Patents Issued in May 31, 2018
  • PAR1 MODULATION TO ALTER MYELINATION
    Publication number: 20180147209
    Abstract: Materials and methods for modulating protease activated receptor 1 (PAR1) activity to alter myelination are provided.
    Type: Application
    Filed: November 16, 2017
    Publication date: May 31, 2018
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Isobel A. Scarisbrick, Hye-Sook Yoon, Kristen L. Drucker
  • DOSING REGIMEN ASSOCIATED WITH LONG ACTING INJECTABLE PALIPERIDONE ESTERS
    Publication number: 20180147210
    Abstract: The present invention provides a method of treating patients in need of treatment with long acting injectable paliperidone palmitate formulations.
    Type: Application
    Filed: January 25, 2018
    Publication date: May 31, 2018
    Applicant: Janssen Pharmaceutica NV
    Inventors: An Vermeulen, Alfons Wouters, Srihari Gopal, Vivek Kusumakar, Peter H. Lewyn-Briscoe, Mahesh Samtani
  • COMPOSITIONS AND METHODS FOR TREATING AN INFECTION
    Publication number: 20180147211
    Abstract: A method of treating or preventing a bacterial infection of a subject may include combining linezolid and a diluent to form a treatment solution and topically administering the treatment solution to the subject to bath a skin area with the treatment solution. The treatment solution may be made using linezolid oral tablets.
    Type: Application
    Filed: January 26, 2018
    Publication date: May 31, 2018
    Applicant: CMPD LICENSING, LLC
    Inventor: Jay Richard Ray, II
  • COMPOSITIONS AND METHODS FOR TREATING AN INFECTION
    Publication number: 20180147212
    Abstract: A method of treating or preventing a bacterial infection of a subject may include combining levofloxacin and a diluent to form a treatment solution and topically administering the treatment solution to the subject to bath a skin area with the treatment solution. The treatment solution may include levofloxacin oral solution.
    Type: Application
    Filed: January 26, 2018
    Publication date: May 31, 2018
    Applicant: CMPD LICENSING, LLC
    Inventor: Jay Richard Ray, II
  • METHODS OF COSMETICALLY TREATING SKIN CONDITIONS WITH A COSMETIC PERSONAL CLEANSING COMPOSITION
    Publication number: 20180147213
    Abstract: A method of treating a skin condition including applying a rinse-off multi-phase cleansing composition including a cleansing phase including an anionic surfactant and zinc pyrithione and a benefit phase including a benefit agent.
    Type: Application
    Filed: January 24, 2018
    Publication date: May 31, 2018
    Inventors: Karl Shiqing Wei, Jason Edward Cook, Kevin John Mills
  • D20 STABILIZED PHARMACEUTICAL FORMULATIONS
    Publication number: 20180147214
    Abstract: Provided herein is an ophthalmic composition formulated in deuterated water. Also disclosed herein are methods of treating, ameliorating, or reducing ophthalmic conditions or diseases by administering to an eye of an individual in need thereof an effective amount of an ophthalmic composition as described herein.
    Type: Application
    Filed: May 27, 2016
    Publication date: May 31, 2018
    Inventors: Gregory I. OSTROW, Kenneth J. WIDDER, David S. BAKER
  • ORAL TESTOSTERONE UNDECANOATE THERAPY
    Publication number: 20180147215
    Abstract: The present disclosure provides methods and compositions for testosterone replacement therapy. The methods and compositions employ a fixed dose dosing regimen that does not require titration or dose adjustments and that can provide a therapeutically effective amount of a testosterone ester while avoiding unacceptably high testosterone levels.
    Type: Application
    Filed: November 28, 2017
    Publication date: May 31, 2018
    Applicant: Lipocine Inc.
    Inventors: Nachiappan Chidambaram, Satish Kumar Nachaegari, Mahesh V. Patel, Kilyoung Kim
  • METHODS OF TREATING PANCREATIC CANCER
    Publication number: 20180147216
    Abstract: Described herein are methods and compositions for the treatment of pancreatic cancer in a subject in need thereof. The pancreatic cancer may be resistant to other therapeutic regimens. The methods may comprise administering ARDA compounds to the subject.
