Patents Issued in November 29, 2018
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Publication number: 20180340105Abstract: Various opacifying adhesive compositions are described. The adhesives exhibit relatively high levels of opacity in wet conditions while maintaining acceptable adhesive properties. Also described are label assemblies and labeled containers using such adhesives. Related methods of use and preparation are also described.Type: ApplicationFiled: August 1, 2018Publication date: November 29, 2018Inventors: Peter J. HEEDERIK, Santosh HIRE, Darren B. MILLIGAN
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Publication number: 20180340106Abstract: The invention provides a B-stageable adhesive composition, based on the total weight of the adhesive composition, comprising: 13-59 wt % of an epoxy resin; 18-69 wt % of a carboxyl terminated butadiene-acrylonitrile copolymer; and 3-34 wt % of a polyterpene modified phenol-formaldehyde resin. Additionally, the B-stageable adhesive composition may further comprise a hardener, an inorganic filler including a flame retardant agent, a thermal conductive filler or the like. According to the disclosure of the application, a new B-stageable adhesive composition having a high tackiness, a high temperature resistance, a high flame resistance and a high thermal conductivity can be provided.Type: ApplicationFiled: December 1, 2015Publication date: November 29, 2018Inventors: Ping Zhou, Lianzhou Chen, Liang Qin, Lin Yang, Qunying Yang
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Publication number: 20180340107Abstract: The present invention relates to a hair treatment process for improved and milder oxidative treatment of hair, especially human hair. It was found out that when commonly used oxidative treatment compositions are mixed with another composition comprising predominantly carboxylic acids, the dyeing and/or bleaching effects of the compositions are improved, homogeneous dyeing/bleaching of hair fibers is achieved and natural cosmetic properties of hair is maintained.Type: ApplicationFiled: March 15, 2016Publication date: November 29, 2018Applicant: KAO GERMANY GMBHInventors: Bernd NÖCKER, Steven BREAKSPEAR, Peter BAUER, Jonathan WOOD
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Publication number: 20180340108Abstract: A nanofluid composed of a base fluid and a solid nanocomposite particle, where the solid nanocomposite particle consists of a carbon nanotube and a metal oxide nanoparticle selected from the group consisting of Fe2O3, Al2O3, and CuO. The metal oxide nanoparticle is affixed inside of or to the outer surface of the carbon nanotube, and the solid nanocomposite particle is homogeneously dispersed in the base fluid. The heat transfer and specific heat capacity properties of the nanofluid are measured using differential scanning calorimetry and heat exchanger experiments with different nanocomposite concentrations and different metal oxide percent loadings.Type: ApplicationFiled: July 13, 2018Publication date: November 29, 2018Applicant: King Fahd University of Petroleum and MineralsInventors: Muataz Ali Atieh, Abdallah Darweesh Manasrah, Usamah Ahmad Al-Mubaiyedh, Tahar Laoui, Rached Ben-Mansour
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Publication number: 20180340109Abstract: A rapidly dehydrating lost circulation material (LCM) composition is provided. The LCM composition may include a carrier fluid, volcanic ash, a viscosifier, and date tree rachis fibers. The carrier fluid may be water and the viscosifier may be a cellulosic microfiber. The LCM composition may form a rapidly dehydrating loss control slurry (RDLCS). The LCM composition may be formed by mixing the carrier fluid, the volcanic ash, the viscosifier, and the date tree rachis fibers in a mixer to form a homogenous mixture. Methods of lost circulation control and manufacture of a rapidly dehydrating LCM are also provided.Type: ApplicationFiled: August 7, 2018Publication date: November 29, 2018Inventor: Md Amanullah
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Publication number: 20180340110Abstract: A date tree fiber mix lost circulation material (LCM) is provided. The date tree fiber mix LCM may include includes date tree trunk fibers produced from date tree trunks and date tree leaf and leaf stem fibers produced from date tree leaves and leaf stems. The LCM include a mix of 30% by weight date tree trunk fibers and 70% date tree leaf and leaf stem fibers, 40% by weight date tree trunk fibers and 60% date tree leaf and leaf stem fibers, 50% by weight date tree trunk fibers and 50% date tree leaf and leaf stem fibers.Type: ApplicationFiled: August 7, 2018Publication date: November 29, 2018Inventor: Md Amanullah
