Abstract: A system and method, for measuring phase delay and amplitude of a near infrared signal emanating from tissue of an animal subject in response a near infrared signal input to such tissue, operate by processing a signal from an optical detector and a corresponding signal from an optical detector emulation circuit. In some aspects, the processed signals are fed into a phase delay detection system that provides an output thereof a digital measure of the phase delay of the received optical signal.

Abstract: A dental probe for determining the vitality of a tooth, comprising (A) a light emitter and (B) a light receiver, wherein the light emitter emits light from an emitter surface adapted to be positioned on a hard dental surface of a tooth, wherein the light receiver collects light incident on a receiver surface adapted to be positioned on a hard dental surface of the tooth so that the optical path of the light emitted from the light emitter passes at least through a portion of the pulp chamber of the tooth, characterized in that the light receiver comprises (a) a light shielding spacer member adjacent to the optical path for establishing and maintaining a distance of at least 50 ?m between the gum line and the optical path at the receiver surface, and in that the light emitter comprises (c) a light shielding spacer member adjacent to the optical path for establishing and maintaining a distance between the gum line and the optical path at the emitter surface, wherein the light shielding spacer member establishes

Abstract: The dental health assessment assisting apparatus includes a gray scale converter configured to convert a fluorescence image obtained by imaging fluorescence of a tooth irradiated with excitation light into a gray scale image, a gray scale value acquiring unit configured to acquire gray scale values of a reference point and a plurality of evaluation points in an image of the tooth in the gray scale image, a normalization unit configured to normalize the gray scale values of the plurality of evaluation points by the gray scale value of the reference point, and a dental health assessment data generator configured to generate dental health assessment data visually representing the gray scale value of the reference point and the gray scale values of the plurality of evaluation points which have been normalized.

Abstract: Photoacoustic targeting systems for intracellular recording. In one embodiment, the photoacoustic targeting system includes a light source, a micropipette electrode, an acoustic transducer, and a controller. The light source is configured to emit pulsed light. The micropipette electrode is configured to deliver the pulsed light to a target cell. The acoustic transducer is configured to receive photoacoustic signals generated due to optical absorption of light energy by the target cell. The controller is configured to determine a position of the micropipette electrode relative to the target cell based on the photoacoustic signals.

Abstract: There are described herein methods and apparatus for processing a physical signal, in particular for processing data obtained in relation to the physical characteristics of a user, in particular a female user. One or more sensors can be used to obtain the data, in particular indwelling thermometers, aural thermometers, blood pressure and heart rate monitors. There are also described herein methods and apparatus for analysing and further processing the data to obtain and provide health information in relation to the user, in particular in relation to the user's fertility or state of ovulation.

Abstract: A portable device is provided, including a wearable frame capable of switching at least between a first status and a second status for a user to wear on different body parts. In the first status, the wearable frame forms a wristband for the user to wear, and in the second status, the wearable frame forms a hair clip for the user to wear on head. The wearable frame is provided with a physiological status information collection unit, used to collect physiological status information of a skin or hair of the user; and an environment information collection unit, used to collect external environment information of an environment where the user is located; and a communication unit, used to send the physiological status information and the external environment information to an external terminal. A portable device assembly is also provided.

Abstract: A cardiac monitoring system includes a display, a blood pressure sensor configured to sense a blood pressure of an artery of a patient, an analog-to-digital converter (ADC) configured to convert a blood pressure signal from the blood pressure sensor to digital blood pressure data, a hardware processor, and a software code. The hardware processor executes the software code to identify cardiovascular metrics of the patient, including one or more of an aortic impedance and an aortic compliance of the patient, based on the blood pressure data, and to determine a stroke volume (SV) of the patient using a subset of the cardiovascular metrics including the aortic impedance and/or aortic compliance, as well as an additive factor. The additive factor is based on a meta-parameter including a weighted sum of combinatorial parameters, each combinatorial parameter including another subset of the cardiovascular metrics.

