Patents Issued in December 7, 2017
  • Publication number: 20170350817
    Abstract: In general, this disclosure is directed to a flexible or stretchable sensor and a method of detecting a substance and/or electromagnetic radiation using said sensor. The sensor comprises a flexible or stretchable substrate, a pair of terminal electrodes disposed on the flexible or stretchable substrate in mutually spaced apart and opposing relation, and a sensing element applied to the flexible or stretchable substrate, between and in electrical contact with the pair of terminal electrodes, wherein the sensing element is responsive to a substance and/or electromagnetic radiation impinging thereon, and wherein when a voltage is applied across the sensor, an electrical signal is generated that is proportional to a resistance value corresponding to a sensing of the substance and/or electromagnetic radiation impinging on the sensing element.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 7, 2017
    Inventors: Sharath Sriram, Madhu Bhaskaran, Philipp Gutruf
  • Publication number: 20170350818
    Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.
    Type: Application
    Filed: June 1, 2017
    Publication date: December 7, 2017
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Ali Kabiri, Gerard Schmid, Keith G. Fife, James Beach, Jason W. Sickler, Lawrence C. West, Paul E. Glenn, Kyle Preston, Farshid Ghasemi, Benjamin Cipriany, Jeremy Lackey
  • Publication number: 20170350819
    Abstract: A surface enhanced Raman scattering (SERS) active nanoassembly comprising anisotropically assembled gold nanoparticles in a monolayer double row immobilized on a glass layer is disclosed. The discrete gold nanoparticles are separated by interparticle gaps of 0.5-10 nm that provide hotsites where appropriate excitation creates surface plasmon resonaces and regions of strong and localized electromagnetic fields that enhance Raman signal substantially, 104-1015 fold. An appropriate SERS apparatus comprising the nanoassembly for detecting an analyte is also disclosed. In addition, a method for producing the nanoassembly as well as the application of the nanoassembly or the apparatus comprising the nanoassembly in a method for measuring the SERS signal of an analyte is disclosed.
    Type: Application
    Filed: August 22, 2017
    Publication date: December 7, 2017
    Applicant: King Fahd University of Petroleum and Minerals
    Inventors: Mohammad Kamal HOSSAIN, Yukihiro OZAKI
  • Publication number: 20170350820
    Abstract: The present invention relates generally to the field of microelectronics, and more particularly to a structure and method of forming a biosensor having a nucleotide attracting surface tailored to reduce false detection of nucleotides and enabling optical detection of nucleotides. The biosensor may include an analyte-affinity layer on an upper surface of a dielectric layer. The analyte-affinity layer may include a plurality of cylindrical gold portions with dimensions tailored for a target analyte. A distance between adjacent portions of the plurality of portions may range from approximately 50% of a length of a target analyte to approximately 300% of a length of a target analyte. The plurality of portions of the analyte-affinity layer have an upper surface with a diameter ranging from approximately 3 nm to approximately 20 nm.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 7, 2017
    Inventors: Robert L. Bruce, Payel Das, HsinYu Tsai, Sufi Zafar
  • Publication number: 20170350821
    Abstract: A test device is configured for diagnostic testing and includes an optical readable medium, in turn including a pattern of spots of material arranged on a surface of the device. Several patterns may be provided. The patterns accordingly formed may be human and/or machine readable. They may notably encode security information, e.g., indicating whether the device has already been used. The spots may notably be inkjet spotted. In addition, a method is provided for decoding information encoded in a pattern of such a test device. In embodiments, liquid is introduced in the device, which comprises additional spots having a substantially different solubility than spots forming the actual pattern. Thus, the additional spots get solubilized in and flushed by the liquid as the latter wets them, and an initially hidden pattern may be read, which is formed of the remaining spots (not solubilized). Encoding methods are also provided.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 7, 2017
    Inventors: Emmanuel Delamarche, Onur Goekce, Yuksel Temiz
  • Publication number: 20170350822
    Abstract: An apparatus and method comprising: a plurality of sensor elements wherein the sensor elements are configured to be actuated in response to exposure to a parameter and the apparatus is configured to record when each of the sensor elements are actuated wherein: the plurality of sensor elements comprises at least a first subset of sensor elements and at least a second subset of sensor elements where the first subset of sensor elements are actuated in response to a first level of exposure to a parameter and the second subset of sensor elements are actuated in response to a second level of exposure to a parameter.
    Type: Application
    Filed: July 30, 2015
    Publication date: December 7, 2017
    Inventors: Chris BOWER, Darryl COTTON, Mark ALLEN, Michael ASTLEY, Joseph BOTTOMLEY
  • Publication number: 20170350823
    Abstract: Methods and apparatus for determining levels of gaseous elements and optionally utilizing the determined levels to calibrate one or more sensors of an air purifier. For example, in some implementations a first image is captured of a colorimetric sensor device at the start of a sensing period and a second image is captured of the colorimetric sensor device at the end of the sensing period. The colorimetric sensor device includes at least one colorimetric sensor configured to change colors in response to reaction with a gaseous pollutant. Values may be determined based on the colors of the colorimetric sensor in the first and second images and the values may be utilized to determine a pollution value indicative of the amount of the gaseous pollutant to which the colorimetric sensor was exposed during the sensing period.
