Patents Issued in June 4, 2019
  • Patent number: 10307497
    Abstract: A disinfectant appliance has a plurality of chlorite absorbent particles, a plurality of redox resin particles, and at least one absorbent material combined such that the absorbent material allows and can promote: infusion of water into the disinfectant appliance; release of the chlorite from the chlorite absorbent particles into the water to form a chlorite comprising solution; contacting of the chlorite comprising solution with the redox resin particles; and the expulsion of ClO2 comprising solution from the disinfectant appliance onto a surface to be disinfected. The disinfectant appliance can include a storage section and can include a handle. The disinfectant appliance can be in the form of a wipe or sponge that can be contacted with a surface suspected of being infected.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: June 4, 2019
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: David Ernest Richardson
  • Patent number: 10307498
    Abstract: The disclosed invention relates to a two-part liquid composition for cleaning and disinfecting a substrate, comprising: (A) a disinfectant medium comprising peracetic acid; and (B) a supplemental medium comprising a non-enzymatic cleaner, a corrosion inhibitor, and a chelator. The supplemental medium (B) may further comprise an enzymatic cleaner, a surfactant, a buffer, a pH modifier, or a mixture of two or more thereof. The substrate may be a medical device, for example, an endoscope.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: June 4, 2019
    Assignee: American Sterilizer Company
    Inventors: Phillip P. Franciskovich, Donald G. Rosenhamer, Kathleen A. Fix
  • Patent number: 10307499
    Abstract: A gas transfer system including a housing, a pressurized gas canister held by the housing, a first passageway in fluid communication with the pressurized gas canister and configured to supply pressurized pre-sterilization gas from the pressurized gas canister to a fluid flow component, a gas discharge canister held by the housing; and a second passageway in fluid communication with the gas discharge canister and configured to supply post-sterilization gas from the fluid flow component to the gas discharge canister. The system may include devices directed to disinfection of fluid flow components, members, or fluid zones, and methods for their use. Additional related devices, systems and methods are provided.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: June 4, 2019
    Assignees: BÜRKERT CONTROMATIC CORP., BÜRKERT WERKE GMBH & CO. KG
    Inventors: Harm Stratman, Heinz Duemmler, Ray M. Frey
  • Patent number: 10307500
    Abstract: A system and method for neutralizing a biological organism is provided. The system includes a first element is made from paraformaldehyde. A second element is configured to generate heat and decompose the paraformaldehyde into formaldehyde gas. In one embodiment, the second element is configured to have an exothermic and self-sustaining alloying reaction in response to being thermally energized by an initiator.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: June 4, 2019
    Assignee: ENSIGN-BICKFORD AEROSPACE & DEFENSE COMPANY
    Inventor: Richard M. Kellett
  • Patent number: 10307501
    Abstract: Provided is a decontamination apparatus that includes a motorized base with a transport system that is operable to autonomously move the decontamination apparatus. A plurality of UVC bulbs, each of which emits UVC light, are supported at a vertical elevation above the motorized base. A controller controls operation of the transport system to move the decontamination apparatus along a desired route while the UVC bulbs are energized during a decontamination process.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: June 4, 2019
    Assignee: Diversey, Inc.
    Inventor: Roderick Dayton
  • Patent number: 10307502
    Abstract: The present invention provides a spill-resistant air freshener canister that includes: a supply vessel filled with aromatic liquid that has a threaded mouth sealed with a puncturable foil/polyethylene membrane; a cylindrical inner sleeve incorporating a socket that sealably engages the threaded mouth of the supply vessel, the sleeve also having a cylindrical axial aperture at the bottom of the socket, and at least one seepage aperture at the very bottom of the socket which enables liquid from inside the supply vessel to escape in a radially outward direction to the exterior of the inner cylindrical sleeve; a cylindrical wick surrounding the cylindrical inner sleeve; and an evaporator cage into which the cylindrical inner sleeve is inserted, the evaporator cage having a fully-enclosed bottom portion containing a central projecting blade that fits through the axial aperture at the bottom of the socket. The bottom portion is ultrasonically welded to the bottom of the cylindrical inner sleeve.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: June 4, 2019
    Assignee: Silver Coast, Inc.
