Patents Issued in January 15, 2019
  • Patent number: 10179733
    Abstract: An underwater hydrogen generator can include a watertight reaction housing enclosing a metering chamber. The metering chamber can have an upper portion that terminates at a piston opening, and a lower portion that merges into a funnel, which can further terminate at a metering opening. The metering chamber can be filled with an acid accelerator, and the watertight reaction void can be partially filled with NaBH4 in solution. The generator can further include a seawater float valve that can be in fluid communication between the external environment, the metering chamber and the void defined by the reaction housing. The float valve, metering chamber and reaction housing can cooperate to generate hydrogen when said generator is submerged, by allowing seawater to contact both the acid accelerator and the NaBH4. The size of the metering opening can determine the rate at which acid accelerator is added to the NaBH4 solution.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: January 15, 2019
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Carol A. Becker, Wayne E. Glad, Brandon J. Wiedemeier
  • Patent number: 10179734
    Abstract: A fuel supply apparatus comprising; a reaction chamber for hosting a reaction when a fuel generating fluid and a fuel generating substance are brought together to generate fuel, a plurality of discrete fuel generating fluid chambers, each chamber being separately rupturable; and, a heater assembly adapted to, when in use, selectively rupture the fuel generating fluid chambers to supply fuel generating fluid to the reaction chamber.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: January 15, 2019
    Assignee: INTELLIGENT ENERGY LIMITED
    Inventor: Harry John Karmazyn
  • Patent number: 10179735
    Abstract: Impure gaseous hydrogen chloride from organochlorosilane hydrolysis is freed of impurities by first scrubbing with an organochlorosilane, which may be the same or different from the organochlorosilane(s) hydrolyzed, and then further scrubbing with chloromethane. The purified gaseous hydrogen chloride is preferably used in chlorosilane synthesis.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: January 15, 2019
    Assignee: WACKER CHEMIE AG
    Inventor: Konrad Mautner
  • Patent number: 10179736
    Abstract: Disclosure relates to modified sulfur, preparation method thereof, preparation equipment thereof. The modified sulfur has spinnability or includes micro-structures such as fiber-, film- and network-like structure. The modified sulfur can be prepared by inducing polymerization with ultrasonic or ageing. The modified sulfur has various excellent features such as anticorrosiveness, waterproofing, strength, and fast drying and can control the features depending on its viscosity or polymerization degree. In addition due to the above features, the modified sulfur can be applied to anticorrosive or waterproofing material and can prepare anticorrosive or waterproofing material which has good workability, hardening, salt spray resistance, and weldability exceeding a certain level, and specially improved adhesiveness.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: January 15, 2019
    Assignee: Korea Institute of Science and Technology
    Inventors: Goo Dae Kim, No Gyung Park, Hyok Kwon, Young Sik Seo, Seung Gun Yu, Hyuk Rae Noh
  • Patent number: 10179737
    Abstract: Provided are spherical silicon oxycarbide particle material and manufacturing method thereof, wherein the average particle size is in the range of 0.1-100 ?m and having a sphericity of 0.95-1.0. Spherical silicon oxycarbide particle material and manufacturing method thereof are provided as follows. Organotrialkoxysilane is hydrolyzed in a pH 3-6 acetic acid aqueous solution, thereafter an alkaline aqueous solution such as a pH 7-12 ammonia water was added to the obtained hydrolysate. The condensation reaction is performed in an alkaline range to form spherical polysilsesquioxane particles that are spherical silicon oxycarbide precursors that has no melting point or softening point. Sintering was then performed at a sintering temperature of 600-1400° C. under inert atmosphere to obtain spherical silicon oxycarbide particle material.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: January 15, 2019
    Assignee: JNC CORPORATION
    Inventors: Tetsuro Kizaki, Keizo Iwatani
  • Patent number: 10179738
    Abstract: A method for preparing multi-wall carbon nanotubes comprising atomizing a precursor solution comprising an aromatic hydrocarbon and a carrier gas. The mixture is then injected through an ultrasonic atomization system to form atomized precursor droplets. Then by injecting the atomized precursor droplets from the top of a vertical chemical vapor deposition reactor, the droplets can then react with a reaction gas in the reactor vessel to form a film that adsorbs to a growth surface in the reactor vessel. Layer by layer multi-wall carbon nanotubes are formed. This method is repeated to form layers of the multi-wall carbon nanotubes. The nanotubes formed have an outer diameter of 10 nm-51 nm and a length to diameter aspect ratio of 7200-13200.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: January 15, 2019
