Abstract: The present disclosure relates to systems and methods for high efficiency electronic sequencing of nucleic acids and molecular detection.

Abstract: The present invention provides genotyping methods and compositions for selecting patients with cardiovascular disease who will benefit from treatment with HDL-raising or HDL mimicking agent, in particular with a CETP inhibitor/modulator.

Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.

Abstract: The present disclosure relates to methods and compositions for making paired tags and paired tag libraries.

Abstract: Provided is a method for evaluating the risk of drug hypersensitivity reaction induced by antibiotics sulfamethoxazole and/or trimethoprim. The drug hypersensitivity reaction comprises: maculopapular eruption, fixed drug eruption, Stevens-Johnson Syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms. A specific HLA genotype is associated with the drug hypersensitivity reaction induced by the antibiotics sulfamethoxazole and/or trimethoprim.

Abstract: A method of determining one or more target nucleic acids in cells includes the steps of: delivering one or more probes into the cells, each of the one or more probes being capable of binding with corresponding target nucleic acid present in the cells to form a double-stranded sequence; inserting an array of functionalized nanoneedles into the cells to bind with the double-stranded sequence; and hybridizing the bound double-stranded sequence with a first and second DNA sequence to produce a hybridized product, the first and second DNA sequence being at least partially complementary to each other. A kit for determining a target nucleic acid in cells includes a first reagent comprising a probe for binding with the target nucleic acid to form a double-stranded sequence; and an array of functionalized nanoneedles comprising a protein for binding with the double-stranded sequence.

Abstract: The present invention provides methods and systems for identify bovine spongiform encephalopathy in bovine, and related uses, agents, and kits. The invention includes and methods for detecting and diagnosing BSE.

Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with psoriasis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, such as a haplotype, a diplotype, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

Abstract: Some embodiments are directed to a prognostic method for determining whether a subject is at risk of having the CLAD, comprising: measuring the expression level of POU2AF1 or BLK in a biological sample obtained from the subject; comparing the expression level of POU2AF1 or BLK with a predetermined reference value and concluding that the subject is at risk of having CLAD when the expression level of POU2AF1 or BLK is lower than the predetermined reference value.

Abstract: Collections of polynucleotides useful for estimating breeding value or detecting likelihood of an increased susceptibility to contracting paratuberculosis are disclosed. The polynucleotides are used to detect genomic sequences quantitatively associated with an increased susceptibility to contracting paratuberculosis. Methods for using the collections to estimate breeding value or predict likelihood of an increased susceptibility to contracting paratuberculosis are also provided. Kits comprising the collection of polynucleotides are also provided.

Abstract: The invention generally relates to methods for assessing the health of a tissue by characterizing circulating nucleic acids in a biological sample. According to certain embodiments, methods for assessing the health of a tissue include the steps of detecting a sample level of RNA in a biological sample, comparing the sample level of RNA to a reference level of RNA specific to the tissue, determining whether a difference exists between the sample level and the reference level, and characterizing the tissue as abnormal if a difference is detected.

Abstract: The present invention is directed to methods for detecting a colon cancer, methods for determining whether a colon cancer is stable or progressive, methods for determining a risk for disease relapse, and methods for determining a response by a subject having a colon cancer to a therapy.

Abstract: An object of the present invention is to provide a method capable of conveniently carrying out amplification of methylated DNA, and determination of methylation of DNA and determination of the occurrence of cancer using the amplification of methylated DNA. The present invention relates to “a method for amplifying a methylated analysis target region; a method for determining the methylation of an analysis target region; a reagent for use in the determination of methylation; a method for determining the occurrence of cancer; a method for obtaining data for determining the occurrence of cancer; a reagent for use in the determination of the occurrence of cancer; and a marker for use in the determination of the occurrence of cancer”.

Abstract: The present invention relates to a method for diagnosing breast cancer in a patient or for determining whether a patient will respond to a therapeutic treatment of breast cancer. Further, the present invention relates to the use of at least one polynucleotide for detecting at least one miRNA for diagnosing breast cancer in a blood sample from a patient or for determining whether a patient will respond to a therapeutic treatment of breast cancer in a blood sample from the patient. Furthermore, the present invention relates to the use of at least one miRNA isolated from a blood sample from a patient for diagnosing breast cancer or for determining whether the patient will respond to a therapeutic treatment of breast cancer. In addition, the present invention relates to a kit for diagnosing breast cancer in a patient or for determining whether a patient will respond to a therapeutic treatment of breast cancer.