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Publication number: 20180340111Abstract: Among the methods provided is a method comprising: providing an oil-based fluid formed by combining components that comprise a glycol ether additive comprising a glycol ether, wherein the glycol ether additive substantially increases the low-shear viscosity of the oil-based fluid at temperatures between approximately 120 degrees Fahrenheit (48.9 degrees Celsius) and 500 degrees Fahrenheit (260 degrees Celsius); and using the oil-based fluid to drill at least a portion of a well bore penetrating at least a portion of a subterranean formation.Type: ApplicationFiled: August 7, 2018Publication date: November 29, 2018Inventors: PHILIP WAYNE LIVANEC, JAY PAUL DEVILLE, CHESNEE LAE DAVIS, JONATHAN PAUL WALKER
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Publication number: 20180340112Abstract: A method of limiting or reducing permeability of a matrix to liquid and/or gas inflow is described. The method includes limiting inflow of water, liquid and/or gas into passages such as cavities, fissures, voids and the like, encountered in formations such as geological formations though can be used to form barriers to water, liquid or gas flow through a matrix. The method includes steps of measuring one or more parameters relating to the matrix and selecting one or more components of a multi-component sealing composition with reference to the measured parameters. The selected components are introduced into the matrix where it is set or coagulated in a non-exothermic or low exothermic process to form a seal barrier.Type: ApplicationFiled: May 23, 2018Publication date: November 29, 2018Inventors: Deon van Dyk, Nico Johan Grobler
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Publication number: 20180340113Abstract: Dissolving iron sulfide on the carbon steel tubing to yield chelated iron is achieved by treating the carbon steel tubing with a composition including an iron chelant and an additive. The additive includes at least one of an oxidizing agent and a base. A weight ratio of the iron chelant to the additive is in a weight range of 50:1 to 5:1.Type: ApplicationFiled: May 25, 2018Publication date: November 29, 2018Applicant: Saudi Arabian Oil CompanyInventors: Tao CHEN, Qiwei WANG, Fakuen Frank CHANG
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Publication number: 20180340114Abstract: Systems, methods and apparatus for injecting a diluted solid chemical, a diluted highly viscous fluid, or a diluted fluidified solid for inhibiting, decreasing or preventing precipitation and/or deposition of foulants and/or contaminants in oilfield tubulars. The use of solid chemicals or highly viscous fluids providing ease of shipment, greater economy in storage, shipment and delivery and increased ease of use.Type: ApplicationFiled: May 23, 2018Publication date: November 29, 2018Inventors: David Marc Daniel Fouchard, Saugata Gon
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Publication number: 20180340115Abstract: Systems, methods and apparatus for injecting a solid chemical for inhibiting, decreasing or preventing precipitation and/or deposition of foulants and/or contaminants in oilfield tubulars. The use of solid chemicals or highly viscous fluids providing ease of shipment, greater economy in storage, shipment and delivery and increased ease of use.Type: ApplicationFiled: May 23, 2018Publication date: November 29, 2018Inventors: David Marc Daniel Fouchard, Denise Lynn Gibson, Saugata Gon
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Publication number: 20180340116Abstract: The present invention discloses a phase change fracturing fluid system for phase change fracturing, including the following components in percentage by weight: 10%-40% of supramolecular construction unit, 0-40% of supramolecular function unit, 0.5%-2% of surfactant, 0-5% of inorganic salt, 0.5%-2% of oxidizing agent, 0-2% of cosolvent and the remaining of solvent. The supramolecular construction unit is melamine, triallyl isocyanurate, or a mixture thereof. The supramolecular function unit is vinyl acetate, acrylonitrile, or a mixture thereof. The solvent is methylbenzene, ethylbenzene, o-xylene, m-xylene or p-xylene. In the fracturing construction process, a conventional fracturing fluid is used for fracturing a formation first; the phase change fracturing fluid is then injected into the formation, or the phase change fracturing fluid and other fluids which cannot be subjected to phase change are injected into the formation together.Type: ApplicationFiled: September 20, 2016Publication date: November 29, 2018Applicant: SOUTHWEST PETROLEUM UNIVERSITYInventors: Liqiang ZHAO, Yong YANG, Guangyan DU, Donghe YU, Juan DU, Hang CHE, Zhifeng LUO, Guohua LIU, Yuxin PEI, Nianyin LI, Pingli LIU, Kun XU
