, Zhixiang Yan, Lijin You, Lichao Cao, Ping Xiao
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Patent number: 9695484Abstract: In an embodiment of the present disclosure, a sugar product and method for fabricating the same is provided. The method includes mixing an acid compound and lithium chloride, magnesium chloride, calcium chloride, zinc chloride or iron chloride or lithium bromide, magnesium bromide, calcium bromide, zinc bromide or iron bromide or heteropoly acid to form a mixing solution, adding a cellulosic biomass to the mixing solution for a dissolution reaction, and adding water to the mixing solution for a hydrolysis reaction to obtain a sugar product. The present disclosure also provides a sugar product fabricated from the method.Type: GrantFiled: September 27, 2013Date of Patent: July 4, 2017Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Ruey-Fu Shih, Jia-Yuan Chen, Hui-Tsung Lin, Hom-Ti Lee, Hou-Peng Wan, Wei-Chun Hung
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Patent number: 9695485Abstract: The invention relates to a method for processing steel slag to produce a hydraulic mineral binder with a high hardening potential and to recover iron. There is provision for this purpose to provide a feed product comprising steel slag with MnO. This feed product is further processed as a melt by introducing reducing agent into the melt. A lime saturation factor of between 90 and 110 is hereby to be achieved in the mineral melt portion. Subsequently the melt is cooled in a defined manner and elementary iron is mechanically separated from the solidified melt. The solidified melt is then supplied for use as hydraulic mineral binder. Furthermore the invention relates to a hydraulic mineral binder.Type: GrantFiled: September 6, 2012Date of Patent: July 4, 2017Assignee: LOESCHE GmbHInventors: Holger Wulfert, Horst-Michael Ludwig
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Patent number: 9695486Abstract: There is provided a Cr-containing austenitic alloy having a chromium oxide film with a thickness of 5 nm or larger on the surface, wherein the content of Mn in a base metal is, by mass percent, less than 0.1%. The chemical composition of the base metal desirably consists of, by mass percent, C: 0.15% or less, Si: 1.00% or less, Mn: less than 0.1%, P: 0.030% or less, S: 0.030% or less, Cr: 10.0 to 40.0%, Ni: 8.0 to 80.0%, Ti: 0.5% or less, Cu: 0.6% or less, Al: 0.5% or less, and N: 0.20% or less, the balance being Fe and impurities.Type: GrantFiled: February 27, 2013Date of Patent: July 4, 2017Assignee: NIPPON STEEL & SUMITOMO METAL CORPORATIONInventors: Yasuhiro Masaki, Manabu Kanzaki, Yasuyoshi Hidaka, Akihiro Uehira, Osamu Miyahara
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Patent number: 9695487Abstract: The present invention provides a high-strength wear-resistant steel plate with Brinell hardness of ?HB420, comprising the following chemical compositions (by weight %) C: 0.205-0.25%, Si: 0.20-1.00%, Mn: 1.0-1.5%, P?0.015%, S?0.010%, Al: 0.02-0.04%, Ti: 0.01-0.03%, N?0.006%, Ca?0.005%, and at least one of Cr?0.70%, Ni?0.50%, Mo?0.30%, other compositions being Ferrum and unavoidable impurities. Also provided is a method of manufacturing the wear-resistant steel plate has remarkable TRIP effect in use, improving substantially its wear resistance, thereby meeting the high demand for wear-resistant steel plates in related industries.Type: GrantFiled: May 25, 2012Date of Patent: July 4, 2017Assignee: Baoshan Iron & Steel Co., Ltd.Inventors: Aiwen Zhang, Guodong Wang, Sihai Jiao
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Patent number: 9695488Abstract: A steel is used for providing a bolt that has a high strength and still exhibits excellent hydrogen embrittlement resistance. The steel contains C of 0.30% to 0.50%, Si of 1.0% to 2.5%, Mn of 0.1% to 1.5%, P of greater than 0% to 0.015%, S of greater than 0% to 0.015%, Cr of 0.15% to 2.4%, Al of 0.010% to 0.10%, N of 0.001% to 0.10%, Cu of 0.1% to 0.50%, Ni of 0.1% to 1.0%, Ti of 0.05% to 0.2%, and V of 0% to 0.2%, with the remainder including iron and inevitable impurities, in which a ratio [Ni]/[Cu] is 0.5 or more, and a total content [Ti]+[V] is 0.085% to 0.30%.Type: GrantFiled: November 26, 2012Date of Patent: July 4, 2017Assignee: Kobe Steel, Ltd.Inventors: Yosuke Matsumoto, Atsushi Inada, Masamichi Chiba
