Abstract: Certain exemplary embodiments can sterilize a surface via a system comprising a plurality of ultraviolet emitting light sources. The system can comprise a set of rollers constructed to feed a substantially planar item through the system such that the surface is exposed to ultraviolet light from the plurality of ultraviolet emitting light sources.

Abstract: A sanitizer includes a shell defining first and second chamber portions, and having an opening into the first portion. A cover has a closed position over the opening for preventing access to the chamber, and an open position for permitting access to the chamber. A tray is moveable between an access position in the first portion, for placement and retrieval of an article within the tray, and a sanitizing position in the second portion, for exposing the article to sanitizing electromagnetic radiation from an emitter mounted in the second portion. A controller controls an actuator coupled to the tray to move the tray to the sanitizing position when the cover is closed, and to return the tray to the access position when a return condition is satisfied. A radiation barrier is configured to substantially prevent radiation from reaching the opening when the tray is in the access position.

Abstract: Multisource LED systems for providing high intensity narrow spectrum light are provided. In one example embodiment, a lighting system includes one or more first light sources configured to emit high intensity narrow spectrum (HINS) light. The lighting system can include one or more second light sources configured to emit non-HINS light. The system can include a power circuit configured to provide power to the one or more first light sources and the one or more second light sources.

Abstract: A system capable of detecting and/or sterilizing surface(s) of an object using ultraviolet radiation is provided. The system can include a disinfection chamber and/or handheld ultraviolet unit, which includes ultraviolet sources for inducing fluorescence in a contaminant and/or sterilizing a surface of an object. The object can comprise a protective suit, which is worn by a user and also can include ultraviolet sources for disinfecting air prior to the air entering the protective suit. The system can be implemented as a multi-tiered system for protecting the user and others from exposure to the contaminant and sterilizing the protective suit after exposure to an environment including the contaminant.

Abstract: A diffusive illuminator is provided. The diffusive illuminator includes a set of light sources and a light guiding structure including a plurality of layers. At least some of the layers can be formed of a fluoropolymer and at least one layer can be formed of a transparent fluid. The light guiding structure also includes an emission surface through which diffused light exits. The light guiding structure can further include diffusive elements associated with at least one of the plurality of layers. Each diffusive element can diffuse the light to within forty percent of Lambertian distribution. The diffusive elements can be arranged based on a desired uniformity of the diffused light at a target distance corresponding to a surface to be illuminated. The diffusive illuminator can emit ultraviolet light, and can be implemented as part of a disinfection system.

Abstract: A plasma generating system capable of generating a cold plasma. The plasma generating includes two electrodes, a DC voltage source capable of applying a constant DC voltage between the two electrodes, an insulator located in proximity of the two electrodes, and a gas filling a gap between the two electrodes, wherein cold plasma in the form of series of repetitive streamer breakdowns of the gas is generated, in response to the constant DC voltage applied between the two electrodes. A method of producing and storing a sterilizing gas. The method includes providing a flow of a gas into a chamber, generating cold plasma through repetitive streamer breakdowns of the gas in response to an applied DC voltage, resulting in the gas becoming a sterilizing gas. A method of sterilizing an object. The method includes exposing an object to be sterilized to the sterilizing gas for a period of time.

Abstract: A bacteria removing water generation device is provided. The device includes a hypochlorous acid containing water generating part generating water containing hypochlorous acid by electrolyzing tap water; a sterilizing metal ionic water generating part including electrodes, sterilizing metal ion being eluted from the electrodes into the tap water by electrolyzing tap water; a water discharge part discharging at least one of the water containing the hypochlorous acid and water containing the sterilizing metal ion; and a controller controlling operations of the hypochlorous acid containing water generating part and the sterilizing metal ionic water generating part. When a concentration of the hypochlorous acid in the water containing the hypochlorous acid is relatively low, a concentration of the sterilizing metal ion in the water containing the sterilizing metal ion is relatively high.

Abstract: A method of sterilizing a material, said method comprising the steps of: (a) introducing a solution comprising peroxyacetic acid into a hot gaseous stream to produce a peroxyacetic acid vapor; and (b) contacting such peroxyacetic acid vapor with the material to be sterilized.