    Inventor: Rami Sidawi
  • Patent number: 10307503
    Abstract: An automatic dispensing device for volatile fluid operable to apply one or more agent to a local environment for more than 14 days. Preferred devices dispense a first agent for air freshening, and may optionally dispense a second agent, such as a drain cleaner. A workable drain cleaner is structured to permit a slow release of drain cleaning agent. A dispensing device may nonexclusively operate by evaporation of volatile fluid from a polymer or rubber-like carrier material that is infused with the volatile fluid; gravity-induced drip from a bulk supply of volatile fluid through a small orifice onto an emanator; osmotic transfer of volatile fluid from a bulk supply; gas-pump drive of volatile fluid at controlled pressure; or diffusion of volatile fluid through a wall of a container of bulk volatile fluid; and combinations thereof.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: June 4, 2019
    Assignee: Microlin, LLC
    Inventor: Ashok V. Joshi
  • Patent number: 10307504
    Abstract: A disinfecting apparatus may include a shelf securable to a wall; a mount configured to secure the shelf to the wall; at least one UV light source coupled to the shelf, the UV light being configured to sanitize air and surfaces in close proximity to the UV light source; and a programmable controller being operatively coupled to the motion detector, the controller being configured to cause cause at least one of energization and de-energization of the UV light source upon a predetermined event. A method of safely disinfecting or sterilizing air and surfaces may include the apparatus and may further provide UV light in the range of 250-290 nm and interruption of the generation of UV light in response to the predetermined event.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: June 4, 2019
    Assignee: SteriLumen, Inc.
    Inventor: Max Munn
  • Patent number: 10307505
    Abstract: A wound dressing material for controlled activation of a wound healing therapeutic compound in the presence of a protease enzyme in a wound fluid, the material comprising: a medically acceptable polymer; a wound healing therapeutic agent; an inhibitor of the protease enzyme; and a linker group which is cleavable by the protease enzyme wherein the activities of both the wound healing therapeutic agent and the inhibitor increased by contacting the wound dressing material with a would fluid containing the protease enzyme. For example, the enzyme may be a matrix metalloproteinase, the therapeutic agent may be a reactive oxygen scavenger, and the inhibitor may be a tissue inhibitor of metalloproteinase (TIMP).
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: June 4, 2019
    Assignee: KCI USA, INC.
    Inventors: Breda Mary Cullen, Sara Jayne Gregory
  • Patent number: 10307506
    Abstract: The disclosed process for continuously producing a water-absorbing resin comprising a plurality of joined continuous steps; a polymerization step of polymerizing an aqueous unsaturated monomer solution, a drying step of drying a particulated water-containing gel-like crosslinked polymer obtained in a finely crushing step during the polymerization or after the polymerization, a pulverizing step after the drying, a classification step after the drying, and a surface treatment step for the water-absorbing resin powder after the classification step. In the process, with some of the above steps kept running, the other steps are interrupted, and subsequently all the steps are restarted.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: June 4, 2019
    Assignee: NIPPON SHOKUBAI CO., LTD.
    Inventors: Syuji Kanzaki, Sumio Okuda, Kunihiko Ishizaki, Satoshi Matsumoto
  • Patent number: 10307507
    Abstract: Hydrocolloid compositions, wound dressings, methods of using such compositions and such wound dressings, and methods of forming such hydrocolloid compositions, wherein the hydrocolloid compositions include a hydrophobic, unsaturated, elastomeric polymer; a hydrocolloid absorbent; and a hydrophilic polymer including an unsaturated polymer backbone having polyalkylene ether groups bonded thereto.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: June 4, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Herbert C. Chiou, Hae-Seung Lee
  • Patent number: 10307508
    Abstract: A vacuum mixing system for the mixing of polymethylmethacrylate bone cement comprising at least one cartridge (4) having an evacuatable internal space (5) for the mixing of the bone cement, the internal space (5) of which comprises a cylindrical swept volume, a mixing element (12) that is arranged in the internal space (5) of the cartridge (4) such as to be mobile and can be operated from outside the vacuum mixing system in order to mix the content in the internal space (5) of the cartridge (4), and a dispensing plunger (2) having a cylindrical external circumference whose first base surface borders a base surface of the internal space (5) of the cartridge (4) and which can be or is locked to the cartridge (4) in detachable manner and which, in the detached state, is mobile in the cylindrical region of the internal space (5) of the cartridge (4).
