Abstract: An administration set is configured to couple to a control module of a peristaltic infusion pump. The set can include a pressure plate and a peristaltic tube. The pressure plate can have attachment features structured to mate with corresponding attachment features of the control module such that the pressure plate is maintained in a fixed position relative to the control module. The peristaltic tube can include a first portion having first inner and outer diameters, a second portion downstream of the first portion having second inner and outer diameters, and a transition portion between the first and second portions. The peristaltic tube can be located along the pressure plate and positioned such that when the attachment features of the pressure plate and control module are mated, an expulsor of the control module engages the first portion and an air-in-line detector of the control module engages the second portion.

Abstract: A method, computer program product, and infusion pump assembly for determining a first rate-of-change force reading that corresponds to the delivery of a first dose of an infusible fluid via an infusion pump assembly. At least a second rate-of-change force reading is determined that corresponds to the delivery of at least a second dose of the infusible fluid via the infusion pump assembly. An average rate-of-change force reading is determined based, at least in part upon the first rate-of-change force reading and the at least a second rate-of-change force reading.

Abstract: In some examples, an implantable infusion device (100) using a piezoelectric and/or electrostrictive mechanical pumping catheter (10) includes a reservoir (109) configured to retain for a fluid to be dispensed within a patient, at least one piezoelectric and/or electrostrictive mechanical pumping catheter for dispensing the fluid contained within the reservoir, a transceiver, and a processor (103) to regulate control the operation of the piezoelectric and/or electrostrictive mechanical pumping catheter.

Abstract: The present disclosure relates to a flexible container for an injection device including a flexible bag having an interior volume to be filled with a liquid medicament, an outlet located at a first end of the bag, and a contraction member connected to the bag to displace a second end of the bag located opposite to the first end towards the first end.

Abstract: A digital biomedical device includes a substrate forming a reservoir, a membrane comprising a first layer and a second layer having a strain therebetween, the membrane sealing the reservoir, and a controller configured to activate the membrane and release at least a portion of the strain causing the membrane curl and open the reservoir.

Abstract: The present invention provides a regulator for medicine infusion capable of preventing a flow rate of a liquid medicine to be injected to a patient from exceeding a predetermined flow rate needed for a patient, and controlling the flow rate of the liquid medicine to be uniformly maintained. The regulator for medicine infusion of the present invention provides the advantages of blocking and continuing the inflow of the liquid medicine by the combination of the elements of the membrane member, the resilient plate and the lever and by the adjusted resilience of the resilient plate, and allowing the liquid medicine to flow at a constant rate by adjusting the resilience of the resilient plate and/or the resilience of the membrane member at predetermined levels.

Abstract: A flow meter for intravenous liquids comprising a vertical inlet passage (2), a parallel indicating chamber (9), a ‘U’ shaped flow-resistant liquid passage (6), and an exit chamber (11). Liquid to be dispensed enters the inlet passage (2) via inlet (5) and moves down the passage to a junction with both the ‘U’ shaped flow-resistant passage (6), and the indicator passage. From the junction, the liquid rises up the indicator passage to a height proportional to the flow rate set by an external flow meter, and also through the flow resistant passage, which has an outlet (8) that delivers the liquid to the exit chamber (11) and from there to a patient through an outlet (12). The meter may be formed by an assembly of two injection moulded components, thus reducing manufacturing costs.

Abstract: A status of a battery operated infuser may be detected by measuring a controlled input parameter. The measurement may be used to determine a magnitude of the input parameter and a parameter of the control. For example, control of power input to a motor may be by pulse density modulation. An integral of current over time may serve as a measure of current magnitude and pulse density. The result of the integral may be used to determine the status of the injector. The status may include normal functions for example start of pumping and/or malfunctions such as occlusion or drive disengagement.

Abstract: A system for chemotherapy delivery comprises a plurality of slots to receive a corresponding one of a plurality of cartridges; a plurality of pumps, wherein each of the plurality of pumps is configured to be connected to the corresponding one of the plurality of cartridges, and the plurality of pumps are configured to pump at least one drug contained in at least one of the plurality of cartridges to a patient according to a treatment protocol; a blood glucose sensor communicatively coupled to the plurality of pumps, and configured to measure a blood glucose level of the patient; a processor connected to the plurality of pumps and the blood glucose sensor and configured to adjust a delivery property of the at least one drug according to the measured blood glucose level of the patient.

