Patents Issued in November 29, 2018
  • Publication number: 20180340205
    Abstract: This invention pertains to the general field of microbiology, and more specifically to transfer, inoculation and/or streaking of micro-organisms, e.g. for the purpose of obtaining individual colonies. Provided is a method for streaking a microbial sample onto a solid carrier, comprising the steps of: a) contacting at least one ferromagnetic particle with a solid carrier, followed or preceded by providing the particle with at least part of said sample, and b) applying a magnetic field gradient to allow for magnetically controlled motion of said particle on said surface, such that at least part of the sample is streaked onto the solid carrier. Also provided is an apparatus for carrying out such method in an (semi-)automated fashion.
    Type: Application
    Filed: August 1, 2018
    Publication date: November 29, 2018
    Applicant: BD KIESTRA B.V.
    Inventors: Trienko Marten Van Der Kaap, Martijn Kleefstra, lngela Marie Sofie Edlund Tjernberg, Jetze Botma
  • Publication number: 20180340206
    Abstract: The present invention relates to the pharmaceutics, biotechnological and chemical, and particularly to a process for preparing a composition for detecting and measuring the concentration of endotoxins or lipopolysaccharides, peptidoglycans and (1,3)-?-D-glucans, using an extract from the hemocytes of the lobster as a starting material, the changes to the composition to increase the sensitivity, and processes for measuring endotoxins, peptidoglycans and (1,3)-?-D-glucans using said composition.
    Type: Application
    Filed: June 20, 2018
    Publication date: November 29, 2018
    Inventors: ROLANDO PERDOMO MORALES, Vivian Montero Alejo, Erick Perera Bravet, Jorge Ernesto Calero Carbonell, Zenia Pardo Ruiz, Marlene Porto Verdecia, Yamile Vega Hurtado
  • Publication number: 20180340207
    Abstract: The invention relates to a mutant polypeptide having creatine amidinohydrolase activity, where the polypeptide both retains thermostable activity in the presence of reagents that modify thiol groups. The invention further relates to methods for producing the mutant polypeptide; and to a sensor comprising the mutant polypeptide for use in the measurement of creatinine in samples of physiological fluids. Additionally, the invention teaches how to use the mutant polypeptide to enhance the life-time of a creatinine sensor, and a method for producing the sensor.
    Type: Application
    Filed: February 23, 2016
    Publication date: November 29, 2018
    Inventors: Palle SCHNEIDER, Jens ØSTERGAARD, Thomas Steen HANSEN
  • Publication number: 20180340208
    Abstract: Described herein is a method for producing and calibrating isotopically labeled peptides for use as standards for a variety of analytical and qualitative purposes. An expression construct, encoding a superprotein comprised of concatenated peptides, proteolysis sensitive sites, a detectable moiety, and optionally, a purification tag, is provided. The quantity of the superprotein and/or peptide is determined using the detectable moiety. The superprotein is subjected to proteolytic digestion and the peptides are isotopically labeled.
    Type: Application
    Filed: October 14, 2016
    Publication date: November 29, 2018
    Applicant: WOODS HOLE OCEANOGRAPHIC INSTITUTION
    Inventors: MAKOTO SAITO, MATTHEW R. MCILVIN
  • Publication number: 20180340209
    Abstract: Provided are methods for determining the amount of total thiamine in a body fluid sample using liquid chromatography and mass spectrometry. Total thiamine is converted to free thiamine by treatment with an acid phosphatase prior to thiamine separation and quantification.
    Type: Application
    Filed: July 16, 2018
    Publication date: November 29, 2018
    Inventors: Sum Chan, Qibo Jiang, Richard E. Reitz
  • Publication number: 20180340210
    Abstract: The present invention relates in general to cellular analysis tools and more particularly to methods for detecting or determining cyclic nucleotide concentrations in samples. Samples containing cyclic nucleotides may be contacted with a cyclic nucleotide-dependent protein kinase and a detection system which includes a substrate for the cyclic nucleotide-dependent protein kinase. The activities in cyclic nucleotide related pathways may be measured using the detection system.