Abstract: A coronary artery load detection method includes: (S1) obtaining the cross-sectional area of a reference cavity, and separately obtaining voltage values of a primary device at a location corresponding to the cross-sectional area of the reference cavity in a low frequency state and a high frequency state; (S2) separately obtaining voltage values of the primary device at the location of a bottom end or a top end of a to-be-detected object in the low frequency state and the high frequency state under the same current; (S3) driving the primary device to move at a constant speed, and obtaining a voltage value of the primary device during the movement in the low frequency state under the same current; and (S4) obtaining the cross-sectional area of each location of the to-be-detected object according to a preset fixed current value, the cross-sectional area of the cavity, and the obtained voltage values.

Abstract: A vascular sensor system includes a vascular sensor configured to monitor a blood vessel parameter and to output a signal representative of the measured parameter. A computing system is configured to receive the signal representative of the measured parameter. The computing system is programmed to process the received signal and evaluate a medical condition based on the processed signal.

Abstract: A measurement sensor package and a measurement sensor improve reliability in strength and other aspects. A measurement sensor package includes a substrate, a lid, a ground conductor layer, a metallic thin layer, and a bond. The ground conductor layer and the metallic thin layer are arranged inside the bond that extends continuously as viewed through from above. The bond directly bonds a first main surface of a substrate body and a facing surface of the lid together along the entire periphery. This improves the reliability in strength.

Abstract: A bio-information processing apparatus may include: a bio-signal measurer configured to measure a bio-signal; a bio-information receiver configured to receive first bio-information; and a processor configured to estimate second bio-information based on the bio-signal, and to correct the second bio-information based on measurement circumstances of the first bio-information and the second bio-information.

Abstract: A method for estimating blood pressure of a care recipient includes establishing a pre-maneuver reference value of blood pressure and a companion nonreference value of blood pressure, subjecting the care recipient to a maneuver, establishing a post-maneuver reference value of blood pressure and a companion post-manuever nonreference value of blood pressure, establishing an operational post-maneuver nonreference value of blood pressure, and adjusting the operational value as a function of the pre-maneuver and post-maneuver values. An associated apparatus includes a sensor, a processor and a memory which contains instructions.

Abstract: A biological information analysis device includes: an indicator extraction unit configured to acquire, from time-series data regarding blood pressure waveforms consecutively measured by a sensor that is configured to be worn on a body part of a user and to be capable of non-invasively measuring a blood pressure waveform for each heartbeat, data regarding a blood pressure waveform in a pre-exercise period that is a period of time before the user performs exercise, and data regarding a blood pressure waveform in a post-exercise period that is a period of time after the user performs the exercise, and extract an indicator indicating the influence of the exercise on the user's cardiac function, based on characteristics of the blood pressure waveform in the pre-exercise period and characteristics of the blood pressure waveform in the post-exercise period; and a processing unit configured to perform processing that is based on the indicator thus extracted.

Abstract: A tonometer for continuously monitoring arterial blood pressure of a patient, including a bracelet, a detection group mounted on the bracelet and arranged to detect a pressure signal. The detection group has a plurality of pressure sensors arranged to detect a pressure signal associated with the blood pressure wave of the patient. A pressure sensor is positioned in proximity of the radial artery of the patient, at the opposite side of the radial bone. A touching group is interposed between the detection group and the radial artery, and equipped with a plurality of protuberant members, each of which is associated with a pressure sensor, and arranged to be positioned into contact with the skin of the patient, in such a way to exert a predetermined force on the radial artery.

Abstract: A method (200) of deriving systolic blood pressure and/or diastolic blood pressure of a subject is disclosed. The method comprises: (i) receiving (202) data related to at least one cardiac cycle of a bio-signal from the subject; (ii) calculating (208) a rise time and a fall time of the at least one cardiac cycle based on the received data; (iii) calculating (208) a parameter derived from a function of the rise time and fail time; and (iv) determining (210) the systolic blood pressure and/or diastolic blood pressure of the subject based on the calculated parameter. A related apparatus is also disclosed.

Abstract: The present invention relates to a pulse diagnosis apparatus, and more particularly, to a pulse diagnosis apparatus which includes a blood flow rate sensor, continuously observes a blood flow rate change of a user, and diagnoses a pulse of the user by using a pulse model generated by using a deep neural network (DNN) and a pulse diagnosis method used in the pulse diagnosis apparatus.

