Abstract: An auto-injector device for administering a liquid pharmaceutical composition, in which an end-user can select between doses that the device is capable of delivering. The end-user choices that translate into the selected doses can be based on end-user perceived severity of symptoms, end-user weight and other such factors. In some embodiments the auto-injector is configured to administer the one chosen dose only. In other embodiments, the auto-injector can deliver second and subsequent doses up to full dose of the pharmaceutical composition disposed in the injector. The auto-injector can provide visual, audio, and tactile feedback, alone or in combination, to the user to indicate the dose selected, instructions for use, and when the dose has been administered.

Abstract: An auto-injector device for administering a liquid pharmaceutical composition, in which an end-user can select between doses that the device is capable of delivering. The end-user choices that translate into the selected doses can be based on end-user perceived severity of symptoms, end-user weight and other such factors. In some embodiments the auto-injector is configured to administer the one chosen dose only. In other embodiments, the auto-injector can deliver second and subsequent doses up to full dose of the pharmaceutical composition disposed in the injector. The auto-injector can provide visual, audio, and tactile feedback, alone or in combination, to the user to indicate the dose selected, instructions for use, and when the dose has been administered.

Abstract: Auto-injector for administering a dose of a liquid medicament includes a housing to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), the housing having a distal end (D) and a proximal end (P) with an orifice to apply against an injection site. A spring means, upon activation, can push the needle from inside the housing through the orifice and past the proximal end (P), operate the syringe to supply the dose of medicament (M), and retract the syringe with the needle after delivering the medicament (M). An activating means can lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.

Abstract: An intradermal injection device comprises a housing, a foot with an opening for passage of a needle; a reservoir movably mounted in the housing, and having a hollow space for holding a fluid; a hollow needle movably mounted in the housing and having a first end for penetrating the subject's skin and a second end for penetrating the reservoir, a plunger movably mounted in the housing for moving the needle through the opening for penetrating the subject's skin, and for pressing the fluid out of the reservoir. The reservoir is frictionally mounted inside the housing by first friction means, and the plunger is frictionally mounted to the reservoir by second friction means. The force to overcome the second friction is larger than the force to overcome the first friction.

Abstract: In one aspect, a safety pen needle assembly is provided which includes a hub having an open proximal end, a needle fixed to the hub having a distal end, and a shield moveably mounted to the hub so as to be movable relative to the hub to selectively cover the distal end of the needle. An interface is defined between the shield and the hub which is sufficiently sealed so as to define a sterility barrier which prevents ingress of contaminants through the interface. At least one sterility barrier is mounted directly to, and across, an open proximal end of the hub and an open distal end of the shield.

Abstract: The present invention relates to a device for removing delivery member shields which are intended to cover and protect delivery members, said device comprising a remover body arranged to accommodate a delivery member in its interior. The invention is characterized in that the remover body comprises at least two sets of gripping members extending into its interior and wherein each set of gripping members is configured for gripping a certain type of delivery member shield.

Abstract: A retractable needle device attachable to the front of a fluid collection or infusion device such as a syringe, the retractable needle device comprising a housing having an engagement member, a slide support surface, a retraction cavity and a first pinch surface; a needle; a needle alignment member comprising a needle tube and a second pinch surface; and a needle retraction mechanism positioned within the needle tube and configured to bias the needle rearwardly; wherein the first and second pinch surfaces are configured so that a pinching force applied to them will cause relative lateral movement between the housing and needle alignment member. This translational movement from an injection position, wherein the needle is aligned with the syringe connector, to a retraction position, wherein the needle is aligned with the retraction cavity, allows the needle retraction mechanism to force the needle into the retraction cavity.

Abstract: The present invention discloses a disposable safety self-destruction insulin needle. The invention uses a sleeve-connected linkage structure and realizes an instant reset of the safety sleeve by means of the spring located in the middle axis so as to ensure that the needle tube is not exposed and preferably realizes a tilting and deflection of the self-destruction pressure base due to a plurality of flexible plates unevenly distributed on the inner wall in the needle base so as to finally ensure that the insulin needle cannot be used a second time, in so doing the safety self-destruction operation of the insulin needle is realized.

Abstract: An apparatus provides feedback regarding the material in which tip of the apparatus is located as the tip is advanced into matter of varying resistances. The apparatus responds to a change in pressure, force, or other parameter such that when the tip reaches matter of a certain resistance, a change in the parameter is sensed. The apparatus provides a driving force to a penetrating medical device, such as a needle, when the apparatus tip encounters material of high resistance. When the apparatus tip encounters a low resistance material, no further driving force is applied to the apparatus. An inner core may be advanced into the low resistance material for deployment of a gas or a liquid as desired.

