Abstract: An adjustable height tool for locating a magnetically readable and settable valve which includes a wall having a first perimeter. A platform can be disposed within the first perimeter. A valve cut-out can disposed within the platform and receive at least a portion of the valve. A movable foot can be disposed below the platform by which a displacement element moves the foot at least one of toward or away from the platform, in fixed increments of about 1.5 mm, upon rotation of the displacement element. This movement increases or decreases the distance between the platform and the skin/valve.

Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.

Abstract: A single-piece, injection molded, hand-held liquid dispensing applicator. The single-piece applicator comprising a source of fluid and a frangible applicator tip attached to the fluid source. When the frangible applicator tip is broken, the fluid flows from the source to an absorbent member attached to the applicator tip to spread the liquid on a surface. The frangible tip may comprise a support element permanently connected to the fluid source, a relatively rigid tongue element, and a frangible region therebetween. The tongue element may comprise ribs for reinforcement. The frangible tip may comprise a semi-permeable or non-permeable cover to control the speed and direction of the dispersion of the fluid. The dispensing applicator may be used in various medical applications.

Abstract: A device and method for delivering a high viscosity composition is described. The composition includes a bioactive agent for delivery to a subject in need thereof. The method delivers the bioactive agent at a high bioavailability and with little loss of agent to the natural defense mechanisms of the body. The device includes one or more microneedles with structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes.

Abstract: An assembly for mounting medical connector caps includes a carrier formed from a sheet of material and having an array of holes. The assembly also includes a plurality of medical connector caps. Each cap is inserted into one of the holes of the array. The assembly also includes a plurality of sealing tabs. The tabs may be retained on the carrier by friction fit into the holes of the carrier. The carrier may also include a mounting hole to hang on a pole of an IV line.

Abstract: A connector for fluidly coupling proximal and distal tubular segments of a fluid conduit is provided. In one embodiment, the connector can include a connector body having an outer surface defining a first outer perimeter and an inner surface defining a lumen. The connector can also include a connecting device having an open configuration and a plurality of closed configurations. The connecting device can include first and second members configured to engage each other to secure the fluid conduit to the connector. The connecting device can also include a plurality of closed configurations for securing fluid conduits of different sizes.

Abstract: A second part extending around a first part in a plugged-together state. The second part has snap-in element with an inwardly protruding projection for meshing with a complementary recess on an outer surface of the first part to hold the second part fixed in the axial direction on the first part. Both parts have a central passage opening. One part has an end area expanding towards the outlet opening in a connection area, and the other part is connected to an elastic section, arranged in its interior. The front end of the elastic section is pressed into contact with the expanded end area of the opposite part. The projection of the snap-in element maintains the first and second parts meshed together, so that the elastic section exerts a sealing function due to the pressure on the expanding end area.

Abstract: An aseptic coupling device includes: a main body defining a front face; a membrane coupled to the front face, the membrane including a first portion coupled to the front face and a second portion folded over on the first portion; and a low friction member positioned between the first and second portions of the membrane.

Abstract: System, device and method for providing neuromuscular electrical stimulation (NMES) to muscles of foot. The device includes an electrical signal generator for producing a wave pattern of variable frequency, duration, intensity, ramp time and on-off cycle. The device further includes surface electrodes for being positioned over the foot muscles or around ankles and attached to the signal generator. The device includes a wearable device for positioning a first electrode adjacent a heel of the wearer's foot and a second electrode adjacent an arch of the foot. The signal generator is programmed to stimulate the foot muscles and nerves.

Abstract: An electrical connector, in particular for a medical device that is intended to be secured to the skin of a user, is disclosed. The connector includes a base for solidly connecting to the device and a plug for solidly connecting to an electric conductor. The plug includes a connection means and the base includes a plurality of connection means, each being adapted to engage with the connection means of the plug in order to establish a connection between the base and the plug.

Abstract: The function of a strain relief loop of an implantable medical lead is preserved by inhibiting restriction of the strain relief loop from tissue growth onto the strain relief loop. The restriction may be inhibited by either obstructing tissue growth and/or by utilizing a mechanical advantage to overcome the restriction. The tissue growth may be obstructed be isolating the interior of the strain relief loop such as by enclosing the strain relief loop or including an object within the loop. The mechanical advantage to overcome restriction from tissue growth may be provided in various ways such as utilizing a spring loaded mechanism or a structure such as an elastic mesh, tube, or mold having an inherent bias toward a steady state position.

