Patents Issued in September 24, 2019
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Patent number: 10420692Abstract: A surgical support system provides a set of paddles receivable by a pegboard to provide larger area skin-supporting surfaces as stabilized by a pair of pegs received in the pegboard. The paddles may be primarily constructed of an autoclavable radiolucent polymer with short aluminum pegs in their lower ends for being received in the pegboard.Type: GrantFiled: November 17, 2016Date of Patent: September 24, 2019Assignee: Match Grade Medical LLCInventors: David M. Kettner, Robert P. Limoni
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Patent number: 10420693Abstract: An actuator delivers mechanical vibrations to the body of a subject. The actuator includes a piezoelectric element, electrodes in electrical communication with an electrical source and the piezoelectric element to drive the piezoelectric element, a polymeric protective layer encapsulating the piezoelectric element and part of the electrodes, and an enclosure attached to the protective layer. The actuator includes a space between the protective layer and the enclosure allowing desired modes of vibration to develop across a surface of the protective layer that encapsulated the piezoelectric element. The actuator can include a skin attachment article that has a mounting pad for attaching to the skin of the subject and for attaching the actuator. The skin attachment article has a cover that overlies the actuator and the mounting pad when the article is attached to the skin of the subject.Type: GrantFiled: February 22, 2012Date of Patent: September 24, 2019Assignee: Perfuzia Medical, Inc.Inventors: Shai Y. Schubert, Sagi Brink-Danan
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Patent number: 10420694Abstract: An item of clothing is adapted to be worn against the skin, and comprises at least one panel adapted to provide targeted compression of at least 20% of the total length of a specific surface vein in the body, or adapted to provide targeted compression of at least 20% of a specific plexus of veins, a specific lymphatic plexus, drainage plexus or a collection of lymphatic vessels. The clothing is useful in a method of reducing recovery time in a human or other mammal, after a period of activity and in a method of enhancing performance, in particular sports performance, in a human or other mammal. It may also improve the conditioning of the skin and aid lymphatic drainage, and can be used in the treatment of certain medical conditions.Type: GrantFiled: July 21, 2015Date of Patent: September 24, 2019Assignee: Anatomic Focus LimitedInventor: Stephen George Edward Barker
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Patent number: 10420695Abstract: An exoskeleton apparatus driven by a pneumatic artificial muscle with functions of upper limb assist and rehabilitation training includes an upper limb frame, a shoulder joint mechanism, and an elbow joint mechanism which are driven by utilizing a processing unit, a first angle sensing unit, a second angle sensing unit, a first proportional pressure valve, a pressure sensing unit and a pneumatic muscle device. The exoskeleton apparatus can be independently used as an upper limb exoskeleton assistive device or can be combined to form an upper limb exoskeleton rehabilitation training system to simulate the upper limb movements in daily life through the upper limb frame to assist with the movements of the wearer's upper limbs, accomplishing the rehabilitation training of each upper and lower arm joint and neurological function.Type: GrantFiled: April 12, 2017Date of Patent: September 24, 2019Assignee: Lunghwa University of Science and TechnologyInventor: Lian-Wang Lee
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Patent number: 10420696Abstract: A walking assistance method may include: detecting a landing time of a foot of a user; and/or initiating gait assistance based on a first joint location of a first leg of the user sensed at the landing time and a second joint location of the user sensed after the landing time. A walking assistance apparatus may include: a driver configured to perform gait assistance of a user; and/or a controller configured to control the driver to initiate the gait assistance based on a first joint location of a first leg of the user sensed at a landing time of a foot of the user and a second joint location sensed after the landing time.Type: GrantFiled: December 29, 2015Date of Patent: September 24, 2019Assignee: Samsung Electronics Co., Ltd.Inventors: Jun-Won Jang, Kyung-Rock Kim, Youngbo Shim, Jusuk Lee, Bokman Lim
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Patent number: 10420697Abstract: A device for assisting navigation including a body defining a middle portion having a first end and a second end, a handle portion at one of the first or second ends, a holder that is removably mounted with another end of the first or second ends of the body.Type: GrantFiled: December 19, 2014Date of Patent: September 24, 2019Assignee: HONG KONG R&D CENTRE FOR LOGISTICS AND SUPPLY CHAIInventors: Hailong Zhu, Feng Lu, Guangbo Li, Xiaosheng Chen, Chilun Mak, Jiankun Su, Tingwen Xiong