    Type: Application
    Filed: June 7, 2018
    Publication date: November 29, 2018
    Inventors: Said A. Goueli, Kuei-Hsuan Hsiao, Meera Kumar, Jolanta Vidugiriene
  • Publication number: 20180340211
    Abstract: A glucose dehydrogenase having modified electron transfer properties, and a glucose measurement method and measuring kit using the glucose dehydrogenase are provided. Provided are a glucose dehydrogenase having at least 1, 2 or 3 amino acid substitutions, for example, amino acid substitution with a polar amino acid or alanine, in the region corresponding to the 457th to 477th position in SEQ ID NO: 1 of a glucose dehydrogenase having homology with SEQ ID NO: 1, a glucose measurement method, a measurement reagent kit and a sensor using the glucose dehydrogenase. The electron transfer properties of the glucose dehydrogenase of the present invention is modified and can be used in measuring glucose in the presence of a mediator with reduced concentration or in the absence of a mediator, and can be used, for example, in continuous glucose measurement.
    Type: Application
    Filed: October 31, 2016
    Publication date: November 29, 2018
    Inventors: Yosuke MASAKARI, Seiichi HARA
  • Publication number: 20180340212
    Abstract: The present disclosure encompasses methods and compositions for analyzing telomeres of genomic DNA, including the length of one or more telomeres. In specific embodiments, methods and compositions are employed for identification of the length of the shortest telomere in a collection of genomic DNA. In particular cases, the method greatly suppresses amplification of intra-genomic DNA fragments in comparison to telomeres by hindering their amplification using particular adaptors.
    Type: Application
    Filed: May 10, 2018
    Publication date: November 29, 2018
    Inventors: Jerry W. Shay, Tsung-Po Lai
  • Publication number: 20180340213
    Abstract: Disclosed are methods for quantitative multiplex PCR in which any combination of target sequences can be paired with each other. The reaction mix for use in these methods can be assembled all at one time and the method performed without additional manipulation between the first and last rounds of replication.
    Type: Application
    Filed: May 25, 2017
    Publication date: November 29, 2018
    Applicant: DIATHERIX Laboratories, Inc.
    Inventors: Danielle JOHNSON, Cheryl SESLER, Stefan BRZEZINSKI, Elena GRIGORENKO
  • Publication number: 20180340214
    Abstract: Methods are disclosed herein for quantitative multiplex PCR. The methods proceed through at least two successive rounds of amplification, for example, a target enrichment step and a target amplification step.
    Type: Application
    Filed: May 25, 2017
    Publication date: November 29, 2018
    Applicant: DIATHERIX Laboratories, Inc.
    Inventors: Stefan BRZEZINSKI, Danielle JOHNSON, Cheryl SESLER, Elena GRIGORENKO
  • Publication number: 20180340215
    Abstract: The present invention provides a combination of genomic and computational technologies to provide rapid, portable sample analysis for sequencing or identifying a target sequence involving generating probes for use in analyzing a sample which may comprise a target sequence.
    Type: Application
    Filed: August 26, 2016
    Publication date: November 29, 2018
    Inventors: Hayden Metsky, Andreas Gnirke, Christian Matranga, Daniel Park, Pardis Sabeti
  • Publication number: 20180340216
    Abstract: The invention pertains to construction of next-generation DNA sequencing (NGS) libraries for whole genome sequencing, targeted resequencing, sequencing-based screening assays, metagenomics, or any other application requiring sample preparation for NGS.
    Type: Application
    Filed: May 25, 2018
    Publication date: November 29, 2018
    Applicant: Integrated DNA Technologies, Inc.
    Inventors: Mirna Jarosz, Madelyn Light, Jiashi Wang, Kristina Giorda
  • Publication number: 20180340217
    Abstract: The present method of detection involves increasing an amount of analyte molecules by an isothermal molecular amplification approach. In the present approach a starting molecule of interest may be amplified through a reaction it induces with specifically engineered and functionalized particles, namely protected particles A and storage particles B. This reaction may result in a set of output DNA molecules that is larger in number than the input DNA molecules. Thus the reaction between nanoparticles for amplification of a certain DNA sequence (input DNA molecules) may occur when there is a match with a targeted molecule (stored molecules on storage particles B,) and if the DNA sequence of the input DNA molecules does not match (partially or completely) the targeted molecule the reaction may not occur. Without a certain molecular input of the input DNA molecule the reaction may not occur.
    Type: Application
    Filed: May 18, 2018
    Publication date: November 29, 2018
    Inventors: Oleg Gang, Suchetan Pal
  • Publication number: 20180340218
    Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.
    Type: Application
    Filed: March 9, 2018
    Publication date: November 29, 2018
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Omar ABUDAYYEH, James Joseph COLLINS, Jonathan GOOTENBERG, Feng ZHANG, Eric S. LANDER
  • Publication number: 20180340219
    Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.