Abstract: A blood glucose maintenance system for use by hyperglycemic individuals measures their blood glucose level and calculates an appropriate glucose or insulin dosage based on the measurement. Recheck intervals responsive to dosage history are determined. Warning or alert messages or signals are produced if certain measurements or calculations fall outside established normal ranges. It is particularly useful for patients in a hospital or in-patient environment.

Abstract: A wearable drug delivery device has a needle assembly and a drug vial arranged side-by-side. This arrangement makes the device compact so that it can be easily worn around a user's wrist, for example. When the user triggers the device to inject a dose of medication like epinephrine, in an orchestrated sequence, a first spring drives the needle assembly downward and inserts a needle into the user while connecting the needle assembly to the drug vial. A second spring then delivers the dose from the drug vial through the needle and into the user. Advantageously, the small form factor encourages the user to wear the device and have lifesaving medication at the ready.

Abstract: An approach to providing predictable and uniform drug delivery across many instances of an automated drug delivery procedure involves measuring features of the drug delivery system prior to delivery. An automated drug delivery procedure is configured to compensate for or otherwise accommodate the impact of these features based on the measured features. In some examples, the measured features are encoded by value or by reference to an external database onto the drug containing component, for example, by affixing a tag (e.g., RFID, barcode, etc.) to the component. At the time of drug delivery, the features are accessed, for example using the affixed tag, and the drug delivery procedure is controlled according to the features.

Abstract: An adjustable needleless injection system for subcutaneous injection of a liquid medication to a patient is disclosed. The adjustable needleless injection system may include: a medication cartridge that holds the liquid medication, where the medication cartridge includes a cartridge piston, a spring-actuated injector that may be coupled with the medication cartridge and configured to selectively apply force to the cartridge piston, and a charging mechanism configured to charge the spring-actuated injector based on a body type of the patient.

Abstract: The present disclosure relates to a needleless injector including a cap, an injection system, a body, a gas generator, and a percussion device. The body is covered by the cap and is mounted to slide relative to the cap. The percussion device includes a striker that is slidingly mounted along a sliding axis between a rest position and a percussion position and a lock mechanism. The lock mechanism includes a lug and a retention tab. The lug projects from a peripheral face of the striker along an axis that is perpendicular to the sliding axis and has a first support ramp. The retention tab is attached to the cap, and has a second support ramp. The ramps are configured to move the retention tab radially when pushed by the striker from a retaining position to a release position and the retention tab is moved aside to release the striker.

Abstract: A method and apparatus for plasma modifying a workpiece such as a syringe barrel, cartridge barrel, vial, or blood tube is described. Plasma is provided within the lumen of the workpiece. The plasma is provided under conditions effective for plasma modification of a surface of the workpiece. A magnetic field is provided in at least a portion of the lumen. The magnetic field has an orientation and field strength effective to improve the uniformity of plasma modification of the interior surface of the generally cylindrical wall. A vessel made according to the process or using the apparatus described above. A pharmaceutical package comprising the syringe barrel or vial containing a pharmaceutical preparation, secured with a closure.

Abstract: A finger grip for receiving and retaining a syringe body of an injection syringe. The finger grip is easily pressed directly onto the syringe and employs a centering feature and a pair of one way, flexible latches that allow easy attachment to a syringe body yet ensures retention during normal and abnormal use. If a high horizontal component force is applied during normal or abnormal use, the finger grip will not become disconnected in an uncontrolled fashion from the syringe body, which might cause injury and/or damage to a patient being injected. The flexible latches may prevent detachment of the finger grip from the syringe below separation force of about 25 lbs.

Abstract: A syringe assembly including a plunger rod having a first end, a second end, and a rod portion extending therebetween, wherein at least a portion of the rod portion is flexible is disclosed. The flexible portion of the rod portion allows a stopper to be moved between a first position and a second position within a syringe barrel while the overall length of the syringe assembly remains the same throughout the movement between the first position and the second position. In another embodiment, a syringe assembly including a restraining member adapted to communicate with the flexible portion of the rod portion such that movement of the first end of the plunger rod in a first direction actuates movement of the second end of the plunger rod in a second direction different than the first direction is disclosed.