Abstract: Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods include evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

Abstract: A stimulation device includes an adapter component to increase the usability of the stimulation device. The adapter may be a bipolar adapter arranged to connect to the housing of the stimulation device. The adapter may include a clip having a first channel configured to receive an operative element therein and a second channel having a return operative element therein. The return operative element is in electrical communication with an electrical circuit of said stimulation control device. Alternatively, the adapter may be a percutaneous adapter comprising a connector configured to connect to an operative element of a stimulation device and a lead wire connected to the connector. A needle may be connected to the lead wire to deliver a electrical stimulation signal to a target tissue located beneath the skin of a subject patient.

Abstract: An excitement propagation visualization apparatus detects an excitement propagation wave front for each analysis time on the basis of excitement propagation data indicative of a potential generated by excitement propagation. Next, the excitement propagation visualization apparatus detects for each analysis time an intersection of a straight line passing through a first point inside a heart and a second point outside the heart and the excitement propagation wave front. Furthermore, the excitement propagation visualization apparatus generates for each analysis time a display object associated with the intersection of the straight line and the excitement propagation wave front. In addition, the excitement propagation visualization apparatus draws the display object generated for each analysis time at a position of the associated intersection in a drawing area indicative of an analysis space.

Abstract: An implantable medical device includes a memory storing criteria for transitioning between states of a cardiac cycle model, the states including a P-wave state. The device also includes sensing circuitry that senses a cardiac signal that varies as a function of a cardiac cycle of a patient, and also includes processing circuitry coupled to the sensing circuitry. The processing circuitry is configured to detect an R-wave in the sensed cardiac signal, to determine an elapsed time since the detection of the R-wave, to determine one or more morphological values of a post-R-wave segment of the cardiac signal to compare the elapsed time and the one or more morphological values to the stored criteria for transitioning between the plurality of states of the cardiac cycle model, and to detect a P-wave in the sensed cardiac signal in response to a transition to the P-wave state of the cardiac cycle model.

Abstract: A frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in at least two different frequency bands, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body.

Abstract: A body worn patient monitoring device includes a flexible substrate having a plurality of electrical connections adapted to be coupled to a skin surface to measure physiological signals. The flexible substrate is adapted to be directly and non-permanently affixed to a skin surface of a patient and configured for single patient use. A communication-computation module, removably attached to an upper surface of the flexible substrate, is configured to receive physiological signals from the flexible substrate and includes a microprocessor that is configured to process and analyze the physiological signals. A series of resistive traces screened onto the flexible substrate are configured as at least one series current-limiting resistor to protect the communication-computation module.

Abstract: Disclosed herein are methods and devices used to recognize the extent and deepness of infarcted tissue, such as chronic myocardial infarcted tissue. This applies to the heart tissue, but can also be used to assess cicatricial processes in other organs. Examples include injecting pulses of alternating current at a broadband of frequencies while measuring the voltage signal continuously (at a very high sampling rate) to obtain the electrical impedance (Z(f,t)) during the entire cardiac cycle. The impedance measurements may be taken using an intracavitary electrocatheter.

Abstract: A physiological information processing apparatus includes a processor and a memory storing computer-readable instructions. When the computer-readable instructions are executed by the processor, the apparatus obtains physiological information data indicative of physiological information of a subject, obtains RR interval data including a plurality of RR intervals based on the physiological information data, identifies an RR interval indicative of arrhythmia, and displays the RR interval data as plotted points on a two-dimensional coordinate system having one axis representing an n-th RR interval and another axis representing an (n+1)-th RR interval. The RR interval data is displayed on the two-dimensional coordinate system such that a visual mode of a plurality of first plotted points associated with the RR interval indicative of arrhythmia and a visual mode of plotted points of the RR interval data other than the plurality of first plotted points are different from each other.

Abstract: The present invention provides a medical electrode comprising a conductive metal base comprising a plate element and a boss formed on the plate element and a conductive support cylinder separate from the conductive metal base. The conductive support cylinder is rotatably mounted to the conductive metal base while remaining in electrical communication with said conductive metal base. The present invention also provides a limb clamp for an ECG device. According to the present invention, it is possible to prevent bending of the cable connecting with the medical electrode, thereby avoiding cable failure.

