Abstract: Provided according to embodiments of the invention are systems for monitoring a physiological state of an individual that include a PPG sensor, which optionally includes an auxiliary physiological sensor integrated with or connected thereto; a first signal processing device in electronic communication with the PPG sensor, whereby the PPG sensor transmits PPG signals to the first signal processing device; and a second signal processing device that detects at least a portion of the signals transmitted by the PPG sensor to the first signal processing device, at least a portion of signals transmitted by the auxiliary physiological sensor, or both. Related methods are also provided herein.

Abstract: Optical-electronic device configured to generate a calibration factor for use in determining optical density. The device includes at least one emitter configured to emit light, a detector configured to receive light and transmit data representative of the received light and a processor coupled to the at least one emitter and the detector. The device further includes a non-transitory storage medium coupled to the processor and configured to store instruction to cause the device to perform the calibration method. Additionally, a calibration container includes a main body, upper lid, and a lower lid. The main body is configured to receive the device and an object having known optical properties.

Abstract: A biometric sensor arrangement (10) comprises a first radiation source (11), a second radiation source (12) that is implemented as a flash radiation source and a driver (13) coupled to the first and the second radiation source (11, 12) and configured to selectively operate the first and the second radiation source (11, 12). Moreover, the biometric sensor arrangement (10) comprises a photosensor (16) and a signal conditioning unit (18) coupled to the photosensor (16) and designed to provide a biometric signal (SB).

Abstract: An embodiment of the present disclosure provides a noninvasive optical sensor or probe including disposable and reusable components. The assembly of the disposable and reusable components is straightforward, along with the disassembly thereof. During application to a measurement site, the assembled sensor is advantageously secured together while the componentry is advantageously properly positioned.

Abstract: Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods.

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

Abstract: A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

Abstract: This disclosure relates to a device to mechanically and electrically connect with a touch screen computing device, such as a tablet computer. The device can include a platform that can be moved into and out of physical contact with a surface of a touch screen. During engagement with the surface, the moveable platform electrically interacts with the touch screen (e.g., via capacitive coupling) to enable detection by the touch screen of contact members (e.g., pegs) even in the absence of user contact with the pegs.

Abstract: A system includes a photodetector array and a processor. The photodetector array includes a plurality of photodetectors and is configured to detect light that exits a body and output a plurality of electronic signals representative of the detected light as a function of time. The processor is configured to sample the electronic signals output by the photodetector array at a plurality of delay times during a predetermined time period to generate a sequence of frames, apply a plurality of temporal-based and spatial-based correlation measurement operations to sample values in each of the frames, generate, based on the application of the temporal-based and spatial-based correlation measurement operations to the sample values in each of the frames, a plurality of spatiotemporal correlation measure values for the light detected by the photodetector array, and include the plurality of spatiotemporal correlation measure values in a correlation map.

Abstract: A system and method for detecting and analyzing the characteristics of seizures, such as tonic-clonic seizures, comprising at least one processor unit capable of recording a signal from a sensor unit, one or more analysis modules configured to analyze the recorded signal, one or more evaluation modules configured to evaluate the output signals from the analysis modules. A first analysis module is configured to analyze the recorded signal within a first frequency band, and a second analysis module is configured to analyze the recorded signal within a second frequency band, and the evaluation module is configured to calculate the ratio between the two output signals from the analysis modules. The system includes a seizure detection module configured to detect a seizure and a time-point extraction module configured to determine at least one starting point and an end point of the seizure.

Abstract: A hand held imaging device for measuring characteristics of hair and scalp, comprising a housing with a high magnification optic for obtaining magnified images of surface characteristics of hair fibers, said high magnification optic comprising a first lens and a first light source, and a low magnification optic for obtaining magnified images of the scalp and hair, said low magnification optic comprising a second lens and a second light source, wherein the high magnification optic has a fixed focal length and a slot for locating hair fibers in frame such that the hair fibers are in focus and wherein the device further comprises a viewing means, selected from an integral viewing means, an external viewing means and a combination thereof.

