Patents Issued in July 27, 2017
  • Publication number: 20170211030
    Abstract: A cell culture article comprises virgin polystyrene disposed over at least a portion of a surface of an article main body. The article main body may be formed from polyethylene terephthalate (PET) such as reground or recycled polyethylene terephthalate. Methods of making such a cell culture article include applying a composition to a surface of an article main body, where the composition comprises virgin polystyrene having a thickness of 1 to 500 microns and the article main body is formed from glass, ceramic, metal or polymer.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 27, 2017
    Inventors: Michael Edward DeRosa, Stephen Benedict Rimsa, Kerry Elizabeth Robinson-Thompson, Kevin Andrew Vasilakos
  • Publication number: 20170211031
    Abstract: A vessel having a mixer that ensures a homogeneous cell distribution in dispensed quantities. The vessel has a mixer therein for stirring contents of the vessel and an orifice in a lower wall to which a cell dispenser is attached. The cell dispenser dispenses quantities of suspended cells having a homogeneous cell distribution.
    Type: Application
    Filed: January 23, 2017
    Publication date: July 27, 2017
    Inventors: Chanyong Brian Lee, Yasunori Hashimura, Oscar Garza, Gary Evans
  • Publication number: 20170211032
    Abstract: A temperature regulating container handles multiple samples which can be optically measured in real time while regulating the temperature of the samples. The samples can be moved at high speed by, for example, shaking without requiring a complicated mechanism. A cell culture container is a combination of three kinds of members: a temperature regulating liquid-holding member, a sample-holding member, and a lid. The cell culture container ensures that multiple samples are contacted with a temperature regulating liquid so that the temperature of the samples can be maintained at a uniform temperature, or quickly increased. The lid contacts the surface of the samples, preventing the samples from drying and contamination and, preventing dew formation on an optical path for performing optical measurement. The distance the light passes through the samples can be held constant to thereby assure accurate optical measurement; and sample containers can be easily moved.
    Type: Application
    Filed: June 17, 2015
    Publication date: July 27, 2017
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Akira MASUYA, Muneo MAESHIMA, Yasunori SHOJI
  • Publication number: 20170211033
    Abstract: Various embodiments of the present invention pertain to methods for biological production of hydrogen. More specifically, embodiments of the present invention pertain to a modular energy system and related methods for producing hydrogen using organic waste as a feed stock.
    Type: Application
    Filed: November 21, 2016
    Publication date: July 27, 2017
    Applicant: Purdue Research Foundation
    Inventors: Robert Kramer, Libbie S. Pelter, John A. Patterson
  • Publication number: 20170211034
    Abstract: Spent stillage remaining after the fermentation of a feedstock for ethanol production may be processed to recover, use, and/or recycle the constituent components of the stillage. Stillage may be mixed, heated, and held at a desired temperature for a period of time. The stillage may then be cooled and treated with an enzyme. The enzymatically treated stillage may be emulsified with oil and water, and then permitted to settle into discrete layers. Individual layers may then be processed.
    Type: Application
    Filed: January 27, 2017
    Publication date: July 27, 2017
    Applicant: Lucas E3, L.C.
    Inventor: Scott Lucas
  • Publication number: 20170211035
    Abstract: This invention relates to a biological indicator, comprising: a carrier inoculated with a test organism and an effective amount of a carbohydrate to reduce the resistance of the biological indicator to steam sterilization. The invention relates to a steam sterilization process using the biological indicator.
    Type: Application
    Filed: January 25, 2016
    Publication date: July 27, 2017
    Inventors: William A. Yirava, Nicole M. Beahn, Phillip Franciskovich, Tricia Cregger
  • Publication number: 20170211036
    Abstract: The present invention provides a process of cultivating microalgae and a joint method of same jointed with denitration. During the microalgae cultivation, EM bacteria is added into the microalgae suspension. In the nutrient stream for cultivating microalgae, at least one of the nitrogen source, phosphorus source and carbon source is provided in the form of a nutrient salt. During the cultivation, the pH of the microalgae suspension is adjusted with nitric acid and/or nitrous acid. The joint method includes (1) a step of cultivating microalgae; (2) a separation step of separating a microalgae suspension obtained from step (1) into a wet microalgae (microalgae biomass) and a residual cultivation solution; and (3) a NOx absorbing/immobilizing step of denitrating an industrial waste gas with the residual cultivation solution obtained from step (2). The nutrient stream absorbed with NOx obtained from step (3) is used to provide nitrogen source to the microalgae cultivation of step (1).