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Zuhair Omar Malaibari, Muataz Ali Atieh, Fahad Ali Rabbani
  • Patent number: 10179739
    Abstract: A method for preparing multi-wall carbon nanotubes comprising atomizing a precursor solution comprising an aromatic hydrocarbon and a carrier gas. The mixture is then injected through an ultrasonic atomization system to form atomized precursor droplets. Then by injecting the atomized precursor droplets from the top of a vertical chemical vapor deposition reactor, the droplets can then react with a reaction gas in the reactor vessel to form a film that adsorbs to a growth surface in the reactor vessel. Layer by layer multi-wall carbon nanotubes are formed. This method is repeated to form layers of the multi-wall carbon nanotubes. The nanotubes formed have an outer diameter of 10 nm-51 nm and a length to diameter aspect ratio of 7200-13200.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: January 15, 2019
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Zuhair Omar Malaibari, Muataz Ali Atieh, Fahad Ali Rabbani
  • Patent number: 10179740
    Abstract: The invention relates to a new phase of silicon, Si24, and a method of making the same. Si24 has a quasi-direct band gap, with a direct gap value of 1.34 eV and an indirect gap value of 1.3 eV. The invention also relates to a compound of the formula Na4Si24 and a method of making the same. Na4Si24 may be used as a precursor to make Si24.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: January 15, 2019
    Assignee: CARNEGIE INSTITUTION OF WASHINGTON
    Inventors: Timothy A. Strobel, Duck Young Kim, Oleksandr O. Kurakevych
  • Patent number: 10179741
    Abstract: A process for the post-treatment of a zeolitic material having a BEA framework structure, the process comprising (i) providing a zeolitic material having a BEA framework structure, wherein the framework structure of the zeolitic material comprises X2O3 and YO2, wherein Y is a tetravalent element and X is a trivalent element and wherein the molar ratio X2O3:YO2 is greater than 0.02:1; (ii) treating the zeolitic material provided in (i) with a liquid solvent system thereby obtaining a zeolitic material having a molar ratio X2O3:YO2 of at most 0.02:1, and at least partially separating the zeolitic material from the liquid solvent system; (iii) treating the zeolitic material obtained from (ii) with a liquid aqueous system having a pH in the range of 5.5 to 8 and a temperature of at least 75° C.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: January 15, 2019
    Assignee: BASF SE
    Inventors: Andrei-Nicolae Parvulescu, Jeff Yang, Stefan Maurer, Manuela Gaab, Karsten Seidel, Olga Gerlach, Ulrich Mueller
  • Patent number: 10179742
    Abstract: A method of filtering fluid for injection into an injection well comprises detecting a fluid pressure in a conduit upstream of an actuator valve, verifying that the fluid pressure is within an operating pressure range, opening an actuator valve based on the verifying, receiving a fluid having suspended solids within a filter assembly in response to opening the actuator valve, actuating a pump in fluid communication with the filter assembly based on receiving the fluid within the filter assembly, and separating at least a portion of the suspended solids in the fluid within the filter assembly.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: January 15, 2019
    Inventor: Eric Benavides
  • Patent number: 10179743
    Abstract: A device for controlling injection of chemical into a boiler and a chemical injection method can control an injection amount such that a chemical concentration is obtained as per a target even in a boiler feed-water facility where a flow rate of feed-water varies to a large extent in a short period. The device controls an amount discharged by a chemical injection pump in proportion to a flow rate measured by a flowmeter. An average chemical concentration in a feed-water is calculated from an amount of feed-water per predetermined period obtained by the flowmeter and a reduction in the amount of chemical in a tank per predetermined period obtained by a sensor. The chemical injection pump is controlled on the basis of the calculated average chemical concentration and a preset target chemical concentration of the feed-water so that the average chemical concentration is within the target chemical concentration range.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: January 15, 2019
    Assignee: KURITA WATER INDUSTRIES LTD.
