Patents Issued in January 25, 2018
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Publication number: 20180022655Abstract: A method for manufacturing a ceramic material includes a step of performing heat treatment in a reducing atmosphere on a ceramic material in which a metallic oxide is diffused in crystal grains, thereby to reduce the metallic oxide to deposit a metallic element at grain boundaries of the ceramic material.Type: ApplicationFiled: December 24, 2015Publication date: January 25, 2018Applicants: SUMITOMO ELECTRIC INDUSTRIES, LTD., KYOTO UNIVERSITYInventors: Masatoshi MAJIMA, Hiromasa TAWARAYAMA, Chihiro HIRAIWA, Takahiro HIGASHINO, Yohei NODA, Naho MIZUHARA, Tetsuya UDA, Donglin HAN
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Publication number: 20180022656Abstract: An aqueous composition is used for repairing and/or sealing of hardened concrete structures, the aqueous composition including colloidal silica and polycarboxylate ether.Type: ApplicationFiled: February 9, 2016Publication date: January 25, 2018Applicant: SIKA TECHNOLOGY AGInventors: Cristina VALVERDE, Luz GRANIZO FERNANDEZ, Ramiro GARCIA
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Publication number: 20180022657Abstract: The present invention is directed to Mycorrhizal seed and in-furrow compositions containing paraffinic oil. The present invention is further directed to methods of improving plant growth by applying Mycorrhizal seed treatment and in-furrow compositions containing a paraffinic oil to a plant, plant propagation material, or an area where a plant will grow.Type: ApplicationFiled: July 21, 2017Publication date: January 25, 2018Inventors: Bala N. Devisetty, Alok Adholeya
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Publication number: 20180022658Abstract: The present invention is directed to Mycorrhizae seed and in-furrow compositions containing soybean oil. The present invention is further directed to methods of improving plant growth by applying Mycorrhizal seed treatment and in-furrow compositions containing soybean oil to a plant, plant propagation material, or an area where a plant will grow.Type: ApplicationFiled: July 21, 2017Publication date: January 25, 2018Inventors: Bala N. Devisetty, Alok Adholeya
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Publication number: 20180022659Abstract: The present invention is directed to Mycorrhizal seed and in-furrow compositions containing polyethylene glycol. The present invention is further directed to methods of improving plant growth by applying Mycorrhizal seed and in-furrow compositions containing polyethylene glycol to a plant, plant propagation material or an area where a plant will grow.Type: ApplicationFiled: July 21, 2017Publication date: January 25, 2018Inventors: Bala N. Devisetty, Alok Adholeya
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Publication number: 20180022660Abstract: The present invention is directed to Mycorrhizal wettable powder formulations containing lactose and sodium lignosulfonate. The present invention is further directed to methods of improving plant growth by applying a Mycorrhizae wettable powder formulation containing lactose and sodium lignosulfonate to a plant or an area where a plant will grow including plant root zones and furrows.Type: ApplicationFiled: July 21, 2017Publication date: January 25, 2018Inventors: Bala N. Devisetty, Alok Adholeya
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Publication number: 20180022661Abstract: Moisture barrier coatings and sealants comprised of mixtures of organic wax and wax soluble polymer dispersed into one or more components of a thermoset polymer which may form a semi-interpenetrating polymer network when the thermoset polymer is subsequently cured on the substrate. The organic wax and wax soluble polymer substantially improve the moisture barrier properties of the thermoset polymer and provides an effective moisture barrier coating that is non-tacky at the cure temperature of the thermoset polymer, without the requirement for a cooling step.Type: ApplicationFiled: July 21, 2017Publication date: January 25, 2018Inventors: Felix Achille, Victor Granquist, A. Jaeton Glover, Alice Hudson
