Patents Issued in June 4, 2019
  • Patent number: 10307547
    Abstract: Syringe assemblies having a passive disabling system to prevent reuse are provided. According to one or more embodiments, the syringe assembly comprises a barrel, plunger rod and detachable thumb press wherein the plunger rod further comprises flexible locking petals that lock the plunger rod within the barrel, a ramp disposed adjacent to the locking element, and one or more frangible connection or break point at the proximal end of the plunger rod disposed either inside the thumb press or immediately adjacent to the thumb press to separate the thumb press from the main body of the plunger rod when a user applies sufficient proximal force to the plunger rod after it has been locked within the barrel.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: June 4, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Yan Yevmenenko, Andrew Wong
  • Patent number: 10307548
    Abstract: A tracking system for medical devices which may include a closure and a container and a method for implementation the tracking system. Packaging removably retains the closure therein and a label is connected to the closure in an at least initially reduced orientation within the packaging. The packaging is structured for receipt of at least a portion of the container to establish an attached relation to the closure, whereupon the attached closure and container are concurrently removed from the packaging. The label is disposed in an expanded orientation and connected to both the closure and the container and includes a coded identifier having at least first and second coded segments. The coded identifier, including the first and second coded segments, include coded indicia may be machine readable and structured to define an identifying, matching relation of the closure and the container.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: June 4, 2019
    Inventors: Timothy Brandon Hunt, Jonathan J. Vitello
  • Patent number: 10307549
    Abstract: An aerosol generating device (20) comprises a reservoir (1) for containing a liquid to be atomized and a nebulization chamber (3) for nebulizing a portion of the liquid received from the reservoir. The aerosol device further comprises liquid exchange means (7,8) for exchanging in use a further portion of the liquid received in the nebulization chamber with liquid from the reservoir to reduce a temperature increase of liquid in the nebulization chamber caused by heat produced by the piezo (4).
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: June 4, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Petrus Henricus Cornelius Bentvelsen, Hendrik Huijgen
  • Patent number: 10307550
    Abstract: Liquid drug cartridges and an associated inhaler are used to deliver one more separate doses of an aerosolized liquid drug. A cartridge includes a container for storing the liquid drug, an end cap having an ejection opening, a filter element, and a piston that is repositionable relative to the container to selectively eject a volume of liquid drug from the ejection opening. The filter element filters the liquid drug prior to ejection from the ejection opening. The liquid drug cartridge can be coupled with an inhaler that includes an aerosol generator. The aerosol generator includes a vibratable membrane onto which the liquid drug is ejected. The liquid drug is aerosolized by the vibration of the membrane for inhalation by a user.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: June 4, 2019
    Assignee: Dance Biopharm Inc.
    Inventors: Benjamin Stedman, Jim Fink, Lisa Molloy, Matt Sander
  • Patent number: 10307551
    Abstract: An inhaler is provided that includes a controller, a driver, an atomizer and one or more sensors for detecting information about a velocity of inhalation of a user of the inhaler. The controller is configured to dispense an inhalant from the inhaler during an inhalation of the user based on information about the velocity of inhalation of the user. Such information can include a duration of maximum inhalation velocity or an increase or maximum in the acceleration in inhalation velocity. Embodiments of the inhaler can be used to enhance the delivery of drugs and therapeutic agents for those patients having a weakened respiratory system who are unable to take a deep or full breadth, e.g., patients having asthma or COPD. Embodiments of the inhaler can be used to deliver a variety of drugs and therapeutic agents including agents for the treatment of asthma, diabetes, epilepsy and heart disease.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: June 4, 2019
    Assignee: InCube Labs, LLC
    Inventor: Mir Imran
  • Patent number: 10307552
    Abstract: An adaptor comprises comprising a base element and a nozzle element which are operatively coupled to each other. The base element defines a throat and at least one entrainment port facilitating a path of fluid communication between the throat and ambient air. The nozzle element includes a jet nozzle, and a connector which is adapted to facilitate the fluid coupling of the nozzle element to a bi-lumen tube of the patient circuit. The connector includes both a delivery port and a sensing port. The jet nozzle and the delivery port collectively define a delivery line or lumen which fluidly communicates with the throat of the base element, and is placeable into fluid communication with the delivery lumen of the bi-lumen tube.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: June 4, 2019
    Assignee: Breathe Technologies, Inc.
