Abstract: There is disclosed compositions and methods relating to or derived from anti-CD137 antibodies. More specifically, there is disclosed fully human antibodies that bind CD137, CD137-antibody binding fragments and derivatives of such antibodies, and CD137-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease requiring either stimulation of immune responses or suppression. Diseases amenable to treatment is selected from the group consisting of cancers, autoimmune diseases and viral infections.

Abstract: The present disclosure provides antibodies that specifically bind to human OX40 receptor (OX40) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human OX40 and modulate OX40 activity, e.g., enhance, activate, or induce OX40 activity, or reduce, deactivate, or inhibit OX40 activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g., enhances, activates, or induces OX40 activity. Also provided are methods for treating autoimmune or inflammatory diseases or disorders, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g., reduces, deactivates, or inhibits OX40 activity.

Abstract: Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell. The transformed haploid cells, each individually synthesizing a non-identical polypeptide, are identified and then genetically crossed or fused. The resulting diploid strains are utilized to produce and secrete fully assembled and biologically functional hetero-multimeric protein.

Abstract: The present invention is directed towards isolated antibodies that bind to GRP78.

Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.

Abstract: The present application relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the application preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The application further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, to the uses of such immunoadsorbent materials for the purification of mammalian IgG antibodies and for therapeutic apheresis.

Abstract: The present invention is directed to novel heterodimeric antibodies.

Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.

Abstract: An object of the present invention is provide a method for sulfating a glycosaminoglycan in a solution of a non-organic solvent. In the present invention, sulfation reaction of a glycosaminoglycan is performed with a sulfating agent in a strongly basic solution of a non-organic solvent. In the present invention, pH of the strongly basic solution is preferably set to be 11.5 or higher. According to the present invention, for example, a glycosaminoglycan having heparin-like anticoagulant activity can be produced from N-acetylheparosan through one-pot procedure. In one embodiment, a sulfated glycosaminoglycan produced by the method of the present invention has a unique disaccharide composition and is expected to be a novel useful material.

Abstract: The invention provides a crosslinked polymer, a hydrogel, a water-based fracturing fluid comprising the same, and methods of making and using thereof. The crosslinked polymer of the invention is represented by formula (I), wherein * denotes a combining site with a polymer starting material and *? denotes an optional combining site with the polymer starting material, wherein the combining sites denoted by * and *? may be located in the same polymer molecule, or in different polymer molecules, but there are at least two combining sites located in different polymer molecules; X1 and X2, which may be the same or different, are independently an oxy (—O—) or imino (—NH—) group; X3 is an oxy (—O—) or imino (—NH—) group when *? denotes a combining site with the polymer starting material, or X3 is a halogen, NH2 or OH when *? isn't a combining site with the polymer starting material.

Abstract: An object of the present invention is to provide a novel catalyst for olefin (co)polymer production, which has high activity without using a large amount of a cocatalyst and is aimed for obtaining a particulate olefin (co)polymer. The invention relates to an olefin polymerization catalyst which comprises: a solid carrier (1) that has been brought into contact with a specific compound; and a metal catalyst component (2) that contains a transition metal compound (C) containing a transition metal M belonging to Group 9, 10, or 11 of the periodic table and has a reactive group Ra.

Abstract: Polyethylene composition for injection molding with a beneficial balance of environmental stress cracking resistance and impact resistance in combination with low warpage and beneficial processing behavior, said composition having the following features: 1) density of 0.945 g/cm3 or higher; 2) MIE from 1 to 30 g/10 min.; 3) ratio MIF/MIE from 15 to 30; 4) ER values from 0.40 to 0.52.

Abstract: Methods for reinforcing chromium catalysts by the deposition of additional silica are disclosed herein. The resultant silica-reinforced chromium supported catalysts can be used to polymerize olefins to produce, for example, ethylene based homopolymers and copolymers with higher molecular weights and additional long chain branching.

Abstract: An oxygen permeable polymer has the following formula: wherein RS is a non-sulfonyl halide portion of a sulfonyl halide monomer or polymer; XP is —NH or —NHCO; A is an optionally substituted alkyl; L is 0, 1 or 2; m is 2 or 3; Z is H or CH3; and n is 5-m. The polymer can be used in air separation devices, air concentrators, and in electrodes for electrochemical devices.