Abstract: A method for detecting small RNA or small RNA-associated protein, and more particularly to a method of detecting small RNA or small RNA-associated protein using a promer is provided. It has the structure X-Y-Z and has a nucleotide sequence capable of binding complementarily to the whole or a part of the small RNA to be detected. The present invention makes it possible to rapidly and accurately detect the small RNA or the small RNA-associated protein, and thus may be advantageously used for diagnosis of various diseases and prognostic prognosis.

Abstract: Specific mutations of FGFR3 (S249C) and of TP53 (V272M) are identified as being characteristic of breast cancer, and of having utility in diagnosis and prognosis of an individual with breast cancer. Systems and methods useful for identification of such mutations are also presented.

Abstract: The present invention provides methods for estimating the breeding value of individuals in populations such as those having small effective population size (Ne) e.g., to identify selection candidates having high breeding values, wherein the methods comprise inferring one or more genotypes for one or more markers at a locus or QTL to be the same as for an ancestor or founder or a subset of ancestors and/or founders from which a corresponding chromosome segment is derived and estimating the breeding value of the individual based on the inferred genotype(s).

Abstract: The present disclosure relates to a Clostridium sp. JS66 strain producing metabolites having 4 to 6 carbon atoms in a high yield. The strain produces metabolites having 6 carbon atoms in a significantly high yield while reducing the production of acetic acid and ethanol as by-products.

Abstract: A method for producing a steel member includes carburizing the steel member, pearlitizing austenite, and performing quenching. The pearlitizing of the austenite includes performing a first pearlite precipitation treatment of cooling the steel member to a first temperature lower than an austenite transformation start temperature and higher than 680° C. and holding the steel member at the first temperature to pearlitize a part of the austenite formed in the carburizing of the steel member, and performing a second pearlite precipitation treatment of further cooling the steel member to a second temperature equal to or lower than 680° C. and higher than a nose temperature and holding the steel member at the second temperature to pearlitize the austenite retained in the first pearlite precipitation treatment.

Abstract: The invention relates to a cooling device (100) for cooling at least one element (150, 151) passing through said device, comprising a metal block (115), having a first side and a second side, and comprising a cooling channel (130) for cyrogenic gas. The at least one element (150, 151) can be guided along the sides of the first side of the metal block (115), the cooling channel (130) is at least partially in heat conductive connection with the second side of the metal block (115), and the cooling channel (130) has an attachment (131) on a first end for the entry of cryogenic gas and an attachment on a second end for the exit of cryogenic gas. The invention also comprises a hardening device having such a cooling device (100) and a method for cooling at least one element (150, 151) passing through said device.

Abstract: Provided herein is a high-strength seamless steel pipe containing a particular chemical composition. The volume fraction of tempered martensite is 90% or more in terms of a volume fraction. The number of nitride inclusions with a particle diameter of 4 ?m or more is 50 or less per 100 mm2, the number of nitride inclusions with a particle diameter of less than 4 ?m is 500 or less per 100 mm2, the number of oxide inclusions with a particle diameter of 4 ?m or more is 40 or less per 100 mm2, and the number of oxide inclusions with a particle diameter of less than 4 ?m is 400 or less per 100 mm2 in a cross section perpendicular to a rolling direction.

Abstract: The invention relates to the field of railway, and discloses a hypereutectoid rail and a manufacturing method thereof, which includes rolling a steel billet containing V and Ti, wherein, based on its total weight, the steel billet contains C of 0.85-0.94 wt %, and the relation between the start rolling temperature Tstart/final rolling temperature Tfinal and the content of V and the content of Ti satisfies the following formulas: Tstart=1100+a([V]+5[Ti]), Tfinal=750+b([V]+5[Ti]), wherein, 500?a?800, 300?b?500; based on its total weight, the steel billet contains V of 0.03-0.08 wt %, Ti of 0.011-0.02 wt %, and [V]+5[Ti]: 0.12-0.14 wt %. The hypereutectoid rail manufactured with the method has excellent comprehensive performance of strength and toughness.

