Patents Issued in March 28, 2019
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Publication number: 20190094205Abstract: The present invention relates to a method, a device, and a kit for detecting a cancer, predicting a cancer risk, determining a cancer stage, determining a cancer prognosis, and/or evaluating the effectiveness of a treatment in a subject by measuring a urinary metabolite in the subject, and a method for testing a cancer.Type: ApplicationFiled: June 9, 2017Publication date: March 28, 2019Applicant: HITACHI, LTD.Inventor: Minoru Sakairi
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Publication number: 20190094206Abstract: A respiratory monitor including a sensor (200) responsive to substance in exhaled breath is mounted in or connected to a respiratory therapy device (100) of the kind that provides an alternating resistance to expiratory flow. The sensor (200) is exposed to biomarkers or other substances in exhaled breath. The vibration in the lungs produced by the therapy device (100) helps release an increased amount of the biomarkers or other substances in the exhaled breath.Type: ApplicationFiled: March 17, 2017Publication date: March 28, 2019Applicant: SMITHS MEDICAL INTERNATIONAL LIMITEDInventors: Michael L. Blomquist, Paul James Leslie Bennett, Anthony Lucio Belisario
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Publication number: 20190094207Abstract: The inventors have found that the interaction between HP1 and INCENP can serve as an indicator for chromosome instability and established a method for evaluating chromosome instability of cancer cells. The evaluation system can be used for screening of anticancer agent with a new-concept of targeting chromosome instability of cancer cells. The inventors further prepared an antibody for specifically recognizing phosphorylation of serine at position 92 of HP1?, by which the action of Aurora B can be evaluated. The interaction between HP1 and INCENP can be readily evaluated by the antibody.Type: ApplicationFiled: February 27, 2017Publication date: March 28, 2019Inventors: Toru Hirota, Yusuke Abe
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Publication number: 20190094208Abstract: A Petri dish bioreactor can allow a standard Petri dish to be converted to a microscopically observable bioreactor. A bioreactor can be formed by the compression of a device against the edge of a Petri dish thus creating a sealed isolated chamber. One advantage of this conversion is to provide an inexpensive device that can be used for cell culture, observation, transportation, and storage in the laboratory and clinical setting. Further, by creating a sealed bioreactor chamber accessible by ports, the device can reduce cross contamination and allow for the maintenance of a controlled microenvironment within the bioreactor.Type: ApplicationFiled: May 4, 2018Publication date: March 28, 2019Inventors: An Vuong, Charlie Chandsawangbhuwana
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Publication number: 20190094209Abstract: A reagent assay having a tubular member having a cross-section. The assay further has a first porous alginate plug shaped having the cross-section within the tubular member and containing a first reagent and a second porous alginate plug shaped having the cross-section adjacent the first porous alginate plug within the tubular member and containing a second reagent.Type: ApplicationFiled: November 15, 2016Publication date: March 28, 2019Inventor: Anna Merritt Holmes
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Publication number: 20190094210Abstract: Various embodiments disclosed relate to a buffered aqueous solution. The buffered aqueous solution includes a buffer. The buffer includes a citrate component having a concentration in the solution in a range of from about 0.1 mM to about 600 mM. The buffer further includes a metal component having a concentration in the solution in a range of from about 0.01 mM to about 100 mM. The buffered aqueous solution has a pH in a range of from about 5 to about 9.Type: ApplicationFiled: September 24, 2018Publication date: March 28, 2019Inventors: John Leon Miamidian, Martin Raymond Gould, Michael Brown
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Publication number: 20190094211Abstract: A chromogenic absorbent material for an animal litter includes an oxidizing agent responsive to peroxidatic/pseudoperoxidatic activity in an animal excretion or a first catalytic compound generating the oxidizing agent in situ. The material also includes a chromogenic indicator being chromogenically responsive to the oxidizing activity of the oxidizing agent, and an absorptive material which is porous, for absorbing the animal excretion. The absorptive material includes a water-absorbing polysaccharide providing absorptive properties to the chromogenic absorbent material; and may also include a second polysaccharide and a superabsorbent polymer. The material may be obtained in the form of particles having a low density and a high porosity, and is usable in conjunction with an animal litter for detecting various diseases in animals.Type: ApplicationFiled: November 28, 2018Publication date: March 28, 2019Inventor: Paul JOLLEZ