    Inventors: Chikako Shimpo, Yukimasa Shimura
  • Patent number: 10179744
    Abstract: A method to remediate water includes preparing a microbial solution with microbes, a growth medium, and water; iteratively and selectively breeding generations of microbes to arrive at a predetermined microbial solution in a highly concentrated form of at least 1×109 cfu/ml (colony-forming units per milliliter); and dispensing the microbial solution into the water, wherein the microbes metabolizes excess nutrients and uses microbial desalination to reduce water salinity.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: January 15, 2019
    Assignee: Cisbay Global Inc.
    Inventor: Khanh Le
  • Patent number: 10179745
    Abstract: A water recovery system can treat water in a confined space. The wastewater treatment system includes a cation-exchange device in which water to be treated, such as wastewater originating in a space station, water discharged by the human body, water produced by condensing water vapor contained in the air, is directly introduced to a cation-exchange resin and thereby treated by cation exchange; a diamond-electrode electrolysis device in which organic substances, urea, and other nitrogen compounds contained in water discharged from the cation-exchange device are decomposed; a catalytic decomposition device in which the residual organic component is brought into contact with a catalyst to be decomposed; an electrodialysis device in which water discharged from the catalytic decomposition device is treated by electrodialysis to produce desalted water as well as an acid and an alkali; and a mineral adding device in which a mineral is added to the desalted water.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: January 15, 2019
    Assignee: KURITA WATER INDUSTRIES LTD.
    Inventors: Yukitaka Matsumoto, Nobuhiro Orita, Hideki Kobayashi
  • Patent number: 10179746
    Abstract: Disclosed are methods and machines for removing volatile compounds from sludge. Additionally, disclosed are methods and machines for removing pathogens from sludge.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: January 15, 2019
    Inventor: Richard Murray Hough
  • Patent number: 10179747
    Abstract: A cover window manufacturing apparatus includes a plurality of fixed plates, a plurality of moving plates, a plurality of molds and a driver. The plurality of fixed plates is layered and spaced apart at a distance from each other. The plurality of moving plates is layered, spaced apart at a distance from each other and respectively disposed under the plurality of fixed plates. A plurality of connection members integrally connects the plurality of moving plates with each other. The plurality of molds is respectively provided on the plurality of moving plates, and inner spaces for molding the cover window are respectively defined in the plurality of molds. The driver is coupled to one of the plurality of moving plates, and is configured to move the plurality of moving plates towards the plurality of fixed plates such that the plurality of molds are pressed to the plurality of fixed plates.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: January 15, 2019
    Assignee: SAMSUNG DISPLAY CO., LTD.
    Inventor: Moon-Seok Roh
  • Patent number: 10179748
    Abstract: A method of laser processing a material to form a separated part. The method includes focusing a pulsed laser beam into a laser beam focal line, viewed along the beam propagation direction, directed into the material, the laser beam focal line generating an induced absorption within the material, the induced absorption producing a hole or fault line along the laser beam focal line within the material, and directing a defocused carbon dioxide (CO2) laser from a distal edge of the material over the plurality of holes to a proximal edge of the material.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: January 15, 2019
    Assignee: Corning Incorporated
    Inventors: Sasha Marjanovic, Garrett Andrew Piech, Sergio Tsuda, Robert Stephen Wagner
  • Patent number: 10179749
    Abstract: A low-temperature co-fired ceramic material comprises the following components in percentage by weight: 35-50% of CaO, 5-15% of B2O3, 40-55% of SiO2, 1-5% of nanometer Al2O3, 1-5% of MgO and 1-5% of nanometer ZrO2. A preparation method comprises the following steps: ball milling and mixing according to the formula, sintering at a high temperature, quenching in deionized water, grinding, performing wet ball-milling, drying and grinding; and finally, granulating to prepare a green body, discharging glue, and sintering, to obtain a low-temperature co-fired ceramic material. According to the low-temperature co-fired ceramic material and the preparation method thereof provided in the present disclosure, the prepared low-temperature co-fired ceramic material has the advantages of low dielectric constant, low loss, good overall performance and the like.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: January 15, 2019
    Assignee: Shenzhen Sunlord Electronics Co., Ltd.