    Type: Application
    Filed: March 9, 2018
    Publication date: November 29, 2018
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Omar ABUDAYYEH, James Joseph COLLINS, Jonathan GOOTENBERG, Feng ZHANG, Eric S. LANDER
  • Publication number: 20180340220
    Abstract: Electronic sensors configured to detect single molecule targets and methods of using and manufacturing such electronic sensors are disclosed. A sensor may include a first electrode and a second electrode separated by a sensor gap. The first and second electrodes can be coupled by a sensor complex that can include a biopolymer bridge molecule and a probe. The probe can interact with a target molecule, and interaction of the probe and target molecule can produce a signal suitable to provide detection of the target molecule.
    Type: Application
    Filed: June 18, 2018
    Publication date: November 29, 2018
    Inventors: Barry L. Merriman, Paul W. Mola
  • Publication number: 20180340221
    Abstract: The present disclosure provides reagents and methods for molecular proximity detection of specific endogenous nucleic acids in situ using RNA-guided nucleic acid binding proteins.
    Type: Application
    Filed: September 23, 2016
    Publication date: November 29, 2018
    Applicant: SIGMA-ALDRICH CO. LLC
    Inventors: Gregory D Davis, Vikas B Palhan, Carol A. Kreader
  • Publication number: 20180340222
    Abstract: The present application relates to a new class of macroporous bio/inorganic hybrids, engineered through a high-throughput materials screening approach that entrap micron-sized concatemeric DNA aptamers. The entrapment of these long-chain DNA aptamers allows their retention within the macropores of the silica material, so that aptamers can interact with high molecular weight targets such as proteins.
    Type: Application
    Filed: May 25, 2018
    Publication date: November 29, 2018
    Applicant: McMaster University
    Inventors: Carmen Carrasquilla, Yingfu Li, John D. Brennan
  • Publication number: 20180340223
    Abstract: Disclosed is a method for identifying a greater risk for developing bronchopulmonary dysplasia (BPD) of a preterm infant. The method comprises obtaining a genomic DNA sample from the preterm infant's mother, genotyping rs1800566 SNP in the NQO1 gene, and determining the preterm infant as being at risk of developing BPD if the genotype of the rs1800566 SNP is TT. Also disclosed are a primer pair for genotyping rs1800566 SNP in the NQO1 gene, and a method thereof.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 29, 2018
    Applicant: Meribank Biotech Co., Ltd.
    Inventors: Chang-Yo Hsuan, Willie Lin, Wei-Ting Liu, Meng-Hua Lee, Ting-Ting Tseng
  • Publication number: 20180340224
    Abstract: Disclosed is a method for identifying a greater risk for developing bronchopulmonary dysplasia (BPD) of a preterm infant. The method comprises obtaining a genomic DNA sample from the preterm infant's mother, genotyping rs2280789 SNP in the RANTES gene, and determining the preterm infant as being at risk of developing BPD if the genotype of the rs2280789 SNP is CC. Also disclosed are a primer pair for genotyping rs2280789 SNP in the RANTES gene, and a method thereof.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 29, 2018
    Applicant: Meribank Biotech Co., Ltd.
    Inventors: Chang-Yo HSUAN, Willie LIN, Wei-Ting LIU, Meng-Hua LEE, Ting-Ting TSENG
  • Publication number: 20180340225
    Abstract: An intestinal microorganism metagenomic feature is a bacteroid intestinal pattern. By using the intestinal metagenomic pattern, it was found that type 2 diabetic patients with different intestinal parasitic bacterial flora had remarkably different responses to treatment with the diabetic hypoglycemic drug acarbose. Therefore, before treatments, the intestinal patterns of the patients can be assessed to select those patients likely to experience optimal curative effects, and to determine whether acarbose is suitable for the treatment of individual patients with type 2 diabetes. In addition, while intestinal patterns are conventionally distinguished by DNA sequencing or PCT amplification of parasitic bacteria in excrements, the intestinal patterns can be well distinguished using a bile acid composition, especially secondary bile acids, under baseline conditions. The intestinal patterns can be identified through markers in blood, and then be used as markers for diagnosis.