Abstract: A skull-mountable medical device is disclosed. The device includes a housing containing a light source for providing phototherapy to a patient. A light pipe is attached to the housing. The device is configured to be positioned on a patient's skull with the light pipe extending into the patient's brain, such that light from the light source can irradiate a target position within the patient's brain. Once so positioned, the housing may be affixed to the skull via bone screws. The device is powered and controlled by an implantable pulse generator (IPG) that may be implanted into a patient's tissue remotely from the device and connected to the device by wire leads.

Abstract: A cochlear implant electrode arrangement is described that prevents post-surgical retraction of the electrode array from the cochlea. The arrangement includes an electrode lead that carries cochlear stimulation signals from an implanted signal processor, through an oval shaped posterior tympanotomy opening in the facial recess of a patient, to an electrode array implanted in a cochlea of the patient. A retraction limiter slides over the electrode lead through the posterior tympanotomy with projection arms aligned along the long diameter of the posterior tympanotomy, then is rotated to align the projection arms along the short diameter of the posterior tympanotomy, and secured to the electrode lead so that the projection arms prevent post-surgical retraction of the electrode lead back through the posterior tympanotomy.

Abstract: A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing direct current electricity and methods for manufacturing the same. Electrodes are used to deliver a direct current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

Abstract: In one aspect, wireless gastrointestinal stimulations are described herein. In some embodiments, a system described herein comprises at least one transmitter and at least one stimulation device. The transmitter can include a signal generator operable to generate an electromagnetic signal, a first antenna operable to broadcast the electromagnetic signal, and an energy source. The at least one stimulation device is operable to deliver a pattern of electrical pulses to a gastrointestinal tissue comprising a muscle, and the stimulation device includes a circuit board having a circumference, at least one second antenna wrapped around the circumference of the circuit board, the at least one second antenna being configured to receive the electromagnetic signal and to generate an electrical current from the electromagnetic signal, and at least one electrode operable to deliver the electrical current to the muscle.

Abstract: A hybrid method is provided for modulating upper airway function in a subject. The method includes applying first and second therapy signals to the subject to modulate at least one extrinsic laryngeal muscle and at least one intrinsic laryngeal muscle to synergistically control laryngeal motion and vocal fold movement, respectively.

Abstract: Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.

Abstract: Systems and methods are described, including a system for electrostimulation. The system includes a patch (22), including a plurality of electrodes (24a, 24b), and a mobile device (28). A processor (30) of the mobile device is configured to receive an input from a subject (20) that indicates that the subject is experiencing a headache, and, in response to the input, while the patch is coupled to the subject, wirelessly communicate a control signal that causes the electrodes to stimulate the subject. Other embodiments are also described.

Abstract: A method, device and/or system for generating arbitrary waveforms of a desired shape that can be used for generating a stimulation pulse for medical purposes such as for spinal cord stimulation therapy, including the option of using such arbitrary waveforms for charge balancing purposes.

Abstract: An example system includes a stimulation generator configured to deliver electrical stimulation therapy to tissue of a patient in accordance with a stimulation therapy program. The stimulation therapy program may include a set of stimulation therapy parameters. The system may include at least one sensor configured to detect a signal including an evoked compound muscle action potential (eCMAP) in response to the application of stimulation according to the stimulation therapy program. The system may also include a processor configured to adjust one or more or the stimulation therapy parameters based on the detected signal that includes the eCMAP.

Abstract: Optimizing temporal pulse patterns for stimulation delivery to a subject includes: generating a first generation pulse pattern; delivering stimulation according to the first generation pattern to a subject; measuring efficacy, efficiency and side-effect parameters affected by the delivered stimulation; determining a fitness of the first generation pattern using the measured parameters; generating a second generation pattern using the first generation pattern according to the determined fitness of the first generation temporal pattern; and delivering stimulation according to the second generation pattern. Iterative further optimization may include crossing any particular generation temporal pulse pattern with at least one other temporal pulse pattern to generate offspring patterns for further use and optimization. Immigrant random patterns may be added, and offspring patterns may receive point mutations.

