Patents Issued in November 29, 2018
  • Publication number: 20180340905
    Abstract: A conductivity cell includes a cylindrical flow tube holder having a closed first end and an open second end, a first end fitting positioned on the first end of the flow tube holder, a second end fitting positioned on the second end of the flow tube holder, a flow tube positioned within the flow tube holder, an end cap positioned in the open second end of the flow tube holder and adjacent the flow tube and the second end fitting, a plurality of electrodes positioned in the flow tube, a plurality of o-rings positioned on the electrodes, and a flow through hole extending from the first end fitting through the flow tube holder, the flow tube, and the end cap to the second end fitting. The plurality of electrodes are press-fit into the flow tube.
    Type: Application
    Filed: May 24, 2017
    Publication date: November 29, 2018
    Inventors: Thomas Lenagh, Rudy Pitera, Tomas Lorincz
  • Publication number: 20180340906
    Abstract: A conductivity cell system includes a flow tube having a flow through hole extending from a first end of the flow tube to a second end of the flow tube, a plurality of electrodes positioned in the flow tube, and circuitry connected to the plurality of electrodes. The plurality of electrodes form pairs of electrodes, each pair consisting of two electrodes positioned across the flow tube from each other and being connected together.
    Type: Application
    Filed: May 24, 2017
    Publication date: November 29, 2018
    Inventors: Tomas Lorincz, Rudy Pitera, Thomas Lenagh
  • Publication number: 20180340907
    Abstract: Disclosed is a biological analyte monitoring device including a strip inserter in which a test strip is to be inserted, and a processor configured to read a code sequence based on an element detected from an index region, a first code region, and a second code region of the test strip in response to the test strip being inserted in the strip inserter, wherein the processor is further configured to determine a target interval in which an index element formed in the index region is detected while the test strip is being inserted in the strip inserter, detect a first code element formed in the first code region in the target interval and detect a second code element formed in the second code region in the target interval, and identify the code sequence based on a result of detecting the first code element and the second code element.
    Type: Application
    Filed: May 11, 2018
    Publication date: November 29, 2018
    Applicant: PHILOSYS CO., LTD.
    Inventor: In Hwan CHOI
  • Publication number: 20180340908
    Abstract: A meter is adapted for measuring concentrations of a chemical in a flowing solution. The meter has a barrier that shields a sensor from the high turbulence of the solution flow. One or more membranes can be employed to selectively filter out various ions or other chemicals.
    Type: Application
    Filed: August 2, 2018
    Publication date: November 29, 2018
    Inventor: Frederick Quincy Johnson
  • Publication number: 20180340909
    Abstract: In a gas sensor, a pump cell adjusts a concentration of oxygen in a gas chamber based of a pump cell supply voltage. A sensor cell detects a concentration of a specific gas in a detection target gas after the pump cell has adjusted the concentration of oxygen. In a sensor control unit, a voltage switching part adjusts the pump cell supply voltage to be supplied to the pump cell. A pump cell output control part adjusts a variation range of a pump cell output current of the pump cell before and after a voltage switching process of the pump cell supply voltage to be within a predetermined variation range. A deteriorated state detection part detects a deteriorated state ratio of the sensor cell based on variation of an output current of the sensor cell due to the voltage switching process performed by the voltage switching part.
    Type: Application
    Filed: May 24, 2018
    Publication date: November 29, 2018
    Inventors: Tadakatsu KOYABU, Tomoo KAWASE, Yuki MURAYAMA, Ryozo KAYAMA, Akari HASEGAWA, Shoki SHIMIZU
  • Publication number: 20180340910
    Abstract: The invention proposes a mass spectrometer comprising two ion mobility analyzers in tandem arrangement, of which at least one is a trapped ion mobility spectrometer (TIMS), and an ion gate which is located between the two ion mobility analyzers, and use thereof wherein ions are selectively transferred between the two ion mobility analyzers by adjusting the transmission of the ion gate while ions are separated in time according to ion mobility in the first ion mobility analyzer.