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Publication number: 20180022662Abstract: Reaction products and methods for making and using such reaction products are provided. For example, a reaction product comprising an adduct formed from urea, formaldehyde, and a urease inhibitor is described, which can be provided in various forms. For example, such a reaction product can be in the form of a solid or solution. Such a reaction product can also be combined with one or more additional components, including but not limited to, additional urease inhibitor and/or a nitrogen-based fertilizer composition.Type: ApplicationFiled: July 7, 2017Publication date: January 25, 2018Applicant: Koch Agronomic Services, LLCInventors: Douglas Barr, Ethel Garnier, Kwame Owusu-Adom
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Publication number: 20180022663Abstract: A reactive burning rate accelerator is provided that is configured to be at least partially embedded in a solid energetic material and comprises at least one metallic component and at least one non-metallic component. The reactive burning rate accelerator is configured to ignite and combust to increase the mass burning rate of the solid energetic material. Also provided are solid energetic materials comprising the reactive burning accelerator and methods of manufacturing and using the same.Type: ApplicationFiled: February 3, 2017Publication date: January 25, 2018Inventors: Sarah Isert, Steven Forrest Son, Colin D. Lane, Ibrahim Emre Gunduz
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Publication number: 20180022664Abstract: A process for post synthesis treatment of ZSM-5 catalyst for converting ethylene to liquid fuel products providing substantially improved catalyst life. The treatment comprises either a base treatment, an acid treatment or a two-step treatment where one is with an acid and the other is with a base. The base treatment is provided by a weak sodium hydroxide such as less than 1 Molar concentration. The acid treatment is stronger acid where, for example, a hydrogen chloride solution at greater than 2 Molar concentration is used.Type: ApplicationFiled: July 21, 2016Publication date: January 25, 2018Applicant: PHILLIPS 66 COMPANYInventors: Jianhua Yao, Bruce B. Randolph
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Publication number: 20180022665Abstract: A process for post synthesis treatment of ZSM-5 catalyst for converting ethylene to liquid fuel products providing substantially improved catalyst life. The treatment comprises either a base treatment, an acid treatment or a two-step treatment where one is with an acid and the other is with a base. The base treatment is provided by a weak sodium hydroxide such as less than 1 Molar concentration. The acid treatment is stronger acid where, for example, a hydrogen chloride solution at greater than 2 Molar concentration is used.Type: ApplicationFiled: July 21, 2016Publication date: January 25, 2018Applicant: PHILLIPS 66 COMPANYInventors: Jianhua Yao, Bruce B. Randolph
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Publication number: 20180022666Abstract: A process for post synthesis treatment of ZSM-5 catalyst for converting ethylene to liquid fuel products providing substantially improved catalyst life. The treatment comprises either a base treatment, an acid treatment or a two-step treatment where one is with an acid and the other is with a base. The base treatment is provided by a weak sodium hydroxide such as less than 1 Molar concentration. The acid treatment is stronger acid where, for example, a hydrogen chloride solution at greater than 2 Molar concentration is used.Type: ApplicationFiled: July 21, 2016Publication date: January 25, 2018Applicant: PHILLIPS 66 COMPANYInventors: Jianhua Yao, Bruce B. Randolph
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Publication number: 20180022667Abstract: The invention relates to converting non-aromatic hydrocarbon in the presence of CO2 to produce aromatic hydrocarbon. CO2 methanation using molecular hydrogen produced during the aromatization increases aromatic hydrocarbon yield. The invention also relates to equipment and materials useful in such upgrading, to processes for carrying out such upgrading, and to the use of such processes for, e.g., natural gas upgrading.Type: ApplicationFiled: September 12, 2017Publication date: January 25, 2018Inventors: John S. Buchanan, Paul F. Keusenkothen, David W. Maher, Jaime A. Valencia
