Abstract: Methods, systems, and computer readable media for transoral lung access. In some examples, the system includes a bronchoscope, a concentric tube probe deployable from within the bronchoscope, and a steerable needle nested deployable from within the concentric tube probe. The system can include a control system for deploying the concentric tube probe from the bronchoscope into a lung to a location where a target is within a range of the steerable needle and for deploying the steerable needle from the location to the target.

Abstract: A surgical robotic system automatically calibrates tubular and flexible surgical tools such as endoscopes. By compensating for unideal behavior of a surgical instrument, the surgical robotic system can accurately model motions of the surgical instrument and navigate the surgical instrument while performing a surgical procedure on a patient. During calibration, the surgical robotic system moves the surgical instrument to a target position and receives data describing an actual position and/or orientation of the surgical instrument. The surgical robotic system determines gain values based at least on the discrepancy between the target position and the actual position. The surgical instrument can include tubular components referred to as a sheath and leader. An instrument device manipulator of the surgical robotic system actuates pull wires coupled to the sheath and/or the leader, which causes the surgical instrument to articulate.

Abstract: A system and method for enhancing diagnosis and treatment including an extended working channel defining an elongated passageway and adapted to extend through the bronchoscope and into a luminal network, an opening operably associated with the extended working channel and in fluid communication with the luminal network, and a medical instrument configured for insertion through the extended working channel, wherein during operation, apposition of tissue on the extended working channel or medical instrument isolates at least a portion of a luminal network in which the extended working channel is inserted.

Abstract: Disclosed are laryngoscopes and other devices that include both a visualization feature and a suction component, to eliminate debris and bodily fluids and secretions that may accumulate on the visualization component. The devices may include one or more of the fluid intake ports that may be sized and located proximate to the operational ends of the visual-aid components, e.g., the camera lens or LED, to maintain a clean field of view for operation of the component. The internal passageways of the device are configured, dimensioned and/or shaped to facilitate desired fluid flow characteristics, flow rate, and/or pressure rates and facilitate methods of manufacturing the device.

Abstract: A medical robotic system includes an entry guide with articulatable instruments such as surgical tools and a camera extending out of its distal end. The camera instrument is manipulatable by a camera manipulator, which has a first mechanism for pivoting a focal point of the camera instrument about a pivot of the camera instrument and a second mechanism for positioning the pivot within a three-dimensional space in response to translational commands received from one or a coupled pair of input devices. The system also includes a controller which is configured to receive sensed movement of the input devices, and cause actuation of the first mechanism in response to the sensed movement if the system is in an orientational mode and cause actuation of the second mechanism in response to the sensed movement if the system is in a translational mode.

Abstract: An endoscope may include a shaft having a longitudinal axis, a first image sensor facing a distal direction, and a second image sensor facing a lateral direction. The endoscope may further include a tubular member having a lumen, the lumen having a distal-end opening and defining a longitudinal axis through a center of the lumen. The tubular member may be movable between a first configuration and a second configuration. In the first configuration of the tubular member, the longitudinal axis of the lumen may be parallel to the longitudinal axis of the shaft. In the second configuration of the tubular member, the longitudinal axis of the lumen may extend through a lateral opening in a wall of the shaft.

Abstract: Surgical visualization systems and related methods are disclosed herein, e.g., for providing visualization during surgical procedures. Systems and methods herein can be used in a wide range of surgical procedures, including spinal surgeries such as minimally-invasive fusion or discectomy procedures. Systems and methods herein can include various features for enhancing end user experience, improving clinical outcomes, or reducing the invasiveness of a surgery. Exemplary features can include access port integration, hands-free operation, active and/or passive lens cleaning, adjustable camera depth, and many others.

Abstract: A catheter (12) has an image sensing system (S1-S5) for imaging the interior wall of a passageway in which the catheter is to be located. The catheter has a radial imaging system comprising a light source arrangement for generating a light output radially around the catheter and an image sensor for receiving the generally radial light after the light has been scattered back by the interior wall. The catheter is positioned within the passageway with a known position and orientation, for example a known angle with respect to the anterior-posterior plane along the length of the catheter, so that it is known where along the catheter length, and at which angular position around the catheter, it is close to the passageway wall. The light output has a different intensity at different radial directions and/or the catheter comprises a light transmission arrangement which gives rise to different transmission of the light output at different radial directions.