    Inventors: Jian Liu, Min Nie
  • Patent number: 10179750
    Abstract: The present invention discloses a preparation method of a polycarboxylate superplasticizer with carbon dioxide, comprising the following steps: (1) preparing a polycarboxylate superplasticizer prepolymer: performing an oxidation-reduction radical polymerization of an unsaturated macromonomer, an unsaturated phenol derivative, a reducing agent, an initiator and a chain transfer agent with different proportions under a nitrogen atmosphere to obtain a novel polycarboxylate superplasticizer prepolymer with different molecular weight; adjusting the pH by adding an alkali; (2) preparing a polycarboxylate superplasticizer: performing a Koble-Schmitt reaction between the polycarboxylate superplasticizer prepolymer and a carbon dioxide for a certain time to obtain the polycarboxylate superplasticizer.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: January 15, 2019
    Assignee: JIANGSU ARIT NEW MATERIALS CO., LTD.
    Inventors: Shanshan Qian, Zhaolai Guo, Chunyang Zheng, Chunman Huang, Haidong Jiang, Gaoming Wang, Yi Wang, Mengting Li, Ying Qiu, Jiezhong Gan
  • Patent number: 10179751
    Abstract: A process for producing an ammonia-treated hydrophilic thermal insulation molding which includes treating a thermal insulation molding containing hydrophilic silica with ammonia by introducing the thermal insulation molding into a chamber and supplying gaseous ammonia until a pressure difference ?p of ?20 mbar is achieved. A process for producing a thermal insulation molding containing hydrophobic silica which includes treating the ammonia-treated hydrophilic thermal insulation molding with an organosilicon compound.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: January 15, 2019
    Assignee: Evonik Degussa GmbH
    Inventors: Matthias Geisler, Frank Menzel
  • Patent number: 10179752
    Abstract: The present invention relates to a 1-octene composition. The 1-octene composition according to the present invention is prepared by ethylene oligomerization and comprises a high content of 1-octene and monomers useful for copolymerization of 1-octene at the same time.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: January 15, 2019
    Assignee: LG CHEM, LTD.
    Inventors: Yong Ho Lee, Seok Pil Sa, Eun Ji Shin, Ki Soo Lee, Jin Young Park, Seul Ki Im, Yoon Ki Hong
  • Patent number: 10179753
    Abstract: Methods of simultaneously converting butanes and methanol to olefins over Ti-containing zeolite catalysts are described. The exothermicity of the alcohols to olefins reaction is matched by endothermicity of dehydrogenation reaction of butane(s) to light olefins resulting in a thermo-neutral process. The Ti-containing zeolites provide excellent selectivity to light olefins as well as exceptionally high hydrothermal stability. The coupled reaction may advantageously be conducted in a staged reactor with methanol/DME conversion zones alternating with zones for butane(s) dehydrogenation. The resulting light olefins can then be reacted with iso-butane to produce high-octane alkylate. The net result is a highly efficient and low cost method for converting methanol and butanes to alkylate.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: January 15, 2019
    Assignee: Exelus, Inc.
    Inventors: Mitrajit Mukherjee, Vamsi M. Vadhri, Narendra Joshi
  • Patent number: 10179754
    Abstract: The present invention relates to a process for isomerizing a C3-7 (hydro)(halo)fluoroalkene comprising (a) providing a reactor feed stream comprising the C3-7 (hydro)(halo)fluoroalkene; and (b) contacting the C3-7 (hydro)(halo)fluoroalkene with a catalyst comprising alumina to isomerize the C3-7 (hydro)(halo)fluoroalkene, wherein the catalyst has a sodium content of less than about 800 ppm.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: January 15, 2019
    Assignee: MEXICHEM AMANCO HOLDING S.A. de C.V.
    Inventors: Claire E McGuinness, Andrew P Sharratt
  • Patent number: 10179755
    Abstract: A method for preparing a branched alcohol by dimerizing an aliphatic monoalcohol having three or more carbon atoms in the presence of a base and a catalyst. The dimerization reaction is performed under atmospheric pressure while injecting a hydrogen gas. With this method, it is possible to obtain a dimerized alcohol with excellent yield even when using a branched aliphatic monoalcohol as the starting material.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: January 15, 2019
    Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, NISSAN CHEMICAL INDUSTRIES, LTD.