Abstract: A plunger cover for use with a syringe includes a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe. The central portion can, for example, be more rigid than the sealing portion. The sealing portion and the central portion are connected in an overmolding process. The sealing portion can, for example, be formed from a thermoplastic elastomer or a thermoplastic polyurethane. The central portion can, for example, be formed from polypropylene, acrylonitrile butadiene styrene, polycarbonate or copolymers thereof.

Abstract: An assembly comprises an electric consumer, an electric voltage source adapted to power the electric consumer, and user operated actuation means. The electric voltage source is operatable between a first state in which a first voltage is generated and a second state in which a second higher voltage is generated. The user operated actuation means is operatable from a first to a second state and adapted to thereby operate the electric voltage source from the first to the second state, and operatable from the second state to the first state and adapted to thereby operate the electric voltage source from the second to the first state.

Abstract: A system for injecting includes a cartridge body defining a proximal opening and a distal needle interface. The system also includes a plunger member defining a plunger interior and configured to be manually manipulated to insert a stopper member relative to the cartridge body. The plunger member includes a needle retention feature disposed in the plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The system further includes a needle hub assembly coupled to the distal needle interface of the cartridge body. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latching member configured to couple the needle to the hub. The needle is retractable into plunger interior upon manipulation of the plunger member to actuate the energy-storage member latching member.

Abstract: A system for mixing drug products and injecting includes a syringe body, proximal and distal stopper members disposed in the syringe body, a plunger member, and a needle hub assembly coupled to the distal needle interface of the syringe body. The proximal and distal stopper members form a proximal drug chamber between there between and a distal drug chamber between the distal stopper member and a distal end of the syringe body. The plunger member includes a needle retention feature, an energy-storage member, and an energy-storage member latching member all disposed in disposed in a plunger interior. First and second sizes of the respective proximal and distal drug chambers can be modified by movement of the proximal and distal stopper members relative to the syringe body. The needle is at least partially retractable into plunger interior upon manipulation of the plunger member relative to the syringe body.

Abstract: A method and apparatus for injecting supportive and therapeutic agents into bone marrow. During conventional chemotherapy for leukemia, lymphoma, multiple myeloma and other bone related diseases, chemotherapeutic agents are typically injected intravenously. Intravenous injection, however, as a method of chemotherapy, has a number of potential disadvantages. By injecting therapeutic agents directly into the bone marrow using the present method and apparatus, these disadvantages can be avoided. A stronger needle with a shorter and sharper tip, when compared to a conventional intravenous or sternal puncture needle, designed to optimally administer therapeutic agents into bone marrow without causing injury is disclosed. The method includes injecting therapeutic agents into large reservoirs of bone marrow in accessible areas such as ilium and sternum is most likely to have a significant effect in treating bone marrow diseases.

Abstract: An injectable material injection device includes a cannula that slides inside a hypodermic needle. The hypodermic needle includes a beveled tip. The cannula includes a base that is configured to establish a sealed connection.

Abstract: A drug delivering apparatus includes a drug container, a pre-filled syringe including a cylindrical container having a nozzle portion and an injection needle attachment portion, and a connecting tool configured to allow communication between the inside of the cylindrical container and the inside of the drug container. The connecting tool further includes a nozzle insertion portion. The pre-filled syringe further includes a cap member configured to be detachably fitted on the injection needle attachment portion, the cap member having an opening into which the nozzle insertion portion can be inserted. The injection needle attachment portion has a guiding groove in the inner periphery thereof. In the state where the cap member is fitted on the injection attachment portion, at least a part of the edge of the opening is located on the inner side relative to the bottom portion of the guiding groove.

Abstract: A medication delivering injector having electrical sensor pads in communication with a microcontroller such that contact with the patient's skin and the angle at which the injector is held against the skin and the steadiness with which the injector is being held can be ascertained. A haptic vibrator and audio speaker produce a vibration which is variable in pitch in such a manner that biofeedback is provided to the injector user as to the pressure, angle and steadiness with which they are holding the injector. Multiplexed onto the electrical sensor pads, is a TENS (Transcutaneous Electrical Nerve Stimulation) generator which is operational (at the user's choice) just before and during the injection to interrupt or quench the pain of tissue perforation often accompanied with needle injections.