    Type: Application
    Filed: March 17, 2015
    Publication date: July 27, 2017
    Inventors: Junfeng RONG, Xuhua ZHOU, Lin CHENG, Junying ZHU, Xugeng HUANG, Baoning ZONG
  • Publication number: 20170211037
    Abstract: The present invention aims to provide methods for producing brown algae or brown algal extracts of reduced iodine content while retaining the structures of pigment components in the brown algae. Provided is a method for producing a brown alga of reduced iodine content while retaining a pigment component in the brown alga, which method comprises shredding an untreated brown algal starting material and thereafter performing a heating treatment with hot water at 90-100° C. for 90-300 seconds. Also provided is a method for producing a brown alga of reduced iodine content while retaining a pigment component in the brown alga, wherein the brown alga obtained in the above-mentioned process is subjected to extraction using hydrous ethanol at a concentration of 60-100%.
    Type: Application
    Filed: September 29, 2015
    Publication date: July 27, 2017
    Applicant: MARUHA NICHIRO CORPORATION
    Inventors: Yosuke CHIBA, Hisashi YOSHIOKA, Takumi DAIMON, Hiroshi ODA, Masahiko SHIMADA, Kuniaki TATSUTA
  • Publication number: 20170211038
    Abstract: A method for deep dehydration and desiccation of cyanobacteria includes steps of flocculation conditioning, high pressure diaphragm plate-frame pressure filtration, quartz glass box-type desiccation and negative pressure paddle drying.
    Type: Application
    Filed: April 26, 2016
    Publication date: July 27, 2017
    Inventors: Bo Bian, Binbin Fang, Lingjun Zhou, Haisuo Wu, Qin Zhang, Weili Jiang, Wei Cheng, Yamin Fan
  • Publication number: 20170211039
    Abstract: A method of making retinal ganglion cells, comprises the steps of: (a) differentiating pluripotent stem cells into retinal progenitor cells; and, (b) differentiating retinal progenitor cells into retinal ganglion cells.
    Type: Application
    Filed: May 5, 2015
    Publication date: July 27, 2017
    Inventors: Sarah K. Ohlemacher, Jason S. Meyer
  • Publication number: 20170211040
    Abstract: According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region of the tissue that includes a selected type of stem cell, by expressing the microbial opsin in the stem cell. A light source is then introduced near the stem cell, and the light source is used to controllably activate thejight source to direct pulses of illumination from the light source to the selected type of stem cell, for selectively controlling the growth and development of the stem cell in a manner that is independent of the growth and development of the other types of cells.
    Type: Application
    Filed: March 21, 2017
    Publication date: July 27, 2017
    Inventors: Karl Deisseroth, Albrecht Stroh, M. Bret Schneider, Raag D. Airan
  • Publication number: 20170211041
    Abstract: Provided herein are methods and assays for isolating and culturing seborrheic keratosis cells ex vivo. Also provided herein are screening assays using cultured seborrheic keratosis cells and methods for treating seborrheic keratosis in a subject.
    Type: Application
    Filed: April 10, 2017
    Publication date: July 27, 2017
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Anna I. Mandinova, Sam W. Lee, Victor A. Neel
  • Publication number: 20170211042
    Abstract: The present invention provides methods and compositions for converting a T cell into a cell that exhibits at least one regulatory T cell phenotype. The converted T cell is generated by contacting a T cell with a cell that is modified to comprise an agent capable of activating PD1 signaling in a T cell. The converted T cell is useful for preventing, suppressing, blocking or inhibiting an immune response. For example the converted T cell is useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft versus host disease. The converted T cell can also be used to treat autoimmune diseases.