    Type: Application
    Filed: May 24, 2017
    Publication date: November 29, 2018
    Inventors: Thomas BETZ, Melvin Andrew PARK, Mark RIDGEWAY
  • Publication number: 20180340911
    Abstract: A magnetic field sensing system may include a first magnetic field sensing element; a second magnetic field sensing element; means for generating a first magnetic field having a first non-zero frequency; means for generating a second magnetic field having a second frequency; a conductive target positioned to generate a reflected magnetic field in response to the first magnetic field; means for producing a first signal representing the first magnetic field and the reflected magnetic field during a first alternating time period; means for producing a second signal representing the second magnetic field during a second alternating time period; means for calculating an error value as a function of the first and second signals, wherein the error value is based, at least in part, on the second signal during the first time period; and means for applying the error value to the first signal during the first alternating time period.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 29, 2018
    Applicant: Allegro MicroSystems, LLC
    Inventor: Hemán D. Romero
  • Publication number: 20180340912
    Abstract: A method for creating a pressure pulse in a fluid system with a noisemaker, the method includes opening a valve of the noisemaker to allow a fluid of the fluid system to flow through a valve cavity of the noisemaker, the valve disposed within the valve cavity, the noisemaker connected in fluid communication with the fluid system; closing the valve of the noisemaker to abruptly interrupt the flow of the fluid through the valve cavity; and repeatedly opening and closing the valve to generate a pulsating flow to the fluid system.
    Type: Application
    Filed: August 3, 2018
    Publication date: November 29, 2018
    Inventors: Valentin Mircea Burtea, Bruce Robertson
  • Publication number: 20180340913
    Abstract: There are proposed a method for measuring hydrogen-induced cracking which can measure hydrogen-induced cracking initiated in an interior of a test specimen during HIC test and a measuring apparatus used in this method. When cracks initiated in an interior of a test specimen 1 immersed in a test solution 5 containing hydrogen sulfide is measured by an ultrasonic probe 2 placed in a vessel 3, the position and size of cracks initiated in the interior of the test specimen 1 are measured with the lapse of time at a state of immersing the test specimen 1 in the test solution by scanning the ultrasonic probe 2 or the test specimen 1.
    Type: Application
    Filed: November 22, 2016
    Publication date: November 29, 2018
    Inventors: Daisuke Mizuno, Nobuyuki Ishikawa, Yutaka Matsui, Kyono Yasuda, Koji Fujimoto, Shigeaki Sugimoto
  • Publication number: 20180340914
    Abstract: A device according to an embodiment of the present invention for detecting an internal flaw in a steel plate by using a height-adjustable ultrasonic sensor may comprise: a spray nozzle installed a certain distance apart from the bottom of a steel plate, for spraying a medium toward the steel plate and forming a medium column; an ultrasonic sensor installed inside the spray nozzle, for transmitting and receiving ultrasonic waves for detecting flaws in the steel plate through the medium column; a flaw detecting unit for detecting the presence of internal flaws in the steel plate on the basis of the transmitted and received ultrasonic waves; and a driving unit installed inside the spray nozzle, for adjusting the distance between the ultrasonic sensor and the steel plate according to the thickness of the steel plate.
    Type: Application
    Filed: December 22, 2015
    Publication date: November 29, 2018
    Applicant: POSCO
    Inventors: Choong-Soo LIM, Hyeong Jun HUH, Hyun-Chul PARK, Sang-Jin LEE
  • Publication number: 20180340915
    Abstract: A gas chromatography (GC) column system includes an insulation tubing, a metallic GC column disposed within the insulation tubing and having an outer diameter that is less than or equal to an inner diameter of the insulation tubing, a first electrode in contact with the metallic GC column, and a second electrode in contact with the metallic GC column on an opposite side of the insulation tubing from the first electrode. The metallic GC column may be heated by applying a voltage across the first and second electrodes. The voltage may be controlled in response to a measured temperature of the metallic GC column.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 29, 2018
    Inventor: Yin Sun
  • Publication number: 20180340916
    Abstract: A method for monitoring a fluidic system of a liquid chromatography system is characterized by: (a) drawing a fluid into a syringe pump; (b) configuring a valve so as to fluidically couple the pump to either a fluidic pathway through the fluidic system or to a plug that prevents fluid flow; (c) causing the syringe pump to progressively compress the fluid therein or expel the fluid to the fluidic pathway, while measuring a pressure of the fluid; (d) determining a profile of the variation of the measured pressure; (e) comparing the determined profile to an expected profile that depends upon the fluid; and (f) providing a notification of a sub-optimal operating condition or malfunction if the determined profile varies from the expected profile by greater than a predetermined tolerance.
