Abstract: A combustible gas sensor includes a first sensing element, which includes a catalyst and a heating element in operative connection with the catalyst to heat the catalyst above a temperature to combust gas analytes of interest, and electronic circuitry in operative connection with the heating element of the first sensing element to periodically cycle the first sensing element between a temperature above the temperature to combust the analytes of interest and a temperature at which the catalyst is substantially inactive to catalyze oxidative combustion of the analytes of interest. The electronic circuitry is adapted to determine a species of at least one of the gas analytes of interest from a first output of the combustible gas sensor during an ON time within a cycle duration. The electronic circuitry is further adapted to determine a concentration of the species of gas from a second output of the combustible gas sensor.

Abstract: According to one embodiment, an electronic device comprises a circuit board, an electrical component, and a measurement unit. The circuit board has a first face. The electrical component includes a second face electrically connected to the first face via a bonding material, a first end in a first direction along the second face, and a second end. The second end is opposite to the first end in the first direction. The measurement unit is configured to measure a characteristic changing depending on a conductivity of the bonding material. A first distance between the first face and the first end is shorter than a second distance between the first face and the second end. The measurement unit includes a first measurement unit configured to measure the characteristic of a part of the bonding material. The part is adjacent to the first end.

Abstract: A measurement apparatus to measure a physical quantity related to a measurement target by use of a sensor, comprising: an apparatus enclosure; a control unit to be electrically connected to the sensor; and a moving member including a sensor holding unit to hold the sensor, the moving member being movable to protrude the sensor holding unit outwardly of the apparatus enclosure and further including a conductive member to electrically connect the sensor to the control unit.

Abstract: Provided are site specific chemically modified nanopore devices and methods for manufacturing and using them. Site specific chemically modified nanopore devices can be used for analyte sensing and analysis, for example.

Abstract: The present invention announces a method for extending the storage life of a test reagent for quantification of ionic components in samples by using an anion sensor. The purpose of the present invention is to provide an anion sensor, wherein the storage life of the anion sensor itself may be extended, to thereby extend the storage life of the anion sensor beyond that of conventional anion sensors. According to the present invention, through adjustment of the pH of the internal solution (internal gel liquid), it is possible to provide an anion sensor that maintains consistent performance, and has longer storage life.

Abstract: A method of operating a sensor to detect an analyte in an environment, wherein the sensor includes a working electrode and circuitry in operative connection with the working electrode, includes performing a sensor interrogation cycle including applying electrical energy to the working electrode to generate a non-faradaic current, measuring a response to the generation of the non-faradaic current to determine a state of the sensor, and actively controlling the circuitry to dissipate the non-faradaic current.

Abstract: An O2 sensor includes a sensor element using a solid electrolyte layer and a pair of electrodes placed at a position to interpose the solid electrolyte layer, detects an exhaust gas from an internal combustion engine as an object of a detection, and outputs an electromotive force signal depending on an air-fuel ratio of the exhaust gas. The sensor element is connected with a constant current circuit supplying a constant current that is prescribed. A microcomputer conducts an abnormality diagnosis of an output response of the sensor element on the basis of a state of variation in an electromotive force output. Further, when the microcomputer conducts the abnormality diagnosis, the microcomputer restricts a supply of the constant current by the constant current circuit before conducting the abnormality diagnosis.

Abstract: The presently claimed invention provides an electrochemical analytical apparatus for electrochemical bath analysis. The apparatus comprise a static electrode and a rotatable unit. As steady liquid flow can be generated on the electrolytic surface of the static electrode by the rotatable unit through rotation, the static disk electrode does not involve any movement during the bath analysis such that the design of the electrical contact in the electrode can be substantially simplified.

Abstract: A NOx sensor includes a pump cell, a monitor cell, and a sensor cell, and the pump cell discharges an oxygen in an exhaust gas introduced into a chamber. The sensor cell outputs a detected signal depending on a concentration of a NOx according to a gas after the oxygen is discharged. A microcomputer of a sensor control circuit temporarily changes an amount of the oxygen discharged by the pump cell, and then calculates output change amounts ?Ip, ?Is, and ?Im of the cells. The microcomputer performs a correction of the concentration of the NOx detected by the sensor cell and a deterioration diagnosis of the sensor cell, based on the output change amounts ?Ip, ?Is, and ?Im of the cells. When the sensor cell current Is is smaller than the monitor cell current Im, the microcomputer determines that the NOx sensor has an abnormality.