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Patent number: 10420698Abstract: A head massaging cap device for massaging the head includes a shell that is cap shaped. The shell has an inner layer and an outer layer. A compartment is coupled to a front of the shell. A power module is coupled to and positioned in the compartment. A solid state music player is coupled to and positioned in the compartment. A plurality of cooling zones and plurality of heating zones are positioned in the outer layer. A plurality of tracks is positioned on and coupled to an interior surface of the inner layer. The tracks comprise rack gears. Each of a plurality of massage probes is coupled to a respective one of the tracks.Type: GrantFiled: November 13, 2015Date of Patent: September 24, 2019Inventors: William Jones, Jr., Lisa Simmons-Jones
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Patent number: 10420699Abstract: A controller is operable to selectively supply gas to, and evacuate gas from, regions of a hyperbaric wound treatment chamber. The controller operates to inflate a passage or rib of the device to provide that the device is made sufficiently rigid for inserting a limb therethrough, and inflate an inflatable cuff to create a seal against the limb. The controller also operates to evacuate ambient air trapped within the chamber, and optionally partially evacuate the passage or rib, after the seal is created by the inflatable cuff, and then introduce oxygen into the chamber, and optionally inflate the passage or rib. The cuff, when inflated and creating a seal against a limb, optionally is at least partially within the chamber, and the treatment gas is supplied to the chamber to maintain the seal of the cuff against the limb.Type: GrantFiled: August 16, 2013Date of Patent: September 24, 2019Assignee: AOTI, Inc.Inventors: Phillip Loori, George Hovorka
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Patent number: 10420700Abstract: An interchangeable intimate accessory system including a first phallic device having a distal end and a proximal end, the distal end of the first phallic device being shaped for sexual application to a human orifice and the proximal end of the first phallic device being formed as a first connector; a second phallic device having a distal end and a proximal end, the distal end of the second phallic device being shaped and configured for sexual application to a human orifice and the proximal end of the second phallic device being formed as a second connector. The first and second phallic devices are removeably couplable to one another, via the first and second connectors, to provide a dual-ended configuration when coupled together and an individual-use configuration when not coupled together.Type: GrantFiled: February 2, 2017Date of Patent: September 24, 2019Inventors: Maya Green, Lindsay Lewis
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Patent number: 10420701Abstract: A system includes a processor coupled to a memory. The processor and memory are configured to receive, from one or more cameras, multiple images of a victim undergoing a resuscitation event at a rescue scene; generate a representation of the rescue scene based on the received images; and determine a characteristic associated with the resuscitation event based on an analysis of the of the rescue scene.Type: GrantFiled: November 8, 2013Date of Patent: September 24, 2019Assignee: ZOLL MEDICAL CORPORATIONInventor: Gary A. Freeman
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Patent number: 10420702Abstract: Devices, systems, software and methods for CPR quality assessment. Patient data is received, derived from a session of administering sets of CPR chest compressions to a patient. The sets can be separated by pauses. In some embodiments, a penalty value can be determined for at least one of the pauses, from at least one control factor unrelated to a constant linear dependence on the pause duration. An indicative value can be derived from the penalty value. In some embodiments, at least some of the pauses are classified in one or more pause groups, depending on how well they meet one or more classification criteria. The indicative value can be derived for one of the pause groups. The indicative value can be output, and/or an alarm can be emitted if it exceeds a threshold. CPR quality assessment can be improved in real time, and provide feedback for training.Type: GrantFiled: February 18, 2014Date of Patent: September 24, 2019Assignee: PHYSIO-CONTROL, INC.Inventors: Robert G. Walker, Ronald E. Stickney, Fred W. Chapman
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Patent number: 10420703Abstract: A pill container has a body, multiple lids, and multiple resilient pushing bars. The body has a front wall, a rear wall, multiple compartments, and multiple locking buttons. The locking button are formed on the front wall of the body and aligned respectively with the compartments. The lids are connected pivotally to the rear wall of the body to selectively close the compartments respectively and are engaged detachably with the locking buttons respectively. Each lid has an inner surface facing a corresponding one of the compartments of the body. The resilient pushing bars are mounted on the rear wall of the body and respectively abut against the inner surfaces of the lids.Type: GrantFiled: September 20, 2018Date of Patent: September 24, 2019Assignee: E-LINK PLASTIC & METAL INDUSTRIAL CO., LTD.Inventor: Cheng-Hua Lee