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: June 4, 2019
    Assignee: HERAEUS MEDICAL GMBH
    Inventor: Sebastian Vogt
  • Patent number: 10307509
    Abstract: The invention discloses a pharmaceutical hemostatic liquid foam base preparation comprising albumin as foaming agent and a fibrinogen precipitating substance and optionally a coagulation inducing agent, wherein albumin as foaming agent is present in native form; a method for the production of a transient hemostatic liquid foam; the transient hemostatic liquid foam; and a kit for making the foam.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: June 4, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Andreas Goessl, Katarzyna Gorna
  • Patent number: 10307510
    Abstract: Tissue products lacking a desired percentage of immunogenic epitopes, such as galactose alpha-1,3 galactose epitopes, are provided. Methods of making and using the tissue products are also provided.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: June 4, 2019
    Assignee: LifeCell Corporation
    Inventors: Hui Xu, Li Ting Huang, Hua Wan, Rick T. Owens, Nathaniel Bachrach
  • Patent number: 10307511
    Abstract: The present invention generally relates to bioactive composites of polymer and glass and, more particularly, to bioactive implants. The present invention also relates to methods of manufacturing bioactive composites. The bioactive composite finds utility in a variety of load-bearing clinical applications including spine, orthopaedic and dental procedures.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: June 4, 2019
    Assignee: Orthovita, Inc.
    Inventors: Theodore D. Clineff, Marissa M. Conrad, Matthew B. Havener, James P. Murphy, Zachary S. Szczerbinski
  • Patent number: 10307512
    Abstract: The present invention relates to a process for preparing a crosslinked gel of at least one polysaccharide or a salt thereof, comprising at least the steps consisting in: a) providing a solution formed from an aqueous medium comprising at least said polysaccharide(s) or a salt thereof in a non-crosslinked form, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, 1,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt; b) crosslinking the solution from step a) and, where appropriate; c) recovering said crosslinked gel formed.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: June 4, 2019
    Assignee: TEOXANE
    Inventors: Francois Bourdon, Stephane Meunier
  • Patent number: 10307513
    Abstract: Provided herein are methods of making a biomimetic hydrogel scaffold comprising a polycation and a polyanion. Also provided are anisotropic biomimetic hydrogel scaffold compositions suitable for use in tissue growth, including bone, muscle, and nerve growth an optionally comprising a carbon allotrope such as graphene. Also provided are methods of producing tissue comprising growing tissue on the biomimetic hydrogel scaffold comprising a polycation and a polyanion.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: June 4, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventor: Shilpa Sant
  • Patent number: 10307514
    Abstract: The present invention provides gradient porous scaffolds for bone regeneration and osteochondral defect repair, methods for making such gradient porous scaffolds, and methods for using the gradient porous scaffolds.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: June 4, 2019
    Assignee: University of Connecticut
    Inventors: Syam P. Nukavarapu, Cato T. Laurencin, Ami R. Amini, Deborah L. Dorcemus
  • Patent number: 10307515
    Abstract: Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: June 4, 2019
    Assignee: Arsenal Medical Inc.
    Inventors: Upma Sharma, Irina Gitlin, Gregory T. Zugates, Adam Rago, Parisa Zamiri, Rany Busold, Robert J. Caulkins, Toby Freyman, Quynh Pham, Changcheng You, Jeffrey Carbeck
  • Patent number: 10307516
    Abstract: Leak location devices and methods of using leak location devices that can be used in conjunction with negative pressure wound therapy systems are disclosed. In some embodiments, a leak location device can include a microphone for detecting sound pressure produced by a leak. Detected sound pressure can be compared to a threshold, which can correspond to background or ambient sound pressure. Background or ambient sound pressure can correspond to sound produced by a negative pressure source. The leak detection device can include a display configured to visually depict the detected sound, and a light source which creates a visual depiction of the coverage angle of the microphone.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: June 4, 2019
    Assignee: Smith & Nephew, Inc.