Abstract: The present application is directed to the use of electrophoresis with UV detection in the determination of iodine nutritional status in human biological specimens, specifically for monitoring iodine deficiency/inadequacy in large-scale epidemiological studies. In particular, the present application is directed to a method for determining iodide and iodide uptake inhibitors in a human biological sample when using sample self-stacking with capillary electrophoresis and UV detection.

Abstract: Methods of characterizing ion-exchanged chemically strengthened glass containing lithium are disclosed. The methods allow for performing quality control of the stress profile in chemically strengthened Li-containing glasses having a surface stress spike produced in a potassium-containing salt, especially in a salt having both potassium and sodium. The method allows the measurement of the surface compression and the depth of the spike, and its contribution to the center tension, as well as the compression at the bottom of the spike, and the total center tension and calculation of the stress at the knee where the spike and the deep region of the stress profile intersect. The measurements are for a commercially important profile that is near-parabolic in shape in most of the interior of the substrate apart from the spike.

Abstract: A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet and an ion outlet, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the single pass drift tube between the ion inlet and the ion outlet thereof, and at least one ion steering channel controllable to selectively pass ions traveling through the single-pass drift tube into the multiple-pass drift tube via the ion inlet of the multiple-pass drift tube and to selectively pass ions traveling through the multiple-pass drift tube into the single-pass drift tube via the ion outlet of the multiple-pass drift tube. The single-pass drift tube separates in time ions traveling therethrough according to a first function of ion mobility, and the multiple-pass drift tube separates in time ions traveling one or more times therethrough according to the first or a second function of ion mobility.

Abstract: A magnetic particle inspection tool is provided including a yoke with an inspection magnet, a first magnetic member, and a second magnetic member. The inspection magnet is configured to magnetize a work piece. The first magnetic member is rotatable relative to the inspection magnet between a first position and a second position, and the inspection magnet is slidable relative to the first magnetic member. The first magnetic member and second magnetic member include a plurality of magnetic sources forming a magnetic surface with a first magnetic pattern and a magnetic surface with a second magnetic pattern. The magnetic surfaces are magnetically attracted when the first magnetic member is in the first position and repelled when in the second position.

Abstract: Sensitivity of thin film bulk acoustic resonance (TFBAR) sensors is enhanced by mass amplification and operating a high frequency.

Abstract: A system for non-destructively inspecting brazed joints that includes at least one matrix phased array probe that further includes plurality of ultrasonic transducer elements arranged in an array at one end of the probe, wherein the transducer elements are operative to both generate ultrasonic signals and to receive reflections thereof; and at least one tip adapted to be removably mounted over the array of ultrasonic transducer elements, wherein a region of the at least one tip has been shaped to correspond to the geometric characteristics of an item or a specific portion of an item that includes a brazed joint to be inspected; and a processor running software that includes at least one imaging algorithm for processing data received from the at least one matrix phased array probe and generating color coded ultrasonic C-scan images of inspected brazed joints.

Abstract: A deformation detecting device comprises a vibration module configured to vibrate a first point of a measuring plane of a measured object in a non-contact manner; a transmission time measurement module configured to measure transmission time of vibration from the first point to a second point of the measuring plane in a non-contact manner; an inclination measurement module configured to measure an inclination of the measuring plane to a reference surface in a non-contact manner; and a determination module configured to determine presence/absence of deformation in the measured object by comparing the transmission time with reference transmission time serving as transmission time of vibration from the first point to the second point in a case in which there is no inclination of the measuring plane and corrects the reference transmission time in response to the inclination of the measuring plane.

Abstract: Optically trapped specimens (typically nanoparticles having diameters between 1 and 50 nm) are excited with an optical beam so as to induce vibrations in the specimens. A trapping optical beam and the excitation optical beam can produce vibrations based on a difference frequency based on the trapping optical beam and the excitation optical beam. Scattered optical radiation as a function of modulation frequency can be recorded and used to identify or characterize the specimen.

Abstract: According to embodiments, a sensor includes a structure body, a container, a liquid and a sensing unit. The structure body includes a supporter, and a film unit. The film unit includes a first region. The first region includes a first end portion supported by the supporter, and a first portion being displaceable. The film unit includes an opening. The container is connected to the structure body. A first space is defined between the film unit and the container. The liquid is provided inside the first space. The sensing unit senses a displacement of the first portion accompanying a displacement of the liquid.