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Publication number: 20180022668Abstract: The present subject matter relates generally to methods for treating an organic feed. More specifically, the present subject matter relates to methods for reducing the water content of an organic feed before the organic feed enters a hydrogenation zone, thereby by improving the activity, conversion, and life of the hydrogenation catalyst. The hydrogenation zone product stream is then sent to a phenol recovery zone.Type: ApplicationFiled: September 30, 2017Publication date: January 25, 2018Inventors: Chad A. Williams, Patrick J. Bullen, Clint H. Vericker, Russell C. Schulz, Jose L. Miramontes
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Publication number: 20180022669Abstract: A process for the isomerization of a para-xylene depleted, meta-xylene rich stream under at least partially liquid phase conditions using ZSM-23 with an external surface area of at least 75 m2/g (indicating a small crystallite size), and a SiO2/Al2O3 ratio between 15 and 75 that produces a higher than equilibrium amount of para-xylene, i.e., more than about 24 wt % of para-xylene, based on the total amount of xylenes.Type: ApplicationFiled: October 2, 2017Publication date: January 25, 2018Applicant: ExxonMobil Chemical Patents Inc.Inventors: Brian M. Weiss, Darryl D. Lacy, Scott J. Weigel
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Publication number: 20180022670Abstract: A method for removal of an organic amine from a hydrocarbon stream includes mixing the hydrocarbon stream including the amine with an aqueous inorganic acid in a volumetric ratio of hydrocarbon stream: aqueous inorganic acid of greater than 1.5:1 to 5:1, phase separating a hydrocarbon phase and an aqueous phase, removing the hydrocarbon phase, mixing the aqueous phase with an aqueous alkaline solution, phase separating the aqueous phase and an organic phase, and removing the organic phase. The aqueous inorganic acid has a concentration of greater than or equal to 30 weight percent. The disclosed method results in improved phase separation time during an amine removal process.Type: ApplicationFiled: January 15, 2016Publication date: January 25, 2018Inventors: Bander Bawareth, Shahid Azam, Patel Haresh, Deshmukh V. Rajan, Fahad Mubark Al-Khaldi, Muhamad Rafiq Bn-Hasan Attamim
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Publication number: 20180022671Abstract: A chromia-based fluorination catalyst comprising at least one additional metal selected from zinc, nickel, aluminium and magnesium in which from 0.1 to 8.0% by weight of the catalyst is in the form of one or more crystalline compounds of chromium and/or one or more crystalline compounds of the at least one additional metal. The catalyst can be used in processes for producing a fluorinated hydrocarbon.Type: ApplicationFiled: September 13, 2017Publication date: January 25, 2018Applicant: MEXICHEM AMANCO HOLDING S.A. DE C.V.Inventors: ANDREW P. SHARRATT, JOHN D. SCOTT
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Publication number: 20180022672Abstract: Various compositons, including particularly aerosol compositions, containing fluorinated olefins, including particularly tetra- and penta-fluorpropenes, in a variety of applications are disclosed.Type: ApplicationFiled: September 21, 2017Publication date: January 25, 2018Inventors: Rajiv R. Singh, Hang T. Pham, Ian Shankland
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Publication number: 20180022673Abstract: The present application relates to a process for production of hydrocarbons comprising the steps of converting a feed stream comprising alcohols, ethers or mixtures hereof over a metal-containing zeolite based catalyst, active in dehydrogenation of hydrocarbons, in a conversion step thereby obtaining a conversion effluent, separating said effluent to obtain art aqueous process condensate stream, a liquid hydrocarbon stream and a gaseous stream, removing part of the hydrogen formed in the conversion step, and recycling at least part of the gaseous and/or liquid hydrocarbon stream to the conversion step.Type: ApplicationFiled: January 22, 2016Publication date: January 25, 2018Applicant: HALDOR TOPSØE A/SInventors: Finn JOENSEN, Uffe Vie MENTZEL, Ian MENJON