    Inventors: Hajime Kawanami, Takayuki Ishizaka, Hitomi Fujiyama, Nobuyuki Kakiuchi, Norihito Shiga
  • Patent number: 10179756
    Abstract: A process of oxidizing an alcohol for the production of its corresponding carbonyl compounds is disclosed, wherein the oxidation is performed with oxygen or gases containing oxygen in the presence of a catalyst comprising at least a gold compound and a copper compound. Said alcohol oxidation by gaseous oxidant can achieve a high yield and selectivity with minimized degradation products or waste organic solvents.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: January 15, 2019
    Assignees: RHODIA OPERATIONS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Wenjuan Zhou, Wenhao Fang, Armin T. Liebens
  • Patent number: 10179757
    Abstract: The invention relates to a process for obtaining a formate from a reaction mixture (10) in which a polyoxometallate ion, which acts as a catalyst, is in contact with an organic material at a temperature below 120° C. to produce formic acid in an aqueous solution, with the following steps: a) separating a mixture of formic acid and water from the reaction mixture by reverse osmosis and/or as vapor (18), the vapor (18) subsequently being condensed, and b) reacting the formic acid with a hydroxide (24) in aqueous solution to produce a solution of a formate.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: January 15, 2019
    Assignee: JBACH GMBH
    Inventors: Hermann Wolf Jbach, Carmen Platten, Gunthard Scholz, Andreas Bösmann
  • Patent number: 10179758
    Abstract: A method for crystallizing succinic acid includes agitating a succinic acid reaction solution with a jet-flow agitator that is rotated at low speed and has a low volume power density; compared with the conventional agitators, the jet-flow agitator helps increase the uniformity of succinic acid particles, shorten the time required for crystallizing succinic acid, and raise the yield of the crystallized succinic acid as well as purity of crystallized succinic acid having a purity of 99.8-99.9%.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: January 15, 2019
    Assignee: NAN YA PLASTICS CORPORATION
    Inventors: Te-Chao Liao, Jung-Jen Chuang, Cheng-Hsun Chen, Chia-Ruey Tsai, Chung-Yu Chen
  • Patent number: 10179759
    Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which comprises: (a) purifying the feed mixture in a first chromatographic separation step using an eluent a mixture of water and a first organic solvent, to obtain an intermediate product; and (b) purifying the intermediate product in a second chromatographic separation step using as eluent a mixture of water and a second organic solvent, to obtain the PUFA product, wherein the second organic solvent is different from the first organic solvent and has a polarity index which differs from the polarity index of the first organic solvent by between 0.1 and 2.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: January 15, 2019
    Assignee: BASF Pharma (Callanish) Limited
    Inventors: Adam Kelliher, Angus Morrison
  • Patent number: 10179760
    Abstract: A method of obtaining purified DMF from a mixture comprising DMF and hydrogen chloride (HCl) involving distillation is provided.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: January 15, 2019
    Assignee: Tate & Lyle Technology Limited
    Inventors: Thomas Eilers, David A. Dentel, Halil Aktas
  • Patent number: 10179761
    Abstract: The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: January 15, 2019
    Assignees: UNIVERSITE DE LILLE 2 DROIT ET SANTE, CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)
    Inventors: Patricia Melnyk, Patrick Vermersch, Pascal Carato, Bénédicte Oxombre-Vanteghem, Hélène Zephir, Marion Donnier-Marechal
  • Patent number: 10179763
    Abstract: There is provided a method for producing an oxide catalyst, the method including a step (a) of obtaining an aqueous mixed liquid A containing Mo, V and Sb, a step (b) of mixing a Nb raw material, water and an organic acid to obtain a Nb aqueous solution, a step (c) of mixing the Nb aqueous solution and a silica raw material to obtain an aqueous mixed liquid B, a step (d) of mixing the aqueous mixed liquid A and the aqueous mixed liquid B to obtain an aqueous mixed liquid (C), a step (e) of drying the aqueous mixed liquid C to obtain a dried powder D, and a step (f) of calcining the dried powder D to obtain the oxide catalyst.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: January 15, 2019
    Assignee: ASAHI KASEI KABUSHIKI KAISHA
    Inventors: Yusuke Ishii, Kazushi Okada
  • Patent number: 10179764
    Abstract: The present invention relates to a novel compound showing leukotriene B4 receptor 2 (BLT2) inhibitory activity and a pharmaceutical composition, for preventing or treating inflammatory diseases, having same as an active ingredient. The inventors identified a novel compound containing BTL2 inhibitory activity, and experimentally confirmed that the present novel compound had an excellent effect on the enhancement of the cancer cell death, on the inhibition of the metastasis and chemotactic mobility, and on the anti-asthma activity. Therefore, the present novel compound can be used as a very effective pharmaceutical component for treating the inflammatory-related diseases.
