Abstract: A filter structure for a syringe comprises a filter unit installed within a cylinder and connected to a needle coupled to the front of the cylinder-in order to perform filtering when an injection solution introduced into the cylinder through the rear thereof is discharged through the needle, wherein a second fluid passage is formed outside a first fluid passage, and the filter unit comprises: a first check valve that is connected with the needle and blocks the second fluid passage; a second check valve that blocks the first fluid passage; a filter member installed on the second fluid passage; and a filter body located between the first check valve and the filter member and coupled to the first check valve at the front thereof and to the second check valve at the rear thereof.

Abstract: The disclosure relates to a drug delivery device comprising: a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament from the medicament container, at least one feedback mechanism that is in operative connection with the plunger, the feedback mechanism comprising a collar, a control spring biasing the collar in a distal direction, a needle shroud, operatively axially abutting the collar in a first coupled state and prevented from axially decoupling the collar by the plunger in its proximal position, wherein the plunger, when approaching the distal position during movement from the proximal position towards the distal position, is adapted to allow axial decoupling of the needle shroud from the collar, thus allowing for a limited axial movement of the collar relative to the needle shroud until the collar axially abuts the needle shroud in a second coupled state.

Abstract: A syringe plunger, bung and/or syringe is disclosed. The syringe plunger includes an elongate shaft for insertion into a barrel of a syringe, wherein an end of the shaft is configured for slidable engagement within a recess in a bung of the syringe such that the end of the shaft abuts a surface of the recess, and wherein the end of the shaft is further configured such that, after engagement between the end of the shaft and the recess, a relative force therebetween longitudinally deforms the bung.

Abstract: The present invention provides a device (1) for monitoring the application of a drug to a patient by means of a drug pen (100), whereby the drug pen comprises a front end provided with an injection needle and a rear end provided with an actuation pushbutton, the device comprising a body (2) which can be dismountably coupled to the pen; an injection detection means determining when a drug injection is carried out; and a processing means configured for storing the date and time of the injection when the injection detection means detects that a drug injection is carried out, whereby the body is configured to be coupled to the pushbutton of the pen such that the pushbutton is actuated by pushing directly on the body, whereby the injection detection means is implemented as actuation detector configured for detecting said pushing action.

Abstract: The invention relates to a medical injection device having a polymeric housing or housing parts. The housing comprises a moulded outer housing element and a moulded elongated tubular inner housing element. The elongated tubular inner housing element is formed as one unitary element and carries a pointer and one or more projections in predetermined and correlated positions. The pointer points to indicia on a scale drum and the projections engage the scale drum. The outer housing element is moulded over the elongated tubular inner housing element in a 2K moulding to form one single housing component.

Abstract: The present invention provides a drug delivery device comprising a housing (2) extending along a longitudinal axis, a dose dial member (3) being rotatable relative to the housing (2) to set a dose of drug to be expelled from an attached reservoir and comprising a first serrated transversal surface (7), a second serrated transversal surface (16) being axially and rotationally fixed with respect to the housing (2), and being configured for slipping engagement with the first serrated transversal surface (7) in a bi-directional ratchet interface in response to the dose dial member (3) being rotated relative to the housing (2) to increase or decrease the dose, and a dose delivery mechanism for expelling a set dose, the dose delivery mechanism comprising a piston rod (50), a torsion spring (30) for providing energy to drive the piston rod (50), an activation button (8) being axially movable relative to the housing (2) between an inactivated position in which the torsion spring (30) is retained and an activated posi

Abstract: An insulin injection needle with needle tip protection has a needle body, needle base, main cover and outer sheath. The main cover is provided with the trigger tube, front casing and spring. The trigger tube is used to protect the injection section of needle body before use and the front casing is used to protect the injection section of needle body after use. Before use, the trigger tube extends out of the main cover and is in the state of protecting the needle, and the front casing is in the main cover; after, the trigger tube is in the main cover and the front casing extends out of the main cover and protects the needle. The unlocking of trigger tube and front casing correlate with injection readiness and the tail cover and needle base trigger the unlocking of trigger tube and front casing during the installation.