    Type: Application
    Filed: August 1, 2018
    Publication date: November 29, 2018
    Inventors: Tao SONG, John E. BRANN, Joseph John TAKAREWSKI, JR., Eric A. FRANCE
  • Publication number: 20180340917
    Abstract: A chromatography system with a main column comprising a chromatography resin, a first guard column and a second guard column, wherein the first guard column is connected to a first end of the main column, the second guard column is connected to a second end of the main column and the bed volumes of said first and second guard columns are each less than about 50% of the bed volume of the main column.
    Type: Application
    Filed: August 6, 2018
    Publication date: November 29, 2018
    Applicant: GE Healthcare Bio-Sciences AB
    Inventor: Karol Lacki
  • Publication number: 20180340918
    Abstract: When a column is attached to an attachment location, first, a ferrule through which the column is inserted is heated and thus is fixed to the column. Then, the column to which the ferrule is fixed is attached to the attachment location. As described, when a user performs work of attaching the column to the attachment location, the ferrule is always fixed to a certain spot of the column. Therefore, it is possible to omit work of holding the ferrule such that the position of the ferrule with respect to the column does not shift when the work of attaching the column is performed. As a result, the column can be easily attached to the attachment location.
    Type: Application
    Filed: May 22, 2018
    Publication date: November 29, 2018
    Applicant: SHIMADZU CORPORATION
    Inventor: Takero SAKAI
  • Publication number: 20180340919
    Abstract: A liquid chromatography (LC) column includes a wall having a length along a central axis from the inlet end to the outlet end, the wall enclosing a column interior and having a column radius relative to the central axis, the wall comprising a structured portion configured such that the column radius varies along the length; and a plurality of particles packed in the column interior, wherein at least some of the particles are in contact with the structured portion.
    Type: Application
    Filed: August 2, 2018
    Publication date: November 29, 2018
    Inventors: Hongfeng Yin, Reid A. Brennen, Eric Lyster, Roger Slocum
  • Publication number: 20180340920
    Abstract: A crescent PLOT column is disclosed, including a capillary column having an inlet, an outlet, a bore, and an inner surface surrounding the bore and extending between the inlet and the outlet. A layer of particles is localized on a radial portion of the inner surface. The layer of the particles includes a radial thickness decreasing from a center of the radial portion to a periphery of the radial portion, forming a crescent shape in a radial frame of reference. A method for preparing the crescent PLOT column is disclosed, including loading the capillary column with a fluid including a carrier and particles such that the fluid is contained within the capillary column. The capillary column and the fluid contained within the capillary column are subjected to a centrifugal force. The carrier is removed, and a layer of the particles is localized on the radial portion of the inner surface.
    Type: Application
    Filed: June 27, 2018
    Publication date: November 29, 2018
    Inventors: Jaap DE ZEEUW, William P. BROMPS, Tracey PETERS, Thomas E. KANE
  • Publication number: 20180340921
    Abstract: The invention discloses a device for identifying fluids or measuring their concentration. The device is configured to capture fluid sensing signals and sent to processing capabilities to be annotated, pre-processed and fed to databases of datasets and models which have learning capabilities. The device has a stick or stylus form factor which is makes it fit to be used by health care professionals or by the general public. Advantageously, the stick can be used to capture data from gas and liquid, being possibly phases of the same analyte. The device can be a package containing all processing capabilities being configured to be autonomous. It can operate in conjunction with an intermediary device of a smart phone, a PC or a POCT type. The system comprising autonomous fluid sensory devices, intermediary devices and database servers can operate in a learning mode or in a use mode.
    Type: Application
    Filed: February 23, 2016
    Publication date: November 29, 2018
    Applicant: ALPHA M.O.S
    Inventors: Chang-Hyun SHIM, Philippe BENEZECH, Sandrine ISZ, Jean-Christophe MIFSUD
  • Publication number: 20180340922
    Abstract: A dual-function heat indicator for monitoring two or more modes of heat exposure is described. A manufacturing process for the dual-function heat indicator is also described. Dual-function heat indicators as described may be useful for monitoring the exposure of host products, with which the dual-function heat indicators may be associated, to cumulative ambient heat exposure and to a peak ambient heat exposure, and for other purposes.