Abstract: An apparatus and method for performing neurological intervention may include a cylindrical body including a tapered threaded portion that screws into a pre-drilled hole in a subject. Additionally, the apparatus may include a connector having a probe lock-screw that is disposed on the cylindrical body, at an end opposite to the tapered threaded portion. The connector may further include an opening to receive a probe. The probe may be inserted into a subject via the apparatus, and a depth of insertion of the probe within the subject may be adjusted by the probe lock-screw.

Abstract: An inhalation device including a housing, which encloses a liquid reservoir in which the liquid is stored before discharge, and an applicator head with a nebulization chamber and an applicator piece connected thereto, wherein the applicator piece is designed either as a mouthpiece, to be received in the mouth of a patient, or as an inhalation mask, to sealingly cover the mouth, the nose, or the mouth and the nose. The inhalation device furthermore has a discharge channel which connects the liquid reservoir to the applicator head. The inhalation device includes at the end of the discharge channel, a nozzle plate with a large number of nozzle openings which serve to generate an inhalation mist and through which the liquid from the liquid reservoir is conveyed into the nebulization chamber.

Abstract: A vaporizer cartridge includes a base, inner and outer substantially concentric walls extending from the base and defining a vaporization chamber between the outer and inner walls adapted for containing at least one vaporizable substance, and a heating receptacle opening extending through the base within a perimeter of the inner wall adapted for receiving a heating element inserted into the heating receptacle opening, wherein a top edge of the outer wall forms an open top rim adapted for coupling to a mouthpiece. The vaporizer cartridge may also have a mouthpiece with a top opening, a central open bore, and a bottom opening sealably coupled to the open top rim. A vaporizer apparatus having a heating component and a vaporizer cartridge is provided, as is a method of making a vaporizer cartridge and a method of vaporizing a consumable substance.

Abstract: This atomization unit is provided with a liquid holding member that holds an aerosol source, a heating element that atomizes the aerosol source held by the liquid holding member, and a cover member that restricts the amount of the aerosol source supplied to the liquid holding member. The liquid holding member has a shape that extends along a prescribed direction. At least a portion of the inner side surface of the liquid holding member in an orthogonal direction which is orthogonal to the prescribed direction is in contact with or in close proximity to the heating element. At least a portion of the outer side surface of the liquid holding member in the orthogonal direction is covered by the cover member.

Abstract: Methods and apparatus treat a respiratory disorder. For example, a pressure generator supplies a flow of air at positive pressure to a patient's airway through a patient interface. A sensor generates a signal representing respiratory flow rate of the patient. A controller controls the pressure generator to provide to the patient interface a ventilation therapy having a base pressure. The controller computes a measure of ventilation of the patient from the signal. The controller computes a measure of flow limitation from an inspiratory portion of the signal. The controller computes a ratio of the measure of ventilation and an expected normal ventilation. The controller adjusts a set point for the base pressure of the ventilation therapy based on the measure of flow limitation. The adjustment may further depend on a comparison between the ratio and a relative ventilation threshold that increases as the measure of flow limitation increases.

Abstract: A gas flow monitoring system (100, 200A, 200B, 400, 600, 700) for monitoring a patient gas flow and having pressure sensors (114), a pneumatic system (110), valves (120), and a pump (116), the system including a controller (112, 710) configured to: determine whether a test mode is selected; configure the pump and the valves to pressurize at least a portion of the pneumatic system when in a test mode; obtain sensor information indicating pressure within at least a portion of the pneumatic system, when in the test mode; and determine whether a leak test fails based upon at least the sensor information.

