Abstract: The operation of a measuring probe used for measuring at least one property of a process material is monitored or determined while the measuring probe is in use. The measured property can be a pH measurement, or a CO2 or oxygen concentration of the process material. The measuring probe has an electrode with a sensing element. When the sensing element is in contact with the process material, the electrode delivers a measurement signal to the measurement signal circuit, where the electrode voltage is related to the measured property. The signal-processing unit determines a measurement quantity of the measured property using the measurement signal. When a test signal is delivered by the signal source to the test signal circuit during a verification phase, a coupling element ensures galvanic isolation between the measurement signal circuit and the test signal circuit.

Abstract: An EWOD device includes a first and second substrate assemblies, and a spacer that spaces apart the first substrate assembly from the second substrate assembly to define a channel between them. The spacer defines fluid input ports that are in fluid communication with the channel, and the spacer is configured for directing fluid from the fluid input ports into the channel. The spacer has a combed spacer configuration to define the fluid input ports, including alternating teeth that extend into the channel from a base region, and the teeth isolate adjacent fluid input ports from each other. The spacer may contact only a portion of the first and second substrate assemblies to form a spacerless region within the EWOD device, and the spacer includes regions that are in contact with both the first and second substrate assemblies and extend into the channel to define a cell-gap of the channel.

Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of the electric field sources in a manner that sequentially applies electric fields to the drift tube segments with a magnitude of at least one being different than the others to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. Alternatively, the length of at least one of the drift tube segments may be made different from those of the others to produce the same result. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path.

Abstract: A method to predict the catalytic activity of a metal oxide of formula MxOy where x is a number from 1 to 3 and y is a number from 1 to 8 is provided. The metal of the metal oxide has redox coupled oxidation states wherein the redox transformation is between oxidation states selected from the group consisting of a diamagnetic oxidation state (Md+) and a paramagnetic oxidation state (Mp+), a paramagnetic oxidation state (Mp+) and a ferromagnetic oxidation state (Mf+), and a paramagnetic oxidation state (Mp+) and an antiferromagnetic oxidation state (Ma+)where d, p, f and a are independently numbers from 1 to 6 and one of the oxidation states (Md+), (Mp+), (Mf+), and (Ma+) is formed by reduction by the O2?. The magnetic susceptibility of the metal oxide as a sample in an oxygen environment at a specified temperature is correlated with a value of (Md+ or Mp+ or Mf+ or Ma+)/g (O2 rich).

Abstract: A high sensitivity force gauge using a magnetic PDL trap system is provided. In one aspect, a force gauge includes: a PDL trap having a pair of dipole line magnets and a diamagnetic rod levitating above the dipole line magnets; an actuator with an extension bar adjacent to the PDL trap; a first object of interest attached to the diamagnetic rod; and a second object of interest attached to the extension bar, wherein the actuator is configured to move the second object of interest toward or away from the PDL trap via the extension bar. A method for force measurement using the present force gauge is also provided.

Abstract: A downhole system includes a quartz enhanced photoacoustic spectrometer (QEPAS) configured to be positioned within a wellbore formed in a subterranean zone of a hydrocarbon formation, a sampling system coupled to the QEPAS, and a computer system connected to the QEPAS. The sampling system is configured to be positioned in the wellbore and obtain a sample of a wellbore fluid at a downhole location in the subterranean zone. The QEPAS is configured to spectroscopically scan the sample and to determine a plurality of quantities of a corresponding plurality of hydrocarbons in the same. The computer system includes one or more processors to perform operations including receiving the plurality of quantities of the plurality of hydrocarbons in the sample and determining a plurality of ratios, where each ratio is a ratio of one of the plurality of hydrocarbons with another of the plurality of hydrocarbons.

Abstract: A non-destructive method uses ultrasound measurements to determine some mechanical properties of an elastomeric material. The measurements can be made during manufacture of the elastomer for quality control purposes. The measurements can also be made on the elastomeric material in situ as part of a device to assess degradation of the elastomer over time.

