Patents Issued in December 28, 2017
  • Publication number: 20170369398
    Abstract: A process for the dehydrogenation of alkyl-containing compounds comprises reacting an alkyl-containing compound and a Group VI nitrosyl complex characterized as a transition metal complex having the composition Cp?M(NO)(R1)(R2), wherein Cp? is selected from certain substituted and unsubstituted ?5-cyclopentadienyl groups; M is W or Mo; and R1 and R2 are independently selected from CH2C(CH3)3; CH2Si(CH3)3; CH2(C6H5); CH3; hydrogen; and ?3-allyl; provided that if R1 is hydrogen, R2 is ?3-allyl; under conditions such that the alkyl-containing compound is converted to an olefin, and in particular embodiments, a terminal olefin. The dehydrogenation can be carried out using a neat and/or undried alkyl-containing compound and/or may be conducted under air, and does not require a sacrificial olefin to drive the reaction, thereby increasing convenience and decreasing cost in comparison with some other dehydrogenation processes.
    Type: Application
    Filed: January 8, 2016
    Publication date: December 28, 2017
    Applicants: Dow Global Technologies LLC, University of British Columbia
    Inventors: Peter Legzdins, Rhett Baillie, Russ Wakeham, Devon C. Rosenfeld
  • Publication number: 20170369399
    Abstract: A process of catalytically dehydrogenating an alkane to an alkene, using Cr2O3 as a catalyst, where the catalyst is oxidized to CrO3 during the dehydrogenation, and is regenerated by using CO as a reducing gas. In regenerating the catalyst with CO, CO2 is produced, which may be fed to a dehydrogenation reactor with the alkane and reacted with H2 produced by the dehydrogenation, to form CO and H2O by the reverse water-gas shift reaction.
    Type: Application
    Filed: December 29, 2015
    Publication date: December 28, 2017
    Applicant: Sabic Global Technologies B.V.
    Inventors: YongMan Choi, Ramsey Bunama, Khalid M. El-Yahyaoui
  • Publication number: 20170369400
    Abstract: The invention is concerned with a method for producing a conjugated diene including a reaction step of subjecting a raw material gas containing a monoolefin having a carbon atom number of 4 or more to an oxidative dehydrogenation reaction with a gas containing molecular oxygen in the presence of a catalyst, to obtain a reaction product gas containing a conjugated diene; and a cooling step of cooling the reaction product gas, wherein in the cooling step, a cooling agent is supplied into a cooling column and brought into contact with the reaction product gas; the cooling agent discharged from the cooling column is then cooled by a heat exchanger; a precipitate dissolved in the cooling agent is precipitated within the heat exchanger and recovered; and the cooling agent from which the precipitate has been recovered is circulated into the cooling column.
    Type: Application
    Filed: September 8, 2017
    Publication date: December 28, 2017
    Applicant: Mitsubishi Chemical Corporation
    Inventors: Hiroki HINOISHI, Kazuyuki IWAKAI, Hiroshi KAMEO
  • Publication number: 20170369401
    Abstract: Disclosed are adsorption complexes that include 1-methylcyclopropene (1-MCP) and a metal coordination polymer network (MCPN), wherein the MCPN is a porous material, and the 1-MCP is adsorbed into the MCPN. Also disclosed are kits for containing 1-MCP that include the adsorption complex in a 1-MCP-impermeable package. Also disclosed are methods of releasing 1-methylcyclopropene (1-MCP) from the kit that include the application of aqueous fluids, heat, and/or pressure.
    Type: Application
    Filed: August 9, 2017
    Publication date: December 28, 2017
    Inventor: Nazir MIR
  • Publication number: 20170369402
    Abstract: A method for producing at least one compound of a fluorine-containing olefin compound (51) or a fluorine-containing olefin compound (52) includes performing a reaction of a fluorine-containing olefin compound (21) with an olefin compound (31) in the presence of a metal-carbene complex compound having an olefin metathesis reaction activity and an olefin compound (41) or (42).