Abstract: Pixelated array optics for mode mixing may be used to homogenize different modes in an optical fiber used for surgical illumination. A pixelated phase array, such as a digital micromirror device or an LCD phase plate, may impart motion to an incident beam entering the optical fiber to generate a homogeneous illumination field from a coherent light source.

Abstract: A system and method for ophthalmic surgery in which a portion of the light reflected by the eye passes through a lens that inverts the image and a portion of the light reflected by the eye does not pass through the lens. A digital image of both light that passed through the lens (lens image) and light that has not (peripheral image) is created using an image sensor. A processing resource identifies the boundary between the lens image and peripheral image and inverts at least a portion of either the lens image or the peripheral image to produce a corrected image in which no or only a small portion of the image is inverted as compared to the eye.

Abstract: A system determines the subjective refraction properties of an eye of a test subject perceiving a natural image. The system contains a memory in which at least one natural image is stored; a display device for displaying the at least one natural image from the memory; and a lens arrangement for adjusting various light-refracting elements in an optical path between the eye of the test subject and the display device. The lens arrangement is arranged at a predefined distance from the display device. A corresponding method and the use of a natural image for refraction determination are also disclosed.

Abstract: Frequency-based mode mixing may be used to homogenize different modes in an optical fiber used for surgical illumination. A laser modulator may introduce frequency modulation to laser light to generate a homogeneous illumination field due to increased mode mixing in the optical fiber.

Abstract: A computer-implemented method detects the position of a corneal vertex of an eye from a frontal image of a head and a lateral image of the head. The front and lateral images are calibrated to one another, and the position of the corneal vertex in space is determined from the frontal image and the lateral image with a geometric position determination.

Abstract: An OCT system with a swept light source centered around 1.7 ?m for identifying atherosclerotic plaque and visualization of large lipid pool is provided. Advantages for using the 1.7 ?m swept source laser include higher contrast between lipid and normal tissue and deeper penetration of the optical signals from the 1.7 ?m swept source laser into the tissue. With deeper penetration into the tissue, more structural information from deep within the tissue is obtained. The present invention also features multimodality imaging systems that integrate additional imaging systems into the OCT system at 1.7 ?m. As an example, an integrated 1.3 ?m and 1.7 ?m OCT system is provided which simultaneously generates OCT images using both the OCT systems which are used to characterize and differentiate the types of tissue.

Abstract: Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM).

Abstract: Systems and methods are provided for detecting the flow of blood or other fluids in biological tissue by illuminating the biological tissue with two or more beams of coherent light and detecting responsively emitted light. A difference in wavelength, coherence length, beam divergence, or some other property of the beams of illumination causes the beams to preferentially scatter from, be absorbed by, or otherwise interact with respective elements of the biological tissue. Flow properties in one or more regions of the biological tissue (e.g., a region with which both beams of light preferentially interact, a region with which only one of the beams preferentially interacts) could be determined based on detected responsively emitted light from the biological tissue. Variations in speckle patterns over time and/or space, Doppler shifts, or some other properties of the detected light could be used to determine the flow properties.

Abstract: Breast monitoring systems are described including a breast sensor device having a substrate fabricated to substantially conform to one or more breasts of a subject, dynamically bendable optical fibers, and a connector; a light source configured to operably couple with the optical fibers through the connector; a photodetector configured to operably couple with the optical fibers through the connector and positioned to detect light transmission through the optical fibers; a reporting device; and a microcontroller including a microprocessor and circuitry, the circuitry including input circuitry configured to receive a first set of signals and at least one second set of signals from the photodetector; calculation circuitry configured to calculate a curvature delta value based on a comparison of the first and at least one second set of signals, and calculate a breast volume delta value from the calculated curvature delta value; and reporting circuitry.

Abstract: An acoustic wave measuring apparatus generates a characteristics information distribution of the inside of an object by using an acoustic wave propagating from the object, and includes a receiving unit that receives the acoustic wave, a first imaging unit that images a first area of the object from a first direction, and acquires an image of the first area, a second imaging unit that images a second area smaller than the first area of the object from a second direction different from the first direction, and acquires a local image, a designating unit that receives, from a user, designation of a position where the imaging is performed by the second imaging unit in the image of the first area captured by the first imaging unit.