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Publication number: 20180022674Abstract: The present invention relates to a process for the preparation of ospemifene and pharmaceutically acceptable salts thereof which comprises the step of recycling the undesired E-4-(4-hydroxy-1,2-diphenylbut-1-enyl)phenol to generate an isomeric mixture of Z,E-4-(4-hydroxy-1,2-diphenylbut-1-enyl)phenol.Type: ApplicationFiled: January 6, 2016Publication date: January 25, 2018Inventors: Veerabhadra SWAMY, Kumar Hari BHUSHAN, Shekha Bhaskar BHIRUD, Dilipkumar Jibhau PATIL, Eknath Kundlik KHEMNAR
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Publication number: 20180022675Abstract: A method for producing a thermodynamically more stable clathrate compound including at least one compound selected from the group consisting of 1,1,2,2-tetrakis(4-hydroxyphenyl)ethane, 5-hydroxyisophthalic acid, and 5-nitroisophthalic acid as a host compound and an imidazole compound as a guest compound. The method for producing a clathrate compound includes: a mixing step of mixing a mixed solvent including a protic solvent, at least one compound selected from the group consisting of 1,1,2,2-tetrakis(4-hydroxyphenyl)ethane, 5-hydroxyisophthalic acid and 5-nitroisophthalic acid, and an imidazole compound; and a heating step.Type: ApplicationFiled: January 13, 2016Publication date: January 25, 2018Applicant: NIPPON SODA CO., LTD.Inventors: Kazuo ONO, Eiji HOSHI
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Publication number: 20180022676Abstract: Disclosed is a method of making and using a titania supported palladium catalyst for the single step synthesis of 2-ethylhexanal from a feed of n-butyraldehyde. This titania supported palladium catalyst demonstrates high n-butyraldehyde conversion but also produces 2-ethylhexanal in an appreciable yield with maintained activity between runs. This method provides a single step synthesis of 2-ethylhexanal from n-butyraldehyde with a catalyst that can be regenerated that provides cleaner downstream separations relative to the traditional caustic route.Type: ApplicationFiled: September 29, 2017Publication date: January 25, 2018Applicant: Eastman Chemical CompanyInventors: Venkata Bharat Boppana, Kenneth Wayne Hampton, JR., Zhufang Liu, Charles Edwan Sumner, JR., Gerald Charles Tustin, Guy Ralph Steinmetz, Melissa Page Steffey
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Publication number: 20180022677Abstract: Provided are integrated processes for the conversion of beta propiolactone to acrylic acid. Systems for the production of acrylic acid are also provided.Type: ApplicationFiled: February 12, 2016Publication date: January 25, 2018Applicant: Novorner, Inc.Inventor: Sadesh H. SOOKRAJ
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Publication number: 20180022678Abstract: The invention relates to a method for the catalytic generation of formic acid at an oxygen partial pressure below 1 bar and regeneration of the catalyst used therefor.Type: ApplicationFiled: January 22, 2016Publication date: January 25, 2018Applicant: OXFA GMBHInventor: Hermann Wolf JBACH
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Publication number: 20180022679Abstract: The inventive concepts disclosed and/or claimed herein relate generally to catalysts and, more particularly, but not by way of limitation, to a heterogeneous, metal-free hydrogenation catalyst containing frustrated Lewis pairs. In one non-limiting embodiment, the heterogeneous, metal-free catalyst comprises hexagonal boron nitride (h-BN) having frustrated Lewis pairs therein.Type: ApplicationFiled: August 7, 2017Publication date: January 25, 2018Inventor: Richard G. Blair
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Publication number: 20180022680Abstract: The objective of the present invention is to provide a method for efficiently producing acrylic acid while troubles not only in a waste oil handling after distillation of acrylic acid but also in a purification system of acrylic acid during distillation are reduced. The method for producing acrylic acid according to the present invention is characterized in comprising the step of supplying at least crude acrylic acid and an alcohol solvent to an acrylic acid distillation apparatus to distill acrylic acid, wherein a boiling point of the alcohol solvent is higher than a boiling point of acrylic acid by not lower than 50° C.Type: ApplicationFiled: January 26, 2016Publication date: January 25, 2018Applicant: Nippon Shokubai Co., Ltd.Inventors: Toyofumi SAKAI, Masashi MUKAE, Yasutaka TAKEMOTO