    Type: Application
    Filed: September 1, 2017
    Publication date: December 28, 2017
    Applicant: Asahi Glass Company, Limited
    Inventor: Yusuke TAKAHIRA
  • Publication number: 20170369403
    Abstract: Disclosed is a process for the preparation of cis-1,1,1,4,4,4-hexafluoro-2-butene comprising contacting 1,1,1-trifluorotrichloroethane with hydrogen in the presence of a catalyst comprising ruthenium to produce a product mixture comprising 1316mxx, recovering said 1316mxx as a mixture of Z- and E-isomers, contacting said 1316mxx with hydrogen, in the presence of a catalyst selected from the group consisting of copper on carbon, nickel on carbon, copper and nickel on carbon and copper and palladium on carbon, to produce a second product mixture, comprising E- or Z-CFC-1326mxz, and subjecting said second product mixture to a separation step to provide E- or Z-1326mxz.
    Type: Application
    Filed: September 8, 2017
    Publication date: December 28, 2017
    Inventors: IVAN SERGEYEVICH BALDYCHEV, STEPHAN M. BRANDSTADTER, PATRICIA CHEUNG, MARIO JOSEPH NAPPA, SHENG PENG, DONALD J. TOTON
  • Publication number: 20170369404
    Abstract: The present invention is a method for purifying a fluorohydrocarbon compound comprising bringing a crude saturated fluorohydrocarbon compound having 4 or 5 carbon atoms into contact with a salt-type strongly acidic ion-exchange resin to remove water from the crude saturated fluorohydrocarbon compound. The present invention provides a method for purifying a fluorohydrocarbon compound that can sufficiently remove water from the fluorohydrocarbon compound without causing a decrease in the purity of the fluorohydrocarbon compound due to decomposition.
    Type: Application
    Filed: January 15, 2016
    Publication date: December 28, 2017
    Applicant: ZEON CORPORATION
    Inventor: Munehiro HYAKUTAKE
  • Publication number: 20170369405
    Abstract: According to one embodiment, a reduction catalyst includes a current collector including a metal layer; and organic molecules including a quaternary nitrogen cation, which are bonded to the metal layer. The organic molecules are represented by any of the following general formulae I to V.
    Type: Application
    Filed: September 7, 2017
    Publication date: December 28, 2017
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventors: Jun TAMURA, Satoshi Mikoshiba, Yuki Kudo, Akihiko Ono, Ryota Kitagawa, Masakazu Yamagiwa, Eishi Tsutsumi, Yoshitsune Sugano
  • Publication number: 20170369406
    Abstract: The present disclosure relates to a process for manufacturing 2,3-butanediol by electroreduction of 3-hydroxybutan-one in an aqueous media.
    Type: Application
    Filed: December 17, 2015
    Publication date: December 28, 2017
    Inventors: José Ramón OCHOA GÓMEZ, Alberto GARCÍA LUIS, Francisco José FERNÁNDEZ CARRETERO, Leire LORENZO IBARRETA, Soraya PRIETO FERNÁNDEZ
  • Publication number: 20170369407
    Abstract: The present invention provides a method for reducing a metal of a sugar-alcohol compound, the method including the steps of (A) protecting a hydroxyl group of a sugar-alcohol compound containing metal impurities with a protecting group, (B) removing the metal impurities from the sugar-alcohol compound having the hydroxyl group protected with the protecting group, and (C) eliminating the protecting group of the sugar-alcohol compound from which the metal has been removed. There can be provided a method for reducing a metal of a sugar-alcohol compound that can provide a sugar-alcohol compound with a suitable quality for the semiconductor apparatus manufacturing process.
    Type: Application
    Filed: May 3, 2017
    Publication date: December 28, 2017
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Takayoshi NAKAHARA, Takeru WATANABE, Seiichiro TACHIBANA, Tsutomu OGIHARA
  • Publication number: 20170369408
    Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
    Type: Application
    Filed: April 7, 2017
    Publication date: December 28, 2017
    Inventors: Thomas CHEN, Daniel LEVIN, Satish PUPALLI
  • Publication number: 20170369409
    Abstract: The present invention provides monomers, analogs, and/or derivatives of bisphenols substituted with one or more fluoromethyl groups. These monomers, analogs, and/or derivatives can be used to form oligomers and/or polymers, which in turn can be used to make compounds with dielectric properties suitable for dielectric materials, including for example, use in energy dense capacitors. In a preferred embodiment, the compounds can comprise a polycarbonate of a homopolymer, copolymer, and/or terpolymer of a bisphenol with one or more fluoromethyl substitution groups. In an aspect of the invention the compounds chosen can be selected based on various desired characteristics, including, for example, their energy density, glass transition temperature, dielectric loss, and/or dipole density.
