Patents Issued in October 26, 2017
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Publication number: 20170304459Abstract: The present invention provides an inhalable formulation comprising a ligand conjugated oligonucleotide and particles of a physiologically acceptable pharmacologically-inert carrier.Type: ApplicationFiled: October 7, 2015Publication date: October 26, 2017Inventors: Vasant JADHAV, Martin MAIER, Laura SEPP-LORENZINO
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Publication number: 20170304460Abstract: The present disclosure relates to a method of conjugating a compound of formula (I) with a polypeptide comprising at least one thiol group and molecules obtained from said method.Type: ApplicationFiled: October 1, 2015Publication date: October 26, 2017Inventors: Ronald James CHRISTIE, Changshou GAO, Nazzareno DIMASI
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Publication number: 20170304461Abstract: The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion —(CH2CH2O)n—, in which n is a number of six or more; and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.Type: ApplicationFiled: October 8, 2015Publication date: October 26, 2017Applicant: POLYTHERICS LIMITEDInventors: Antony Godwin, George Badescu, Matthew Bird, Penny Bryant, David Morris, Mark Frigerio
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Publication number: 20170304462Abstract: Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.Type: ApplicationFiled: September 23, 2015Publication date: October 26, 2017Applicant: Indiana University Research and Technology CorporationInventor: Yan Yu
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Publication number: 20170304463Abstract: Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous NeuroD1 in the glial cell, wherein expressing exogenous NeuroD1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous NeuroD1 to the glial cell.Type: ApplicationFiled: July 6, 2017Publication date: October 26, 2017Inventors: Gong Chen, Lei Zhang, Zheng Wu, Yuchen Chen, Fan Wang, Ziyuan Guo
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Publication number: 20170304464Abstract: The present invention relates to regulatable adeno-associated virus (AAV) vectors as well as to their use in gene therapy. It further relates to corresponding nucleic acid molecules, host cells, non-human transgenic animals, pharmaceutical compositions and kits.Type: ApplicationFiled: April 21, 2017Publication date: October 26, 2017Inventor: Sebastian KÜGLER
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Publication number: 20170304465Abstract: Provided herein are methods for treating myocilin (MYOC) glaucoma using adeno-associated viral (AAV) vectors. In some aspects, the AAV vectors encode R-spondin 1 (RSPO1), R-spondin 2 (RSPO2), R-spondin 3 (RSPO3) or R-spondin 4 (RSPO4) and/or RNAi that targets myocilin (MYOC). In one aspect, viral particles are administered to the eye of a human subject. Viral particles encoding RSPO1, RSPO2, RSPO3 and/or RSPO4 and/or MYOC RNAi are contemplated. In some aspects, variant AAV2 particles that transduce the trabecular meshwork are provided.Type: ApplicationFiled: September 16, 2015Publication date: October 26, 2017Inventors: Peter PECHAN, Abraham SCARIA, Jeffery ARDINGER
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Publication number: 20170304466Abstract: The invention relates to the field of andeno-associated virus (AAV) based gene therapy, in particular to the use of a combination of recombinant AAV-transgene vectors with an immunosuppressant and/or empty-AAV capsids. The invention further provides a composition and a kit of parts based on this combination.Type: ApplicationFiled: October 6, 2015Publication date: October 26, 2017Inventors: Jonathan D. FINN, Margarita Jacoba Bernadetta Maria VERVOORDELDONK, Paul-Peter TAK
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Publication number: 20170304467Abstract: The present invention relates in general terms to an antimicrobial composition having chlorhexidine and a dye selected from 3,7-bis(dimethylamino)-phenothiazin-5-ium chloride and a sodium or calcium salt of [4-(?-(4-diethylaminophenyl)-5-hydroxy-2, 4-disulfophenylmethylidene)-2,5-cyclohexadien-1-ylidene] diethylammonium hydroxide usable in the medical field. In particular, the invention relates to the composition in the form of aqueous solution, hydro-alcoholic solution or gel, and its use as a coloring antiseptic and disinfectant agent, for example in pre-surgical procedures.Type: ApplicationFiled: October 13, 2014Publication date: October 26, 2017Inventors: Silvio DANELUZZI, Carlo BIGNOZZI
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Publication number: 20170304468Abstract: There is provided a novel conjugate that binds to the cell surface receptor uPA (uPAR). The conjugate is based on a fluorescence-labeled peptide useful as a diagnostic probe to the surfaces of cells expressing uPAR. The conjugate is capable of carrying a suitable detectable and imageable label that will allow qualitative detection and also quantitation of uPAR levels in vitro and in vivo. This renders the surgical resection of tumors more optimal.Type: ApplicationFiled: September 3, 2015Publication date: October 26, 2017Inventors: Andreas KJAER, Morten PERSSON