    Type: Grant
    Filed: July 23, 2016
    Date of Patent: January 15, 2019
    Assignees: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Yongseok Choi, Jae-Hong Kim, Kyeong Lee, Hyo-Kyung Han, Jun Dong Wei, Jinsun Kwon, Ja-Il Goo
  • Patent number: 10179765
    Abstract: The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: January 15, 2019
    Assignees: Cardioxyl Pharmaceuticals, Inc., The Johns Hopkins University
    Inventors: John P. Toscano, Frederick Arthur Brookfield, Andrew D. Cohen, Stephen Martin Courtney, Lisa Marie Frost, Vincent Jacob Kalish
  • Patent number: 10179766
    Abstract: A thiol group-containing polymer represented by: HS—(R—Sr)n—R—SH wherein R is an organic group including a —O—CH2—O— bond and a branched alkylene group, n is an integer of from 1 to 200, r is an integer of from 1 to 5, an average value of r is 1.1 or more and lower than 1.8, and the thiol group-containing polymer is a liquid at room temperature and has a specific gravity at 23° C. of 1.20 to 1.27.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: January 15, 2019
    Assignee: Toray Fine Chemicals Co., Ltd.
    Inventors: Koki Echigoya, Yukiko Hamada, Kazunori Matsumoto
  • Patent number: 10179767
    Abstract: The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: January 15, 2019
    Assignees: GENENTECH, INC., XENON PHARMACEUTICALS INC.
    Inventors: Sultan Chowdhury, Christoph Martin Dehnhardt, Abid Hasan, Ivan William Hemeon, Qi Jia, Jun Li, Zhiguo Liu, Daniel F. Ortwine, Brian Safina, Daniel Sutherlin, Shaoyi Sun, Andrew D. White, Wei Gong, Alla Yurevna Zenova, Jiuxiang Zhu
  • Patent number: 10179768
    Abstract: The present invention relates to a group of novel electrochromic materials. More specifically, it relates to electrochromic materials having two-core viologens and the use of these two-core viologens as a variable transmittance medium for the manufacture of an optical article, such as an ophthalmic lens.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: January 15, 2019
    Assignee: ESSILOR INTERNATIONAL
    Inventors: Stuart Aiken, Daniel Luke Crossley, Christopher David Gabbutt, Bernard Mark Heron, Claudine Biver, Samuel Archambeau, Fabien Berit-Debat
  • Patent number: 10179769
    Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: January 15, 2019
    Assignee: Celgene Quanticel Research, Inc.
    Inventors: Young K. Chen, Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
  • Patent number: 10179770
    Abstract: The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and non-neoplastic diseases.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 15, 2019
    Assignee: GENOSCIENCE PHARMA
    Inventors: Jerome Courcambeck, Philippe Halfon, Firas Bassissi, Sonia Brun, Gregory Nicolas, Antoine Beret, Serge Petit, Claire Camus, Jean Pierre Nallet
  • Patent number: 10179771
    Abstract: The present invention discloses compounds according to Formula I: wherein Cy, R1, L1, R3, R4, R5, La, and Ra are as defined herein. Novel benzimidazoles according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic diseases, inflammatory diseases, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or hypersecretion of interferons.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: January 15, 2019
    Assignee: GALAPAGOS NV
    Inventors: Christel Jeanne Marie Menet, Oscar Mammoliti, Javier Blanc, Mislav Orsulic, Maja Roscic
  • Patent number: 10179772
    Abstract: The invention relates to an improved process for the manufacture of bis-resorcinyl triazines of formula (I), wherein R1 is hydrogen, a C1-C18 alkyl group or a C2-C18 alkenyl group and R2 is a C1-C18 alkyl group or a C2-C18 alkenyl group.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: January 15, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Nadine Greiner, Sandro Schmid, René Tobias Stemmler
  • Patent number: 10179773
    Abstract: The present disclosure provides substituted isoxazole carboxamides having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, X, n, and m are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: January 15, 2019
    Assignee: EPIZYME, INC.