    Type: Application
    Filed: October 2, 2015
    Publication date: May 31, 2018
    Inventors: Vincent C.O. Njar, Puranik Purushottamachar, Andrew K. Kwegyir-Afful
  • PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 4-PREGENEN-11BETA-17-21-TRIOL-3,20-DIONE DERIVATIVES
    Publication number: 20180147217
    Abstract: The present invention relates to pharmaceutical compositions comprising 4-pregenen-11?-17-21-triol-3,20-dione derivatives, and their use as pharmaceuticals as modulators of the glucocorticoid receptors (GR) and/or the mineralocorticoid receptors (MR). The invention relates specifically to the use of these compounds and their pharmaceutical compositions to treat ocular conditions associated with the glucocorticoid receptors (GR) and/or the mineralocorticoid receptors (MR).
    Type: Application
    Filed: June 30, 2017
    Publication date: May 31, 2018
    Inventors: Jeffrey L. Edelman, Alissar Nehme
  • Methods for Accelerated Return of Skin Integrity and for the Treatment of Impetigo
    Publication number: 20180147218
    Abstract: Methods of treatment and dosage regimes using hydrophobic gel or foam compositions comprising a tetracycline antibiotic for accelorating the return of skin integrity and or in treating or alleviating a disorder including impetigo, acne, rosacea, a skin disease caused by a bacteria or a tetracycline antibiotic responsive disease, wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin, or mucosa or an eye.
    Type: Application
    Filed: November 17, 2017
    Publication date: May 31, 2018
    Inventors: Dov Tamarkin, Elana Gazal, Rita Keynan, Meir Eini, David Schuz
  • ENOLASE INHIBITORS AND METHODS OF TREATMENT THEREWITH
    Publication number: 20180147219
    Abstract: Provided herein are compounds of the formula (I) wherein the variables R1, R2, R3, R4, X1, X2, Y1, and A1 are as defined herein. Such compounds may be used, for example, for the inhibition of enolase enzymes, including preferential inhibition of one isoenzyme of over one or more of the other isoenzymes. Methods of treatment using these compounds, as well as pharmaceutical compositions thereof, are also provided.
    Type: Application
    Filed: March 9, 2016
    Publication date: May 31, 2018
    Inventors: Florian MULLER, David S. MAXWELL, William G. BORNMANN, Yu-Hsi LIN, Basvoju A. BHANU PRASAD, Zhenghong PENG, Duoli SUN, Nikunj SATANI, M. Emilia DI FRANCESCO, Ronald A. DEPINHO, Barbara CZAKO, Federica PISANESCHI
  • HONOKIOL AND MAGNOLOL FORMULATIONS WITH INCREASED STABILITY AND IMPROVED UPTAKE, AND METHODS OF USE THEREOF
    Publication number: 20180147220
    Abstract: Described herein are formulations and methods for treating, managing, or preventing sleeplessness or restlessness, for increasing focus or concentration, or for decreasing anxiety. The formulations comprise honokiol and magnolol, which are present in magnolia bark extract, in admixture with one or more polyunsaturated fatty acids, such as those found in virgin salmon oil. As compared to other lipid formulations of honokiol and magnolol, the formulations show improved stability and increased uptake.
    Type: Application
    Filed: January 18, 2016
    Publication date: May 31, 2018
    Inventor: Bomi P. Framroze
  • GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF
    Publication number: 20180147221
    Abstract: Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said gycan therapeutics, e.g. in cancer therapy.
    Type: Application
    Filed: April 23, 2016
    Publication date: May 31, 2018
    Applicant: KALEIDO BIOSCIENCES, INC.
    Inventors: Geoffrey A. von Maltzahn, Yvonne J. Yamanaka, Jared Silverman, Jack Milwid, Jacob R. Rubens, John M. Geremia
  • GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
    Publication number: 20180147222
    Abstract: Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.