    Type: Application
    Filed: March 31, 2017
    Publication date: July 27, 2017
    Inventors: James L. Riley, Daniel H. Fowler, Shoba Amarnath
  • Publication number: 20170211043
    Abstract: The present invention relates to a method for in vitro production of adipocyte progenitors and adipocytes from pluripotent stem cells, in particular from induced pluripotent stem cells, as well as to the use of the adipocyte progenitors and adipocytes thus obtained for therapeutic or screening purposes.
    Type: Application
    Filed: July 28, 2015
    Publication date: July 27, 2017
    Inventors: ANNE-CLAIRE GUENANTIN, NOLWENN BRIAND, EMILIE CAPEL, CORINNE VIGOUROUX, JACQUELINE CAPEAU
  • Publication number: 20170211044
    Abstract: The invention relates to devices, methods, kits, and compositions for in vitro generation of three-dimensional micro-tissues that are accurate models of heart, skeletal muscle, neuronal, and other tissues.
    Type: Application
    Filed: August 7, 2015
    Publication date: July 27, 2017
    Inventors: Nathaniel Huebsch, Bruce Conklin, Kevin E. Healy, Peter Loskill
  • Publication number: 20170211045
    Abstract: Adipose tissue-derived stromal cells and methods of isolating and using the same. In at least one embodiment of isolated adipose tissue-derived stromal cells of the present disclosure, the cells are isolated by performing adipose tissue resection or suction on a mammalian patient, dissecting tissue obtained from said tissue resection or suction and dissociating said tissue into a cell suspension, removing adipocytes from the cell suspension, culturing the adipocyte-depleted cell suspension in EGM-2-MV media, and isolating adipose tissue-derived stromal cells secreting vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and granulocyte-colony stimulating factor (G-CSF).
    Type: Application
    Filed: January 1, 2017
    Publication date: July 27, 2017
    Inventor: Keith Leonard March
  • Publication number: 20170211046
    Abstract: A method for producing pancreatic endocrine cells, the method including introducing one or more genes of a GLIS family or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof into somatic cells.
    Type: Application
    Filed: July 3, 2015
    Publication date: July 27, 2017
    Inventors: Masahito MATSUMOTO, Yasushi OKAZAKI, Izumi SUGAHARA
  • Publication number: 20170211047
    Abstract: A method for reprogramming differentiated cells and for then converting the reprogrammed cells into a differentiated phenotype of interest by means of microfluidic technology is described, together with a related kit for cell reprogramming.
    Type: Application
    Filed: January 26, 2016
    Publication date: July 27, 2017
    Inventors: Nicola Elvassore, Camilla Luni, Stefano Giulitti
  • Publication number: 20170211048
    Abstract: The present invention concerns a method of preparing a population of iPS cells comprising reducing the amount and/or activity of one or more components of the CAF1 complex, and/or one or more components of the SUMO pathway, in a population of target cells, and (ii) optionally isolating the iPS cells from the target cell population.
    Type: Application
    Filed: July 23, 2015
    Publication date: July 27, 2017
    Inventors: Ulrich ELLING, Barbara HOPFGARTNER, Josef PENNINGER, Johannes ZUBER
  • Publication number: 20170211049
    Abstract: Nucleic acid molecules from cannabis have been isolated and characterized and encode polypeptides having cannabi-chromenic acid synthase activity. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
    Type: Application
    Filed: June 29, 2015
    Publication date: July 27, 2017
    Inventors: Jonathan E. Page, Jason M. Stout
  • Publication number: 20170211050
    Abstract: Disclosed are T7 RNA polymerase variants with enhanced transcriptional activity. T7 RNA polymerase variants are known which have the ability to incorporate modified ribonucleotides into growing RNA molecules. However, these variants have relatively low levels of transcriptional activity. Presented herein are mutations that increase the transcriptional activity of the variants with broad substrate range.