Abstract: A needle system for penetrating to or passing thought an object or an organ comprising a semiconductor die, one or more needles, wherein the needles slide over the plane of the die, one or more actuators that move the needles relative to the die plane, and one or more actuator drivers controlled by a controller wherein the controller instruct the needle to penetrate into or to pass through and/or retract from the object or organ. The needle system is used for drug delivery or blood extraction or blood analysis or glucose measurements or blood measurements or nerve system stimulus treatment or hair removal or skin lesions removal.

Abstract: A system for use in filling one or more reservoirs. The system includes a fill station including a fill station base, a fill station cover hingably attached to the fill station base, and a filling aperture attached to the fill station cover, wherein the fill station may be opened to accommodate the one or more reservoirs. The system also includes a vial having an interior volume for containing a fluidic medium, the vial configured to removably attach to the filling aperture, and a plunger located within the vial, the plunger advancable within the vial to reduce the interior volume.

Abstract: A connector mountable to a syringe barrel has a proximal barrel-engaging portion, a distal luer fitment portion, and a fluid aperture therethrough. The barrel-engaging portion of the connector includes an axial ledge configured to abut the axial distal edge of a glass syringe barrel. The connector facilitates mounting a luer assembly to the barrel. The luer assembly may be a tip cap having a complementary luer fitment for connection to the luer fitment portion of the connector. The luer assembly may be a luer needle assembly having a complementary luer fitment for connection to the luer fitment portion of the connector. The connector and syringe may further include an immobile, compressible needle seal. The needle seal is adjacent to or engageable with the barrel-engaging portion of the connector. The syringe may be configured with a plunger capable of engaging a retractable needle.

Abstract: A metered dose inhaler (“MDI”) applicator is disclosed that includes a carrier, a housing, an adjuster and a lever. The carrier defines an aperture configured to receive a boot of a MDI. The housing is configured to be assembled with the carrier and to move in a vertical direction within the MID applicator relative to the carrier. The adjuster is configured to move between a locked position and an unlocked position, wherein when the adjuster is in the locked position, the adjuster is configured to prevent the carrier and the housing from moving in one or more directions relative to one another. The lever is pivotally connected to the housing and is configured to transfer a force applied to the lever to a canister of the MDI and to actuate the MDI to dispense an aerosolized medicine.

Abstract: A seal for a gas treatment hood assembly is disclosed. The hood assembly is placeable over a user's head for treating a user with a gas such as oxygen. The assembly may have a neck ring around a user's neck with an elastomeric, tubular neck seal with one end of the neck seal connected to the neck ring and the other end configured to fit around the user's neck. The neck seal may have a double sealing element construction and may also have variable thickness along a sidewall for enhanced structural properties and improved patient comfort. The seal and hood assembly may be used in providing oxygen to a patient in a hyperbaric chamber.

Abstract: An improvement to a breathing therapy machine to detect and rate occurrences of periodic breathing and to alter the therapy delivered to a user of the device based on the rating.

Abstract: An interface appliance is configured to deliver a flow of fluid to the airway of a subject. The generation of the flow of fluid may be controlled to provide a therapeutic benefit to the subject. The interface appliance is configured to carry one or more sensors (24) configured to detect one or more parameters related to the flow of fluid on the subject. The one or more parameters may then be used to control the generation and/or delivery of the flow of fluid.

Abstract: The invention provides a catheter (1) which is movable between an un-expanded and an expanded configuration by use of an advancing mechanism (20). The advancing mechanism facilitates safe and non-contaminated use of the catheter.

Abstract: A steering control apparatus includes a first wire and a second wire extending from a distal end of a catheter to a steering assembly. The steering assembly includes a steering knob disposed at an exterior of the handle, a cylindrical steering shaft projecting from the steering knob and into the interior of the handle, a first cylindrical drum disposed within the handle and connected to the first wire, and a second cylindrical drum within the handle and connected to the second wire. The first drum is configured to engage the steering shaft to produce tension on the first wire. The first drum is coaxial with the steering shaft. The second drum is configured to engage the steering shaft to produce tension on the second wire. The second drum is coaxial with the steering shaft and axially adjacent to the first drum.

Abstract: A holding device for elongated instruments can include a channel for receiving therein an intermediate portion of an elongated instrument. The holding device can include a lock that includes a seat against which the elongated instrument can rest and a resiliently deformable retention arm that is movable relative to the seat. The lock, when in the securing state, can retain within the channel the intermediate portion of the elongated instrument to prevent the intermediate portion from one or more of translating or rotating relative to the device.