    Type: Application
    Filed: June 15, 2017
    Publication date: May 31, 2018
    Inventors: Geoffrey A. von Maltzahn, Jared Silverman, Yvonne J. Yamanaka, John Miles Milwid, John M. Geremia
  • BOTULINUM NEUROTOXIN INHIBITORS
    Publication number: 20180147223
    Abstract: Present invention discloses a method of treating an individual suffering from botulism by inhibiting botulinum neurotoxins.
    Type: Application
    Filed: November 29, 2016
    Publication date: May 31, 2018
    Applicant: Prime Bio, Inc
    Inventors: Bal Ram Singh, Kruti Patel
  • METHODS FOR TREATING TUMORS IN SITU INCLUDING INTRATUMOR INJECTION OF CYTOTOXIC PARTICLES AND IMMUNE CHECKPOINT BLOCKADE THERAPY
    Publication number: 20180147224
    Abstract: Disclosed are compositions, kits, and methods for treating cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat a tumor in a subject in situ. The compositions, kits, and methods comprise or utilize cytotoxic particles, immune checkpoint inhibitors, and/or T-cell stimulatory agents.
    Type: Application
    Filed: May 16, 2016
    Publication date: May 31, 2018
    Applicant: University of Iowa Research Foundation
    Inventors: Aliasger K. Salem, Amani Makkouk, Vijaya B. Joshi, George Weiner
  • USE OF NAD PRECURSORS FOR BREAST ENHANCEMENT
    Publication number: 20180147225
    Abstract: Certain embodiments of the invention provide a method for breast enhancement in a female mammal (e.g., a human) in need thereof, comprising administering an effective amount of a nicotinamide adenine dinucleotide (NAD) precursor to the mammal.
    Type: Application
    Filed: November 29, 2017
    Publication date: May 31, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Charles M. Brenner, Po Hien Ear, Ankita Chadda, Amy Sindler, Marie E. Migaud
  • METHODS AND ASSAYS FOR COMBINATION TREATMENT OF CANCER
    Publication number: 20180147226
    Abstract: The technology described herein is directed to the treatment of cancer, e.g. methods and assays relating to selecting and administering a chemotherapy with or without an EZH2 inhibitor.
    Type: Application
    Filed: January 9, 2018
    Publication date: May 31, 2018
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Christine M. FILLMORE, Carla F. KIM
  • NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND THEIR USES
    Publication number: 20180147227
    Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.
    Type: Application
    Filed: January 23, 2018
    Publication date: May 31, 2018
    Inventors: Karl D. Normington, David A. Sinclair, David J. Livingston, James M. Mckearin, Bruce Szczpankiewicz, Jonathan N. Kremsky
  • USE OF AN AMINOGLYCOSIDE FOR NONSENSE MUTATION SUPPRESSION AND THE TREATMENT OF DISEASE
    Publication number: 20180147228
    Abstract: Methods of using and pharmaceutical compositions comprising (2R,3S,4R,5R,6S)-5-amino-6-(((1R,2S,3S,4R,6S)-4,6-diamino-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)- 2-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol are disclosed, including methods of treating or preventing a nonsense mutation mediated disease associated with premature translation termination or a premature stop codon resulting from a germline or somatic nonsense mutation.
    Type: Application
    Filed: June 3, 2016
    Publication date: May 31, 2018
    Inventor: Ramil L. BAIAZITOV
  • MATERIALS AND METHODS FOR TREATING BACTERIAL INFECTIONS USING C-1 GENTAMICIN
    Publication number: 20180147229
    Abstract: Various aspects relate to the use of C-1 gentamicin as an antibiotic effective for the treatment of a bacterial infection, a genetic disorder, or cancer in a subject.
    Type: Application
    Filed: June 3, 2016
    Publication date: May 31, 2018
    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventors: Bruce A. MOLITORIS, Mark C. WAGNER, Ruben M. SANDOVAL, Mark Gerard GOEBL
  • THERAPEUTIC AGENT FOR DRY EYE CHARACTERIZED BY BEING APPLIED TO EYE OF DRY EYE PATIENT WEARING SOFT CONTACT LENS
    Publication number: 20180147230
    Abstract: An ophthalmic solution, which comprises diquafosol tetrasodium salt and is free from benzalkonium chloride, treats onset and/or exacerbation of dry eye symptom caused by wearing soft contact lenses.