    Type: Application
    Filed: December 16, 2015
    Publication date: November 29, 2018
    Applicants: SHANGHAI INSTITUTE FOR ENDOCRINE AND METABOLIC DISEASES, BGI Shenzhen
    Inventors: Guang NING, Dongya ZHANG, Weiqing WANG, Xiaokai WANG, Yanyun GU, Qiang FENG, Ruixin LIU, Xiaoqiang XU, Huahui REN, Huanzi ZHONG
  • Publication number: 20180340226
    Abstract: It was determined that plasma-derived exosomes from either obese (OB) or obstructive sleep apnea (OSA) children with evidence of endothelial dysfunction (ED). Such ED exosomes lead to up-regulation of adhesion molecules in endothelial cells. Exosomal miRNA cargo differences underlie the mechanisms accounting for the presence of ED. Specifically, expression of miRNA-630 is reduced in circulating exosomes of either obese or OSA children with ED, and normalizes in OSA children with ED after treatment along with restoration of endothelial function. These findings elucidate a novel role of exosomal miRNA-630 as a putative key mediator of vascular function and a biomarker of cardiovascular disease (CVD) risk in children.
    Type: Application
    Filed: August 22, 2016
    Publication date: November 29, 2018
    Applicant: Serenium, Inc.
    Inventors: David Gozal, Leila Gozal
  • Publication number: 20180340227
    Abstract: Materials and methods for identifying carriers of genetic determinants of spinal muscular atrophy are disclosed. In particular, polymorphisms in linkage disequilibrium are associated as markers of spinal muscular atrophy alleles detectable by various techniques, including multiplex ligation-dependent probe analysis, sequence analysis, and RFLP detection. The materials and methods of the disclosure are particularly useful in identifying silent (2+0) carriers of spinal muscular atrophy in which two copies of the SMN1 gene are located on a single human chromosome 5 and no copies of the gene are located on the chromosome 5 homolog.
    Type: Application
    Filed: May 21, 2018
    Publication date: November 29, 2018
    Inventors: Lisa Edelmann, Robert J. Desnick
  • Publication number: 20180340228
    Abstract: The invention relates to methods for diagnosing Parkinson's Disease PAD) with miRNA markers. Towards the identification of biomarkers for diagnosis of PD, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified.
    Type: Application
    Filed: June 11, 2018
    Publication date: November 29, 2018
    Inventors: ANDREAS KELLER, Cord Friedrich Stahler, Jan Kirsten, Eckart Meese, Christina Backes, Petra Leidinger
  • Publication number: 20180340229
    Abstract: The present disclosure provides diagnostic methods that are relevant to various cancers and which comprise improvements on a BH3 profiling diagnostic method.
    Type: Application
    Filed: January 12, 2016
    Publication date: November 29, 2018
    Inventors: Elisha J. DETTMAN, Michael H. CARDONE
  • Publication number: 20180340230
    Abstract: The present invention relates to highly sensitive and specific methods for detection of nucleic acids, which for example are useful for detection of rare mutations, or for detection of low-abundance variants in nucleic acids sequences. The methods involve an asymmetric incremental polymerase reaction (AIPR) followed by an exponential polymerase chain reaction (PCR).
    Type: Application
    Filed: May 18, 2016
    Publication date: November 29, 2018
    Inventors: Lao Hayamizu Saal, Anthony Miles George
  • Publication number: 20180340231
    Abstract: Described herein are innovations for classifying subtypes of DLBCL, as well as using the results of classification for diagnosis, prognosis, and therapy selection. In this way, the classifier can effectively classify subtypes of DLBCL and provide meaningful output for the benefit of medical practices and DLBCL patients. Also described are arrays and kits that can be used to measure expression of DLBCL signatures genes.
    Type: Application
    Filed: September 29, 2016
    Publication date: November 29, 2018
    Applicant: HTG Molecular Diagnostics, Inc.
    Inventors: Bonnie LaFleur, Qian Liu, John W. Luecke, Patrick C. Roche
  • Publication number: 20180340232
    Abstract: A novel family of human mitochondrial RNAs, referred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the chimeric RNAs are provided. The described oligonucleotides or their analogs can be used for cancer diagnostics and cancer therapy as well as for research. In one embodiment of this invention, these oligonucleotides hybridize with the sense or with the antisense mitochondrial chimeric RNAs, and the result of the hybridization is useful to differentiate between normal proliferating cells, pre-cancer cells and cancer cells. In another embodiment of the invention, the compositions comprise oligonucleotides that hybridize with the human chimeric RNAs resulting in cancer cell and pre-cancer cell death, while there is no effect in normal cells, constituting therefore, a novel approach for cancer therapy.