    Type: Application
    Filed: December 18, 2015
    Publication date: December 7, 2017
    Inventors: DECLAN PATRICK KELLY, WEIZHONG CHEN
  • Publication number: 20170350824
    Abstract: The present invention relates in one aspect to a ballast water analysis system comprising fluorometer and light scattering meter. The fluorometer comprises a first light source arranged to illuminate a first ballast water sample for obtaining a first fluorescence measurement on a first ballast water sample. The light scattering meter comprises a second light source arranged to illuminate a second ballast water sample with a second light beam and first and second photodetectors arranged to receive light at respective angles relative to a direction of the second light beam. The second and third photodetectors are configured to receive scattered light resulting from interaction between light from the second light source and matter, such as viable or non-viable microorganisms and other particles, in the second ballast water sample.
    Type: Application
    Filed: November 3, 2015
    Publication date: December 7, 2017
    Applicant: Ballast Water Monitoring A/S
    Inventors: Ole Olsen, Kristoffer Kampmann
  • Publication number: 20170350825
    Abstract: An object of the present invention is to improve the quality level discrimination accuracy of the grain G by a grain quality level discrimination device. The device includes an optical unit 3 that emits light to the grain G, receives reflected and/or transmitted light from the grain G by a photosensor, and obtains information for discrimination of the quality level of the grain G from the upper and lower surface side of the grain G, and a quality level discrimination unit 7 that discriminates the quality level of the grain G on the basis of the information. The information on the upper and lower surface sides can be acquired by one optical unit at the same time so that the divergence therebetween due to the displacement or variation of the attitude of the grain G can be avoided. The reference plate for the correction of the information is placed outside of the moving path of the grain G to prevent it from soiling or damaging. Thus the deterioration of information can be avoided.
    Type: Application
    Filed: December 18, 2015
    Publication date: December 7, 2017
    Applicant: SATAKE CORPORATION
    Inventors: Hiroki ISHIZUKI, Akira ETO, Takahiro DOI, Hiroaki TAKEUCHI
  • Publication number: 20170350826
    Abstract: Provided is a method, system, and apparatus for inspecting a substrate. The method comprises illuminating the substrate with a singular laser beam, the singular laser beam forming an illuminated spot on the substrate and a bright fringe at a surface of the substrate, the bright fringe extending over at least a portion of the illuminated spot, and detecting, by an optical detection system, scattered light from nano-defects present on the substrate within the illuminated spot.
    Type: Application
    Filed: June 1, 2017
    Publication date: December 7, 2017
    Applicant: Tokyo Electron Limited
    Inventors: Xinkang TIAN, Ching-Ling MENG
  • Publication number: 20170350827
    Abstract: To facilitate adjusting of a distance from an inspection target to an illumination section by providing a movable illumination section that is movable independently of the imaging section. An illumination apparatus has a plurality of LEDs arranged in a substantially annular form, a light diffusion member for diffusing light emitted from the plurality of LEDs, and a lighting control part for lighting the plurality of light sources in accordance with a predetermined lighting pattern when designated to start lighting. In particular, the illumination apparatus moves independently of a camera to adjust a distance to a workpiece.
    Type: Application
    Filed: August 25, 2017
    Publication date: December 7, 2017
    Applicant: Keyence Corporation
    Inventor: Hajime Matsuda
  • Publication number: 20170350828
    Abstract: One or more techniques and/or systems are provided for waste object detection. For example, a waste alert component is configured to emit ultraviolet light towards a waste detection zone, such as a bathroom floor or countertop. If a waste object, such as a paper towel or other object with a fluoresce property, exists within the waste detection zone, then the waste alert component may detect an increase in light due to the waste object fluorescing visible light in response to the ultraviolet light. If the increase in light intensity exceeds a detection threshold, then the waste alert component may provide a waste detection alert that the waste object exists within the waste detection zone (e.g., a message may be sent to a housekeeper that paper towel waste in on the bathroom countertop).
    Type: Application
    Filed: August 25, 2017
    Publication date: December 7, 2017
    Inventor: Mark W. Moore
  • Publication number: 20170350829
    Abstract: Systems, methods, and apparatus are provided for determining overlay of a pattern on a substrate with a mask pattern defined in a resist layer on top of the pattern on the substrate. A first grating is provided under a second grating, each having substantially identical pitch to the other, together forming a composite grating. A first illumination beam is provided under an angle of incidence along a first horizontal direction. The intensity of a diffracted beam from the composite grating is measured. A second illumination beam is provided under the angle of incidence along a second horizontal direction. The second horizontal direction is opposite to the first horizontal direction. The intensity of the diffracted beam from the composite grating is measured. The difference between the diffracted beam from the first illumination beam and the diffracted beam from the second illumination beam, linearly scaled, results in the overlay error.