    Type: Application
    Filed: March 20, 2015
    Publication date: July 27, 2017
    Inventors: Andrew D. Ellington, Adam J. Meyer
  • Publication number: 20170211051
    Abstract: The invention relates to a process for the production of an enzymatic cocktail from a cellulolytic microorganism producing cellulases and/or hemi-cellulases, comprising: a step for the production of enzymes with a medium being obtained containing enzymes and a microorganism must, said must is separated, or not separated, from the liquid containing said enzymes, a step of cooling said must to a temperature below the temperature of the enzyme production step and for a time such that the beta-glucosidase concentration of the liquid originating from the cooling step is greater than that of the liquid originating from the enzyme production step, and/or the solid volume/total volume ratio is less than said ratio for the enzyme production step, and an enzymatic cocktail is obtained at the end of the cooling step.
    Type: Application
    Filed: July 27, 2015
    Publication date: July 27, 2017
    Applicant: IFP Energies nouvelles
    Inventors: Fadhel BEN CHAABANE, Etienne JOURDIER, Celine COHEN, Bernard CHAUSSEPIED
  • Publication number: 20170211052
    Abstract: The present compositions and methods relate to a beta-mannanase from Mahella australiensis, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).
    Type: Application
    Filed: September 30, 2015
    Publication date: July 27, 2017
    Inventors: Steven Le, Zhen Qian
  • Publication number: 20170211053
    Abstract: The present compositions and methods relate to a beta-mannanase from Streptococcus gallolyticus, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).
    Type: Application
    Filed: September 30, 2015
    Publication date: July 27, 2017
    Inventors: Steven Le, Zhen Qian
  • Publication number: 20170211054
    Abstract: The present compositions and methods relate to a beta-mannanase from Paenibacillus polymyxa, polynucleotides encoding the beta-mannanase, and methods of making and/or using thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).
    Type: Application
    Filed: September 30, 2015
    Publication date: July 27, 2017
    Inventors: Steven LE, Zhen QIAN
  • Publication number: 20170211055
    Abstract: Sortase molecules and methods described herein allow for the construction of a CAR or CAR member, e.g., in situ, on a CARX, e.g., CART, cell. For example, sortase mediated transfer of an antigen binding domain, e.g., a scFv, onto a CAR member having a sortase acceptor motif in place of an antigen binding domain can provide for a complete CAR member on a cell wherein the cell does not comprise nucleic acid that encodes the complete CAR member.
    Type: Application
    Filed: July 21, 2015
    Publication date: July 27, 2017
    Inventors: Jennifer Brogdon, Carla Guimaraes, John Hastewell, Andreas Loew
  • Publication number: 20170211056
    Abstract: Provided are a novel isoprene synthase derived from sweet potato and a method of preparing isoprene using the same, and more specifically, a novel isoprene synthase derived from sweet potato, a gene encoding the isoprene synthase, a host cell transformed with the gene, and a method of preparing isoprene using the same. The isoprene synthase of the present invention may have higher isoprene productivity as compared to isoprene synthases known in the related art to thereby be effectively used in isoprene biosynthesis and preparation of an isoprene polymer using the same.
    Type: Application
    Filed: July 28, 2015
    Publication date: July 27, 2017
    Inventors: Merja Oja, Anne Huuskonen, Marja Iimen, Laura Ruohonen, Outi Koivistoinen, Simon Moon Geun Jung, Jae Hoon Jo, Sang Min Lee
  • Publication number: 20170211057
    Abstract: The present invention relates to a vector comprising a polynucleotide encoding a modified glutamine synthetase (GS), and a method for preparing a target protein employing the same. More particulary, the present invention relates to a modified GS having an increased sensitivity to a glutamine synthetase (GS) inhibitor, a polynucleotide encoding the modified GS, a vector comprising the polynucleotide, a transformat comprising the vector, and a method for preparing a target protein using the transformat.
    Type: Application
    Filed: January 5, 2017
    Publication date: July 27, 2017
    Inventors: Hyun Sook Jang, Dong Heon Lee, Sun Kyu Kim, Yong Ho Ahn, Sang Kyung Park
  • Publication number: 20170211058
    Abstract: The present invention relates to a novel method for automated processing of pooled samples, particularly blood samples. Furthermore, the present invention pertains to an apparatus for carrying out the method and the corresponding uses. The method, and accordingly, the apparatus, can be used in particular to perform nucleic acid amplification techniques (NAT) for testing blood donations and blood products.