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Publication number: 20190094212Abstract: Decoding methods are provided for identifying populations in assays, particularly multiplexing assays and those associated with fluidic devices.Type: ApplicationFiled: October 5, 2016Publication date: March 28, 2019Inventors: John Michael Ramsey, William Hampton Henley, Thomas Linz
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Publication number: 20190094213Abstract: The present invention relates to the use of a control marker for implementing analysis methods on spots, in particular in the context of multiplex analyses. The present invention thus relates to solid supports containing said control marker, their preparation method and their use in analysis methods. The present invention makes it possible to verify the presence, location and/or integrity of the spots at the end of the analysis method, and thus to secure the obtained results while guaranteeing that the yielded result indeed results from a present, intact and localized spot.Type: ApplicationFiled: November 26, 2018Publication date: March 28, 2019Inventors: AGNES ROSELINE CLAUDE POUZET, VINCENT DOURY, LAURENT EMMANUEL FOURNIER, CHRISTOPHE RENE ROGER VEDRINE
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Publication number: 20190094214Abstract: Methods of detecting a target in a sample are provided. Kits for performing the methods described herein are also provided.Type: ApplicationFiled: September 25, 2018Publication date: March 28, 2019Inventors: Boaz Gildor, Dalia Shezifi
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Publication number: 20190094215Abstract: The present invention addresses the problem of making it possible, in a simple immunoassay, to prevent false-positive reactions and reduce measurement value errors so as to accurately detect fFN by suppressing a cross-reaction with plasma FN that is an antigenic component similar to fFN to reduce the detection of plasma FN. When an anti-fFN antibody reacts with fFN in the presence of a specific surfactant according to the present invention, it is possible to accurately detect fFN through the suppression of the cross-reaction between the antibody and FN, even when other FNs such as plasma FN are also present. The specific surfactant is represented by general formula (1): R—O—(CH2CH2O)mH??(1) In the formula, m is 4-30, and R represents an alkyl group.Type: ApplicationFiled: March 30, 2017Publication date: March 28, 2019Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Kanako ITOU, Motoki MORITA, Shouhei YAJI, Shun SAKAI
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Publication number: 20190094216Abstract: Herein is reported an enzyme linked immunosorbent assay for the detection of anti-drug antibodies against a drug antibody in a sample comprising a capture drug antibody and a tracer drug antibody, wherein the capture drug antibody and the tracer drug antibody are employed in a concentration of 0.5 ?g/ml or more, the sample is incubated simultaneously with the capture drug antibody and the tracer drug antibody for 1 to 24 hours, the capture drug antibody and the tracer drug antibody are derivatized via a single lysine residue, the sample comprises 10% serum, and oligomeric human IgG is added to the sample prior to the incubation with the capture drug antibody and the tracer drug antibody.Type: ApplicationFiled: November 21, 2018Publication date: March 28, 2019Applicant: Hoffmann-La Roche Inc.Inventors: Kay-Gunnar Stubenrauch, Rudolf Vogel
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Publication number: 20190094217Abstract: The present invention concerns a device for measuring the concentration of analytes in liquid samples such as bodily samples. The device comprises an application zone, to which a sample can be applied, and which contains a specific molecule capable of specifically binding the analyte of interest, said specific molecule being conjugated to a reporter which can give rise to variations in impedance. The resulting complex migrates by capillarity and enters a detection zone, on which another molecule capable of specifically binding the analyte of interest is immobilised. The concentration of reporter molecules in the detection zone is proportional with the concentration of analyte in the sample, and variations in concentration of reporter molecules yield a measurable change in electrical properties such as a change in impedance and/or capacitance which can be correlated to the concentration of analyte.Type: ApplicationFiled: August 16, 2018Publication date: March 28, 2019Inventors: Jesper Fleischer, Michael Hasenkam, Niels E. Magnusson, Hans Nygaard