    Type: Application
    Filed: August 22, 2017
    Publication date: December 7, 2017
    Applicant: ASML Netherlands B.V.
    Inventor: Arie Jeffrey DEN BOEF
  • Publication number: 20170350830
    Abstract: Provided in some embodiments are systems and methods for measuring the water content (or water-cut) of a fluid mixture. Provided in some embodiments is a water-cut sensor system that includes a helical T-resonator, a helical ground conductor, and a separator provided at an exterior of a cylindrical pipe. The helical T-resonator including a feed line, and a helical open shunt stub conductively coupled to the feed line. The helical ground conductor including a helical ground plane opposite the helical open shunt stub and a ground ring conductively coupled to the helical ground plane. The feed line overlapping at least a portion of the ground ring, and the separator disposed between the feed line and the portion of the ground ring overlapped by the feed line to electrically isolate the helical T-resonator from the helical ground conductor.
    Type: Application
    Filed: August 25, 2017
    Publication date: December 7, 2017
    Inventors: Muhammad Akram Karimi, Atif Shamim, Muhammad Arsalan
  • Publication number: 20170350831
    Abstract: An X-ray inspecting apparatus, with which X-rays of a broad energy band can be detected while manufacturing costs are suppressed, comprises an X-ray radiation device, a line sensor assembly, and other components. The line sensor assembly has a plurality of detection units and other components. Each detection unit has a scintillator, a detection main body including a plurality of elements disposed thereon, and a ceramic substrate supporting the scintillator and detection main body. In the line sensor assembly, the plurality of detection units etc. are aligned in a forward-backward direction so that the scintillators and the detection main bodies of the detection units etc. are aligned without gaps with the scintillators and detection main bodies of adjacent detection units.
    Type: Application
    Filed: October 5, 2015
    Publication date: December 7, 2017
    Applicant: ISHIDA CO., LTD.
    Inventor: Kazuhiro SUHARA
  • Publication number: 20170350832
    Abstract: A fluid pressure loading device applied to an industrial computed tomography scanning test system includes a body, a sample accommodating chamber and at least one fluid medium chamber being provided in the body. Each of the at least one fluid medium chamber is provided therein with a piston, the corresponding fluid medium chamber is separated into two chambers by the piston, one of the two chambers is in communication with an external hydraulic medium via oil lines provided in the body, the other of the two chambers is in communication with the sample accommodating chamber, and one end, facing towards the sample accommodating chamber, of the piston is extendable into the sample accommodating chamber. With the loading device, real-time loading of a test sample can be realized, thus improving a simulation accuracy of the system, and multi-directional loading of the sample can be realized.
    Type: Application
    Filed: July 5, 2016
    Publication date: December 7, 2017
    Applicant: CHINA UNIVERSITY OF MINING AND TECHNOLOGY, BEIJING
    Inventors: Yang JU, Jianqiang WANG, Ruidong PENG, Lingtao MAO, Hongbin LIU
  • Publication number: 20170350833
    Abstract: An industrial CT scanning test system. The test system includes a test base, a multi-axis motion swivel table supported on the test base, a ray generator, an image acquisition device, and a fluid pressure loading device, and further includes a control device. The fluid pressure loading device includes at least one loading cylinder, and in case of performing a scanning experiment, the at least one loading cylinder is placed on a sample stage of the multi-axis motion swivel table together with a sample, and real-time loading of loads in different directions on the sample is performed according to test requirements.
    Type: Application
    Filed: July 5, 2016
    Publication date: December 7, 2017
    Applicant: CHINA UNIVERSITY OF MINING AND TECHNOLOGY, BEIJING
    Inventors: Yang JU, Jianqiang WANG, Ruidong PENG, Lingtao MAO, Hongbin LIU
  • Publication number: 20170350834
    Abstract: Explosives concealed within electronic devices, such as smartphones and tablet PCs, are detected using NQR spectroscopy. For example, a suspect electronic device can be placed inside a NQR scanner and be subject to interrogation electromagnetic radiation at varying frequencies. The electronic device is exposed to interrogation electromagnetic radiation at frequencies that correspond to chemical components of various explosives. In the event that an explosive chemical component is present inside the electronic device, irradiating the electronic device with interrogation electromagnetic radiation at the specific NQR frequency of that explosive chemical component will cause the explosive chemical component to emit feedback electromagnetic radiation at that frequency. Consequently, the NQR scanner can measure the feedback electromagnetic radiation and determine that the frequency of the feedback electromagnetic radiation indicates the presence of the explosive chemical component inside the electronic device.