    Inventors: Paul Aceto, Kealoha Young Deutch, Joseph Gordon, Luke Hagan, William Joseph Jaecklein, Bill Kane, Dino Kasvikis, Corey Libby, Jacob A. Marks, Michael Salame, Jared Schneider
  • Patent number: 10307517
    Abstract: Negative pressure wound therapy apparatuses and dressings, and systems and methods for operating such apparatuses for use with dressings are disclosed. In some embodiments, controlling the delivery of therapy can be based on monitoring and detecting various operating conditions. An apparatus can have a controller configured to monitor the duty cycle of a source of negative pressure and, based on the monitored duty cycle, determine whether a leak is present. The controller can be configured to provide an indication that a leak is present. For example, the controller can be configured to suspend and/or pause the delivery of therapy, and to restart the delivery of therapy due to a timeout, request from a user, etc. In addition, the controller can be configured to pause and/or restart the delivery of therapy upon a request from the user, such as in response to the user operating a switch.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: June 4, 2019
    Assignee: Smith & Nephew PLC
    Inventors: Julie Allen, Ben Alan Askem, Sarah Jenny Collinson, Richard Thomas Hughey, Derek Nicolini
  • Patent number: 10307518
    Abstract: A system for applying reduced pressure to tissue includes a multi-lumen reduced pressure delivery tube having a proximate end, a distal end, a primary lumen extending through the conduit from the proximate end to the distal end, and an ancillary lumen extending through the conduit from the proximate end to the distal end. A vacuum pump is coupled to the proximate end of the primary lumen, and a reduced pressure adapter is coupled to the distal end of the reduced pressure delivery tube. The adapter includes channels to direct liquid away from the ancillary lumens and into the primary lumen.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: June 4, 2019
    Assignee: KCI Licensing, Inc.
    Inventors: Keith Patrick Heaton, Timothy Mark Robinson, Christopher Brian Locke
  • Patent number: 10307519
    Abstract: A balloon dilation catheter includes a substantially rigid inner guide member and a movable shaft coupled to a balloon that is slidably mounted on the substantially rigid inner guide member. To treat a sinus cavity of a subject using the balloon dilation the substantially rigid inner guide member is advanced into a drainage pathway of the sinus (e.g., frontal recess or maxillary sinus) of the subject via a nasal passageway. The shaft and balloon are advanced in a distal direction over the substantially rigid inner guide member to place the balloon in the drainage pathway. The balloon is inflated to expand or otherwise remodel the drainage pathway.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: June 4, 2019
    Assignee: ENTELLUS MEDICAL, INC.
    Inventors: John R. Drontle, Anthony J. Hanson, Paul Lesch
  • Patent number: 10307520
    Abstract: An example assembly for use with a vacuum system and an esophageal positioning device esophageal positioning device includes an introducer, in which the esophageal positioning device includes a handle, a first segment, a second segment and an articulation driving mechanism. The first segment being coupled to the handle. The second segment being pivotally connected to the first segment. The articulation driving mechanism being configured to pivot the second segment about the first segment upon articulation.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 4, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Veeral M. Oza, Adam Hensel, Emile Daoud, Nishaki Mehta
  • Patent number: 10307521
    Abstract: A hands-free breast pump system is disclosed. A breast shield having an adhesive inner surface for adhering to a woman's breast is disclosed. The breast shield may be connected to an adapter for transferring a vacuum generated by a pump to the breast. The adapter also allows milk expressed from the breast to drain from the adapter to a container. In the alternative, the breast shield may form part of a breast shield adapter system which is connected to a conventional breast shield by a drain line so that a conventional breast pump system is used to supply a vacuum and to collect the milk.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: June 4, 2019
    Inventor: Lyndon Brittner
  • Patent number: 10307522
    Abstract: A blood purification apparatus is provided that allows setting work at the time of blood purification treatment or preparation for the treatment to be easily and smoothly performed.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: June 4, 2019
    Assignee: Nikkiso Company Limited
    Inventor: Hiroaki Mochizuki
  • Patent number: 10307523
    Abstract: In a blood purification device containing a blood purifier, a blood circuit, a blood pump, and a dialysate line having a fresh dialysate supply line and a used dialysate discharge line, a pair of plunger pumps are disposed in the dialysate line. The pair of plunger pumps are synchronized so that delivery of a fresh dialysate from one plunger pump and suction of a used dialysate into the other plunger pump simultaneously occur and the stroke of at least one of the pair of plunger pumps is made variable.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: June 4, 2019
    Assignee: Nipro Corporation
    Inventors: Mitsutaka Ueda, Tomoyuki Matsumoto, Shogo Okada, Hiroomi Nakano
  • Patent number: 10307524