    Inventors: Enrico Bambrilla, Samir S. Ahmad
  • Patent number: 10307553
    Abstract: An nCPAP device for assisting patient breathing includes a generator body forming an inlet, a chamber, and first and second flow circuits. The chamber directs pressurized gas from the inlet to the flow circuits. The flow circuits each include a nozzle, a channel, and at least one port. The nozzle emits a jet stream into the channel in a direction of a patient side thereof. The port fluidly connects the channel to ambient, and promotes entrainment of ambient air with the jet stream. In some embodiments, the channel forms a ramp feature directing exhaled air toward the jet stream in an angular fashion. The generator body requires reduced driving pressures to achieve target CPAP levels and reduces total imposed WOB as compared to conventional designs.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: June 4, 2019
    Assignee: CAREFUSION 207, INC.
    Inventors: Christopher M. Varga, Geoffrey C. Wise
  • Patent number: 10307554
    Abstract: A comfortable low-leak mask assembly for use with Non-Invasive Positive Pressure Ventilation (NIPPV) is provided to improve patient compliance and/or treatment. The mask system may include headgear having straps that are substantially inextensible and/or micro-adjustable; and/or a mask and/or cushion that includes various structures to allow enhanced/tailored sealing and/or fit at selected locations on the patient's face.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: June 4, 2019
    Assignee: ResMed Limited
    Inventors: Michael Berthon-Jones, Peter Edward Bateman, Donald Darkin, Robin Garth Hitchcock, Philip James Jenkinson, Susan Robyn Lynch, Gordon Joseph Malouf, Patrick John McAuliffe, Milind Chandrakant Raje, Gary Christopher Robinson, Richard Sokolov, Philip Thomas Stallard, Michael Kassipillai Gunaratnam
  • Patent number: 10307555
    Abstract: A patient interface has a frame with an opening to receive pressurized gas; a cushion permanently co-molded to frame and defining a breathing chamber; an elbow assembly releasably snap-fittable to the frame with an audible click signaling secure attachment between the elbow assembly and the frame, the elbow assembly including a rotatable swivel elbow; headgear to support the patient interface on the patient's head; and a plurality of gas washout holes to allow escape of CO2 from the breathing chamber.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: June 4, 2019
    Assignee: ResMed Pty Ltd
    Inventors: Anthony Michael Ging, Philip Rodney Kwok, Rachael Elizabeth Moore, Saad Nasr, Andrew Martin Price
  • Patent number: 10307556
    Abstract: Patient interface devices (8) structured to deliver a flow of breathing gas to an airway of a patient include a member (16) structured to contact and adhere to a face of the patient responsive to the patient interface being donned by the patient, the member having a contact surface and an adhesive layer (34) provided on the contact surface.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: June 4, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Antonio Bugamelli, Jerome Matula, Jr., Lutz Christian Gerhardt, Steven Ernest Franklin, Harmina Christina Zeijlstra, Lance Ranard Busch
  • Patent number: 10307557
    Abstract: A tracheal tube assembly includes an outer cannula configured to be positioned in a patient airway and an inner cannula configured to be disposed inside the outer cannula. The tracheal tube assembly further includes a flange member secured about the outer cannula, and an outer cannula connector coupled to a proximal end of the outer cannula. The outer cannula connector includes a compressible portion may be compressed while inserting or removing the inner cannula.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: June 4, 2019
    Assignee: COVIDIEN LP
    Inventors: Martin J. Bruggemann, James M. Ryan, Declan Kiernan, Alan Finneran, Seamus P. Maguire
  • Patent number: 10307558