    Type: Application
    Filed: August 5, 2015
    Publication date: July 27, 2017
    Inventors: WILLI KURT ROTH, STEFANIE KERN
  • Publication number: 20170211059
    Abstract: Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-celluar fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.
    Type: Application
    Filed: March 20, 2017
    Publication date: July 27, 2017
    Inventors: Erik Leeming Kvam, John Richard Nelson, Gregory Andrew GROSSMANN, Ryan Charles Heller, Erin Jean Finehout, Christopher Michael Puleo, William Patrick Waters
  • Publication number: 20170211060
    Abstract: The present invention relates to vectors, methods and systems for polypeptide display and selection. Specifically, the present invention relates to vectors, methods, and systems for multivalent phage display using pIX protein of filamentous phage and helper phage.
    Type: Application
    Filed: January 13, 2017
    Publication date: July 27, 2017
    Inventors: Geir Age Loset, Inger Sandlie
  • Publication number: 20170211061
    Abstract: The disclosure provides novel large serine recombinases and their respective recognition sites, as well as libraries of orthogonal recombinase recognition sites. Uses of the large serine recombinases, recognition sites, and libraries of orthogonal recombinase recognition sites also are provided.
    Type: Application
    Filed: January 20, 2017
    Publication date: July 27, 2017
    Applicants: Massachusetts Institute of Technology, INRIA (French Institute for Research in Computer Science and Automation)
    Inventors: RON WEISS, Xavier Cesar Duportet, Gregory Batt, Yinqing Li
  • Publication number: 20170211062
    Abstract: The present disclosure provides compositions comprising an antisense oligonucleotide and one or more excipients that modulates viscosity, turbidity or both viscosity and turbidity. In certain embodiments, compositions comprising an antisense oligonucleotide and one or more excipients having low viscosity are provided. In certain embodiments, compositions comprising an antisense oligonucleotide and one or more excipients having low turbidity are provided. In certain embodiments, pharmaceutical compositions comprising an antisense oligonucleotide and one or more excipients having low viscosity and turbidity are provided.
    Type: Application
    Filed: October 14, 2016
    Publication date: July 27, 2017
    Applicant: Ionis Pharmaceuticals, Inc.
    Inventors: Andrew Dibble, Lloyd Tillman, Bret Coldren, Marc Lim
  • Publication number: 20170211063
    Abstract: The object of the present invention is to provide a production system that is capable of high-level secretory production of a protein (and in particular, a protein with a complicated structure such as a structure with S—S bonds) in a host cell such as yeast and is suitable for industrial production with high safety that does not require explosion-proof facilities. The present invention provides a transformed yeast into which a chaperone gene has been introduced and in which the aox1 gene and/or the protease gene have been disrupted and a method for producing a protein involving the use of such transformed yeast.
    Type: Application
    Filed: July 29, 2015
    Publication date: July 27, 2017
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Koichi NONAKA, Takeshi SUZUKI, Masashi TSUDA, Satoshi BABA, Kimihisa ICHIKAWA, Yasunori CHIBA, Takehiko YOKO-O, Rie ITO
  • Publication number: 20170211064
    Abstract: Disclosed herein are methods for reducing expression of Tau mRNA and protein in an animal with Tau antisense compounds. Also disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds. Such methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof. Examples of neurodegenerative diseases that can be treated, prevented, and ameliorated with the administration Tau antisense oligonucleotides include Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP-17, Progressive Supranuclear Palsy, Chronic Traumatic Encephalopathy, Epilepsy, and Dravet's Syndrome.
    Type: Application
    Filed: July 29, 2015
    Publication date: July 27, 2017
    Applicant: Ionis Pharmaceuticals, Inc.
    Inventor: Frank Rigo
  • Publication number: 20170211065
    Abstract: The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties.
    Type: Application
    Filed: January 26, 2017
    Publication date: July 27, 2017
    Applicant: RaNA Therapeutics, Inc.
    Inventors: Eugen Uhlmann, Markus Weber, Romesh Subramanian, Thomas Dino Rockel, Arthur M. Krieg
  • Publication number: 20170211066
    Abstract: Methods and compositions for the treatment of prostate associated disorders are disclosed.