    Type: Application
    Filed: September 4, 2015
    Publication date: December 7, 2017
    Applicant: ONE RESONANCE SENSORS, LLC
    Inventors: Pablo PRADO, James CHEPIN, Shouquin HUO, Robert LOWN, Kevin DERBY, Greg HOLIFIELD, Jonathan ZINN
  • Publication number: 20170350835
    Abstract: The integration of monolayer graphene with a semiconductor device for gas sensing applications involves obtaining a CMOS device that is prepared to receive monolayer graphene channels. After population of the monolayer graphene channels on the CMOS device, electrical contacts are formed at each end of the monolayer graphene channels with interconnect vias having sidewalls angled at less then 90°. Additional metallization pads are added at the location of the monolayer graphene channels to improve planarity and reliability of the semiconductor processing involved.
    Type: Application
    Filed: May 31, 2017
    Publication date: December 7, 2017
    Inventors: Deji Akinwande, Seyedeh Maryam Mortazavi Zanjani, Mir Mohammad Sadeghi, Milo Holt
  • Publication number: 20170350836
    Abstract: A method for determining a quantity of interest in a target comprises: providing simulated statistics of a deviation, caused by a boundary distortion in observations of the physical quantity; providing an approximate mathematical model of observations of the physical quantity, the approximate mathematical model defining the physical quantity to be dependent on the quantity of interest in the target domain, and on a deviation a boundary distortion causes in the observations, said deviation being determined to behave in accordance with the simulated statistics; receiving measured values of the physical quantity; determining an observation difference between the measured values of the physical quantity and corresponding observations according to the approximate mathematical model, and adjusting the approximate mathematical model to reduce the observation difference; and determining an estimate of the quantity of interest in the target domain on the basis of the adjusted approximate mathematical model.
    Type: Application
    Filed: January 9, 2015
    Publication date: December 7, 2017
    Applicant: ROCSOLE LTD
    Inventors: Antti NISSINEN, Marko VAUHKONEN, Ville KOLEHMAINEN, Jari KAIPIO, Anssi LEHIKOINEN, Arto VOUTILAINEN, Jouni HARTIKAINEN
  • Publication number: 20170350837
    Abstract: A method for single-molecule detection is provided and uses a carbon nanotube having a probe entity attached thereto to define a first state of the carbon nanotube. The carbon nanotube is introduced to a target entity to define a second state of the carbon nanotube. The electrical conductance of the carbon nanotube in the first and second states is compared to detect the presence of a biomolecular entity. A system for single-molecule detection including a carbon nanotube is also provided.
    Type: Application
    Filed: July 11, 2017
    Publication date: December 7, 2017
    Applicant: The Trustees Of Columbia University In the City of New York
    Inventors: Sebastian Sorgenfrei, Kenneth Shepard, Chien-Yang Chiu, Colin Nuckolls, Steven Warren
  • Publication number: 20170350838
    Abstract: To provide an electric measuring cartridge capable of decreasing a risk of contact with a connecting unit. Provided is an electric measuring cartridge at least provided with a biological sample holding unit which accommodates a biological sample, at least a pair of electrodes fixed to the biological sample holding unit, a connecting unit which electrically connects the electrodes to an external circuit, and a protecting unit which protects the connecting unit.
    Type: Application
    Filed: November 5, 2015
    Publication date: December 7, 2017
    Inventors: YOICHI KATSUMOTO, DAISUKE TERAKADO
  • Publication number: 20170350839
    Abstract: A gas sensor includes a p-type semiconductor layer that contains copper or silver cations and contacts with detection target gas, a first electrode that is a Schottky electrode to the p-type semiconductor layer, a high-resistance layer that is provided between the p-type semiconductor layer and the first electrode such that the p-type semiconductor layer and the first electrode partly contact with each other and has resistance higher than that of each of the p-type semiconductor layer and the first electrode, and a second electrode that is an ohmic electrode to the p-type semiconductor layer.
    Type: Application
    Filed: August 22, 2017
    Publication date: December 7, 2017
    Applicant: FUJITSU LIMITED
    Inventors: Satoru Momose, Osamu Tsuboi, Kazuaki Karasawa
  • Publication number: 20170350840
    Abstract: A method of assessing galvanic electronic isolation of two components at a joint of the two components includes measuring a first electrical resistance at a first condition across a joint of two components and comparing the first electrical resistance to a threshold resistance. The comparison of the first electrical resistance to the threshold resistance is indicative of a degree of electrical isolation of the two components. A second electrical resistance is measured at a second condition and the second electrical resistance is compared to the first electrical resistance. The result of the comparison of the second electrical resistance to the first electrical resistance is indicative of a type of electrical connection between the two components.
