Abstract: An ophthalmic surgical system enabling pressure measurements proximal to the eye may include an illumination probe having a probe tip configured for insertion through an incision in an eye of a patient. The probe tip may include a distal end of an optical fiber, wherein the distal end of the optical fiber includes a first reflective surface and a second reflective surface. The first and second reflective surfaces being separated by a cavity, wherein the second reflective surface is provided by a partially transparent wall forming an exterior surface of the distal end of the optical fiber.

Abstract: A needle structure for injecting a filler and monitoring a blood backflow situation simultaneously includes a needle, a housing and a partitioning member. The needle includes a needle chamber and a needle opening connected to the needle chamber. The housing includes a housing chamber and a housing opening connected to the housing chamber, and the housing chamber is connected to the needle chamber to form a needle housing chamber. The partitioning member is disposed in the needle housing chamber. The needle housing chamber is separated into a first chamber and a second chamber by the partitioning member. The needle opening is separated into an injection opening and a blood backflow opening by the partitioning member. The first chamber is connected to the injection opening, and the blood backflow opening and the housing opening are connected by the second chamber.

Abstract: Certain exemplary embodiments comprise can comprise an auto-injector, which can comprise: a vial configured to store and/or contain an injectable medicament, the vial defining a vial longitudinal axis, and a housing comprising the vial. In various embodiments, the injectable medicament can be a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, and/or nutritional supplement that is substantially ready for injection.

Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

Abstract: A method of manufacturing one of a range of autoinjectors having cartridges (600, 600?, 600?) with different preset fill volumes, the method comprising the steps of: a) providing a front body assembly (100b, 100c, 100c?, 100c?), b) providing a cartridge (600, 600?, 600?) of given fill volume, c) providing a rear body assembly (100a) comprising a spring-driven drive ram assembly (310, 320) configured to drive the piston of a held cartridge (600, 600?, 600?), d) providing a ram spacer member (400, 400?, 400?), the ram spacer member defining a spacing geometry of length dimension (X1?, X1?, X1??, XS?, XS?, XS??, XR?, XR?, XR??) selected according to the fill volume of the cartridge (600, 600?, 600?), and e) assembling a front body assembly (100b, 100c, 100c?, 100c?), the cartridge (600, 600?, 600?), the ram spacer member (400, 400?, 400?) and the rear body assembly (100a) so that the ram spacer member (400, 400?, 400?) is arranged axially between the drive ram assembly (310, 320) of the rear body assembly (100a)

Abstract: An adapter for a syringe has a base portion having an insertion hole configured to surround and engage at least a portion of a barrel of the syringe. The base portion includes a top surface and an opposing bottom surface. At least one projection extends upwardly from the top surface of the base portion. At least one ramp portion is located proximate the at least one projection. A flange portion extends laterally outwardly from the base portion. The flange portion includes a top surface and an opposing bottom surface. The top surface of the base portion extends generally parallel to and is spaced between the top and bottom surfaces of the flange portion.

Abstract: A syringe for use in a pressurized injection of a fluid includes a syringe barrel including a polymeric material having undergone expansion via blow molding. A preform for blow molding a blow molded syringe is described, the preform including a proximal end having a retention mechanism adapted to connect to the syringe to a powered injector, a distal end having a syringe outlet section, and a barrel section between the retention mechanism and the syringe outlet section, wherein the barrel section is adapted to be blow molded to form a cylindrical wall of a syringe barrel defined between the retention mechanism and the syringe outlet section.

Abstract: The present disclosure is generally directed to a clicker arrangement for use in a drug delivery device, i.e. a handheld injection device for selecting and dispensing a number of user variable doses of a medicament. The clicker arrangement comprises a first element rotatable at least in a first direction and a second, non-rotatable element. The first element is axially displaceable relative to the second element between a first position and a second position. One of the elements comprises a clicker arm and the other comprises a protrusion wherein upon rotation of the first element in the first direction relative to the second element the clicker arm is elastically deflectable in a radial direction by the protrusion and relaxable in the opposite radial direction upon disengagement with the protrusion thereby generating an audible and/or tactile feedback signal.