    Type: Application
    Filed: June 3, 2016
    Publication date: May 31, 2018
    Applicant: SANTEN PHARMACEUTICAL CO., LTD.
    Inventors: Yoshihiro OSHITA, Hitoshi NAKAZAWA, Isao MATSUOKA, Asuka KAMIMURA
  • METHOD FOR TREATMENT AND PROGNOSIS OF COLORECTAL CANCER
    Publication number: 20180147231
    Abstract: The invention relates to the treatment and prognosis of colorectal cancer, especially proximal colorectal cancer. It also relates to identifying patients with colorectal cancer who are likely to respond to therapy with an inhibitor of interleukin 22 signalling.
    Type: Application
    Filed: May 20, 2016
    Publication date: May 31, 2018
    Inventors: Sarah McCuaig, Fiona Margaret Powrie, Nathaniel Richard West
  • COMBINATION THERAPY USING PDK1 AND PI3K INHIBITORS
    Publication number: 20180147232
    Abstract: The present invention relates to methods and compositions for inhibiting growth and proliferation of cancer cells resistant to PI3K inhibition using a combination of PDK1, SGK1 and PI3K inhibitors. The present invention is also directed to methods of treating cancer in a subject exhibiting cancer cells resistant to PI3K inhibition, comprising administering inhibitors of PI3K in combination with inhibitors of PDK1 and/or SGK1 to the subject.
    Type: Application
    Filed: January 17, 2018
    Publication date: May 31, 2018
    Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: Pau Castel, Jose T. Baselga, Maurizio Scaltriti
  • MICRO-RNAS AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT AND DIAGNOSIS OF SEROTONIN-, ADRENALIN-, NORADRENALIN-, GLUTAMATE-, AND CORTICOTROPIN-RELEASING HORMONE- ASSOCIATED MEDICAL CONDITIONS
    Publication number: 20180147233
    Abstract: microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.
    Type: Application
    Filed: January 18, 2018
    Publication date: May 31, 2018
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Alon CHEN, Eran HORNSTEIN, Orna ISSLER, Sharon HARAMATI
  • COMPOSITIONS AND METHODS FOR TREATMENT OF FIBROMYALGIA
    Publication number: 20180147234
    Abstract: Provided herein are methods and compositions for the treatment of Fibromyalgia (FM) or Fibromyalgia syndrome (FMS). One aspect provides treating a subject having, suspected of having, or diagnosed with FM or FMS with a pharmaceutically effective amount of an iron carbohydrate complex.
    Type: Application
    Filed: May 27, 2016
    Publication date: May 31, 2018
    Inventors: Erin Michelle Malloy, Todd Koch, Marc L. Tokars
  • ALLERGY VACCINE COMPOSITION
    Publication number: 20180147235
    Abstract: The present invention provides an allergy vaccine composition that is useful as a prophylactic or therapeutic agent for an allergic disease and can safely and effectively induce immune tolerance. The vaccine composition is to be administered to a human or animal with an allergic disease for the prevention or treatment of the allergic disease.
    Type: Application
    Filed: April 28, 2016
    Publication date: May 31, 2018
    Applicant: NITTO DENKO CORPORATION
    Inventors: Kyohei MATSUSHITA, Masahiro FUKASAKA, Takuya SHISHIDO, Daisuke ASARI, Katsuyuki OKUBO, Mitsuhiko HORI
  • METHOD OF SUPPRESSING INFLAMMATION AND PROMOTING REPAIR OF INJURED NEURAL TISSUES WITH CARBOXYL-FUNCTIONALIZED POLYURETHANE NANOPARTICLES
    Publication number: 20180147236
    Abstract: The present invention provides a method of suppressing inflammation and promoting repair of an injured neural tissue in a subject in need thereof, including administering to the injured neural tissue an effective amount of a carboxyl-functionalized polyurethane nanoparticle. The method of the present invention significantly suppresses immune responses by inhibiting pro-inflammatory cytokine production and facilitates neurological recovery, and thus it may be applied directly in patients going through neurosurgery.