Abstract: An analyte monitoring system and methods for extending the life of a sensor in an analyte monitoring system. The analyte sensor may include an analyte sensor and a transceiver. The analyte sensor may include an indicator, a detector, and an amplifier. The indicator may be configured to exhibit one or more detectable properties based on an amount or concentration of an analyte in proximity to the indicator. The detector may be configured to detect one or more of the detectable properties and output an analyte signal indicative of the amount or concentration of the analyte in proximity to the indicator. The amplifier may be configured to amplify the analyte signal. The transceiver may be configured to adjust a gain of the amplifier. The transceiver may be configured to additionally or alternatively adjust a drive current of a light source of the analyte sensor.

Abstract: There is provided a device for measuring a user's oxygen-consumption. The device includes a venturi tube. The venturi tube has a first tapered portion, a second tapered portion that is more tapered compared to the first tapered portion, and a constriction between the portions thereof. The device includes at least one pressure sensor in communication with the constriction and the first tapered portion of the venturi tube. The device includes an oxygen sensor in communication with the constriction and the first tapered portion of the venturi tube.

Abstract: There is provided a method, apparatus, computer program product and wearable device for monitoring volumetric change of a lung during a breathing cycle by using an electronic signal. The method comprises: receiving by a receiver an electronic signal transmitted from a transmitter, wherein at least part of a path of the signal contours at least part of a chest wall of the lung; determining by the receiver measurements of an attribute of the signal received at the beginning and the end of a time interval during the breathing cycle; calculating by a processor a change in length of the signal path during the time interval based on the measurements of the attribute of the signal received at the beginning and the end of the time interval; and calculating by the processor a volumetric change during the time interval based on the change in signal path length.

Abstract: Disclosed are a method and an apparatus for jaundice diagnosis based on an image. The method for jaundice diagnosis based on an image includes: receiving a jaundice diagnostic image acquired by photographing both a specific body part of a user and a reference object at a place where the user is positioned at present; generating color distortion information indicating a color distortion degree of the reference object included in the jaundice diagnostic image; generating a jaundice diagnostic correction image by correcting color distortion of the jaundice diagnostic image based on the color distortion information; and diagnosing a jaundice symptom for the user by using the jaundice diagnostic correction image.

Abstract: Regarding acceleration on each of three axes Gx, Gy, and Gz calculated by a microcomputer, acceleration on one of the three axes is acceleration in a vertical direction perpendicular to the ground, and acceleration on each of the other two axes is acceleration in a direction parallel to the ground, the other two axes being perpendicular to each other. A type of action of the human body in a predetermined period is determined by comparing a predetermined threshold value with the acceleration in the vertical direction in the predetermined period.

Abstract: An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring the emission spectrum of the fluorescent analyte when (i) the difference of emission intensities at the excitation wavelength ranges of the fluorescent analyte is greater than that of background fluorophores, and (ii) when blood absorbance at the two excitation wavelength ranges is similar. An apparatus and method for measurement of a fluorescent analyte concentration in the blood of a patient is provided.

Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

Abstract: The non-invasive biolipid concentration meter comprises: an irradiator (2) that emits light at a given intensity toward the inside of a living body from outside; a light intensity detector (3) that is disposed at a given distance from a position (21) irradiated with the light from the irradiator (2) and that determines the intensity of light emitted from the living body; a scattering coefficient calculator (4) that calculates the coefficient of light scattering within the living body on the basis of the light intensity determined with the light intensity detector (3); and a lipid concentration calculator (5) that calculates the lipid concentration in the living body on the basis of the coefficient of light scattering.

Abstract: A system for transdermal alcohol sensing to be worn near a skin surface of a user, including: an alcohol sensor; a microporous membrane; a housing coupled to the alcohol sensor and the membrane, defining a volume between the alcohol sensor and a first membrane side, and fluidly isolating the volume from a second membrane side opposing the first membrane side; an electronics subsystem electrically coupled to the alcohol sensor, operable to power and receive signals from the alcohol sensor; and a fastener operable to position the second membrane side proximal the skin surface.