    Type: Application
    Filed: August 23, 2017
    Publication date: December 28, 2017
    Inventors: DAVID A. BOYLES, JOHN T. BENDLER, TSVETANKA FILIPOVA
  • Publication number: 20170369410
    Abstract: The invention relates to a method of producing carbonyl compounds, more particularly C2-C4 ketones and aldehydes. The method is based on the gas-phase oxidation by nitrous oxide of C2-C4 alkane-olefin mixtures, such as a butane-butylene fraction or a propane-propylene fraction, obtained by thermal and/or catalytic cracking, to produce C2-C4 ketones and aldehydes. The process is carried out under continuous flow conditions at a temperature of 300-550° C. and pressure of 1-100 atm, without prior isolation of individual olefins from the fractionation products and in the absence of a catalyst. The process provides for high productivity, high overall selectivity for ketones and aldehydes, and explosion-safe operation.
    Type: Application
    Filed: December 4, 2015
    Publication date: December 28, 2017
    Applicant: AKTSIONERNOE OBSCHESTVO "GAZPROMNEFT - MOSKOVSKY N PZ" (AO "GAZPROMNEFT-MNPZ")
    Inventors: Alexandr Sergeevich HARITONOV, Konstantin Alexandrovich DUBKOV, Mihail Vladimirovich PARFENOV, Alexandr Stepanovich NOSKOV, Valentin Nikolaevich PARMON, Valery Alexandrovich GOLOVACHEV, Andrei Vladimirovich KLEIMENOV, Dmitry Olegovich KONDRASHEV, Valentina Dmitrievna MIROSHKINA, Petr Alexandrovich ABRASHENKOV
  • Publication number: 20170369411
    Abstract: Provided are a method for producing 3-methylglutaraldehyde in a good yield under a mild condition and a novel acetal compound which is useful for carrying out the foregoing method. The method is a production method of 3-methylglutaraldehyde including a step of hydrolyzing a compound represented by the following general formula (1): wherein R1 and R2 each independently represent an alkyl group having 1 to 6 carbon atoms, or are mutually coupled to represent an alkylene group having 2 to 6 carbon atoms.
    Type: Application
    Filed: December 17, 2015
    Publication date: December 28, 2017
    Applicant: KURARAY CO., LTD.
    Inventors: Takuo TSURUTA, Ryosuke SHIMIZU, Takahiro HOSONO, Naoya MINAMOTO
  • Publication number: 20170369412
    Abstract: A preparative method for carboxylic acids is disclosed in the present invention. The method is characterized in that: compounds (II) are reacted in the presence of hydrogen peroxide and base to produce target products (I), as represented by the following reaction scheme: wherein R1 is aryl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, benzothienyl, benzofuranyl, quinolinyl, isoquinolinyl, thiadiazolyl, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl and hydrogen; R2 is alkoxycarbonyl, alkylaminocarbonyl, aminocarbonyl, alkylthiolcarbonyl, cyano, sulfonyl, sulfinyl, carbonyl, aldehyde, carboxyl, nitro, alkyl and hydrogen; R3 is alkoxycarbonyl, alkyl amido carbonyl, aminocarbonyl, cyano, sulfonyl, sulfinyl, carbonyl, carboxyl and nitro. The present invention has the following main benefits: cheap and readily available starting materials, safe processes, high yield, good quality, which facilitates industrial production.
    Type: Application
    Filed: September 25, 2015
    Publication date: December 28, 2017
    Inventors: Yehua Su, Jieping Shi, Jianxin Lu, Tianhao Zhang, Xiaohua Yu, Guoping Cai, Bangchi Chen
  • Publication number: 20170369413
    Abstract: The invention relates to a method for separating formic acid from a reaction mixture which comprises, in addition to formic acid, a polyoxometalate ion of general formula [PMoxVyO40]n, where 6#x#11, 1#y#6, x+y=12 and 3<n<10, where n, x and y are each integers, wherein the separation occurs by means of an extraction using a linear primary alcohol, wherein the carbon chain of the alcohol comprises 5 to 12 carbon atoms, and the reaction mixture is present in a protic solvent.
    Type: Application
    Filed: January 18, 2016
    Publication date: December 28, 2017
    Applicant: OXFA GMBH
    Inventors: Jakob ALBERT, Andreas BÖSMANN, Jenny REICHERT, Peter WASSERSCHEID
  • Publication number: 20170369414
    Abstract: The invention relates to O-quinone compounds of general formula (I) as agents neutralising nitric oxide, and to the therapeutic or cosmetic use thereof.