Abstract: There is provided a process for preparing a branched conjugated diene polymer by copolymerizing 1 to 100% by weight of a branched conjugated diene compound (1) monomer: wherein R1 is an aliphatic hydrocarbon having 6 to 11 carbon atoms, with 99 to 0% by weight of a conjugated diene compound (2) monomer: wherein R2 and R3 are the same or different and each is a hydrogen atom, or the like, and/or 99 to 0% by weight of a vinyl compound (3) monomer: wherein R4 is an aliphatic hydrocarbon group having 6 to 10 carbon atoms, or the like, wherein the process comprises a step of polymerizing by adding a monomer solution successively into a catalyst solution. The branched conjugated diene polymer is useful as a rubber component for a tire for improving processability.

Abstract: The present disclosure relates to a single-pot multi step process for the preparation of a shape controlled pro-catalyst. The process comprises the steps of: i. reacting magnesium metal and at least one alkanol to obtain spheroidal magnesium alkoxide; ii. treating the spheroidal magnesium alkoxide with at least one transition metal tetrahalide, at least one organic modifier, and optionally, at least one in-organic modifier in the presence of at least one solvent to obtain a reaction mixture; iii. cooling, settling the reaction mixture and decanting the supernatant; iv. adding at least one transition metal tetrahalide, at least one solvent and optionally, at least one organic or inorganic modifier; and v. iterating steps (iii) and (iv) to obtain the shape controlled pro-catalyst.

Abstract: Provided is a method of preparing polybutadiene which may improve productivity by minimizing a plugging phenomenon during the preparation of polybutadiene and increasing a conversion rate.

Abstract: The present invention relates to a process for the preparation of ethylene polymers using a number of reactors arranged in series comprising the steps in which a) ethylene, a diluent, a catalyst, a co-catalyst and optionally comonomers and hydrogen are introduced into a first reactor, b) polymerization of ethylene and optionally comonomers is carried out in the reaction mixture of said first reactor to make ethylene polymers, c) reaction mixture is discharged from said first reactor, d) said reaction mixture and fresh ethylene and optionally comonomers and hydrogen are introduced into the consecutive reactor to make additional ethylene polymers, e) said reaction mixture is discharged from said consecutive reactor and introduced into the further consecutive reactor, if any, with fresh ethylene and optionally comonomers and hydrogen to make additional ethylene polymers, steps c) and d) are repeated until the last reactor of the series, f) reaction mixture is discharged from last reactor of the series and ethyl

Abstract: This invention relates to copolymer compositions of poly(vinylidene fluoride-2,3,3,3-tetrafluoropropene) copolymers. The copolymers formed have excellent optical properties, corrosion resistance and electrical properties, with very low haze. Tetrafluoropropene monomer units may be present at from 0.5 to 60 weight percent of the copolymer.

Abstract: The present invention relates to a process comprising the steps of reacting a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component, and at least one diluent to form an ophthalmic device having an advancing contact angle of less than about 80°; and contacting the ophthalmic device with an aqueous extraction solution at an elevated extraction temperature, wherein said at least one diluent has a boiling point at least about 10° higher than said extraction temperature.

Abstract: The present invention relates to multi-arm salt-tolerant star macromolecules, and methods of preparing and using the same. In one aspect of the invention, a salt-tolerant star macromolecule is capable of providing salt-tolerance to an aqueous composition.

Abstract: According to the present invention, there is provided a resol phenolic resin for a friction material wherein the resol phenolic resin has a structural unit A represented by Formula (1) and a structural unit B represented by Formula (2): wherein in Formula (1), m represents an integer of 1 or more; in a case where m is 1, R represents a methylol group; and in a case where m is 2 or more, R's independently represent a hydrogen atom or a methylol group and at least one R is a methylol group; and wherein in Formula (2), n represents an integer of 1 or more; in a case where n is 1, R represents a methylol group; and in a case where n is 2 or more, R's independently represent a hydrogen atom or a methylol group and at least one R is a methylol group.

Abstract: The present invention relates to a method for increasing the reactivity of lignin, wherein the method comprises the following steps: a) forming, under heating at a temperature of 71-94° C., an aqueous dispersion comprising alkali and lignin, wherein the alkali comprises a hydroxide of an alkali metal; and b) heating the dispersion formed in step a) at a temperature of 50-95° C. for producing alkalated lignin.

Abstract: A binder for capacitive deionization electrode is provided, which is formed by reacting a polyether polyol, a diisocyanate, and a diol having a hydrophobic side chain. The binder may bind an electrode material and to form a capacitive deionization electrode. The electrode material and the binder may have a weight ratio of 90:5 to 90:25.