    Type: Application
    Filed: April 6, 2017
    Publication date: July 27, 2017
    Applicants: The Ohio State University Research Foundation, The Government of the United States of America, as represented by the Secretary of the Department of
    Inventors: Carlo M. Croce, Stefan Ambs
  • Publication number: 20170211067
    Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.
    Type: Application
    Filed: July 31, 2015
    Publication date: July 27, 2017
    Applicants: Academia Sinica, National Taiwan University, Taipei Medical University
    Inventors: Konan Peck, Pan-Chyr Yang, Yi-Chung Chang, Bo-Tsang Huang, Shauh-Der Yeh
  • Publication number: 20170211068
    Abstract: The present invention relates to an immunostimulating agent comprising at least one chemically modified RNA. The invention furthermore relates to a vaccine which comprises at least one antigen in combination with the immunostimulating agent. The immunostimulating agent according to the invention and the vaccine according to the invention are employed in particular against infectious disease or cancer diseases.
    Type: Application
    Filed: January 26, 2017
    Publication date: July 27, 2017
    Applicant: CureVac AG
    Inventors: Ingmar HOERR, Florian VON DER MÜLBE, Steve PASCOLO
  • Publication number: 20170211069
    Abstract: It is disclosed herein that cultured primary placental human trophoblast (PHT) cells are highly resistant to infection by a number of disparate viruses, and confer this resistance to non-placental recipient cells by exosome-mediated delivery of microRNAs (miRs). PHT cells express high levels of unique, primate-specific miRNAs, expressed from the chromosome 19 miRNA cluster (C19MC). It is further disclosed herein that C19MC miRNAs are packaged within PHT-derived exosomes and attenuate viral replication in recipient cells by inducing autophagy. Thus, provided herein are methods of inhibiting, treating or preventing microbial infections by administering one or more miRs of the C19MC. Also provided are methods of inducing autophagy in a cell by contacting the cell with one or more miRs of the C19MC.
    Type: Application
    Filed: January 27, 2017
    Publication date: July 27, 2017
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Yoel Sadovsky, Carolyn Coyne Candrilli
  • Publication number: 20170211070
    Abstract: The invention provides a prophylactic agent or therapeutic agent for fibrodysplasia ossificans progressiva, containing as an active ingredient a binding inhibitor that inhibits interaction between activin and activin A receptor type I (ACVR1), or an expression suppressor that suppresses expression of activin.
    Type: Application
    Filed: March 30, 2015
    Publication date: July 27, 2017
    Applicants: Sumitomo Dainippon Pharma Co., Ltd., Kyoto University
    Inventors: Kyosuke Hino, Junya Toguchida, Makoto Ikeya
  • Publication number: 20170211071
    Abstract: The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Brain derived neurotrophic factor (BDNF), in particular, by targeting natural antisense polynucleotides of Brain derived neurotrophic factor (BDNF). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of BDNF.
    Type: Application
    Filed: January 4, 2017
    Publication date: July 27, 2017
    Inventors: Mohammad Ali Faghihi, Carlos Coito
  • Publication number: 20170211072
    Abstract: Provided herein are methods and compositions for inhibiting epithelial to mesenchymal transition of a cell.
    Type: Application
    Filed: June 25, 2015
    Publication date: July 27, 2017
    Inventors: Raffaella Sordella, Serif Senturk, Luca Cartegni
  • Publication number: 20170211073
    Abstract: The present invention provides an oligonucleotide having a 13- to 17-nucleotide length, which comprises a part of the sequence of SEQ ID NO: 1 or 2 having at least 8-nucleotide length, and regulates expression of YB-1, as an anti-malignant tumor agent of an artificial nucleic acid antisense (chemically modified nucleic acids-based antisense oligonucleotide that can exhibit an effect against a wide range of malignant tumors in vivo without any delivery device. The oligonucleotide preferably consists of the sequence of SEQ ID NO: 2, and has a bridged saccharide moiety type nucleoside structure, and phosphorothioate type internucleotide linkage.