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Publication number: 20170304469Abstract: The present application relates to the molecular labeling and in vivo imaging of amyloids. Specifically, the present application relates to a polypeptide-based method/vector for targeting amyloids. Such a method/vector enables the transportation of compounds or drugs across blood-brain-barrier of an individual and then binding to amyloids in brain. Particularly, the vector of the present application can transport an imaging group linked to the vector across the blood-brain-barrier, and can binds to amyloids in brain, and thus enables the labeling and imaging of amyloid deposits. When used as an imaging agent for detecting amyloid deposits in body or tissues, the vector may be labeled with suitable optical imaging groups, radioactive isotopes or imaging groups suitable for MRI or CT detection.Type: ApplicationFiled: October 24, 2014Publication date: October 26, 2017Inventors: Zhiqiang Chen, Zhou Jiangning, Chenwei Wang, Doudou Nan, Xinmeng Wang
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Publication number: 20170304470Abstract: The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.Type: ApplicationFiled: September 17, 2015Publication date: October 26, 2017Applicants: Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer CenterInventors: Mark Dunphy, Gabriela Chiosis
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Publication number: 20170304471Abstract: A subject afflicted with a cancer or precancerous condition is treated by administering an agent that increases expression of somatostatin receptors, and a cytotoxic recognition ligand. In an alternative embodiment, somatostatin analogs, which are radiolabeled are used to treat cancer or precancerous conditions.Type: ApplicationFiled: February 8, 2017Publication date: October 26, 2017Inventor: Jeffrey P. Norenberg
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Publication number: 20170304472Abstract: This invention relates to a method, process and apparatus for disinfecting and sterilizing all types of surfaces contaminated with microorganisms and toxic substances to render both inactive. Furthermore, this invention relates to both a method and apparatus for disinfecting and/or sterilizing breathable air and then using this air to protect a confined space from external contamination. The apparatus consists of a new ultra-violet (NUV) source that is more effective than mercury based 254 nm light for destroying DNA of virus, bacteria, spores and cists. It is most effective in breaking chemical bonds in toxic gases and Biotoxins that are useful to terrorists. It is combined with other apparatus that remove particulates and byproducts sometimes produced by the NUV source and maintains positive pressure of the confined space so as to prevent the influx of air from outside the protected zone.Type: ApplicationFiled: July 10, 2017Publication date: October 26, 2017Inventors: S. Edward Neister, John James Rowsey
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Publication number: 20170304473Abstract: Provided herein are portable ultraviolet (UV) devices, systems, and methods of use and manufacturing same. Methods of use include methods for UV disinfection and sterilization, more specifically, methods for UV disinfection and sterilization of a container, a room, a space or a defined environment. The portable UV devices, systems and methods are particularly useful for the UV disinfection and sterilization of a container, a room, a space or defined environment used in the food, beverage and dairy industry and in the process of fermentation for an alcoholic beverage. Provided are also portable UV devices, systems, and methods for inhibiting the growth of one or more species of microorganisms present in a container, a room, a space or a defined environment, preferably for inhibiting the growth of one or more species of microorganisms present on an interior surface of a container, a room, a space or a defined environment.Type: ApplicationFiled: May 23, 2017Publication date: October 26, 2017Inventors: Alexander Farren, Noah Bareket, Thomas Edgar Beard
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Publication number: 20170304474Abstract: An assembly for removing odors from items having a first container formed from a material that is at least partially ozone impervious and that defines a first interior that is accessible via a selectively closeable opening, an ozone generator that is adapted to generate and expel ozone gas from the ozone generator into the first interior of the first container, and a fastening mechanism for selectively maintaining the selectively closeable opening in a closed orientation in which the fastening mechanism prevents access to the first interior. In various embodiments, when the selectively closeable opening is in the closed orientation and the ozone generator expels ozone into the first interior of the first container, the ozone concentration in the first interior is at a concentration of between 1 ppm and 2000 ppm and the ozone leakage from the first container is between 0.01 ppm and 0.03 ppm of ozone.Type: ApplicationFiled: July 12, 2017Publication date: October 26, 2017Inventor: Daniel V. Drake