Abstract: The present invention relates to polyester polyols obtainable or obtained by esterification of 10 to 70 mol % of at least one compound from the group consisting of terephthalic acid (TPA), dimethyl terephthalate (DMT), polyethylene terephthalate (PET), phthalic anhydride (PA), phthalic acid and isophthalic acid, 0.1 to 30 mol % of one or more fatty acids and/or fatty acid derivatives, 10 to 70 mol % of one or more aliphatic or cycloaliphatic diols having 2 to 18 carbon atoms or alkoxylates thereof, 5 to 70 mol % of a polyether polyol prepared by alkoxylating an aromatic starter molecule having a functionality of not less than 2, and of 0 to 70 mol % of a tri- or polyol other than the polyether polyol, all based on the total amount of the components used, wherein the amounts used of the components add up to 100 mol %.

Abstract: The present invention relates to a novel block copolymer of structure 1, wherein, A- is a block polymer chain, B is a block polymer chain, wherein, A- and B- are chemically different, covalently connected polymer chains, which are phase separable and the moiety X(Y(Z)b)a is a junction group, which comprises a surface active pendant moiety Y(Z)b wherein: a is an integer from 1 to 4 denoting the number of surface active pendant moieties Y(Z)b on X, b is an integer from 1 to 5 denoting the number of Z moieties on the linking moiety Y, X is a linking group between the A polymer block, the B polymer block and the moiety Y, Y is a linking group or a direct valence bond between X and Z; and Z is a moiety independently selected from, a fluorine containing moiety, a Si1-Si8 siloxane containing moiety or a hydrocarbon moiety with at least 18 carbons, and further wherein the junction group X(Y(Z)b)a has a surface energy less than that that of the block A and less than that of the block B.

Abstract: A novel synthetic route to new classes of polymeric coupling agents using substituted epoxy monomers is reported. In the presence of an initiating agent and tris(pentafluorophenyl)borane catalyst, substituted epoxy monomers bearing polyalkylene oxide and trialkoxysilane moieties undergo a ring-opening polymerization. The polymerization is highly versatile and allows for the fine-tuning of functional, structural, and architectural features of the resulting polymeric coupling agents. These new polyalkylene oxides substituted with organosilyl groups are capable of bonding to and modifying inorganic surfaces. The products of this invention form thin hydrophilic films.

Abstract: The present invention discloses a method for preparing glatiramer acetate, comprising: (1) dissolving L-alanine NCA, L-tyrosine NCA, L-glutamic acid-?-benzyl ester NCA, and L-?-trifluoroacetyl-lysine NCA in 1,4-dioxane as solvent, stirring until a clarified solution is formed; (2) adding diethylamine for catalysis, stirring at 20-25° C., then slowly pouring the reaction solution into water, collecting the produced white product; (3) adding the obtained product to a solution of hydrobromic acid in acetic acid, stirring at 23.0-25.0° C., pouring the reaction solution into purified water for quenching and stirring, subjecting the mixture to suction filtration to obtain a yellow solid, after repeating 3-5 times, subjecting the solid to blast drying to remove the moisture therein; and (4) dissolving the solid obtained in step (3) in a 1M piperidine aqueous solution at room temperature and stirring, subjecting the obtained solution to dialysis, adding glacial acetic acid to adjust the pH to 5.5-7.

Abstract: Disclosed is a moisture curable composition comprising a reactive or curable silicone; a crosslinker; an unreactive silicone; and at least of an initial strength-imparting agent and a plasticizer. The composition can have superior waterproofing property and weatherproofing property and allows easy installation on a substrate and easy peeling from the substrate.

Abstract: An addition curable resin composition comprising a silphenylene oligomer skeleton-bearing organosilicon compound having at least two alkenyl groups per molecule cures into a product having both a satisfactory hardness and crack resistance.

Abstract: A curable organopolysiloxane composition which is capable of maintaining the refractive index and gas barrier at a certain level by incorporating diphenyl group into a silicone resin and maintaining the phenyl content at a certain level.

Abstract: Disclosed herein are nanoactuating rotaxanes comprising a threading component, the threading component comprising a oligoviologen, and at least two macrocylic components, wherein the oligoviologen is threaded through each of the macrocylic components. Also disclosed are methods for making and using the rotaxanes.

Abstract: This invention relates to a cosmetic sponge and a method of providing a cosmetic sponge incorporating a non-denatured collagen and other additives for skin care, cleaning, and cosmetic application.