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Publication number: 20190094218Abstract: An object of the present invention is to provide an immunochromatography analysis device for detecting gliadin in which a cross-reaction with an antigen in a food other than gliadin is inhibited and which has improved specificity and the invention relates to an immunochromatography analysis device for detecting gliadin including a sample addition part, a labeling substance retaining part, a chromatography medium part having a detection part and an absorption part, wherein the labeling substance retaining part and the detection part contains an antibody recognizing ?-gliadin.Type: ApplicationFiled: February 22, 2017Publication date: March 28, 2019Inventors: Keita SUZUKI, Hiroko MOCHIZUKI, Hisahiko IWAMOTO
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Publication number: 20190094219Abstract: Assays and methods for diagnosing and treating autoimmune diseases. Particularly, the invention provides methods for differential diagnosis of specific autoimmune diseases, including autoimmune rheumatic disorders.Type: ApplicationFiled: September 17, 2018Publication date: March 28, 2019Inventors: Rachel Sorek, Keren Jakobi-Brook, Pennina Safer
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Publication number: 20190094220Abstract: A method for treating infection of group A Streptococcus (GAS) includes grouping a patient infected with GAS into an invasive infected candidate. An antibiotic is then administrated to the invasive infected candidate to treat the infection of GAS. Moreover, the patient is grouped into the invasive infected candidate when a first detected level, determined by ex vivo contacting a first biopsy obtained from the patient with a FSBM recombinant protein having an amino acid sequence set forth as SEQ ID NO: 10, is smaller than 0.6.Type: ApplicationFiled: November 20, 2017Publication date: March 28, 2019Inventors: Chih-Feng Kuo, Ni-Na Tsao, Ching-Chuan Liu, Tzong-Shiann Ho
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Publication number: 20190094221Abstract: Methods, compositions and kits for detecting Group A streptococcus in a biological sample are described. More particularly, the present disclosure provides an immunoassay in which the specificity of detection of Group A streptococcus is enhanced by addition of N-acetyl-D-glucosamine. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of streptococcal infection in a human subject.Type: ApplicationFiled: November 28, 2018Publication date: March 28, 2019Inventors: Peter Yan-Guo REN, Jason MCCLURE, Kevin S. RICHARDSON
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Publication number: 20190094222Abstract: The device for detecting turbidity in an aqueous flushing solution is characterized by a base body, at least one light source, a detector device at which the at least one light source is aimed, a holding unit for a component, containing the flushing solution, between the at least one light source and the detector device, and a display device for the findings of turbidity detected.Type: ApplicationFiled: September 25, 2017Publication date: March 28, 2019Inventors: Franz Ferdinand Becker, Ulrich Paul Hinkel
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Publication number: 20190094223Abstract: Provided are methods of predicting responsiveness of a subject having an inflammatory bowel disease (IBD) to a tumor necrosis factor (TNF)-alpha inhibitor, by analyzing a frequency of at least one subpopulation of immune cells in a tissue biopsy of the subject. Also provided are methods of selecting a treatment for a subject and kits for determining responsiveness of the subject to treatment with a TNF-alpha inhibitor.Type: ApplicationFiled: April 6, 2017Publication date: March 28, 2019Applicants: Technion Research & Development Foundation Limited, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Shai S. SHEN-ORR, Elina STAROVETSKY, Naama MAIMON, Purvesh KHATRI, Renaud GAUJOUX, Francesco VALLANIA
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Publication number: 20190094224Abstract: Provided herein are methods for determining the T cell receptor affinity and sequence of antigen-specific T cells using a micropipette adhesion assay and single cell paired TCR?/TCR? sequencing. Further provided are methods for the treatment of viral infections or cancers by adoptive transfer of high affinity functional T cells.Type: ApplicationFiled: April 6, 2017Publication date: March 28, 2019Inventors: Ning JIANG, Shuqi ZHANG, Keyue MA, Chenfeng HE