Abstract: A syringe of the present disclosure has a hollow barrel fixedly and removeably coupled at one end to a needle and having an orifice at a second end. The hollow barrel also has a calibration inscription inscribed on an outer surface for identifying volumetric quantities of fluid being delivered within the hollow barrel, and the calibration inscription is a first color. The syringe of the present disclosure further has a plunger that has a compressible bulb coupled to an end of the plunger, and the compressible plunger has a second color that is different than the first color of the calibration inscription.

Abstract: The present disclosure relates to adrive mechanism for a medicament delivery device according to the disclosure comprises a compression member comprising a first cavity containing a first volume of fluid, said compression member also comprising a second cavity containing a second volume of fluid; a passage for fluid communication between the first cavity and the second cavity; a first movable piston arranged to seal the first cavity; a second movable piston arranged to seal the second cavity; wherein movement of the first movable piston or of the second movable piston, by an applied force, causes a relative change of volume between the first volume of fluid and the second volume of fluid, via a fluid flow through said passage, such that the respective second movable piston or the first movable piston is also moved.

Abstract: A drug delivery device for selecting and dispensing a number of user variable doses of a medicament.

Abstract: The present disclosure is directed to a window element and a drug delivery device, like a pen-type injector, that provides for administration by injection of medicinal products from a multidose cartridge. The drug delivery device may comprise a housing, a dose setting member, a dial, a drive member, a clutch and/or a clicker. The window element comprises a first member with a window and being made from a rigid material, a second member and a third member, each made from an elastically deformable material and being attached to the first member.

Abstract: A dose setting mechanism comprising a first element and a second element; the first element being moveable with respect to the second element; the first element and the second element being coupled by a ratchet mechanism allowing motion of the first element with respect to the second element from a first position to a second position only in a first direction while preventing motion in a second direction that is opposite to the first direction; once passing the second position, the first element being moveable with respect to the second element in the first direction and in the second direction.

Abstract: A dose setting mechanism for a medicament delivery device is presented having a pinion mounted to a locking member where the axis of rotation of the pinion is offset and parallel to the longitudinal axis of the housing containing the dose setting components. Primary and secondary dose members are engaged with the pinion to indicate a set dose of medicament.

Abstract: Various apparatuses and methods for tracking the administration of medication by medication injection devices are provided. A plunger head for a medication injection device may include a first component that houses electronic components and a second component that couples to the first component to form the plunger head. When the plunger head is installed within a barrel of the medication injection device the second component may separate the first component from medication contained within the barrel.

Abstract: The present disclosure relates to a supplementary device for attachment to an injection device including an imaging arrangement configured to capture an image of a moveable number sleeve of the injection device, a plurality of light sources, and a processor arrangement configured to control operation of the imaging arrangement and the plurality of light sources and to receive image data from the imaging arrangement. In some instances, the processor arrangement is configured to activate the plurality of light sources sequentially and to combine multiple images captured by the imaging apparatus under different illumination conditions into a single image.

Abstract: The present disclosure relates to a drive mechanism which is suitable for an injection device, especially a pen type drug delivery device and to such a drug delivery device. The mechanism comprises a spring driven rotatable drive member, a rotatable driven member, a clutch rotationally coupling the driven member and the drive member in a coupled state and allowing relative clockwise and anti-clockwise rotation between the driven member and the drive member in a decoupled state, and a spring biasing the clutch into its coupled state and allowing relative axial movement between the drive member and the driven member into the decoupled state of the clutch against the bias of the spring.

Abstract: A dispensing mechanism for delivering a dosage of medicament including a housing, a push button, a crank arm that is slideably engageable with the push button, a ram, and a ratchet gear releasably engageable with the crank arm and ram, translation of the push button along an axis causing the crank arm to engage and rotate the ratchet gear which causes the ram to distally advance relative to the housing.