    Type: Application
    Filed: June 6, 2016
    Publication date: December 7, 2017
    Inventors: Zhongfen Ding, Mark R. Jaworowski
  • Publication number: 20170350841
    Abstract: The invention relates to detecting a composition of a sample or contamination in liquids by detecting corresponding changes in their thermal properties. In a disclosed arrangement, an apparatus is provided comprising a first probe element configured to provide a first surface in direct contact with the sample and a second surface that is not in direct contact with the sample. A measurement system measures a rate of heat transfer through the first surface. A processing unit analyses the measured rate of heat transfer in order to detect a heat transfer characteristic of the sample that is indicative of a composition of the sample.
    Type: Application
    Filed: December 16, 2015
    Publication date: December 7, 2017
    Applicant: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Kamaljit Singh CHANA, Jonathan Shamus SULLIVAN
  • Publication number: 20170350842
    Abstract: A method for identifying and measuring volume fraction constituents of a fluid using time domain analysis and frequency domain analysis to identify individual volume fraction constituents within a pipe on a real time basis and to measure the volume of the individual volume fraction constituents flowing through the pipe on a real time basis.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 7, 2017
    Applicant: Mohr and Associates
    Inventors: Charles L. Mohr, Brandt C. Mohr, Benno Mohr, Michael Stordahl, James Van Corbach, Erik Von Reis, Christopher Mulkey, Ryan Sams, David Hurley, Gordon Anderson, Daniel Kenney, William Rausch, Edgar Gilbert
  • Publication number: 20170350843
    Abstract: A probe for identifying and measuring volume fraction constituents of a fluid using time domain analysis and frequency domain analysis to identify individual volume fraction constituents within a pipe on a real time basis and to measure the volume of the individual volume fraction constituents flowing through the pipe on a real time basis.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 7, 2017
    Applicant: Mohr and Associates
    Inventors: Charles L. Mohr, Brandt C. Mohr, Benno Mohr, Michael Stordahl, James Van Corbach, Erik Von Reis, Christopher Mulkey, Ryan Sams, David Hurley, Gordon Anderson, Daniel Kenney, William Rausch, Edgar Gilbert
  • Publication number: 20170350844
    Abstract: A whole blood measurement method associated to hematocrit (HCT) and a whole blood measurement circuit thereof is applied in the detection of HCT of a whole blood sample to be tested. Herein, a time to digital converting circuit (TDC) is used for counting charging time or discharging time of a fixed capacitor and a to-be-tested sample, and a capacitance difference that is related to HCT is generated according to the charging time or the discharging time, so as to provide a reference for a whole blood feature test.
    Type: Application
    Filed: July 28, 2016
    Publication date: December 7, 2017
    Applicant: HOLTEK SEMICONDUCTOR INC.
    Inventors: Kuo-Hsiang CHEN, Kuo-Yang LI, Hung-Yu LIU
  • Publication number: 20170350845
    Abstract: An assembly comprising an upstream pipe, a downstream pipe, and a system (1) for measuring variation in the gas content of a two-phase flow, the assembly comprising: an insulating sheath (6), an upstream ground (2), a measurement electrode (3), a guard electrode (7), and a downstream ground (4) arranged in succession in said insulating sheath (6) and each presenting an identical internal section defining an internal flow duct for a two-phase flow from the upstream ground (2) towards the downstream ground (4) in line with the upstream pipe and the downstream pipe, the guard electrode (7) being subjected to the same potential as the measurement electrode (3), the measurement electrode (3) measuring the capacitance of the two-phase flow relative to the upstream ground (2) and variation in that capacitance, the upstream ground (2) and the downstream ground (4) being electrically connected to the upstream pipe and to the downstream pipe, respectively.
    Type: Application
    Filed: November 4, 2015
    Publication date: December 7, 2017
    Applicants: SAFRAN AIRCRAFT ENGINES, CAPAAB
    Inventors: Alain BRUERE, Philippe NIVET, Simon FAMMERY
  • Publication number: 20170350846
    Abstract: An integrated circuit (IC) with an impedance sensor fabricated on a surface of the substrate is disclosed. The impedance sensor includes a bottom conductive plate formed on the substrate. A sensing membrane is formed on the bottom conductive plate. A top conductive plate is formed on the sensing membrane, in which the top conductive plate is a fusion of conductive nanoparticles having a random three dimensional porosity that is permeable to a reagent.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 7, 2017
    Inventors: Benjamin Stassen Cook, Mehmet Aslan
  • Publication number: 20170350847
    Abstract: The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.
    Type: Application
    Filed: June 15, 2017
    Publication date: December 7, 2017
    Applicant: AgaMatrix, Inc.