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Publication number: 20190094225Abstract: The present application demonstrates that sirtuin 4 (SIRT4) acts as a cellular lipoamidase that negatively regulates pyruvate dehydrogenase complex (PDHC) activity through hydrolysis of its lipoamide cofactors.Type: ApplicationFiled: January 15, 2015Publication date: March 28, 2019Inventors: Thomas Shenk, Todd M. Greco, IIeana M. Cristea, Rommel A. Mathias, Adam Oberstein
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Publication number: 20190094226Abstract: The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number.Type: ApplicationFiled: November 26, 2018Publication date: March 28, 2019Inventors: Darren Roy Link, Michael L. Samuels
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Publication number: 20190094227Abstract: The present disclosure provides synthetic antibodies specific for a disease-associated antigen, and methods of using the antibodies in disease therapy. The present disclosure further provides diagnostic assays involving detecting the presence and/or level in biological sample of an antibody specific for a disease-associated antigen.Type: ApplicationFiled: April 16, 2018Publication date: March 28, 2019Inventors: Lawrence H. Fong, Serena Kwek MacPhee
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Publication number: 20190094228Abstract: A method is provided of diagnosing prostate cancer or the risk of prostate cancer in a patient by detecting antibodies against the following marker proteins or a selection of at least 2 or at least 20% of the marker proteins of any List provided herein in a patient, including the step of detecting antibodies binding the marker proteins in a sample of the patient; and systems and kits for such methods.Type: ApplicationFiled: March 3, 2017Publication date: March 28, 2019Inventors: Johana Andrea LUNA, Klemens VIERLINGER, Christa NOEHAMMER, Regina SOLDO, Magdalena GAMPERL, Lisa MILCHRAM, Andreas WEINHÄUSEL
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Publication number: 20190094229Abstract: Diagnostic and therapeutic applications for endometrial cancer are described. The diagnostic and therapeutic applications are based on certain activation mutations in the FGFR2 gene and its expression products. The present invention is directed to nucleotide sequences, amino acid sequences, probes, and primers related to FGFR2 activation mutants and kits comprising these mutants to diagnosis and classify endometrial cancer in a subject.Type: ApplicationFiled: December 7, 2018Publication date: March 28, 2019Inventors: Pamela Pollock, Paul Goodfellow
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Publication number: 20190094230Abstract: Provided herein are methods and systems for the production of a nanolipoprotein particle (NLP) that includes a scaffold protein a membrane forming lipid and optionally a target protein. At least one of the scaffold protein and target protein can be provided through an IVT system. The membrane forming lipid, scaffold protein and optionally the target protein can be assembled for a time and under conditions that allow obtaining high yield NLPs, NPLs with an increased solubility, an NLP of a controlled size, and/or an NLP having a size predetermined to include a pre-selected target protein.Type: ApplicationFiled: October 12, 2018Publication date: March 28, 2019Inventors: Matthew A. COLEMAN, Paul D. HOEPRICH, JR., Brent W. SEGELKE
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Publication number: 20190094231Abstract: Disclosed are analyte monitoring systems and methods for calibrating an analyte sensor using one or more reference measurements. These systems and methods may include using a conversion function and first sensor data to calculate a first sensor analyte level, weighting a first reference analyte measurement (RM1) and one or more previous reference analyte measurements according to a weighted average cost function, updating the conversion function using the weighted RM1 and the one or more weighted previous reference analyte measurements as calibration points, and using the updated conversion function and second sensor data to calculate a second sensor analyte level. In some aspects, the systems and methods may include updating one or more of lag parameters used to calculate the sensor analyte levels.Type: ApplicationFiled: September 26, 2018Publication date: March 28, 2019Applicant: Senseonics, IncorporatedInventors: Xiaoxiao Chen, Ravi Rastogi, Andrew DeHennis, Patty Sanchez