    Type: Application
    Filed: August 2, 2018
    Publication date: November 29, 2018
    Inventors: Thaddeus PRUSIK, Dawn E. SMITH, Dene H. TAYLOR, Mohannad ABDO
  • Publication number: 20180340923
    Abstract: A method for characterizing a brake fluid, the method comprising contacting a solvent with the brake fluid to provide a sample; introducing the sample into a first capillary column coated with a first stationary phase and allowing the sample to flow through the first capillary column to produce an effluent stream; and passing the effluent stream through a detector to identify one or more hydrocarbon components and optionally a detectable borate component, wherein the first capillary column is at a temperature effective for a borate ester in the sample, if any, to react with a portion of the solvent to form the detectable borate component.
    Type: Application
    Filed: May 23, 2017
    Publication date: November 29, 2018
    Inventors: Justin Pletzke, Shaelah M. Reidy
  • Publication number: 20180340924
    Abstract: Various embodiments of the invention include a system having: at least one computing device at least one computing device configured to monitor a lubrication oil by performing actions including: determining an initial ideal remaining life for the lubrication oil; determining a temperature-based remaining life for the lubrication oil based upon a temperature measurement of the lubrication oil; calculating a contamination factor of the lubrication oil based upon a non-particle count sample of the lubrication oil; determining an updated ideal life remaining for the lubrication oil based upon the contamination factor, the initial ideal remaining life, and the temperature-based remaining life; and determining an actual life remaining for the lubrication oil based upon the updated ideal life remaining and an actual life lost for the lubrication oil.
    Type: Application
    Filed: May 23, 2017
    Publication date: November 29, 2018
    Inventors: Hua Zhang, Seth Harmon Chapman, Keegan Saunders O'Donnell, Jan Terry Stover
  • Publication number: 20180340925
    Abstract: A sensor device includes a housing having a hole allowing substances to pass from an exterior of the housing to an interior of the housing, and a printed circuit board having a humidity sensor and at least one electronic component. The sensor device also includes a tube comprising a waterproof material, wherein a first end of the tube surrounds the humidity sensor, wherein a first seal is formed by between the first end of the tube and the printed circuit board, wherein a second end of the tube is located proximate the hole. The sensor device also includes a waterproof, breathable material layer disposed between the second end of the tube and the hole, wherein a second seal is formed between the material layer and the housing, wherein a third seal is formed between the material layer and the second end of the tube. The hole and the material layer allow water vapor to pass from the exterior to the humidity sensor.
    Type: Application
    Filed: August 1, 2018
    Publication date: November 29, 2018
    Inventors: Farrokh F. RADJY, Anousha RADJY
  • Publication number: 20180340926
    Abstract: The present invention provides methods for determining in a subject suffering from either type 1 diabetes mellitus or type 2 diabetes mellitus the risk of developing, and/or the rate of progression of certain diabetes associated complications (e.g., diabetic nephropathy and other associated disorders) resulting from angiopathic changes in the subject such as microvascular and/or macrovascular damage. The present invention also provides methods for handling, storing, and preserving, biological samples (e.g., blood, plasma, urine) from a subject having either Type 2 or Type 1 diabetes. Further provided are methods for analyzing biological samples from a subject to determine the quantities of one or more biomarkers of interest in comparison to results obtained from previous samples from the subject and/or to results obtained from aggregated samples, or to standards.
    Type: Application
    Filed: August 29, 2016
    Publication date: November 29, 2018
    Inventor: Paul J. Beisswenger
  • Publication number: 20180340927
    Abstract: In various embodiments, a metabolic urinary test core platform is disclosed. The core platform is adaptable into systems and methods for monitoring an individual's health. The core platform comprises a model; a physiologic fluid; a test panel; an instrument; and a computer, the computer further comprising program instructions written on a non-transient computer-readable media for performing a method of monitoring an individual's health. In certain aspects of the disclosure, the model comprises human individuals categorized into groups based on age and/or lifestyle, such as normal adult, workplace worker, elderly, athlete and dieter.
    Type: Application
    Filed: August 3, 2018
    Publication date: November 29, 2018
    Inventor: Andrew A. Dahl
  • Publication number: 20180340928
    Abstract: Described herein are fluorescent compounds and methods and comprising these compounds. The compounds disclosed herein are carbopyronine reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells.
    Type: Application
    Filed: June 7, 2018
    Publication date: November 29, 2018
    Inventors: Kyle Gee, Hee Chol Kang, Wenjun Zhou, Bradley Dubbels, Michael Olszowy, Michael O'Grady
  • Publication number: 20180340929
    Abstract: The invention described herein relates to methods of screening for pro-inflammatory genes and anti-inflammatory genes which may be useful for treating an inflammatory disease, disorder, or otherwise abnormal condition, such as an inflammatory lung disease. The identified pro-inflammatory genes and anti-inflammatory genes may be used to produce pharmaceutical compositions for use in treating the inflammatory disease, disorder, or otherwise abnormal condition.