    Type: Application
    Filed: January 10, 2018
    Publication date: November 29, 2018
    Inventors: Luis O. BURZIO, Jaime E. VILLEGAS, Veronica A. BURZIO
  • Publication number: 20180340233
    Abstract: The invention provides methods and reagents for diagnosing prostate cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Application
    Filed: May 21, 2018
    Publication date: November 29, 2018
    Inventors: Ekkehard Schütz, Julia Beck, Howard Urnovitz
  • Publication number: 20180340234
    Abstract: A method for detecting large rearrangements in BRCA1 and BRCA2 genes includes amplifying a nucleic acid sample in the presence of a primer pool to produce amplicons, where the primer pool includes target specific primers targeting regions of exons of the BRCA1 and BRCA2 genes. The method further includes sequencing the amplicons to generate a plurality of reads, mapping the reads to a reference sequence, determining a number of reads per amplicon for the amplicons associated with the exons of the BRCA and the BRCA2 genes, determining exon copy numbers for the exons of the BRCA1 and BRCA2 genes based on the number of reads per amplicon, detecting an exon deletion or duplication based on the exon copy numbers, and detecting a whole gene deletion of the BRCA1 or BRCA2 gene based on the number of reads per amplicon associated with the exons of the BRCA1 and BRCA2 genes.
    Type: Application
    Filed: May 25, 2018
    Publication date: November 29, 2018
    Inventors: Charles Scafe, Dumitru Brinza, James Veitch, Rongsu Qi, Fiona Hyland
  • Publication number: 20180340235
    Abstract: Methods for detecting genomic rearrangements in BRCA1 and BRCA2 genes at high resolution using Molecular Combing and for determining a predisposition to a disease or disorder associated with these rearrangements including predisposition to ovarian cancer or breast cancer. Primers useful for producing probes for this method and kits for practicing the methods.
    Type: Application
    Filed: June 1, 2018
    Publication date: November 29, 2018
    Applicant: GENOMIC VISION
    Inventors: Aaron BENSIMON, Maurizio CEPPI, Kevin CHEESEMAN, Emmanuel CONSEILLER, Pierre WALRAFEN
  • Publication number: 20180340236
    Abstract: It is intended to provide a rapid, convenient, and highly accurate method for determining the prognosis of cancer. The present invention provides a method for determining the prognosis of a renal cell carcinoma patient, comprising: (1) treating genomic DNA prepared from a renal tissue of a subject with bisulfite; (2) amplifying the bisulfite-treated DNA by PCR; (3) subjecting the obtained PCR amplification product to ion exchange chromatography; (4) obtaining the retention time of a detection signal obtained by the chromatography; and (5) determining the renal cell carcinoma of the subject as having poor prognosis when the result of the step (4) is shorter than a retention time serving as a reference.
    Type: Application
    Filed: June 5, 2018
    Publication date: November 29, 2018
    Applicants: NATIONAL CANCER CENTER, SEKISUI MEDICAL CO., LTD.
    Inventors: Yae KANAI, Eri ARAI, Yuriko NEMOTO, Takuya YOTANI
  • Publication number: 20180340237
    Abstract: A burner assembly for top combustion hot blast stove including a burner surrounded by a burner shell, where the burner has a circular cross-section; a number of air nozzles arranged for tangentially feeding air to the burner, the air nozzles being connected to one or more air distribution chambers; a number of gas nozzles arranged for tangentially feeding gas to the burner, the gas nozzles being connected to one or more gas distribution chambers; wherein the air nozzles are arranged in one or more inclined or vertical stacked arrays of air nozzles, each inclined or vertical stacked array being in connection with one inclined or vertical air distribution chamber; the gas nozzles are arranged in one or more inclined or vertical stacked arrays of gas nozzles, each inclined or vertical stacked array being in connection with one inclined or vertical gas distribution chamber; and the inclined or vertical air distribution chamber(s) and the inclined or vertical gas distribution chamber(s) are arranged along the circ
    Type: Application
    Filed: November 28, 2016
    Publication date: November 29, 2018
    Inventors: Stefan THALER, Stefan KESSLER, Eric SCHAUB, Hossein SA'DODDIN, Jurij LUFT
  • Publication number: 20180340238
    Abstract: A high strength/highstrength, high toughness steel sheet having tensile strength, Charpy impact absorption energy, and ductile fracture rate are equal to or greater than specified value comprises, in mass %, 0.03-0.08% of C, 0.01-0.50% of Si, 1.5-2.5% of Mn, 0.001-0.010% of P, 0.0030% or less of S, 0.01-0.08% of Al, 0.010-0.080% of Nb, 0.005-0.025% of Ti, 0.001-0.006% of N, at least one substance selected from among 0.01-1.00% of Cu, 0.01-1.00% of Ni, 0.01-1.00% of Cr, 0.01-1.00% of Mo, 0.01-0.10% of V, and 0.0005-0.0030% of B, and a remainder of Fe and unavoidable impurities. At a position at ½ the sheet thickness, the area ratio of island-like martensite is less than 3%, the area ratio of bainite is 90% or more, and the average particle size of cementite within the bainite is 0.5 ?m or less.