Abstract: A method for manufacturing of steel tube from a long steel strip, including providing a length of steel strip material to the process, forming a tube of the steel strip material, welding the formed tube in longitudinal direction, giving the tube a heat treatment wherein the mentioned steps are performed in one continuous in-line manufacturing line and the heat treatment includes a heating regime such that in successive cross-sections of the tube a microstructure is achieved which holds at least 50 vol % austenite and a cooling trajectory to re-introduce ferrite, and/or bainite in desired volume fractions.

Abstract: A method for producing a high strength tube part is provided. The method includes the acts of: producing a sheet metal blank, producing a tube part by cold forming the sheet metal blank, and hardening the tube part at least in some sections to a high strength tube part.

Abstract: A method for manufacturing an ultra-hard and wear-resistant composite blade, comprising the following steps: carrying out pre-blank-fabricating and pre-matrix-forming treatments on a blade matrix (2) material to form a preformed blank; adding an ultra-hard alloy material in the preformed blank by means of an ultra-high-temperature melting treatment; after cooling, machining and grinding according to the blade specifications to obtain the ultra-hard, wear-resistant and antirust composite blade. The composite blade manufactured using the method has ultra-high hardness, wear resistance and blank antirust performance; moreover, the cutting edge of the nanoscale ultra-hard alloy body is durable and sharp and is not liable to wear.

Abstract: A ferritic stainless steel sheet is a ferritic stainless steel sheet which is temper rolled after bright annealing and has a passivation film. The area ratio of minute defects having an area of 10 ?m2 or more on the surface of the steel sheet is 0.2% or more and 1.5% or less. In addition, the thickness of the passivation film is 1 nm or more and 10 nm or less, the average concentration of Si in the passivation film is 10 at % or more and 20 at % or less, and the average concentration ratio of Si, Al, Cr and Fe in the passivation film component is (Si+Al+Cr)/Fe>1.0.

Abstract: A hot-rolled and annealed ferritic stainless steel sheet which has sufficient corrosion resistance and with which it is possible to inhibit a crack from occurring when punching work is performed to form a thick-walled flange and a method for manufacturing the steel sheet. The hot-rolled and annealed ferritic stainless steel sheet has a chemical composition comprising, by mass %, C: 0.001% to 0.020%, Si: 0.05% to 1.00%, Mn: 0.05% to 1.00%, P: 0.04% or less, S: 0.01% or less, Al: 0.001% to 0.100%, Cr: 10.0% to 24.0%, Ni: 0.01% to 0.60%, Ti: 0.10% to 0.40%, N: 0.001% to 0.020%, and the balance being Fe and inevitable impurities, and a threshold stress intensity factor KIC of 20 MPa·m1/2 or more.

Abstract: A steel sheet according to an aspect of the present invention has a chemical composition within a predetermined range; in which a metallographic structure at a thickness ¼ portion includes, by unit area %, ferrite: 10% or more and less than 50%, granular bainite: 5% or more and less than 50%, and martensite: 20% or more and less than 60%; in the metallographic structure at the thickness ¼ portion, a total of upper bainite, lower bainite, residual austenite, and pearlite is 0% or more and less than 15% by unit area %; at the thickness ¼ portion, a product of an area ratio Vm of the martensite and an average hardness Hv of the martensite is 12,000 to 34,000; and a tensile strength is 980 MPa or higher.

Abstract: This ferritic stainless steel contains, by mass %, C: 0.001% to 0.030%; Si: 0.01% to 1.00%. Mn: 0.01% to 2.00%, P: 0.050% or less, S: 0.0100% or less, Cr: 11.0% to 30.0%, Mo: 0.01% to 3.00%, Ti: 0.001% to 0.050%, Al: 0.001% to 0.030%, Nb: 0.010% to 1.000%, and N: 0.050% or less, with a remainder being Fe and inevitable impurities, wherein an amount of Al, an amount of Ti, and an amount of Si (mass %) satisfy Al/Ti?8.4Si-0.78.