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Publication number: 20180340117Abstract: Compositions and methods for coated or uncoated particulates, such as proppants, are provided that can, among other things, provide a hydrophobic surface that can enhance well productivity and other compositions and methods are disclosed.Type: ApplicationFiled: December 11, 2017Publication date: November 29, 2018Inventors: Kerry Drake, Spyridon Monastiriotis, Amr M. Radwan, Anthony P. Haddock, Robert Ray McDaniel, Andrew F. Nordquist
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Publication number: 20180340118Abstract: A composite having a solid particulate and a surface modifying treatment agent on the solid particulate wherein the surface modifying treatment agent has a hydrophobic tail and an anchor for adhering the hydrophobic tail onto the solid particulate. The anchor is an organophosphorus acid derivative. The composite may be used as a proppant in a hydraulic fracturing operation as well as a sand control particulate in a gravel packing operation. The presence of the surface modifying treatment agent on the surface of the solid particulate reduces the generation of fines and dust as well as the migration of sand during a hydraulic fracturing operation or a sand control operation. The presence of the surface modifying treatment agent on the surface of the solid particulate further enhances the crush resistance of the solid particulate.Type: ApplicationFiled: July 23, 2018Publication date: November 29, 2018Inventors: Terry D. Monroe, Brian B. Beall, Naima Bestaoui-Spurr, Sumit Bhaduri, Kimberly Lant, Hoang Le, Qi Qu
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Publication number: 20180340119Abstract: A wavelength conversion element comprising a crosslinked matrix and at least one phosphor dispersed in said matrix, wherein said matrix is made from a precursor material comprising a precursor having a structure chosen from one of the generic formulae is provided. Further, a light emitting device comprising a wavelength conversion element and a method for producing a wavelength conversion element are provided.Type: ApplicationFiled: May 23, 2017Publication date: November 29, 2018Inventors: Alan Piquette, Adam Scotch, Gertrud Kraeuter, Matthias Loster
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Publication number: 20180340120Abstract: The invention is directed to stabilizing functionalized polymers and compositions containing polysaccharides and polysaccharide derivatives functionalized with amine, alkyl and/or alkyl/amine moieties, and methods for reducing swelling of soils and especially clay-containing soils with stabilization functionalized polymers and compositions of the invention.Type: ApplicationFiled: August 3, 2018Publication date: November 29, 2018Applicant: HPPE LLCInventors: Ashoka V.R. Madduri, Matthew B. Blackmon, Sameer S. Vhora, Charles E. Milliron, Curtis J. Rodencal, Sanket Gandhi
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Publication number: 20180340121Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds having positive dielectric anisotropy, characterised in that it comprises one or more compounds of the formula I in a total concentration of ?40%, in which the parameters have the meanings indicated in claim 1, and to the use of the liquid-crystalline medium for electro-optical purposes, in particular in liquid-crystal light valves for lighting devices for motor vehicles, and to liquid-crystal light valves which comprise this medium and lighting devices for motor vehicles which contain such liquid-crystal light valves.Type: ApplicationFiled: October 5, 2016Publication date: November 29, 2018Applicant: MERCK PATENT GMBHInventors: Michael WITTEK, Dagmar KLASS
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Publication number: 20180340122Abstract: A system and method for repairing a coke oven having an oven chamber formed from ceramic bricks. A representative system includes a insulated enclosure insertable into the oven chamber and includes removable insulated panels that define an interior area for workers to work in. The insulated enclosure is movable between an expanded configuration and a compact configuration and moving the enclosure to the expanded configuration will decrease the distance between the insulated enclosure and the walls of the oven chamber. Removing the panels exposes the ceramic bricks and allows workers within the interior area to access and the bricks and repair the oven chamber while the oven chamber is still hot. A loading apparatus lifts and inserts the insulated enclosure into the oven chamber. The insulated enclosure can be coupled to additional insulated enclosures to form an elongated interior area.Type: ApplicationFiled: May 23, 2018Publication date: November 29, 2018Inventors: Jason Crum, Mark Anthony Ball, Gary Dean West, John Francis Quanci, Chun Wai Choi