Abstract: A sheath introducer system including a sheath introducer defining a lumen therethrough and having a proximal valve housing in fluid communication with a distal tubular sheath, wherein a proximal end of the valve housing defines a proximal opening of the lumen of the sheath introducer. A gasket seated within the valve housing has a first surface, a second surface and an outer periphery extending between the first and second surfaces. A first slit is formed into the first surface having an inner surface defining a first gap. A second slit formed into the second surface having an inner surface defining a second gap. A notch extends into the first gap of the first slit forming a bump on the inner surface of the first slit, wherein the second slit intersects the first slit at the notch such that the notch prevents the first and second slits from being in fluid communication.

Abstract: A control system for an arterial catheter operable to selectively impede blood flow includes a processor and a storage medium accessible to the processor that bears instructions which when executed by the processor cause the processor to execute logic including receiving a first signal representing a physical parameter associated with a patient in whom the catheter is disposed, receiving a second signal representative of time, and causing inflation of a first balloon on the catheter to impede blood flow in the first artery. Based at least in part on the first signal satisfying a first condition, the instructions include causing deflation of the first balloon. Based at least in part on the second signal indicating elapse of a predetermined time period, the instructions include causing deflation of the first balloon regardless of whether the first signal satisfies the first condition.

Abstract: A balloon catheter can evenly transmit a pushing force applied to a reinforcing member to an outer shaft and an inner shaft by fixing the distal end of the reinforcing member to an adhesion part of the outer shaft and the inner shaft. In a balloon catheter, the distal end of a reinforcing member is fixed by an adhesion part of an outer shaft and an inner shaft. Thus, a pushing force of an operator is evenly transmitted to the outer shaft and the inner shaft from the distal end of the reinforcing member through the adhesion part, reducing a relative displacement of the outer shaft and the inner shaft. Moreover, the adhesion part can reduce the detachment of the distal end of the reinforcing member from the outer shaft or the inner shaft.

Abstract: The invention relates to an angioplasty device for treating stenoses or occlusions that facilitates the diagnosis and visualization of the stenosis and the treatment control having a duct dedicated to the injection of the contrast product.

Abstract: A magnetic article with a corrosion resistant barrier formed from a poly (tetrafluoro-p-xylene) conformal coating or from a parylene conformal coating having a melting point of at least about 430° C. and a moisture vapor transmission less than about 0.5 g-mm/m2/day at 90% RH and 37° C., the conformal coating being covered with a polysulfone thermoplastic overlayer.

Abstract: The invention provides a stoma-creating apparatus for creating a stoma in a subject. The apparatus comprises first and second members, and one or more dilation means provided on the first and/or second member. In use, upon respective movement of the first and second members, the stoma-creating apparatus is arranged to move between a first closed configuration in which the one or more dilation means is substantially closed, and a second open configuration in which the one or more dilation means is substantially dilated, thereby creating a stoma in the subject. The invention is particularly concerned with creating stomas which hold a tracheostomy tube in position on the trachea of a patient undergoing a tracheostomy, or for securing a valve or other medical device in position adjacent a patient's pneumothorax.

Abstract: In some embodiments, a medical device for recanalizing a vessel having a blockage and restoring blood flow through an obstructed blood vessel includes an expandable member coupled to a core wire and a hypotube that are movable relative to each other to manipulate the expandable member between various configurations. The expandable member having a capture structure in an expanded configuration. The expandable member can include multiple interstices formed by woven mesh filaments or braided strands through which the material blocking the vessel can pass. The capture structure can include a shape on its external surface that facilitates dislodgement and capture of the material within capture spaces created by the expandable member. Some embodiments include a capture sack or cap for capturing material and preventing material from migrating down stream of the blockage. Superoxygenated blood can be infused distal to the blockage to minimize loss of function during an ischemic event.

Abstract: A microneedle array includes a microneedle unit that includes microneedles; and a microneedle unit support member that includes an opening, guides both ends of the microneedle unit through inclined grooves, and arranges tips of the microneedles so as to project through the opening in an inclined manner.

Abstract: A male luer medical connector includes a needle having a distal portion with a hole opening and contained in the cavity of a resilient seal. The needle has, apart from its distal portion, an additional hole. The seal and needle are shaped so that when the connector is connected, the compressed seal forms with the needle, immediately upstream of the upper level of the additional hole, a sealed cavity for receiving by way of passage in the additional hole a part of the fluid contained in the needle; and when the seal is released the cavity contains fluid when the lateral hole opening into the needle is sealed, and the portions of the seal, downstream and upstream of the cavity respectively, as well as the additional hole, are shaped so the downstream portion closes a lateral hole while the same cavity continues to discharge the fluid into the needle.