Abstract: A sleep monitoring system (10) for monitoring the sleep of a subject is disclosed. The system comprises a CO2 sensor (21) and a processor (31) communicatively coupled to the CO2 sensor, wherein the processor is adapted to monitor a CO2 concentration from sensor data produced by the CO2 sensor; and derive sleep pattern information from the monitored CO2 concentration, wherein the sleep pattern information comprises at least an indication that the subject is awake and an indication that the subject is asleep. A sleep monitoring method and computer program product are also disclosed.

Abstract: Embodiments of the invention are directed to a computer-implemented method for generating a sleep optimization plan. A non-limiting example of the computer-implemented method includes receiving, by a processor, genetic data for a user. The method also includes receiving, by the processor, Internet of Things (IoT) device data for the user. The method also includes generating, by the processor, a sleep duration measurement for the user based at last in part upon the IoT device data. The method also includes generating, by the processor, a sleep optimization plan for the user based at least in part upon the genetic data.

Abstract: A method of measuring efficacy of treatment of multiple sclerosis (MS) in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. This dataset is compared to healthy animals or a standard of care to determine efficacy. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Another embodiment uses a Fourier transform on a circle and a linear combination. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals.

Abstract: A wearable device measures heart rate recovery of a user in a non-clinical setting. The wearable device comprises a heart rate detector configured to detect heart rate data of the user, an activity sensor configured to detect motion of the user, and a processor. The processor is configured to identify a start of an activity by the user using the motion detected by the activity sensor. Responsive to detecting the start of the activity, the processor monitors the motion detected by the activity sensor to identify an end of the activity. A regression analysis is performed on heart rate data detected by the heart rate detector during a period of time after the end of the activity, and the heart rate recovery of the user is determined using the regression analysis.

Abstract: An apparatus for measuring patient data includes a frame having a plurality of electrode hubs. Each hub can include one or more electrode members. The frame can be configured to receive a head of a patient. Each of the electrode hubs can have a single electrode member or a plurality of electrode members that extend from or are connected to an outer member for contacting a scalp of the head of the patient. The outer member can have at least one circuit configured to transmit data received by at least one of the electrode members to a measurement device via a wireless communication connection (e.g. Bluetooth, near field communication, etc.) or a wired communication connection.

Abstract: A modular intelligent clothing is provided, which includes a clothing body, modular main board, and a functional board, in which the modular main board is disposed at any position of the clothing body, the functional board is disposed at any position of the clothing body, and the functional board is electrically coupled with the modular main board. The electrically connection between the functional board and the modular main board utilize the metal conductor, magnetic induction, or wireless communication. Accordingly, the functional board and the modular main board are matched each other to sense the physiological signals of the user, to position of the location of user, or to perform the home care monitoring.

Abstract: A personal impact monitoring system is described herein comprising a monitoring station that receives impact events sent from personal impact monitors, using a monitoring station receiver. The impact events, which specify impact parameters associated with the impact events, are stored in a data storage location associated with the monitoring station. Software operating on the operating station is configured to retrieve the impact events from the data storage location and to perform calculations based on the impact events to identify notable impact events.

Abstract: This disclosure generally relates to medical devices that include a sensor transmitter assembly that includes a sensor assembly including a sensor module where a first sensor including a first sensor head having at least one first sensor contact pad is combined with a second sensor including a second sensor head having at least one second sensor contact pad. The sensor transmitter assembly also includes a transmitter assembly positioned on a top of the sensor assembly to form a single unit, the transmitter assembly having at least one transmitter contact disposed on a base of the transmitter assembly, where the first sensor contact pad(s) and the second sensor form a connection path with the transmitter contact(s).