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Patent number: 10420704Abstract: A PTP sheet for pharmaceutical packaging has a first sheet in which pockets each capable of housing a solid pharmaceutical are projected to the side of a first surface which is one of a back surface and a front surface and a second sheet which is pasted to a second surface opposite to the first surface in the first sheet and covers an opening of the pocket. The second sheet has a first region having mesh-shaped grooves having a first depth in a third surface opposite to the surface to be pasted to the second surface and a second region having mesh-shaped grooves having a second depth smaller than the first depth or not having a groove.Type: GrantFiled: June 12, 2014Date of Patent: September 24, 2019Assignee: Nipro CorporationInventors: Kazuaki Uetake, Takeshi Kodai
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Patent number: 10420705Abstract: The present disclosure relates to a container assembly for use in a planetary mixer, which may comprise a jar with an inner wall, an adapter in contact with the inner wall of the jar, a metered-dosage dispenser having a tubular body, and a lid attachable to an rim of the jar, wherein the adapter, if included, may be configured to clamp to the metered-dosage dispenser, if included, and the adapter, if included, may be further configured to keep the metered-dosage dispenser away from the inner wall of the jar, wherein at least a portion of the metered-dosage dispenser, if included, may be configured to allow visibility of at least some contents inside the body of the metered-dosage dispenser from outside the body of the metered-dosage dispenser, and wherein the body of the metered-dosage dispenser, if included, may have a height-to-base ratio (HBR) between 0.75 and 1.5 at half volume.Type: GrantFiled: September 14, 2018Date of Patent: September 24, 2019Assignee: MEDISCA PHARMACEUTIQUE INC.Inventors: Panagiota Danopoulos, Vargha Talebi
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Patent number: 10420706Abstract: A safe tablet cutting device includes a container, a cover, a cutter, and a suspension body. A platform in the container provides tablet positioning. First and second positioning elements are configured between a back end of the container and the platform. The cover is hinged to the back end of the container. The suspension body has its back end freely rotatable but confined between the first and second positioning elements when the cover is opened or closed. The suspension body has a slot opening corresponding to the cutter configured on the inside of the cover so that the cutter is properly concealed behind the suspension body and, when the cover is closed, gradually exposed to cut the tablet. The safety and applicability of the tablet cutting device is as such enhanced.Type: GrantFiled: July 29, 2018Date of Patent: September 24, 2019Assignee: E-LINK PLASTIC & METAL INDUSTRIAL CO., LTD.Inventor: Chih-Chun Lee
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Patent number: 10420707Abstract: Disclosed is a portable medication dispenser. The portable medication dispenser includes a housing comprising multiple compartments, wherein each compartment is configured to accommodate one or more medications, wherein the housing is constructed with a tamper-proof material. Further, the portable medication dispenser includes multiple latches corresponding to the multiple compartments. Yet further, the portable medication dispenser includes one or more actuators configured to engage with one or more latches of the multiple latches. Yet further, the portable medication dispenser includes a controller electrically coupled to the one or more actuators. Moreover, the portable medication dispenser includes a communication interface coupled to the controller, wherein the communication interface is configured to receive one or more commands associated with activating the one or more actuators.Type: GrantFiled: May 11, 2017Date of Patent: September 24, 2019Inventor: Victor Lewis
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Patent number: 10420708Abstract: A medication management system, having a means for recording a medication regimen; and a medication dispenser having: a base having a sensor for detecting changes in the medication dispenser; a casing having: compartments; walls separating each compartment; and wires housed within the walls; a cap adapted to fit onto and rotate on the top end, the cap having: a door adapted to be in a closed state and in an open state; a first cap magnet; and a second cap magnet adapted to be aligned with and make a magnetic connection with the first cap magnet when the door is in the open state, creating a first electrical signal; wherein the first electrical signal is sent to the processor via the wires; such that a removal of the medication from the medication dispenser is detected by the sensor and generates a second electrical signal sent to the processor.Type: GrantFiled: March 27, 2019Date of Patent: September 24, 2019Inventors: James Arric, Akira Mu