    Type: Application
    Filed: November 25, 2016
    Publication date: May 31, 2018
    Inventors: Shan-Hui Hsu, Yen-Jang Huang, Po-Hao Huang, Yi-Hua Hsu
  • NANOPARTICLES FOR USE AS A THERAPEUTIC VACCINE
    Publication number: 20180147237
    Abstract: The present invention relates to the field of human health and more particularly concerns nanoparticles for use as a therapeutic vaccine in the context of radiotherapy in a subject suffering of a cancer, in particular of a metastatic cancer or of a liquid cancer.
    Type: Application
    Filed: May 27, 2016
    Publication date: May 31, 2018
    Inventors: JULIE MARILL, AGNES POTTIER, LAURENT LEVY
  • COMPOSITION OF IRON SUCROSE AND PROCESS FOR ITS PREPARATION
    Publication number: 20180147238
    Abstract: The present invention relates to composition of iron sucrose and process for its preparation. The present invention also related to a process for the preparation of iron sucrose suitable for the iron sucrose composition.
    Type: Application
    Filed: May 27, 2016
    Publication date: May 31, 2018
    Applicant: SUN PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: Rajamannar THENNATI, Shriprakash Dhar DWIVEDI, V S N Murty KADIYALA, V, Kanaksinh Jesingbhai JADAV, Bharat Avcharbhai KAILA, Keyur Shashikant THAKER, Binaka Rahul DOLE
  • METHODS FOR CULTURING AND/OR DIFFERENTIATING HEMATOPOIETIC STEM CELLS INTO PROGENITORS AND USES THEREOF
    Publication number: 20180147239
    Abstract: The present description relates to in vitro methods for culturing hematopoietic stem cells (HSCs) under mild hyperthermia conditions (e.g., between 38° C. and 40° C.) in the presence of a pyrimidoindole derivative agonist of hematopoietic stem cell expansion. The combined use of mild hyperthermia and the pyrimidoindole derivative act synergistically to promote expansion of CD34+ HSCs and/or differentiation into progenitor cells (e.g., megakaryocytic progenitors). The present description also relates to in vitro expanded cell populations of HSCs and/or progenitors, as well as uses thereof in therapy (e.g., transplantation).
    Type: Application
    Filed: June 3, 2016
    Publication date: May 31, 2018
    Inventors: Josée Laganière, Nellie Dumont
  • NKP30 RECEPTOR TARGETED THERAPEUTICS
    Publication number: 20180147240
    Abstract: The invention is directed to T cells and other cells that express chimeric NK-p30 receptors (“chimeric NKp30 T cells”), methods of making and using chimeric NKp30 T cells, and methods of using these chimeric NKp30 T cells, isolated populations thereof, and compositions comprising the same. In another aspect, said chimeric NKp30 T cells are further designed to express a functional non-TCR receptor. The disclosure also pertains to methods of making said chimeric NKp30 T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said chimeric NKp30 T cells, populations thereof, or compositions comprising the same.
    Type: Application
    Filed: December 4, 2017
    Publication date: May 31, 2018
    Inventors: Tong ZHANG, Charles L. Sentman
  • Compositions and Methods for Treatment of Cardiovascular Disorders
    Publication number: 20180147241
    Abstract: Methods for treating cardiovascular disorders that include administration of an ECM based composition to damaged cardiovascular tissue in conjunction with a treatment remedy, such as ventricular assistance and transmyocardial revascularization (TMR), which induces enhanced bioremodeling of the damaged cardiovascular tissue and regeneration of new cardiovascular tissue and associated structures with site-specific structural and functional properties.
    Type: Application
    Filed: January 23, 2018
    Publication date: May 31, 2018
    Inventor: Robert G Matheny
  • HEPATOCYTES AND HEPATIC NON-PARENCHYMAL CELLS, AND METHODS FOR PREPARATION THEREOF
    Publication number: 20180147242
    Abstract: The present invention pertains to hepatocytes, liver progenitor cells, cholangiocytes, liver sinusoidal endothelial progenitor cells, liver sinusoidal endothelial cells, hepatic stellate progenitor cells, hepatic stellate cells, and liver cellular tissue models, as well as to methods for preparing these cells. The present invention also pertains to a cell fraction comprising liver progenitor cells, liver sinusoidal endothelial progenitor cells, or hepatic stellate progenitor cells. The present invention also pertains to a pharmaceutical composition or kit comprising the above-mentioned cells, a liver cellular tissue model, or a cell fraction.