    Type: Application
    Filed: January 12, 2015
    Publication date: December 28, 2017
    Applicant: Institut des Substances Végétales
    Inventors: Daniel Jean, Maryse Pouligon
  • Publication number: 20170369415
    Abstract: The invention relates to a process for preparing an aromatic carbonate, comprising reacting a dialkyl carbonate or an alkyl aryl carbonate with an aryl alcohol or an alkyl aryl carbonate, resulting in an aromatic carbonate which is an alkyl aryl carbonate or a diaryl carbonate, wherein a composition comprising a titanium or zirconium alkoxide or aryloxide, wherein the alkoxy group in the titanium or zirconium alkoxide is a group of formula R-0˜ wherein R is an alkyl group having 1 to 4 carbon atoms and the aryloxy group in the titanium or zirconium aryloxide is a group of formula Ar-0˜ wherein Ar is an aryl group having 6 to 12 carbon atoms, and wherein the composition additionally comprises 0.1 to 50 wt. % of an alcohol, based on the total weight of the composition, is mixed with an alcohol or an organic carbonate, and the mixture thus obtained is contacted with said dialkyl carbonate or alkyl aryl carbonate and aryl alcohol or alkyl aryl carbonate to catalyze the preparation of the aromatic carbonate.
    Type: Application
    Filed: January 14, 2016
    Publication date: December 28, 2017
    Inventors: Garo Garbis VAPORCIYAN, Kunquan YU
  • Publication number: 20170369416
    Abstract: Disclosed herein are drug release polymer compounds and compositions comprising prostacyclin compounds of Formula (I), and methods of preparing the same.
    Type: Application
    Filed: September 8, 2017
    Publication date: December 28, 2017
    Applicant: United Therapeutics Corporation
    Inventor: Peter Laing
  • Publication number: 20170369417
    Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.
    Type: Application
    Filed: September 4, 2017
    Publication date: December 28, 2017
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin
  • Publication number: 20170369418
    Abstract: Provided is a polar compound having high chemical stability, high capability of aligning liquid crystal molecules, high solubility in a liquid crystal composition, and a large voltage holding ratio when used in a liquid crystal display device. The compound is represented by formula (1): in which, for example, R1 is alkyl having 1 to 15 carbons; MES is a mesogen group having at least one ring; Sp1 is a single bond or alkylene having 1 to 10 carbons; M1 and M2 are hydrogen; and R2 is a group represented by formulas (1a) to (1c): in which, Sp2 and Spa are a single bond or alkylene having 1 to 10 carbons; S1 is >CH—; S2 is >C<; and X1 is —OH.
    Type: Application
    Filed: February 4, 2016
    Publication date: December 28, 2017
    Applicants: JNC CORPORATION, JNC PETROCHEMICAL CORPORATION
    Inventors: Hiroyuki TANAKA, Masakazu YANO, Fumitaka KONDOU, Kazuhiro OGITA
  • Publication number: 20170369419
    Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.
    Type: Application
    Filed: September 7, 2017
    Publication date: December 28, 2017
    Applicants: Complexa, Inc., University of Pittsburgh of the Commonwealth System of Higher Education
    Inventors: Bruce A. FREEMAN, Bruce BRANCHAUD
  • Publication number: 20170369420
    Abstract: The invention provides enantiopure deuterium-enriched bupropion, pharmaceutical compositions, and methods of treating neurological disorders, movement disorders, cardiovascular disorders, metabolic disorders, and other disorders using enantiopure deuterium-enriched bupropion. A preferred aspect of the invention provides methods of treating obesity and sexual dysfunction using enantiopure deuterium-enriched bupropion.
    Type: Application
    Filed: July 11, 2017
    Publication date: December 28, 2017
    Inventors: Sheila DeWitt, Vincent Jacques, Leonardus H.T. van der Ploeg
  • Publication number: 20170369421
    Abstract: The invention relates to picolinamides of Formula I and their use as fungicides.
    Type: Application
    Filed: December 21, 2015
    Publication date: December 28, 2017
    Inventors: Chenglin YAO, Kevin G. MEYER, Yu LU, Brian A. LOY, David M. JONES, Ronald J. HEEMSTRA, Jeffrey B. EPP, Johnathan E. DELORBE, Kyle A. DEKORVER, John F. DAEUBLE, Sr.