Abstract: The present disclosure pertains to cardiac pacing methods and systems, and, more particularly, to cardiac resynchronization therapy (CRT). In particular, the present disclosure pertains to determining whether a patient is experiencing atrial fibrillation (AF). If the patient is experiencing AF, the efficacy of CRT is determined. A signal is sensed in response to a ventricular pacing stimulus. Through signal processing, a number of features are parsed from the signal and a determination is made as to whether the ventricular pacing stimulus evoked a response from the ventricle.

Abstract: An external control device for use with a medical component implanted within a patient. The device comprises a user interface configured for receiving user input, displaying a first graphical representation of the medical component in the context of a global graphical representation of an anatomical region of the patient, displaying a view finder defining a portion of the global graphical representation, and displaying a second graphical representation of the medical component in the context of a local graphical representation of the portion of the anatomical region portion. The external control device further comprises control circuitry configured for, in response to the input from the user, modifying the displayed view finder to spatially define a different portion of the global graphical representation, such that the second graphical representation of the medical component is displayed in the context of a local graphical representation of the different portion of the anatomical region.

Abstract: A neurostimulation system configured for providing neurostimulation therapy to a patient. A user customizes a pulse pattern on a pulse-by-pulse basis. Electrical stimulation energy is delivered to at least one electrode in accordance with the customized pulse pattern.

Abstract: Devices, systems, and methods are disclosed for relaying information from a cardiac pacemaker to an external device. Logic on the pacemaker modulates a heartbeat clock of the pacemaker to encode information onto a blood pressure sequence by adding or subtracting a small subinterval to or from a pulse repetition interval of the pacemaker. A muscle stimulator beats the heart according to the modulated sequence. A monitoring device external to the body monitors the blood pressure to retrieve the encoded information, or message. The encoded information is then decoded to determine the information in the message. This information may concern the pacemaker as well as other devices within the body that communicate with the pacemaker such as blood monitors, etc. Since the message is conveyed via simple modulation of the heart beat intervals, no separate transmitter is required in the pacemaker which would otherwise increase cost and decrease battery life.

Abstract: Methods and devices for testing and configuring implantable medical device systems. A first medical device and a second medical device communicate with one another using test signals configured to provide data related to the quality of the communication signal to facilitate optimization of the communication approach. Some methods may be performed during surgery to implant one of the medical devices to ensure adequate communication availability.

Abstract: A method of manufacturing a feedthrough having an enhanced hermetic sealing and used for a human implantable medical device such as a deep brain stimulator, a implantable AED, a implantable spinal cord stimulator and so on. Thus, more enhanced reproducibility and productivity in the diffusion welding and the laser hole machining may be guaranteed in the present method of manufacturing the feedthrough, compared to the conventional method using the ceramic metallizing and the brazing.

Abstract: A method for operating a defibrillator including an aural output device includes causing the output device to deliver a first verbal instruction which includes a prompt to call an emergency response system; determining if the user elects to have the defibrillator continue on to a second instruction; and if it is determined that the user elects to have the defibrillator continue on to the next instruction, causing the defibrillator to deliver the second verbal instruction. In an exemplary embodiment, the step of determining if the user elects to continue on to the second instruction includes the step of determining if the user has performed an action upon the defibrillator.

Abstract: An external defibrillator system is disclosed that generates and applies a diagnostic signal to the patient in conjunction with defibrillation therapy. The diagnostic signal is designed to elicit a physiologic response from the patient's heart, namely, mechanical cardiac response and electrical cardiac response, electrical cardiac response only, or no cardiac response. Depending upon the type of cardiac response detected, the system selects an appropriate resuscitation protocol that considers the likely responsiveness of the patient to defibrillation therapy. In one practical embodiment, a stimulus signal is applied to patients that show mechanical and electrical capture in response to the diagnostic signal. The stimulus signal maintains the mechanical capture (and, therefore, perfusion) for a period of time prior to the delivery of a defibrillation pulse.

Abstract: A device uses cold plasma to treat cancerous tumors. The device has a gas supply tube with a delivery end. The gas supply tube is configured to carry a gas to the delivery end. A syringe is provided having an opening. The syringe is connected to the supply tube and configured to carry the gas to the opening. A first electrode is positioned inside said syringe, and a second electrode is positioned adjacent to the opening. The first and second electrodes excite the gas to enter a cold plasma state prior to being discharged from the opening of the syringe. An endoscopic tube can be used instead of the syringe. An exhaust tube can be provided to remove gas introduced into the body cavity by the cold plasma jet.