    Type: Application
    Filed: March 16, 2016
    Publication date: May 31, 2018
    Applicant: The University of Tokyo
    Inventors: Atsushi Miyajima, Taketomo Kido, Yuta Koui, Ayaka Kobayashi
  • AMYLOID BETA FIBRIL DECOMPOSING AGENT, AND THERAPEUTIC OR PREVENTIVE AGENT AND THERAPEUTIC OR PREVENTIVE FOOD COMPOSITION FOR DISEASES CAUSED BY AMYLOID BETA FIBRIL FORMATION
    Publication number: 20180147243
    Abstract: An object of the present invention is to provide: an amyloid ? fibril decomposing agent containing a natural product as an active ingredient; a therapeutic or preventive agent for a disease caused by amyloid ? fibril formation; and a therapeutic or preventive food composition for a disease caused by amyloid ? fibril formation. Provided are: an amyloid ? fibril decomposing agent containing a dry powder, ground product and/or extract of an earthworm as an active ingredient; a therapeutic or preventive agent for a disease caused by amyloid ? fibril formation; and a therapeutic or preventive food composition for a disease caused by amyloid ? fibril formation. The disease caused by amyloid ? fibril formation is preferably Alzheimer's disease.
    Type: Application
    Filed: July 14, 2016
    Publication date: May 31, 2018
    Applicant: WELL STONE CO.
    Inventors: Yoichi ISHII, Takeshi OKAMOTO, Sayaka ISHII
  • HONEY FRACTION
    Publication number: 20180147244
    Abstract: The present invention provides a honey fraction obtainable by a method comprising (a) obtaining an absorbed component by causing honey to be brought into contact with an adsorbent, (b) obtaining an organic solvent fraction by eluting the absorbed component with an organic solvent that is acetone, ethyl acetate, or ethanol, and (c) obtaining a honey fraction from the organic solvent fraction.
    Type: Application
    Filed: May 19, 2016
    Publication date: May 31, 2018
    Inventors: Yoichiro ISOHAMA, Ichiro HORIE, Hiroko TANI, Yuka KIMURA, Maiko YOSHIMATSU, Tae NAKATSUKA
  • SELECTIVE CELL TARGETING USING ADENOVIRUS AND CHEMICAL DIMERS
    Publication number: 20180147245
    Abstract: Compositions and methods for retargeting adenovirus to a cell using chemical dimers are described. In particular, a recombinant adenovirus comprising a nucleic acid comprising a capsid-dimerizing agent binder conjugate and a ligand-dimerizing agent binder conjugate is provided.
    Type: Application
    Filed: January 23, 2018
    Publication date: May 31, 2018
    Applicant: Salk Institute for Biological Studies
    Inventors: Clodagh O'Shea, Shigeki Miyake-Stoner, Colin Powers
  • Substantially Testosterone Free Compositions
    Publication number: 20180147246
    Abstract: 1.
    Type: Application
    Filed: November 30, 2016
    Publication date: May 31, 2018
    Inventor: Margaret Gardiner-Hunt
  • METHOD FOR PREPARATION OF A CANNABINOID EXTRACT FROM HEMP
    Publication number: 20180147247
    Abstract: The invention relates to a method for extraction and separation of cannabinoids from industrial hemp, designed for medicinal purposes, and also the preparation of an extract, not containing tetrahydrocannabinol, and the preparation of maximum refined individual cannabinoids. The advantage of the method according to the invention consists in the preparation of an extract from hemp, which contains at a high percentage medically useful cannabinoids and doesn't contain undesirable admixtures and tetrahydrocannabinol, so that it can be used without any restrictions as a pharmaceutical. Moreover, the method allows the possibility of separation, if required, into individual useful cannabinoids as pure compounds, in ecological terms, without environmental pollution, as it is according to the most synthetic methods.