    Type: Application
    Filed: March 25, 2016
    Publication date: November 29, 2018
    Applicant: JFE STEEL CORPORATION
    Inventors: Hideyuki Kimura, Shusaku Ota, Nobuyuki Ishikawa, Shinichi Kakihara, Ryo Nagao
  • Publication number: 20180340239
    Abstract: A high-silicon steel sheet is excellent in terms of punching workability and magnetic property. The high-silicon steel sheet has a chemical composition containing, by mass %, C: 0.02% or less, P: 0.02% or less, Si: 4.5% or more and 7.0% or less, Mn: 0.01% or more and 1.0% or less, Al: 1.0% or less, O: 0.01% or less, N: 0.01% or less, and the balance being Fe and inevitable impurities, a grain-boundary oxygen concentration (oxygen concentration with respect to chemical elements segregated at grain boundaries) of 30 at % or less, and a microstructure in which a degree of integration P(211) of a {211}-plane of ?-Fe on a surface of the steel sheet is 15% or more P(211)=p(211)/S×100(%), wherein S=p(110)/100+p(200)/14.93+p(211)/25.88+p(310)/7.68+p(222)/1.59+p(321)/6.27+p(411)/1.55, and p(hkl): integrated intensity of a peak of X-ray diffraction of an {hkl}-plane.
    Type: Application
    Filed: September 8, 2016
    Publication date: November 29, 2018
    Applicant: JFE Steel Corporation
    Inventors: Tomoyuki Okubo, Tatsuhiko Hiratani, Yoshihiko Oda, Hiroaki Nakajima
  • Publication number: 20180340240
    Abstract: A decoating system includes a dust cyclone and a dust briquetter. The dust cyclone is configured to receive an exhaust gas from a decoating kiln of the decoating system and remove organic particulate matter from the exhaust gas as dust. The dust briquetter is configured to receive the dust from the dust cyclone and compress the dust into dust briquettes.
    Type: Application
    Filed: May 25, 2018
    Publication date: November 29, 2018
    Applicant: Novelis Inc.
    Inventors: Don Doutre, Allan Sweeney
  • Publication number: 20180340241
    Abstract: A method of suppressing the Samson phase, Al3Mg2, at grain boundaries in Aluminum, comprising providing aluminum in a container, adding boron to the container, providing an inert atmosphere, arc-melting the aluminum and the boron, and mixing the aluminum and the boron in the container to form an alloy mixture. An aluminum magnesium alloy with reduced Samson phase at grain boundaries made from the method of providing aluminum in a container, adding boron to the container, providing an inert atmosphere, arc-melting the aluminum and the boron, and mixing the aluminum and the boron in the container to form an alloy mixture.
    Type: Application
    Filed: May 11, 2018
    Publication date: November 29, 2018
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Ramasis Goswami, Syed B. Qadri
  • Publication number: 20180340242
    Abstract: A high temperature, high strength Ni—Co—Cr alloy is provided. The alloy includes, in weight percent (wt. %): 23.5 to 25.5% Cr, 15.0 to 22.0% Co, 1.1 to 2.0% Al, 1.0 to 1.8% Ti, 0.95 to 2.2% Nb, less than 1.0% Mo, less than 1.0% Mn, up to 0.24% Si, less than 3.0% Fe, less than 0.3% Ta, less than 0.3% W, 0.005 to 0.08% C, 0.01 to 0.3% Zr, 0.0008 to 0.006% B, up to 0.05% rare earth metals, and a balance of Ni plus trace impurities.