Abstract: A method of treating a substance in the form of divided solids, includes the steps of introducing the substance into an enclosure in which there exists an ozonated atmosphere under pressure, conveying the substance in the enclosure with a continuous movement in such a manner that the substance is located continuously in the ozonated atmosphere while it is being conveyed in the enclosure, the substance being conveyed by vibration means causing the enclosure to vibrate, and unloading the substance from the enclosure via the outlet after a single passage of the substance through the enclosure.

Abstract: A gas transfer system including a housing, a pressurized gas canister held by the housing, a first passageway in fluid communication with the pressurized gas canister and configured to supply pressurized pre-sterilization gas from the pressurized gas canister to a fluid flow component, a gas discharge canister held by the housing; and a second passageway in fluid communication with the gas discharge canister and configured to supply post soak gas from the fluid flow component to the gas discharge canister. A humidification system or device is included for the sterile humidification of sterilizing gas. Additional related devices, systems and methods are provided.

Abstract: A solution for disinfecting electronic devices is provided. An ultraviolet radiation source is embedded within an ultraviolet absorbent case. While the electronic device is within the ultraviolet absorbent case, ultraviolent radiation is directed at the electronic device. A monitoring and control system monitors a plurality of attributes for the electronic device, which can include: a frequency of usage for the device, a biological activity at a surface of the device, and a disinfection schedule history for the device. Furthermore, the monitoring and control system can detect whether the device is being used. Based on the monitoring, the monitoring and control system controls the ultraviolet radiation directed at the electronic device.

Abstract: This innovative invention provides a re-activatable Air Purification Pad made of Molecular Sieves/Catalysts, which effectively and efficiently absorbe, disolve and remove the TVOC and odour in the air. This invention can disolve and release the absored TVOC and/or odour when it is heated, which is hence re-activated. This invention, including the product and the process, is effective and efficient in absorbing the TVOC and odour. It is simple in installation and application. It realizes a reduction in tooling and the costs of ongoing maintenance through its re-activation. Moreover, it is safe in use as it is made of heat-resistant materials and doesn't create second polution by its purification embodiments.

Abstract: A volatile composition dispenser and a method of dispensing a volatile composition is provided. The volatile composition dispenser includes a reservoir for containing a volatile composition and a transport member having a first end portion and an opposing second end portion, and an evaporative surface. The first end portion of the transport member is in fluid communication with the reservoir and the second end portion of the transport member is in fluid communication with the evaporative surface. The volatile composition dispenser also includes an air pump in gaseous communication with the reservoir.

Abstract: Disclosed is a clothes treating device. A clothes deodorizing device includes: a bag body for accommodating clothes; an ozone supply device to supply air with ozone into the bag body; an exhaust part arranged on the bag body and used for air exhausted outside the bag body to pass through; and an ozone removing filter arranged on the exhaust part and used for removing ozone in air passing through the exhaust part. The exhaust part is formed by material harder than material forming the bag body and is installed on a first opening part formed in the bag body.

Abstract: Provided is a clothing treatment apparatus capable of preventing air with ozone from leaking from a closed part of a zipper. A clothing deodorizing apparatus includes a bag body for accommodating clothes; an ozone supply apparatus for supplying air with ozone into the bag body; a throwing inlet arranged on the bag body and opened and closed through a zipper; and an end hood for covering a circumference of the closed part of the zipper from an inner surface side of the bag body-. The end hood is formed by fabrics without air permeability. In addition, the zipper is arranged on the throwing inlet in such a manner that the throwing inlet is locked when a zipper slider of the zipper is pulled downwards and the throwing inlet is opened when the zipper slider is pulled upwards.

Abstract: An enclosure for porous members impregnated with volatile substances, such as odor-destroying, air-perfuming, or insect-destroying substances, which may be opened to the extent desired through the use of a slider controlled by the user, to permit the controlled exposure of said porous member to the ambient.

Abstract: Some embodiments of the present disclosure include a device for catching water under a hand dryer while simultaneously deodorizing a surrounding area. The device may include a stand-alone catch tray; and a deodorizing screen positioned within the catch tray such that forced air from the hand dryer contacts the deodorizing screen when the hand dryer is in use causing the deodorizing screen to release a fragrance and deodorize a surround area. The catch tray may include a top tray including a recessed sponge compartment sized to accommodate a sponge; a sponge positioned within the recessed sponge compartment; a base tray attached to the top tray; and a back wall extending upward from the base tray.