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Publication number: 20190094232Abstract: Disclosed are analyte monitoring systems and methods for calibrating an analyte sensor using one or more reference measurements. These systems and methods may include using a conversion function and first sensor data to calculate a first sensor analyte level, weighting a first reference analyte measurement (RM1) and one or more previous reference analyte measurements according to a weighted average cost function, updating the conversion function using the weighted RM1 and the one or more weighted previous reference analyte measurements as calibration points, and using the updated conversion function and second sensor data to calculate a second sensor analyte level. In some aspects, the systems and methods may include updating one or more of lag parameters used to calculate the sensor analyte levels.Type: ApplicationFiled: September 26, 2018Publication date: March 28, 2019Applicant: Senseonics, IncorporatedInventors: Xiaoxiao Chen, Ravi Rastogi, Andrew DeHennis, Patty Sanchez
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Publication number: 20190094233Abstract: Disclosed are analyte monitoring systems and methods for calibrating an analyte sensor using one or more reference measurements. These systems and methods may include using a conversion function and first sensor data to calculate a first sensor analyte level, weighting a first reference analyte measurement (RM1) and one or more previous reference analyte measurements according to a weighted average cost function, updating the conversion function using the weighted RM1 and the one or more weighted previous reference analyte measurements as calibration points, and using the updated conversion function and second sensor data to calculate a second sensor analyte level. In some aspects, the systems and methods may include updating one or more of lag parameters used to calculate the sensor analyte levels.Type: ApplicationFiled: September 26, 2018Publication date: March 28, 2019Applicant: Senseonics, IncorporatedInventors: Xiaoxiao Chen, Ravi Rastogi, Andrew DeHennis, Patty Sanchez
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Publication number: 20190094234Abstract: A method of obtaining a class of embryos having a higher implantation potential than from morphology selection alone by selecting from multiple embryos, obtained by fertilizing the plurality of oocytes, a class of embryos having a high implantation potential. The selection is determined from a level of granulocyte-colony stimulating factor (G-CSF) present in the follicular fluid (FF) of each oocyte in the multiple oocytes.Type: ApplicationFiled: November 27, 2018Publication date: March 28, 2019Inventors: Nathalie Ledee, Marie-Pierre Piccinni
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Publication number: 20190094235Abstract: [Problem to be solved] It is to provide a method for selectively and easily quantifying the L-form and/or D-form amino acids to be measured using an AARS with high sensitivity, and an amino acid quantification kit. [Solution to Problem] A method for quantifying amino acids (L-AA and/or D-AA) in a sample using an AARS, wherein the amino acids and the AARS are released from an aminoacyl AMP-AARS complex once formed, and they are used again for forming the aminoacyl AMP-AARS complex, so that reaction products such as pyrophosphoric acid to be measured can be ultimately produced up to a molar number larger than that of the amino acids contained in the sample, and an amino acid quantification kit for performing the method.Type: ApplicationFiled: September 28, 2018Publication date: March 28, 2019Applicants: IKEDA FOOD RESEARCH CO., LTD., HIROSHIMA CITY UNIVERSITYInventors: Daisuke SATO, Tomoko NAKATSUKA, Hideyuki AOKI, Mikiko KIDA, Kenta YAMADA, Shoji KANEKO, Akimitsu KUGIMIYA
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Publication number: 20190094236Abstract: The method for aiding ALS detection provided by the present invention includes determining a profile of signal peptides contained in a bodily fluid from a test subject, and comparing the signal peptide profile thus determined for the test subject with a previously-determined profile of signal peptides in a bodily fluid from a healthy subject. The presence of a difference between the signal peptide profile of the test subject and the signal peptide profile of the healthy subject at a specific molecular weight is then associated with the test subject's suffering from or developing ALS.Type: ApplicationFiled: March 2, 2017Publication date: March 28, 2019Inventors: Nahoko BAILEYKOBAYASHI, Makoto SAWADA, Tetsuhiko YOSHIDA