    Inventors: Richard Chesworth, Megan Alene Cloonan Foley, Kevin Wayne Kuntz, Lorna Helen Mitchell, Jennifer C. Petter, Carl Eric Schwartz
  • Patent number: 10179774
    Abstract: Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: January 15, 2019
    Assignee: Knopp Biosciences LLC
    Inventors: Prasad Raje, Rajendrakumar Reddy Gadikota, Jian-Xie Chen, Olga V. Lapina, John M. McCall
  • Patent number: 10179775
    Abstract: This disclosure relates to trans-cyclooctene compounds and methods of using the same in bioorthogonal labeling experiments.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: January 15, 2019
    Assignee: The General Hospital Corporation
    Inventors: Scott A. Hilderbrand, Balazs R. Varga, Ralph Weissleder
  • Patent number: 10179776
    Abstract: The invention relates to particular 2-((1-(2-hydroxy-2-phenylethyl)piperidin-4-yl)methyl)isoindolin-1-one analogs and pro-drugs, in free, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases that can be therapeutically and/or preventively treated by the nerve control function of sigma ligands.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: January 15, 2019
    Assignee: INTRA-CELLULAR THERAPIES, INC.
    Inventors: Robert Davis, Peng Li
  • Patent number: 10179777
    Abstract: Compounds of the formula I in which W, R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of ALK1, AL2 and ALK5, and can be employed for the treatment of diseases such as cancer.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: January 15, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Alfred Jonczyk, Mireille Krier
  • Patent number: 10179778
    Abstract: Acid generators comprising a carbocyclic or heteroaromatic group substituted with at least one diester moiety are provided. These acid generators are particularly useful as a photoresist composition component.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: January 15, 2019
    Assignee: Rohm and Haas Electronic Materials LLC
    Inventor: Paul J. LaBeaume
  • Patent number: 10179779
    Abstract: The present invention relates to novel crystal forms of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2H-pyran-4-carboxylic acid. More particularly, the invention relates to polymorph forms of Polymorph Form I, Polymorph Form II, Polymorph Form III, Polymorph Form IV, Polymorph Form V, and Polymorph Form VI, and to processes for the preparation of, compositions containing and to uses of, such polymorph forms.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: January 15, 2019
    Assignee: RaQualia Pharma Inc.
    Inventors: Toyoharu Numata, Hideyuki Aoyama, Kaori Muraji
  • Patent number: 10179780
    Abstract: There are provided: 4-methyl-2-[4-(2-methylpropoxy)-3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-1,3-thiazole-5-carboxylic acid, a sodium salt thereof and crystals of these, useful as a therapeutic agent and a prophylactic agent for gout, hyperuricemia and the like, and a method for producing the same.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: January 15, 2019
    Assignee: Teijin Pharma Limited
    Inventors: Asahi Kawana, Hisae Nozato, Chikashi Kanazawa
  • Patent number: 10179781
    Abstract: Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I: In particular, provided herein are processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions comprising, and therapeutic methods comprising administering such compounds. In particular, provided herein are compounds for the treatment of pain.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 15, 2019
    Inventors: Olga Babich, Robert Z. Luo, Yanlin Wang-Fischer, David J. Palling, Srinivasan P. Venkatachalan
  • Patent number: 10179782
    Abstract: The invention is concerned with the compounds of formula I: and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: January 15, 2019
    Assignee: Genentech, Inc.
    Inventors: Anthony Estrada, Elisia Villemure, Vishal Verma, Daniel Shore, Matthew Volgraf, Baihua Hu, Aijun Lu
  • Patent number: 10179783
    Abstract: The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: January 15, 2019
    Assignee: Taketa Pharmaceutical Company Limited
    Inventors: Stephen Hitchcock, Maria Hopkins, Shota Kikuchi, Holger Monenschein, Holly Reichard, Huikai Sun, Todd Macklin