Abstract: The invention relates to a method for producing pre-filled cemented needle syringes, comprising the following steps: a device (D) for protecting the needle onto syringe bodies (2), the device comprising an external sleeve which can move along a longitudinal axis between a forward position in which it covers the needle, and a retracted position in which it does not cover the needle, means for returning the sleeve to the forward position, and a needle protector; arranging the syringe bodies (2), which are provided with the protective device, in recesses (O204) provided in a holder (200); placing the holder (200) in a container (100) for transport; removing the holder from the container; filling each syringe body with an active principle; inserting a plunger into each syringe; and removing the syringes (1) from their holder for the purpose of inspection and labelling.

Abstract: A safety syringe has a barrel, a pushing element, a retracting element, and a needle group. The barrel is hollow and has a needle-group mounting end, an operating grip end, and a barrel lumen. The pushing element is retractably mounted in the barrel lumen and has a pushrod chamber. The retracting element is airtightly and slidably mounted in the pushrod chamber. The needle group is connected to the needle-group mounting end of the barrel. The present invention can pull the retracting element to move relative to the pushing element to form a low pressure condition in the pushrod chamber as a vacuum status. After the injection, a vacuum attraction force in the pushrod chamber can retract the used needle group into the pushrod chamber for safe use of the safety syringe.

Abstract: Presented herein are a system for heating fluid, which, in certain embodiment, comprises a fluid separator, a conduit, and a plurality of inductors. The system demonstrates a single flow path without compromising advantages of the existing blood warmers, such that the heat exchanger would not experience stagnant flow that may cause overheating of a local flow path.

Abstract: Presented herein is an infusate heating system with a vacuum release valve that obviates a system halt failure due to inaccurate detection of fluid level in an infusate reservoir.

Abstract: Presented herein are various systems, methods, and apparatuses for heating infusate by an induction heater e.g., an electromagnetic heater, and storing thermal energy in a reservoir of thusly heated infusate. In certain embodiments, a system includes a reservoir for containing an infusate, a fluid heater, a diversion valve, a patient line, and a recirculation line.

Abstract: A device for adding a flavor and/or cough suppressant component to an inhaler is described. The device includes a housing having an interior chamber, wherein the housing includes at least one air inlet and at least one air outlet connected to the interior chamber, thereby forming an airflow pathway through the interior chamber, and at least one flavoring and/or cough suppressant component positioned within the interior chamber, wherein the housing is attachable to an exterior surface of an inhaler having at least one air inlet, such that the at least one air outlet of the device aligns with the at least one air inlet of the inhaler to form an airflow path through the device and into the inhaler.

Abstract: An aerosol medication delivery system includes a holding chamber having an output end with a plurality of tabs extending from an exterior. A patient interface includes a housing having an annular attachment collar configured with a plurality of openings receiving the plurality of tabs. The housing has a plurality of engagement members formed on an interior of the housing and an interior wall defining a sealing surface. A retaining ring is engaged by the engagement members and is coupled to an interior of the housing. A one-way inhalation valve includes a non-moveable annular valve seat engaged by the retaining ring and the sealing surface of the interior wall. A one-way exhalation valve is formed separately from the one-way inhalation valve, and is coupled to the patient interface.

Abstract: A pressure regulating device includes a housing having a gases inlet adapted to in use be in fluid communication or integrated with a breathing assistance apparatus which conveys gases to an infant or a neonate requiring breathing assistance, an outlet adapted to be in use in fluid communication with said infant, and an aperture which enables the venting of a portion of gases that in use are passing through the housing from the inlet to the outlet. A tube inlet on the housing is adapted to receive a surfactant delivery device therethrough to enable administration of surfactant to the infant or neonate. A sealing mechanism seals around the surfactant delivery device and is adapted to normally fluidically seal the tube inlet and in use allow the surfactant delivery device to pass through the tube inlet.

Abstract: A holder apparatus for holding a conduit and/or patient interface such as a cannula, has a mount 251 to couple with a breathing assistance apparatus 10 and at least one mechanical feature 237a, 237b for holding the conduit and/or patient interface such as a cannula in place relative to the breathing assistance apparatus.