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Publication number: 20190094237Abstract: A method for detecting a membrane protein using a desorption electrospray ionisation source coupled to a mass spectrometer comprises: desorbing a membrane protein from a surface on which a sample comprising the membrane protein and a solubilising agent is deposited by applying electrospray to the sample; ionising the membrane protein; and detecting the membrane protein using the mass spectrometer. The method may be used for deriving information about a membrane protein, e.g. its structure or conformation or, where a ligand is present, the stoichiometry and dissociation constant of a complex in which the membrane protein is bound to the ligand.Type: ApplicationFiled: February 28, 2017Publication date: March 28, 2019Inventors: Jonathan HOPPER, Carol ROBINSON, Stephen AMBROSE
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Publication number: 20190094238Abstract: Methods for producing isotopically-labelled peptides are provided. Aspects of the method include: contacting a sample including a metabolically tagged protein with a cleavable probe to produce a probe-protein conjugate; separating the probe-protein conjugate from the sample; digesting the probe-protein conjugate to produce a probe-peptide conjugate; and cleaving a cleavable linker to release an isotopically labelled peptide. The method may further include: identifying a predetermined isotopic pattern in a mass spectrum; determining an amino acid sequence of the isotopically labelled peptide; and identifying the site of protein glycosylation based on the determined amino acid sequence. Also provided are cleavable probes for practicing the subject methods, described by the Formula: A-L-(M-Z) where A is an affinity tag, L is a cleavable linker, M is an isotopic label and Z is a chemoselective tag capable of cross-linking a metabolically tagged protein.Type: ApplicationFiled: October 22, 2018Publication date: March 28, 2019Inventors: Carolyn R. Bertozzi, Christina Woo
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Publication number: 20190094239Abstract: An anti-immunoglobulin specific antibody (or fragment thereof), characterised that the antibody or fragment thereof comprises one or more non-disulphide cross-links between at least one heavy chain or fragment thereof and at least one light chain or fragment thereof of the antibody or fragment thereof. A method purifying an anti-immunoglobulin specific antibody (or fragment thereof), characterised that the antibody or fragment thereof comprises one or more non-disulphide cross-links between at least one heavy chain or fragment thereof and at least one light chain or fragment thereof of the antibody or fragment thereof.Type: ApplicationFiled: February 24, 2017Publication date: March 28, 2019Inventors: David L. MURRAY, Stephen HARDING, David R. BARNIDGE, Gregg WALLIS, John MILLS, Jamie ASHBY
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Publication number: 20190094240Abstract: The invention relates to biomarkers and a method of diagnosing or monitoring depression, anxiety disorder or other psychotic disorder.Type: ApplicationFiled: September 6, 2018Publication date: March 28, 2019Inventors: Sabine Bahn, Emanuel Schwarz, Brenda Penninx, Nicole Vogelzangs
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Publication number: 20190094241Abstract: A method for tracking calcium flux of a eukaryotic cell. The method includes growing the eukaryotic cell in the presences of a ytterbium salt in solution and spectroscopically measuring ytterbium in the eukaryotic cell.Type: ApplicationFiled: September 22, 2017Publication date: March 28, 2019Applicant: Government of the United States, as represented by the Secretary of the Air ForceInventors: Jingbo Liu, Sajid Bashir, Jeffrey C. Wigle
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Publication number: 20190094242Abstract: The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.Type: ApplicationFiled: September 6, 2018Publication date: March 28, 2019Inventors: Michael Farrell, Antony Hubbard, Eric May, Lei Tang, Tsu-Shuen Tsao, Wenjun Zhang
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Publication number: 20190094243Abstract: The invention provides a method of diagnosing arthritis or other joint degrading disease in a subject which comprises determining whether there is a presence or increase of lubricin having a joint tissue posttranslational modification, in a blood sample from the subject, the presence or increase of the lubricin having the joint tissue posttranslational modification indicating arthritis or other joint degrading disease in the subject. The invention further provides a kit or protocol for detecting arthritis or other joint degrading disease by detecting lubricin, the lubricin comprising a joint tissue posttranslational modification.Type: ApplicationFiled: February 23, 2017Publication date: March 28, 2019Inventors: Niclas KARLSSON, Chunsheng JIN, Sebastian KALAMAJSKI, Sarah Ann FLOWERS