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Publication number: 20180022681Abstract: The present invention relates to a novel process for the preparation of a linear monomer alkyl lactyl lactate by a simple esterification reaction of acid with ester in presence of suitable catalysts or reagents. The present invention further relates to a process for the preparation of poly acid from alkyl lactyl lactate by using suitable catalyst.Type: ApplicationFiled: January 29, 2016Publication date: January 25, 2018Inventors: Yogesh Ramesh Nevare, Susheela Bhaskar Idage, Bhaskar Bhairavnath Idage, Swaminathan Sivaram
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Publication number: 20180022682Abstract: The invention relates to a conversion method that is fed with a diol feedstock that comprises at least 90% by weight of diol and a carboxylic acid feedstock that comprises at least 80% by weight of carboxylic acid. The method comprising at least: An esterification step which is fed with at least the diol feedstock and at least the carboxylic acid feedstock, wherein the carboxylic acid/diol molar ratio at the inlet of the esterification step is between 2 and 6, the esterification step comprises at least one reactive distillation column that has a mixed reaction/separation zone located between two separation zones; and A water elimination step that is fed with distillate from the esterification step that comprises water and producing at least one water effluent.Type: ApplicationFiled: February 17, 2016Publication date: January 25, 2018Applicants: IFP Energies Nouvelles, Compagnie Generale des Etablissements MichelinInventors: Romain RICHARD, Damien LEINEKUGEL LE COCQ, Marc JACQUIN, Margarita DORATO, Nuno PACHECO, Claire RANNOUX
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Publication number: 20180022683Abstract: The present invention relates to a method for producing a substituted alkyl cycloalkanone of formula (I), having the alkylation of a cycloalkanone of formula (II) with an alkene derivative of formula (III) in the presence of a metal oxide, where n is 2 to 20, m is 0 to 10, and R is a functional group.Type: ApplicationFiled: January 13, 2016Publication date: January 25, 2018Applicant: SYMRISE AGInventors: Atia HANAN, Reinhard ECKELT, Angela KOECKRITZ, Johannes PANTEN, Peter ESSER, Oskar KOCH
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Publication number: 20180022684Abstract: The invention relates to a process comprising the process steps of: a) initially charging an ether having from 3 to 30 carbon atoms; b) adding a phosphine ligand and a compound comprising Pd, or adding a comprising Pd and a phosphine ligand; c) feeding in CO; d) heating the reaction mixture, with conversion of the ether; wherein the phosphine ligand is a compound of formula (I) where m and n are each independently 0 or 1; R1, R2, R3, R4 are each independently selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —(C6-C20)-aryl, —(C3-C20)-heteroaryl; at least one of the R1, R2, R3, R4 radicals is a —(C3-C20)-heteroaryl radical; and R1, R2, R3, R4, if they are —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —(C6-C20)-aryl or —(C3-C20)-heteroaryl, may each independently be substituted by one or more substituents selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —O—(C1-C12)-alkyl, —O—(C1-C12)-alkyl-(C6-C20)-aryl, —O—(C3-C12)Type: ApplicationFiled: July 17, 2017Publication date: January 25, 2018Applicant: EVONIK DEGUSSA GMBHInventors: Kaiwu DONG, Ralf JACKSTELL, Helfried NEUMANN, Matthias BELLER, Dirk FRIDAG, Dieter HESS, Katrin Marie DYBALLA, Frank GEILEN, Robert FRANKE