Abstract: A protective pipe for a UV lamp for accommodating a tube includes a rod-shaped encasing pipe, wherein a viewing window is provided on the circumferential surface, through which viewing window the radiation, in particular the UV-C radiation, emitted by the tube can escape. A coating made of polytetrafluoroethylene is applied to the inner face of the protective pipe as a reflector. The protective pipe is composed of metal and is surrounded, at least in the region of the viewing window, by an at least partially transparent hose composed of plastic. Preferably, a transparent Teflon material is proposed for the hose.

Abstract: A method and apparatus for electro-hydrodynamic destruction of an aerosol. The method includes receiving air having large aerosols, greater than about 1 micron, and small aerosols, smaller than about 1 micron, and entraining the large aerosols and small aerosols within an airflow. The airflow is directed to an electric field, which causes the large aerosols to react with the electric field to accumulate an electric charge resulting in extraction of the large aerosols from the airflow. The airflow is also directed to a non-thermal plasma such that the small aerosols remain entrained in the airflow and are subject to electro-hydrodynamic (EHD) phenomena. The non-thermal plasma outputs at least one of radicals, excited species, and ionized atoms and molecules capable of reacting with the small aerosols to result in physical and/or chemical destruction of the small aerosols.

Abstract: Disclosed are solid dressings for treating wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator, wherein the haemostatic layer(s) is cast or formed from a single aqueous solution containing the fibrinogen component and the fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen compositions useful for preparing the haemostatic layer(s) of these dressings.

Abstract: Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.

Abstract: A wound-healing and hemostatic sponge of squid ink polysaccharide/chitosan, a preparation method and use thereof are provided. The sponge comprises squid ink polysaccharide and chitosan as carriers and calcium chloride as an initiator for blood coagulation, and the wound-healing and hemostatic sponge of squid ink polysaccharide/chitosan is achieved via a lyophilization technology. Particularly, the preparation method comprises slowly adding a squid ink polysaccharide solution to a chitosan solution to form a uniformly mixed solution, adding a calcium chloride solution to the uniformly mixed solution, forming a gel followed by the gel being frozen and then lyophilized, and achieving the product. The wound-healing and hemostatic sponge has a good absorbing-errhysis effect, a good pro-coagulant effect, fast hemostasis and a complete hemostatic effect, without secondary re-hemorrhage.

Abstract: Adhesive compositions and patches, and associated systems, kits, and methods, are generally described. Certain of the adhesive compositions and patches can be used to treat tissues (e.g., in hemostatic or other tissue treatment applications), according to certain embodiments.

Abstract: Film forming gel compositions, useful in creating conformable and flexible gel bandages, can be formulate from a film-forming polymer, a tackifier, and a volatile solvent. The film forming gels can also include antiseptics, cationic polymer coagulants, fillers, and other additives. The gel compositions form relatively thick films when dried on tissue, and can exhibit enhanced breathability to promote wound healing.

Abstract: The embodiments herein disclose a method of fabricating composite scaffolds for skin tissue regeneration. The methacrylated hyaluronic acid (HAMA) and methacrylated gelatin (GelMA) are synthesized. The poly (glycerol sebacate)-poly(?-caprolactone) (PGS-PCL) microfibrous scaffolds are synthesized. The hydrogel is synthesized. The composite scaffold comprising hydrogel and poly (glycerol sebacate)-poly(?-caprolactone) (PGS-PCL) microfibrous scaffolds is fabricated. A plurality of physico-chemical characteristics of the composite scaffold comprising hydrogel and poly (glycerol sebacate)-poly(?-caprolactone) (PGS-PCL) microfibrous scaffolds are analysed. The physico-chemical characteristics comprises mechanical properties, swelling ratio and enzymatic degradation and scanning electron microscope imaging. The fibroblast cells are encapsulated within the composite scaffold comprising hydrogel and poly (glycerol sebacate)-poly(?-caprolactone) (PGS-PCL) microfibrous scaffolds and hydrogels.