Abstract: A discharger comprising a housing, a piston arranged inside the housing and being movable between a first piston position and a second piston position, a hollow cylindrical container inside the housing, the container being movable between a first container position and a second container position, a first compartment defined within the housing, a second compartment defined within the container, an axially extending passage in the interior of the piston and in communication with the first compartment and a peripheral opening of the piston in the region of a proximal end of the piston, a sealing element configured to prevent communication between the second compartment and the peripheral opening of the piston when the container is in a first container position, and a releasable retaining device configured to retain the piston in a piston first position until the container has reached a second container position.

Abstract: Apparatus is described for administering a substance to a subject. A vial contains the substance and a stopper is disposed within the vial and is slidably coupled to the vial. A first threaded element is (a) rotatable with respect to the vial and (b) substantially immobile proximally with respect to the vial during rotation of the first threaded element. A second threaded element is threadedly coupled to the first threaded element. At least a distal end of the second threaded element is substantially non-rotatable with respect to the vial, and the distal end of the second threaded element defines a coupling portion that couples the second threaded element to the stopper. The first threaded element, by rotating, linearly advances the stopper and at least the distal end of the second threaded element toward a distal end of the vial. Other embodiments are also described.

Abstract: Container holder assembly for a medicament delivery device comprising a housing part 22, a container holder 50, and a spring-biased needle guard 82, wherein the needle guard 82 is configured to disconnect from the container holder 50 upon movement from the extended position to the retracted position.

Abstract: The present invention involves a sterilizable syringe allows for reduction in needlestick injuries using conventional sterile needles. The syringe allows for direct access to and the safe removal and disposal of needles. The device consists of a sterilizable, reusable hypodermic syringe to which a disposable needle is attached, and employs carpules containing injectable medication, viewable and either manually or automatically aspirating. Some embodiments have a protective sliding mechanism consisting of an open frame bearing one or more protective collars, one at the furthermost end of the frame and an optional second one at a more proximal position. The protective mechanism may be extended to protect an exposed needle tip and retracted during an injection. With the protective mechanism extended, the needle mounting hub is exposed to allow for its exchange or removal and safe disposal.

Abstract: A needle assembly includes: a needle comprising a hollow needle tube, a needle tip at a distal end of the hollow needle tube, and a cutting face disposed adjacent to the needle tip; and a needle hub that includes a tip and a base end, and holds the needle at the needle tip. The needle hub includes a needle tip side end face from which the needle tip projects. An outer diameter of the needle is within a range of 0.15 mm to 0.20 mm, inclusive. A projection needle length extending from the needle tip side end face to the needle tip is within a range of 0.50 mm to 1.25 mm, inclusive. A needle body length extending from the needle tip side end face to a proximal end of the cutting face in within a range of 0.10 mm to 0.70 mm, inclusive.

Abstract: A set connector system for venting a gas from a fluid reservoir of a fluid infusion device is provided. The set connector system includes a connector system having a first body section coupled to a second body section. The first body section defines a bore in communication with a chamber and a counterbore of the second body section to define a fluid flow path from the fluid reservoir. The chamber of the second body section is in fluid communication with a vent subsystem defined through the second body section. The vent subsystem terminates in an outlet, and the vent subsystem directs gas in the fluid flow path through the second body section to the outlet.

Abstract: A medication injection device includes a barrel and a plunger disposed to dispense a fluid from the barrel. A dosage tracking system is coupled to output data indicative of the fluid dispensed. A controller is disposed within the medication injection device and coupled to receive the data from the dosage tracking system. The controller includes logic that when executed by the controller causes the controller to perform operations including determining, based on the data, whether an air shot event occurred while dispensing the fluid.

Abstract: A skin desensitizing device for temporarily numbing and/or cooling a surface of a subject's skin. The skin desensitizing device comprises a controller, a skin-bracing interface, and at least one overloading-neural source, which includes (i) a transcutaneous electrical nerve stimulator (TENS)-like device capable of electrically stimulating superficial skin neurons of the subject's skin into a state of fibrillation, (ii) a thermoelectric device capable of cooling the subject's skin to approximately 30° F. to 38° F., and (iii) a vibration device capable of vibrating the subject's skin to overload the skin's vibration sensors.