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Publication number: 20180340123Abstract: A system and method of converting tires or other solid carbon based material is disclosed, wherein the system and method includes providing a chamber, feeding tires or other solid carbon based material or both into the chamber, indirectly heating the chamber, rotating the heated chamber with the material in the heated chamber, collecting solid residue from the reduced material from the chamber, collecting vapor from the reduced material from the chamber, and collecting residual solids from the reduced material from the chamber for re-use. The chamber has an interior surface and may include one or more ribs on the interior surface for rotating and tumbling the material in the chamber while heating the material.Type: ApplicationFiled: July 16, 2018Publication date: November 29, 2018Inventor: Fredrick Taylor
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Publication number: 20180340124Abstract: A method (100) is proposed for processing a mixture of substances which contains predominantly or solely hydrocarbons having from M to N carbon atoms, which include sulfur-containing hydrocarbons, a first feed being formed using fluid of the mixture of substances and being subjected to a first separation in which a first fraction is formed which contains predominantly or solely hydrocarbons having from X to Y carbon atoms and at least a portion of the sulfur-containing hydrocarbons contained in the first feed, and a second feed being formed using fluid of the first fraction and being subjected to a desulfurisation, in which the sulfur-containing hydrocarbons contained in the second feed are converted predominantly or completely and hydrocarbons having more than Y carbon atoms are formed as secondary products, with the result that a product mixture of the desulfurisation contains predominantly or solely hydrocarbons having from X to Y carbon atoms and the secondary products, where M is five or six, X is five oType: ApplicationFiled: September 15, 2016Publication date: November 29, 2018Inventors: Helmut Fritz, Ulrike Stiglmayr
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Publication number: 20180340125Abstract: A process is presented for recovering the components for a gasoline blending pool to meet the E70 specifications. The process includes the separation of the naphtha feedstock into a light naphtha stream and a heavy naphtha stream. The process further includes separating the light naphtha stream to recovery high quality non-normal hydrocarbons having normal boiling points above 70° C., and to separate for adding to the feed to the reforming unit, hydrocarbons that have lower boiling points.Type: ApplicationFiled: August 1, 2018Publication date: November 29, 2018Inventors: Gregory A. Funk, Jeffrey M. Bray
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Publication number: 20180340126Abstract: A process for reducing the environmental contaminants in a ISO8217 compliant Feedstock Heavy Marine Fuel Oil, the process involving: mixing a quantity of the Feedstock Heavy Marine Fuel Oil with a quantity of Activating Gas mixture to give a feedstock mixture; contacting the feedstock mixture with one or more catalysts to form a Process Mixture from the feedstock mixture; separating the Product Heavy Marine Fuel Oil liquid components of the Process Mixture from the gaseous components and by-product hydrocarbon components of the Process Mixture and, discharging the Product Heavy Marine Fuel Oil. The Product Heavy Marine Fuel Oil is compliant with ISO 8217A for residual marine fuel oils and has a sulfur level has a maximum sulfur content (ISO 14596 or ISO 8754) between the range of 0.05% wt. to 0.50% wt. The Product Heavy Marine Fuel Oil can be used as or as a blending stock for an ISO 8217 compliant, IMO MARPOL Annex VI (revised) compliant low sulfur or ultralow sulfur heavy marine fuel oil.Type: ApplicationFiled: July 30, 2018Publication date: November 29, 2018Applicant: Magema Technology, LLCInventors: Bertrand R. Klussman, Michael J. Moore
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Publication number: 20180340127Abstract: Provided is a process for limiting or preventing the formation and/or agglomeration of gas hydrates, comprising combining (1) a production fluid comprising an aqueous phase and one or more gasses and (2) at least one compound represented by formula (I) or a salt thereof as defined herein.Type: ApplicationFiled: November 25, 2016Publication date: November 29, 2018Applicant: Arkema FranceInventors: Tong Eak Pou, Frédéric Moser, Gilles Barrelo, Jean-Philippe Gillet
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Publication number: 20180340128Abstract: There is provided a press-fit lubricant composition comprising an unsaturated compound with an iodine value of 100 or more.Type: ApplicationFiled: April 27, 2018Publication date: November 29, 2018Applicants: KYODO YUSHI CO., LTD., DENSO CORPORATIONInventors: Takahiro NIHIRA, Hiroyuki ISHIKAWA, Masanori KOMABA, Shozo IKEJIMA, Yusuke ASADA, Takahiro NOZU, Takumi SHIOMI, Kyoji INUKAI