    Type: Application
    Filed: August 1, 2018
    Publication date: November 29, 2018
    Applicant: Huntington Alloys Corporation
    Inventors: Brian A. BAKER, Gaylord D. Smith, Ronald D. Gollihue
  • Publication number: 20180340243
    Abstract: Provided is an aluminum alloy material with high strength and low thermal expansion coefficient even under high temperature environments. An aluminum alloy material according to the present invention has a composition consisting of: Si: 13 mass % to 15 mass %, Cu: 2.0 mass % to 6.0 mass %, Mg: 0.2 mass % to 1.5 mass %, Fe: 0.4 mass % to 0.8 mass %, Ni: 0.2 mass % to 0.8 mass %, P: 0.005 mass % to 0.015 mass %, and the balance being Al and inevitable impurities.
    Type: Application
    Filed: May 22, 2018
    Publication date: November 29, 2018
    Applicant: SHOWA DENKO K.K.
    Inventor: Takumi MARUYAMA
  • Publication number: 20180340244
    Abstract: The present disclosure generally provides 6xxx series aluminum alloys and methods of making the same, such as through casting and rolling. The disclosure also provides products made from such alloys. The disclosure also provides various end uses of such products, such as in automotive, transportation, electronics, aerospace, and industrial applications, among others.
    Type: Application
    Filed: May 25, 2018
    Publication date: November 29, 2018
    Applicant: Novelis Inc.
    Inventors: Sazol Kumar Das, Rajeev G. Kamat, Milan Felberbaum
  • Publication number: 20180340245
    Abstract: A multi-principal element, corrosion resistant alloy is disclosed. The alloy has the following composition in weight percent: Co about 13 to about 28 Ni about 13 to about 28 Fe+Mn about 13 to about 28 Cr about 13 to about 37 Mo about 8 to about 28 N about 0.10 to about 1.00. The alloy also includes the usual impurities found in corrosion resistant alloys intended for the same or similar use. In addition, one or both of W and V may be substituted for some or all of the Mo. The alloy provides a solid solution that is substantially all FCC phase, but may include minor amounts of secondary phases that do not adversely affect the corrosion resistance and mechanical properties provided by the alloy.
    Type: Application
    Filed: March 8, 2018
    Publication date: November 29, 2018
    Inventors: Samuel J. Kernion, Alberto Polar-Rosas
  • Publication number: 20180340246
    Abstract: A method for coiling a metal strip that is heat-treated in a furnace immediately before coiling and fed to a coiler at an outlet speed, and then coiled at the coiler at an elevated temperature. The future outlet speed of the metal strip and the heat losses from the metal strip between the furnace and the coiler are calculated via a predictive model and the furnace is controlled by the predictive model such that the metal strip is coiled at a pre-defined temperature within a maximum deviation of +/?5° C.
    Type: Application
    Filed: May 25, 2018
    Publication date: November 29, 2018
    Inventors: Thomas Hofbauer, Florian Leeber, Walter Kautz, Martin Fein
  • Publication number: 20180340247
    Abstract: A method for manufacturing a golf club head includes aging heat treat a sheet material made of a titanium alloy at 650-750° C. for 10-12 hours to obtain an aging heat treated sheet material. The aging heat treated sheet material is hot rolled to form a striking plate. The striking plate is annealed at 700-800° C. for 30-60 minutes to obtain an annealed striking plate. The annealed striking plate is welded to a club head body made of the titanium alloy to form a semi product. The semi product of the golf head is annealed at 500-700° C. for 30-240 minutes to obtain the golf club head. Thus, the golf club head with a Young's modulus higher than 119 GPa can be manufactured.
    Type: Application
    Filed: April 10, 2018
    Publication date: November 29, 2018
    Inventors: Chun-Fu Chang, Gen-Wei Jhou
  • Publication number: 20180340248
    Abstract: A method of making an alpha-beta titanium alloy is provided. The method includes forming a melt and solidifying the melt to form an ingot. The melt composition includes concentrations of Al from about 4.7 wt. % to about 6.0 wt. %; V from about 6.5 wt. % to about 8.0 wt. %; Si at less than 1 wt. %; Fe at up to about 0.3 wt. %; 0 at less than 1 wt. %; and a balance of Ti and incidental impurities. Furthermore, the Al/V ratio in the melt is equal to the concentration of the Al divided by the concentration of the V in weight percent is from about 0.65 to about 0.8.