Abstract: Apparatus and methods automate selection of patient interface(s) according to their size, such as with processing in a processor(s) or in a server(s). Image data captured by an image sensor may be received. The captured image data may contain facial feature(s) of an intended user of the patient interface. The facial features may be captured in association with a predetermined reference feature of known dimension(s). The user's facial feature(s) and the reference feature may be detected in the captured image data. Image pixel data of the image may be processed to measure an aspect of the detected facial feature(s) based on the reference feature. A patient interface size may be detected from standard patient interface sizes based on a comparison between the measured aspect of the facial feature(s) and a data record relating sizing information of the standard patient interface sizes and the measured aspect of the facial feature(s).

Abstract: A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.

Abstract: Various embodiments are described herein to reduce sound sensitivities, improve state regulation, and/or reduce auditory processing and social engagement deficits in individuals with such deficiencies by recruiting the anti-masking functions of the middle ear muscles in order to optimize the transfer function of the middle ear for the processing of human speech. In certain embodiments, an individual may be subjected to a training protocol comprising one or more training sessions. During each training session, acoustic stimuli are provided to a subject for a period of time, with or without accompanying visual stimulation. A user response may be determined, for example, before beginning the protocol, during a session, after a session, and/or upon completion of the protocol. Such user response may be employed to adjust the acoustic stimulation, and the adjusted acoustic stimulation may be provided to the subject during a subsequent training session (or at a subsequent time within the same training session).

Abstract: An aroma emitting pacifier for an infant gives off a predetermined scent by evaporation of volatile essential oils or similar substances. The aroma may be, for example, mint, menthol or eucalyptus, which may help relieve nasal congestion. The aroma emitting pacifier is constructed to prevent evaporation of the essential oil before activation, so that the nipple does not become contaminated with a flavor the infant may find unpalatable, and so that the oil is conserved until it is desired to administer it to the infant.

Abstract: The present invention provides a children's guided breathing and meditation, mindfulness, and yoga toy. The children's toy includes a body containing one or more lights visible behind a translucent visor; a sound device that includes a flash memory integrated circuit; a microcontroller; an amplifier; a battery, and a speaker. The microcontroller is programmed with nature sounds recordings, guided breathing and meditation recordings, guided mindfulness recordings, and guided yoga recordings that when played by the child, are coordinated with light generated by the light emitting diodes (LEDs).

Abstract: An audio signal generation device (20) includes: an acquirer (210) configured to acquire biological information of a human subject; an audio signal generator (245) configured to generate an audio signal based on at least one of a plurality of pieces of sound information; and a switching cycle decider (241) configured to decide a switching cycle, such that first sound information switches to second sound information at a cycle that is in accordance with the biological information, the first sound information and the second sound information being included in the plurality of sound information pieces, and the audio signal generator (245) generates an audio signal based on the second sound information, at the switching cycle decided by the switching cycle decider (241).

Abstract: A catheter apparatus formed for insertion into a patient's body cavity and/or subcutaneous tissue, the catheter apparatus has an outer cannula that forms an outer lumen, the outer cannula has a length extending to distal portion, the catheter apparatus includes tubular proximal ends for directing the flow of substances to and from a patient's body.

Abstract: Devices for preventing and/or otherwise inhibiting biofilm formation include a lumen and/or cavity coupled with a wall configured for holding oils, which leach through the wall of the device to the surface, the oil at the surface creating a smooth surface coating.

Abstract: A medical device may include a handle having a first handle portion and a second handle portion. The first handle portion may be rotatable relative to the second handle portion. The medical device may also include a deflectable shaft coupled to and extending distally of the first handle portion. A port may be positioned on the first handle portion and a control knob may be coupled to the shaft.

Abstract: In some examples, a burr hole cap assembly includes one or more markers that indicate a rotational orientation of a therapy delivery member relative to the burr hole cap assembly, where the therapy delivery member extends through an opening defined by the burr hole cap assembly. In addition, in some examples, the burr hole cap assembly includes a feature that indicates the rotational orientation of the therapy delivery member after the therapy delivery member is implanted in the patient. The feature can include the one or more markers in some examples.

Abstract: Delivery devices, systems, and methods related thereto may be used in humans for spinal delivery of cells, drugs or vectors. Thus, the system enables subpial delivery, which leads to a near complete spinal parenchymal AAV9-mediated gene expression or distribution in both white and grey matter.