    Abstract: A dialysis method includes: receiving at least one of blood pressure data from a blood pressure monitor or patient weight data from a weight scale at a dialysis machine at least one of (i) before or (ii) after each treatment performed by the dialysis machine; generating ultrafiltration (“UF”) removed data over a treatment performed by the dialysis machine; sending the UF removed data and at least one of the blood pressure data or the patient weight data to a server; determining at least one of a UF trend, a blood pressure trend or a patient weight trend from the UF removed data, the blood pressure data or the patient weight data, respectively; and displaying at least one of the UF trend, the blood pressure trend or the patient weight trend so that a therapy adjustment can be made if necessary.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: June 4, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Alex Anping Yu, James Grayson, Robert W. Childers
  • Patent number: 10307525
    Abstract: A contrast agent removing device configured to remove a contrast agent from blood vessels includes: an elongated outer tube 40; an inner tube 20 arranged in an interior of the outer tube 40; an expandable portion 30 interlocked with a distal portion of the inner tube 20 and configured to be capable of being stored within the outer tube 40 and to expand radially outward in a funnel shape opening in a distal direction by projecting from the outer tube in the distal direction; and a fixing portion 80 provided at the rim of the expandable portion 30 and configured to be capable of being fixed to a contact object.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: June 4, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Katsuhiko Shimizu, Keiko Yamashita, Hiroki Hosono, Yasukazu Sakamoto
  • Patent number: 10307526
    Abstract: A method and a device are disclosed for regulating an ultrafiltration in a dialysis treatment, in which the blood to be ultrafiltered in an extracorporeal blood circulation (109) flows through a blood chamber (110) of a dialyzer (113), which is subdivided by a semipermeable membrane (111) into a blood chamber (110) and a dialysis fluid chamber (108), and dialysis fluid in a dialysis fluid circulation (109) flows through the dialysis fluid chamber (108) of the dialyzer (113).
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: June 4, 2019
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Alexander Heide, Dejan Nikolic, Arne Peters, Christoph Wiktor
  • Patent number: 10307527
    Abstract: Systems, compositions, methods and kits employ protein shells, such as ferritin or viral capsid shells, herein called nanobubbles, to enhance X-ray images of cells or body tissue under certain x-ray imaging methods. The nanobubbles have sub-micron size such as about 10 nm, about 40, 60, or 100 nm and may be functionalized for effective delivery to or uptake by a target tissue, in vivo or a cell culture. The nanobubbles are hollow, having a central core which may be empty or contain a fluid, such that the shells effectively form long-lived bubbles in the imaged environment, and are of low electron density and have different scattering properties than the surrounding tissue. X-ray imaging by spatial frequency heterodyne imaging enhances visualization or detection of tissue regions bearing the shells. The protein shells may be further treated to assure biocompatibility and/or to resist undesired interactions with non-targeted tissue, such as scavenging by the liver, or attack by the immune system.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: June 4, 2019
    Assignees: Brown University, Montana State University
    Inventors: Christoph Rose-Petruck, Trevor Douglas, Danielle Rand, Masaki Uchida
  • Patent number: 10307528
    Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver fluid to a user in accordance with an operating mode involves identifying a fluid type associated with the fluid currently onboard the infusion device from among a plurality of possible fluid types that is different from a previous type of fluid previously onboard the infusion device. The identified fluid type has pharmacokinetics characteristics that are different from pharmacokinetics characteristics associated with the previous fluid type. The method continues by updating one or more parameters referenced by a control module of the infusion device implementing the operating mode to reflect the pharmacokinetics characteristics associated with the identified fluid type and autonomously operating the infusion device to deliver the fluid of the identified fluid type to the user in accordance with the operating mode and the one or more updated control parameters.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: June 4, 2019
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Belinda L. Lau, Mirsaid Seyed-Bolorforosh, Desmond Barry Keenan
  • Patent number: 10307529
    Abstract: A fluid delivery device comprises a drive unit including an actuator and one or more first features and a cartridge filled with a fluid prior to being inserted into the housing. The cartridge having a fluid reservoir sealed at one end by a movable piston and sealed at another end by a pierceable septum. The cartridge includes one or more second features that are configured to align and mate with the one or more first features allowing the cartridge to be inserted into the drive unit. The piston is moveable by the actuator once the cartridge is inserted into the drive unit.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: June 4, 2019
    Assignee: Valeritas, Inc.