    Abstract: A gas-flow indicator has an elongate housing defining a gas flow chamber between first and second ends, with an annular indicator within the chamber from the first end over part of the length enabling gas to pass along a bore through the indicator. The indicator is spaced from a sidewall of the housing, defining an annular space. A concealment member is movable from the first end by gas flow through the chamber, against a biasing towards the first end and has a skirt receivable into the space to seal at the first end, while the other end of the concealment member defines an opening resisting gas flow. The skirt is hold-able to conceal the indicator at a housing window. Increasing gas flow achieves pressure to overcome the bias, and the concealment member moves towards the second end, exposing the indicator member through the window, to indicate gas flow.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: June 4, 2019
    Assignee: VPAS Group Pty Ltd
    Inventor: Matthew Matusik
  • Patent number: 10307559
    Abstract: A humidifier includes a heating element including a porous structure of electrically resistive and thermally conductive material configured to substantially vaporise liquid that is passed through the porous structure. The porous structure has a liquid inlet and a vapour outlet. The humidifier further includes an outer housing surrounding at least a portion of the porous structure for containing the liquid and vapour within the porous structure. The porous structure includes a first electrical connector and a second electrical connector, the first and second connectors being configured for receiving electrical power and applying a voltage across the porous structure to generate heat.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: June 4, 2019
    Assignee: ResMed Limited
    Inventors: Roger Mervyn Lloyd Foote, Ronald James Huby, Andrew Roderick Bath
  • Patent number: 10307560
    Abstract: A positive airway pressure (PAP) device for supplying a flow of breathable gas to a patient includes a flow generator configured to pressurize a flow of breathable gas and a humidifier configured to receive and humidify the pressurized flow of breathable gas from the flow generator. The PAP device also includes a power source. The flow generator, humidifier and power source are positioned so that heat generated by at least one of the flow generator and the power source is conveyed to water in the humidifier.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: June 4, 2019
    Assignee: ResMed Limited
    Inventors: Dion Charles Chewe Martin, Barton John Kenyon, Alexander Virr, Dmitri Anatolievich Doudkine, Philip Rodney Kwok, Richard Charles Napper, John Michael Snow
  • Patent number: 10307561
    Abstract: A vent arrangement for a respiratory pressure therapy device may include one or a plurality of vents configured with a variable aperture for communicating a flow of breathable gas. The vent arrangement may be configured with a cross section profile exposed to the flow of breathable gas communicating through the vent that does not change as the aperture size changes. A vent arrangement may include a plurality of the vents and the aperture size of each vent may be controlled independently or together, and may be controlled according to one or more input signals from one or more sensors. Examples of suitable input signals include flow, pressure, noise, accelerometer outputs, orientation of a patient or presence of any obstructions. A patient interface or an air circuit may include the vent arrangement, or the vent arrangement may be configured to connect with a patient interface or an air circuit.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 4, 2019
    Assignee: ResMed Limited
    Inventor: Roger Mervyn Lloyd Foote
  • Patent number: 10307562
    Abstract: A device for treating a patient suffering from obstructive sleep apnea or snoring can include an expiratory valve connected to a manifold. The expiratory valve can include a body portion including a feedback port configured to be connected to an air flow generator. The expiratory valve can include a plunger at least partially disposed in the body portion. The expiratory valve can include a pressurizing chamber positioned between an end of the plunger and an end of the expiratory valve. The pressurizing chamber can be configured to receive air from the air flow generator through the feedback port.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: June 4, 2019
    Assignee: FRESCA Medical, Inc.