Abstract: Various embodiments of a sealed package and a method of forming such package are disclosed. The package can include a non-conductive substrate that includes a cavity disposed in a first major surface. A cover layer can be disposed over the cavity and attached to the first major surface of the non-conductive substrate to form a sealed enclosure. The sealed package can also include a feedthrough that includes a via between a recessed surface of the cavity and a second major surface of the substrate, and a conductive material disposed in the via. An external contact can be disposed over the via on the second major surface of the non-conductive substrate, where the external contact is electrically connected to the conductive material disposed in the via. The sealed package can also include an electronic device disposed within the sealed enclosure that is electrically connected to the external contact.

Abstract: An MRI system for imaging a moving subject is provided. The MRI system includes a magnet assembly and an MRI controller. The magnet assembly is configured to acquire a k-space via scanning the subject. The acquired k-space includes a plurality of datum each having a motion error. The MRI controller is configured to receive the acquired k-space from the magnet assembly. The MRI controller is further configured to suppress the motion error of each datum by reconstructing the k-space via a soft gating threshold in a non-iterative manner.

Abstract: The disclosure relates to systems and methods for acquisition of biosignals with motion sensor-based artifact compensation. One example embodiment is a system for acquisition of biosignals from a subject. The system includes at least one biosensor worn over a first location of a body part of the subject configured for biosignal measurement and providing a measured biosignal. The system also includes a plurality of inertial motion sensors worn over a plurality of locations of the body part of the subject. Each of the inertial motion sensors is configured for providing a motion vector signal. The system further includes a biosignal adaptation unit configured for receiving and adapting the measured biosignal. In addition, the system includes a motion estimation unit. Further, the system includes a digital filter unit. At least one of the plurality of inertial motion sensors is mechanically connected to the at least one biosensor.

Abstract: In a method for computing MR images of an examination object that performs a cyclic movement, MR signals are detected over at least two cycles of the cyclic movement. In each of these cycles, data for multiple MR images are recorded. Over these cycles, a magnetization of the examination object that influences the MR images approaches a state of equilibrium in a second of these cycles is closer to the state of equilibrium than in a first of these cycles. Movement information for various movement phases of the cyclic movement of the examination object is determined using the MR images from the second cycle, with movement information of the examination object determined for each of the various movement phases. Movement correction of the examination object is carried out in the MR images of the first cycle using the movement information determined in the second cycle.

Abstract: The present invention is configured to compare an output result of frequency analysis of a frequency gradient time-series waveform of a biosignal with preset corresponding data of output results of brain waves of different biological states to the output result. Accordingly, it is possible to estimate a time-series variation of a biological state which is specified by a brain wave state and brain waves by using a biological index other than brain waves, in particular, a result of frequency analysis of a frequency gradient time-series waveform of a biosignal reflecting an autonomic nervous function. Using an electroencephalograph is not required, and thus it is possible to estimate brain waves and a biological state corresponding to brain waves easily and rapidly.

Abstract: Detecting chronotropic incompetence includes determining, using a processor, a baseline cardiac health measure for a user based upon an estimate of activity level for the user, validating, using the processor, the estimate of activity level for the user with a validation factor determined from sensor data and determining, using the processor, a cardiac health measure for the user from the sensor data. A signal indicating chronotropic incompetence for the user can be provided by the processor based upon a comparison of the cardiac health measure for the user with the baseline cardiac health measure.

Abstract: A method and system for acquiring data for assessment of cardiovascular disease, the method comprising one or more of: manipulating one or more hardware aspects of the photoplethysmography data acquisition system(s) implementing the method; manipulating or providing user experience/user interface (UX/UI) aspects of the system(s) implementing the method; acquiring, processing, and deriving insights population specific data; accounting for or controlling sampling site variability; and using other suitable sources of data in order to generate high quality data for characterization, assessment, and management of cardiovascular disease.

Abstract: A method for determining a respiration rate of a subject, includes receiving a first signal and a second signal, each signal being representative of a physiological parameter of the subject. The method includes removing a cardiac artifact signal from the first signal and the second signal to generate a first processed signal and a second processed signal respectively. The method includes removing a motion artifact signal from the first processed signal and the second processed signal to generate a first periodic signal and the second processed signal respectively. The method further includes removing a residual noise signal from the first periodic signal and the second periodic signal to generate a first noise free signal and the second noise free signal respectively. The method includes generating a combined value from a first value and a second value based on the first noise free signal and the second noise free signal respectively.