    Type: Application
    Filed: April 27, 2018
    Publication date: November 29, 2018
    Applicant: The Jackson Laboratory
    Inventor: Wa Xian
  • Publication number: 20180340930
    Abstract: The present invention provides a cellular system for the detection of the presence of one or more antibody species in sample, preferably a serum or plasma sample. The method is in particular useful for the analysis of patients who have been sensitized against blood group antigens expressed on erythrocytes, platelets or granulocytes. The system uses fluorescence labeled cells specific for each antigen and hence, for each antibody species. Provided are the methods, system and diagnostic kits for performing the methods of the invention. In addition, the present invention discloses a method for removing antibodies from a sample such as a serum sample. Such a method is useful for absorbing antibodies from poly-agglutinating sera.
    Type: Application
    Filed: February 25, 2016
    Publication date: November 29, 2018
    Inventors: Halvard BOENIG, Christof GEISEN, Eliza Justyna WIERCINSKA, Nikolas RYSCHKA
  • Publication number: 20180340931
    Abstract: One aspect relates to a method of calibrating event data. The method includes obtaining, via an electronic device including a processor, event data for an assay including a reagent. The reagent is associated with one of a plurality of manufacturing lots of the reagent. The method includes receiving one or more calibration factors for the reagent based on an identifier associated with the one of the plurality of manufacturing lots. The method further includes generating calibrated event data based on an application of the one or more calibration factors to the event data.
    Type: Application
    Filed: March 22, 2018
    Publication date: November 29, 2018
    Inventors: Ramez Emile Necola Shehada, Oliver Crespo-Diaz, Paul Limb
  • Publication number: 20180340932
    Abstract: This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to test devices, e.g., cartridges, methods and systems, wherein the test devices have an entry port configured to receive a test sample into a holding chamber; a first conduit having at least one lateral flow test strip; and a displacement device, such as a pneumatic pump, configured to move a portion of said test sample from said holding chamber into said first conduit. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.
    Type: Application
    Filed: July 27, 2018
    Publication date: November 29, 2018
    Applicant: Abbott Point of Care Inc.
    Inventors: Pierre Emeric, Graham Davis, Thomas Ewart, Sergey Gershtein
  • Publication number: 20180340933
    Abstract: The invention relates to a compilation comprising at least five different peptides, each peptide comprising at least one sequence element corresponding to an epitope selected from the group consisting of SEQ ID NO.: 1-354, wherein at least five different epitopes are represented. The invention further relates to an in vitro method for determining a patient's immune status to soybean allergens, to a method for detecting at least one soybean allergen in a substance and to a method for determining the allergenicity of a soybean variety. Additionally, the invention relates to a kit comprising at least one composition containing a compound comprising at least five different sequence elements each corresponding to an epitope selected from the group consisting of SEQ ID NO.: 1-354, wherein at least five different epitopes are represented.
    Type: Application
    Filed: September 8, 2016
    Publication date: November 29, 2018
    Applicant: Fraunhofer-Gesellschaft zur Foerderung der angewan Forschung e.V.
    Inventors: Karolin Kern, Holger Spiegel, Heide Havenith, Michael Szardenings
  • Publication number: 20180340934
    Abstract: The present invention is directed to methods for detecting a melanoma, methods for determining whether a melanoma is stable or progressive, methods for evaluating the extent of surgery resection in a subject having a melanoma, and methods for determining a response by a subject having a melanoma to a therapy.
    Type: Application
    Filed: May 21, 2018
    Publication date: November 29, 2018
    Inventors: Irvin Mark Modlin, Mark Kidd, Ignat Drozdov
  • Publication number: 20180340935
    Abstract: The instant application relates to methods for determining pancreatic cancer patient outcome and directing treatment to subjects with pancreatic cancer. The present disclosure further provides methods for measuring expression levels of cytokeratin 17 in a subject having pancreatic cancer, such as pancreatic ductal adenocarcinoma, in order to determine the subject's survival rate and clinical outcome.