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Publication number: 20170304475Abstract: An aerosol device having a bowl with a bottom defining a drain, and a side wall extending from the bottom to a rim. A nozzle is disposed within the bowl. The nozzle defines a chamber and an outlet orifice directed toward the side wall of the bowl. The aerosol device includes a liquid container fluidly coupled to the nozzle via a first conduit having an outlet tip disposed within the chamber of the nozzle and a second conduit connecting a source of pressurized gas to the chamber of the nozzle. The outlet tip is in the form of a tube defining elongated slots communicating from inside the tube to outside the tube, the slots each having a width defined between two parallel tube surfaces. The aerosol device generates submicron liquid droplets, and is suitable for disinfecting porous articles in an enclosed volume.Type: ApplicationFiled: April 21, 2017Publication date: October 26, 2017Inventors: Eric August Frische, Christopher Benedict Spaulding, Thomas Kurt Klemann
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Publication number: 20170304476Abstract: Embodiments of the present disclosure generally relate to devices and methods for sterilizing equipment. More particularly, one or more embodiments described in the present disclosure are directed to portable devices for sterilizing medical equipment in emergency situations. The sterilization devices and method of the present disclosure address an unmet need for sterilizing surgical equipment in a manner that is not only effective and time-efficient, but is also portable and reliable enough to use in emergency medical situations in remote locations where modern sterilization equipment is not available.Type: ApplicationFiled: July 13, 2017Publication date: October 26, 2017Inventors: Daniel S. Taggart, Jessica I. McKelvie, James J. Steppan, Thomas R. Hinklin, Chett J. Boxley
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Publication number: 20170304477Abstract: A method of sterilizing medical instruments using a vacuum chamber connected to reservoir by a valve in a closed state is disclosed that includes placing instruments in a non-sterile state into a sterilization pack, opening a chamber, placing the pack into the chamber, closing the chamber, withdrawing a first volume of air from the chamber, changing a volume of liquid water into vapor, opening the valve, introducing sterilant into the chamber, introducing a second volume of air into the chamber, opening the chamber, removing the pack from the chamber, and removing the instruments in a sterile-state from the pack. The process may further include the steps of repeatedly determining pressure within the chamber, calculating second-derivative values of pressure with respect to time, and determining whether any local maxima exist in a plot of second derivative values that correspond to pressures above and/or below the triple-point pressure of water.Type: ApplicationFiled: April 26, 2016Publication date: October 26, 2017Inventors: Doug Vo Truong, Todd Morrison
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Publication number: 20170304478Abstract: A disinfectant wipe dispenser is provided comprising a container having first and second compartments, the first compartment being dimensioned to store a supply of wipes in use; and, separated by a baffle including one or more channels communicating between the compartments. The first compartment has an outlet through which wipes may be successively drawn; and, the second compartment is dimensioned to receive one or more portions of a disinfectant composition comprising a peroxy activator, a peroxy compound and optional further excipients, selected so that addition of the dosage form to a predetermined quantity of water produces a disinfectant solution containing peracetic acid at a concentration of at least about 1000 ppm. The channels communicate between the compartments and allow flow of water and aqueous disinfectant between the compartments, and have a maximum dimension configured to prevent movement of particles of disinfectant sediment from the second compartment to the first compartment.Type: ApplicationFiled: October 6, 2015Publication date: October 26, 2017Inventor: MICHAEL JOSEPH
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Publication number: 20170304479Abstract: A holder device for holding a plurality of tonometer tips or the like during a disinfection procedure has a top wall, spaced rims extending downward from the top wall to engage a support surface and hold the top wall above the support surface, and handle portions extending upwards from the top wall. The top wall has a plurality of spaced holes of predetermined diameter each configured to hold a tip extending partially through the hole with a lower end of the tip spaced above a support surface. A cover plate is releasably secured between the handle portions at a location spaced above the top wall after loading the holes with tips, and holds the tips in the holes while at least a major portion of the device is submerged in a bath of disinfectant.Type: ApplicationFiled: December 18, 2015Publication date: October 26, 2017Inventors: Richard A. STEIN, Kelly R. FOUDRAY