Abstract: A drug delivery device monitoring system is provided. The system includes a drug delivery device having a visually-identifiable feature reflecting a state or an indicia of the drug delivery device; an electronic recordation device configured to capture an image of the visually-identifiable feature and generate image data therefrom; and a computing system operable to perform image analysis on the image data to generate interpreted data therefrom. The interpreted data is provided to a stakeholder monitoring the drug delivery device.

Abstract: The present invention provides a single-dose powder inhalator and a method for the production thereof. It consists of an inhalator housing, which has a housing part (1), in which there is formed at least one medicament chamber (11) with a dose of a powdered medicament, and wherein the inhalator housing has an outlet opening (13?) and an outlet channel (13), which extends from the medicament chamber (11) to the outlet opening (13?). The outlet channel (13) is advantageously formed in the housing part (1). Also formed in the housing part (1) are an air inlet opening (12?), on a side of the medicament chamber (11) that is facing away from the outlet opening (13?), and an inlet channel (12), wherein the inlet channel (12) extends from the air inlet opening (12?) to the medicament chamber (11).

Abstract: Dispenser cap arrangements for enclosing a portion of a dispenser of a medicament are described herein.

Abstract: Method of treating an individual following a period of ischemia are provided. The methods include administering inhaled agents postconditioning to the individual and optionally simultaneously performing cardiopulmonary resuscitation. The inhaled agents include at least one noble gas.

Abstract: An oscillating positive expiratory pressure apparatus having a housing defining a chamber, a chamber inlet, a chamber outlet, a deformable restrictor member positioned in an exhalation flow path between the chamber inlet and the chamber outlet, and an oscillation member disposed within the chamber. The deformable restrictor member and the oscillation member are moveable between an engaged position, where the oscillation member is in contact with the deformable restrictor member and an disengaged position, where the oscillation member is not in contact with the deformable restrictor member. The deformable restrictor member and the oscillation member move from the engaged position to the disengaged position in response to a first exhalation pressure at the chamber inlet, and move from the disengaged position to an engaged position in response to a second exhalation pressure at the chamber inlet.

Abstract: Ventilation systems are provided. In one aspect, a ventilation system includes system includes a ventilation device that is configured to provide breathable air or gas mixture to a patient according to certain operating parameters, a memory that includes instructions, and a processor. The processor is configured to execute the instructions to receive, over a network, at least one of patient data, order data, configuration data, user data, or rules or protocols, and provide a modification of operating parameters of the ventilation device based on the received patient data, order data, configuration data, user data, or rules or protocols. Methods and machine-readable media are also provided.

Abstract: In one embodiment, a method for accurate leak estimation in a flow generation system includes measuring a total flow through the flow generation system, measuring a pressure in in the primary flow circuit of the flow generation system, determining when the measured pressure is within a predetermined threshold of EPAP, and calculating an intentional leak flowrate and an unintentional leak flowrate based on the relationship QFS(t)=QIL(t)+QUL(t) when the measured pressure is within the predetermined threshold. In another embodiment, a flow generation system includes in one embodiment an airflow generator connected in-line to a flow sensor, a pressure sensor and a patient interface connection by a first gas flow circuit, and a controller electrically coupled to the airflow generator, the flow sensor and the pressure sensor.

Abstract: A breathing assistance apparatus includes an inner volumetric member pressurizable from a first pressure to a second pressure and an outer volumetric member surrounding at least a portion of the inner expandable volumetric member. The inner volumetric member pressurizes the outer volumetric member as the inner volumetric member is pressurized from the first pressure to the second pressure. In another embodiment, a breathing assistance apparatus includes exhalation and inhalation chambers with respective biasing members providing for the exhalation chamber to apply a pressure to the inhalation chamber and thereby provide assisted inhalation. Methods for assisting breathing are also provided.