Abstract: Presented herein are devices for collecting and/or channeling a biofluid (e.g., sweat, tears, saliva) and detecting and/or quantifying one or more biomarkers in the biofluid. The one or more biomarkers may include, for example, ions, salts thereof, hormones and/or steroids, proteins, metabolites and organic compounds. In certain embodiments, the devices described herein include a specially designed interface and a zero-energy micro pump that allow the device to be comfortably affixed directly to the skin of a user while biofluid is efficiently and non-invasively collected from the skin of the user. In certain embodiments, the biofluid collection and sensing device is housed on or in another wearable device, such as a wrist band or a smart watch. In certain embodiments, the devices described herein are disposable (e.g., after a certain period of use and/or wear the device can be disposed and replaced with a low-cost replacement).

Abstract: Introduced here are techniques for developing personalized retroactive insights into how contextual factors can affect glycemic responses. The personalized retroactive insights can be made available to the corresponding individual so that they can examine the impact certain contextual events have had on blood glucose level. A contextual event represents an activity or a circumstance that is related to glycemic response. Rather than state the absolute amount of certain molecules (e.g., carbohydrates, protein, or fat) in a foodstuff, an insight detection platform can instead interpret disparate data types to discover the effect certain contextual events have on blood glucose level.

Abstract: Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.

Abstract: The present invention provides method and apparatus for minimally-invasive capillary blood extraction comprising an apparatus capable of the harnessing the energy from frequent natural mammalian movements and then converting it into forces needed to execute skin lancing, specifically an insertion of a lancet in the body of the mammal. The apparatus consists of a rotational and a translational member which work together to effectively translate an angular displacement of the rotational element caused by mammalian movements to translational displacement of a sliding element at an angle to the plane which the force from the mammal was applied in. The ability of the invention to harness free energy and efficiently use that energy for actuating a lancet and facilitating blood extraction allows for the miniaturization of blood sampling technology into a wearable device.

Abstract: A system and method for detection and analysis of learner's/performers cognitive flow have been provided. The system is configured to measure the cognitive state of the performer, while they are performing tasks of various complexity levels, using physiological responses like brain activation, heart rate variability and galvanic skin response. The system uses a Bayesian network based framework to probabilistically evaluate the cognitive state of the learner from the difficulty levels of the tasks, IQ level of the learner and observations made using the physiological sensing. The system also measures the actual cognitive state using a questionnaire. The predicted cognitive state and the actual cognitive state is compared and based on the outcome of comparison a relevant step is taken.

Abstract: A mood score calculation apparatus has a memory device that stores a manipulation history of a user on a predetermined device and a arithmetic device that classifies the manipulation history into any one of a verbal task and a spatial task on the basis of a predetermined algorithm, calculates the user's mood score on the basis of a relative relationship between the manipulation histories for each of the verbal task and the spatial task specified in the classification, and outputs information on the mood score into a predetermined output target.

Abstract: A system, method and computer program product for augmenting, in real-time, queries/questionnaires administered to a subject by coupling the physiological response of the subject for a given question-answer pair. Further, a method/system augments/annotates answers to questionnaires/surveys/etc. with automatically detected physiological or emotional reactions of the person answering the question/survey/etc. In an embodiment, methods are implemented to: create an augmented representation of question-answer-emotion (i.e., annotating questions/answers from assessments to physiological reactions); and consider the augmented representation and the user profile to suggest actions based on such associations.

Abstract: A driver condition detection device for a vehicle includes: a physical information acquisition unit that acquires physical information of a driver; a standard setting unit that sets, as a standard range, the physical information in a case where the driver is in an operable state for driving the vehicle; a correspondence relationship accumulation unit that accumulates a correspondence relationship between a deviation of the physical information from the standard range and a time interval to return to the standard range; a recovery time estimation unit that estimates a recovery time to return to the standard range from the physical information acquired by the physical information acquisition unit, based on the correspondence relationship; and a determination unit that determines that the driver is in an inoperable state for driving the vehicle when the recovery time is more than a predetermined allowance time.