Abstract: An inventive approach is disclosed to integrate Digital Image Correlation (DIC) with the Acoustic Emission method that may be used for structural health monitoring and assessment of critical structural components in civil, mechanical, and aerospace industries. The inventive approach relies on passively recording acoustic emission across the specimen being tested and activating the DIC cameras automatically to measure deformation on the specimen's surface. The resulting acousto-optic system can be used to determine damage initiation, progressive damage development, identify critical regions and make lifetime predictions of the tested specimen.

Abstract: Testing apparatus and handles for testing apparatus are disclosed. An example testing apparatus includes: a first housing portion including a first compartment portion and a trigger compartment; a second housing portion including a second compartment portion that is complementary to the first compartment portion, wherein the first compartment portion and the second compartment portion form a yoke compartment when the first housing portion and the second housing portion are attached; a removable seal positioned around a perimeter of at least one of the first compartment portion or the second compartment portion, wherein the removable seal is configured to be compressed between the first housing portion and the second housing portion to seal the yoke compartment; and a trigger cover complementary to the trigger compartment of the first housing portion, wherein the trigger cover and the second housing portion are removably attached to the first housing portion.

Abstract: An inspection device for inspecting storage silos having mobile body with a tray portion for holding internal components for powering and controlling the inspection device, such as a control circuit and power source. Pairs of spaced apart in-line drive wheels are mounted to the tray portion. An external equipment mounting location (space) is provided between the pairs of drive wheels. A universal wiring harness is located within the tray portion and extends to the external mounting location such that at least two non-identical items of inspection equipment can be interchangeably mounted to the mobile body and connected to the wiring harness. A top portion may be secured over the tray portion to enclose the internal components. Optional fenders may be secured over the wheels and external equipment. Preferably, the external equipment can be swapped without having to remove the top portion from the tray portion.

Abstract: Various embodiments of magnetostrictive transducers (MsTs) for detecting defects in a tubular structure comprise one or more AC coils and one or more magnets. The transducer has a pair of coils (or two coil elements), which are spaced 180 degrees apart relative to the circumference of the tubular structure. Each MsT is selectively operable or configurable so that it may generate either torsional or flexural guided waves.

Abstract: A photo acoustic non-destructive measurement apparatus and method for quantitatively measuring texture of a liquid. The apparatus includes a laser generating tool, an acoustic capturing device, and a data processing unit. The laser generating tool directs a laser towards a surface of a liquid contained in a container and creates pressure waves that propagate through the air and produce an acoustic signal. The acoustic capturing device records and forwards the signal to a data processing unit. The data processing unit further comprises a digital signal processing module that processes the received acoustic signal. A statistical processing module further filters the acoustic signal from the data processing unit and generates a quantitative acoustic model for texture attributes such as hardness and fracturability. The quantitative model is correlated with a qualitative texture measurement from a descriptive expert panel. Textures of liquids are quantitatively measured with the quantitative acoustic model.

Abstract: An acoustic inspection apparatus includes an acoustic-intensity calculating unit, a noise calculating unit, a noise removing unit and an inspecting unit. The acoustic-intensity calculating unit calculates an acoustic intensity, in which an acoustic intensity caused by hammering on an inspection target at a hammering position is canceled out, based on audio signals acquired by microphones in a symmetrical arrangement of at least one pair of microphone positions with respect to the hammering position or in a symmetrical arrangement of two hammering positions with respect to a pair of microphone positions. The noise calculating unit calculates a noise component from the calculated acoustic intensity. The noise removing unit removes the noise component from a physical quantity based on at least one of audio signals acquired at the at least one pair of microphone positions. The inspecting unit performs inspection on the hammering position based on the physical quantity.

Abstract: Disclosed are non-continuous sample fractionating and concatenating device and a dual online multidimensional liquid chromatography system having the same. The non-continuous sample fractionating and concatenating device according to an embodiment of the present disclosure includes a sample supply module which supplies a sample to be analyzed, and a sample fractionation module connected to the sample supply module, and which is continuously supplied with the sample, sets a plurality of unit sample supply times obtained by equally dividing a total sample supply time during which the sample is supplied from the sample supply module, sets a plurality of unit fractionation intervals obtained by equally dividing each of the plurality of unit sample supply times, and concatenates and stores the sample supplied during corresponding unit fractionation intervals within each unit sample supply time to acquire a plurality of fractions.