  • Publication number: 20170369422
    Abstract: The present invention provides a method for preparing a pregabalin intermediate 3-carbamoymethyl-5-methylhexanoic acid without solvent. The method comprises the following steps: a) cooling an ammonia water system to a certain temperature; b) adding 3-isobutylglutaric anhydride dropwise to the system, then keeping temperature, and reacting; c) after completing the reaction, adding an acid to the system to adjust pH; d) after adjusting pH, cooling, then keeping temperature, crystallizing, then suction filtering and drying; and e) adding a solvent to the dried substance, slurrying, and suction filtering and drying to obtain the final product. The method provided in the present invention for preparing 3-carbamoymethyl-5-methylhexanoic acid is high-yield, green, environmentally-friendly, simple and convenient, and of less pollution.
    Type: Application
    Filed: March 25, 2016
    Publication date: December 28, 2017
    Inventors: Musong Liu, Wenling Zhang, Peng Wang
  • Publication number: 20170369423
    Abstract: The present invention relates to crystalline modification of (3,4-dichlorophenyl)propanamide (propanil), to a process for the preparation of the same, to pesticidal mixtures and compositions comprising the crystalline modification of 5 (3,4-di-chlorophenyl)propanamide and to a method of combating weeds using said mixtures and compositions.
    Type: Application
    Filed: December 31, 2015
    Publication date: December 28, 2017
    Inventors: Birja SHANKER, Jaidev Rajnikant SHROFF, Vikram Rajnikant SHROFF
  • Publication number: 20170369424
    Abstract: N,N-(di)alkylaminoalkyl(meth)acrylamide or N,N-(di)alkylaminoalkyl (meth)acrylate and/or a quaternary ammonium salt thereof are prepared with a low content of a compound of formula (IV) wherein R5 in each case is a linear, branched or cyclic alkyl radical, an aryl radical which may also be substituted by one or more alkyl groups, the linear, cyclic or branched alkyl radical may have a length of 1-12 carbon atoms and is, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, hexyl, heptyl, octyl, isooctyl, nonyl, decyl, undecyl, dodecyl.
    Type: Application
    Filed: June 16, 2017
    Publication date: December 28, 2017
    Applicant: Evonik Roehm GmbH
    Inventors: Steffen KRILL, Patrik Hartmann
  • Publication number: 20170369425
    Abstract: Provided is a compound represented by Formula (1) or a salt thereof (in the formula, R1 and R2 each independently represent a hydrogen atom or a linear or branched acyl group having 11 to 30 carbon atoms, a hydrocarbon group bonded to a carbonyl carbon of the acyl group is a saturated or unsaturated hydrocarbon group, and at least one of R1 and R2 represents the acyl group).
    Type: Application
    Filed: January 15, 2016
    Publication date: December 28, 2017
    Applicant: SHOWA DENKO K.K.
    Inventors: Toru TACHIBANA, Ryota NIIBAYASHI, Daisuke YAGYU
  • Publication number: 20170369426
    Abstract: Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.
    Type: Application
    Filed: June 6, 2017
    Publication date: December 28, 2017
    Inventors: Brian D. Patterson, Qing Lu, James Bradley Aggen, Paola Dozzo, Ramesh Annasaheb Kasar, Martin Sheringham Linsell, Timothy Robert Kane, Micah James Gliedt, Darin James Hildebrandt, Glenn A. McEnroe, Frederick Cohen
  • Publication number: 20170369427
    Abstract: The present invention provides bio-based aromatic diisocyanate of formula (I). [Formula should be inserted here] wherein X is OCH3, Y is selected from —H or OCH3, and m=0-12. The present invention further provides a method for preparation of aromatic diisocyanate of formula (I) useful for preparation of polyurethane.
    Type: Application
    Filed: December 23, 2015
    Publication date: December 28, 2017
    Inventors: Prakash Purushottam WADGAONKAR, Sachin Suresh Kuhire
  • Publication number: 20170369428
    Abstract: Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula I. Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.