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Publication number: 20180340129Abstract: The present disclosure provides an ionic liquid produced from a renewable source and with excellent lubricating properties, and methods of making the same. The ionic liquid includes an anion salt of at least one of a fatty acid, a rosin acid, or derivative thereof. The method for making the ionic liquid or lubricant composition of the present disclosure includes admixing a cation and an anion in a ratio of about a 1.5:1 to about 1:1.5 at room temperature to form a reaction mixture, wherein the anion comprises at least one of a fatty acid, a rosin acid, derivative thereof, or a combination thereof, and the cation comprises at least one of choline, imidazolium, pyridium, pyrrolidinium, ammonium, phosphonium, sulfonium, derivatives thereof, or combinations thereof; maintaining the reaction mixture at a pH of about 6 to about 9; and drying under reduced pressure to yield a lubricant including an ionic liquid.Type: ApplicationFiled: May 24, 2018Publication date: November 29, 2018Inventor: Bing Wang
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Publication number: 20180340130Abstract: A lubricant composition comprises a perfluoropolyether oil and an adhesive component.Type: ApplicationFiled: April 27, 2018Publication date: November 29, 2018Inventors: Wataru Sawaguchi, Yusuke Asada, Takahiro Nozu, Takumi Shiomi, Kyoji Inukai
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Publication number: 20180340131Abstract: The invention relates to a lubricant coating for a medical container comprising a cross-linked lubricant composition comprising a mixture of non-reactive silicone with reactive silicone, characterized in that the reactive silicone comprises a mixture of vinyl-based silicone and acrylate-based silicone. The invention further relates to a lubricant composition usable as an intermediate product in the fabrication of a lubricant coating. The invention further relates to a medical container comprising a barrel and a stopper in gliding engagement within the barrel, comprising such a lubricant coating. The invention also relates to a process of manufacturing a medical container comprising a barrel and a stopper in gliding engagement within the barrel including depositing a lubricant composition on the inner surface of the barrel and/or on the stopper, and irradiating the coated barrel and/or stopper so as to cross-link the lubricant composition to form a lubricant coating.Type: ApplicationFiled: July 30, 2018Publication date: November 29, 2018Inventors: Virginie Santucci-Aribert, Emanuela Rossito
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Publication number: 20180340132Abstract: A system and method for degumming oil is used to increase oil yield and reduce impurities such as phosphorus. An oil feedstock, water and enzyme mixture is passed through a high shear mixing device prior to being fed to an agitated reactor equipped with a recirculation system. The recirculation system includes a second high shear mixing device that further mixes the oil mixture in the reactor during processing. The reacted mixture is discharged from the reactor to a downstream post-reaction system for separating the degummed oil from the reacted mixture. The separation step can be used to remove the phosphatides and other impurities from the reacted oil to form a purified oil product.Type: ApplicationFiled: March 6, 2018Publication date: November 29, 2018Inventors: Oleg Kozyuk, Peter Reimers
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Publication number: 20180340133Abstract: An oil extraction unit is provided. The extraction unit applies temperature and pressure to a sample to increase the yield of high quality essential oils while avoiding undesirable material phase changes. The extraction unit applies heat and pressure to upper and lower heat platens that are placed above and below the sample. The upper and lower heat platens include embedded heating elements that are used to draw the extracted oils from the material. In use, the extracted oils are drawn away from the higher temperature heating elements and towards an area outside of the heat platens. A cooling plate may be applied outside of the heat platens to further draw out the extracted oils away from the heat platens and limit exposure of the oils to elevated temperatures.Type: ApplicationFiled: May 23, 2018Publication date: November 29, 2018Inventor: David Carbone
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Publication number: 20180340134Abstract: A cable is disclosed that provides a scent by the outer layer having a fragrance impregnated material or that includes a housing that holds a scented cartridge.Type: ApplicationFiled: May 25, 2018Publication date: November 29, 2018Inventor: Josh Kovacevic