Abstract: An opening sealing structure is provided with a housing, a step portion, a seal cap, an elastic sealing member, and a cap fixture. The housing has a cap mounting portion having a a cylindrical shape. The step portion is provided on the outer peripheral surface of the cap mounting portion and has a side surface facing the base end side of the cap mounting portion. The side surface of the step portion is inclined along the circumferential direction of the cap mounting portion from the tip end side of the cap mounting portion to the base end side and its inclination angle is smaller on the base end side of the cap mounting portion than on the tip end side. The cap fixture has a cap holding portion movably engaged with the seal cap in a circumferential direction of its outer peripheral surface and an elastic portion connected to the cap holding portion. The elastic portion is provided with a protrusion which engages the side surface of the step portion.

Abstract: A chromatograph device capable of correct measurement even if the retention times of target components change. This chromatograph device is provided with: a storage unit for storing measurement parameters for a plurality of target components, measurement conditions including measurement parameter switching times for each of two target components eluted in succession, and formulas for determining the switching times from predetermined retention times for the target components; a measurement data accumulation unit; a preceding-measurement-data determination unit for determining, at the time of sample measurement, whether there is preceding measurement data for the same column type, mobile phase type, and flow velocity; and a measurement execution unit for carrying out measurement on the basis of the measurement conditions if there is no preceding measurement data.

Abstract: Disclosed is a method for monitoring of foulants present on chromatographic resins using fluorescence probe. The method comprises packing a chromatographic column with a fresh chromatographic resin. The resin packed chromatographic column is washed and an initial reading of fluorescence intensity of the chromatographic resin is measured. The column is then subjected for protein purification followed by excitation of the column at a predefined wavelength. The final reading of fluorescence intensity is measured at a predefined wavelength and the foulant deposited on the column is determined by subtracting the initial reading from the final reading of the fluorescence intensity.

Abstract: A composite material for sensing a chemical species in a medium is provided. The composite material includes a polymer having a glass transition temperature, a porosity promoter dispersed in the polymer in an amount such that the chemical species is transportable from the medium into the composite material at a temperature below the glass transition temperature, and a chemical indicator dispersed in the composite material, the chemical indicator providing an optical response varying with a concentration of the chemical species in the composite material.

Abstract: The present invention provides an analytical method for precipitated particles during co-precipitation reaction, comprising: running a co-precipitation reaction in a reaction vessel to form a precipitated product; injecting a tracking metal to the reaction vessel for a given time duration; collecting the precipitated product containing the tracking metal from the reaction vessel in increments of time to obtain multiple product samples; filtering each collected product sample to separate precipitated particles from filtrate; performing elemental analysis for the tracking metal in the precipitated particles of each collected product sample, to obtain the residence time distribution of the precipitated particles in the reaction vessel according to the concentration of the tracking metal in the precipitated particles.

Abstract: A complex for use in detecting nitrite includes the structure of Formula (I)

Abstract: Disclosed herein are p-n metal oxide semiconductor (MOS) heterostructure-based sensors and systems. The sensors and systems described herein can include sensing element that comprises a first region comprising a p-type MOS material (e.g., NiO) and a second region comprising an n-type MOS material (e.g., In2O3). These sensors and systems can exhibit sensitivity and selectivity to NH3 at ppb levels, while discriminating against CO, NO, or a combination thereof at concentrations a thousand-fold higher (ppm) and spread over a considerable range (0-20 ppm). These sensors and systems can be used to detect and/or quantify NH3 in samples, including biological samples (e.g., breath samples) and combustion gases.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for molecular content analysis. One of the methods includes receiving molecular content data that indicates a molecular content of a portion of a batch of sludge; determining, by a machine learning module included in the system using the molecular content data and multiple parameters, a predicted value for a property of the portion of the batch of sludge; and providing the predicted value for the property of the portion of the batch of sludge.

Abstract: An open-cell foam biological indicator for bacteria detection and removal from water or air, and methods of use.