Abstract: The methods and apparatuses (including systems and device) described herein may be used to accurately and comfortably monitor and track body temperature using a wearable device that can be positioned inside a patient's ear for measuring the patient's temperature, sleeping quality, or other vital signs. These systems and methods may also include a base station and a remote analytics unit (e.g., software, hardware or firmware, including application software that may run on a hand-held or wearable electronics device). The inter-aural device (earplug device) may record and pre-process information that may then be adaptively passed on the remote analytics unit for further processing. The earplug device may engage the remote analytics unit with to download and process the temperature measurement data from the device, to electrically charge the device and also to communicate wirelessly with a smart phone or different types of mobile devices.

Abstract: A continuous glucose monitoring system including a sensor configured to detect one or more glucose levels, a transmitter operatively coupled to the sensor, the transmitter configured to receive the detected one or more glucose levels, the transmitter further configured to transmit signals corresponding to the detected one or more glucose levels, and a receiver operatively coupled to the transmitter configured to receive transmitted signals corresponding to the detected one or more glucose levels, and methods thereof, are disclosed. In one aspect, the transmitter may be configured to transmit a current data point and at least one previous data point, the current data point and the at least one previous data point corresponding to the detected one or more glucose levels.

Abstract: Described herein is a multi-dimensional kineticardiography device (300) which comprises a sensor (320) having three accelerometer/gyroscope modules (320X, 320Y, 320Z) mounted in a support which positions it at the centre of mass of a subject whose cardiac function is to be measured. The sensor (320) outputs six degrees of freedom data as linear acceleration along and rotational or angular velocity about x-, y- and z-axes. The sensor (320) is connected to a processor (335) for transmitting the kineticardiography data obtained from the sensor (320) and the electrocardiography data to a mobile computing platform (330), via Bluetooth (350), for further processing and display. An electrocardiography data chip (370) is also present for digitising the electrocardiography data for further processing.

Abstract: A non-invasive, optical-based physiological monitoring system is disclosed. In an embodiment, the non-invasive, optical-based physiological monitoring system comprises an emitter configured to emit light into a tissue site of a living patient; a detector configured to detect the emitted light after attenuation by the tissue site and output a sensor signal responsive to the detected light; and a processor configured determine, based on the sensor signal, a first physiological parameter indicative of a level of pain of the patient.

Abstract: In some examples, an implantable medical device (IMD) comprises an electrochemical cell compartment that may define a barrier between an inside of the compartment and an outside of the compartment. The IMD may include an electrically conducting pad. The IMD may comprise an electrically conducting pin coupled to the pad. The pad may include top and bottom sides. The pin may extend from the bottom side of the pad. The pad may be positioned outside of the compartment and the pin may extend through an aperture in the compartment from inside the compartment to pad positioned outside of the electrochemical cell compartment. The IMD may include an electrically insulating material surrounding the aperture and between the bottom side of the pad and the compartment. The insulating material may insulate the pad from the barrier and form a seal between the inside of the compartment and the outside of the compartment.

Abstract: A hemodynamic monitor implements an adaptive method that optimally estimates scaling and offset calibration parameters by using a computationally efficient, iterative online method to minimize the mean square error between a high bandwidth arterial pressure cardiac output (APCO) measurement generated by a first physiological sensor affixed to a patient and a relatively low bandwidth continuous cardiac output (CCO) measurement generated by a second physiological sensor also affixed to the patient. When calibration parameters are used to adjust an APCO measurement, the combined APCO/CCO estimate provided by the hemodynamic monitor has accuracy comparable to a CCO measurement, but also tracks cardiac output dynamical variations that are outside of the CCO algorithm bandwidth.

Abstract: A method and system for extracting cardiac cycle parameters from a respiration signal is disclosed. The technique comprises an array of piezoelectric sensors planted on the chest. The chest membrane exhibits the characteristics of bulky attenuator with certain time delay. Contractions and expansions of the heart and lungs muscles model a mechanical load and produce a relative induced strain on the piezoelectric sheet which in turn causes the piezoelectric material to generate a corresponding conformal voltage signal that is mapped with the heart actions. The resultant voltage signal is therefore used to extract and model the corresponding heart parameters utilizing piezoelectric as well as signal processing theories. a direct relationship is established between the output voltage produced by the piezoelectric transducer under hold breathing and the respiration signal collected by the same transducer with respiration.