    Type: Application
    Filed: July 10, 2015
    Publication date: July 27, 2017
    Inventor: Kenji Nakano
  • Publication number: 20170211074
    Abstract: Breast cancer treatment methods and materials incorporating microRNA-489 are described. The methods and materials have been developed from identification of a double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis. The methods and materials may be particularly beneficial in treatment and diagnosis of HER2 positive breast cancers.
    Type: Application
    Filed: January 20, 2017
    Publication date: July 27, 2017
    Inventors: Hexin Chen, Yogin C. Patel, Nirav R. Shah
  • Publication number: 20170211075
    Abstract: Disclosed herein are methods and compositions for inactivating TCR genes, using engineered nucleases comprising at least one DNA binding domain and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding nucleases, vectors comprising polynucleotides encoding nucleases and cells comprising polynucleotides encoding nucleases and/or cells comprising nucleases are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided.
    Type: Application
    Filed: December 15, 2016
    Publication date: July 27, 2017
    Inventors: Gary K. Lee, David Paschon, Lei Zhang
  • Publication number: 20170211076
    Abstract: This invention provides fusion proteins comprising consecutive amino acids which beginning at the amino terminus of the protein correspond to consecutive amino acids present in (i) a cytomegalovirus human MHC-restricted peptide, (ii) a first peptide linker, (iii) a human ?-2 microglobulin, (iv) a second peptide linker, (v) a HLA-A2 chain of a human MHC class I molecule, (vi) a third peptide linker, (vii) a variable region from a heavy chain of a scFv fragment of an antibody, and (viii) a variable region from a light chain of such scFv fragment, wherein the consecutive amino acids which correspond to (vii) and (viii) are bound together directly by a peptide bond or by consecutive amino acids which correspond to a fourth peptide linker, wherein the antibody from which the scFv fragment is derived specifically binds to mesothelin.
    Type: Application
    Filed: April 6, 2017
    Publication date: July 27, 2017
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Yoram REITER, Roy NOY, Kfir OVED
  • Publication number: 20170211077
    Abstract: Fungal artificial chromosome (FAC) vectors are disclosed. A vector can be replicated in a bacterial or a fungal host, and can comprise an insert of heterologous DNA up to about 500 kilobases. A vector can be used for cloning and expressing a secondary metabolite (SM) gene cluster. An insert sequence can be modified by homologous recombination. A vector can be a plasmid comprising bacterial and fungal origins of replication, as well as bacterial and fungal selection marker genes. Also disclosed are vectors that can be integrated into a fungal genome, and dual function vectors which can be replicated in a bacterial or a fungal host and can also be integrated into a fungal genome. Also disclosed are methods of generating plasmid libraries including vectors comprising intact SM gene clusters.
    Type: Application
    Filed: April 29, 2016
    Publication date: July 27, 2017
    Inventor: Cheng-Cang Charles Wu
  • Publication number: 20170211078
    Abstract: Disclosed are the nucleotide sequences of promoters from Arxula adeninivorans and Yarrowia lipolytica which may be used to drive gene expression in a cell. The promoters were validated, and selected promoters were screened to determine which promoters may be useful for increasing the lipid production efficiency of oleaginous yeasts.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 27, 2017
    Inventors: Annapurna KAMINENI, Elena E BREVNOVA
  • Publication number: 20170211079
    Abstract: The present invention relates to a transgenic plant with enhanced anthocyanin biosynthesis by the introduction of PtrMYB119 gene operably linked to a promoter, a method for preparing the transgenic plant, a method for producing anthocyanin from the transgenic plant, a composition for promoting anthocyanin biosynthesis comprising PtrMYB119 gene operably linked to a promoter, a kit for promoting anthocyanin biosynthesis comprising the composition, and a method for enhancing anthocyanin biosynthesis in a plant comprising introducing the composition into a plant for its expression. The use of the composition for enhancing anthocyanin biosynthesis provided in the present invention enables large-scale production of anthocyanins without any affect on the growth of the plant cell, which is a host, and thus the composition can be widely used for more effective production of anthocyanins.
    Type: Application
    Filed: November 17, 2016
    Publication date: July 27, 2017
    Inventors: Jae Heung Ko, Jin Seong Cho, Young Im Choi, Van Phap Nguyen