Abstract: A system and method for determining soil properties, such as organic matter (OM), pH, and electrical conductivity (EC) using a mobile soil sample station and a multispectral sensor mounted on a multi-rotors or professional fixed-wing drone. Combined with an optional fixed soil sampling station and mathematical modeling (built with Cloud-based database with iterative learning process) calibration, the system and method improve soil analysis by enabling real time examination, as well as improving affordability and efficiency.

Abstract: The invention concerns a method of marking a hydrocarbon liquid comprising the step of adding to said liquid, as a tracer compound, a compound of Formula I or Formula II: wherein at least one of R1-R6 in Formula I and at least one of R7-R14 in Formula II is selected from: i. a bromine or fluorine atom; ii. a partially or fully halogenated alkyl group; iii. a branched or cyclic C4-C20 alkyl group; iv. an aliphatic substituent linking two positions selected from R1-R6 in Formula I to one another or two positions selected from R7-R14 in Formula II to one another; or v. a phenyl group substituted with a halogen atom, an aliphatic group or halogenated aliphatic group and none of R1-R6 in Formula I and none of R7-R14 in Formula II being a sulphonate group or COOR15, where R15 represents H, C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, C3-C15 cycloalkyl or aryl.

Abstract: The present invention relates to novel tracer substances useful in the analysis for semi-volatile organic contaminants (SVCs) such as PCBs (polychlorinated biphenyls). The invention also describes methods for establishing multilayered sealant barriers towards SVCs, which barriers contain said tracer substances, and methods for assessing the integrity of such barriers.

Abstract: A method and apparatus for analyzing a biologic fluid sample for at least one target analyte is provided. The method includes providing an analysis chamber having at least one optically responsive chemical sensor (ORCS), sample and calibration fluid regions, and at least one fluid separator that separates the sample and calibration fluid regions. A first portion of each sensor is disposed in the sample fluid region and a second portion of each sensor is disposed in the calibration fluid region. The ORCS is configured to optically respond in the presence of the target analyte and when interrogated with one or more predetermined wavelengths of light. The method further includes disposing at least one calibration fluid having target analyte in a known or ascertainable concentration in the calibration fluid region, and disposing the biologic fluid sample in the sample fluid region.

Abstract: A microelectrode or an array of microelectrodes for communicating with one or more adjacent electrically excitable cells. The microelectrode array comprises two or more microelectrodes. Each microelectrode comprises a body with a perimeter; an electrode wire that is electronically connected to the body and that is electronically connectible to an electronic system; and a ridge that extends away from the perimeter of the body for increasing a sealing-resistance value between the electrode and the one or more adjacent electrically excitable cells.

Abstract: The present invention relates to a tunnel recognition technology-based nano-detection device and method. The said detection device consists of nano wand, plane electrode, active power and current tester. The said detection method consists of the following steps: Place the said nano wand into the test solution with a specific DNA or RNA sequence, and place the said plane electrode on the surface of the said test solution; import the said DNA or RNA sequence into the said transmission pipeline; detect and record the current change displayed by the said current tester; read the base signal of the said DNA or RNA sequence based on the said current change detected. The technical scheme of the present invention is based on DNA sequence direct reading techniques, characterized by quick reading and high accuracy.

Abstract: The invention discloses a proteoliposome or a planar lipid bilayer membrane comprising a single protein manufactured using glycerol or polyethylene glycols (PEG) in the rehydration step. Products so prepared are useful for nanopore sensing technology, including ultrafast DNA sequencing and biomedical diagnostic applications.

Abstract: A light-emitting module for use in a system for measuring whole-blood hemoglobin parameters or whole-blood bilirubin parameters. The light-emitting module includes an LED light source capable of emitting light wherein the light is directed thereby defining an optical path and a plurality of optical components.

Abstract: A calibrating-light module for use in a system for measuring whole-blood hemoglobin parameters or whole-blood bilirubin parameters. The calibrating-light module includes a calibrating module housing, a light beam receiving portion connected to a first end of the calibrating module housing, a calibrating light portion connected to a side of the calibrating module housing wherein the side is transverse to the first end, and an optic fiber portion connected to a second end of the calibrating module housing wherein the calibrating module housing, the light beam receiving portion and the optic fiber portion are aligned with an optical path and the calibrating light portion is spaced from and transverse to the optical path.