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Publication number: 20190094244Abstract: The present invention relates to a method for diagnosing the occurrence of a vascular dysfunction or a vascular injury in a subject, said method comprising a step consisting of determining in a plasma sample obtained from said subject the level of free annexin. The present invention further relates to a method for determining whether a subject is at risk for severe vasculopathy, cardiovascular complications and cardiovascular disease, said method comprising a step consisting of determining in a plasma sample obtained from said subject the level of free annexin. Preferably, the methods further comprise the steps consisting of determining the level of circulating phosphatidylserine positive (PS+) microparticles (MPs) in the plasma sample obtained from said subject and calculating the ratio free annexin/circulating PS+MPs.Type: ApplicationFiled: March 22, 2017Publication date: March 28, 2019Inventor: Olivier P. BLANC-BRUDE
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Publication number: 20190094245Abstract: This disclosure relates to the use of anti-?-synuclein antibody to diagnose an elevated level of ?-synuclein in the brain. Specifically, the disclosure relates to the method of assessing the levels of ?-synuclein in a blood plasma or CSF following administration to the test subject of an anti-?-synuclein antibody or antigen-binding fragment thereof, which can bind ?-synuclein with sufficient activity to alter the net efflux of ?-synuclein from brain to blood, or from brain to CSF.Type: ApplicationFiled: May 16, 2018Publication date: March 28, 2019Applicant: Biogen International Neuroscience GmbHInventors: Andreas Weihofen, Thomas Engber, Jan Grimm
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Publication number: 20190094246Abstract: The present invention relates to a biomarker, and/or methods including a non-invasive in vitro method using this biomarker, for diagnosing or monitoring the development or the progression of Alzheimer's disease (AD) or a disease or disorder associated with ?-amyloid peptide (A?) deposition or tau hyperphosphorylation or a disease or disorder characterized by a proteinopathy implicating abnormalities in protein kinase C (PKC).Type: ApplicationFiled: March 7, 2017Publication date: March 28, 2019Inventors: Saliha MOUSSAOUI, Dirk WILDEMANN, Holger WENSCHUH, Karsten SCHNATBAUM, Gilles ULRICH, Jean DE BARRY, Corinne MBEBI-LIEGEOIS, Hueseyin FIRAT
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Publication number: 20190094247Abstract: A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test compound binds to the mutant GPCR when residing in a particular conformation; and d) isolating a test compound that binds to the mutant GPCR when residing in the particular formation. Methods of producing GPCRs with increased stability relative to a parent GPCR are also disclosed.Type: ApplicationFiled: October 4, 2018Publication date: March 28, 2019Applicant: Heptares Therapeutics LimitedInventors: Malcolm Peter Weir, Richard Henderson, Christopher Gordon Tate, Francesca Magnani, Maria Josefa Serrano-Vega, Yoko Shibata, Antony Johannes Warne
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Publication number: 20190094248Abstract: A fluorescent probe for calcium ion detection that has an excellent photofading resistance and quick Ca2+ detection kinetics and can be localized at an arbitrary site in a cell is provided. The fluorescent probe contains a compound represented by the following general formula (I) or a salt thereof: A method for detecting intracellular calcium ions including (a) introducing the compound above or a salt thereof into a cell and (b) measuring the fluorescence emitted by the compound or a salt thereof in the cell is also provided.Type: ApplicationFiled: January 13, 2017Publication date: March 28, 2019Applicant: THE UNIVERSITY OF TOKYOInventors: Kenzo HIROSE, Daisuke ASANUMA, Kohei MATSUI, Rieko TANAKA
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Publication number: 20190094249Abstract: A computer-implemented method of calibrating an in-vitro diagnostic analyzer is disclosed. The method comprises executing a multi-point calibration procedure comprising measuring a plurality of calibrator levels and thereby obtaining a plurality of respective calibration points. The method further comprises calculating a result of the multi-point calibration procedure and determining failure or passing of the multi-point calibration procedure based on the calculated result. In case of failure of the multi-point calibration procedure, the method comprises determining if failure is related to one or more individual failed calibration point(s), and in the affirmative, triggering a repetition of measuring the calibrator level(s) only with respect to the failed calibration point(s) and re-calculating the result of the multi-point calibration procedure after replacing only the failed calibration point(s) with the newly obtained calibration point(s).Type: ApplicationFiled: September 20, 2018Publication date: March 28, 2019Applicant: Roche Diagnostics Operations, Inc.Inventor: Mirko Klingauf