Abstract: Products, such as devices, prostheses, and materials, whose surfaces have been modified in order to impart beneficial properties to these products are disclosed. The surface-modified products have improved biocompatibility compared to a corresponding product that lacks the modification. Following implantation in a subject, the surface-modified products induce a lower foreign-body response, compared to a corresponding unmodified product.

Abstract: Provided are a composition and a sheet, including a mesenchymal stem cells-hydrogel-biodegradable support or a mesenchymal stem cells-hydrogel-nondegradable support and a preparing method thereof. More specifically, in the sheet including a mesenchymal stem cells-hydrogel-biodegradable support or a mesenchymal stem cells-hydrogel-nondegradable support according to the present invention, the high-active mesenchymal stem cells may be applied to a wounded part of a patient with epidermolysis bullosa as it is without isolation using proteases, and in the culturing, an extracellular matrix such as collagen, laminin, fibronectin, and elastin secreted from the mesenchymal stem cells is wholly present on the hydrogel to have an advantageous effect that skin reproduction and re-epithelization abilities are significantly excellent as compared with conventional dressing agents used for epidermolysis bullosa.

Abstract: Provided is an organic/inorganic hybrid-porous biodegradable polymer scaffold, which includes basic ceramic nanoparticles, an animal tissue or cell-derived bioactive first extracellular matrix material, and a biodegradable polymer and in which inner walls of pores are coated with a second extracellular matrix material.

Abstract: Provided herein are methods, compositions, devices, and systems for the 3D printing of biomedical implants. In particular, methods and systems are provided for 3D printing of biomedical devices (e.g., endovascular stents) using photo-curable biomaterial inks (e.g., or methacrylated poly(diol citrate)).

Abstract: A coating agent that has excellent durability and a medical instrument (for example, a needle) that has been coated with the coating agent, are provided. The coating agent includes a condensate (1) of a compound represented by the following general formula (1-1) with a compound represented by the following general formula (1-2), a polydiorganosiloxane (2), and an amino-group-containing polyorganosiloxane (3). The content ratio of the polydiorganosiloxane (2) is 30 to 75 mass %, based on the total mass of the condensate (1), the polydiorganosiloxane (2), and the amino-group-containing polyorganosiloxane (3).

Abstract: A coating agent that has enhanced durability and a medical instrument (for example, a needle) that has been coated with the coating agent, are provided. The coating agent includes a hydroxyl-group-containing polyorganosiloxane represented by the following general formula (1), a polydiorganosiloxane represented by the following general formula (2), and an amino-group-containing polyorganosiloxane represented by the following general formula (3). The polydiorganosiloxane (2) is contained in a proportion of a mass ratio to the amino-group-containing polyorganosiloxane (3) of from 0.7:1 to 3.0:1. The hydroxyl-group-containing polyorganosiloxane (1) is contained in a proportion of 2.4 to 5.5 mass %, based on the total mass of the hydroxyl-group-containing polyorganosiloxane (1), the polydiorganosiloxane (2) and the amino-group-containing polyorganosiloxane (3).

Abstract: The present invention relates to a medical bioabsorbable composite having a fibrous ceramic reinforcing agent and a method for preparing the same and, more particularly, to a medical bioabsorbable composite including a fibrous ceramic reinforcing agent including a fibrous ceramic reinforcing agent having a high aspect ratio, wherein the fibrous ceramic reinforcing agent may have a diameter ranging from 10 to 900 nm, and wherein a length to diameter aspect ratio may be equal to or greater than 5, and a method for preparing the same.

Abstract: A tissue separating device (100) is provided. The tissue separating device (100) includes a canister device (20) including a canister body (21) defining a volume. A tissue retrieval port (36) can be arranged on the canister device (20) and is capable of being arranged in fluid communication with a harvesting device (300) for directing a fatty liposuction aspirate into the volume of the canister device (20). An adjustable height filtration mesh assembly (50) can be arranged within the canister body (21) and can include a filtering mesh (62). A tissue harvesting port (24) can be arranged in the sidewall of the canister body (21) and can be capable of being arranged in communication with a collection device (400) to allow the tissue harvesting port (24) to atraumatically receive a filtered pure fat collected on the filtering mesh (62).