Abstract: The present invention includes a healthcare system for capturing and maintaining patient healthcare records and employing information in the records to proactively alert hospital workers to a condition that places patient health at risk.

Abstract: According to one embodiment, an X-ray computed tomography imaging apparatus includes an X-ray tube, an X-ray detector, and control circuitry. The X-ray tube includes a cathode configured to generate thermoelectrons, an anode configured to generate X-rays upon receiving the thermoelectrons from the cathode, and a regulator configured to apply an electric field or a magnetic field to focus or bias the thermoelectrons from the cathode. The X-ray detector detects the X-rays generated by the anode. The control circuitry controls the regulator to switch at least one of the size and position of the focus of the thermoelectrons from the cathode on the anode between scan and warm-up.

Abstract: The invention relates to a computed tomography system (30). Several sets of spectral projections, which correspond to different positions of a radiation source (2) along a rotation axis (R), are decomposed into first projections being indicative of a contrast agent and second projections being not indicative of the contrast agent. An image is generated by a) determining for each first projection a contrast value being indicative of a total amount of contrast agent and scaling the first projections such that for different first projections of a same set the same contrast value is determined, and reconstructing an image based on the scaled first projections, and/or b) reconstructing for the different sets first images, scaling the first images such that they have a same intensity in overlap regions and combining the scaled first images. Thus, different contrast agent amounts can be balanced, thereby allowing for an improved image quality.

Abstract: An X-ray imaging apparatus is provided.

Abstract: The grating device (1) for an X-ray imaging device comprises a grating arrangement (10) and an actuation arrangement (20). The grating arrangement (10) comprises a plurality of grating segments (11). The actuation arrangement (20) is configured to move the plurality of grating segments (11) with at least a rotational component between a first position and a second position. In the first position, the grating segments (11) are arranged in the path of an X-ray beam (30), so that the grating segments (11) influence portions of the X-ray beam (30). In the second position, the grating segments (11) are arranged outside the portions of the path of an X-ray beam (30), so that the portions of the X-ray beam (30) are unaffected by the grating segments (11).

Abstract: An X-ray imaging method is for generating contrast-enhanced image data relating to an examination region of an object to be examined. In an embodiment of the method, first contrast-agent influenced measured X-ray projection data with a first X-ray energy spectrum and at least one set of second contrast-agent influenced measured X-ray projection data with a second X-ray energy spectrum are acquired from the examination region. Subsequently, image data assigned to a third X-ray energy spectrum with a third mean energy, based on the first and at least second measured X-ray projection data is reconstructed based on the first and at least second measured X-ray projection data that has been acquired. A mean energy of the first X-ray energy spectrum and a mean energy of the second X-ray energy spectrum are selected as a function of a dimension parameter value of the object that is to be examined.

Abstract: Provided are methods for characterizing a feature of interest in a digital image. In certain aspects, the methods use an adaptive local window and include obtaining an initial contour for a feature of interest, defining a region of interest around the contour, and segmenting the feature of interest by iteratively selecting a size of a local window surrounding each point on the contour. Non-transitory computer readable media and systems that find use in practicing the methods of the present disclosure are also provided.

Abstract: A stitch imaging system, which uses a plurality of radiographic imaging units, includes an information acquisition unit configured to acquire information indicating a layout relationship among the plurality of radiographic imaging units, and a correction unit configured to correct a radiographic image or radiographic images acquired from at least one of the plurality of radiographic imaging units specified based on the information indicating the layout relationship, based on correction data specified based on the information indicating the layout relationship.