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Publication number: 20180022685Abstract: The invention relates to a process comprising the following process steps: a) introducing an ether having 3 to 30 carbon atoms; b) adding a phosphine ligand and a compound which comprises Pd, or adding a complex comprising Pd and a phosphine ligand; c) adding an alcohol; d) supplying CO; e) heating the reaction mixture, the ether being reacted for form an ester; where the phosphine ligand is a compound of formula (I) where m and n are each independently 0 or 1; R1, R2, R3, R4 are each independently selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —(C6-C20)-aryl, —(C3-C20)-heteroaryl; at least one of the R1, R2, R3, R4 radicals is a —(C3-C20)-heteroaryl radical; and R1, R2, R3, R4, if they are —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —(C6-C20)-aryl or —(C3-C20)-heteroaryl, may each independently be substituted by one or more substituents selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —O—(C1-C12)-alkyl,Type: ApplicationFiled: July 17, 2017Publication date: January 25, 2018Applicant: EVONIK DEGUSSA GMBHInventors: Kaiwu DONG, Ralf JACKSTELL, Helfried NEUMANN, Matthias BELLER, Dirk FRIDAG, Dieter HESS, Katrin Marie DYBALLA, Frank GEILEN, Robert FRANKE
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Publication number: 20180022686Abstract: Process comprising the following process steps: a) introducing an ethylenically unsaturated compound; b) adding a ligand-metal complex comprising Pd and a bidentate phosphine ligand, or adding a bidentate phosphine ligand and a compound which comprises Pd; c) adding an alcohol; d) supplying CO; e) heating the reaction mixture, the ethylenically unsaturated compound being reacted to form an ester, where the reaction mixture is admixed with less than 0.1 mol %, based on the amount of substance of the ethylenically unsaturated compound, of Brønsted acids having an acid strength of pKa ?3, characterized in that the phosphine ligand is substituted on at least one phosphorus atom by at least one heteroaryl radical.Type: ApplicationFiled: July 17, 2017Publication date: January 25, 2018Applicant: EVONIK DEGUSSA GMBHInventors: Xiangjie FANG, Kaiwu DONG, Helfried NEUMANN, Ralf JACKSTELL, Matthias BELLER, Dirk FRIDAG, Dieter HESS, Katrin Marie DYBALLA, Frank GEILEN, Robert FRANKE
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Publication number: 20180022687Abstract: The invention relates to a method comprising the method steps of: a) initially charging a diene having two conjugated double bonds; b) adding a phosphine ligand and a catalyst precursor selected from palladium dichloride, palladium dibromide, palladium diiodide, palladium(II) acetylacetonate, palladium(II) acetate, bis(dibenzylideneacetone)palladium, bis(acetonitrile)dichloropalladium(II), palladium (cinnamyl) dichloride; c) adding an alcohol; d) feeding in CO; d) heating the reaction mixture, with conversion of the diene to a di- or tricarboxylic ester; wherein the phosphine ligand is a compound according to formula (I) where R1, R2, R3, R4 are selected from —(C1-C12)-alkyl, —(C6-C20)-aryl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —(C3-C20)-heteroaryl; R5, R6 are selected from —H, —(C1-C12)-alkyl, —(C6-C20)-aryl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —(C3-C20)-heteroaryl; and R1, R2, R3, R4, R5, R6, in the case that these are —(C1-C12)-alkyl, —(C6-C20)-aryl, —(C3-C12)-cycloalkyType: ApplicationFiled: July 17, 2017Publication date: January 25, 2018Applicant: EVONIK DEGUSSA GMBHInventors: Kaiwu DONG, Ralf JACKSTELL, Matthias BELLER, Dirk FRIDAG, Dieter HESS, Katrin Marie DYBALLA, Frank GEILEN, Robert FRANKE
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Publication number: 20180022688Abstract: The invention relates to new compounds as well as a separation method, a synthetic method and use thereof. It is demonstrated by an assay on activity that the compound has an activity of inhibiting an HMG-CoA reductase. In addition, the invention also relates to a derivative of the compound.Type: ApplicationFiled: January 27, 2016Publication date: January 25, 2018Inventors: Zhenwen Duan, Shuren Guo, Xuemei Li