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Publication number: 20180340135Abstract: An optimal composition and method to dry-clean floors and surfaces eliminating the need to using water, allowing particle and dust removal in open and closed areas is presented. This invention is comprised of a solid wood waste or sawdust composition combined with lubricant agents and a method for correct usage for dry-cleaning in an easy, controlled and environmentally friendly manner by reducing harmful compounds in the cleaning process.Type: ApplicationFiled: August 2, 2018Publication date: November 29, 2018Inventor: José Germano GarcÃa Reyes
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Publication number: 20180340136Abstract: The present invention relates generally to surfactant and detergent compositions and, more specifically, to surfactant and detergent compositions containing an ethoxylated glycerine.Type: ApplicationFiled: August 7, 2018Publication date: November 29, 2018Inventors: Jeffrey John SCHEIBEL, Scott Leroy CRON, Praveen Kumar DEPA, Philip James GANZ, Daniele Lynn HIBBARD, Dennis Allen BECKHOLT, Rajan Keshav PANANDIKER, Patrick Christopher STENGER
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Publication number: 20180340137Abstract: The present invention relates generally to methods of making surfactant compositions and detergent compositions.Type: ApplicationFiled: August 7, 2018Publication date: November 29, 2018Inventors: Jeffrey John SCHEIBEL, Scott Leroy CRON, Praveen Kumar DEPA, Philip James GANZ, Daniele Lynn HIBBARD, Dennis Allen BECKHOLT, Rajan Keshav PANANDIKER, Patrick Christopher STENGER
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Publication number: 20180340138Abstract: The present disclosure relates to washing and cleaning agents comprising at least one protease and at least one organic compound of the formula (I) which acts as protease inhibitor, and is thus a suitable enzyme stabilizer, as well as the use of these compounds as enzyme stabilizers in washing and cleaning agents comprising protease. The corresponding washing and cleaning methods and the use of the agents describe here are also a component of the present disclosure.Type: ApplicationFiled: November 15, 2016Publication date: November 29, 2018Applicant: Henkel AG & Co. KGaAInventors: Andre Haetzelt, Timothy O'Connell
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Publication number: 20180340139Abstract: The present disclosure describes antimicrobial, sanitizing and other applications employing a synergistic combination of a quaternary ammonium compound and an anionic surfactant. The present disclosure is also related to non-antimicrobial applications employing a synergistic combination of a quaternary ammonium compound and an anionic and/or nonionic surfactant. The present disclosure is related to various forms of concentrated or use compositions containing the quaternary ammonium compound and an anionic surfactant (and in certain embodiments nonionic surfactants). In particular, the present disclosure provides compositions having desired foaming enhancement and methods employing the same for applications such as pot and pan compositions, hand soaps, facility sanitizing, and other soil removal applications with foam stabilization.Type: ApplicationFiled: July 16, 2018Publication date: November 29, 2018Inventors: Victor Fuk-Pong Man, Derrick Richard Anderson, Amanda Ruth Blattner
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Publication number: 20180340140Abstract: Provided is a culture bag accommodating a culture fluid, the culture bag is capable of suppressing foaming in the culture fluid when oscillating the culture fluid to perform a culture, and performing a culture with high efficiency. The culture bag includes a culture space accommodating a culture fluid, the culture space being an endless space to allow the culture fluid to circulate therein, in which the culture bag has an inner surface that comes into contact with the culture fluid to be accommodated therein, the inner surface including, at least in part thereof, a concave-convex region having a concave-convex structure.Type: ApplicationFiled: May 17, 2018Publication date: November 29, 2018Applicant: Dexerials CorporationInventors: Hirokazu ODAGIRI, Yasuyuki KUDO, Rishabh GUPTA, Keiji HONJO