    Type: Application
    Filed: August 2, 2018
    Publication date: November 29, 2018
    Applicant: Titanium Metals Corporation
    Inventors: Roger Owen Thomas, Paul Garratt, Matthew Thomas, Yoji Kosaka
  • Publication number: 20180340249
    Abstract: An alpha-beta titanium alloy is provided. The alpha-beta titanium alloy composition includes concentrations of Al from about 4.7 wt. % to about 6.0 wt. %; V from about 6.5 wt. % to about 8.0 wt. %; Si from about 0.15 wt. % to about 0.6 wt. %; Fe up to about 0.3 wt. %; O from about 0.15 wt. % to about 0.23 wt. %; Ti and incidental impurities as a balance. The alpha-beta titanium alloy may have a solution treated and aged microstructure and an elongation of at least about 10% at room temperature. Also, the alpha-beta titanium alloy may have an Al/V ratio from about 0.65 to about 0.8, the Al/V ratio being equal to the concentration of the Al divided by the concentration of the V in weight percent.
    Type: Application
    Filed: August 2, 2018
    Publication date: November 29, 2018
    Applicant: Titanium Metals Corporation
    Inventors: Roger Owen THOMAS, Paul GARRATT, Matthew THOMAS, Yoji KOSAKA
  • Publication number: 20180340250
    Abstract: An Al—Zn—Si—Mg alloy coated strip that has Mg2Si particles in the coating microstructure is disclosed. The distribution of Mg2Si particles is such that the surface of the coating has only a small proportion of Mg2Si particles or is at least substantially free of any Mg2Si particles.
    Type: Application
    Filed: December 20, 2017
    Publication date: November 29, 2018
    Inventors: Qiyang Liu, Wayne Renshaw, Joe Williams
  • Publication number: 20180340251
    Abstract: Components for an automatic motor vehicle transmission including a band brake drum, a clutch housing or hub having a seal surface or a clutch housing or hub utilized in a friction clutch assembly having a spline set. All of these components are fabricated of aluminum and the outer surface of the band brake drum, the housing or hub sealing surface and the area of the spline set includes a thin coating of a thermally sprayed steel material. The thermally sprayed steel material may be a low carbon steel such as SAE 1008 or 1010, a similar alloy, iron or other metal. The resulting components thus exhibit the weight saving of aluminum while providing excellent service life due to the enhanced strength and wear resistance provided by the thermally sprayed steel coating.
    Type: Application
    Filed: August 3, 2018
    Publication date: November 29, 2018
    Inventor: Scott William Heitzenrater
  • Publication number: 20180340252
    Abstract: A system and method for reducing attractive forces between a deposition mask and a substrate is provided that enables high-resolution direct deposition of a patterned layer of material on a substrate using electrostatic chucks for holding the substrate and the shadow mask. A charge-dissipating shadow mask is utilized that comprises a thin conductive layer on the surface of the membrane of the shadow mask. The conductive layer helps to dissipate the charge that accumulates on the membrane of the shadow mask, thereby reducing the attractive forces between the substrate and the shadow mask. As a result, the shadow mask and substrate can be placed in closer proximity to each other than would be possible without the charge-dissipating shadow mask, thereby reducing feathering effects and enabling higher resolution direct deposition.
    Type: Application
    Filed: May 24, 2018
    Publication date: November 29, 2018
    Inventors: Fridrich VAZAN, Evan P. DONOGHUE, Kerry TICE, Ilyas I. KHAYRULLIN, Tariq ALI, Qi WANG, Amalkumar P. GHOSH
  • Publication number: 20180340253
    Abstract: Designs and arrangements for sublimation cells are provided, which enriches an inert carrier gas with organic vapor such that the partial pressure of the organic vapor is highly stable in time. Stability is achieved by controlling the local rates of evaporation along the solid-gas interface through one or more crucibles, thereby reducing the effects of greater headspace and lowering interfacial area as the source depletes. Local evaporation rates also can be controlled using either temperature distribution or convective flow fields.
    Type: Application
    Filed: May 17, 2018
    Publication date: November 29, 2018
    Inventors: Gregory MCGRAW, Edwin VAN DEN TILLAART, William E. QUINN, Sven PEKELDER, Matthew KING
  • Publication number: 20180340254
    Abstract: A process for producing a coating source for physical vapour deposition provides the coating source with a target layer formed of an at least two-phase composite which contains a metallic phase and at least one further phase and a mechanical stabilizing layer which is joined to the target layer on one side of the target layer. A first powder mixture which corresponds in terms of its composition to the at least two-phase composite and a second powder mixture which corresponds in terms of its composition to the mechanical stabilizing layer are densified hot in superposed layers. A coating source for physical vapour deposition is also provided.
    Type: Application
    Filed: January 20, 2016
    Publication date: November 29, 2018
    Inventors: PETER POLCIK, SABINE WOERLE