Abstract: An air delivery system for providing a supply of air from a source of air at positive pressure to an interfacing structure located at the entrance to the airways of a patient includes a manifold adapted to connect with the supply of positive air pressure and at least one tube connected to the manifold and adapted to deliver the supply of air to the interfacing structure. Each tube is structured to allow movement between an open phase in which the tube allows the passage of air and a collapsed phase in which the tube is collapsed. Each tube is structured such that weight of a typical patient's head against bedding apparel is sufficient to collapse the tube from the open phase to the collapsed phase.

Abstract: A CPAP comfort seal. The CPAP comfort seal includes a base comprising a first loop of fabric secured to a second loop of fabric, wherein the first loop of fabric and the second loop of fabric are secured to one another along a common perimeter edge. An opening is defined by an inner perimeter edge of the first loop of fabric and the second loop of fabric. An elastic band is disposed on the inner perimeter edge of the second loop of fabric. The opening is configured to receive a CPAP mask therethrough, such that elastic band contacts an outer side of the CPAP mask. The first loop of fabric contacts the wearer's face when the CPAP mask is secured thereto, providing additional sealing properties and increased comfort for the wearer.

Abstract: A mask assembly adapted for use with a positive airway pressure device, includes a mask frame, an elbow assembly provided to the frame, a cushion provided to the frame, a forehead support assembly, and a neck to connect the frame to the forehead support assembly, wherein the neck includes a pair of side walls having a streamlined design that is made to look sleek and reduce or minimize obtrusiveness. The pair of side walls may take the form of a single wall or more than two walls. The mask frame may include a recessed port structure including at least one port having access to an interior of the frame which at least in part with the cushion defines a breathing chamber in communication with a nasal passage of the patient in use. The mask frame may also include a channel to receive the cushion. The channel is formed by an outer wall and an inner wall and the channel includes an inner surface having a bead to engage with an outer surface of an edge of the cushion.

Abstract: A mask system for delivery of respiratory therapy to a patient includes a nares portion and a mouth portion and an inlet conduit connected to at least one of the nares portion and the mouth portion to deliver the pressurized, breathable gas. The mask system is adapted to selectively utilize the nares portion and/or the mouth portion in a first mode utilizing both the nares portion and the mouth portion, and in a second mode utilizing the nares portion and not utilizing the mouth portion.

Abstract: A continuous positive air pressure mask system, configured to fit around a human head, including a mask, an air inlet distribution chamber a first and second air channel and head gear. The mask configured is to fit over at least one of a nose and a mouth on the head. The air inlet distribution chamber includes an air inlet chamber and a chamber air inlet configured to connect to a continuous positive air pressure machine to receive pressurized air. The air inlet chamber includes a bottom surface contoured to fit the top of the head. The first and second air channels fluidly connect the mask to the air distribution chamber. The head gear releasably attaches to the mask to hold the mask over the at least one of a nose and a mouth.

Abstract: A strapless CPAP mask system is disclosed. The system includes a CPAP mask, a retainer attached to the CPAP mask, an oral appliance including a stem, and a connector that connects the stem of the oral appliance to the retainer, thus releasably securing the oral appliance to the CPAP mask without the use of straps.

Abstract: The invention relates to a multifunctional applicator for mobile use having an applicator plug, a supply tube, a Y-piece, fork tubes and a nose piece with prongs, wherein the applicator plug comprises a pressure chamber that has a humidifier interface for connection with a high flow therapy device, an oxygen supply port having an opening diameter of at least 1 mm, and a therapy air supply port for the supply tube, the humidifier interface and the oxygen supply port within the pressure chamber each having an upper and a lower valve seat that are provided with a seal and a valve body being movable between said valve seats and said valve body being subjected to a force by a helical compression spring from the direction of the oxygen supply port and on the other hand being pushed against the upper valve seat by an actuating element of the high flow therapy device when the applicator plug is locked in place on the high flow therapy device.