Abstract: An optical component group for use in a spectrometer module of a system for measuring whole-blood hemoglobin parameters or whole-blood bilirubin parameters. The optical component group includes a light dispersing element and an achromatic lens assembly disposed between the light dispersing element and a light entrance port of the spectrometer module where the achromatic lens assembly is thermo-compensating permitting thermal expansion and contraction of the achromatic lens assembly in a linear direction where the linear directions is also transverse to a light beam from the light entrance port through the achromatic lens assembly and to the light dispersing element and back through the achromatic lens assembly.

Abstract: A health monitoring system includes: a measurement unit that measures fluid information about a fluid in a puddle of water into which urine excreted by a user of a toilet has flowed; an analysis part that analyzes the excreted urine by assaying a fluid model formed by modeling the fluid based on the fluid information; and an estimation part that estimates a disease of the user based on excreted urine information about the excreted urine.

Abstract: Disclosed are a blood coagulation system examination module, a blood coagulation system examination system, and a blood coagulation system examination method, all of which enable to simply and easily measure thrombin potential with a whole blood sample. The blood coagulation system examination module includes a thrombin potential examination unit configured to examine thrombin potential on the basis of an electrical property of blood as measured at a specific frequency and predetermined time intervals in a predetermined period after reversal of an anticoagulation action working on the blood.

Abstract: The present invention is related to the field of bio/chemical sensing, assays and applications. Particularly, the present invention is related to collecting a small amount of a vapor condensate sample (e.g. the exhaled breath condensate (EBC) from a subject of a volume as small as 10 fL (femto-Liter) in a single drop), preventing or significantly reducing an evaporation of the collected vapor condensate sample, analyzing the sample, analyzing the sample by mobile-phone, and performing such collection and analysis by a person without any professionals.

Abstract: The present invention relates to use of PAK4 and CRTC1 for the treatment or diagnosis of a degenerative brain disease. Specifically, the present invention relates to a pharmaceutical composition for the prevention or treatment of a degenerative brain disease comprising PAK4 (p21-activated kinase 4) or a PAK4 activator as an effective ingredient.

Abstract: Provided herein are compositions, therapeutic methods, screening methods, computational methods and biomarkers based upon the elucidation of the interaction among cereblon, its substrates and certain compounds or agents, including small molecules, peptides, and proteins.

Abstract: The present invention relates to a micro-fluid chip for blood vessel formation. The micro-fluid chip of the present invention is constituted by first to fifth channels arranged adjacent to one another on a substrate in sequence, and two or more micro-structures or micro-posts having a gap therebetween are disposed on the interface that each channel forms together with an adjacent channel while contacting the same. Each channel performs a fluidic interaction with a different channel through the gap formed by the micro-structures, and biochemical materials can move therethrough. The micro-fluid chip, according to the present invention, provides a micro-blood vessel having a flat and continuous blood vessel interface outside a body. Furthermore, cancer angiogenesis, cancer intravasation, and cancer extravasation can be modeled using the micro-fluid chip of the present invention. In addition, the micro-fluid chip of the present invention can be used to screen candidate anti-cancer drugs.

Abstract: Microfluidic “organ-on-a-chip” devices have been developed with the aim to replicate human tissues in vitro. However, there is no option to quantitatively monitor biological processes that take place within the chip, over time. Destructive methods in order to analyze, tissue formation, gene expression, protein secretion etc. require the harvest of the “tissue” at a certain time point. Described herein are methods and compositions for non-destructive molecular imaging methods and systems in order to quantitatively monitor specific biological processes, over time, within the chip, without the need to harvest.

Abstract: The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.

Abstract: The invention relates to a method of in vitro culturing or expanding human or animal tissue (2, 2?). The method comprises: obtaining a sample of human or animal tissue; downsizing tissue (21, 21?) of the sample; generating an assembly by placing the downsized tissue on a scaffold or hydrogel (22, 22?); arranging the assembly inside a culture chamber of a 3D perfusion system (23, 23?); and perfusing the assembly in the 3D perfusion system for a predefined time (24, 24?). The method according to the invention allows for preparing and directly culturing in vitro fresh tissue specimens for a high efficient in vitro culturing using a perfused bioreactor system.