Abstract: One aspect of the present disclosure relates a system that can employ micromagnetic stimulation to activate or suppress one or more areas of the central nervous system. A portion of the central nervous system can be exposed. A probe can be configured to be located in proximity to the exposed portion of the nervous system. A microcoil (of a size less than or equal to 10 millimeters) can be coupled to the probe and configured to activate or suppress the portion of the central nervous system via electromagnetic induction.

Abstract: A light therapy device is provided that emits both blue spectrum wavelength light and cyan spectrum wavelength light stimulate intrinsically photosensitive Retinal Ganglion Cell (ipRGC) receptors located in a human eye. The light therapy device may be attached or secured in an area of or directly to a consumer device, such as a computer, or laptop, etc., so that a user operating the consumer device may utilize the consumer device and the light therapy device at the same time. Further, settings of the light therapy device may be controlled utilizing an application that may be executing on a computing device.

Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.

Abstract: Disclosed is a therapeutic lamp platform combination light therapy mask. According to an exemplary embodiment of this disclosure, provided is a phototherapy device comprising a therapeutic lamp platform including a mask including a plurality of radiant lamps having a mixed combination of different wavelength radiant energy and disposed to communicate the radiant energy to a user treatment area, the plurality of radiant lamps further disposed to provide radiant therapy to provide a first treatment session including a first set of wavelength radiant energy, and a second treatment session including a second set of wavelength radiant energy including at least one wavelength radiant energy not provided in the first treatment session; and a frame for supporting the mask on a user.

Abstract: A method and apparatus for determining the circadian input of a light source includes selecting a circadian input to be measured based on an action spectrum corresponding to a wavelength sensitivity of photoreceptors for a circadian regulation system, where the circadian input is configured to stimulate a retinaldehyde photopigment, and for measuring spectral intensity across the action spectrum to determine the circadian input of the light source.

Abstract: A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view (BEV) of the radiation delivery device, where each BEV has corresponding area elements resulting from beam collimation. BEV region connectivity manifolds are constructed from the patient model, the dosimetric constraints, the delivery coordinate space, and existing beam trajectories, wherein each of the BEV region connectivity manifolds represents connections between contiguous 2D target regions, where each of the 2D target regions is defined at each of the vertices of the delivery coordinate space.

Abstract: A system for radiation therapy include an imaging device (108) configured to scan an area of interest for tissue undergoing radiation therapy to collect one or more images of the tissue. An interpretation module (110) is configured to receive the one or more images of the tissue to determine a burn status of the tissue and provide adjustments for a radiation treatment plan in accordance with the burn status.

Abstract: Disclosed is a computer-implemented medical data processing method for supporting positioning a patient for treatment by at least one of radiotherapy or radiosurgery, the method comprising executing, on at least one processor of at least one computer, steps of: a) acquiring (S11), at the at least one processor, planning image data describing a digital planning image of an anatomical body part of a body (1) of the patient; b) acquiring (S12), at the at least one processor, planning image alignment data describing a relative position between the anatomical body part and a predetermined reference position at the point in time when the planning image data was generated; c) acquiring (S13), at the at least one processor, thermal reference image data describing a thermal reference image of the anatomical body part; d) acquiring (S14), at the at least one processor, thermal imaging device reference position data describing a relative position between a thermal imaging device (17) used for taking the thermal referenc

Abstract: The invention comprises a method and apparatus for tracking and/or imaging impact of a particle beam treating a tumor using one or more imaging systems positionable about the tumor, such as a positron emission tracking and/or imaging system, where resulting tracking/imaging data: dynamically determines a treatment beam position, tracks a history of treatment beam positions, guides the treatment beam, and/or images a tumor before, during, and/or after treatment with the charged particle beam.

Abstract: In one embodiment of the invention, a method for irradiating a target is disclosed. A proton beam is generated using a cyclotron. A first information is provided to an energy selection system. An energy level for the protons is selected using an energy selection system based on the first information. The first information comprises a depth of said target. The proton beam is routed from the cyclotron through a beam transfer line to a scanning system. A second information is provided to the scanning system. The second information comprises a pair of transversal coordinates. The proton beam is guided to a location on the target determined by the second information using a magnet structure. The target is irradiated with the protons.