    Inventors: Andrew H. Cragg, John Logan, Haim Nissimov, Richard Christian Ewers, Mark Alan Adler, Eugene G. Chen, John Edwin Trusheim, John Eugene Nolting, Stephen William Anderson, Kevin Nai Hong Chen
  • Patent number: 10307563
    Abstract: A sleep enhancement device for toddlers and young children, including: a containment assembly and an electronics assembly, wherein both assemblies cooperatively create the psychological appearance that the device is at least one of catching and destroying monsters and/or bad dreams, and provides a soothing, relaxing, deep, and/or healthy sleep.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 4, 2019
    Inventor: Dustin Kooyers
  • Patent number: 10307564
    Abstract: Ureteral catheters and assemblies are provided including: a drainage lumen including a proximal portion configured to be positioned in at least a portion of a patient's urethra and a distal portion configured to be positioned in a patient's ureter and/or kidney, the distal portion including a coiled retention portion including at least a first coil having a first diameter and a second coil having a second diameter, the first diameter being less than the second diameter; or wherein the retention portion extends radially outwardly from a portion of the distal end of the drainage lumen portion, the retention portion including a proximal end having a first diameter, a distal end having a second diameter, and a wall and/or surface extending therebetween, the retention portion having a second diameter is greater than the first diameter when deployed; or wherein the retention portion includes a plurality of drainage tubes.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: June 4, 2019
    Assignee: Strataca Systems Limited
    Inventors: John R. Erbey, II, Jacob L. Upperco, Michael Allen Fisher, Patrick William Strane, Lance Michael Black
  • Patent number: 10307565
    Abstract: An accommodation tool is disclosed with which an operator can easily wind and accommodate a flexible medical elongated body. An accommodation tool winds and accommodates the flexible medical elongated body, for example, a guide wire. The accommodation tool has an inner wall, an outer wall, and an interlock wall. The guide wire is wound around the inner wall. The outer wall defines an accommodation space for accommodating the guide wire between the inner wall and the outer wall, and that is disposed further outward in a radial direction from a centroid of the accommodation tool than the inner wall. The interlock wall interlocks one end portion of the inner wall and one end portion of the outer wall with each other.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: June 4, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yuuki Sakaguchi, Yushin Yazaki, Jo Fujiki, Takito Inukai
  • Patent number: 10307566
    Abstract: A drainage or infusion catheter and methods of use are disclosed. In one embodiment, the catheter includes a tube body having a proximal end and a distal end, and a plurality of ports arranged along the tube body from the distal end to the proximal end. The distal end of the tube body is configured to deform around itself into a substantially spiral shape so as to cover at least one of the plurality of ports located near the proximal end of the tube body. In another embodiment, a flap is configured to erupt from apertures arranged in the tube and extend outwardly around the tube body so as to cover at least one of the plurality of ports located near the proximal end of the tube body.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: June 4, 2019
    Assignee: DUKE UNIVERSITY
    Inventor: Muath Bishawi
  • Patent number: 10307567
    Abstract: Catheters are disclosed that are configured for insertion into the vasculature connected to the prostate gland of a male patient or uterus of a female patient. Such catheters may comprise a conduit having one or more bends. Conduits with a general U-shaped bend and a compound curve are within the scope of this disclosure Methods related to the catheters, including methods of use and methods of manufacture, are also disclosed.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: June 4, 2019
    Inventor: Francisco Cesar Carnevale
  • Patent number: 10307568
    Abstract: A stiffenable structure is made of longitudinal beams that are positioned around a longitudinal axis. In one state, the longitudinal beams are bendable so that the structure is bendable. As the structure bends, the longitudinal beams slide longitudinally with reference to one another. In a second state, the beams are clamped in a fixed position relative to one another so that the structure is stiffened. In some aspects the longitudinal beams are made of two or more longitudinal laminar elements. As each beam bends, the laminar elements slide longitudinally with reference to one another. Each beam, and accordingly the structure, is stiffened by preventing the laminar elements from sliding longitudinally relative to one another.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: June 4, 2019
    Assignee: INTUITIVE SURGICAL OPERATIONS, INC.
    Inventor: Theodore W. Rogers
  • Patent number: 10307569
    Abstract: Systems, devices, and methods are provided for transseptal access of septa within a patient. The device can be advanced to a septum, e.g., towards a fossa ovalis. Instead of applying positive pressure to “tent” the septum, a negative pressure is applied to a lumen within a sheath, e.g., within an elongated member slidable within the sheath, via a negative pressure source such as a syringe on the proximal end of the sheath. This results in the septum pulling inward. The sheath employs a stationary needle-like central core component contained within the lumen of the sheath that punctures the septum when the same is pulled passed it by the negative pressure. The stationary needle-like central core component may be hollow and may form a portion of the elongated member or may be coupled to a distal end thereof.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: June 4, 2019
    Inventor: Christopher Gerard Kunis
  • Patent number: 10307570
    Abstract: An extension member is has a body with a proximal end and an opposing distal end. It includes a hollow lumen extending therethrough from the proximal end to the distal end. It has a female luer lock connector proximate its proximal end and a male luer lock connector proximate its distal end. Its body has an outeHr surface with a driven member.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: June 4, 2019
    Assignee: CORINDUS, INC.
    Inventor: Steven J. Blacker
  • Patent number: 10307571
    Abstract: A bi-directional cannula feature capture mechanism is described herein. Generally, the capture mechanism comprises an inner housing, an outer housing, and a cannula. The inner housing comprises a proximal and a distal cannula feature mating component. The outer housing is adapted to slidably receive the inner housing in a proximal direction. Additionally, the cannula extends through the inner housing and the cannula's feature has a proximal engagement and a distal engagement. The proximal and distal engagements are respectively configured to irreversibly engage the proximal and distal cannula feature mating components when the cannula tip is moved into a shielded position.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: June 4, 2019
    Assignee: Becton, Dickinson and Company
    Inventor: Jonathan Karl Burkholz
  • Patent number: 10307572
    Abstract: The invention relates to a needle safety device for a medical device, the needle safety device comprising: a base portion having a bore extending along a longitudinal center axis therethrough for receiving a needle; and two opposing jaws extending from the base portion generally in the axial direction and each having a head portion in the region of its free end, wherein the needle safety device includes a locking projection for securing the needle safety device to the medical device. The needle safety device according to the invention further provides at least one elastic element mounted to the jaws in a non-surrounding manner lateral to the center axis in a region between the base portion and the head portions, wherein at least one elastic element and the jaws are configured such that the jaws can be spread apart against a restoring force of at least one elastic element in order to allow the needle received in the bore to extend all the way through the needle safety device.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: June 4, 2019
    Assignee: POLY MEDICURE LIMITED
    Inventor: Rishi Baid
  • Patent number: 10307573
    Abstract: A balloon catheter having an elongated catheter shaft defining a fluid drainage lumen and a balloon inflation lumen. The balloon catheter includes a fluid drainage port disposed about the distal end of the catheter shaft in fluid communication with the fluid drainage lumen, and a balloon inflation port disposed about the distal end of the catheter shaft in fluid communication with the balloon inflation lumen. A balloon portion is disposed about the distal end of the catheter shaft in fluid communication with the balloon inflation port. A release device is disposed in fluid communication with the balloon portion and the fluid drainage lumen, and includes an activating member. A tether is attached to the activating member of the release device. Tension applied to the tether activates the release device, enabling fluid flow from the balloon portion into the fluid drainage lumen and out of the body.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: June 4, 2019
    Assignee: Sanford Health
    Inventors: Bruce A. Gardner, Jeffery A. Gardner, David Allan Swanson
  • Patent number: 10307574
    Abstract: Surgical drains and methods for using the same for draining a body cavity are provided. Aspects of the surgical drains of the invention include an elongated structure having a proximal end and a distal end and a lumen configured to drain a substance from the body cavity. The distal end is configured to be placed in a body cavity and change in diameter when present in the body cavity from a first diameter to a second diameter that is smaller than the first diameter, where the change in diameter is mediated by a diameter-varying element. Aspects of the invention further include sheaths configured to be disposed around surgical drains, such as surgical drains of the invention, and methods of using the surgical drains and sheaths. The devices and methods of the invention find use in a variety of applications.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: June 4, 2019
    Inventor: John R. Dein
  • Patent number: 10307575
    Abstract: The procedure to place antegrade hemodynamic support (AHS) combine currently available procedures and devices in a unique fashion to solve a significant problem for patients who need large bore hemodynamic support. The AHS procedure involves delivering an AHS device or a catheter connected to an AHS device to a patient's aorta in an antegrade fashion, alleviating the workload on the patient's heart and supporting the patient hemodynamically to maintain normal functions of the body organs.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: June 4, 2019
    Assignee: Henry Ford Health System
    Inventor: Khaldoon Alaswad
  • Patent number: 10307576
    Abstract: Methods for treating hydrocephalus using a shunt, the shunt having one or more CSF intake openings in a distal portion, a valve disposed in a proximal portion of the shunt, and a lumen extending between the one or more CSF intake openings and the valve, the method comprises deploying the shunt in a body of a patient so that the distal portion of the shunt is at least partially disposed within a CP angle cistern, a body of the shunt is at least partially disposed within an IPS of the patient, and the proximal portion of the shunt is at least partially disposed within or proximate to a JV of the patient, wherein, after deployment of the shunt, CSF flows from the CP angle cistern to the JV via the shunt lumen at a flow rate in a range of 5 ml per hour to 15 ml per hour.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: June 4, 2019
    Assignee: CEREVASC, LLC
    Inventors: Carl Heilman, Adel M. Malek, David A. Rezac, Timothy W. Robinson, Joseph Ting
  • Patent number: 10307577
    Abstract: Systems and methods for implanting an endovascular shunt in a patient is disclosed. The system having an expandable anchor configured for being deployed in a dural venous sinus of a patient at a location distal to a curved portion of a wall of an inferior petrosal sinus (IPS) of the patient; an elongate guide member coupled to, and extending proximally from, the anchor; a shunt delivery catheter having a first lumen configured to receive the guide member, and a second lumen extending between respective proximal and distal openings in the shunt delivery catheter, the shunt delivery catheter further having a penetrating element coupled to a distal end of the catheter; and the system further having a guard at least partially disposed over, and movable relative to, the penetrating element.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: June 4, 2019
    Assignee: CEREVASC, LLC
    Inventors: Adel M. Malek, Carl Heilman, David A. Rezac, Jack B. Sattell, Anthony Maiorano
  • Patent number: 10307578
    Abstract: A microneedle array cartridge includes a web of material having a top face and an opposite bottom face. An adhesive and a microneedle array are disposed on the bottom face of the web of material. A container is disposed relative to the bottom face of the web of material, and has a perimeter portion and a central portion for covering at least part of the microneedle array. At least part of the perimeter portion of the container contacts the adhesive, and the central portion of the container does not contact the adhesive. The perimeter portion and the central portion of the container are integrally formed.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: June 4, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Franklyn L. Frederickson, Michael D. Johnson
  • Patent number: 10307579
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: June 4, 2019
    Assignee: Rani Therapeutics, LLC
    Inventor: Mir Imran
  • Patent number: 10307580
    Abstract: The present disclosure generally relates to methods, devices and systems relating to applying drugs or therapeutic agents to biological conduits, e.g., vascular lumens. More specifically, the present invention comprises enhancing the uptake of drugs or therapeutic agents encapsulated in microbubbles in combination with ultrasound energy as well as applying drugs or therapeutic agents in a cyclic manner using a pulse generator that may be matched in frequency with a patient's blood pulsing.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: June 4, 2019
    Assignee: Cardiovascular Systems, Inc.
    Inventors: Victor L. Schoenle, Matthew D. Cambronne, Brittany N. Pusey, Jeffrey A. McBroom
  • Patent number: 10307581
    Abstract: A septum for sealably covering a fluid cavity defined in an implantable device, which may be an access port, and methods for assembling the implantable device. The septum may include a resilient septum body, an annular flange extending radially outward from the septum body, and a reinforcement component disposed in the annular flange for reinforcing engagement with a corresponding annular groove defined in a body of the implantable device. The reinforcement component may inhibit unintended detachment of the septum from the implantable device.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: June 4, 2019
    Assignee: C. R. Bard, Inc.
    Inventors: Dwight T. Hibdon, Kelly J. Christian, Charles L. Farnworth
  • Patent number: 10307582
    Abstract: Fluid flow conduits and apparatus and methods for joining the conduits, preferably in a sterile manner, are disclosed. Each conduit has a polymeric open end that is sealed by a sealing member that may include a heating element. The polymeric end material is melted, the sealing members are moved to expose the melted open ends of the conduits and the ends are brought together to form a fused or welded connection between the conduits.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: June 4, 2019
    Assignee: Fenwal, Inc.
    Inventors: Christopher Wegener, Kyungyoon Min, Mark Brierton, Benjamin Kusters, James Madsen, William H. Cork
  • Patent number: 10307583
    Abstract: An aseptic coupling arrangement includes a first coupling device and a second aseptic coupling device. In one example, the first and second coupling devices are substantially similar, each having a main body having a front face and a fluid passageway therethrough. A first connecting feature on the main body of each coupling device may be provided for aligning and coupling the aseptic devices together. Each coupling device may also include a sealing member received in the main body and a membrane removably coupled to the main body front face to cover the sealing member. The first aseptic coupling device may also include a rotatable protective cover that is removably attached to the main body and connected to the membrane. In one example, the removal of the protective covers away from two coupled main bodies, in a direction parallel to the front faces, causes removal of the membranes.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: June 4, 2019
    Assignee: Colder Products Company
    Inventors: Randall Williams, Loi Truong, Blair Plackner, Jeremy Henry Nichols
  • Patent number: 10307584
    Abstract: A breaker device for acting onto a closure element (40) of a medical tubing (4) comprises: a drive arrangement (2) having a drive device (20), a drive element (23) driven by the drive device (20) and at least one locking element (22A, 22B), and a breaker module (3) which is arrangeable on the drive arrangement (2). The breaker module (3) comprises a housing (30), a movable part (31) movably arranged on the housing (30), a breaking element (315) for acting onto the closure element (40) of the tubing (4) and a locking mechanism (32A, 32B). The breaker module (3) in an attached state is placed on the drive arrangement (2) and is locked to the drive arrangement (2) via the locking mechanism (32A, 32B) engaging with the at least one locking element (22A, 22B), the drive element (23) being in operative connection with the movable part (31) in the attached state such that a movement of the drive element (23) causes the movable part (31) to move for actuating the breaking element (315).
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: June 4, 2019
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Thomas Brückner, Christian Hennecke, Safet Jukovic
  • Patent number: 10307585
    Abstract: Systems and methods are provided for applying electrical stimulation to a body by an electrode spaced from a target nerve of passage. It has been discovered that pain felt, or perceived to be felt, in a given region of the body can be treated by stimulating muscle close to a “nerve of passage” in a region that is superior (i.e., cranial or upstream toward the spinal column) to the region where pain is felt, such as in a case of post-amputation residual limb pain, or purportedly felt in the case of post-amputation phantom limb pain.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: June 4, 2019
    Assignee: SPR THERAPEUTICS, INC.
    Inventors: Joseph W. Boggs, Rosemary H. Zang
  • Patent number: 10307586
    Abstract: A system and method for relieving high blood sugar factor of diabetes includes an energy wave generator with an energy wave's frequency control mode. The energy wave's frequency control mode includes multiple controls for controlling and generating energy waves with corresponding energy densities to effect on diabetic patient's body, so as to reduce and eliminate the high blood sugar factors of the diabetic patient.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: June 4, 2019
    Assignee: Taiwan Resonant Waves Research Corp.
    Inventor: Wen-Chieh Chang
  • Patent number: 10307587
    Abstract: An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: June 4, 2019
    Assignee: VOMARIS INNOVATIONS, INC.
    Inventors: Wendell King, Mary Maijer, Amy Ho, Alex Read, Jeffry Skiba, Michael Nagel
  • Patent number: 10307588
    Abstract: The invention entails metal alloy mono and poly-filament wire reinforced carbon fiber plating system for the fixation of skeletal fractures and osteotomies with electrical bone stimulation. For example, in some embodiments, systems and methods comprise a bone stimulation device by generating an electrical current from an implanted power pack, which travels through wire wrapped in the transverse/perpendicular plane around the mono-poly filament wires within the carbon fiber plate, creating an electromagnetic field. Such systems and methods find use in delayed or non-union events of bone and also in patients with acute bone fractures whom also suffer from other comorbidities predisposing the osteotomy or fracture to a non-union event.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: June 4, 2019
    Assignee: ELEMENTAL ORTHOPEDICS LLC
    Inventor: Jordan Tacktill
  • Patent number: 10307589
    Abstract: The present invention is a system and method for providing an electrical stimulation signal to condition the pelvic wall muscles of a user and demonstrate to the user the proper muscle usage. The system and method also provides a system for measuring the users muscle response. The system and method also provides an entertaining interaction environment which encourages the user to perform self-initiated conditioning exercises.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: June 4, 2019
    Inventor: Brent C. Reider
  • Patent number: 10307591
    Abstract: A topical nerve stimulator patch and system are provided comprising a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: June 4, 2019
    Assignee: NEUROSTIM SOLUTIONS, LLC
    Inventors: Graham H. Creasey, Hoo-Min Toong
  • Patent number: 10307592
    Abstract: Described is a system for consolidation of specific memories of events. A sleep state detector assesses a subject's sleep state from neural recordings obtained from a high-density electroencephalogram (HD-EEG) device. During a memory encoding phase, a high-definition transcranial current stimulation (HD-tCS) system simultaneously applies a spatiotemporal amplitude-modulated pattern (STAMP) tag and a transcranial direct current stimulation (tDCS) signal to the subject as an event is experienced by the subject. During a memory consolidation phase, the HD-tCS system applies a transcranial alternating current stimulation (tACS) signal to the subject during a sleep or quiet waking state of the subject.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: June 4, 2019
    Assignee: HRL Laboratories, LLC
    Inventors: Praveen K. Pilly, Michael D. Howard, Jaehoon Choe, Rajan Bhattacharyya
  • Patent number: 10307593
    Abstract: A neuromodulation system executes a set of startup operations. In response to completion of the startup operations, a priming field is automatically initiated. The priming field is to produce a priming effect in priming-targeted neural tissue, with the priming effect causing a change in sensitization to a therapeutic neuromodulation field of the priming-targeted neural tissue. The system also generates the therapeutic neuromodulation field to produce a therapeutic effect in therapy-targeted neural tissue.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: June 4, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Que T. Doan, Bradley Lawrence Hershey, Changfang Zhu
  • Patent number: 10307594
    Abstract: Front-end analog circuitry is described based on a sink-regulated H-bridge topology for delivery of biphasic stimulus signals that may be useful in neurostimulation. Stimulus current may be supplied using fully-integrated dynamic voltage supplies (DVSs), which may be controlled in closed-loop to have an output voltage approximately equal to the voltage of the electrode each supplies stimulus to. The stimulus waveform may be regulated by a single, low-voltage current-digital-to-analog converter (current-DAC), which can safely interface with the electrodes (which may be at high voltages) via high-voltage adapter (HVA) circuits. Example analog front-end circuitry may utilize the balancing stimulus current to discharge the electrode-tissue interface impedance (ZE). In some examples, only after full (or sufficient) ZE discharge has been detected is a DVS used to supply the remaining balancing stimulus.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: June 4, 2019
    Assignee: University of Washington
    Inventors: Eric Pepin, Jacques Christophe Rudell
  • Patent number: 10307595
    Abstract: A therapeutic neuromodulation system configured for providing therapy to a patient. The therapeutic neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of electrodes implanted within tissue, analog output circuitry configured for delivering therapeutic electrical energy between the plurality of electrical terminals in accordance with a set of modulation parameters that includes a defined current value, a voltage regulator configured for supplying an adjustable compliance voltage to the analog output circuitry, and control/processing circuitry configured for automatically performing a compliance voltage calibration process at a compliance voltage adjustment interval by periodically computing an adjusted compliance voltage value as a function of a compliance voltage margin.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: June 4, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Jess Weiqian Shi, Jordi Parramon, Goran N. Marnfeldt
  • Patent number: 10307596
    Abstract: Devices and methods for single therapy pulse (STP) therapy for tacharrythmia are disclosed. The STP therapy can be delivered from a far-field position to allow a “global” capture approach to pacing. Due to the global capture in STP, a series of pulses, which is indicative of conventional anti-tachycardia pacing (ATP) delivered by transvenous systems, becomes unnecessary. One to four pulses at most are needed for STP, and after delivery of the one to four pulses, therapy delivery can be interrupted to determine whether the previously delivered therapy has been successful.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: June 4, 2019
    Assignee: Cameron Health, Inc.
    Inventors: James M. Keefe, Rick Sanghera
  • Patent number: 10307597
    Abstract: There is provided a method for controlling a flow of urine in the urinary passageway of a patient's urethra, ureter, renal pelvis or bladder. The method comprises gently constricting (i.e., without substantially hampering the blood circulation in the urinary tissue wall) at least one portion of the urinary tissue wall to influence the flow in the urinary passageway, and stimulating the constricted wall portion to cause contraction of the wall portion to further influence the flow in the urinary passageway. The method can be used for restricting or stopping the flow in the urinary passageway of a urinary incontinent patient, or for actively moving the urine in the urinary passageway, with a low risk of injuring the urethra, ureter, renal pelvis or bladder.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: June 4, 2019
    Inventor: Peter Forsell