Abstract: This invention relates to the design of tissue covering elements for use in vacuum assisted tissue apposition systems, wherein the geometry of the covering elements favours the application of contractile forces over compressive or extensive forces at the tissue interface.

Abstract: A device for cardiocirculatory assistance constituting a pump for a blood flow includes a body, a pair of covers, and a pair of membranes. The device is provided with a circuit for the passage of a gas or gaseous fluid alternatively under pressure and depressurization so that a reciprocating pumping motion of the membranes is established.

Abstract: A blood pump casing including a unitary body. The unitary body defines an inlet chamber extending along a first axis and having a first radius perpendicular to the first axis. A transition chamber is connected to the inlet chamber and has a wall extending in a circumferential direction around the first axis, the wall has a major radius and a minor radius from the first axis, the major radius being greater than the first radius. A post extends from the transition chamber into the inlet chamber along the first axis, the post tapers in the direction around the first axis toward the inlet chamber. An outlet is connected to the transition chamber and extends along a second axis transverse to the first axis.

Abstract: A method for conveying blood or priming liquid as a medium using a blood pump, measures gas in the medium in a feed line to the pump, in or on the pump, and the pump power is increased only for a short time as a function of the measured gas. A blood pump, in particular a centrifugal pump or diagonal pump, includes a rotor, a housing and a drive, the pump including a gas detector which acts upon the drive when gas is detected.

Abstract: A blood circulation assist system comprising an inflow cannula having a lumen and an insertion device configured to be received therein and to facilitate insertion of a portion of the inflow cannula into a heart chamber. The insertion device includes a shaft having distal and proximal end portions and a plurality of lumens. A first lumen is configured to receive a guidewire and a second lumen is configured to receive a pressurized fluid. A tip connected to the distal end portion of the shaft is configured for insertion into the heart chamber. The tip has a hollow interior communicating with the first shaft lumen. An inflatable member is coupled to the distal end portion of the shaft and includes a hollow interior in fluid communication with the second shaft lumen. The inflatable member is movable between deflated and inflated configurations for releasably securing the insertion device to the inflow cannula.

Abstract: A dialysis machine that includes a valve member having a deformable area configured to deform outwardly away when pressurized fluid is introduced into the valve member. The valve member is configured so that, when a dialysis fluid cassette is disposed in a cassette compartment of the dialysis machine and pressurized fluid is introduced into the valve member, the deformable area obstructs a fluid channel of the dialysis fluid cassette to control dialysis fluid flow therethrough.

Abstract: A dialysis concentrate container for single-use, comprising a container portion (1, 2) which can be filled with dialysis concentrate and a connecting portion (13, 3) connected thereto for connecting the dialysis concentrate container to a dialysis machine, wherein the connecting portion (13, 3) has laterally spaced fluid connection elements (31) for connecting to a fluid outlet and a fluid inlet of the dialysis machine, wherein the container body (1, 2) is formed as a rigid box, wherein the connecting portion (13, 3) is further arranged at the lower end of the container body, wherein the connecting portion (13, 3) is formed by a plate body which can be clamped into a connecting block of the dialysis machine, and on the underside of which the fluid connecting elements (31) are formed, one of which being connected to a fluid inlet of the container body (1) and the other one being connected to a fluid outlet thereof.

Abstract: A device for treating a biological liquid has a housing with a first chamber defining a cavity and which is adapted to receive a liquid to be treated. At least one gas exchanger is at least partly disposed in the first chamber. An inlet portion is formed in a first surface of the housing for the inlet of the liquid to be treated into the chamber. The inlet portion is formed at an acute angle relative to the surface of the housing. Such a device allows a gas exchange in a lung assist method for example.

Abstract: A connection apparatus for sealing to a pathway of a mounting structure includes a body; and a port including a threaded portion extending from the body and a non-threaded portion extending from the threaded portion, the non-threaded portion carrying a gasket, the gasket positioned along the non-threaded portion such that the mounting structure to which the connection apparatus is mounted contacts the gasket prior to the threaded portion engaging a mating threaded portion of the mounting structure, the port providing fluid communication between the body and the pathway of the mounting structure. The body may be that of a valve that supplies any of air, water or oil as an operating fluid to, for example, inlet and outlet valves and a pump chamber of a medical fluid pump of a medical fluid delivery machine.