Abstract: Disclosed is a discrimination method of tumor cells, which can distinguish between tumor cells and normal cells. By administering in vivo a fluorescent dye such as 5-aminolevurinic acid (ALA) and light scattering particles such as titanium oxide particles separately and by irradiating light, there can be obtained fluorescence of such an intensity that makes it possible to distinguish between the tumor cells and the normal cells more definitely than fluorescence obtained with the fluorescent dye alone. Furthermore, the fluorescence emission time is extended by administering in vivo the fluorescent dye and the light scattering particles separately.

Abstract: A method for detecting a presence and/or a concentration of a target substance in a reagent solution using enzyme-linked immunosorbent assay (ELISA) includes binding the target substance directly or indirectly to an electrode, and binding a detection agent directly or indirectly to the bound target substance. The method further includes modulating a pH of only a portion of the reagent solution in which the bound target substance and the bound detection agent are located using the electrode, the modulated pH of the portion of the reagent solution causing the bound detection agent to undergo a change, and detecting the change in the bound detection agent. The detected change corresponds to the presence of the target substance in the reagent solution and/or the concentration of the target substance in the reagent solution.

Abstract: The invention provides a tandemly repeated protein comprising at least two repeats of an amino acid sequence of an antibody binding protein or a fragment thereof and a cell having the repeats expressed on the membrane thereof, which can be used in immunoassay to improve detection sensitivity and detection limit.

Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.

Abstract: A sample analysis substrate includes a substrate; a first holding chamber; a reaction chamber; a first flow path having a first opening and a second opening respectively connected with the first holding chamber and reaction chamber; a main chamber; a second flow path having a third opening and a fourth opening respectively connected with the reaction chamber and the main chamber; and a magnet accommodation chamber capable of accommodating a magnet. The first opening is located closer to a rotation shaft than the second opening. The second opening is located closer to the rotation shaft than the third opening. The magnet accommodation chamber is located at a position at which, in the case where the magnet is accommodated in the magnet accommodation chamber, the magnet captures magnetic particles in the main chamber. The sample analysis substrate is rotatable to transfer a liquid.

Abstract: A toner composite material includes toner particles that include a sulfonated polyester and a wax and metal nanoparticles disposed on the surface of the toner particles. A method includes providing such toner composite materials, fusing the material to a substrate and covalently linking a ligand to the surface of the silver nanoparticles via a thiol, carboxylate, or amine functional group. Detection strips include a substrate and such toner composite materials fused on the substrate.

Abstract: Herein is reported a method for determining the binding affinity of the binding sites of a bivalent full length antibody of the human IgG1 subclass to a homo-multimeric antigen comprising the steps of i) incubating a mixture comprising the antibody and a polypeptide that is derived from lysine-gingipain of porphyromonas gingivalis at a pH of from pH 7.5 to pH 8.5, in the presence of a reducing agent, at a temperature of from 30° C. to 42° C., for time of from 10 min. to 240 min. to cleave the antibody into Fabs and Fc-region, and ii) determining the binding affinity of the Fabs of the antibody for its antigen using a surface plasmon resonance method by directly applying the incubated reaction mixture obtained in the previous step in the surface plasmon resonance method and therewith determining the binding affinity of the binding sites of the bivalent full length antibody of the human IgG1 subclass.

Abstract: Nanotube based lateral flow test device described herein is a lateral flow based diagnostic device, which uses arrays of fragments of single wall carbon nanotubes as sensor to detect the biomarkers at ultralow concentration (below picogram per milliliter). The device is consisted of the following components: (1) a lateral flow strip which typically is consisted of a backing film laminated with conjugate/sample pads, nitrocellulose membrane, wicking pad, (2) the arrays of single wall carbon nanotube conjugate with antibody which is immobilized on the membrane of the lateral flow device as the test line, (3) pairs of micro-electrode are installed on top part of the cassette, (4) a cassette which holds the lateral flow strip. The device can be used in clinical environments for biomarker detection.