Abstract: A mount provides a structure that facilitates coupling of a nebuliser downstream of a humidifier chamber and upstream of a conduit that delivers conditioned breathing gases to a patient or user. The mount can couple together a chamber, a nebulizer and a conduit.

Abstract: A flow cassette has a housing with an inlet and an outlet and a passage therebetween. The flow cassette also has a temperature sensor disposed within the passage and configured to measure the temperature of a fluid flowing through the passage, a flow rate sensor disposed within the passage and configured to measure a flow rate of the fluid flowing through the passage, and a processor coupled to the temperature sensor and flow rate sensor. The processor is configured to accept measurements of temperature and flow rate from the temperature sensor and flow rate sensor, respectively, and provide a compensated flow rate.

Abstract: The ingestible compositions system includes the co-production of orally-ingestible compositions usable as inhalable respiratory agents including delivery apparatus and related methods.

Abstract: A dual pressure respiratory assistance device including a gas source which supplies a flow of gas into an air tube having a bubbler branch and a patient branch. A first tube that is connected to the bubbler branch is at least partially submerged in a fluid. An oscillatory relief valve cycles between first and second configurations. The relief valve includes an oscillating member which captures gas released through at least one hole in the first tube when the oscillating member is in a first position. The gas in the oscillating member causes the oscillating member to rise to a second position, wherein gas is released from the oscillating member and the at least one hole is blocked when the oscillating member reaches the second position.

Abstract: A sleep inducing device and a sleep management system including the same are provided. The sleep inducing device comprises: a housing unit that includes a frame of which the shape can be changed; a sensor unit that is disposed on one surface of the housing unit and includes a brain-wave measurement sensor that measures a user's brain wave; an output unit that includes a first output unit and a second output unit, wherein the first output unit is located on one side of the housing unit to output a sound or light with a first frequency, and the second output unit is located on an opposite side of the housing unit to output a sound or light with a second frequency that is different from the first frequency; and a control unit that calculates the user's sleep pattern on the basis of the brain wave signal measured by the sensor unit and changes the output signal of the output unit such that the sleep pattern approaches a predetermined value.

Abstract: A sleep improvement system includes a lifestyle pattern generator configured to generate a lifestyle pattern from at least one of sleep information about sleep of a user, lifestyle information about the user, and living condition information about the user.

Abstract: A peripheral catheter having a catheter tip diffuser for reducing an exit velocity of an infusant within the catheter. Pluralities of diffusion side holes are provided on the tip portion of the catheter. Some examples further include pluralities of annularly arranged, staggered diffusion holes provided on the tip portion of an intravenous catheter to streamline infusant issued from the diffusion holes. An inner surface of each diffusion hole is further angled relative to the inner surface of the catheter lumen such that an infusant within the lumen exits the catheter though the diffusion holes at an angle less than 90°.

Abstract: A system includes a delivery catheter and a separately-packaged implantable medical device assembly. The assembly includes a relatively compact implantable medical device, a support shaft, a tether, and a snare mandrel. The tether, which extends in the support shaft, has a distal portion coupled to the device, at a distal end of the support shaft, and a proximal portion protruding from a proximal end of the support shaft, for engagement by a hook of the snare mandrel. An operator may use the engaged snare mandrel to pull the support shaft into a lumen of an inner shaft of the catheter so that the coupled device comes into engagement with a flared end of the catheter inner shaft. Then, after locking the proximal portion of the tether within the catheter, the operator may advance a receptacle of the catheter over the device.

Abstract: The invention relates to a catheter device, having a catheter (1), an actuation device (8) at a first end of the catheter and also a mechanical transmission clement (9, 10) for transmitting a movement along the catheter to the actuation device, the actuation device having a coupling clement (14) which is connected to the transmission clement (9, 10) and can be actuated by the latter relative to the longitudinal direction of the catheter in a first degree of freedom, and also a conversion element (15) which can be actuated by the coupling element and which converts the actuation movement at least partially into a movement in a second degree of freedom. As a result, a combined movement at the distal end of the catheter can be produced particularly simply for compression and release of a functional element.