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Patent number: 10420709Abstract: An enteral dosing control coupling comprising a cylindrical collar defining a hollow internal chamber and a lumen extension tip projecting axially into the internal chamber, the lumen extension tip defining an internal lumen extending therethrough. In example forms, the lumen extension tip is integrally formed with the cylindrical collar. In other example forms, the lumen extension tip is a separate piece and is removably engageable within the cylindrical collar.Type: GrantFiled: July 14, 2016Date of Patent: September 24, 2019Assignee: NeoMed, Inc.Inventors: Benjamin M. Davis, Aaron N. Ingram, Duane Webb, Mariann Cary
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Patent number: 10420710Abstract: A vomit emission containment device is a device having an adjustable position container stand and container designed for placement of the container in close proximity to a nauseous person. The device has a stand with a vomit container holder having an accessory holder on the back side. The vomit container holder attaches to a stand that has a base, a vertical portion, and an arm that holds the container. Each section is joined by an adjustable angle elbow that together allows the container to be positioned horizontally and vertically.Type: GrantFiled: August 15, 2017Date of Patent: September 24, 2019Inventor: Jeremiah John Hunter
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Patent number: 10420711Abstract: Disclosed herein is a basic dental composition comprising an adhesive composition, wherein the dental composition is suitable for use in dentistry.Type: GrantFiled: July 5, 2018Date of Patent: September 24, 2019Assignee: DENTSPLY SIRONA Inc.Inventors: Huaibing Liu, Xiaoming Jin
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Patent number: 10420712Abstract: The subject matter of the invention is a three-dimensional molded body, in particular a milling blank, made of a polymerizable prosthetic material, which is suitable for milling machining by means of CNC and/or CAD/CAM, having a fracture toughness of greater than or equal to 1.9 Mpa·m1/2 and a fracture work of greater than or equal to 900 J/m2. The milling blank preferably comprises core-shell particles modified by an elastic phase and is optionally based on a content of urethane (meth)acrylate polymerized into the polymer. Moreover, a subject matter of the invention is the use of the milling blanks for the production of at least parts of dental prosthetic parts, such as a prosthesis, artificial teeth, bridges, or of orthodontic appliances and instruments in medical field.Type: GrantFiled: June 30, 2015Date of Patent: September 24, 2019Assignee: HERAEUS KULZER GMBHInventors: Klaus Ruppert, Alfred Hohmann, Stephan Dekert
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Patent number: 10420713Abstract: The invention relates to two different patches to be applied to a person's skin, namely a hydrogel patch and a dermal patch. The patches are preferably used in combination. A particularly preferred use of the patches is the post-treatment after tattooing. The patches' ingredients do not interact with the pigments used for tattooing and therefore the patches allow maintaining the color saturation of a tattoo.Type: GrantFiled: April 16, 2015Date of Patent: September 24, 2019Inventors: Jürgen Grasl, Dietmar Kowarik
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Patent number: 10420714Abstract: Disclosed herein are foaming cosmetic compositions comprising: at least one anionic thickening agent; at least two alkaline compounds; and at least one silicone. Methods for producing the foaming cosmetic compositions and for improving the stability of a foamed cosmetic composition are also disclosed.Type: GrantFiled: September 30, 2016Date of Patent: September 24, 2019Assignee: L'OREALInventors: Vanessa Comeron, Aziza Suleiman, Anand Mahadeshwar
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Patent number: 10420715Abstract: A method for protecting skin against damages caused by ultra-violet (uv) radiation from the sun, comprising administering to a subject in need of protection an effective amount of a composition containing lycopene from a natural source and one or more carotenoid selected from among phytoene and phytofluene or mixtures thereof.Type: GrantFiled: March 18, 2009Date of Patent: September 24, 2019Assignee: Lycored Ltd.Inventors: Morris Zelkha, Zohar Nir, Tanya Sedlov
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Patent number: 10420716Abstract: An oral care composition comprising (i) basic amino acid in free or salt form, (ii) calcium carbonate, (iii) a fluoride ion source, (iv) a flavoring agent comprising less than 50% menthol, and (v) an anionic surfactant, wherein the anionic surfactant is present in an amount from 1.00 weight % to 1.39 weight % is provided.Type: GrantFiled: October 15, 2018Date of Patent: September 24, 2019Assignee: Colgate-Palmolive CompanyInventors: Agnieszka Kocinska, Pierre Lambert, Sandra Pereira Ramos, Nadia Bueb, Joshua Schmid