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Publication number: 20180022689Abstract: Provided are compounds of the following: wherein R1 is a saturated or unsaturated cyclic hydrocarbon optionally substituted with an alkyl and/or an OXO-ester, and R2 is a C4 to C14 hydrocarbyl, preferably the residue of a C4 to C14 OXO-alcohol. Also provided are processes for making the compounds and plasticized polymer compositions containing said compounds.Type: ApplicationFiled: October 2, 2017Publication date: January 25, 2018Inventors: Jihad M. Dakka, Christine A. Costello, Edmund J. Mozeleski, Stephen Zushma, Diana S. Smirnova, Catherine A. Faler, Victor DeFlorio
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Publication number: 20180022690Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.Type: ApplicationFiled: February 11, 2016Publication date: January 25, 2018Inventors: Benjamin MARTIN, Francesca MANDRELLI, Francesco VENTURONI
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Publication number: 20180022691Abstract: Ethylenediamine (EDA) compositions and methods for making the EDA that is suitable for use in thin-film semiconductor processing applications, are disclosed. The EDA is purified to remove water and trace metals. Water levels below about 50 ppm by weight are achieved by passing liquid through 3A type molecular sieve in a packed bed. Metallic impurities are removed by distillation and the resulting product is packaged in specially dried and optionally pre-conditioned containers.Type: ApplicationFiled: July 13, 2017Publication date: January 25, 2018Applicant: Versum Materials US, LLCInventors: Hareesh Thridandam, Stuart H. Dimock, Steven Gerard Mayorga, Ronald Martin Pearlstein
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Publication number: 20180022692Abstract: Provided is a method for producing 2-aminoethyl methacrylate hydrochloride that, according to one embodiment, includes a step (A) for reacting a ketimine compound of 2-aminoethyl methacrylate with water and hydrogen chloride and obtaining a mixture containing 2-aminoethyl methacrylate hydrochloride, wherein in the step (A), the ratio of the total amount of hydrogen chloride to the total amount of ketimine compound of 2-aminoethyl methacrylate is 1.0-1.5 expressed in terms of equivalents, and the ratio of the total amount of water to the total amount of ketimine compound of 2-aminoethyl methacrylate is 1.0-2.0 expressed in terms of equivalents.Type: ApplicationFiled: January 26, 2016Publication date: January 25, 2018Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.Inventors: Yuri IIDA, Masaki TAKEMOTO, Hideyuki SATO
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Publication number: 20180022693Abstract: The present invention describes compounds and uses thereof in applications relating to absorption of electromagnetic energy. Preferred compounds are double bond-containing compounds capable of absorbing electromagnetic radiation energy and having improved properties.Type: ApplicationFiled: December 23, 2016Publication date: January 25, 2018Applicant: Commonwealth Scientific and Industrial Research OrganisationInventors: Mark York, John Ryan
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Publication number: 20180022694Abstract: The present disclosure relates to the preparation of a compound of formula (I) comprising an —SO2F function, R—SO2F, by reacting a compound of formula (II), R?—SO2X, with a fluorinating agent, the process carried out in the liquid phase in the presence of hydrofluoric acid using an antimony-based fluorination catalyst, wherein R, R?, and X are described herein.Type: ApplicationFiled: August 14, 2017Publication date: January 25, 2018Inventor: François METZ
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Publication number: 20180022695Abstract: Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. Moreover, provided herein are methods of making or manufacturing compounds disclosed herein, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or Co-crystals and prodrugs thereof.Type: ApplicationFiled: September 29, 2017Publication date: January 25, 2018Inventors: Jorge E. Gomez-Galeno, Scott J. Hecker, Qun Dang, Mali Venkat Reddy, Zhili Sun, Matthew P. Grote, Thanh Huu Nguyen, Robert Huerta Lemus, Haiqing Li
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Publication number: 20180022696Abstract: The present invention relates to novel N-acyl-diarysulfonamides acting as inhibitors of bacterial aminoacyl-tRNA synthetase. These can be used as medicines or as constituent of medicines for the treatment of bacterial infections.Type: ApplicationFiled: February 11, 2016Publication date: January 25, 2018Inventors: Aigars JIRGENSONS, Einars LOZA, Michael CHARLTON, Paul William FINN, Lluis RIBAS DE POUPLANA, Adelaide SAINT-LÉGER