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Publication number: 20180340141Abstract: Provided is a culture bag accommodating a culture fluid, the culture bag is capable of suppressing foaming in the culture fluid when oscillating the culture fluid to perform a culture, and performing a culture with high efficiency. The culture bag includes a culture space accommodating a culture fluid, the culture space being an endless space to allow the culture fluid to circulate therein, in which the culture bag has an inner surface that comes into contact with the culture fluid to be accommodated therein, the inner surface including, at least in part thereof, a first surface formed of a fine structure and a second surface formed of a structure different from that of the first structure.Type: ApplicationFiled: May 17, 2018Publication date: November 29, 2018Applicant: Dexerials CorporationInventors: Hirokazu ODAGIRI, Yasuyuki KUDO, Rishabh GUPTA, Keiji HONJO
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Publication number: 20180340142Abstract: A movable cell incubator contains: a body, a first lid, a second lid, and an electric control unit. The body includes a first internal space, a refrigeration room, and an airtight culture room. The first lid airtightly covers the culture room, the second lid airtightly covers the refrigeration room, and the control unit includes a microprocessor, a power module, a digital/analog conversion module defined between a microprocessor and the power module, a heating module controlling temperature of the culture room, a cooling module supplying cold source to the refrigeration room, a peristaltic pump module, a flow sensing module, a CO2 detective supply module supplying CO2 to the culture room, and a setting display module exposing and fixed on the first lid, with the peristaltic pump module aseptically connected between cell culture media and cell culture bag by multiple conveying tubes.Type: ApplicationFiled: May 25, 2017Publication date: November 29, 2018Inventor: LUN-KUANG LIU
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Publication number: 20180340143Abstract: The invention discloses an automatic off-line gas-water combined-washing membrane bioreactor, comprising a PLC automation control cabinet, a MBR reactor, a MBR membrane assembly, a rotating hood, an annular guide rail, a lifting device, a washing pipe network, an external interface, a gas washing pipe, a water washing pipe, a gas pump and a water pump, wherein the gas pump, the water pump and the three-way change valve are all connected with the PLC automation control cabinet, the washing pipe network is provided with several nozzles. The present invention adopts a full PLC automation control system, the PLC automation control cabinet controls a pressure washing pump (gas pump and water pump), and gas or water is injected into the washing pipe network by flexibly adjusting the three-way change valve, so that the operation is simple, the cleaning is complete, and the manual operation load is reduced.Type: ApplicationFiled: August 3, 2016Publication date: November 29, 2018Inventors: Xinyi CHEN, Shanglong WEN, Jianyun SHI, Yanfang ZHANG, Haochun ZHANG
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Publication number: 20180340144Abstract: Provided are methods for propagating mesenchymal stem cells (MSC), and particularly adipose derived stem cells, including incubating isolated cells obtained from a tissue or organ including MSC in a growth medium including an apoptosis inducing agent, under specified conditions. Further provided is an isolated cell population and kits for performing the methods.Type: ApplicationFiled: September 22, 2016Publication date: November 29, 2018Applicant: CELLECT BIOTHERAPEUTICS LTD.Inventors: Tal ALMOG, Shai YARKONI
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Publication number: 20180340145Abstract: Disclosed are means, methods, and compositions of matter useful for treatment of neuroinflammation, autoimmunity, transplant rejection, or graft versus host disease (GVHD) comprising exposing autologous immune cells to allogeneic amniotic fluid derived stem cells. In one embodiment peripheral blood mononuclear cells are cultured in the presence of amniotic fluid stem cells in the presence of interleukin-2 for a period of time sufficient to endow tolerogenic properties. Said tolerogenic properties include ability to suppress adaptive or innate immune responses. In another embodiment the invention provides methods of generating antigen specific immune regulatory cells by culture of lymphocytes together with amniotic fluid stem cells in the presence of antigen to which specific immune regulation is desired.Type: ApplicationFiled: May 23, 2018Publication date: November 29, 2018Applicant: Creative Medical Technologies, Inc.Inventors: Thomas Ichim, Amit Patel
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Publication number: 20180340146Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic ?-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.Type: ApplicationFiled: April 25, 2018Publication date: November 29, 2018Applicants: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.Inventor: Sarah FERBER