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Publication number: 20170304480Abstract: A waste gas scrubbing tower includes a tower body unit, a filtration unit arranged in the tower body unit, a washing unit that introduces water from an external supply into the tower body unit. The tower body unit includes division boards that define a plurality of channels through which waste gas flows, the tower body unit including a waste gas inlet opening and a waste gas outlet opening. The filtration unit includes a plurality of filter members, which are arranged in the channels. The washing unit is operable to generate water mist curtains in the channels to wash the waste gas so that the waste gas that enters the waste gas scrubbing tower is subjected to multiple times of washing and filtration and purification.Type: ApplicationFiled: April 6, 2017Publication date: October 26, 2017Inventor: YING-HAO KAO
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Publication number: 20170304481Abstract: A nonwoven web that contains a plurality of fibers formed from a polyolefm composition is provided. The polyolefin composition contains a rigid propylene polymer that has a relatively high melting temperature and modulus of elasticity, which can provide good strength and durability to the nonwoven web. The polyolefm composition also contains a ductile propylene polymer that has a relatively high melt flow index, which can help achieve relatively fine fibers that minimize the stiffness of the web. In addition to a rigid and ductile polymer, the polyolefin composition also contains a slip additive (e.g., fatty acid derivative). Among other things, such an additive can even further enhance the overall softness of the composition.Type: ApplicationFiled: November 18, 2014Publication date: October 26, 2017Inventors: Mark G. KUPELIAN, Lei HUANG, John H. CONRAD, Jeffrey J. KRUEGER, Ray A. STERLING
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Publication number: 20170304482Abstract: A polyolefin material that comprises a thermoplastic composition is provided. The composition contains a continuous phase that includes a polyolefin matrix polymer and a nanoinclusion additive dispersed within the continuous phase in the form of discrete domains. The composition further includes a beta-nucleating agent. A porous network is defined within the thermoplastic composition that includes a plurality of nanopores.Type: ApplicationFiled: November 17, 2015Publication date: October 26, 2017Inventors: Vasily A. Topolkaraev, Ryan J. McEneany, Neil T. Scholl, Antonio J. Carrillo, Mark M. Mleziva, Hristo A. Hristov, Yuriy Galabura
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Publication number: 20170304483Abstract: The present invention relates to novel formulations comprising a dry powder fibrin sealant comprised of a mixture of fibrinogen and/or thrombin, for use in the treatment of wounds or injuries, in particular for use as a topical hemostatic composition or for surgical intervention.Type: ApplicationFiled: June 26, 2017Publication date: October 26, 2017Inventors: Eliane Schutte, Linda Zuckerman, Richard Senderoff, Glen Martyn
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Publication number: 20170304484Abstract: Single layer and multi-layer anti-microbial wound care masks having a hydrophilic yarn containing silver and wound care articles are disclosed.Type: ApplicationFiled: July 7, 2017Publication date: October 26, 2017Inventors: JEFFREY MORELAND, ROGER EUGENE HUCKFELDT, DION ROSS, ERIC THOMPSON, JAMIE ASHWORTH, MICHAEL ZEDALIS, ANTHONY B. LOPEZ
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Publication number: 20170304485Abstract: Porous devices are provided that include a particle-containing fibrous porous matrix and a fluid absorbed in the particle-containing porous fibrous nonwoven matrix. The particle-containing fibrous porous matrix includes a porous fibrous nonwoven matrix containing first polyolefin fibers, second polyolefin fibers including poly(ethylene), and fiberglass fibers; and microorganism-binding particles. The microorganism-binding particles are enmeshed in said porous fibrous nonwoven matrix. Methods of debridement are provided including providing a porous device including a particle-containing fibrous porous matrix and wiping a wound or an area of skin with the device; and providing a porous device including a porous fibrous nonwoven matrix and wiping a wound with the device. Further, kits are provided including a sterile package containing at least one porous device, and typically also instructions for debridement.Type: ApplicationFiled: September 28, 2015Publication date: October 26, 2017Inventor: Manjiri T. Kshirsagar
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Publication number: 20170304486Abstract: Absorbent articles having complexed or encapsulated reactive compounds are described herein. At least two reactive compounds are complexed or encapsulated. The reactive compounds which react with some classes of malodourant compounds and do not have unpleasant odor.Type: ApplicationFiled: July 11, 2017Publication date: October 26, 2017Inventors: Timothy Alan Scavone, Misael Omar Aviles, Brian Francis Gray, Peter Christopher Ellingson, Dean Larry Duval
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Publication number: 20170304487Abstract: Body tissue and structures in an airway may be treated with an artificial scab comprising an inhomogeneous, uncohesive, solid sheet-like body comprising a granular mixture of chitosan and polysaccharide particles. The artificial scab breaks apart into smaller pieces if peeled away from the surgical site or wound, thus reducing the risk of airway occlusion.Type: ApplicationFiled: July 10, 2017Publication date: October 26, 2017Inventors: James B. Hissong, Matthew F. Myntti, Jennifer G. Medina
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Publication number: 20170304488Abstract: The present disclosure provides methods of preventing and/or reducing scar contraction by utilizing an electrospun biocompatible scaffold.Type: ApplicationFiled: November 11, 2015Publication date: October 26, 2017Inventors: Howard Levinson, Kam W. Leong, Elizabeth R. Lorden, Kyle J. Miller
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Publication number: 20170304489Abstract: The present invention relates generally to a hydrogel releasing glucose in a time-controlled manner, to medical applications thereof, and to a method for preparing said hydrogel.Type: ApplicationFiled: October 23, 2015Publication date: October 26, 2017Applicants: Centre National de la Recherche Scientifique (CNRS), Universite Paris Diderot Paris 7, Universite Cergy-Pontoise, Institut National de la Sante et de la Recherche Medicale (INSERM)Inventors: Mickael Deschepper, Hervé Petite, Delphine Logeart Avramoglou, Joseph Paquet, Emmanuel Pauthe, Laurent Bidault, Véronique Larreta Garde
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Publication number: 20170304490Abstract: A device for bone regeneration includes a fill element adapted to be inserted, during use, in a cavity present in a bone of a patient; the fill element being made of PGA fibers.Type: ApplicationFiled: September 29, 2015Publication date: October 26, 2017Inventor: Antonio SAMBUSSETI
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Publication number: 20170304491Abstract: Disclosed are a matrix for restoring soft tissue and a method of producing the same, the method including: forming a sheet-type absorption layer (11) on one side of a double layer using biocompatible neutral collagen; forming a film-type support layer (12) on the remaining surface of the double layer by mixing collagen with a water-soluble polymer and a natural material; and forming a double layer-structured matrix (10) for restoring soft tissue by attaching the absorption layer (11) and the support layer (12) so as to treat damage to soft tissue of a mammal other than a human or restore damaged soft tissue. This invention pertains to the treatment of damage to soft tissue such as tendons, ligaments, and rotator cuffs or the restoration of damaged soft tissue, whereby the quality and reliability of products can be remarkably improved, thus satisfying various needs of consumers, who are the users thereof, and exhibiting a good effect.Type: ApplicationFiled: September 29, 2014Publication date: October 26, 2017Inventors: Ki Soo KIM, Ji Chul YOO, Se Ken YEO, Sang Bum CHOI, Chang Kwon KO, Dong Sam SUH, Cheong Ho CHANG
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Publication number: 20170304492Abstract: Provided are a porous composite containing OCP and collagen having higher compressive strength than before: a bone regeneration material containing the same: and a method for producing a porous composite. The porous composite contains octacalcium phosphate and collagen, has a pore size of 5 to 40 ?m as determined by measurement using a mercury porosimeter, and contains pores of 71 to 200 ?m at a rate of less than or equal to 8% in all pores of less than or equal to 200 ?m.Type: ApplicationFiled: June 12, 2015Publication date: October 26, 2017Applicant: TOYOBO CO., LTD.Inventors: Atsushi Iwai, Fumihiko Kajii, Hidenori Tanaka
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Publication number: 20170304493Abstract: A material, especially a glassy material of pyrophosphate type, corresponding to the general formula (I): {[(M2+)1?x(R+)2x]2[(P2O74?)1?y(PO43?)4y/3]} n(H2O) in which x and y are positive rational numbers each between 0 and 0.8, and n is such that the weight percentage of water in the material is greater than 0 and less than or equal to 95. M2+ represents a bivalent ion of a metal chosen from calcium, magnesium, strontium, copper, zinc, cobalt, manganese and nickel, or any mixture of such bivalent ions. R+ represents a monovalent ion of a metal selected from potassium, lithium, sodium, and silver, or any mixture of such monovalent ions. This material in particular can be used in manufacturing of bone replacements or prosthesis coatings.Type: ApplicationFiled: September 29, 2015Publication date: October 26, 2017Inventors: JÉRÉMY SOULIE, CHRISTÈLE COMBES, CHRISTIAN REY, PIERRE GRAS