Abstract: According to an embodiment, a detection system includes a detection device, an acoustic emission sensor, and a processing unit. The detection device detects a change that occurs in a structure or a change in an environment related to the structure. The acoustic emission sensor detects an acoustic emission wave produced from the structure. The processing unit performs first signal processing to process an acoustic emission signal indicating the acoustic emission wave, which is input from the acoustic emission sensor until a first period of time elapses after a detection signal is input from the detection device. The detection signal indicates that a change has occurred in the structure or the environment related to the structure.

Abstract: A transducer unit includes a substrate, a capacitive transducer provided on the substrate and configured to receive an acoustic wave generated when a subject is irradiated with light from a light source and output an electric signal, a circuit substrate including a current/voltage conversion circuit configured to convert a current output from the capacitive transducer into a voltage, and a flexible printed wiring that electrically connects the capacitive transducer to the current/voltage conversion circuit, in which the circuit substrate is provided on a surface side opposite to a surface where the capacitive transducer is provided among surfaces of the substrate.

Abstract: Disclosed are methods and systems to nondestructively detect cracks at or near a countersink of a fastener, such as a rivet, in a thin walled structure using Lamb waves. Generation and detection of Lamb waves at symmetric locations relative to the fastener provides signals used to calculate a symmetry parameter. The symmetry parameter represents a comparison of the relative amplitudes of the detected Lamb wave signals and provides a simple indication of whether a crack exists.

Abstract: The invention relates to a sampler for providing a sample for high-performance liquid chromatography, in which a volume of liquid to be taken up into a cylinder can be aspirated by means of a first drive and can be compressed to a high pressure level by means of a second drive independent of the first drive or can be decompressed from this level in a controlled manner.

Abstract: A conductivity detector includes a flow channel, an electrode arrangement, and a detector. The flow channel has a tube shape with a channel diameter through which a solution including ion components flows. The electrode arrangement is on the flow channel and includes at least an anode and at least a cathode. The anode and cathode are spaced apart by an electrode gap less than or equal to the channel diameter. The detector is connected to the electrode arrangement to detect electrical conductivity of the ion components.

Abstract: The present disclosure provides a gas chromatography-ion mobility spectrometry apparatus, including a housing, an injection port mounted to and connected with the housing and configured for input of a gas containing a sample therein, a multicapillary column configured for separation of a gas substance and an ion mobility tub configured for analysis of the gas substance. The gas chromatography-ion mobility spectrometry apparatus further includes: a gas path part connected with the ion mobility tube and configured for providing the gas to the ion mobility tube and receiving a gas discharged from the ion mobility tube; and a buffer base part detachably mounted to the housing and configured to isolation vibration outside the buffer base part, the ion mobility tube being disposed on the buffer base part, wherein the gas path part is mounted in an interior space of the buffer base part.

Abstract: A device and associated method can detect hydrocarbon gas with at least a control module having a plurality of different gas detection means housed in a mobile enclosure, the control module configured to activate at least two different gas detection means to provide amounts and types of gases present in a fluid.

Abstract: A device (10) and method are provided for measuring the plant growth conditions within a substrate. A first and a second linear arrays of probes (16, 18) are used, allowing multiple measurements of properties of the substrate. Using multiple measurements at different levels in the substrate and then combining these multiple measurements, allows plant growth conditions to be accurately derived.

Abstract: A method and system for monitoring the health and growth of plants in a field. The method and system acquire a thermal image indicative of thermal energy emitted by the plants and process the thermal image to assess variations in the temperatures among the plants.

Abstract: A method and system for testing soil includes wetting a selected soil sample to obtain a soil solution and measuring an initial pH of the soil solution. A buffer solution is then applied to the soil solution to displace alkaline anions from soil colloids of the soil solution with a displacement agent and to neutralize the alkaline anions with a neutralization agent in a buffer having a buffer pH of between 4.38 and 4.42. A resultant pH of the soil solution is then measured. A target pH for the soil sample is selected, and using mathematical relationships of the disclosure, an acidic amendment recommendation is obtained as a function of the initial pH, the resultant pH, and the target pH.

Abstract: A water in fuel (WIF) sensor is disclosed, and comprises a main body defining a surface, a pair of electrical contacts, and a third electrical contact assembly. The pair of electrical contacts each have a first end portion that is located along the surface of the main body. A predetermined resistance flows between the electrical contacts when the first end portions of the electrical contacts are submerged in water. The third electrical contact assembly has a first end portion and a second end portion. The first end portion of the third electrical contact assembly is located along the surface of the main body and the second end portion of the third electrical contact assembly is connectable to a ground.