    Type: Application
    Filed: October 27, 2016
    Publication date: November 29, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Kenneth R. SHROYER, Luisa F. ESCOBAR-HOYOS
  • Publication number: 20180340936
    Abstract: Disclosed are a use of an ED-B protein as a tissue hyperplasia (such as tumor) marker, a method for detecting the ED-B protein, and a diagnostic kit comprising the ED-B protein. The kit of the present invention comprises a genetically-engineered antibody against the tumor marker ED-B.
    Type: Application
    Filed: November 16, 2015
    Publication date: November 29, 2018
    Applicant: HEFEI LIFEON PHARMACEUTICAL CO. LTD.
    Inventors: Junqiu Ji, Mei Zhang, Meihua Gao, Jun Chen
  • Publication number: 20180340937
    Abstract: The present invention relates to PI(4,5)P2 and more particularly to use of enzymes that metabolize and regulate the PI(4,5)P2 levels as a as a target for cancer treatment. Furthermore, measuring the level of PI(4,5)P2 or the degree of turnover of PI(4,5)P2 in cancer cells is an important diagnostic tool.
    Type: Application
    Filed: April 26, 2018
    Publication date: November 29, 2018
    Inventor: Christopher Janetopoulos
  • Publication number: 20180340938
    Abstract: This invention is a functionalized diamond crystal with high dispersibility in high ionic strength solution and/or with specific targeting ability, which comprise a diamond crystal and a fatty acid layer. The fatty acid layer works a surfactant and provides a specific targeting feature for the diamond crystal. The feature of the surfactant makes the diamond crystal being easily dispersed in biological surrounding (e.g., phosphate saline buffer) and the feature of specific targeting ability provides the diamond crystal with specific recognizing specific targets. This invention allows researchers to use diamond crystal as a marker for specific labelling.
    Type: Application
    Filed: May 25, 2018
    Publication date: November 29, 2018
    Inventors: Huan-Cheng CHANG, Feng-Jen HSIEH, Yen-Wei CHEN
  • Publication number: 20180340939
    Abstract: The present invention relates to methods for high multiplex protein or cellular constituent analysis in single cells or single isolated aggregations of cellular constituents. The methods provide for embedding cells or isolated aggregations of cellular constituents in a hydrogel mesh and labeling of cellular constituents with labeling ligands linked to a nucleic acid tag. Cellular constituents can be determined using sequencing methods.
    Type: Application
    Filed: October 27, 2016
    Publication date: November 29, 2018
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Jellert GAUBLOMME, Aviv REGEV
  • Publication number: 20180340940
    Abstract: Methods, devices, and systems are disclosed for performing high throughput analysis of conformational change in biological molecules or other biological entities using surface-selective nonlinear optical detection techniques.
    Type: Application
    Filed: April 27, 2018
    Publication date: November 29, 2018
    Inventors: Joshua Salafsky, Louis J. Dietz, Ray Hebert, Dar Bahatt
  • Publication number: 20180340941
    Abstract: In shotgun proteomics, generally only a fraction of peptides from a parent protein are actually detected. Because a large portion of the protein sequence is not detected, it is often impossible to determine whether the expressed protein is present in a modified, spliced, or truncated form. Provided herein are methods and systems for analyzing polypeptides which allow for the increase of the mean sequence coverage of a protein concomitant with bioinformatics analysis in order to distinguish putative proteoforms with improved amino acid resolution. Aspects of the invention include (1) a deep sequencing strategy to provide more protein sequence coverage than is typically achieved, and (2) a computational approach to view protein expression across its full length and identify regions of the protein that are potentially subject to such regulation. This technology has global utility in proteomics and will be of particular use for the analysis of biosimilar protein drug therapeutics.
    Type: Application
    Filed: May 24, 2018
    Publication date: November 29, 2018
    Inventors: Joshua COON, Harald MARX
  • Publication number: 20180340942
    Abstract: This disclosure relates to methods of culturing and characterizing antibody secreting cells. In certain embodiments, this disclosure relates to methods of isolating antibody secreting cells, e.g., long lived plasma cells, replicating the isolated cells in growth media disclosed herein, and determining the nucleic acids sequences in the cells that encode the produced antibodies.