Abstract: Disclosed is a method for producing a steel part, which includes the steps of: preparing a built-up steel sheet including a steel sheet 20 including: C: 0.15 to 0.5% by mass, Si: 0.10 to 3% by mass, Mn: 0.5 to 5% by mass, P: 0.05% by mass or less (excluding 0%), S: 0.05% by mass or less (excluding 0%), Al: 0.01 to 1% by mass, B: 0.0002 to 0.01% by mass, Ti: 0.005 to (3.4[N]+0.1) % by mass (in which [N] represents a content of N (% by mass)), and N: 0.001 to 0.01% by mass, with the balance being iron and inevitable impurities, and one or more built-up portions 30 provided on the steel sheet 20; hot-forming the built-up steel sheet at a temperature of an Ac3 point or higher of the steel sheet 20; and cooling the hot-formed built-up steel sheet to a temperature of an Ms point or lower of the steel sheet such that an area ratio of martensite in the metal structure of the steel sheet 20 is 70% or more.

Abstract: A method for peening an obstructed region of a metal assembly that is obstructed by an obstructing part of the metal assembly is provided. The method includes determining an optimal peening path for treating the obstructed region irrespective of the obstructing part; identifying a portion of the obstructing part within the optimal peening path; determining a section of the portion of the obstructing part that is removable without affecting a mechanical integrity and functionality of the obstructing part; removing, by machining, the section so as to create additional space along the optimal peening path; and peening the obstructed region, a path of the peening at least partially crossing through the additional space. A method for peening a nuclear reactor pressure vessel is also provided.

Abstract: The instant invention relates to a binder composition for pelletization of fine mineral particles comprising a) at least one colloid agent which exerts a cohesive force on the mineral particles forming the pellets, and b) at least one synthetic polymer which disperses mineral particles evenly in the pellets.

Abstract: A system and method for recycling metals from industrial waste using an electrodepositing technique. The method includes the steps of collecting the industrial waste, transporting, processing and digesting the waste in a solvent or acidic solution and then electrodepositing out the desired metals. Other processing steps may be used to prepare the industrial waste for electrodeposition and the process may be repeated on the digest solution, to obtain multiple metals.

Abstract: Disclosed is a method and a device for retrieving, from an object A, elements G present in a matrix M, the method including at least the following steps: bringing said abject A into contact with a dense fluid Fd with a molar mass greater than 2 g mol?1 under temperature T1 and pressure P1 conditions suitable for transforming the intergranular phase and for releasing the elements G,, modifying the temperature T2 and/or pressure P2 values to stop the reaction transforming the intergranular phase,, and recovering the elements G separated front the matrix M.

Abstract: A process for the recovery of precious metal (PM) from PM oil, the process including combustion of PM oil within a furnace, where the PM oil is burned in atomized form.

Abstract: A method of recovering a rare earth element. The method comprises dissolving a rare earth element magnetic material in a dissolution organic solvent and a ?-diketone compound to form a dissolved rare earth element mixture. A rare earth element of the rare earth element magnetic material and the ?-diketone compound are reacted to form a ?-diketonate chelate complex and the dissolution organic solvent is removed. The ?-diketonate chelate complex is removed using a separation organic solvent, and the ?-diketonate chelate complex is recovered. Additional methods are also disclosed.

Abstract: A process for separating rare earth elements (REE) from Ca, Mg and other non-REE elements comprises raising the pH of an acidic aqueous solution of REE to pH 8 to pH 11; adding nano- or micro (NoM) particles having a silica or titanium oxide surface; agitating the suspension for 6 h to 48 h to provide for adherent crystallization of REE hydroxide on the particles; separating the particles from the solution; releasing REE by treatment with aqueous acid to form an aqueous solution of REE salt; separating them from the aqueous solution of REE salt formed. The acidic aqueous solution comprising REE is preferably provided by leaching of an REE mineral with aqueous acid; adding a base to bring the pH to from pH 4.0 to pH 6.5; separating precipitated non-REE hydroxide from the solution.