Abstract: The present invention relates to substrates comprising a crosslinked network of covalently attached antimicrobial and/or antibiofouling polymers. The crosslinked network of antimicrobial and/or antibiofouling polymers acts highly efficiently against pathogens, e.g. bacteria and fungi. Both the antimicrobial and the antibiofouling cross-linked polymer networks are preferably better resistant to mechanical damage than simple surface-immobilized polymer monolayers. The antimicrobial and/or antibiofouling polymers of the crosslinked network are preferably obtained by ring opening metathesis polymerization (ROMP) and exhibit a molecular weight of preferably more than 30,000 or even 100,000 g mol?1. The crosslinked network of antimicrobial and/or antibiofouling polymers is preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue-supporting) biomaterial, etc.

Abstract: A latex formulation for making elastomeric product, more particularly an elastomeric glove comprising a mixture of at least one base polymer, a cross-linker; and a pH adjuster, where the pH adjustor providing a pH range of 9.5 to 10.5. Still further, the present invention discloses a method for preparing a latex formulation for making elastomeric product, more particularly an elastomeric glove without using accelerators, zinc oxide and sulphur, which comprises the steps of mixing a base polymer with a pH adjuster, stirring the mixture for time period ranging from 20 minutes to 30 minutes, adding a cross-linker to the mixture, stirring said mixture for an hour, optionally adding at least one or more additive to said mixture, adding water to said mixture to achieve a total solid content (TSC) ranging in between 13% to 30% by w/w, allowing said mixture to mature.

Abstract: A prepreg having at least one layer of carbon fibers and a curable thermosetting resin system, the curable thermosetting resin system at least partly impregnating the at least one layer of carbon fibers, wherein the curable thermosetting resin system includes: a curable thermosetting resin including at least one epoxide group, the curable thermosetting resin having an epoxy equivalent weight of from 140 to 180 g/eq; a curing agent for curing the curable thermosetting resin, wherein the curing agent is present in the liquid phase and includes a cyanamide reactive group; and a rheology modifier for the curable thermosetting resin system, wherein the rheology modifier includes at least one of a thermoplastic resin and an inorganic particulate thickener or a mixture thereof.

Abstract: A method for producing a non-breathable micro-porous thermoplastic polymer film for outer covering of diapers and sanitary towels includes a dispersion step by mixture of mineral particles surface-covered with a hydrophobic layer of fatty acid, a base polymer and a co-polymer adhesive, wherein the co-polymer adhesive is selected to comprise the base polymer; and film forming step in a film extrusion line having a flat film extruder provided with an extrusion nozzle, wherein the mixture is fed to the flat film extruder forming the film, and hot stretching the film between the extrusion nozzle and the solidification of the formed film, thereby obtaining the non-breathable micro-porous film with pores sizing from 0.5 to 5 ?m without communication between the pores. The process requires less raw materials with a further reduction of film thickness, while giving a matt appearance to the film, thus making the usual micro-embossing step of the extrusion line unnecessary.

Abstract: A membrane having permselectivity for perchlorate ion is prepared using certain types of quaternary ammonium salts contained in a polymeric matrix material, which may be plasticized. Such membranes are useful in electrodialysis processes, whereby perchlorate-contaminated aqueous compositions are purified.

Abstract: A prepreg comprising at least one layer of carbon fibers and a curable thermosetting resin system, the curable thermosetting resin system at least partly impregnating the at least one layer of carbon fibers, wherein the curable thermosetting resin system comprises: a. a curable thermosetting resin including at least one epoxide group; b. a curing agent for curing the curable thermosetting resin, wherein the curing agent is present in the liquid phase and includes a cyanamide reactive group; c. an accelerator for accelerating the curing of the thermosetting resin by the curing agent, wherein the accelerator includes at least one urea reactive group; and d. a rheology modifier for the curable thermosetting resin system, wherein the rheology modifier is at least one of a thermoplastic resin and an inorganic particulate thickener or a mixture thereof.

Abstract: A three-dimensionally printed article comprises a build material and a support material, the support material comprising a hydroxypropyl methylcellulose having a DS of at least 1.0 and an MS of at least 0.6, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxypropoxyl groups. The support material can be removed from the build material by contacting the support material with water.

Abstract: Aspects of the invention include methods for modifying a surface of a non-porous hydrophobic polymer substrate having a backbone containing electrophilic linkages. In practicing methods according to certain embodiments, a liquid composition having a nucleophilic reagent and a catalyst is contacted with the surface of the non-porous hydrophobic polymer substrate and maintained in contact with the surface of the polymer substrate in a manner sufficient to convert at least a portion of the surface from hydrophobic to hydrophilic while retaining the mechanical and optical properties of the polymer substrate. Substrates, including containers, having one or more hydrophilic surfaces and kits suitable for practicing the subject methods are also described.