Abstract: Intravascular devices, systems, and methods are disclosed. In some embodiments, side-loading electrical connectors for use with intravascular devices are provided. The side-loading electrical connector has at least one electrical contact configured to interface with an electrical connector of the intravascular device. A first connection piece of the side-loading electrical connector is movable relative to a second connection piece between an open position and a closed position, wherein in the open position an elongated opening is formed between the first and second connection pieces to facilitate insertion of the electrical connector between the first and second connection pieces in a direction transverse to a longitudinal axis of the intravascular device and wherein in the closed position the at least one electrical contact is electrically coupled to the at least one electrical connector received between the first and second connection pieces.

Abstract: Intravascular devices, systems, and methods are disclosed. In some embodiments, side-loading electrical connectors for use with intravascular devices are provided. The side-loading electrical connector has at least one electrical contact configured to interface with an electrical connector of the intravascular device. A first connection piece of the side-loading electrical connector is movable relative to a second connection piece between an open position and a closed position, wherein in the open position an elongated opening is formed between the first and second connection pieces to facilitate insertion of the electrical connector between the first and second connection pieces in a direction transverse to a longitudinal axis of the intravascular device and wherein in the closed position the at least one electrical contact is electrically coupled to the at least one electrical connector received between the first and second connection pieces.

Abstract: An apparatus and method for determining blood pressure has a control unit and a device for providing pulse wave data representative of a heart beat of a human subject. The subject has a body height, an age, and a gender. The control unit is configured for receiving the pulse wave data, selecting a portion of the pulse wave data indicative of one or more heart periods, and, for each respective heart period of the one or more heart periods, determining a systolic component of the respective heart period, approximating the systolic component with a first Gaussian function and a second Gaussian function, and determining a time difference between the first and second Gaussian functions. The blood pressure value of the subject is determined based on the time difference, the body height, and the age.

Abstract: Techniques for determining pulse transit time (PTT) and blood pressure measurements based on stethoscope data are provided. In one example, a system comprises a stethoscope component that monitors a heart and generates stethoscope data representative of a sound wave generated by the heart. The system can further comprise an analysis component that receives the stethoscope data and receives, from a photoplethysmography (PPG) component that monitors an extremity, PPG data representative of a pulse wave at the extremity. The analysis component can determine, based on the stethoscope data, a first time corresponding to closure of a tricuspid valve of the heart and can determine a PTT as a function of the first time and a second time corresponding to the pulse wave at the extremity that is determined based on the PPG data. Blood pressure measurements can be obtained from algorithms with the inputs of PTT or times determined based on the PPG data.

Abstract: Techniques for determining pulse transit time (PTT) and blood pressure measurements based on stethoscope data are provided. In one example, a system comprises a stethoscope component that monitors a heart and generates stethoscope data representative of a sound wave generated by the heart. The system can further comprise an analysis component that receives the stethoscope data and receives, from a photoplethysmography (PPG) component that monitors an extremity, PPG data representative of a pulse wave at the extremity. The analysis component can determine, based on the stethoscope data, a first time corresponding to closure of a tricuspid valve of the heart and can determine a PTT as a function of the first time and a second time corresponding to the pulse wave at the extremity that is determined based on the PPG data. Blood pressure measurements can be obtained from algorithms with the inputs of PTT or times determined based on the PPG data.

Abstract: A heart beat detection device comprises at least one optical reflection sensor to be positioned on the skin of a person. The sensor unit is provided with a light emitter and a corresponding light receiver which converts the light reflected by the skin into an electric signal and comprises electrically adjustable optical filters connected to the emitter, to the receiver or to both of them in order to select, upon operation, a desired light wavelength and perform processing of the signals thus obtained in order to reinforce the heart beat signal. A system with this device and a detection method are also described.

Abstract: A biological information measurement apparatus includes a biological sensor and an insertion portion, and the biological sensor is disposed at a position opposite the concha when the insertion portion is inserted in the external ear canal.