Abstract: The present invention discloses a method for finding a cell nucleus of a target cell from a cell image, wherein the cell image includes the target cell and at least one variation cell, and the target cell includes cytoplasm and the cell nucleus. The method includes steps of: (a) processing the cell image via an image processor such that the cytoplasm, the cell nucleus and the variation cell have different shades of color; (b) demarcating the outlines of the cytoplasm, the cell nucleus and the variation cell; (c) calculating geometrical reference points of the outlines; (d) calculating the distances from the geometrical reference point of the cytoplasm outline to the geometrical reference point of the cell nucleus outline and to the geometrical reference points of the variation cell outlines; and (e) finding a specific geometrical reference point having a shortest distance to locate a specific outline corresponding to the specific geometrical reference point as the cell nucleus.

Abstract: An apparatus for spectroscopic tissue analysis is disclosed. The apparatus comprises: a light delivery system configured to direct an excitation signal on to a tissue sample; a light collection system configured to collect a backscattered signal comprising diffuse reflectance photons backscattered by the tissue sample; an imaging device; a spectrometer; an optical adaptor configured to direct a first portion of the backscattered signal to the imaging device and a second portion of the backscattered signal to the spectrometer; and an analysis system configured to apply polar decomposition to spectral image data of the tissue captured by the imaging device and the spectrometer and thereby derive polarization metrics for the tissue sample.

Abstract: A system and method includes nano opto-mechanical-fluidic resonators (nano-resonators), e.g., for identification of particles, e.g., single viruses and/or cells.

Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.

Abstract: A nanopore based sequencing system is disclosed. The system includes a plurality of nanopore sensors, each nanopore sensor having a top portion for receiving a fluid. The system further includes an inlet delivering the fluid into the nanopore based sequencing system and an outlet delivering the fluid out of the nanopore based sequencing system. The system includes a fluid chamber that comprises one or more fluid flow channels above top portions of the nanopore sensors; wherein the fluid chamber includes at least one divider that limits the width of the one or more fluid flow channels. In some embodiments, the at least one divider limits the width of the one or more fluid flow channel based on whether the surface tension and adhesive forces between the fluid and the fluid flow channel surfaces are sufficient to prevent the fluid from collapsing within the fluid flow channel.

Abstract: The present invention relates to a method for the diagnosis of tumoural conditions and/or of the corresponding state of advance, wherein a specimen of an organic fluid taken from the patient and having a high probability of containing at least one circulating tumor cell (CTC) or a disseminated tumor cell (CTD) is enriched in a population of CTCs or CTDs. According to the invention, at least one type of CTCs or CTDs is isolated by selecting individually single cells in a microfluidic device so to constitute a diagnostic specimen having a purity of at least 90%. On the specimen thus obtained there is subsequently performed a molecular analysis such as to highlight a characteristic thereof suited to enabling diagnosis.

Abstract: Provided herein are methods for diagnosing impaired nutrient absorption or determining a nutrient absorption level in an individual. A first stable absorption isotopologue of a nutrient and a second stable absorption isotopolog of the same nutrient are administered orally and intravenously, respectively, to the individual. Amounts of the first and second isotopologs are both measured in blood samples drawn periodically and a ratio of the first isotopolog to the second isotopolog is calculated providing a level of nutrient absorption. The results are compared with a healthy control or an ideal value of 1.0. The ratio less than that of a healthy control or significantly lower than 1.0 indicates an impaired nutrient absorption in the individual.

Abstract: The present disclosure provides compositions comprising a food product, non-pathogenic microorganism, kits, methods of diagnosing a tumor in a subject, methods of quantifying the number of cancer cells in a cell sample, and methods of detecting a cancer cell, cancer tissue, or cell associated with a hyperproliferative disorder. In some embodiments, the method comprises a step of detecting the presence or absence of a modified substrate or portion thereof in urine of an animal without an instrument and solely by visual inspection of the urine.

Abstract: The present invention is directed to methods and devices for amending undiluted and partially diluted urine samples in a manner suitable for performing immunoassays for target analytes, for example NGAL. Generally, the urine sample is treated with reagents including at least one of buffer materials, water soluble proteins, urease, and other interferent mitigants. These reagents control the pH of the urine sample in a manner suitable for immuno-binding reactions and ameliorate interferences, particularly during the detection step.