Abstract: An extra-oral imaging apparatus is intended to obtain a cephalometric image of a portion of a head of a patient. Exemplary apparatus embodiments of cephalometric functionality of such extra-oral imaging apparatus can include a cephalometric support mounted to a base of the imaging system that is configured to position a cephalometric sensor about a cephalometric imaging area so that x-rays impinge the cephalometric sensor after radiating the cephalometric imaging area. A cephalometric collimator can be mounted to a patient positioning unit to provide secondary collimation of the x-ray beam for the cephalometric sensor. Exemplary apparatus and/or method embodiments of the application relates to providing a measurable indication of alignment between a cephalometric collimator and cephalometric sensor or the extra-oral imaging apparatus, which can provide a repeatable and/or accurate alignment between a cephalometric collimator and cephalometric sensor.

Abstract: A method for optimizing CT scanning parameter is disclosed. A target group may be generated from a plurality of reference information samples. Each of the reference information samples may include subject information, information indicating a scanning protocol, one or more scanning parameter values and information indicating reconstructed image quality; the target group can consist of one or more reference information samples with the same subject information and the same scanning protocol. A scanning parameter optimization may be performed according to reconstructed image qualities and scanning parameter values of reference information samples in the target group, so as to acquire a target scanning parameter value of the target group. And according to the target scanning parameter value, a reference X-ray irradiation dose corresponding to the scanning protocol and the subject information of the target group may be determined.

Abstract: System and method for determining a heart rate and a heart rate variability of an individual is disclosed. An audio signal of heart sound is amplified. Subsequently, an envelope of the amplified audio signal is detected by squaring of the amplified audio signal to obtain emphasized high amplitude components and diminished low amplitude components of the audio signal, applying a band pass filter on the audio signal upon squaring and applying a Teager-Kaiser Energy Operator (TKEO) on the filtered audio signal. Peaks in the envelope of the audio signal are detected by calculating difference in magnitude of a point in the audio signal with an average of magnitude of earlier points in the audio signal from the last detected peak or the initial sample value in the processing window when no peak is detected. Based on the peaks detected, heart rate and heart rate variability for the individual are determined.

Abstract: Disclosed is a method and device for detecting a viscoelastic parameter of a viscoelastic medium. The method comprises: applying a mechanical vibration at a single predetermined frequency to the viscoelastic medium to generate a shear wave in the viscoelastic medium (101); emitting ultrasonic waves to the viscoelastic medium, and receiving ultrasonic echo signals (102); acquiring maximum displacement data of the shear wave at various depths according to the ultrasonic echo signals (103), each of the maximum displacement data representing a maximum oscillation amplitude of the shear wave when the shear wave propagates to different depths in the viscoelastic medium; fitting each of the maximum displacement data to obtain a maximum displacement attenuation curve (104); and determining the viscoelastic parameter of the viscoelastic medium according to the maximum displacement attenuation curve (105). The method and device can provide a more accurate measurement result of tissue fibrosis.

Abstract: An arrhythmia detection device is provided, which includes: a monitoring probe attached to a subject to be examined; a monitoring unit coupled with the monitoring probe; a first displaying unit which displays ECG parameters obtained by the monitoring unit; an ultrasound probe attached onto a body surface of the subject; an ultrasound imaging unit coupled with the ultrasound probe; an arrhythmia triggering unit which triggers the ultrasound imaging unit to scan the heart of the subject when the monitoring unit detects an arrhythmia; and a second displaying unit which displays the images and/or the parameters of the heart obtained by the ultrasound imaging unit.

Abstract: The invention generally relates to intravascular imaging system and particularly to processing in multimodal systems. The invention provides an imaging system that splits incoming image data into two signals and performs the same processing step on each of the split signals. The system can then send the two signals down two processing pathways. Methods include receiving an analog image signal, transmitting the received signal to a processing system, splitting the signal to produce a first image signal and a second image signal, and performing a processing operation on the first image signal and the second image signal. The first and second signal include substantially the same information as one another.