Abstract: An interface structure for a biological environment including at least one composite electrical impulse generating layer comprising a matrix phase of a piezo polymer material, a first dispersed phase of piezo nanocrystals, and second dispersed phase of carbon nanotubes, the first and second dispersed phase presented through the matrix phase. The piezo polymer material and piezo nanocrystal convert mechanical motion into electrical impulses and accept electrons to charge the composite impulse generating layer. The carbon nanotubes provide pathways for distribution of the electrical impulses to a surface of the composite impulse generating layer contacting the biological environment. The carbon nanotubes further provide for the delivery of the byproducts of the free radical degradation from the biological environment to both piezo-nanocrystals and piezo-polymer.

Abstract: An electroencephalogram analysis apparatus includes an electroencephalogram acquisition part and a comparison part. The electroencephalogram acquisition part is configured to acquire a first electroencephalogram measured at a first region on a head of a test subject and a second electroencephalogram measured at a second region positioned behind the first region on the head of the test subject. The comparison part is configured to compare a power of the first electroencephalogram in a specific frequency band with a power of the second encephalogram in the specific frequency band.

Abstract: Disclosed are devices, a systems, and methods for determining the dipole densities on heart walls. In particular, a triangularization of the heart wall is performed in which the dipole density of each of multiple regions correlate to the potential measured at various locations within the associated chamber of the heart.

Abstract: A device and system for providing mapping and treatment capabilities without increasing stiffness of the device. An embodiment of a device may include a flexible elongate body and at least one mapping element on the distal portion of the elongate body. Each mapping element may be an area of thermally conductive material, such as metallic nanoparticles, that is embedded within, integrated with, or deposited on the elongate body. The flexibility of the areas of thermally conductive material is at least substantially the same as that of the elongate body so the device may include many electrodes without compromising flexibility and maneuverability of the device. Alternatively, the device may include a treatment element coupled to the elongate body, such as a balloon. The mapping elements may be embedded within, integrated with, or deposited on the balloon and may have at least substantially the same flexibility as that of the balloon.

Abstract: Neural signal recording apparatus and method is described, in which a micro electrode array is utilized for performing a weighted matrix as a moving window providing superpositioning of electrode signals. A voltage distribution across the electrode array is determined as a Laplacian. The apparatus and method can be utilized in a variety of electrode sensing applications involving registering neural activity, and for electrode stimulation applications, or combinations thereof.

Abstract: The invention provides methods and apparatus for assessing the fit of an object such as a breast to a sensing surface, in a system for investigating the internal structure of an object. The assessment of fit can be carried out in real-time, with the object in situ, enabling the object to be repositioned as necessary before processing is carried out to investigate the internal structure of the object.

Abstract: A system for administering prescription medications including a composition and a receiver. The composition may include an active agent, an identifier, and a pharmaceutically acceptable carrier. The active agent may include a controlled pharmaceutical. The identifier may include: a partial power source having a first material and a second material configured to generate a voltage in contact with a conductive fluid within a body of a patient, and a signal generation component configured to use at least a portion of the generated voltage to transmit a signal through the body of the patient. The receiver may be positioned near the body of the patient, wherein the receiver is configured to: receive the signal transmitted through the body of the patient, and automatically report the signal for at least one of identification of the controlled pharmaceutical or tracking physical administration of the controlled pharmaceutical to the body of the patient.

Abstract: This disclosure relates to a flexible circuit for insertion into a pill capsule. The flexible circuit has a first portion having an electrical contact to electrically connect with a battery, a second portion having an electrical contact to electrically connect with the battery, a first arm separating the first portion and second portion, a third portion comprising a first antenna, a second arm separating the first portion and third portion, a fourth portion comprising a second antenna, a third arm separating the first portion and fourth portion, a third arm separating the first portion and fourth portion, and a fifth portion comprising a third antenna. The first portion, second portion, and first arm form a first receptacle to receive a battery. The third portion, fourth portion, and fifth portion form a second receptacle to receive a cube ferrite core.