Abstract: The disclosure relates to a method and device for detecting and quantifying biological molecules such as cell surface or intracellular ligands/receptors in a dynamic system with high sensitivity and specificity; the method of using such platform optionally in combination with an optical detection system and kits comprising the optical platform.

Abstract: An assay test device, suitable for use as a home pregnancy test kit, comprises a casing and two test panels mounted to an elongate arm. The test panels are held within the casing for storage. Manual operation of a slider causes the test panels to project outwardly from an end of the casing, so that a liquid test sample may be administered to the panels. The panels are then withdrawn into the casing, which has a window allowing the test panels to be observed while the test reaction (typically an ELISA test) takes place. Indicia may be applied to reveal messages when a test panel changes color. The casing and other components comprise a polyolefin treated to be oxo-biodegradable or biodegradable, so that they may rapidly break down in aerobic conditions on disposal.

Abstract: Provided is a method for increasing the specificity of an antibody-based test to help in the diagnosis of autoimmune diseases by contacting a subject's sample with a blocking antigen prior to testing that is capable of binding to any interfering antibody present in the sample. More specifically, a method for increasing specificity of an antibody-based autoimmune disease assay comprising the steps of providing a sample from a subject, contacting the sample with a DFS70 derived antigen, reacting the sample with an autoimmune disease target and detecting antibodies to the autoimmune disease target is disclosed.

Abstract: The present invention discloses a method of determining the presence of autoimmune disease with the use of glycan biomarkers. A method of improving the detection sensitivity of trace glycans from a mixture of glycans and a microfluidic chip therefor are also disclosed.

Abstract: Compositions and methods for diagnosing an increased risk of NPSLE are provided.

Abstract: The present invention provides an easy-to-use and higher-sensitivity immunochromatography device for an RSV, the device using an antibody that binds specifically to F protein of the RSV in a determination region of a chromatography medium, a test kit by an immunochromatography method, and a method for detecting an RSV using these device and kit. The present invention relates to an immunochromatography device in which not only an antibody that binds specifically to F protein of an RSV but also an antibody that binds specifically to N protein of the RSV is solid-phased in a determination region of a chromatography medium. The present invention also relates to a test kit by an immunochromatography method, and a method for detecting an RSV using these device and kit.

Abstract: Described herein is an enzyme detection device for use in the detection of enzyme activity in a test sample. Also provided are indicator molecules for use in the detection of enzyme activity, particularly enzyme cleavage activity, in a test sample, and to methods for detecting the presence of enzyme activity.

Abstract: This document provides methods and materials related to treating renal cell carcinoma. For example, methods and materials for assessing a cancer patient (e.g., a renal cell carcinoma patient) for tumor or peritumoral tissue containing CD14+ cells and proceeding with a cancer treatment option (e.g., a renal cell carcinoma treatment option) based on the presence, absence, or level of CD14+ cells present within the tumor or peritumoral tissue are provided.

Abstract: The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.

Abstract: An object of the present invention is to provide a peptide excellent in resistance against metabolism, having a stable structure in vivo, and capable of penetrating a cell membrane and reaching in cells. The present invention provides a macrocyclic peptide having a macrocyclic structure comprised of four or more amino acids. At least two amino acids not adjacent to each other have a hydrophobic side chain and the hydrophobic side chains interact with each other inside the ring of the macrocyclic peptide in a hydrophilic environment.

Abstract: The present invention relates to simple size exclusion chromatography (SEC) analytical methods useful for the assessment of accurate molecular weight distributions (MWDs) of certain polypeptide mixtures known as glatiramoids. The use of a SEC method based on one or more broad MWD standards furnishes the absolute (not relative) molecular weight distribution profile of complex polypeptide mixtures like, for instance, the glatiramer acetate (GA) polymer.

Abstract: The disclosure relates to assessing heart failure in vitro by measuring the concentration of the marker mimecan in a sample, and optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration of mimecan and the one or more other marker(s) to reference concentrations of this (or these) marker(s) as established in a reference population. The one or more markers may be selected from the group comprising a natriuretic peptide marker, a cardiac troponin marker, and a marker of inflammation. Also disclosed are the use of mimecan as a marker protein in the assessment of heart failure, a marker combination comprising mimecan, and a kit for measuring mimecan.