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Publication number: 20190094250Abstract: The present invention provides an automatic analysis device and an automatic specimen processing system having a component-rack supply mechanism that, in a state where a plurality of component racks each having a disposable component mounted thereon are stacked, separates only a component rack at the leading stage of the stack from the other component racks, and supplies the separated component rack to the automatic analysis device or the automatic specimen processing system.Type: ApplicationFiled: January 30, 2017Publication date: March 28, 2019Inventors: Kazuhiro NODA, Tatsuya FUKUGAKI, Takahiro KUMAGAI
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Publication number: 20190094251Abstract: A method of handling a laboratory sample container is presented. In addition, a laboratory apparatus and a laboratory automation system comprising such a laboratory apparatus are also presented.Type: ApplicationFiled: September 14, 2018Publication date: March 28, 2019Applicant: Roche Diagnostics Operations, Inc.Inventor: Michal Malinowski
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Publication number: 20190094252Abstract: A laboratory sample distribution system comprising sample container carriers, a central controller having a network interface, and transport modules is presented. Each transport module comprises a transport surface, wherein the transport surfaces form a transport plane, a controllable driver arranged below the transport surface and configured to move sample container carriers on the transport surface, and a control unit for controlling the driver. The control unit comprises a network interface. The central controller and the control units of the transport modules are connected by their corresponding network interfaces. Each control unit comprises first and second addressing terminals. The addressing terminals are connected sequentially in a daisy chain topology. The first addressing terminal is the first control unit in the sequence and is connected to a first reference potential and the second addressing terminal is the last control unit in the sequence and is connected to a second reference potential.Type: ApplicationFiled: November 27, 2018Publication date: March 28, 2019Applicant: Roche Diagnostics Operations, Inc.Inventors: Patrick Waser, Hans Schneider, Daniel Arnold
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Publication number: 20190094253Abstract: An automatic analysis device is provided with a storage chamber for adjusting the temperature of and storing a container in which liquid is stored, an opening provided in a portion of the storage chamber, and a loader mechanism for bringing the container in and out of the storage chamber by moving the container through the opening, and is characterized in that the loader mechanism and storage chamber are closed by an elastic body. In the present invention, attaching a sealing member for sealing to an upper part from among overlapping parts makes it difficult for debris and dust to adhere to the sealing member and makes it possible to maintain the sealed state of a reagent storage chamber over a long period of time.Type: ApplicationFiled: January 23, 2017Publication date: March 28, 2019Inventors: Yoshiteru HIRAMA, Tatsuya FUKUGAKI
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Publication number: 20190094254Abstract: Embodiments in accordance with the present disclosure are directed to blood transfer apparatuses, sleeve-puncturing assemblies, and methods thereof. An example blood transfer apparatus includes a sleeve-puncturing assembly comprising a sleeve and a hollow conduit. The sleeve is configured and arranged with longitudinal portions to be placed over or engage a blood collection container. The sleeve has an open end that engages with a portion of the blood collection container and another end that provides containment of the blood collection container while the open end is engaged with the portion of the blood collection container. The sleeve further includes a lateral portion to provide support the hollow conduit. The hollow conduit and the longitudinal portions of the sleeve engage with the blood collection container and a blood collection container to provide sufficient pressure while engaged to pull a predetermined amount of plasma or serum from the blood collection container.Type: ApplicationFiled: May 30, 2018Publication date: March 28, 2019Inventor: Thomas J. Musci