Abstract: The invention relates to a method for introducing a catheter in a vein, comprising the following steps: puncturing the vein, introducing a guide in the punctured vein, fixing a catheter on the distal coupler of a connector, introducing a mandrel in the catheter, introducing the set formed by the catheter and the mandrel in the vein by having said set slide on the guide, withdrawing the mandrel and the guide, and connecting a fluid injection device on the second proximal coupler of the connector.

Abstract: An expandable introducer assembly includes a dilator subassembly extending from a proximal end to a distal end. The dilator subassembly includes a dilator having an insertion portion disposed adjacent the distal end, an expansion portion disposed adjacent the distal end, and a tapered transition portion disposed between the insertion and expansion portions. The dilator subassembly includes a distal sheath disposed in overlaying relationship with the insertion portion of the dilator. An introducer subassembly is disposed in coaxial relationship with the expansion portion of the dilator, and includes a valve disposed adjacent the proximal end and an introducer sheath extending from the valve in overlaying relationship with the expansion portion of the dilator.

Abstract: A tubing assembly having a signal generator placement control device for use in conjunction with electronic catheter guidance systems. The control device facilitates control of the position the guidance systems' signal generator relative to the end of the tubing assembly. The tubing assembly includes a tubular insulator coupled to one end of the control device, and the tubing assembly includes a tubular connector attached to the other end of control device. Also, the tubing assembly includes a catheter attached to the tubular connector and an end member attached to the catheter.

Abstract: A vascular catheter wire clamp is provided. The vascular catheter clamp includes an elastic body, a clamping shaft, and a clamping shaft receiving passageway. The elastic body includes a first arm having a first retention surface, a second arm having a second retention surface, and a bent section connecting the first arm and the second arm such that first arm away from the bent section and parallel with the second arm. The clamping shaft extends inward from outward facing surface of the first arm and includes a retention member positioned along an end thereof. The clamping shaft receiving passageway is positioned through the second arm and corresponds with the clamping shaft and the retention member.

Abstract: Catheter assemblies and methods for making and using catheter assemblies are disclosed. An example a catheter assembly includes a catheter shaft and a balloon attached to the catheter shaft. The balloon includes a body and a proximal waist portion. The proximal waist portion has a proximal end. The catheter assembly also has a fiber braid including one or more individual filaments disposed along the balloon. The fiber braid has a proximal end aligned with the proximal end of the waist portion. The catheter assembly also has a polymer sleeve disposed on the catheter shaft, wherein in the polymer sleeve abuts the proximal end of the balloon waist and the proximal end of the braid.

Abstract: The present disclosure relates to a drainage catheter and methods of use for providing improved catheterization procedures, such as during a percutaneous nephrostomy. The drainage catheter includes a body comprising a first tube segment and a second tube segment connected to one another at a curved end portion to form a continuous body structure. An inner surface of the curved end portion includes one or more drainage openings extending therethrough, with an outer surface of the curved end portion free of drainage openings to minimize potential clogging. The openings are in communication with a lumen that extends through the drainage catheter to provide a pathway for removing fluid from the kidney. The drainage catheter is inserted into the kidney via a first insertion site and exits via a second insertion site to minimize the potential for accidental removal of the catheter.

Abstract: An implantable valve assembly including a drainage catheter having a central lumen transitioning into a plurality of distinct branch lumen made of a shape memory material. A bioabsorbable dip coating secures the distal end of the plural distinct branch lumen together in physical contact with one another. Each branch lumen has an outer perimeter comprising at least one of a first outer surface section and a second outer surface section. in a secured state with the plural distinct branch lumen held together by the dip coating fluid is prohibited from passing through the holes defined in the first outer surface section. Bioabsorbable blocking members disposed about the outer perimeter of the assembled branch lumen mask holes defined in the second outer surface section prohibiting fluid from entering therein. In a time staggered fashion, the bioabsorbable elements absorb exposing new holes through which the fluid drains.

Abstract: An apparatus includes a guide member configured with stress limiting features which function to prevent the stress from bending the guide member causing ovalization of the guide member. An apparatus for bending a guide member includes a ram die and a pressure die which are configured to fully encircle the portion of the guide member during the bending operation. A fixture for supporting a guide member during bending is configured to fully encircle sections of the guide member during bending.