    Type: Application
    Filed: September 5, 2017
    Publication date: December 28, 2017
    Inventors: Eduardo M. Sotomayor, Joel A. Bergman, Alan P. Kozikowski, Alejandro V. Villagra, Karrune V. Woan
  • Publication number: 20170369429
    Abstract: The present invention discloses a method for preparing a high-purity sulfonamide compound and an intermediate of the sulfonamide compound. The method comprises the following steps: a, taking a crude product of a sulfonamide compound (I) as an initial raw material, and enabling the raw material to react with a compound of a formula (II) in presence of alkali and a catalyst so as to synthesize an intermediate of a formula (III); and b, enabling the compound represented by the formula (III) to react with alkali or acid, thereby obtaining the high-purity sulfonamide compound (I).
    Type: Application
    Filed: September 10, 2017
    Publication date: December 28, 2017
    Inventors: Xiaomin LIANG, Hao JIANG, Haige TENG, Jinzhi YANG, Junjin ZHOU, Jinlong ZHANG, Bangchi CHEN
  • Publication number: 20170369430
    Abstract: The present invention relates to oxygenated amino or ammonium-containing sulfonic acid, phosphoric acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dys-plastic disease or disorder.
    Type: Application
    Filed: September 1, 2017
    Publication date: December 28, 2017
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Publication number: 20170369431
    Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.
    Type: Application
    Filed: December 3, 2015
    Publication date: December 28, 2017
    Inventors: Wenjun ZHOU, Kyle GEE, Yolanda TENNICO, Peter SLADE, Hee Chol KANG, Shaheer KHAN, Brian EVANS, James STRAY
  • Publication number: 20170369432
    Abstract: Hydroxyl-containing bis(alkenyl) ethers can be incorporated into the backbone of polythioether prepolymers and can be used as curing agents in thiol-terminated polythioether prepolymer compositions. Cured sealants prepared using compositions containing hydroxyl-containing bis(alkenyl) ether-containing polythioether prepolymers and/or hydroxyl-containing bis(alkenyl) ether curing agents exhibit improved physical properties such as rapid curing and compatibility with fillers suitable for use in aerospace sealant applications.
    Type: Application
    Filed: June 28, 2016
    Publication date: December 28, 2017
    Inventors: WEIBIN CUI, RENHE LIN
  • Publication number: 20170369433
    Abstract: A compound which is a thienolate of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein R1, R3, Ring A1, n and Ring A2 are as defined herein, are found to be useful in inhibiting metallo-beta-lactamase and therefore in potentiating the activity of beta lactamase antibiotics. The compound can be used alone or in combination with a rhodanine of formula (II) or a pharmaceutically acceptable salt thereof: (II) wherein R3, Ring A1, n, Ring A2, L and Ring B are as defined herein. Treatment or prevention of bacterial infection in combination with beta-lactam antibiotic agents is also provided.
    Type: Application
    Filed: September 18, 2015
    Publication date: December 28, 2017
    Inventors: Jürgen Brem, Sander S. Van Berkel, Michael A. McDonough, Christopher J. Schofield
  • Publication number: 20170369434
    Abstract: Formulations comprising hydroxy methionine analog and having low levels of sulfate ions and bisulfate salts, processes for preparing the formulations, compositions comprising the formulations, and methods of using the formulations.
    Type: Application
    Filed: June 21, 2017
    Publication date: December 28, 2017
    Inventors: Matthew Mahoney, Graciela Arhancet, Xiaojun Wang, Tracy Rode, Scott Long
  • Publication number: 20170369435
    Abstract: The present invention relates to compounds for the treatment of mTOR (mammalian Target Of Rapamycin) pathway related diseases. Specifically, the present invention relates to the use of aminoacetonitrile derivatives (AADs) in the treatment of mTOR pathway related diseases.
    Type: Application
    Filed: June 5, 2017
    Publication date: December 28, 2017
    Inventors: Mohammad Hossein Pourgholami, David L. Morris, Roger Aston
  • Publication number: 20170369436
    Abstract: It is an object of the present invention to provide methods for producing vitamin D that gives improved yields and reduced side product contamination. In various aspects, these methods provide for production of vitamin-D2 using ergosterol as provitamin D2 or a dihydroxy derivative thereof as a starting material, or production of vitamin-D3 using 7-dehydrocholesterol as provitamin D3 or a dihydroxy derivative thereof as the starting material. The methods described herein comprise irradiating the starting material in a solution including an organic or inorganic base with light in the wavelength range 245-360 nanometers (nm) to obtain a product containing pre-vitamin-D2 or pre-vitamin-D3, and heating the product to convert the resulting pre-vitamin-D2 or pre-vitamin-D3 to vitamin D2 or vitamin D3. In various embodiments, these methods further comprise recovering vitamin D2 or vitamin D3 from this reaction as a purified product.