Abstract: Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter measuring characteristics of the airflows. A user may provide a controller with patient size information via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. If the measured airflow characteristics fall outside an acceptable range, the controller may cause a sensory alarm to alert the user. The device may work within a network of devices and user interfaces. The device may include a variety of sensors including pressure, CO2, O2, and temperature sensors. If the measurements of these sensors fall outside an acceptable range, the controller may cause a sensory alarm to alert the user.

Abstract: A method of providing pressure support to a patient that includes determining a measure associated with an inspiratory time of the patient during therapy, delivering a flow of breathing gas to the patient at an inspiratory positive airway pressure (IPAP) level during at least a portion of an inspiratory phase of the patient, delivering the flow of breathing gas to the patient at an expiratory positive airway pressure (EPAP) level that is less than the IPAP level during at least a portion of an expiratory phase of the patient, and automatically setting a rise time associated with a transition from the EPAP level to the IPAP level based on the measure associated with the inspiratory time of the patient. Also provided is a pressure support system adapted to perform the method.

Abstract: Devices and methods for delivering air to a patient are provided. A device includes a first portion having a first airflow inlet and a first impeller configured to move in response to airflow from the first airflow inlet contacting the first impeller, the first portion defining a first airflow path; a second portion having a second airflow inlet, a second impeller, and an outlet for communicating airflow to a patient, the second portion defining a second airflow path; and means for coupling the first portion and the second portion, such that movement of the first impeller causes corresponding movement of the second impeller, wherein the second impeller is configured to impel air through the second airflow inlet and out of the outlet to the patient, upon movement of the second impeller and wherein the first and second airflow paths are not in fluid communication.

Abstract: A respiratory assistance apparatus (1) for delivering a flow of gas to a patient (P) comprises a gas delivery conduit (2) for conveying a flow of gas, measuring means (6) designed to measure at least one parameter representative of the flow of gas and to supply at least one signal corresponding to said parameter, signal-processing means (8) designed to process said signal coming from the measuring means and to deduce from said signal at least one item of information relating to performance and/or discontinued performance of chest contractions (CT), calculating means designed to calculate at least one duration of discontinuation or absence of chest contractions (tNCT), and storage means (12) configured to register said duration of discontinuation or absence of chest contractions.

Abstract: A tracheal tube attachment for a tracheal device is disclosed. The tracheal tube attachment includes a tube and a plate. The tube includes a proximal section having an open proximal end for attaching to a tracheal device, and a distal section having an open distal end. The proximal section extends from the proximal end to an intermediate point between the proximal and distal ends. The distal section is integrally connected to the proximal section at the intermediate point, where it has the same diameter as the proximal section, and further extends to the distal end with an increasing diameter towards the distal end. The proximal end is integrally connected to the center of the plate, which has a circular hole in its center so that the plate would not block the opening of the tube at the proximal end. The tracheal tube attachment enables a person wearing a tracheal device to breathe comfortably by preventing water and other unwanted materials from getting into the tracheal device.

Abstract: A surgical instrument system for use in a surgical procedure is disclosed. The surgical instrument system may include an instrument configured to puncture the tissue of a patient and detect when the instrument has entered a lumen of the patient's body. The surgical instrument system may include a balloon catheter including a percutaneous dilation balloon and a moveably positionable retainer. The retainer is configured to move relative to the balloon such that upon inflation of the balloon when the balloon is positioned in the opening in the patient's tissue, the retainer engages the patient's tissue to inhibit movement of the balloon catheter.

Abstract: An endotracheal tube has a tip. An endotracheal intubation system has a first camera, a blade, a second camera, and a display. The blade has a camera accommodation, a passage, and a guiding portion. The first camera is situated in the camera accommodation for capturing a first image. The passage has a side surface and a top surface. The guiding portion is the junction of the side surface and the top surface. The second camera is for capturing an image of the guiding portion when the endotracheal tube moves along the passage and is situated within the endotracheal tube. The display is electrically connected with the first camera and the second camera for displaying the first image and the image of the guiding portion to ensure that the tip of the endotracheal tube moves along the guiding portion when the endotracheal tube moves along the passage.