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Publication number: 20170304494Abstract: A malleable demineralized bone composition consists of cortical bone made from a first portion and a second portion. The first portion of cortical bone is made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried. The second portion of cortical bone is shaved into shavings. The shavings are long thin strips subjected to freeze-drying. The freeze-dried shavings are ground and demineralized and then freeze-dried. A volume of the second portion is placed in a solution of sterile water to create a mixture, the water volume being twice the second portion, the mixture is autoclaved under heat and pressure to form a gelatin, and the first portion is mixed with the gelatin to form a malleable putty or paste.Type: ApplicationFiled: April 22, 2016Publication date: October 26, 2017Applicant: Vivex Biomedical, Inc.Inventors: Edgar S. Maldonado, Silvia Daniela Gonzales
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Publication number: 20170304495Abstract: A bone gel composition consists of cortical bone. The cortical bone is made from cut pieces freeze-dried then ground into particles and demineralized then freeze-dried. A volume of the particles is placed in a solution of sterile water to create a mixture, the water volume being at least twice the particle volume, the mixture is autoclaved under heat and pressure to form a gelatin, the resulting bone gel is formed into sheets having a thickness (t).Type: ApplicationFiled: August 15, 2016Publication date: October 26, 2017Applicant: Vivex Biomedical, Inc.Inventors: Wendy W. Weston, Silvia Daniela Gonzales, Edgar S. Maldonado
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Publication number: 20170304496Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: ApplicationFiled: July 6, 2017Publication date: October 26, 2017Inventors: David Knaack, John Winterbottom, David R. Kaes, Todd M. Boyce, Lawrence A. Shimp
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Publication number: 20170304497Abstract: Methods for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall are disclosed. In one aspect the method includes providing a bioprosthetic heart valve mounted on an elastical stent; treating the bioprosthetic heart valve with a tissue fixative; coating the stent and the bioprosthetic valve with a coating composition including one or more therapeutic agents; implanting the bioprosthetic valve into the vessel in a diseased natural valve site; eluting the coating composition from the bioprosthetic valve; and inhibiting stenosis, obstruction and/or calcification of the bioprosthetic heart valve by preventing the attachment of stem cells to the bioprosthetic heart valve, the stem cells circulating external and proximate to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.Type: ApplicationFiled: May 22, 2017Publication date: October 26, 2017Inventor: Nalini M. Rajamannan
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Publication number: 20170304498Abstract: Disclosed herein are a cocoon-based, vascular patch and a method for manufacturing the same. The cocoon-based, vascular patch is manufactured by dividing a cocoon into two or more fragments in a predetermined form, the cocoon having a shell having a predetermined thickness. The cocoon-based vascular patch can be relatively simply manufactured in a more cost efficient manner than conventional vascular patches, and has excellent cell growth potential and biocompatibility.Type: ApplicationFiled: September 18, 2015Publication date: October 26, 2017Applicant: REPUBLIC OF KOREA (MANAGEMENT: RURAL DEVELOPMENT ADMINISTRATION)Inventors: Hae Yong KWEON, You Young JO, Kwang Gill LEE, Hyun Bok KIM, Heui Sam LEE, Joo Hong YEO, Seok Woo KANG
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Publication number: 20170304499Abstract: The present invention relates to a peripheral nerve-specific hydrogel material, which is deliverable in a minimally invasive fashion, sustains the growth of neurons, and speeds recovery following surgical reconstruction.Type: ApplicationFiled: July 12, 2017Publication date: October 26, 2017Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Cornell UniversityInventors: Bryan Nicklaus Brown, Jonathan Cheetham
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Publication number: 20170304500Abstract: The present description relates to the discovery of materials, devices, systems and methods for microfabrication of engineered tissue scaffolds for the growth and culture of biological tissues for tissue repair, transplantation, disease treatment, regenerative medicine, drug testing or combinations thereof. The engineered tissue scaffolds mimic native conditions and structures, including, e.g., native physiology, tissue architecture, vasculature, and other properties of native tissues.Type: ApplicationFiled: October 20, 2015Publication date: October 26, 2017Inventors: Miles Montgomery, Boyang Zhang, Milica Radisic