Abstract: Minimum Federal Safety Standards for corrosion control on buried oil and natural gas pipelines stipulate that metallic pipes should be properly coated and have impressed-current cathodic protection (ICCP) systems in place to control the electrical potential field around susceptible pipes. In certain examples described herein, electrically-conductive nanocomposites can be used and provide intrinsically-safe foam materials without the dielectric shielding issues of existing materials used to physically protect and stabilize buried pipelines. As cured or formed by customary spray applications, the nanocomposite foams described herein are directly compatible with ICCP functionality wherever foam contacts the metallic pipe. Various foam compositions and their use with underground pipelines are described.

Abstract: A method for producing a silica aerogel, includes: (i) adding an electroconductive polymer to the sol of an aqueous alkaline silicate solution to convert the sol to a gel; (ii) aging the gel to cause said gel to grow; (iii) hydrophobizing the gel; and (iv) drying the gel. Further provided is a silica aerogel including an electroconductive polymer. Still further provided is a heat-insulation material, including the above-described silica aerogel and fibers.

Abstract: In the manufacture of composite product, raw composite is layered on a shape or form and cured at a higher temperature. With some shapes, it is difficult or impossible to apply sufficient pressure to force and consolidate the composite material to adequately conform to the desired final shape during the curing process. The expandable tacky tape of this invention is comprised of a viscous medium incorporating thermally expandable material. Applied over the raw composite, the expandable tacky tape effectively forces the composite to conform to the desired shape during curing.

Abstract: Embodiments disclose a foamed, flame-proofed molded body, comprising at least one thermoplastic polymer including a zeolite material in an amount from 0.1 percent by mass to 5.0 percent by mass, based on the weight of the foamed polymer, wherein the thermoplastic polymer is selected from the group consisting of acrylonitrile butadiene styrene (ABS), styrene acrylonitrile (SAN), polystyrene (PS), polycarbonate (PC), polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polyamide (PA) or mixtures thereof. The foamed polymer further includes hydrous foam cells, and the zeolitic material is at least partially present in dehydrated form. Embodiments disclose a molding compound underlying the molded body, a method for foaming a thermoplastic polymer, and the use of the foamed molded body.

Abstract: The present invention relates to a polymer composition having low sensory impression of smell comprising a polypropylene and a calcium salt of phosphoric acid, wherein in said polymer composition the amount of said calcium salt of phosphoric acid is preferably such to accomplish a sensory impression of smell measured according to VDA 270 of at most 4.0.

Abstract: Compositions that include polymer and silane can be used in various finish compositions, especially finish compositions intended for use on hard, high gloss surfaces. The silane of the composition can be in the form of a silane group attached to a polymer backbone or as a distinct component. The polymer can be provided as an aqueous emulsion or suspension in a liquid. The polymer finish composition can be used as a floor care coating or as an architectural coating such as a paint or wood finish.

Abstract: The present invention relates to a plasticizer composition, a resin composition and methods for preparing the plasticizer composition and the resin composition, and provides a plasticizer composition capable of improving physical properties such as plasticizing efficiency, tensile and elongation retention, volatile loss and migration resistance, which are required for a plasticizer composition included in a vinyl chloride-based resin composition, to an equal or a higher level compared to existing plasticizer compositions, and a resin composition including the same.

Abstract: A composition comprising: A. 91.5 to 97.9% of a crosslinkable ethylene-based polymer, e.g., LDPE; B. 1 to 3% of an organic peroxide, e.g., dicumyl peroxide; C. 1 to 5% of a dielectric fluid, e.g., an alkylated naphthalene; and D. 0.1 to 0.5% of a coagent such as AMSD. The compositions exhibit high cure rates without any significant reduction in scorch resistance, heat ageing and electrical performance, and are particularly useful as insulation sheaths for medium and high voltage power cables.

Abstract: The invention relates to a composition comprising an organic material susceptible to oxidative, thermal or light-induced degradation and a compound of formula I-P, I-O or I-M Further embodiments are a compound of formula I-P, I-O or I-M, a process for protection of the organic material by the compound, the use of the compound for stabilizing the organic material, an additive composition comprising the compound, a process for manufacturing the compound and intermediates involved therein.