Abstract: A patient interface device is for a pressure support system that includes a flow generator that produces a flow of breathing gas to be delivered to an airway of a patient. The patient interface device includes a sealing element to engage a face of the patient and receive the flow of breathing gas; a lumen having a first end and a second end opposite and distal the first end, the first end being in fluid communication with an interior of the sealing element; a connector member coupled to the second end of the lumen; a pressure sensor coupled to the connector member, the pressure sensor sensing pressure of a gas exiting the second end of the lumen; and a surface provided on one of the lumen and the connector member, the surface defining a thru hole through which undesirable liquid in the lumen can escape.

Abstract: The present invention relates to an arrangement (1) comprising a switchable connection (2) and a gas flow reversing element (3), e.g.

Abstract: The present invention relates to a method for controlling the gas temperature in medical devices by means of a state observer, e.g., in the field of laparoscopy or respiration, and to devices for carrying-out said method.

Abstract: An air delivery system includes an air flow generator to provide a pressurized flow of air, a patient interface to provide a seal with the patient's face in use, an air delivery conduit to interconnect the air flow generator and the patient interface, and a controllable vent valve to control venting from the patient interface. The vent valve is controlled to maintain a substantially constant air flow in the air delivery conduit and the air flow generator.

Abstract: A light-irradiating apparatus which emits light for activating a body is provided. The light-irradiating apparatus includes a blue light source, a white light source, and a controller. The controller controls the white light source and the blue light source, and adjusts irradiation intensities of light emitted by the blue light source and the white light source. The controller causes the white light source to continuously maintain an on state and causes the blue light source to repeat an on state and an off state. The controller causes a sum of the irradiation intensity of the light which is emitted by the white light source and the irradiation intensity of the light which is emitted by the blue light source to be greater than or equal to a biological effect threshold at which light produces an effect of activating the body.

Abstract: A catheter includes an elongated tube having a distal portion having a distal end and a sidewall defining at least one drainage lumen. The sidewall includes a drainage portion which allows fluid to pass through the sidewall and into the drainage lumen. The catheter also includes a permeable tissue support. The tissue support is configured to be deployed in the urinary tract to maintain the distal end of the elongated tube at a predetermined position in a bladder, a ureter, a renal pelvis, or a kidney of the patient. When deployed, the permeable tissue support defines a three-dimensional shape of sufficient size to permit flow of at least a portion of fluid from the urinary tract through the tissue support and drainage portion of the elongated tube to the at least one drainage lumen.

Abstract: A ureteral catheter for placement in a kidney, renal pelvis, and/or in a ureter adjacent to the renal pelvis of a patient, includes: an elongated tube having a proximal end, a distal end, and a sidewall extending between the proximal end and the distal end of the tube defining at least one drainage lumen extending through the tube; and an expandable retention portion configured to transition from a retracted position to a deployed position and which, in the deployed position, defines a three-dimensional shape positioned to maintain fluid flow from the kidney through at least the distal end of the tube.

Abstract: The present invention relates to a single-lumen vascular catheter (1) to be inserted into a blood flow channel for the injection of a product by the venous or arterial route, comprising a tube (2) having a hollow longitudinal body with a lumen (3), the lumen (3) extending along the full length of the tube (2) and being intended to permit the injection of a given volume (4) of product at a prescribed flow rate the tube (2) having lateral orifices (5) which are of substantially identical size and are arranged in the longitudinal body substantially symmetrically about the longitudinal axis, near a distal end (6) of the tube (2), an end surface (7) at the distal end (6) of the tube (2) reducing a total surface area of the lumen (3) starting from the distal end (6) of the tube (2).

Abstract: A catheter is provided including a first lumen and a second lumen. A first member is disposed for relative movement within the first lumen and defines a cavity, A second member is disposed for relative movement within the second lumen. The cavity of the first member is configured for disposal of the second member. The catheter may include an elongated tubular body that includes the first lumen and the second lumen. The first member may have a distal portion that extends beyond the distal end of the body. The distal portion may include the cavity. The cavity may be defined by a member lumen. The first and second members may include tubular stylettes. The second member may include a guidewire.