    Inventor: Christopher C. Gregory
  • Patent number: 10307530
    Abstract: In various embodiments, approaches to calibrating an implantable drug-delivery device feature a drug reservoir, an expandable electrolysis chamber, and an integrated strain gauge using a refill apparatus having one or more pumps, one or more refill reservoirs, an outlet fluid channel fluidically connected to the refill reservoir(s), and a needle having a lumen in fluid communication with the outlet fluid channel include inserting a needle into a refill port of the implantable drug-delivery device, monitoring a pressure change within the device, monitoring a pressure level of one or more components of the implantable drug-delivery device, and calibrating the monitored pressure level of the component(s) of the implantable drug-delivery device to the monitored pressure level of the outlet fluid channel.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: June 4, 2019
    Assignee: MINIPUMPS, LLC
    Inventors: Jason Shih, Andrew Dunn
  • Patent number: 10307531
    Abstract: A device for receiving, without play, a syringe in a fluid-dispensing apparatus has at least two elastically prestressable clamps that grip the flange of the syringe plunger, and an elongated hole is provided for each clamp, such that during operation the clamp grips the plunger flange and slides in the elongated hole while simultaneously moving in a rotational and translatory manner.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: June 4, 2019
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Thomas Faulhaber, Thomas Weingaertner
  • Patent number: 10307532
    Abstract: A device for inserting an infusion cannula, or sensor, into a patient is presented. The device comprises an insertion needle removable within the infusion cannula, a handle connected to the insertion needle, and a needle cover. The needle cover pivotably mounted on the handle is rotatably movable between a first position, i.e., the front of the insertion needle is in the needle cover, and a second position, i.e., the front is exposed. An infusion site interface comprises a body mounted on a pad attached to the patient; an infusion cannula for inserting into the patient that is connected to the body; a cavity within the body fluidly connected to the cannula; and a septum that seals closed the cavity. The septum is penetrable by an insertion needle in the infusion cannula and by a hollow needle of an infusion tubing connector coupled to the infusion site interface.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: June 4, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Allen John Pearson, James Terence Collins, Neil Alexander Pryor
  • Patent number: 10307533
    Abstract: Medical fluid-flow regulating devices are provided. Such medical fluid-flow regulating devices typically include a rotor and a flow-regulator element engaged or engageable with each other via a coupling that below a torque and/or fluidic-pressure threshold value allows the flow-regulator element to move upon rotation of the rotor and thereby regulate fluid flow. The medical fluid-flow regulating devices also include a blocking unit that above the torque and/or fluidic-pressure threshold value irreversibly blocks the rotor or the flow-regulator element or the coupling between the rotor and the flow-regulator element resulting in irreversible inactivation of the medical fluid-flow regulating device. Systems incorporating such medical fluid-flow regulating devices are also provided. Methods for detecting inactivation of such devices are also provided.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: June 4, 2019
    Assignee: Medirio S.A.