Abstract: A injection site information cap includes a housing, a cover portion, an engagement portion configured to couple to and cover an injection port of an injection site, and at least one information element on the cover portion that is positioned to be automatically sensed by at least one sensor of the injection site when the engagement portion is coupled to or is being coupled to the medication injection port. Related apparatus, systems, and techniques are also described.

Abstract: A method and apparatus for iontophoretically administering an anesthetic medicament and simultaneously providing electroanesthesia to a patient is provided. The apparatus comprises a generator operable to produce an electrical current comprised of a direct current superimposed with either an alternating current or a pulsed direct current. A conductive mask is configured to cover the anesthetic medicament applied to a treatment area on the skin of the patient, wherein the conductive mask includes an electrical contact connectable to the generator for receiving the electrical current such that the conductive mask functions as an electrode. One or more additional electrodes are applied to the skin of the patient, wherein each of the additional electrodes is connectable to the generator for receiving the electrical current. At least one of the additional electrodes may comprise a conductive applicator for a cosmetic treatment device.

Abstract: The present invention involves a method and a system for using electrical stimulation and/or chemical stimulation to treat an affective disorder, such as depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.

Abstract: A magnet is completely encased within a body of a biocompatible implant. The body of the biocompatible implant is formed so as to allow for removal of the magnet after implantation in a recipient. The body includes a portion that is at least partially separable from the remainder of the body, either by application of a removing agent or a tool. The magnet can be removed and replaced. Thereafter, the body can be sealed or the magnet can be left exposed.

Abstract: Disclosed herein are current output architectures for implantable stimulator devices. Current source and sink circuitry is divided into a plurality of stages, each of which is capable via an associated switch bank of sourcing or sinking an amount of current to or from any one of the electrodes of the device. The current source circuitry is distinct from the current sink circuitry, and the two share no common circuit nodes prior to connection to the electrodes. In other words, the current source circuitry and the current sink circuitry do not share a common node other than the electrodes. Each stage is preferably formed of a current mirror for receiving a reference current and outputting a scaled version of current to that stage's switch bank. The scalar at each stage can be set by wiring a desired number of output transistors in parallel.

Abstract: A method of modifying cardiac tissue behavior, comprising applying a therapeutically effective electric field having an effect of modifying protein activation levels of at least one protein, and repeatedly applying the field at time intervals timed to increase the activation levels of the at least one protein beyond an activation level achieved by natural and/or paced excitation of the muscle without the application, to an extent about at least as high as a decay of the activation between applications of the field.

Abstract: A catheter may include electrodes for transvascular nerve stimulation. The electrodes may be positioned within lumens of the catheter and aligned with apertures in the outer wall of the catheter. The electrodes may produce focused electrical fields for stimulation of one or more nerves. In one embodiment, the catheter may include a set of proximal electrodes and a set of distal electrodes, and the proximal electrodes may stimulate a patient's left phrenic nerve and the distal electrodes may stimulate a patient's right phrenic nerve.

Abstract: A system and method for promoting immunity of animals or human, which comprises an energy wave generator has an energy wave's frequency control mode. The energy wave's frequency control mode includes multiple controls for acting the energy wave generator to generate and emit energy waves each with a corresponding energy density. The energy density is calculated by a corresponding base frequency, a sweep bandwidth of the corresponding base frequency, an emission rate and a total time of emission in a duty cycle, so that the energy waves with the corresponding energy densities effecting on the body of animals or human to promote immunity of animals or human.

Abstract: An artificial retinal prosthesis system comprises an extraocular optical device and an intraocular retina chip. The extraocular optical device receives an external image, converts it into an optical pulse signal, and generates light energy. The intraocular retina chip receives the optical pulse signal from the extraocular optical device and produces an electric simulation signal. The intraocular retina chip includes a solar cell module receiving and converting the light energy into electric energy as a power source of the intraocular retina chip. The artificial retinal prosthesis system uses an optical modulation method to convert an image signal into an optical pulse signal, transmits the optical pulse signal into the eyeball, and decodes the optical pulse signal intraocularly. Thereby, the signal light intensity is improved without affect the contrast ratio.

Abstract: The present invention is an improved hermetic package for a retinal prosthesis implanted in the human body. The retinal prosthesis includes a flexible circuit electrode array suitable to stimulate the retina while connected to a hermetic package on the outside of the eye, the hermetic package including a cover and a base where the cover is bonded to the base such that the cover and base form the hermetic package.

Abstract: Neurostimulator devices are described comprising: a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the one or more sensors and performing a machine learning method implementing a Gaussian Process Optimization on the at least one complex stimulation pattern. Methods of use are also described.