Abstract: A metal alloy comprising effective amounts of gold, palladium, and silver and having a grey gold hue.

Abstract: A thin film resistor has a higher resistivity compared to that of a conventional thin film resistor. The thin film resistor includes 30-45 at % of nickel, 15-30 at % of chromium, 1-10 at % of manganese, 10-30 at % of yttrium and 1-20 at % of tantalum.

Abstract: Provided are: an alloy member that is excellent in homogeneity of both the alloy composition and microstructure and excellent in shape controllability and includes a high entropy alloy having high mechanical properties and high corrosion resistance, a process for producing the same, and a product including the alloy member. In the present invention, the alloy member having a chemical composition comprising elements of Co, Cr, Fe, Ni, and Ti each in an amount within a range of 5 atomic % or more and 35 atomic % or less and Mo in an amount within a range of more than 0 atomic % and 8 atomic % or less, the reminder consisting of unavoidable impurities, wherein ultrafine grains having an average grain diameter of 100 nm or less are dispersed and precipitated in a parent phase crystal.

Abstract: The invention relates to a steel for a tool holder. The steel comprises the following main components (in wt. %): C 0.07-0.13 Si 0.10-0.45 Mn 1.5-3.1 Cr 2.4-3.6 Ni 0.5-2.0 Mo 0.1-0.7 Al 0.001-0.06 S?0.003 The steel has a bainitic microstructure comprising up to 20 volume % retained austenite and up to 20 volume % martensite.

Abstract: The present invention provides a method for the fabrication of a steel sheet with a completely martensitic structure which has an average lath size of less than 1 micrometer and an average elongation factor of the laths is between 2 and 5. The elongation factor of a lath is defined as a maximum dimension lmax divided by and a minimum dimension lmin. The steel sheet has a yield stress greater than 1300 MPa and a mechanical strength greater than (3220(C)+958) megapascals. A composition of a semi-finished steel product includes, expressed in percent by weight, is, 0.15%?C?0.40%, 1.5%?Mn?3%, 0.005%?Si?2%, 0.005%?Al?0.1%, 1.8%?Cr?4%, 0%?Mo?2%, whereby: 2.7% 0.5 (Mn)+(Cr)+3(Mo)?5.7%, S?0.05%, P?0.1%, optionally: 0%?Nb?0.050%, 0.01%?Ti?0.1%, 0.0005%?B?0.005%, 0.0005%?Ca?0.005%. The semi-finished product is reheated to a temperature T1 in the range between 1050° C. and 1250° C., then subjected to a roughing rolling at a temperature T2 in the range between 1000 and 880° C.

Abstract: A steel sheet has a specific chemical composition and has a structure represented by, by area ratio, ferrite: 30 to 95%, and bainite: 5 to 70%. When a region that is surrounded by a grain boundary having a misorientation of 15° or more and has a circle-equivalent diameter of 0.3 ?m or more is defined as a crystal grain, the proportion of crystal grains each having an intragranular misorientation of 5 to 14° to all crystal grains is 20 to 100% by area ratio. An average aspect ratio of ellipses equivalent to the crystal grains is 5 or less. An average distribution density of the total of Ti-based carbides and Nb-based carbides each having a grain size of 20 nm or more on ferrite grain boundaries is 10 carbides/?m or less.

Abstract: Object of the invention is multi-phase steel, used for production of standard-gauge rails, characterized by the fact that the content of basic elements in the steel is no less than: C—0.15% wt, Si—0.60% wt, Mn—1.20% wt, Cr—1.20% wt, Ni—0.20% wt, Mo—0.10% wt, and additionally contains: Ti—0.01-0.25% wt, satisfying the relationship (% wt Mo)/(% mas. Ti)>1; Al—0.01-0.80% wt; B—0.001-0.003% wt., H2?2 ppm, N?80 ppm, volume of individual constituents is in relation to the total weigh of multiphase steel.