    Inventors: Irio Giuseppe Calasso, Einar Petersen, Tobias Von Cappelen, Klaus Dietrich, Matteo De Donatis
  • Patent number: 10307534
    Abstract: An infusion set includes a first infusion line set that forms a first infusion line with an injection port; and a connector including a male connector end that is insertable into the injection port, a female connector end to which a second infusion line can be connected, a flow channel, and a partition. The injection port and the connector are configured such that, when the male connector end of the connector is inserted into the injection port, the flow channel of the connector is divided by the partition into an in-flow channel configured to let in a liquid from the injection port in the first infusion line and an out-flow channel configured to let out the liquid that has entered the in-flow channel to the injection port.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: June 4, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Kazuya Akiyama
  • Patent number: 10307535
    Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of alerting a user associated with an infusion device delivering fluid to the body of the user involves obtaining a measurement value for a physiological condition being influenced by the fluid, obtaining a current amount of active fluid in the body of the user, determining a homeostasis metric based at least in part on the current amount of active fluid and the measurement value for the physiological condition, and generating an alert based at least in part on the homeostasis metric.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: June 4, 2019
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Cesar C. Palerm, Jeffrey C. Myers
  • Patent number: 10307536
    Abstract: Some embodiments of a medical infusion pump system include a pump device having a cap device that mates with a pump housing to retain a medicine cartridge therein. In addition to retaining the medicine cartridge in the pump housing, the cap device may perform a number of preparatory functions or safety functions. In addition or in the alternative, some embodiments of the pump device may include a drive system that advances a piston rod to dispense medicine to the patient in a safe and energy efficient manner.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: June 4, 2019
    Assignee: Bigfoot Biomedical, Inc.
    Inventors: James Causey, Todd Kirschen, Mitchell Wenger, Steven A. Friedman, Joshua Colton, Keld Sloth Christensen
  • Patent number: 10307537
    Abstract: A liquid detection system for detecting a liquid level position of a liquid in a hanging bottle includes a hanging bottle casing unit for determining the overall gravity of the hanging bottle, a hanging bottle cap unit for determining the liquid density in the hanging bottle, and a transmission unit for transmitting the overall gravity and liquid density of the hanging bottle to a server, and the server. The server is configured to determine the liquid gravity in the hanging bottle, calculate the liquid volume in the hanging bottle based on the liquid gravity and the liquid density, and determine a liquid level position based on the liquid volume.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: June 4, 2019
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventor: Chuang Wei
  • Patent number: 10307538
    Abstract: A method may include generating a first plurality of insulin delivery profiles that include a first series of insulin delivery actions spanning a first time interval, projecting a first plurality of future blood glucose values for each profile of the first plurality of profiles using up-to-date blood glucose levels, selecting one of the first plurality of profiles based upon comparing future blood glucose values for each profile and target blood glucose levels, delivering insulin for a second time interval that corresponds to a first action of the first profile, generating a second plurality of insulin delivery profiles for a third time interval, projecting a second plurality of future blood glucose values for each profile of the second plurality of profiles for the third time interval, and delivering a second dose of insulin for a fourth time interval shorter than the third time interval.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: June 4, 2019
    Assignee: Bigfoot Biomedical, Inc.
    Inventors: Lane Desborough, Bryan Mazlish
  • Patent number: 10307539
    Abstract: A medicament delivery device includes a generally elongated tubular housing having opposite proximal and distal parts; a needle shield sleeve slidably and coaxially arranged inside the housing with a proximal part of the sleeve protruding a distance outside the proximal part of the housing; a syringe carrier mechanism having a syringe carrier slidably and coaxially arranged within the needle shield sleeve, a syringe having a stopper, a medicament, and a needle, the syringe being coaxially arranged within the syringe carrier; and a holding member connected to the syringe carrier; a first activator member an a second activator member; a drive mechanism adapted to accumulate a drive force for moving the syringe carrier mechanism in a first step and a second step. The second activator member is arranged within an information device for producing audible, visual, and/or tactile feedback to a user about a completed injection.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: June 4, 2019
    Assignee: SHL Medical AG
    Inventor: Oscar Alexandersson
  • Patent number: 10307540