    Inventors: Ian Harding, Sridhar G. Iyengar, Baoguo Wei, Steven Diamond, Martin Forest
  • Publication number: 20170350848
    Abstract: Methods, systems, and devices are disclosed for the identification of chemical agents and determination of their level of exposure using electrochemical detection and advanced signal processing. In one aspect, a method includes collecting a sample from a surface containing a chemical agent to an electrode on a sensor such that the chemical agent transfers on the electrode, detecting an electrochemical signal of the chemical agent on the electrode to transduce chemical information associated with the chemical agent to an electrical signal, processing the electrical signal to obtain electrochemical spectral signature data to identify the chemical agent and generating a series of coefficients of the electrochemical spectral signature data to reduce the data, and classifying the chemical information based on the series of coefficients among preselected data sets to determine a level of exposure to the chemical agent.
    Type: Application
    Filed: June 7, 2017
    Publication date: December 7, 2017
    Inventors: Joseph Wang, Joshua Ray Windmiller, Aoife O'Mahony, Xavier CetĂ³, Manel Del Valle
  • Publication number: 20170350849
    Abstract: In order to test wafers, microchips and the like, electrical and/or electrochemical properties thereof are periodically measured using electrochemical processes and are stored. The test values are compared with each other in order to determine changes in the properties. The method is carried out using an apparatus designed as a measuring cell and including a test chamber which is located between an upper half-cell and a lower half-cell and through which electrolyte is conducted. The test chamber is closed by a cell cover which simultaneously presses a wafer against an O-seal in the direction of the upper half-cell. The opening forming the test chamber in the lower half-cell is closed by an O-seal, an anode disk and an anode cover.
    Type: Application
    Filed: October 19, 2015
    Publication date: December 7, 2017
    Inventor: Markus HACKSTEINER
  • Publication number: 20170350850
    Abstract: The present disclosure relates to an electron transfer mediator comprising the osmium complex or a salt thereof, a reagent composition for an electrochemical biosensor, and an electrochemical biosensor, where the osmium compound or its salt maintains a stable oxidation-reduction form for an extended time period, a capacity to react with oxidoreductase being capable of performing the redox reaction of the target analytes, and no effect of oxygen partial pressure.
    Type: Application
    Filed: December 31, 2015
    Publication date: December 7, 2017
    Applicant: I-SENS, INC.
    Inventors: In Jun YOON, Jae Ho SHIN, Yeon Ho JUNG, Geun Sig CHA, Hakhyun NAM
  • Publication number: 20170350851
    Abstract: A measurement cell (3) for measuring at least one constituent of a liquid sample, in particular blood, includes a reception space (9) for receiving the sample includes a measurement system (8) having at least one sensor electrode (10) exposed within the reception space; a first heat supply equipment (12) extending over a first area (91); a second heat supply equipment (14) extending over a second area (93), the first and second heat supply equipment being arranged to heat the sample within the reception space (9), wherein the second area (93) is larger than the first area (91).
    Type: Application
    Filed: May 30, 2017
    Publication date: December 7, 2017
    Inventors: Werner SAUERBREY, Josef HINDINGER
  • Publication number: 20170350852
    Abstract: “Provided is a pulse operating method for an FET-type sensor having a horizontal floating electrode. The pulse operating method for an FET-type sensor includes a reading preparation step of applying one or more pre-bias voltage pulses (Vpre) to the control electrode and a reading step of applying one or more read-bias voltage pulses (VrCG) to the control electrode and applying a voltage pulse (VrDs) synchronized with the read-bias voltage pulse between a drain and a source. The reactivity and the recovery time can be improved according to the width or the magnitude of the pre-bias voltage pulse applied to the input terminal of the control electrode, and the oxidizing gas and the reducing gas can be distinguished. In addition, since current flows to the FET-type sensor only in the read-biasing period, power consumption can be greatly reduced.
    Type: Application
    Filed: June 2, 2017
    Publication date: December 7, 2017
    Inventors: Jong-Ho LEE, Jongmin Shin
  • Publication number: 20170350853
    Abstract: Provided is an FET-type sensor array. In the FET-type sensor array, a plurality of FET-type sensors are arranged at arbitrary distances from one reference point, and the same areas of the FET-type sensors are arranged to face the reference point. The FET-type sensors includes a control electrode, a floating electrode, a sensing material layer arranged between the control electrode and the floating electrode, and source and drain regions formed on both sides of a lower portion of the floating electrode. In the FET-type sensor array, through miniaturisation of FET-type sensors constituting the sensor array and new design of air layers in the peripheries of micro-heaters built in the sensors and sensing material layers, power consumption of the micro-heaters can be reduced. In addition, the sensors can be efficiently arranged to reduce the area occupied by the sensor array, and the sensing material can also be heated by the adjacent micro-heaters, so that the total power consumption can also be reduced.