Abstract: A medical fluid delivery machine including: a medical fluid pump including a pneumatically actuated pump chamber and first and second pneumatically actuated medical fluid valve chambers located respectively upstream and downstream of the pneumatically actuated pump chamber; a compressor for creating positive pressure air; and an accumulator storing the positive pressure air for delivery to at least one of the pneumatically actuated pump chamber, the first pneumatically actuated medical fluid valve chamber, or the second pneumatically actuated medical fluid valve chamber, the accumulator holding an elastic bladder that inflates under positive pressure air from the compressor, creating additional positive pressure that increases the amount of positive pressure air that the accumulator can provide.

Abstract: The invention relates to a system which is a device suitable for carrying out removal of a dialysate volume fraction during a stasis phase so as to optimize ultrafiltration, the safety of the patient, the comfort of the patient, and/or the operation of the cycler.

Abstract: An integrated on-line monitoring and thermostatic heating apparatus for a bioartificial liver device, the apparatus including a blood inlet, a blood pump, an arterial drip chamber, a bioreactor module, a venous drip chamber, and a blood reinfusion port which are connected in sequence. The bioreactor module includes a thermostatic water tank and a bioreactor disposed in the thermostatic water tank. The bioreactor includes a container, and a first partition and a second partition which are disposed in the container. The first partition and the second partition separate the container into three independent parts, that is, a plasma separator, an oxygenator, and a reactor. The plasma separator and the oxygenator are connected through an external connection pipe. The external connection pipe is equipped with a separation pump. The second partition includes a communication hole, and the reactor and the oxygenator are connected through the communication hole.

Abstract: A bioartificial liver device including a bioreaction chamber having a plurality of semi-permeable membranes and a plurality of filter spaces each confined by two adjacent semi-permeable membranes; a plurality of liver cell perfusion ports each communicating with one of the filter spaces for introducing the liver cells into the filter spaces, and a positive peristaltic pump. In the device, the semi-permeable membranes are disposed substantially horizontal with respect to the ground, and the positive peristaltic pump is adapted to drive the plasma flow from the bottom wall of the device to the top wall. The device of the invention improves the cell loading and the area for substance exchange between the blood and the liver cells.

Abstract: Simple-to-use systems, methods, and devices for priming replacement blood treatment devices, for swapping the blood treatment devices out, for replacing swapped-out blood treatment devices, and other related operations are described. In embodiments, a blood treatment device can be primed while a therapy is still running. When the replacement blood treatment device is needed, the therapy can be stopped momentarily (less than a minute) for the rapid and safe swap of the blood treatment device. Blood loss can be minimized. The down time from therapy can be minimized.

Abstract: A conduit arrangement (1) comprises distal and proximal ends (2,3) and two tubular lumens (10,11). Each tubular lumen (10,11) comprises a longitudinal axis extending between the distal and proximal ends (2,3) and independently permits fluid communication between the distal and proximal ends (2,3). The interior of each of the two tubular lumens is made from a biocompatible material. At least a portion of at least one tubular lumen (10, 11) is capable of imparting helical flow on fluid passing through said portion of the tubular lumen (10,11). The helical flow is spiral laminar flow.

Abstract: A pump interface tubing for use in a peristaltic pump includes a tubular core having an outer surface and a treatment on the outer surface. The treatment reduces static charge buildup on the tubular core during operation of the peristaltic pump, and thereby reduces the noise signal that might otherwise undesirably couple to a signal of interest. Treatments include nitrile layers, heat shrink layers, cotton fiber layers, and anti-static sprays.

Abstract: The invention relates to a pre-filled injection device for apportioning set dose of a liquid drug. The housing of the pre-filled injection device internally supports a non-replaceable cartridge (160) having an hollow interior containing a liquid preservative containing drug and externally supporting a removable protective cap (150). The piston rod drive system of the injection device comprises a piston rod abutting a plunger provided inside the cartridge. A needle cannula (130) having a distal part with a distal tip and an opposite proximal part and a lumen there between is insertable into the cartridge. A telescopically movable (110) shield movable from an extended position covering at least the distal tip of the needle cannula to a retracted position exposing at least the distal tip of the needle cannula is further provided.