    Abstract: The present application relates to a needleless syringe for injecting an injection objective substance into an injection target area without using an injection needle. In one aspect, the needleless syringe includes a main syringe body containing the injection objective substance with the use of a sealing member, a pressurizing unit provided in the main syringe body and configured to pressurize the injection objective substance, a flow passage unit defining a flow passage of the pressurized injection objective substance to be discharged to the injection target area and a preparatory filling unit configured to fill the flow passage unit with a part of the injection objective substance by destroying a part of the sealing member before the injection objective substance is pressurized. According to some embodiments, it is possible to mitigate the load exerted on the nozzle during the injection and reduce the noise without deteriorating a syringe user convenience.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: June 4, 2019
    Assignee: Daicel Corporation
    Inventors: Masahiro Haitsuka, Masayuki Ueda
  • Patent number: 10307541
    Abstract: A drive mechanism of a drug delivery device for dispensing of a dose of a medicament includes a housing extending in an axial direction, and a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction. The drive mechanism further includes a last dose sleeve rotatably supported in the housing and being selectively engageable with a dose setting mechanism for setting of a dose, and a last dose member threadedly engaged to the housing, rotatably locked to the last dose sleeve and axially displaceable relative to the last dose sleeve.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: June 4, 2019
    Assignee: Sanofi
    Inventors: Stefan Bayer, Daniel Berning, Philippe Blank, Wolfgang Pelzer, Björn Wilden
  • Patent number: 10307542
    Abstract: According to one embodiment, a handle includes a frame and a connection surface coupled to the frame. The connection surface is configured to grasp a rotary dial of a medicinal pen. The handle further includes a cap rotatingly coupled to the frame. The cap is configured to rotate with respect to the frame.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: June 4, 2019
    Inventor: David I. Levenson
  • Patent number: 10307543
    Abstract: A power pack assembly for a medicament delivery device, the power pack comprising a plunger rod (64) extending along a longitudinal axis (L) and having a proximal and an opposite distal ends, an actuator (90) provided with a holding element (96) and configured to interact with a corresponding holding element on the plunger rod (64), a first force element (68) arranged to exert a force on the plunger rod; an actuator sleeve mechanism (119) arranged to releasably lock said holding element (96) in engagement with the corresponding holding element of said plunger rod (64) such as to hold said first force element (68) in a tensioned state.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: June 4, 2019
    Assignee: SHL Medical AG
    Inventors: Hsueh-Yi Chen, Jung-Chien Chou, Jyun-An Yao
  • Patent number: 10307544
    Abstract: The disclosure is directed to a differential gear mechanism for a drug delivery device with a primary drug delivery assembly and a secondary drug delivery assembly, wherein the primary drug delivery assembly comprises a primary dose dial sleeve and wherein the secondary drug delivery assembly comprises a secondary drive sleeve. The disclosure is also directed to a respective drug delivery device.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: June 4, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Matthew Meredith Jones, Samuel Keir Steel, Neal Alexander Blundred, Joseph Butler, Robert Frederick Veasey, David Plumptre, Anthony Paul Morris
  • Patent number: 10307545
    Abstract: A cap assembly for a medicament delivery device is disclosed. The cap assembly includes a cap configured to be mounted to a proximal end of the medicament delivery device, wherein the cap comprises a cam surface. The cap assembly further includes a squeezer comprising (i) a body defining a first longitudinally extending channel configured to receive a delivery member shield and (ii) a plurality of radial arms flexible in a radial direction. The cap assembly also includes a spinner comprising (i) a proximal end face configured to cooperate with the cam surface of the cap, (ii) a body defining a second longitudinally extending channel configured to receive the squeezer, and (iii) a plurality of holes in the body of the spinner configured to receive the plurality of radial arms of the squeezer.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: June 4, 2019
    Assignee: SHL Medical AG
    Inventor: Brian Maxfield
  • Patent number: 10307546
    Abstract: The present invention involves a sterilizable syringe allows for reduction in needlestick injuries using conventional sterile needles. The syringe allows for direct access to and the safe removal and disposal of needles. The device consists of a sterilizable, reusable hypodermic syringe to which a disposable needle is attached, and employs carpules containing injectable medication, viewable and either manually or automatically aspirating. Some embodiments have a protective sliding mechanism consisting of an open frame bearing one or more protective collars, one at the furthermost end of the frame and an optional second one at a more proximal position. The protective mechanism may be extended to protect an exposed needle tip and retracted during an injection. With the protective mechanism extended, the needle mounting hub is exposed to allow for its exchange or removal and safe disposal.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: June 4, 2019
    Assignee: ULTIMATE SYRINGETEK INC.
    Inventor: Melvyn Lloyd Sawyer