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Patent number: 9695489Abstract: A method of forming a gun barrel is disclosed that includes applying one or more coatings to the gun barrel such as just a top coating, or a bond coating and then a top coating. The method may also include (before applying one or more coatings): threading an outer surface of the gun barrel proximate a first end of the gun barrel; threadedly coupling the first end of the gun barrel to a gun chamber; fixedly coupling the gun barrel to the gun chamber. The method may also include heat treating the coating layer(s), contouring the outer coating layer, applying a ceramic top coating to the contoured outer coating layer of the gun barrel, and/or sealing the gun barrel with a liquid metal sealer.Type: GrantFiled: June 14, 2016Date of Patent: July 4, 2017Assignee: Gunwright Intellectual Property LLCInventor: David W. Wright
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Patent number: 9695490Abstract: Hydrometallurgical systems, methods, and compositions are described in which organic amine-based lixiviants are utilized in the selective recovery of alkaline earth elements. The lixiviant can be regenerated and recycled for use in subsequent iterations of the process. Multiple alkaline earth elements can be recovered from a sample in parallel or in serial applications of the disclosed methods.Type: GrantFiled: November 6, 2013Date of Patent: July 4, 2017Assignee: LIXIVIA, INC.Inventors: Zachary J. A. Komon, Michael D. Wyrsta
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Patent number: 9695491Abstract: The disclosure relates to a beneficiation process for low grade uranium ore, wherein the process comprises a primary beneficiation stage comprising: wet scrubbing the low grade uranium ore to separate the low grade ore into a fine fraction and a coarse fraction; screening the fine fraction according to a size separation parameter to provide an undersize fraction and an oversize fraction, wherein the uranium predominantly reports to the undersize fraction; and separating the undersize fraction to produce an intermediate uranium concentrate. The intermediate uranium concentrate may be further processed in a secondary beneficiation stage to produce a high grade uranium concentrate.Type: GrantFiled: April 23, 2013Date of Patent: July 4, 2017Assignee: Uranium Beneficiation Pty LtdInventor: Murray Philip Hill
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Patent number: 9695492Abstract: A method for producing a high purity high carbon molten chrome product from chrome and carbon bearing material, said method comprising the steps of: (a) continuously introducing chrome compacts directly into an electric melter; (b) heating and melting the chrome compacts in the electric melter at a temperature of between about 1300° C. to about 1700° C. to form high carbon molten chrome; (c) preventing oxidation of the high carbon molten chrome via minimization of the ingress of oxygen containing gas in said heating step; (d) carburizing the high carbon molten chrome to form high carbon molten metallized chrome; (e) purifying the high carbon molten metallized chrome by reducing silicon oxides to silicon and desulfurizing the high carbon molten metallized chrome to produce the high purity high carbon molten chrome product; and (f) discharging the high purity high carbon molten chrome product from the electric melter.Type: GrantFiled: May 30, 2014Date of Patent: July 4, 2017Assignee: Midrex Technologies, Inc.Inventor: Vincent Chevrier