Abstract: A pacing mode is provided, in one embodiment, that permits missed or skipped ventricular beats. The mode monitors a full cardiac cycle (A-A interval) for the presence of intrinsic ventricular activity. If ventricular activity is present, a flag is set that is valid for the next cardiac cycle. At the beginning of the next cardiac cycle, the device determines if the flag is present. So long as the flag is present, the device will not deliver a ventricular pacing pulse in that cycle, even if there is no intrinsic ventricular activity. If there is no flag present at the start of a given cardiac cycle, a ventricular pacing pulse is delivered and this ventricular activity sets a flag for the subsequent cardiac cycle.

Abstract: A system and method for controlling non-paresthesia stimulation of neural tissue of a patient. The method delivers a non-paresthesia stimulation waveform, senses sensory action potential (SAP) signals from the neural tissue of interest, and analyzes the SAP signals to obtain SAP activity data for at least one of an SAP C-fiber component or an SAP A-delta fiber component. The method determines whether the SAP activity data satisfies a criteria of interest and adjusts at least one of the therapy parameters to change the non-paresthesia stimulation waveform when the SAP activity data does not satisfy the criteria of interest.

Abstract: A method of visualizing a sensation experienced by a patient is disclosed. A graphical user interface is provided. The graphical user interface is configured to receive an input from a user and display a visual output to the user. A virtual control mechanism is displayed on the graphical user interface. One or more engagements of the virtual control mechanism are detected through the graphical user interface. In response to the engagement of the virtual control mechanism, a sensation map history is displayed on the graphical user interface. The sensation map history graphically depicts a migration of a sensation map over time on a virtual human body model.

Abstract: An external control device for use with a neurostimulation system having a plurality of electrodes capable of conveying an electrical stimulation field into tissue in which the electrodes are implanted is provided. The external control device comprises a user interface having one or more control elements, a processor configured for generating stimulation parameters designed to modify the electrical stimulation field relative to one or more neurostimulation lead carrying the electrodes. The external control device further comprises output circuitry configured for transmitting the stimulation parameters to the neurostimulation system.

Abstract: A connector assembly, and its method of assembly, for use in a medical device for connecting an IPG to a connector assembly for connecting the IPG to a relatively large plurality of electrodes that can support 24 or more stimulation channels for stimulating one or more stimulation regions of a patient. Also the IPG and the stimulation system and the stimulation therapy utilizing the connector assembly.

Abstract: A hermetically sealed filtered feedthrough assembly for an active implantable medical device includes an electrically conductive ferrule hermetically sealed by a first braze to an insulator. A conductor is hermetically sealed to and disposed through the insulator. A filter capacitor has an active electrode plate and a ground electrode plate which are disposed within and supported by a capacitor dielectric in an interleaved, partially overlapping relationship. A first passageway is disposed through the capacitor dielectric having a capacitor internal metallization which is connected to the active electrode plate. A capacitor external metallization electrically connects to the ground electrode plate. An oxide-resistant metal addition includes a conductive core with a conductive cladding of a different material. A first electrical connection is between the oxide-resistant metal addition and the capacitor external metallization.

Abstract: A powered case is provided that includes a case, configured to hold an electroactive medical device with an integrated battery; an energizing system, configured to provide electric energy; and an energy transfer system, configured to receive energy from the energizing system; and to transfer the received energy to the integrated battery of the electroactive medical device. Further, a medical device system is provided that can include an electroactive medical device, including an integrated battery; and a powered case, including a case, configured to hold the electroactive medical device with the integrated battery; an energizing system, configured to provide electric energy; and an energy transfer system, configured to receive energy from the energizing system; and to transfer the received energy to the integrated battery of the electroactive medical device.

Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.

Abstract: A device used for relieving pain is disclosed herein. The device can include a base comprising a number of mounting surfaces. The device can also include a number of magnets disposed on the mounting surfaces, where each magnet includes a first end and a second end, where the first end has a first polarity, where the second end has a second polarity, and where the first polarity attracts the second polarity to create a magnetic field, and where the magnets create a number of magnetic fields that intersect at a target area.

Abstract: The inventive technique includes a system, method and device for treating a patient. The device includes a magnetic device having a core created by a binder process having a relatively low temperature. The device further includes a conductor in electrical communication with the core.

Abstract: According to an embodiment of the present application, there is provided a medical apparatus, including: a light source unit configured to be capable of emitting light including at least natural emission light, the light being guided into an optical probe; a first detecting unit configured to detect an intensity of light exiting from the light source unit; and a calculation unit configured to calculate to approximate to a non-linear function based on an intensity of light detected by the first detecting unit for calibration of the optical probe.