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Publication number: 20180022697Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.Type: ApplicationFiled: February 1, 2016Publication date: January 25, 2018Inventors: Scott D. Larsen, Akira Abe, Liming Shu, Michael William Wilson, Richard F. Keep, Duxin Sun, James A. Shayman
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Publication number: 20180022698Abstract: Methods of treatment useful in the inducement or maintenance of anesthesia in a subject are provided. The methods comprise administering to a subject in need of anesthesia a compound disclosed herein. Also provided are novel compounds having anesthetic effects, pharmaceutical compositions comprising the compounds, and packaged pharmaceuticals. Computer modeling of the compounds demonstrates favorable interactions with the GABA receptor type A. In addition, the compounds display reversible anesthetic effects in an animal model, with dose-response curves similar to those of known general anesthetics. GABA receptor-mediated effects are also demonstrated in a hippocampal brain slice preparation.Type: ApplicationFiled: October 16, 2015Publication date: January 25, 2018Inventors: Edward John BERTACCINI, Margaret Frances DAVIES
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Publication number: 20180022699Abstract: The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R1, and Z1-Z5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.Type: ApplicationFiled: August 4, 2017Publication date: January 25, 2018Inventors: Donald J. Kyle, Chiyou Ni, Laykea Tafesse, Jiangchao Yao
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Publication number: 20180022700Abstract: Disclosed are a compound as shown by the following formula 1, and a pharmaceutically acceptable salt, an ester, a hydrate and an organic solvate thereof. In the formula (1), the groups R1 to R17 are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, C1-C8 alkyl, C1-C8 alkoxy, carbonyl, hydroxyl, amino, azido, carboxyl and C1-C8 alkylsulfinyl, respectively; and X is a carbon or nitrogen atom; Y is selected from the following groups: a single bond, C1-C8 alkylene, C6-C20 arylene and C4-C20 heteroarylene; and n is an integer from 5 to 20. Also provided in the present invention are a pharmaceutical composition containing the compound, and use thereof in the field of tumor therapy.Type: ApplicationFiled: January 25, 2016Publication date: January 25, 2018Inventor: Ruiqiong RAN
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Publication number: 20180022701Abstract: The present invention relates to compounds according to Formula I (Formula I), and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.Type: ApplicationFiled: July 12, 2017Publication date: January 25, 2018Inventors: Kenneth J. Barr, Corey E. Bienstock, John K. Maclean, Hongjun Zhang, Richard T. Beresis, Dongshan Zhang, Neville J. Anthony, Blair T. Lapointe, Yuan Tian
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Publication number: 20180022702Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC1 and/or HDAC2 activity.Type: ApplicationFiled: September 29, 2017Publication date: January 25, 2018Inventors: John H. van Duzer, Ralph Mazitschek
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Publication number: 20180022703Abstract: An herbicidal composition containing (a) a pyridine or pyrimidine carboxylic acid component and (b) a second cereal or rice herbicide component provides synergistic control of selected weeds.Type: ApplicationFiled: August 8, 2017Publication date: January 25, 2018Inventors: Norbert M. Satchivi, Paul R. Schmitzer, Carla N. Yerkes, Terry R. Wright
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Publication number: 20180022704Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.Type: ApplicationFiled: October 4, 2017Publication date: January 25, 2018Applicant: Janssen Pharmaceutica NVInventors: Diego Fernando Domenico BROGGINI, Vit LELLEK, Susanne LOCHNER, Neelakandha S. MANI, Adrian MAURER, Daniel J. PIPPEL, Lana K. YOUNG