    Type: Application
    Filed: December 18, 2015
    Publication date: December 28, 2017
    Inventor: Laszlo TREIBER
  • Publication number: 20170369437
    Abstract: The invention relates to a novel process for preparing ?-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.
    Type: Application
    Filed: December 23, 2015
    Publication date: December 28, 2017
    Inventors: David MacPherson, David WITTY, Gerard GIBLIN, Michael WILLIAMS, Donald WALKER, William KIESMAN, Tamera MACK
  • Publication number: 20170369438
    Abstract: The present invention provides a method for producing an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, and an intermediate thereof. A method for producing an atropisomer of a pyrrole derivative using a compound represented by (B) [wherein R1 represents a C1-C4 alkyl group, and R2 represents a 2-hydroxyethyl group or a carboxymethyl group] as a production intermediate.
    Type: Application
    Filed: September 8, 2017
    Publication date: December 28, 2017
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Masashi Watanabe, Hiroshi Nagasawa, Noritada Sato
  • Publication number: 20170369439
    Abstract: A condensed cyclic compound represented by Formula 1: wherein in Formula 1 groups and variables are the same as described in the specification.
    Type: Application
    Filed: June 23, 2017
    Publication date: December 28, 2017
    Inventors: Yongsik JUNG, Dalho HUH, Jhunmo SON, Eunsuk KWON, Sangmo KIM, Saeyoun LEE, Soonok JEON, Yeonsook CHUNG, Jongsoo KIM, Sooghang IHN
  • Publication number: 20170369440
    Abstract: A new process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile is described. This compound can be used for the production of drugs, such as Fexofenadine.
    Type: Application
    Filed: January 21, 2016
    Publication date: December 28, 2017
    Inventors: Hermut WEHLAN, Kai ROSSEN, Alexander SCHAEFER
  • Publication number: 20170369441
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC1 and/or HDAC2 activity.
    Type: Application
    Filed: September 11, 2017
    Publication date: December 28, 2017
    Inventors: John H. van Duzer, Ralph Mazitschek
  • Publication number: 20170369442
    Abstract: The present invention describes a novel method for preparing 4-cyanopiperidine hydrochloride.
    Type: Application
    Filed: January 13, 2016
    Publication date: December 28, 2017
    Inventors: THOMAS HIMMLER, DIRK BROHM
  • Publication number: 20170369443
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: September 5, 2017
    Publication date: December 28, 2017
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON, Imelda CALDERON
  • Publication number: 20170369444
    Abstract: Compounds of the form in which Q is selected from —COOH—CH?NR12, —W, —CH2NHR13, —CH=0 and —CH(OR17)2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.
    Type: Application
    Filed: March 30, 2015
    Publication date: December 28, 2017
    Inventors: Marc Labelle, Rui Zhang, Cuthbert D. Martyr, Neerja Saraswat, Thomas Boesen
  • Publication number: 20170369445
    Abstract: The instant invention relates to compounds of formula I wherein: R is selected from H, Me or Cl, and R? is selected from: H, NH2, NHCOCH3 NHCOCF3 or NHCOCH2Cl. The invention further provides a process for obtaining the compounds of formula I and their use.
    Type: Application
    Filed: January 14, 2016
    Publication date: December 28, 2017
    Inventors: Núbia Boechat, Frederico Silva Castelo Branco
  • Publication number: 20170369446
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: September 8, 2017
    Publication date: December 28, 2017
    Inventors: William C. Shakespeare, Wei-Sheng Huang, David C. Dalgarno, Xiaotian Zhu, R. Mathew Thomas, Yihan Wang, Jiwei Qi, Rajeswari Sundaramoorthi, Dong Zou, Chester A. Metcalf, III, Tomi K. Sawyer, Jan Antoinette C. Romero
  • Publication number: 20170369447
    Abstract: The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.
    Type: Application
    Filed: September 6, 2017
    Publication date: December 28, 2017
    Inventors: Lyudmyla Chumakova, Andrew Patron, Chad Priest, Donald Karanewsky, Rachel Kimmich, Brant Clayton Boren, Jeffrey Robert Hammaker, Volodymyr Chumakov, Wen Zhao, Alain Noncovich, Jane Ung