Abstract: An apparatus for collecting volatile organic compounds from a gas sample such as alveolar breath or room air comprises an exhaust portion having at least a flow measuring device, and a discriminating device for distinguishing between alveolar and non-alveolar breath. The apparatus further comprises a collection portion distinct from and parallel with the exhaust portion having at least a collection component for receiving and concentrating gas samples within a collection chamber and a sampling component having a plurality of sampling devices for receiving the concentrated gas sample from the collection chamber and isolating VOCs contained in the gas sample. The collection chamber is compressible via a drive mechanism for precisely actuating the chamber to draw a gas sample into the collection chamber and circulating the sample to the sampling devices. Use of a drive mechanism enables the exhaust portion to be distinct from the collection portion, thereby mitigating cross-contamination therebetween.

Abstract: A user-wearable sensor device may be configured to be directly or indirectly secured to a user or to an article worn by the user. The user-wearable sensor device may include at least one sensor configured to collect sensor data associated with an orientation of the user, a display unit including at least one LED or other visual indicator, a battery configured to provide power to at least the display unit, and a control system. The control system may be configured to determine the orientation of the user based on sensor data collected by the at least one sensor, maintain the display unit in a deactivated state in the absence of a defined activation input, detect a defined activation input, activate the deactivated display unit in response to detecting the defined activation input, and control the activated display unit based on the determined orientation of the user.

Abstract: The present invention involves a test subject performing a sit-to-stand (STS) operation while wearing a device (MD) that contains an acceleration sensor (11) on the front of the chest. The present invention derives a muscular strength index (maximum acceleration value per unit of muscle mass during STS activity) representing the muscular strength of a human body by obtaining maximum acceleration value data from a signal expressing the size of an acceleration vector comprising a tri-axial component in detected acceleration, and using the maximum acceleration value data and the muscle mass or body fat mass of the text subject.

Abstract: The Cochleopalpebral reflex test is an electroacoustic transducer that emits a harmless sound stimulus that induces the cochlea palpebral reflex and the subsequent variation in the heart rate of the fetus that is detected as described in the prior paragraph. The Cochleopalpebral reflex test consists of a housing, a transducer, an amplifier, and a signal source. The transducer and amplifier are contained within the housing. The signal source is an externally generated electrical signal of a previously determined frequency. The previously determined frequency is in the audible range of humans. The electrical signal of a previously determined frequency is amplified by the amplifier and is converted into acoustic energy and introduced to the fetus through the transducer.

Abstract: Systems, methods and apparatuses described herein generally provide a millimetre size package-free complementary metal-oxide-semiconductor (“CMOS”) chip (referred to as a “die”) for the in situ (on-site) measurement or imaging of electrochemically detectable analytes.

Abstract: A catheter for intravascular use has a blood inlet and a blood outlet, and includes a membrane arranged in the catheter in such a way that at least one part of the blood flowing into the catheter via the blood inlet during operation comes into contact with the membrane. The membrane allows an exchange of at least one substance between a carrier medium and the blood. The carrier medium is a carrier fluid in which the substance to be exchanged can be dissolved, and the catheter includes a delivery device that is designed to at least partially compensate for a pressure difference between the blood inlet and the blood outlet during operation. A method for removing at least one substance from venous blood for diagnostic purposes uses a device of this type.

Abstract: Sleeves and cases for protecting medical devices against contamination, and methods for cleaning and disinfecting medical devices are provided. The various embodiments enable a single medical device to be used by more than one patient successively while reducing the risk of disease transmission from patient to patient.

Abstract: A method of monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a medium with time-varying optical properties is provided that includes providing a measurement data set that includes a plurality of measurement entries that include at least two measurements obtained from a patient before and after administration of the fluorescent agent. The measurements may include one or more of: a DRex signal detected by an unfiltered light detector during illumination by excitatory-wavelength light from first region adjacent to the diffuse reflecting medium; a Flr signal detected by a filtered light detector during illumination by excitatory-wavelength light; and a DRem signal detected by the unfiltered light detector during illumination by emission-wavelength light.

Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.

Abstract: An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes: a housing, the housing comprising a first opening; a skin interface member disposed in the first opening, the skin interface member comprising an inner member having a second opening, and an outer member at least partially surrounding the inner member and attached to the first opening; and at least one skin-penetration member configured and arranged to project within the second opening. Arrangements having alternatively constructed skin interface members are also described.