    Type: Application
    Filed: May 19, 2016
    Publication date: May 31, 2018
    Applicant: "POBELCH - GLE" OOD
    Inventor: Ervin Milenov IVANOV
  • METHOD FOR PREPARING BROCCOLI PROTEIN PEPTIDE, BROCCOLI PROTEIN PEPTIDE PREPARED THEREFROM AND USE THEREOF
    Publication number: 20180147248
    Abstract: Provided is a method for preparing a broccoli protein peptide. The method uses a broccoli protein as the raw material, and obtains a broccoli protein peptide powder through the steps of preprocessing, enzymatic hydrolysis, terminating enzymatic hydrolysis, separation, and drying and the like. Also provided is the use of the prepared broccoli protein peptide in resisting oxidation, reducing cholesterol and lowering blood lipids.
    Type: Application
    Filed: May 3, 2016
    Publication date: May 31, 2018
    Inventors: Jidong WANG, Huan QI, Xiaohe ZHENG, Hui ZHANG, Yongdong WANG, Hailing TANG, Haiming LIN
  • PHARMACEUTICAL COMPOSITION FOR TREATING ECZEMA AND METHOD FOR PREPARATION THEREOF
    Publication number: 20180147249
    Abstract: A pharmaceutical composition for treating eczema is disclosed. The pharmaceutical composition includes, by weight, 2 to 6 parts of Dried Rhizoma Zingiberis Officinalis, 2 to 6 parts of Paeonia Lactiflora, 1 to 4 parts of Fructus Amomi, 0.5 to 3 parts of Semen Alpiniae Katsumadai, 0.5 to 3 parts of Inula helenium, 0.5 to 3 parts of Radix Et Rhizoma Rhei and 0.5 to 3 parts of Rhizoma Dioscoreae. The components of the pharmaceutical composition synergistically cooperate to clear and disinhibit the liver and gallbladder and clear away damp heat from the body. The pharmaceutical composition can be used to treat skin eczema symptoms caused by metabolic disorders of the liver and gallbladder functions. A method for preparing the pharmaceutical composition is also disclosed.
    Type: Application
    Filed: November 29, 2017
    Publication date: May 31, 2018
    Inventor: Luping YU
  • SYNTHETIC SUBSTRATES FOR ENZYMES THAT CATALYZE REACTIONS OF MODIFIED CYSTEINES AND RELATED METHODS
    Publication number: 20180147250
    Abstract: Synthetic probes for detecting the activity of enzymes that catalyze reactions of post-translationally modified cysteine residues are described. The probes include “turn-on” probes that include a carbamate linkage that is cleaved via an intramolecular reaction with a free thiol produced by an enzyme catalyzed activity. The probes also include ratiometric, Michael addition-based probes that respond to enzymatic activity by a change in structure that results in a change in fluorescence properties. Methods of using the probes to detect enzymatic activity and disease are described. For example, the probes can be used to detect enzymatic activity in a variety of samples, including live cells and heterogeneous tissues. In addition, prodrugs that can be activated by enzymes that catalyze reactions of post-translationally modified cysteine residues and methods of using the prodrugs to treat disease are described.
    Type: Application
    Filed: November 30, 2017
    Publication date: May 31, 2018
    Inventors: Bryan C. Dickinson, Rahul S. Kathayat, Michael W. Beck
  • METHODS AND COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF BARTH SYNDROME
    Publication number: 20180147251
    Abstract: The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.
    Type: Application
    Filed: June 19, 2017
    Publication date: May 31, 2018
    Inventors: D. Travis Wilson, Mark Bamberger
  • INHIBITORS OF MITOCHONDRIAL FISSION AND METHODS OF USE THEREOF
    Publication number: 20180147252
    Abstract: The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present disclosure provides methods of reducing abnormal mitochondrial fission in a cell. Also provided are methods for designing and validating mitochondrial fission inhibitor constructs and peptides, including but not limited to, evaluating the effects of the constructs and peptides on binding of dynamin-1-related protein (Drp1) GTPase activity, Drp1 to mitochondrial fission 1 protein (Fis1), reduction of mitochondrial damage, reduction in cell death, inhibition of mitochondrial fragmentation in a cell under pathological conditions, and reduced loss of neurites in primary dopaminergic neurons in a Parkinsonism cell culture.