Abstract: A field programmable gate array (FPGA) circuit including a quadrature internal conditioning circuit is provided. The circuit having a buffer circuit; and a reconstruction engine circuit, wherein the reconstruction engine circuit includes: a circuit to measure a phase of a signal; and a flavor interpolation circuit; wherein: the circuit to measure the phase of a signal includes digitization points forming two complex numbers for each cycle of the center frequency of the signal. A system for collecting tissue images including a patient interface module (PIM); a pulse transmitter circuit; an analog to digital converter circuit; and an FPGA circuit as above; and a catheter having a sensing head is also provided. A method for using the above system to provide an image reconstruction is also provided.

Abstract: A data processing method for calculating the contact position of a medical ultrasound transceiver on the head of a patient, comprising the steps of: a) acquiring ROI data which represent a region of interest (ROI) corresponding to at least a part of a vessel in a vascular structure; b) acquiring contact region data which represent a contact region for the ultrasound transceiver on the head, wherein the contact region corresponds to one or more acoustic windows; c) determining at least one target point in the region of interest; d) determining at least two entry points on the contact region; e) calculating a set of lines which comprises the lines between the two points of each respective possible pair consisting of one entry point and one target point; f) eliminating lines which pass through a bony structure other than the bone immediately beneath the contact region; g) calculating a score for each of the remaining lines; and h) selecting the entry point of the line with the highest score as the contact positi

Abstract: An ultrasound diagnosis apparatus for emitting ultrasound waves to an examination object and obtaining an ultrasound image is provided. The apparatus includes a touch display configured to display a screen that includes the ultrasound image, and a controller configured to receive a touch input associated with the ultrasound image, and set a focus or depth of the ultrasound image to be displayed based on a touched position.

Abstract: According to one embodiment, an ultrasonic diagnostic device includes a first rendering unit, a second rendering unit, a superimposition processing unit, a display control unit. The first rendering unit generates a first rendering image according to a first rendering method based on volume data collected by three-dimensionally scanning a subject with ultrasonic waves. The second rendering unit generates a second rendering image according to a second rendering method that is different from the first rendering method, based on the volume data. The superimposition processing unit generates a superimposed image in which at least a part of the first rendering image and a part of the second rendering image are superimposed on each other. The display control unit causes a display device to display the superimposed image. The superimposition processing unit adjusts a superimposition ratio of the first and second rendering images in the superimposed image.

Abstract: An assisted detection system of breast tumor includes an image capturing unit and a non-transitory machine readable medium. The non-transitory machine readable medium storing a program which, when executed by at least one processing unit, determines a breast tumor type of the subject and predicts a probability of a tumor location of the subject. The program includes a reference database obtaining module, a first image preprocessing module, an autoencoder module, a classifying module, a second image preprocessing module and a comparing module.

Abstract: A software-based ultrasound imaging system is disclosed. According to some embodiments of the present disclosure, a method and an architecture for efficiently transmitting, processing, and storing channel data in the software-based ultrasound imaging system are provided.

Abstract: Steerable medical devices and methods of use. In some embodiments, the steerable medical devices include a steerable portion with a stiffness that varies along the length of the steerable portion.

Abstract: An illuminated surgical retractor embodiment includes a blade, a handle, a curved section and an illumination assembly. The blade has a top surface and a bottom surface. The handle extends at an angle from a proximal end of the blade. The curved section connects the handle to the blade. The illumination assembly includes at least one light source, at least one battery and an activation device for energizing the light source. In an embodiment, the blade, handle, and curved section are molded from a glass-fiber reinforced polymer.

Abstract: Embodiments of claimed subject matter are directed to a malleable and integrally illuminated surgical retractor. In an embodiment, a malleable steel strip, having a thickness approximately in the range of 0.5-1.0 mm, may form a substrate. An elastically deformable layer, such as a polymeric layer, may be secured to the malleable steel strip. One or more meandering conductive lines, spiral conductors, or conductive inks, which may elongate and/or compress during bending of the substrate, may be secured to the TPU layer. The one or more meandering conductive lines, spiral conductors, or conductive inks may operate to couple current from an electronics module to one or more malleable illumination sources comprising, for example, an organic light-emitting diode (OLED).