    Type: Application
    Filed: June 2, 2017
    Publication date: December 7, 2017
    Inventors: Jong-Ho LEE, Yoonki HONG
  • Publication number: 20170350854
    Abstract: A molecular detection apparatus according to an embodiment includes: a distributor which ionizes a target containing substances to be detected, applies voltage to ionized substances, and extracts the substances to be detected according to a time-of-flight based on the speed; a detector which detects the substance to be detected dropped from the distributor; and a discriminator which discriminates the substance to be detected. The detector includes: a plurality of detection units including field effect transistors using graphene layers; and a plurality of organic probes which are provided on the graphene layers, and at least some of which have different bond strengths with the substances to be detected. The substance to be detected is discriminated depending on a signal pattern based on intensity differences of the detection signals generated by differences in the bond strengths between the organic probes and the substances to be detected.
    Type: Application
    Filed: August 24, 2017
    Publication date: December 7, 2017
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventors: Ko YAMADA, Hirohisa MIYAMOTO, Norikazu OSADA, Mitsuhiro OKI, Yasuko NORITOMI
  • Publication number: 20170350855
    Abstract: The present invention relates generally to the field of microelectronics, and more particularly to a structure and method of forming a biosensor having a nucleotide attracting surface formed to reduce false detection of nucleotides and enabling electrical detection of nucleotides. The biosensor may include an analyte-affinity layer on an upper surface of a substrate. A conductive layer may extend a length of the substrate below and in contact with the analyte-affinity layer. The conductive layer may be electrically connected to one or more transistors. The analyte-affinity layer may have dimensions tailored for a target analyte. A distance between a first analyte-affinity layer and a second analyte-affinity layer may range from approximately 50% of a length of a target analyte to approximately 300% of a length of a target analyte. The analyte-affinity layer may have an upper surface with a diameter ranging from approximately 3 nm to approximately 20 nm.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 7, 2017
    Inventors: Robert L. Bruce, Payel Das, HsinYu Tsai, Sufi Zafar
  • Publication number: 20170350856
    Abstract: A field effect transistor and a sensor using the field effect transistor is provided. The field effect transistor can be manufactured so as to have uniform properties by simple steps at low costs, and can stably detect, when used as a sensor, a very small amount of analyte with a high sensitivity while the properties are hardly deteriorated. A channel of the field effect transistor is constituted by a single-walled carbon nanotube thin film that is grown, by a chemical vapor deposition method, using particles of a nonmetallic material as growth nuclei, the nonmetallic material containing 500 mass ppm or less metallic impurities that contain a metal and its compounds.
    Type: Application
    Filed: August 6, 2015
    Publication date: December 7, 2017
    Applicants: NIPPON KAYAKU KABUSHIKI KAISHA, OSAKA UNIVERSITY
    Inventors: Yoshihiro KOBAYASHI, Ryota NEGISHI, Hiroto KASE, Michiharu ARIFUKU, Noriko KIYOYANAGI, Tomio MORINO
  • Publication number: 20170350857
    Abstract: An analysis chip for capillary electrophoresis includes a capillary tube, and a filter that is provided upstream of the capillary tube. The chip can also include an introducing tank connected to one end of the capillary tube, and a discharging tank connected to another end of the capillary tube.
    Type: Application
    Filed: August 24, 2017
    Publication date: December 7, 2017
    Inventor: Naotsugu ONUMA
  • Publication number: 20170350858
    Abstract: A transfer-membrane retaining jig (2) that retains a transfer membrane (1) in a separation-transfer device (100) includes: a fixing part (20, 21) that fixes at least one end in a movement direction of the transfer membrane (1), in which the fixing part (20, 21) includes an elastic body (20a, 21a) that abuts the transfer membrane (1) from an opposite side to a dispensing part (50a), and a pressing member (20b, 21b) that presses the transfer membrane (1) against the elastic body (20a, 21a).
    Type: Application
    Filed: December 7, 2015
    Publication date: December 7, 2017
    Inventors: Takateru MATSUNAGA, Hideki KINOSHITA
  • Publication number: 20170350859
    Abstract: An analysis instrument comprises plural modules connected together over a data network, each module comprising an analysis apparatus operable to perform biochemical analysis of a sample. Each module comprises a control unit that controls the operation of the analysis apparatus. The control units are addressable to select an arbitrary number of modules to operate as a cluster for performing a common biochemical analysis. The control units communicate over the data network, repeatedly during the performance of the common biochemical analysis, to determine the operation of the analysis apparatus of each module required to meet the global performance targets, on the basis of measures of performance derived from the output data produced by the modules. The arrangement of the instrument as modules interacting in this manner provides a scalable analysis instrument.