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Publication number: 20170304501Abstract: A method for treating a medical implant uses plasma polymerization to apply a coating At least one treatment parameter is selected so that the reactive chemical groups of the coating are chemically modified to prevent an adsorption of interfering substances into the coating. An implant includes a plasma polymer coating that is biocompatible, and includes a antibiotically acting metal.Type: ApplicationFiled: October 21, 2015Publication date: October 26, 2017Inventors: Andreas Bunge, Michael Bergmann, Loic Ledernez, Josef Horak, Gerald Urban
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Publication number: 20170304502Abstract: Methods for making an osteoimplant are provided. In one embodiment the method includes applying a mechanical force to an aqueous slurry of insoluble collagen fibers to entangle the insoluble collagen fibers so as to form a semi-solid mass of entangled insoluble collagen fibers; and lyophilizing the semi-solid mass of entangled collagen fibers to form the osteoimplant. An osteoimplant containing entangled insoluble collagen fibers is also provided.Type: ApplicationFiled: April 22, 2016Publication date: October 26, 2017Inventors: Scott M. Vickers, Jeffrey L. Scifert, Mirian Gillissen, Didier Billy
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Publication number: 20170304503Abstract: An object of the present invention is to provide a cell-containing bioabsorbable tubular structure having molecular permeability, a device for manufacturing the tubular structure, and a method for manufacturing the tubular structure. According to the present invention, there is provided a tubular structure constituted with a cell structure which contains biocompatible polymer blocks and cells, in which the plurality of polymer blocks is disposed in voids between the plurality of cells.Type: ApplicationFiled: April 28, 2017Publication date: October 26, 2017Applicant: FUJIFILM CorporationInventor: Kentaro NAKAMURA
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Publication number: 20170304504Abstract: A method for treating a disease associated with tissue abnormality in a subject. The method includes administering an amount of a pharmaceutical composition to a subject in need of treating a disease associated with tissue abnormality, the pharmaceutical composition comprising a laminate comprising a fibrin gel and a cell culture. The laminate is produced by a method, which includes forming a fibrin gel layer on an upper surface of the cell culture by a reaction between fibrinogen and thrombin, wherein: the cell culture is prepared on a culture dish and the laminate of the fibrin gel and the cell culture are transferred onto a subject's heart. The laminate further includes a reinforcing portion made of a fibrin gel, the reinforcing portion formed by laminating the fibrin gel on the fibrin gel layer of the laminate of the cell culture and the fibrin gel.Type: ApplicationFiled: July 12, 2017Publication date: October 26, 2017Applicants: TERUMO KABUSHIKI KAISHA, OSAKA UNIVERSITYInventors: Fumiya OOHASHI, Ryouhei TAKEUCHI, Tadashi SAMESHIMA, Shigeru MIYAGAWA, Yoshiki SAWA, Atsuhiro SAITO
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Publication number: 20170304505Abstract: A polytetrafluoroethylene tube is provided and has a thickness of 0.1 mm or less, a tensile elongation at break of 350% or more, and a melting energy of 0.6 J/g or more which is calculated from an endothermic peak at 370° C.±5° C. in a procedure of increasing a temperature in differential scanning calorimetry (DSC).Type: ApplicationFiled: July 10, 2017Publication date: October 26, 2017Inventors: Nozomi Ohshika, Syunsuke Munakata
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Publication number: 20170304506Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.Type: ApplicationFiled: July 7, 2017Publication date: October 26, 2017Inventor: David E. Babcock
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Publication number: 20170304507Abstract: A sheet structure formed from an extracellular matrix (ECM) composition that includes acellular ECM derived from small intestine submucosa (SIS) tissue, gentamicin and vancomycin. The sheet structure is configured to modulate inflammation of damaged biological tissue and induce cell and tissue proliferation, bioremodeling of the damaged biological tissue, and regeneration of new tissue and tissue structures with site-specific structural and functional properties, when the tissue structure is delivered to the damaged biological tissue.Type: ApplicationFiled: April 25, 2017Publication date: October 26, 2017Inventor: Robert G. Matheny
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Publication number: 20170304508Abstract: A thoracic catheter system comprises a flexible thoracic catheter for inserting into a thoracic cavity of a human. A distal end of the thoracic catheter has a plurality of apertures. A proximate end of the thoracic catheter is designed to extend out of the thoracic cavity. A three way valve is one of fused with and removablely attached to the proximal end of the thoracic catheter.Type: ApplicationFiled: October 29, 2015Publication date: October 26, 2017Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Alireza JAHROMI HAMDIAN, David Hilton BALLARD, Jeffrey Adam WEISMAN, Horacio Ruben Vincent D'AGOSTINO