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Publication number: 20180340147Abstract: The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses and the use of those methods in the treatment of diseases or conditions such as viral, bacterial, pathogenic, or fungal infections or cancer. Such methods provide for boosting of antibody production through the use of IL-21 to overcome TFR cell suppression of antibody production.Type: ApplicationFiled: November 23, 2016Publication date: November 29, 2018Inventors: Peter T. Sage, Arlene H. Sharpe
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Publication number: 20180340148Abstract: Methods for using cyclin-dependent kinase (CDK) inhibitors to enhance growth and self-renewal of progenitor cells, in vitro and in vivo.Type: ApplicationFiled: May 24, 2018Publication date: November 29, 2018Inventors: Merav Socolovsky, Ralph Scully, Yung Hwang
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Publication number: 20180340149Abstract: A method for culturing osteocytes includes: obtaining an original three dimensional image of a bone tissue of a patient by collecting original image data of the bone tissue; determining a bone nidus and obtaining reverse data for fitting the bone nidus with normal bone parts other than the bone nidus by analyzing and dissecting the original three dimensional image; obtaining a preliminary three dimensional bone tissue image by simulating and matching the bone nidus and the normal bone parts other than the bone nidus based on the reverse data repeatedly; obtaining a complete three dimensional bone tissue image by designing an internal configuration of the preliminary three dimensional bone tissue image according to a bone tissue database; and obtaining a bone tissue culturing structure by printing the complete three dimensional bone tissue image through a multidimensional printer.Type: ApplicationFiled: July 19, 2016Publication date: November 29, 2018Inventors: Xiaowen ZHAO, Dongfeng ZHANG
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Publication number: 20180340150Abstract: Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described. Furthermore, the invention provides induced pluripotent stem cells and desired cell types essentially free of exogenous vector elements with the episomal expression vectors to express differentiation programming factors.Type: ApplicationFiled: December 15, 2017Publication date: November 29, 2018Applicant: Cellular Dynamics International, Inc.Inventor: Amanda MACK
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Publication number: 20180340151Abstract: A method is disclosed for making an artificial micro-gland having a continuous anisotropic membrane of two or more types of living cells. A first step includes forming a carrier fluid in a microchannel in a laminar flow of two distinct fluid flows. Another step includes introducing a template, which may itself be anisotropic, into the microchannel in a manner such that the template straddles the interface between the first fluid-flow and the second fluid-flow. In some embodiments two types of living cells within the template are separately attracted one of the fluid flows by the presence of an agent of taxis. In other embodiments, cells within one or the other of the fluid flows are attracted to agents within the template. Membranes form on the template and join together to form a complete cellular membrane around a reservoir.Type: ApplicationFiled: May 26, 2017Publication date: November 29, 2018Inventors: Manuel Marquez, Samantha M. Marquez
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Publication number: 20180340152Abstract: The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isolate, e.g., one that is safe in humans, for instance, one that does not result in significant disease, and genes from vaccine seed virus isolates which include a HA gene segment with a HA2 sequence encoding a HA2 that confers enhanced growth in cells in culture, such as Vero cells.Type: ApplicationFiled: July 26, 2018Publication date: November 29, 2018Inventors: Yoshihiro Kawaoka, Taisuke Horimoto, Shin Murakami
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Publication number: 20180340153Abstract: The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.Type: ApplicationFiled: November 23, 2016Publication date: November 29, 2018Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
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Publication number: 20180340154Abstract: The present invention relates to modified avian eggs which can be used to produce increased levels of virus. The present invention also relates to methods of producing viruses in avian eggs of the invention, as well as the use of the viruses obtained to prepare vaccine compositions.Type: ApplicationFiled: November 23, 2016Publication date: November 29, 2018Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp