Patents Issued in July 25, 2019
  • METHOD OF RECYCLING MOTHER LIQUID OF PTA REFINING UNIT
    Publication number: 20190225569
    Abstract: The present invention relates to a method of recycling mother liquid of a PTA refining unit. The present invention recycles waste heat and PT acids of a PTA mother liquid to effectively utilize heat in the PTA mother liquid, solves influence of crystallization of the PT acids on subsequent system, reduces pollution to the environment, and can produce huge economic benefits by using high efficient multistage flash distillation technology, low temperature cogeneration technology, heat pump heating and cooling technology, and low temperature crystallization technology.
    Type: Application
    Filed: May 15, 2017
    Publication date: July 25, 2019
    Inventors: Xu ZHAO, Tao SHEN, Tianbao WANG, Wanyao ZHANG, Yuanrui LU, Lilong XU, Min JIA, Dongzhao HAN, Xiaoling XIE, Yongning QIU
  • METHOD FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID AND DERIVATIVES THEREOF
    Publication number: 20190225570
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Application
    Filed: February 14, 2019
    Publication date: July 25, 2019
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
  • BIFUNCTIONAL COMPOUND HAVING NORBORNANE SKELETON AND METHOD FOR PRODUCING SAME
    Publication number: 20190225571
    Abstract: The present invention is able to provide a bifunctional compound represented by formula (1). (In the formula, R1 represents COOCH3, COOC2H5, COOC3H7, COOC4H9 or CHO; and R2 represents H, CH3 or C2H5.
    Type: Application
    Filed: April 3, 2019
    Publication date: July 25, 2019
    Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventors: Takashi MOTOI, Mitsuharu KITAMURA, Manabu HIRAKAWA
  • METHOD FOR PRODUCING 1,4-DICYANOCYCLOHEXANE, 1,4-BIS(AMINOMETHYL)CYCLOHEXANE AND 1,4-CYCLOHEXANEDICARBOXYLIC ACID
    Publication number: 20190225572
    Abstract: A method for producing 1,4-dicyanocyclohexane, having a step of obtaining 1,4-dicyanocyclohexane by subjecting a heated concentrate of an aqueous ammonia solution of 1,4-cyclohexanedicarboxylic acid to a cyanation reaction.
    Type: Application
    Filed: September 28, 2017
    Publication date: July 25, 2019
    Applicant: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Akifumi IIDA, Yuta OHMORI, Emi NAKANO, Aoi YAMAZOE
  • VINYLOGOUS PHENETHYLAMINES AS NEUROTRANSMITTER RELEASERS
    Publication number: 20190225573
    Abstract: The disclosure provides monoamine neurotransmitter releaser and/or monoamine uptake inhibitor compounds having biogenic amine transporter activity but lacking substantial activity at 5-HT2 receptor subtypes. The phenethylamine or vinylogous phenethylamine compounds of the disclosure are useful in treating diseases, conditions and/or disorders mediated by activity of one or more of the monoamine neurotransmitters.
    Type: Application
    Filed: May 11, 2017
    Publication date: July 25, 2019
    Inventors: Bruce Blough, Ann Decker, Richard Rothman
  • NEW CRYSTALLINE FORM OF GAMMA-AMINOBUTYRIC ACID AND PREPARATION METHOD THEREOF
    Publication number: 20190225574
    Abstract: A method for preparing a new crystalline form of ?-aminobutyric acid, including the steps of: S1: preparing a ?-aminobutyric acid solution at an initial concentration of 0.5-1.0 g/mL by adding crude ?-aminobutyric acid to water; adding an additive to the ?-aminobutyric acid solution, raising the temperature to 50-80° C., stirring to produce a clear solution; and S2: obtaining a suspension by evaporating water from the product of S1 under reduced pressure and at 50-80° C.; obtaining a wet product by filtering the suspension; drying the wet product to obtain the new crystalline form of ?-aminobutyric acid. The preparation method of the new crystalline form of ?-aminobutyric acid is simple, easy to operate, low in energy consumption, economical and environmentally friendly. It is suitable for large-scale industrial production.
    Type: Application
    Filed: November 7, 2016
    Publication date: July 25, 2019
    Inventors: Junbo Gong, Kaifei Zhao, Haiyan Xi, Xiaohua Wu, Baohong Hou, Qiuxiang Yin, Jingkang Wang, Feng Jin, Shichao Du, Qinqing Gu, Shiping Tang
  • ANTIVIRAL COMPOUNDS
    Publication number: 20190225575
    Abstract: The present invention relates to novel compounds of general formula (I) wherein the groups X, and R1 to R4 have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16.
    Type: Application
    Filed: September 12, 2017
    Publication date: July 25, 2019
    Inventors: Wolfgang Fischl, Mark Whittaker, Christopher John Yarnold, Jean-Francois Pons, Mark Anthony Kerry, Patricia Leonie Amouzegh, Inaki Morao, Peter Neville Ingram, Ewa Iwona Chudyk
  • PROCESS FOR PRODUCING UNSATURATED NITRILE
    Publication number: 20190225576
    Abstract: A process for producing unsaturated nitrile, using a fluidized bed reactor having an internal space having a catalyst capable of being fluidized therein, a feed opening to feed a starting material gas comprising hydrocarbon to the internal space, and a discharge port to discharge a reaction product gas from the internal space, the process comprising a reaction step of subjecting the hydrocarbon to a vapor phase catalytic ammoxidation reaction in the presence of the catalyst in the internal space to produce the corresponding unsaturated nitrile, wherein when in the internal space, a space where an existing amount of the catalyst per unit volume is 150 kg/m3 or more is defined as a dense zone and a space where an existing amount of the catalyst per unit volume is less than 150 kg/m3 is defined as a sparse zone in the reaction step, a gas residence time in the sparse zone is 5 to 50 sec.
    Type: Application
    Filed: June 8, 2018
    Publication date: July 25, 2019
    Applicant: ASAHI KASEI KABUSHIKI KAISHA
    Inventors: Sho TAMURA, Dai NAGATA
  • SULFONYLAMINOBENZAMIDE COMPOUND AND PEST CONTROL AGENT
    Publication number: 20190225577
    Abstract: A compound represented by formula (I) or a salt thereof. In formula (I), R1 and R4 each independently represent a hydrogen atom, or an unsubstituted or substituted C1 to C6 alkyl group or the like. R2 represents a hydrogen atom, or an unsubstituted or substituted C1 to C6 alkyl group or the like. R3 represents an unsubstituted or substituted C1 to C6 alkyl group or the like. R5 represents a C1 to C6 haloalkyl group or the like. G represents an oxygen atom or a sulfur atom. R6 and R7 each independently represent a hydrogen atom, or an unsubstituted or substituted C1 to C6 alkyl group or the like. n represents 0 or 1. R8 and R9 each independently represent a hydrogen atom, or an unsubstituted or substituted C1 to C6 alkyl group. Ar represents an unsubstituted or substituted C6 to C10 aryl group or the like.
    Type: Application
    Filed: August 28, 2017
    Publication date: July 25, 2019
    Applicant: Nippon Soda Co., Ltd.
    Inventors: Jun TAKAHASHI, Tetsuro KATO, Takao IWASA
  • PROCESS FOR TREATING KERATIN FIBRES WITH A CATIONIC DISULFIDE COMPOUND
    Publication number: 20190225578
    Abstract: The invention relates to a process for treating keratin fibres, in particular human keratin fibres such as the hair, comprising: (i) a step of applying a compound (I) and also the acid or base salts thereof, the optical or geometrical isomers thereof, and the solvates thereof such as hydrates, in which compound of formula (I): R1, R2, R3, R4, x, m, n, X?, are as defined in the description; (ii) a step of heating the keratin fibres to a temperature of at least 100° C., preferably ranging from 100 to 250° C.; it is understood that steps (i) and (ii) may be performed at the same time or separately. The process makes it possible to obtain good hair-conditioning cosmetic properties, with a long-lasting effect. The invention also relates to the novel compounds and to a cosmetic composition comprising such a compound.
    Type: Application
    Filed: November 10, 2016
    Publication date: July 25, 2019
    Inventors: Christian BLAISE, Virginie BURCKBUCHLER
  • TREATMENT OF FABRY DISEASE
    Publication number: 20190225579
    Abstract: Disclosed herein are novel uses of a polyhydroxylated pyrrolidine for the manufacture of a medicament for treating Fabry disease (FD). Accordingly, the present disclosure provides a method of treating a subject having or suspected of having FD. The method includes the step of, administering to the subject a therapeutically effective amount of a compound of formula (I), a salt, an ester or a solvate thereof, wherein: R1 is H, or C1-3 amine optionally substituted with —COR2; R2 is alkyl or alkene optionally substituted with cycloalkyl or phenyl having at least one substituent selected from the group consisting of, halo, alkyl, haloalkyl, and alkoxyl; so as to ameliorate, alleviate mitigate and/or prevent symptoms associated with the FD. According to preferred embodiments of the present disclosure, the compound of formula (I) is a chaperon of a mutated human lysosomal ?-galactosidase A (?-Gal A).
    Type: Application
    Filed: June 14, 2017
    Publication date: July 25, 2019
    Applicant: Academia Sinica
    Inventor: Wei-Chieh CHENG
  • PROCESS FOR PRODUCTION OF GLYCOPYRRONIUM TOSYLATE
    Publication number: 20190225580
    Abstract: Provided herein are methods for the production of glycopyrronium tosylate and glycopyrronium tosylate compositions. Also provided herein are compositions useful in the production of glycopyrronium tosylate. Additionally provided herein are glycopyrronium tosylate compositions. Glycopyrronium tosylate is useful for the treatment of, among other conditions, hyperhidrosis.
    Type: Application
    Filed: March 29, 2019
    Publication date: July 25, 2019
    Inventors: Anthony Adrian Shaw, Enrico Vigano, Renato Molteni
  • MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES
    Publication number: 20190225581
    Abstract: The present invention relates to compounds of formula (1). The compounds are suitable for use in electronic devices, in particular organic electroluminescent devices, comprising these compounds. In some embodiments, the compounds are used as matrix materials for phosphorescent or fluorescent emitters as well as a hole-blocking or electron-transport materials.
    Type: Application
    Filed: October 2, 2017
    Publication date: July 25, 2019
    Inventor: KATJA SCHEIBLE
  • METHOD FOR PREPARING PHENYLALANINE COMPOUND
    Publication number: 20190225582
    Abstract: Disclosed is a method for preparing 2-(2-(4-fluorobenzoyl)phenylamino)-3-(4-(2-(9H-carbazol-9-yl)ethoxy)phenyl)propanoic acid. In the method 9-carbazole ethanol mesylate and methyl 2-[2-(4-fluorobenzoyl)phenyl)amino]-3-(4-hydroxyphenyl)propionate are used as starting materials, and subjected to condensation, hydrolysis and acidification to obtain the target compound. The preparation method of the present invention is suitable for industrial production, and the target compound has a high purity.
    Type: Application
    Filed: September 27, 2017
    Publication date: July 25, 2019
    Applicant: SHENZHEN CHIPSCREEN BIOSCIENCES CO., LTD.
    Inventors: Xianping LU, Zhibin LI, Xianghui WANG
  • CARBAZOLE DERIVATIVES
    Publication number: 20190225583
    Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein Q, R1a, R1b, R2a, R2b, R3, R4, R5a, R5b, R6a, R6c, R7a, R7b, R7c, and R7d are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Application
    Filed: April 10, 2019
    Publication date: July 25, 2019
    Inventors: Saleem Ahmad, Douglas G. Batt, Qingjie Liu, John E. Macor, Joseph A. Tino, Scott Hunter Watterson, Satheesh Kesavan Nair, Tarun Kumar Maishal
  • LOW HYGROSCOPIC ARIPIPRAZOLE DRUG SUBSTANCE AND PROCESSES FOR THE PREPARATION THEREOF
    Publication number: 20190225584
    Abstract: The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous aripiprazole crystals is stored for an extended period.
    Type: Application
    Filed: October 24, 2018
    Publication date: July 25, 2019
    Inventors: Takuji BANDO, Satoshi AOKI, Junichi KAWASAKI, Makoto ISHIGAMI, Youichi TANIGUCHI, Tsuyoshi YABUUCHI, Kiyoshi FUJIMOTO, Yoshihiro NISHIOKA, Noriyuki KOBAYASHI, Tsutomu FUJIMURA, Masanori TAKAHASHI, Kaoru ABE, Tomonori NAKAGAWA, Koichi SHINHAMA, Naoto UTSUMI, Michiaki TOMINAGA, Yoshihiro OOI, Shohei YAMADA, Kenji TOMIKAWA
  • METHOD OF PRODUCING FLUORINE-CONTAINING PYRAZOLE CARBOXYLIC ACID HALIDE
    Publication number: 20190225585
    Abstract: The invention relates to a method of producing a compound represented by the formula (a) by reacting a compound represented by the formula (c) with a halogenating agent in a non-aqueous system: wherein R1 is a fluoroalkyl group having 1 to 3 carbon atoms, R2 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R3 is an alkyl group having 1 to 6 carbon atoms, and X is a halogen atom.
    Type: Application
    Filed: July 26, 2017
    Publication date: July 25, 2019
    Applicant: AGC Inc.
    Inventors: Yuichiro ISHIBASHI, Yasushi MATSUMURA, Osamu YOKOKOJI, Tamaki SHIMIZU
  • PROCESS FOR PREPARING 3-FLUOROALKYL-5-PYRAZOLECARBOXYLATES AND 3-FLUOROALKYL-5-PYRAZOLECARBOXYLIC ACIDS
    Publication number: 20190225586
    Abstract: The present invention relates to a novel process for preparing 3-fluoroalkyl-5-pyrazolecarboxylates from ketimines and oxalic acid derivatives which can be further transformed into 3-fluoroalkyl-5-pyrazolecarboxylic acids.
    Type: Application
    Filed: September 18, 2017
    Publication date: July 25, 2019
    Applicants: BAYER CROPSCIENCE AKTIENGESELLSCHAFT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Sergii PAZENOK, Jean-Pierre VORS, Frédéric R. LEROUX, Etienne SCHMITT
  • INDAZOLYL- AND INDOLYL-BENZAMIDE DERIVATIVES
    Publication number: 20190225587
    Abstract: The invention relates to indazolylbenzamide, indolylbenzamide, benzo[d]imidazolyl-benzamide, and benzo[d]triazolylbenzamide derivatives of formula useful in the treatment and/or prevention of diseases and/or conditions related to cell proliferation, such as cancer, infection, inflammation and inflammation-associated disorders, and conditions associated with angiogenesis.
    Type: Application
    Filed: April 2, 2019
    Publication date: July 25, 2019
    Inventor: Philip F. Hughes
  • Compositions for the Treatment of Hypertension and/or Fibrosis
    Publication number: 20190225588
    Abstract: The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.
    Type: Application
    Filed: September 21, 2017
    Publication date: July 25, 2019
    Inventor: Karen Annette DUGGAN
  • TRIAZOLE CONJUGATED UREAS, THIOUREAS, CARBAMATES, AND REVERSED CARBAMATES FOR PSMA-TARGETED IMAGING AGENTS AND USES THEREOF
    Publication number: 20190225589
    Abstract: Triazole conjugated urea-based and thiourea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used to image cells and tumors that express PSMA. Methods of synthesizing radiofluorinated triazole conjugated urea-based and thiourea-based scaffolds also are disclosed.
    Type: Application
    Filed: August 15, 2016
    Publication date: July 25, 2019
    Inventors: MARTIN G. POMPER, YING CHEN, XING YANG, RONNIE C. MEASE, SANGEETA RAY
  • METHOD FOR PREPARING FLUOROALKYLNITRILES AND THE CORRESPONDING FLUOROALKYLTETRAZOLES
    Publication number: 20190225590
    Abstract: The present invention relates to a method for preparing fluoroalkylnitriles and the corresponding fluoroalkyltetrazoles by reacting fluorinated carboxamides with phosphorus trichloride (PCl3) or phosphorus oxychloride (POCl3) in the presence of a base.
    Type: Application
    Filed: July 20, 2017
    Publication date: July 25, 2019
    Applicant: Bayer CropScience Aktiengesellschaft
    Inventors: Claus-Christian HAESELHOFF, Albert SCHNATTERER, Jan VERMEHREN
  • PROCESS FOR PREPARING 5-PHENOXY-1(3)ISOBENZOFURANONE
    Publication number: 20190225591
    Abstract: The disclosure provides a simple and efficient method for producing a compound of Formula I.
    Type: Application
    Filed: March 29, 2019
    Publication date: July 25, 2019
    Inventors: Zheqing Wang, Lilliam Wu, Yang Zhao, Zhenwei Li
  • ANTI-INFECTIVE AGENTS
    Publication number: 20190225592
    Abstract: The present invention relates to a novel class of chromene-2-carboxamide compounds inhibitors of general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and their use as anti-infective agents in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.
    Type: Application
    Filed: June 20, 2017
    Publication date: July 25, 2019
    Inventors: Barbara FORTE, Neil NORCROSS, Chimed JANSEN, Beatriz BARAGANA, Ian GILBERT, Laura CLEGHORN, Susan DAVIS, Christopher WALPOLE
  • SUBSTITUTED CHROMANE-8-CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF, AND METHODS USING SAME
    Publication number: 20190225593
    Abstract: The present invention includes novel substituted bicyclic (such as 4-substituted-chromane-8-carboxamide compounds), and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention are capsid inhibitors.
    Type: Application
    Filed: September 13, 2017
    Publication date: July 25, 2019
    Inventors: ANDREW G. COLE, STEVEN KULTGEN
  • Herbicidal Pyrimidine Compounds
    Publication number: 20190225594
    Abstract: The present invention relates to the pyrimidine compounds of formula (I), or their agriculturally acceptable salts or derivatives as herbicides, wherein the variables are defined according to the description, use of pyrimidine compounds of formula (I) as herbicide, compositions comprising them and their use as herbicides, i.e. for controlling harmful plants, and also a method for controlling unwanted vegetation which comprises allowing a herbicidal effective amount of at least one pyrimidine compounds of the formula (I) to act on plants, their seed and/or their habitat.
    Type: Application
    Filed: July 10, 2017
    Publication date: July 25, 2019
    Inventors: Florian VOGT, Matthias WITSCHEL, Veronica LOPEZ CARRILLO, Tobias SEISER, Thomas SEITZ, Gerd KRAEMER, Klaus REINHARD, Trevor William NEWTON, Doreen SCHACHTSCHABEL, Kristin HANZLIK
  • TUBULIN INHIBITOR
    Publication number: 20190225595
    Abstract: Provided are a new tubulin inhibitor and applications thereof, the tubulin inhibitor being a series of compounds based on substituted heterocyclic skeletons, targeting the colchicine binding sites of tubulin. The structure is: Formula (I), wherein: formula (A), n independently expresses an integer between 0 and 5, the condition being that n?5, A represents mono- or poly-substituted groups, the groups being selected from the group consisting of H, C1-C20 amide group, C1-C20 acyloxy group, C1-C20 alkanoyl group, C1-C20 alkoxycarbonyl group, C1-C20 alkoxy group, C1-C20 alkylamino group, C1-C20 alkylcarboxyamino group, aroyl group, aralkanoyl group, carboxyl group, cyano group, halogen group, hydroxyl group, nitro group and methylthienyl group.
    Type: Application
    Filed: September 29, 2017
    Publication date: July 25, 2019
    Inventors: Tian TANG, Yanqing WANG, Xiaorou LIU, Jin WANG, Ruyi JIN, Hanlin FENG
  • Cannabinergic Nitrate Esters And Related Analogs
    Publication number: 20190225596
    Abstract: The present technology relates to novel cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods of use as medicaments, pharmacological tools and/or biomarkers. The novel cannabinergic nitrate ester compounds provide medicaments useful in treating a variety of diseases and medical disorders.
    Type: Application
    Filed: January 4, 2019
    Publication date: July 25, 2019
    Inventors: Alexandros Makriyannis, Venkata Kiran Vemuri
  • PYRROLIDINE DERIVATIVES AS PPAR AGONISTS
    Publication number: 20190225597
    Abstract: The present invention discloses a class of pyrrolidine derivatives as PPAR agonist, and their use for the treatment of some diseases of PPAR receptor-associated pathways (such as nonalcoholic steatohepatitis and concurrent fibrosis, insulin resistance, primary biliary cholgangitis, dyslipidenmia, hyperlipidemia, hypercholesterolemia, atherosclerosis, hypertriglyceridemia, cardiovascular disease, obesity or the like). In particular, the present invention discloses a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 12, 2017
    Publication date: July 25, 2019
    Inventors: Zhiliang Yuan, Chaofeng Long, Zhigan Jiang, Xiaoxin Chen, Haiying He, Xing Liu, Xiao Zhang, Zhiqiang Liu, Yan Wang, Leilei Gao, Zhen Gong, Jian Li, Shuhui Chen
  • NOVEL CHEMOKINE CXCR1 AND CXCR2 RECEPTOR ANTAGONIST COMPOUNDS, AND USE THEREOF IN THE TREATMENT OF CHEMOKINE-MEDIATED PATHOLOGIES
    Publication number: 20190225598
    Abstract: Novel chemokine CXCR1 and CXCR2 receptor antagonist compounds of general formula (I) are described. Also described, are pharmaceutical compositions including the compounds, and use of the compounds and the compositions for the treatment of chemokine-mediated pathologies, more specifically in the field of dermatology.
    Type: Application
    Filed: April 2, 2019
    Publication date: July 25, 2019
    Applicant: GALDERMA RESEARCH & DEVELOPMENT
    Inventors: Branislav MUSICKI, Yushma BHURRUTH-ALCOR
  • RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF
    Publication number: 20190225599
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Application
    Filed: December 5, 2018
    Publication date: July 25, 2019
    Inventors: Ana Maria CUERVO, Evripidis GAVATHIOTIS, Qisheng XIN, Bhaskar C. DAS
  • BENZOFURAN PYRAZOLE AMINE KINASE INHIBITOR
    Publication number: 20190225600
    Abstract: The present invention discloses a compound for regulating protein kinase activity and used for treating or preventing diseases associated with protein kinases. Specifically, the present invention relates to a benzofuran pyrazole amine protein kinase inhibitor which belongs to compounds that regulate anaplastic lymphoma kinase (ALK), and provides a method of preparing such a compound and a pharmaceutical use of such a compound in the treatment or prevention of diseases associated with ALK. The inhibitor can solve the problem of the drug resistance of the first generation and the second generation of ALK inhibitors.
    Type: Application
    Filed: June 27, 2017
    Publication date: July 25, 2019
    Inventors: Yonghui WANG, Juan ZHOU, Yujun GAO, Dong WANG, Binbin HONG, Ximing SHEN, Yaodong WU, Chunqi LI
  • HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
    Publication number: 20190225601
    Abstract: Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
    Type: Application
    Filed: April 2, 2019
    Publication date: July 25, 2019
    Inventors: Liangxing Wu, Jingwei Li, Chao Qi, Fenglei Zhang, Zhenwu Li, Wenyu Zhu, Zhiyong Yu, Kaijiong Xiao, Liang Lu, Song Mei, Ding-Quan Qian, Chunhong He, Yingda Ye, Meizhong Xu, Wenqing Yao
  • Propionic Acid Derivatives and Methods of Use Thereof
    Publication number: 20190225602
    Abstract: Provided herein are methods for antagonizing the action of an ?4-integrin to treat various pathophysiological conditions utilizing pharmaceutical compositions of compounds or pharmaceutically acceptable salts or stereoisomer(s) thereof of formula I where R1, R2, R3, R4, R5, X and R6 are as described herein.
    Type: Application
    Filed: April 1, 2019
    Publication date: July 25, 2019
    Applicant: Aviara Pharmaceuticals, Inc.
    Inventors: Ronald J. Biediger, Michele A. Benish, Robert V. Market, Michael M. Savage, Brandon M. Young
  • DIHYDROPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20190225603
    Abstract: The present invention relates to a dihydropyrimidine compound having an antiviral activity, a pharmaceutical composition comprising same, a preparation method therefor and the uses thereof in the prevention or treatment of viral diseases including, but not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).
    Type: Application
    Filed: November 9, 2017
    Publication date: July 25, 2019
    Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.
    Inventors: Shuai SONG, Jiaqiang CAI, Qiang TIAN, Hong ZENG, Hongmei SONG, Hanwen DENG, Zujian TANG, XIAOFAN DUAN, Rongrong LONG, Yao LIU, Lichun WANG, Jingyi WANG
  • PYRAZOLOPYRIDINE DERIVATIVE HAVING GLP-1 RECEPTOR AGONIST EFFECT
    Publication number: 20190225604
    Abstract: The present invention provides a compound having the basic structure shown by Formula (I) in which the indole ring and the pyrazolopyridine structure is bound through a substituent, a salt thereof or a solvate of either the compound or a salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound, salt or solvate as an active ingredient.
    Type: Application
    Filed: September 26, 2017
    Publication date: July 25, 2019
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hitoshi YOSHINO, Satoshi TSUCHIYA, Atsushi MATSUO, Tsutomu SATO, Masahiro NISHIMOTO, Kyoko OGURI, Hiroko OGAWA, Yoshikazu NISHIMURA, Yoshiyuki FURUTA, Hirotaka KASHIWAGI, Nobuyuki HORI, Takuma KAMON, Takuya SHIRAISHI, Shoshin YOSHIDA, Takahiro KAWAI, Satoshi TANIDA, Masahide AOKI
  • DEUTERATED PALBOCICLIB
    Publication number: 20190225605
    Abstract: This invention relates to novel pyrido[2,3-d]pyrimidinones of Formula I: and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a CDK-4 and/or CDK-6 inhibitor.
    Type: Application
    Filed: November 13, 2018
    Publication date: July 25, 2019
    Inventor: Adam J. Morgan
  • Novel Imidazopyridine Thioglycolic Acid Derivatives as Potent Inhibitors of Human Urate Transporter 1
    Publication number: 20190225606
    Abstract: It relates to the imidazopyridine thioglycolic acid derivatives, the preparation, and use thereof. The invention contained imidazopyridine thioglycolic acid derivatives with the formula I or II or III. Also described here are preparation of imidazopyridine thioglycolic acid derivatives, pharmaceutical compositions comprising these compounds as therapy and prevention for gout.
    Type: Application
    Filed: September 2, 2016
    Publication date: July 25, 2019
    Applicant: Shandong University
    Inventors: Xinyong LIU, Qing MENG, Peng ZHAN, Zengjun FANG, Tong ZHAO, Zhuosen SUN, Xiukun SUN
  • Deuterated Venetoclax
    Publication number: 20190225607
    Abstract: This invention relates to deuterated forms of venetoclax, and pharmaceutically acceptable salts thereof. Certain aspects of this invention also provide pharmaceutical compositions comprising a compound of the present invention and a pharmaceutically acceptable carrier. Certain aspects of the present invention also provide the use of such compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of the anti-apoptotic activity of the B-cell lymphoma 2 (Bcl-2) protein.
    Type: Application
    Filed: June 30, 2017
    Publication date: July 25, 2019
    Inventor: Roger Tung, Ph.D.
  • NOVEL POLYMORPH OF AN INTERMEDIATE FOR PALBOCICLIB SYNTHESIS
    Publication number: 20190225608
    Abstract: The present disclosure provides a novel polymorph of an intermediate useful in the preparation of palbociclib. The polymorph has enhanced properties that influence process ability of the intermediate and synthesis of palbociclib.
    Type: Application
    Filed: October 4, 2017
    Publication date: July 25, 2019
    Applicant: MYLAN LABORATORIES LIMITED
    Inventors: Mahdeshkumar Gadakar, Dnyandeo Punde, Rajendra Yadav, Yogesh Wakchaure
  • FLUORINATED TETRAHYDRONAPHTHYRIDINYL NONANOIC ACID DERIVATIVES AND USES THEREOF
    Publication number: 20190225609
    Abstract: The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing the fluorinated compounds of the invention, and methods of treating fibrosis, macular degeneration, diabetic retinopathy (DR), macular edema, diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO), by administering these compounds and pharmaceutical compositions to subjects in need thereof.
    Type: Application
    Filed: April 3, 2019
    Publication date: July 25, 2019
    Inventors: Ben C. ASKEW, Takeru FURUYA
  • DEUTERATED 3-(4,5-SUBSTITUTED AMINOPYRIMIDINE)PHENYL DERIVATIVES AND USE THEREOF
    Publication number: 20190225610
    Abstract: A type of deuterated 3-(4,5-substituted aminopyrimidine)phenyl derivatives and use thereof. The derivatives are compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds or salts thereof can be used for treatment or prevention of diseases or illnesses through certain mutant forms of epidermal growth factor receptors, inhibit the growth of various tumor cells effectively, and inhibit other proteases of EGFR and Her families, they can be used for preparing anti-tumor drugs.
    Type: Application
    Filed: September 18, 2017
    Publication date: July 25, 2019
    Inventors: Yongqiang ZHU, Zhaogang LIU, Chao FENG, Shihe HU, Hao CHEN, Enhe BAI, Jie WANG, Jingmiao SHI
  • SUBSTITUTED SPIROCYCLIC INHIBITORS OF AUTOTAXIN
    Publication number: 20190225611
    Abstract: The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
    Type: Application
    Filed: April 12, 2019
    Publication date: July 25, 2019
    Inventors: Lee BABISS, Matthew CLARK, Anthony D. KEEFE, Mark J. MULVIHILL, Haihong NI, Louis RENZETTI, Frank RUEBSAM, Ce WANG, Zhifeng XIE, Ying ZHANG
  • 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE
    Publication number: 20190225612
    Abstract: The present invention relates to compounds of Formula A and pharmaceutical compositions thereof that modulate the activity of the 5-HT2C receptor.
    Type: Application
    Filed: August 18, 2017
    Publication date: July 25, 2019
    Inventors: Graeme Semple, Albert S. Ren, Thomas O. Schrader, Michelle Kasem, Xiuwen Zhu
  • Compounds For Repressing Cancer Cell Growth
    Publication number: 20190225613
    Abstract: The disclosure generally relates to compounds, compositions, and methods for the treatment of cancer by restoring the P53 pathway signaling to repress cancer cell growth.
    Type: Application
    Filed: January 23, 2019
    Publication date: July 25, 2019
    Inventors: Wafik S. El-Deiry, Shengliang Zhang, Liz J. Hernandez Borrero
  • CRYSTALS OF [2-(1-METHYL-1H-PYRAZOL-4-YL)-6(MORPHOLIN-4-YL)-9H-PURIN-8-YL][4-(MORPHOLIN-4-YL)PIPERIDIN-1-YL]METHANONE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
    Publication number: 20190225614
    Abstract: Provided are novel crystals of [2-(1-methyl-1H-pyrazol-4-yl)-6-(morpholin-4-yl)-9H-purin-8-yl][4-(morpholin-4-yl)piperidin-1-yl]methanone and a pharmaceutically acceptable salt thereof having advantageous characteristics. [2-(1-Methyl-1H-pyrazol-4-yl)-6-(morpholin-4-yl)-9H-purin-8-yl][4-(morpholin-4-yl)piperidin-1-yl]methanone and a pharmaceutically acceptable salt thereof provided by the present invention are excellent in stability and have satisfactory physical properties as a drug substance of a pharmaceutical product.
    Type: Application
    Filed: September 28, 2017
    Publication date: July 25, 2019
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Yasushi Ueda, Sagar Ramdas Amale, Manjunath Govind Bhovi
  • PURINE AND 3-DEAZAPURINE ANALOGUES AS CHOLINE KINASE INHIBITORS
    Publication number: 20190225615
    Abstract: There are provided substituted purine and 3-deazapurine analogues, which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune-related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: July 19, 2017
    Publication date: July 25, 2019
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Elena CASALE, Emliana CORTI, Paola GNOCCHI, Marcella NESI, Sten Christian ORRENIUS, Francesca QUARTIERI, Federico RICCARDI SIRTORI
  • METHODS OF PREPARING CO-CRYSTALS OF IBRUTINIB WITH CARBOXYLIC ACIDS
    Publication number: 20190225616
    Abstract: The present invention relates to co-crystals of ibrutinib and a pharmaceutical composition comprising the same as well as a method of preparing the same.
    Type: Application
    Filed: November 28, 2018
    Publication date: July 25, 2019
    Applicant: ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Jens Geier, Sebastian Rabe, David Perez Palacios
  • RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME
    Publication number: 20190225617
    Abstract: The invention is a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Values for the variables are provided herein. Also included is a pharmaceutical composition comprising the compound represented by Structural Formula (I) and a pharmaceutically acceptable carrier or diluent and methods of treating a subject with cancer with the compound of Structural Formula (I).
    Type: Application
    Filed: January 28, 2019
    Publication date: July 25, 2019
    Inventors: Radoslaw Laufer, Grace Ng, Richard Brokx, Heinz W. Pauls, Sze-Wan Li, Jacqueline M. Mason, Mark R. Bray
  • IDO Inhibitors
    Publication number: 20190225618
    Abstract: Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease.
    Type: Application
    Filed: February 7, 2019
    Publication date: July 25, 2019
    Inventors: Mario Mautino, Sanjeev Kumar, Jesse Waldo, Firoz Jaipuri, Tanay Kesharwani, Xiaoxia Zhang