    Type: Application
    Filed: January 4, 2018
    Publication date: May 31, 2018
    Inventors: Daria Mochly-Rosen, Xin Qi, Nir Qvit
  • Treatment of Constipation-Predominant Irritable Bowel Syndrome
    Publication number: 20180147253
    Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.
    Type: Application
    Filed: January 25, 2018
    Publication date: May 31, 2018
    Inventors: Jeffrey Johnston, Bernard Joseph Lavins, Harvey Schneier
  • COMPOSITIONS COMPRISING CYCLOSPORIN
    Publication number: 20180147254
    Abstract: The present invention relates to a formulation comprising a pharmaceutically active ingredient and a coating. The invention also relates to the use of the formulation in the treatment and prevention of disorders of the gastrointestinal tract. Also disclosed are methods for preparing the formulations.
    Type: Application
    Filed: November 6, 2015
    Publication date: May 31, 2018
    Applicant: Sigmoid Pharma Limited
    Inventors: Ivan Coulter, Vincenzo Aversa, Mónica Torres Rosa, Dáire O'Donnell, Wyatt Renaud of Calhane
  • INTRACELLULAR PH-RESPONSIVE FUSION PEPTIDE AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL PROTEIN AGGREGATION OR MISFOLDING CONTAINING THE SAME AS ACTIVE INGREDIENT
    Publication number: 20180147255
    Abstract: A pH-responsive fusion peptide according to the present disclosure, containing a cell-penetrating peptide exhibiting a positive charge, which contains 2-15 arginine residues, and a ?-sheet-forming segment, experiences structural change depending on pH change. Due to the structural change, the anti-prion activity and cytotoxicity of the fusion peptide can be controlled as desired.
    Type: Application
    Filed: November 30, 2017
    Publication date: May 31, 2018
    Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY, INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS
    Inventors: Yong beom LIM, Chong suk Ryou
  • MEANS AND METHODS FOR TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY (FSHD).
    Publication number: 20180147256
    Abstract: The invention is related to facioscapulohumeral muscular dystrophy (FSHD) and in particular therapeutic means and methods for the treatment of the disease. In one aspect the invention provides a composition for use in the treatment of a subject that has FSHD which composition has a therapeutically effective amount of a substance which increases the level and/or activity of a protein encoded by a structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) gene in cells of the subject. The invention also provides means and methods for typing FSHD.
    Type: Application
    Filed: June 2, 2016
    Publication date: May 31, 2018
    Inventors: Silvere Maria VAN DER MAAREL, Richard Joannes Leonardus Franciscus LEMMERS, Judit BALOG, Stephen Justice TAPSCOTT, Alrabi TAWIL
  • BTN3A ECTODOMAIN PROTEINS AND METHODS OF USE
    Publication number: 20180147257
    Abstract: BTN3A ectodomain polypeptides are provided, which comprise a BTN3A ectodomain (e.g., a BTN3A1, BTN3A2, or BTN3A3 ectodomain) and lack a BTN3A transmembrane domain (e.g., a BTN3A1, BTN3A2, or BTN3A3 transmembrane domain). Compositions and methods are provided for activating an antigen presenting cell (APC). In some cases, the APC is activated in vivo. For example, in some cases, APC activity is stimulated (an APC is activated) in a mammal by administering a pharmaceutical composition comprising a BTN3A ectodomain polypeptide.
    Type: Application
    Filed: May 20, 2016
    Publication date: May 31, 2018
    Inventors: Daniel Mark Corey, Aaron Michael Ring, Irving L. Weissman
  • RECOMBINANT FUSION PROTEIN FORMULATION
    Publication number: 20180147258
    Abstract: Provided is a liquid formulation that enables the stable storage of recombinant fusion proteins, comprising a recombinant fusion protein, a buffer salt, a stabilizer, and a surfactant.
    Type: Application
    Filed: September 25, 2015
    Publication date: May 31, 2018
    Inventors: Yinjue Wang, Junfeng Li, Xiaole Huang