Abstract: The steel material according to the present invention contains, in mass %, C: 0.15 to 0.45%, Si: 0.10 to 1.0%, Mn: 0.10 to 0.8%, P: 0.050% or less, S: 0.010% or less, Al: 0.01 to 0.1%, N: 0.010% or less, Cr: 0.1 to 2.5%, Mo: 0.35 to 3.0%, Co: 0.05 to 2.0%, Ti: 0.003 to 0.040%, Nb: 0.003 to 0.050%, Cu: 0.01 to 0.50%, and Ni: 0.01 to 0.50%, and satisfies the following Formulae. A prior-austenite grain diameter of its microstructure is less than 5 ?m, and a block diameter of its microstructure is less than 2 ?m. The microstructure contains a total of 90% by volume or more of tempered martensite and tempered bainite. C+Mn/6+(Cr+Mo+V)/5+(Cu+Ni)/15?Co/6+??0.70??(1) (3C+Mo+3Co)/(3Mn+Cr)?1.

Abstract: A micro-alloyed manganese-boron steel includes about 0.25 to 0.4 wt. % carbon, about 0.5 to 2.7 wt. % manganese, about 0.001 to 0.005 wt. % boron, about 0.1 to 0.8 wt. % silicon, about 0.1 to 0.6 wt. % chromium, molybdenum and nickel, and about 0.01 to 0.06 wt. % aluminum, niobium and titanium. The balance is iron, and the steel is a micro-alloyed material for hot stamping of automotive parts.

Abstract: An air castable Fe-based stainless steel alloy comprises in weight % based on the total weight of the alloy 18-22% Cr, 15-22% Ni, 3-6% Al, 0.5-5% Mn, 0-3.5% W, 0-5% Cu, 0-2% Si, 1-2.5% Nb, 0.3-0.5% C balance Fe wherein, Cu+W+Si=0.5-10.5, and the alloy provides an oxidation resistance of 0.5<specific mass change <+2 mg/cm2 after 400 one hour cycles at 900° C. in 10% water vapor.

Abstract: A steel plate according to an aspect of the present invention has a predetermined chemical composition, an index Q obtained by Equation (1) is 0.00 or more, a carbon equivalent Ceq (%) obtained by Equation (2) is less than 0.800%, a ratio of a difference between a hardness at a surface layer portion and a hardness at a thickness center portion to the hardness at the surface layer portion at a room temperature is 15.0% or less, the hardness at the suffice layer portion at a room temperature is 400 or more in terms of Vickers hardness, and a steel thickness is 40 or more. Q=0.18?1.3(logT)+0.75(2.7×[C]+[Mn]+0.45×[Ni]+0.

Abstract: A high-strength steel sheet having a TS of 780 MPa or more, excellent stretch flangeability, and excellent in-plane anisotropy of TS is provided. A high-strength steel sheet comprises: a predetermined chemical composition; a steel microstructure including, in area fraction, ferrite: 20% or more and 50% or less, lower bainite: 5% or more and 40% or less, martensite: 1% or more and 20% or less, and tempered martensite: 20% or less, and including, in volume fraction, retained austenite: 5% or more, the retained austenite having an average grain size of 2 ?m or less; and a texture having an inverse intensity ratio of ?-fiber to ?-fiber of 3.0 or less.

Abstract: The invention relates to a duplex stainless steel composition, the composition of which consists of, in % by weight: C?0.05% 21%?Cr?25% 1%?Ni?2.95% 0.16%?N?0.28% Mn?2.0% Mo+W/2?0.50% Mo?0.45% W?0.15% Si?1.4% Al?0.05% 0.11%?Cu?0.50% S?0.010% P?0.040% Co?0.5% REM?0.1% V?0.5% Ti?0.1% Nb?0.3% Mg?0.1% the balance being iron and impurities resulting from the smelting, and the microstructure consisting of austenite and 35 to 65% ferrite by volume, the composition furthermore satisfying the following relationships: 40?IF?70 where IF=6×(% Cr+1.32×% Mo+1.27×% Si)?10×(% Ni+24×% C+16.15×% N+0.5×% Cu+0.4×% Mn)?6.17 and ILCR?30.5 where ILCR=% Cr+3.3×% Mo+16×% N+2.6×% Ni?0.7×% Mn, and also to a process for manufacturing plate, strip, coil, bar, rod, wire, sections, forgings and castings made of this steel.