Abstract: The invention relates to a method and apparatus for control of a charged particle cancer therapy system. A treatment delivery control system is used to directly control multiple subsystems of the cancer therapy system without direct communication between selected subsystems, which enhances safety, simplifies quality assurance and quality control, and facilitates programming. For example, the treatment delivery control system directly controls one or more of: an imaging system, a positioning system, an injection system, a radio-frequency quadrupole system, a ring accelerator or synchrotron, an extraction system, a beam line, an irradiation nozzle, a gantry, a display system, a targeting system, and a verification system. Generally, the control system integrates subsystems and/or integrates output of one or more of the above described cancer therapy system elements with inputs of one or more of the above described cancer therapy system elements.

Abstract: The present invention is directed to oral compositions comprising an orally-acceptable carrier and a silica abrasive comprising a precipitated amorphous silica compound having an average particle size of from 5 ?m to 20 ?m, oil absorption of from 60 cc/100 g to 120 cc/100 g, and an Einlehner hardness of from 4 to 11, and methods of use thereof.

Abstract: A user-controllable braking system, including a descent tether connectable to a support and configurable for descending a user; a rigid body configured to be connectable between the descent tether and a user for enabling control of the descent by the user; a pulley rotatably positioned on the rigid body, the descent tether positionable around the pulley; a brake member yieldably positioned on the rigid body adjacent the pulley; a bias member operatively associated with the brake member to bias the brake member away from the pulley; and a lever pivotally connected to the rigid body and operable to bear against the brake member to controllably overcome the bias member and controllably bear the brake member against a portion of the descent tether. Operation of the lever by the user enables the user to controllably bear the brake member against the portion of the descent tether positioned around the pulley to provide a braking force.

Abstract: Systems, methods, and devices for an end of service life indicator for a respirator are described herein. For example, a device can include a cartridge containing a filter material and an insert extending through at least a portion of the filter material having a first path with a first opening to provide a sample of air that is representative of a saturation of the filter material and a second path with a second opening configured to provide a filtered sample of the air throughout a service life of the cartridge.

Abstract: The invention relates to a method for the control of the breathing gas supply, in particular of the oxygen supply, from a pressure-leading supply conduit (1) to one or more breathing masks (3) of an oxygen emergency supply device in an air vehicle, in particular in an aircraft, with which an on/off valve (2) is arranged between the supply conduit (1) and the one or the several breathing masks (3), with which valve the conduit connection can be blocked or released, with which a desired mass flow dependent on cabin pressure is set and the actual mass flow is detected, wherein in a first method step the valve (2) is activated in an opening manner until the error between the actual mass flow and the desired mass flow and which is summed over time exceeds a previously fixed maximal error value (4), whereupon the valve (2) in a second method step is activated in a closing manner until the error between the actual mass flow and the desired mass flow and which is summed over time exceeds of a previously fixed minimal

Abstract: A lineman safety harness adapter system for use in association with a harness, having: a first harness adapter having a first strap having a first top end and a first bottom end loop configured to receive a first locking element at a first bottom end, a second strap having a second top end and a second bottom end loop configured to receive a second locking element at a second bottom end, a third strap having a third top end and a third bottom end loop configured to receive a third locking element at a third bottom end; the first strap, the second strap, and the third strap meeting at the first top end, the second top end, and the third top end into a first top loop configured to receive a fourth locking element.

Abstract: The safety anchor includes a base, which is fixable to a roof structure; an absorber, which is attached to the base; and a housing, which houses the absorber. A clamping member is provided within the housing for clamping the housing against the base.

Abstract: An approach is that uses a first amount of energy used by a motor to open a vent and reducing the amount of energy to a second amount of energy to maintain the vent in an open position.

Abstract: A fire resistant system comprising a flexible blanket sized to be deployable on or over an edifice, or part thereof, the blanket being flame retardant and heat resistant, the blanket consisting of aromatic polyamide (aramid) fibers defining a knit yarn fabric, the blanket fabric defining distributed vent openings of small size to freely pass air from one side of the blanket to the other, and away from elongated edifice associated objects such as hot embers, the blanket having edges configured to be pulled for distributing the blanket over the edifice.

Abstract: A method of operating safety mechanism includes extending a safety pin to block a poppet from opening a flow path from a pressure vessel in the event of the pressure vessel being unmounted from a bracket or in the event of the bracket being unmounted from a support structure. The method includes retracting the safety pin to allow free movement of the poppet for opening the flow path only in the event of the pressure vessel being mounted to the bracket and the bracket being mounted to a support structure.