Abstract: Systems and methods for securely supporting devices such as reservoirs for surgical drains or catheters. In one embodiment, a surgical drain support apparatus comprises a sash having a first end and a second end. The sash has an opening such as a slit or a loop at the second end. When the first end is inserted through the opening, the sash forms an adjustable loop that is placed around a user's body (e.g., over the shoulder or around the waist), thereby supporting the apparatus on the user's body. The first end of the sash, which hangs downward from the large loop, has one or more compartments that hold surgical drain reservoirs. The first end of the sash also has a strap attached to it that can be wrapped around the user's body (e.g., around the leg) to hold the first end of the sash against the user's body.

Abstract: Improved methods for percutaneously creating, entering and/or dilating an opening in the wall of a blood vessel or other anatomic structure. The improvement comprises deploying a guide element having a proximal segment and a distal segment, the diameter of said distal segment being greater than the diameter of said proximal segment at their juncture, and which at said juncture forms an abrupt circumferential step comprising a proximally-facing surface. Said proximally-facing surface abuts the catheter's tip and shields said tip, thereby facilitating passage of said catheter as it enters and passes through said opening in said wall of a blood vessel or other anatomic structure.

Abstract: A device for restraining a guide wire includes a base having a recessed formation configured to receive a portion of the guide wire, and a flexible lid configured to fit on the base. The lid has a main sheet portion covering the portion of the guide wire and a plurality of fingers separated by gaps and extending downwardly from a peripheral edge of the main sheet portion to surround the base. Sandwiched between the lid and base, the guide wire extends through gaps between the finger members. Constructed of sheet material, the lid is flexibly movable between a closed configuration wherein the fingers are flexed inwardly engaging the base, and an open configuration wherein the fingers are flexed outwardly releasing the base.

Abstract: A balloon catheter includes a first balloon positioned inside of a second balloon, both of which are mounted about a catheter and fluidly connected to respective inflation lumens. In a first inflated configuration, the second balloon is inflated and has a shape that includes a plurality of bulb segments, with each two consecutive bulb segments being separated by a waist hoop. In a second inflated configuration both the inner and outer balloons are inflated, and the inner balloon bears radially outwardly against the waist hoop of the outer balloon such that the waist hoop of the outer balloon has a larger diameter in the second inflated configuration than in the first inflated configuration. The bulb segment separated by waist hoops enable the balloon catheter to conform to curved passageways, such as during the implementation of a stent.

Abstract: Disclosed is a sinus balloon catheter. The sinus balloon catheter includes a body unit, a bending angle adjusting unit that includes a bending angle adjusting lever and a rotary plate, and a guide unit that includes a balloon, and has a pair of bending angle adjusting wires therein. The guide unit includes a first guide body, and a second guide body that is slidably provided in the first guide body, the balloon is provided on the second guide body, the rotary plate is connected to any one of the pair of bending angle adjusting wires to be rotated, and the other bending angle adjusting wire is maintained within the guide unit, and the guide unit is inserted into any one of a sphenoidal sinus, a frontal sinus, and a maxillary sinus.

Abstract: A balloon catheter has a first shaft that includes a first lumen, and that extends in an axial direction, a first balloon disposed on a distal side of the first shaft, and capable of being expanded and contracted in a radial direction, a second shaft that includes a second lumen, and that extends in the axial direction, and a second balloon disposed on a distal side of the second shaft so as to cover an outer periphery of the first balloon, and that is capable of being expanded and contracted in the radial direction. The first shaft is configured to be movable in the axial direction relative to the second shaft, and the first balloon is configured to be movable in the axial direction relative to the second balloon in response to movement of the first shaft.

Abstract: An applicator assembly includes at least one ampoule formed of a frangible material and containing liquid to be applied, a body having a proximal end, a distal end, and an interior portion defining a chamber adapted to receive the at least one ampoule, an application member attached to the distal end of the body, an actuator projecting from the body operable to fracture the at least one ampoule, a trench formed in a surface of the body, and a vent disposed through a surface of the trench.