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Patent number: 9695493Abstract: A dual phase or complex phase steel strip showing no tigerstripes. The steel strip having an ultimate tensile strength Rm classifying for 1000 MPa steel category, includes (in mass percent) C 0.09-0.19%; Mn 1.9-2.6%; Si at most 0.1%; Cr 0.4-0.8%; Mo at most 0.3%; Ni at most 0.4%; Al 0.02-1.3%; and optionally one or more of the following elements: Nb at most 0.08%; P equal to or more than 0.0005%; N equal to or less than 0.015%; Ti equal to or less than 0.1%; V equal to or less than 0.1%; B equal to or less than 0.01%; wherein the sum of Cr, Mo and Ni is at least 0.5%; the balance being Fe and inevitable impurities.Type: GrantFiled: April 5, 2013Date of Patent: July 4, 2017Assignee: TATA STEEL IJMUIDEN BVInventors: Egbert Jansen, Edward Anton Frederik Span, Richard Mostert, Theo Arnold Kop
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Patent number: 9695494Abstract: Compositions for forming Au-based bulk-solidifying amorphous alloys are provided. The Au-based bulk-solidifying amorphous alloys of the current invention are based on ternary Au—Cu—Si alloys, and the extension of this ternary system to higher order alloys by the addition of one or more alloying elements. Additional substitute elements are also provided, which allow for the tailoring of the physical properties of the Au-base bulk-solidifying amorphous alloys of the current invention.Type: GrantFiled: July 18, 2013Date of Patent: July 4, 2017Assignee: Crucible Intellectual Property, LLCInventors: Jan Schroers, Atakan Peker
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Patent number: 9695495Abstract: An aluminum alloy sheet for motor vehicles is produced by casting a melt, containing 3.0-3.5 mass % Mg, 0.05-0.3 mass % Fe, 0.05-0.15 mass % Si, and less than 0.1 mass % Mn, a balance substantially being inevitable impurities and Al, into a slab having a thickness of 5 to 15 mm in a twin-belt caster so that cooling rate at ¼ depth of thickness of the slab is 20 to 200° C./sec; winding the cast thin slab into a coiled thin slab subjected to cold rolling with a roll having a surface roughness of 0.2 to 0.7 ?m Ra at a cold rolling reduction of 50 to 98%; subjecting the cold rolled sheet to final annealing either continuously in a CAL at a holding temperature of 400 to 520° C. within 5 minutes or in a batch annealing furnace at a holding temperature of 300 to 400° C. for 1 to 8 hours; and subjecting the resulting sheet to straightening with a leveler.Type: GrantFiled: December 29, 2014Date of Patent: July 4, 2017Assignee: NIPPON LIGHT METAL CO., LTD.Inventors: Pizhi Zhao, Toshiya Anami, Kazumitsu Mizushima, Akira Goto, Hitoshi Kazama, Kunihiro Yasunaga
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Patent number: 9695496Abstract: The invention relates to a method and to an apparatus for avoiding surface defects, which are caused by zinc dust, on galvanized metal strip in continuous strip galvanization, in which metal strip which is to be galvanized and is heated in a continuous annealing furnace is moved through a furnace pipe in protective furnace gas and is immersed into a zinc bath, wherein the furnace pipe is provided with injection openings via which the front side and the rear side of the metal strip can be acted upon with protective furnace gas, and wherein extraction openings for extracting protective furnace gas loaded with zinc vapor are arranged adjacent to the injection openings.Type: GrantFiled: July 5, 2013Date of Patent: July 4, 2017Assignee: THYSSENKRUPP STEEL EUROPE AGInventors: Norbert Schaffrath, Sabine Zeizinger, Michael Peters, Gernot Nothacker, Klaus Josef Peters
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Patent number: 9695497Abstract: In a method for a finishing work of a spray-coated surface, an inner surface of a cylindrical hollow member is roughened by forming a helical groove thereon. A thermal spray coating is formed on the inner surface that is roughened, and a finishing work is carried out by cutting the thermal spray coating along a helix of the groove by use of a cutting tool. According to the method for a finishing work, a finishing work of a thermal spray coating with non-uniform hardness can be carried out efficiently.Type: GrantFiled: February 28, 2013Date of Patent: July 4, 2017Assignee: Nissan Motor Co., Ltd.Inventors: Takafumi Watanabe, Masatoshi Inoguchi, Kiyokazu Sugiyama, Daisuke Terada, Yoshitsugu Noshi