    Type: Application
    Filed: April 19, 2017
    Publication date: December 7, 2017
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Clive Gavin Brown, James Peter Willcocks
  • Publication number: 20170350860
    Abstract: The invention is related to a trapped ion mobility spectrometer (TIMS device) and proposes to use higher order (order N>2) linear multipole RF systems to accumulate and analyze ions at an electric DC field barrier, either pure higher order RF multipole systems or multipole RF systems with transitions from higher order towards lower order, e.g. from a linear octopolar RF system (N=4) to a linear quadrupole RF system (N=2) in front of the apex of the electric DC field barrier.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 7, 2017
    Inventors: Oliver RÄTHER, Thomas BETZ, Melvin Andrew PARK
  • Publication number: 20170350861
    Abstract: The invention relates to methods for the detailed analysis of ion mixtures from complex mixtures of organic substances in time-of-flight mass spectrometers which are equipped with a trapped ion mobility spectrometer, a quadrupole mass selector and a fragmentation cell. The invention proposes to analyze ion signals of a first mass mobility map, fragment ion spectra and the identifications of the associated substances as to whether ion mixtures not resolved according to mass and mobility, for example from isomers or isobars, are possibly present, and to subsequently measure the ion signals of interest with method parameters which allow the ion species to be measured separately by means of high mobility resolution.
    Type: Application
    Filed: May 25, 2017
    Publication date: December 7, 2017
    Inventors: Alexander HARDER, Markus LUBECK, Sven MYER, Detlev SUCKAU
  • Publication number: 20170350862
    Abstract: Particle measurement apparatus comprises an inlet for receiving a gas sample for analysis, a photoionisation chamber, at least one light source arranged to illuminate an interior of the photoionisation chamber, first and second electrodes coupled to a power source and configured to provide a DC potential difference across at least a portion of the photoionisation chamber, and an outlet, together defining a gas flow path from the inlet, through the photoionisation chamber, and towards the outlet.
    Type: Application
    Filed: June 6, 2017
    Publication date: December 7, 2017
    Inventors: Simone HOCHGREB, Robert NISHIDA, Adam BOIES, John SAFFELL
  • Publication number: 20170350863
    Abstract: A detection system comprising a plurality of magnetic field generators and a plurality of magnetic field detectors located adjacent to a detection area, and a control system arranged to generate magnetic field using the generators, and, for each of the generators, to make measurements of the magnetic field generated using each of the detectors, and processing means arranged to process the measurements to generate a data set characterising the detection area.
    Type: Application
    Filed: June 16, 2017
    Publication date: December 7, 2017
    Inventors: William Robert Breckon Lionheart, Anthony Peyton, Xiandong Ma
  • Publication number: 20170350864
    Abstract: A method for discovering, identifying, and monitoring of mechanical defects in a ferromagnetic underground or underwater structure. A magnetic scanner portable device is used to inspect the ferromagnetic underground structure and identify at least one portion with a magnetic field anomaly. Sets of permanent magnetic scanner sensors to monitor the magnetic field anomaly are placed adjacent to the at least one portion of the underground structure. A calculation unit, coupled to the sets of permanent magnetic scanner sensors is used to collect and process data. A stress-deformed state (SDS) and a risk-factor (RF) of the at least one portion with the magnetic field anomaly is presented on a display unit, which is coupled to the calculation unit.
    Type: Application
    Filed: July 18, 2017
    Publication date: December 7, 2017
    Inventors: Valerian GOROSHEVSKIY, Svetlana KAMAEVA, Igor KOLESNIKOV, Leonid IVLEV
  • Publication number: 20170350865
    Abstract: A magneto-inductive flow measuring device (1) comprising a measuring tube (2) on which a magnet system and two or more measuring electrodes (3) are arranged and/or secured, wherein the measuring tube (2) has in- and outlet regions (11, 12) with a first cross section and wherein the measuring tube (2) has between the in- and outlet regions (11, 12) a middle segment (10), which has a second cross section, wherein the measuring electrodes (3) are arranged in the middle segment (10) of the measuring tube (2), wherein the middle segment (10) at least in the region of the measuring electrodes (3) is surrounded by a tube holder (15), which guards against cross-sectional deformation of the second cross section.
    Type: Application
    Filed: November 18, 2015
    Publication date: December 7, 2017
    Inventors: Timo Kretzler, Daniel Kollmer
  • Publication number: 20170350866
    Abstract: A method for checking a flexible line, the flexible line including at least one layer of armors (24, 25) surrounded by an external sheath (30), the external sheath (30) delimiting an internal space (33) receiving the layer of armors (24, 25) and including at least one medium (M) at the interface between the external sheath (30) and the internal space (33). The method includes sending an ultrasonic signal on a region to be checked of the external sheath (30), and receiving the reflected signal at the interface between the region to be checked of the external sheath (30) and the internal space (33) facing the region to be checked of the external sheath (30); and analyzing the polarity of the reflected signal and determining, according to the analyzed polarity, at least the nature of the medium (M) at the interface.
    Type: Application
    Filed: December 30, 2015
    Publication date: December 7, 2017
    Inventors: Yann NICOLAS, Philippe LEMBEYE