Abstract: According to one aspect of the inventive concept there is provided a system for monitoring incontinence comprising: a urine sensitive circuit arranged to present a changed electrical characteristic when exposed to urine; a measurement circuit arranged to perform a measurement on a urine bladder of a wearer to determine at least one parameter which varies with a fill level of the urine bladder; a sensor arranged to determine an orientation and/or a movement of the sensor; and a processing circuit arranged to: determine whether the urine sensitive circuit has been exposed to urine; estimate an amount of urine released on to the urine sensitive circuit; and in response to determining that the urine sensitive circuit has been exposed to urine, record data representing said at least one parameter determined by the measurement circuit, an estimated movement and/or posture of the wearer based on an orientation and/or a movement determined by the sensor, and an estimate of the amount of urine released on to the urine

Abstract: The probe for measuring intravesical pressure includes a flexible tubular element of elongated conformation and having a first extremity comprising at least a supply mouth associable with the supply means of a fluid, a second extremity opposite to the first extremity, positionable inside the bladder of a patient along a direction of insertion, and a first sensing element and at least a second sensing element associated with the tubular element in the proximity of the second extremity and adapted to measure the pressure inside the patient's bladder.

Abstract: A system for modulating bladder function is disclosed. A system for evaluating the electrophysiological function of a bladder is disclosed. Methods for performing a controlled surgical procedure on a bladder are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. An implantable device for monitoring and/or performing a neuromodulation procedure on a bladder is disclosed.

Abstract: According to one aspect of the inventive concept there is provided a method of monitoring incontinence for a user, comprising: determining, using a urine sensitive circuit provided at an absorbent article and arranged to present a changed electrical characteristic when exposed to urine, whether the user has urinated on the absorbent article, performing, using a measurement circuit, a measurement on the urine bladder to determine a parameter which varies with a fill level of the urine bladder, and in response to determining that the user has urinated on the absorbent article, recording, by a processing circuit, data representing said parameter.

Abstract: A system and method are described for assessing muscle parameters (e.g., force(s) exerted, force dynamics, strength, voluntary muscle movement, etc.) in a diagnostic or therapeutic environment. The muscle parameter assessment system includes a force-gauging device and a computing device. The force-gauging device includes at least one pressure-sensing component (e.g., transducer, pressure sensor, etc.) configured to respond to a force applied by a subject and produce one or more output signals. The force-gauging device can further include electronic circuitry configured to convert the output signals into data indicative of a muscle parameter. The computing device is configured to build a muscle assessment protocol based on one or more patient characteristics and/or user input. The computing device is further configured to execute one or more muscle assessments via the force-gauging device, receive data from the force-gauging device, and determine one or more muscle measurements for a subject.

Abstract: A system and method for the non-invasive assessment of cutaneous autonomic nerve function through the application of external vibrational stimulus is disclosed. System embodiments comprising an electronic vibration source and photoplethysmographic (PPG) sensor enable measurement of vasomotor responses to vibrational stimuli. This response, facilitated by Pacinian channel-mediated stimulation of small fiber autonomic nerves, is quantified by PPG waveform analysis of transient skin vasoconstriction. Utilizing this normally elicited vasoconstriction reflex as the reference standard, small fiber autonomic nerve deficits revealed by absent or diminished vasomotor responses can be detected. Measurement of these deficits will enable rapid, non-invasive assessment of small fiber nerve degeneration in a variety of medical conditions including diabetes, hypothyroidism and chemotherapy-induced peripheral neuropathy.

Abstract: In one example, a system for measuring body movement in a movement disorder disease is provided. The system may comprise at least one processor and a memory storing processor executable codes, which, when implemented by the at least one processor, cause the system to perform operations comprising, at least receiving a video including a sequence of images and detecting at least one object of interest in one or more of the images. Feature reference points of the at least one object of interest are located, and a virtual movement-detection framework is generated in one or more of the images. The operations may include detecting, over the sequence of images, at least one singular or reciprocating movement of the feature reference point relative to the virtual movement-detection framework and generating a virtual path tracking a path of the at least one detected singular or reciprocating movement of the feature reference point.

Abstract: The present invention provides for a novel epicutaneous test plaster useful for the application of test substances for direct and continuous contact with the skin of a human patient.