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Patent number: 9695498Abstract: This invention relates to a partially carbonitriding heat treated stainless steel ferrule, having a first region with a first hardness and a second region with a second hardness, wherein the first region includes a nitrogen layer having a nitrogen concentration higher than a carbon concentration, and a carbon layer formed under the nitrogen layer and having a carbon concentration higher than a nitrogen concentration, so that the first hardness is greater than the second hardness. Thereby, partial heat treatment is effective at preventing rotational torque of the region, except for the portion to be heat treated, from increasing due to the total hardening.Type: GrantFiled: October 17, 2014Date of Patent: July 4, 2017Assignee: DK-LOK CORPORATIONInventors: Eun Sik Noh, Sam Rae Jung
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Patent number: 9695499Abstract: Provided is a nanowire manufacturing substrate, comprising a grid base layer on a substrate and a grid pattern formed by patterning the grid base layer, the grid pattern being disposed to produce a nanowire on a surface thereof. According to the present invention, the width and height of the nanowire can be adjusted by controlling the wet-etching process time period, and the nanowire can be manufactured at a room temperature at low cost, the nanowire can be mass-manufactured and the nanowire with regularity can be manufactured even in case of mass production.Type: GrantFiled: July 28, 2014Date of Patent: July 4, 2017Assignee: LG INNOTEK CO., LTD.Inventors: Young Jae Lee, Kyoung Jong Yoo, Jun Lee, Jin Su Kim, Jae Wan Park
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Patent number: 9695500Abstract: A mask frame assembly including a frame including a first opening, a first mask including second openings that each has an area smaller than the first opening and a first surface having portions of the first surface connected to the frame. The mask frame assembly includes second masks disposed on a second surface of the first mask extending across the first opening in a first direction and arranged in a second direction that is substantially perpendicular. The second masks include pattern parts having a shape corresponding to the second openings. The pattern parts each include pattern holes configured to allow a deposition material to pass through. The second masks include a rib part disposed between the pattern parts. The rib part includes dummy holes each having an area greater than each of the pattern holes. The first mask is configured to block the deposition material passing through the dummy holes.Type: GrantFiled: December 18, 2015Date of Patent: July 4, 2017Assignee: Samsung Display Co., Ltd.Inventors: Junhyeuk Ko, Sangshin Lee
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Patent number: 9695501Abstract: A method to deposit a layer of harder thin film substrate onto a softer substrate. In particular, the present invention provides a method to deposit a layer of sapphire thin film on to a softer substrate e.g. quartz, fused silica, silicon and (toughen) glass. This combination is better than pure sapphire substrate.Type: GrantFiled: March 9, 2015Date of Patent: July 4, 2017Assignee: HONG KONG BAPTIST UNIVERSITYInventors: Kok Wai Cheah, King Fai Li, Hoi Lam Tam, Wing Yui Lam, Ka Suen Lee
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Patent number: 9695502Abstract: Apparatus for processing substrates are provided herein. In some embodiments, an apparatus includes a process kit comprising a shield having one or more sidewalls configured to surround a first volume, the first volume disposed within an inner volume of a process chamber; and a first ring moveable between a first position, wherein the first ring rests on the shield, and a second position, wherein a gap is formed between an outer surface of the first ring and an inner surface of the one or more sidewalls, wherein a width of the gap is less than about two plasma sheath widths for a plasma formed at a frequency of about 40 MHz or higher and at a pressure of about 140 mTorr or lower.Type: GrantFiled: March 30, 2012Date of Patent: July 4, 2017Assignee: APPLIED MATERIALS, INC.Inventors: Alan Ritchie, Donny Young