    Type: Application
    Filed: May 30, 2018
    Publication date: November 29, 2018
    Inventors: Frances Eun-Hyung Lee, Ignacio Sanz, Doan C. Nguyen
  • Publication number: 20180340943
    Abstract: The present invention provides methods, compositions, and kits for the treatment and/or diagnosis of psoriasis. The invention includes a method for diagnosing psoriasis, comprising measuring a level or combination of levels of one or more of: IL-5, IL-6, IL-7, IL-10, IL-13, IL-33, FGF-B, GMCSF, VEGF, IL-33, MCP-1, or IP-10, or combinations thereof, in a sample from a patient; comparing said measured level or combination of levels; and correlating said level or combination of levels with a manifestation of psoriasis within said patient. A medicinal composition comprising an herbal combination of Da Huang, Sheng Di Huang, and Jin Yin Hua for the treatment of psoriasis in a patient. A kit for diagnosing and/or prognosing psoriasis in a patient.
    Type: Application
    Filed: November 23, 2016
    Publication date: November 29, 2018
    Inventors: Nadav SHRAIBOM, Anu T SINGH, Manu JAGGI, Eran STEINGERG, Ritu VERMA, Alka MADAAN
  • Publication number: 20180340944
    Abstract: Disclosed herein are isolated compositions including at least 2 of mutant peptides selected from the group consisting of SEQ ID NOS: 1-149, or polypeptides comprising the mutant peptides; wherein the composition comprises mutant peptides encoded by 2 or more genes. Also disclosed are methods for personalized treatment of breast cancer involving creating a peptide array of mutant peptides comprising the mutations in protein-encoding regions of the high-frequency cancer genes or the exome in a subject and screening the peptide array with a biological sample from the subject to detect antibodies in the biological sample that bind to the array, to detect antigenic targets for therapy in treating the subject.
    Type: Application
    Filed: May 25, 2018
    Publication date: November 29, 2018
    Inventors: David Han, Veneta Qendro
  • Publication number: 20180340945
    Abstract: The present invention relates to methods, compositions, and kits for detecting and quantitating biomarkers on vesicles without lysis or permeabilization of the vesicles and the use of biomarkers identified on vesicles in diagnostic and prognostic methods for various diseases and disorders. Disease and disorders of the present invention include neurological disorders, immunological disorders, placental diseases, and cancer.
    Type: Application
    Filed: May 24, 2018
    Publication date: November 29, 2018
    Inventor: Masato Mitsuhashi
  • Publication number: 20180340946
    Abstract: According to the inventive concept, a method of analyzing a biomaterial may include preparing an analysis apparatus including a substrate having a first region and a second region, supplying a second antigen onto the substrate to conduct a first reaction of a portion of antibodies and the second antigen, and conducting a second reaction of another portion of the antibodies and a first antigen after conducting the first reaction, to form a binding structure. The antibodies may be disposed in the first region of the substrate, the capturing structure may be provided in the second region of the substrate, and the capturing structure may include a linker which binds to the substrate and the first antigen which binds to the linker. The binding structure may include the linker, the first antigen and the antibody which binds to the first antigen.
    Type: Application
    Filed: January 15, 2018
    Publication date: November 29, 2018
    Inventors: Young Jun KIM, Wan Joong KIM, Eun Hye JANG, HyoYoung CHO
  • Publication number: 20180340947
    Abstract: The method of this invention relates a method of diagnosing a patient as having post-traumatic stress disorder (PTSD) and/or treating the patient therapeutically for PTSD. In one embodiment, the treatment involves administering a therapeutically effective amount of bufodienolide antagonist to the patient.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 29, 2018
    Inventor: Jules B. Puschett
  • Publication number: 20180340948
    Abstract: A device for agitating and collecting biological liquid samples comprises an agitator of racks of tubes and a sampling apparatus capable of collecting a biological liquid sample in a tube. The device also comprises a scheduler arranged to specify an order of sampling from the tubes independently of the order in which the tubes are positioned in the respective racks and the order in which the racks are inserted into the device. The scheduler is arranged to control the agitator and the sampling apparatus to process the tubes in accordance with the sampling order.
    Type: Application
    Filed: November 9, 2016
    Publication date: November 29, 2018
    Applicant: HORIBA ABX SAS
    Inventors: Sylvain ANDLAUER, Florent BEAUDUCEL, Philippe BENEZETH
  • Publication number: 20180340949
    Abstract: A method for operating a laboratory system comprising instruments for processing samples and a control unit connected by a communication network is presented. The method comprises receiving and identifying a biological sample and retrieving an order list from a database. The list comprises a plurality of targets defining one or more processing steps to be carried out on the biological sample by one or more of the laboratory instruments. The method also comprises selecting a workflow strategy and retrieving workflow acceptance criterion corresponding to the workflow strategy. The control unit determines a sample workflow for processing the sample based on the workflow strategy and determines whether the sample workflow satisfies the workflow acceptance criterion. If the sample workflow does not satisfy the workflow acceptance criterion, workflow strategy and the workflow acceptance criterion is refined and the sample workflow is determined again until it satisfies the workflow acceptance criterion.