Abstract: An applicator assembly includes a plurality of ampoules formed of a frangible material and containing liquid to be applied, a container having a proximal end, a distal end, and an interior portion defining a chamber adapted to receive the plurality of ampoules, an application member attached to the distal end of the container; and at least one actuator projecting from the container, wherein the at least one actuator is actuatable to independently fracture the plurality of ampoules, thereby independently releasing the liquid into the application member. The at least one actuator may be moveable from a first position to a second position, the applicator having a smaller profile when the actuator is in the second position than when the actuator is in the first position.

Abstract: The method of producing a transdermal absorption sheet includes, in this order, a filtration step of carrying out sterile filtration on a base liquid, a base liquid feeding step of feeding the base liquid to a surface of a mold having needle-like recessed portions, tip ends of which are filled with a drug solution, while leaving a space between the drug solution and the base liquid, a drying step of drying the drug solution and the base liquid, and a peeling-off step of peeling off a formed transdermal absorption sheet in which an average concentration of solid contents of the base liquid in the drying step is increased by 5% by weight or more from an average concentration in the base liquid feeding step, and then in a state in which the average concentration is 75% by weight or less, the base liquid is moved into the needle-like recessed portions.

Abstract: The method for automatically producing precise tattoo markings on any anatomical body portion automatically by providing a controlled articulated arm carrying a tattoo machine implement. The method also provides a multi-axis positioning platform for supporting and positioning a person, receiving a tattoo, in a prime, optimal, and comfortable position. Also, the method provides choosing, with a selector, a tattoo of choice from any data source of images, as well as applying, rectifying, and mapping, with a physical or virtual design projection and visualization media, the chosen tattoo to the person. The method completes a tattoo using the articulated arm with the tattoo machine implement producing a precise, accurate, and aesthetically pleasing tattoo, automatically.

Abstract: A connector which couples to an outlet conduit to decrease an outlet conduit passageway pressure differential between outlet conduit opposing first and second ends, whereby the connector includes a mixing chamber having a first inlet port in fluidic communication with a connector first open end and the mixing chamber; an outlet port in fluidic communication with the mixing chamber and a connector second open end; and a second inlet port in fluidic communication with the connector second open end and the mixing chamber. Additionally, a connector including a connector internal surface defining a connector passageway which communicates between connector first and second open ends; and a sensor module operatively coupled to the connector passageway to sense a parameter of a first fluid flowing in a first fluid flow path through the connector passageway.

Abstract: An electrode system includes a gel deployment receptacle configured to release a conductive gel onto a body of a subject and a fluid pump in fluid communication with the gel deployment receptacle.

Abstract: This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 1 nanosecond at the full-width-half-maximum. This treatment may prevent at least growth of the lesion.

Abstract: An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.

Abstract: In one aspect the invention provides a surgical implant conductor formed from a length of conductive material which exhibits increased radio frequency alternating current resistance. This conductive material defines an exterior surface where at least a portion of the exterior surface of the conductor defines a region with a roughened surface. Preferably the roughening of the exterior surface increases the area of the exterior surface when compared to a non-roughened surface, resulting in a reduction in the effective cross-section area of the conductor used to transport alternating currents.

Abstract: An implantable electrical lead suitable for left sided cardiac placement, the implantable medical electrical lead having an external blood contacting surface having an external coating including a monolayer of at least one biological agent that promotes endothelialization covalently attached to a polymeric lead surface.

Abstract: A stimulation lead includes a lead body; terminals disposed along the proximal end portion of the lead body; electrodes disposed along the distal end portion of the lead body, the electrodes including segmented electrodes. Each of the segmented electrodes includes a base and at least one finned arrangement radially extending from the base. Each of the finned arrangement includes elongated segments, each of the elongated segments extending along at least 50% of a length of a dimension of the base. Each finned arrangement also includes curved segments, where a first curved segment connects a first end portion of a first elongated segment to a first end portion of an intermediate elongated segment and a second curved segment connects a second end portion of a second elongated segment to a second end portion of an intermediate elongated segment. The lead also includes conductors electrically coupling the terminals to the electrodes.

Abstract: Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.