    Type: Application
    Filed: May 22, 2018
    Publication date: November 29, 2018
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Marco Maetzler, Christopher Schofield, Ole Lambaek, Moritz von Hopffgarten
  • Publication number: 20180340950
    Abstract: A rotating disc type fecal occult blood detection analyzer is used for detecting sample boxes (16). A sample box (16) comprises a transparent sleeve, and a fecal collector and a test strip provided in the transparent sleeve. The rotating disc type fecal occult blood detection analyzer comprises: a disc-shaped sample box holder (17) carrying multiple sample boxes (16); a driving device for driving the sample box holder (17) to rotate; a pressing device for pressing the sample boxes (16) down; and an information collecting device for collecting color ribbon information presented on the test strips in the sample boxes (16) and label information on the sample boxes (16). The rotating disc type fecal occult blood detection analyzer is small in size and compact in structure It is portable and makes detection more flexible.
    Type: Application
    Filed: September 29, 2016
    Publication date: November 29, 2018
    Applicant: W.H.P.M BIORESEARCH AND TECHNOLOGY CO., LTD.
    Inventors: John WAN, Zejiang LI, Qingwei SHEN
  • Publication number: 20180340951
    Abstract: A transport device for a laboratory sample distribution system is presented. The transport device comprises a plurality of electro-magnetic actuators and a driving surface arranged above the actuators, in which the driving surface is configured to carry sample container carriers. The driving surface is tiled and comprises a plurality of driving surface modules with driving surface elements. Support elements arranged in a grid pattern are provided. Each driving surface module is detachably mounted to a subset of the support elements. A laboratory sample distribution system and to a laboratory automation system comprising a laboratory sample distribution system are also presented.
    Type: Application
    Filed: August 2, 2018
    Publication date: November 29, 2018
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Marcel Kaeppeli, Tobias Huber, Pius Hermann, Matthias Edelmann
  • Publication number: 20180340952
    Abstract: A transport device for a laboratory sample distribution system is presented. The transport device comprises a plurality of actuator modules. Each actuator module comprises a plurality of electro-magnetic actuators. A plurality of base plate modules arranged in a pattern is provided. The base plate modules are coupled to each other and aligned by support elements. The number of base plate modules at least equals the number of actuator modules and each base plate module is configured to support one of the plurality of actuator modules. A laboratory sample distribution system and to a laboratory automation system comprising a laboratory sample distribution system are also presented.
    Type: Application
    Filed: August 2, 2018
    Publication date: November 29, 2018
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Marcel Kaeppeli, Tobias Huber, Pius Hermann, Matthias Edelmann
  • Publication number: 20180340953
    Abstract: A specimen processing apparatus may include: an aspirating tube configured to aspirates a specimen in automatic aspiration and manual aspiration; an aspirating tube moving mechanism configured to move the aspirating tube between a first region in which the automatic aspiration is performed and a second region in which the manual aspiration is performed, the first region covered with a wall, the second region separated from the first region; and a processing unit that processes the specimen aspirated by the aspirating tube.
    Type: Application
    Filed: May 22, 2018
    Publication date: November 29, 2018
    Applicant: SYSMEX CORPORATION
    Inventor: Yuuichi HAMADA
  • Publication number: 20180340954
    Abstract: A rotation speed detection device includes a blade detection sensor located in a housing of a turbocharger and that outputs an output voltage that fluctuates according to an approaching of a blade of a compressor wheel to the blade detection sensor and a separation of the blade from the blade detection sensor, and a sensor circuit to binarize an output signal of the blade detection sensor into a high signal and a low signal and to output the signals. The sensor circuit includes a low pass filter to cut off a high frequency component of the output signal by an analog filter or a digital filter, a high pass filter to cut off a low frequency component of the output signal by a digital filter, and a control unit to increase a cut-off frequency of the high pass filter in accordance with an increase in rotation speed of the turbocharger.
    Type: Application
    Filed: September 21, 2016
    Publication date: November 29, 2018
    Inventor: Hirotsugu ISHINO