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Patent number: 10420717Abstract: A hair treatment agent is provided herein. The hair treatment agent includes in a cosmetic carrier (a) at least one compound of the general formula (I). R1 denotes a hydrogen atom or a structural element of formula (II). x denotes an integer from 1 to 100. The radical R2 in each of the structural elements of formula (II) can be selected independently of the preceding structural element of formula (II). M1 denotes the grouping —OM2 or a structural element of formula (III). y denotes an integer from 1 to 100. M2 denotes a hydrogen atom, an equivalent of one or more cations or an ammonia ion (NH4)+.Type: GrantFiled: August 2, 2016Date of Patent: September 24, 2019Assignee: Henkel AG & Co. KGaAInventors: Georg Knuebel, Thomas Foerster, Erik Schulze zur Wiesche
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Patent number: 10420718Abstract: The present invention relates to effervescent compositions which are resistant to water vapor in the atmosphere and to methods of preparing such compositions. In particular, the invention relates to an effervescent composition comprising a co-crystal. The co-crystal comprises an acidic component and a basic component is separate. The co-crystal comprising the acidic component is resistant to water uptake avoiding initiating the effervescence prematurely. Upon dissolution of the co-crystal and the basic component effervescence occurs.Type: GrantFiled: July 2, 2015Date of Patent: September 24, 2019Assignee: University of BradfordInventors: Anant Paradkar, Sudhir Pagire
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Patent number: 10420720Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic dissolved in a solution comprising an extractive solvent, e.g., DMSO or NMP, in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered as a regional anesthesia to a subject to anesthetize a portion the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, or mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.Type: GrantFiled: May 3, 2017Date of Patent: September 24, 2019Assignee: The Board of Regents of the University of Texas SystemInventors: Christopher C. Capelli, Phillip C. Phan, Allen W. Burton
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Patent number: 10420721Abstract: This invention provides compositions comprising a protein, an absorption enhancer, a protease inhibitor, method for treating diabetes mellitus, comprising administering same, and methods for oral administration of a protein with an enzymatic activity, comprising orally administering same.Type: GrantFiled: June 6, 2018Date of Patent: September 24, 2019Assignee: Entera Bio Ltd.Inventors: Miriam Kidron, Ehud Arbit
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Patent number: 10420722Abstract: Dry powder vancomycin compositions and methods for administering and preparing such compositions are provided.Type: GrantFiled: December 10, 2015Date of Patent: September 24, 2019Assignee: SAVARA INC.Inventors: John Lord, Jaakko Taneli Jouhikainen, Herman E. Snyder, Pravin Soni, Mei-Chang Kuo
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Patent number: 10420723Abstract: A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. Further provided are methods for isolating a microvesicle that includes the steps of obtaining an amount of milk, and subjecting the milk to a series of sequential centrifugations configured to yield greater than about 300 mg of microvesicle protein per 100 ml of milk. Methods of modifying an immune response and treating a cancer in which a milk-derived microvesicle composition is administered are also provided.Type: GrantFiled: March 2, 2018Date of Patent: September 24, 2019Assignee: University of Louisville Research Foundation, Inc.Inventors: Ramesh C. Gupta, Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan
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Patent number: 10420724Abstract: Drug delivery using bio-affecting drugs, particularly with shape changing drug delivery devices. Embodiments are included for depots for delivery of a therapeutic agent that change from an elongated state ex vivo to a coil in vivo where the agent is released.Type: GrantFiled: November 23, 2016Date of Patent: September 24, 2019Assignee: Incept, LLCInventors: Peter Jarrett, Michael J. McGrath, Timothy S. Jarrett, Rami El-Hayek, Andrew C. Vanslette, Courtney A. Rosales, Charles D. Blizzard, Amarpreet S. Sawhney
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Patent number: 10420725Abstract: A solid dosage form comprises coated particles of bisphosphonate or a pharmaceutically acceptable analog or derivative thereof.Type: GrantFiled: October 9, 2015Date of Patent: September 24, 2019Assignee: Allergan Pharmaceuticals International LimitedInventors: Peter Persicaner, Craig Judy
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Patent number: 10420726Abstract: Orally administrable pharmaceutical compositions, methods of administration, and methods of making the same are provided. The pharmaceutical compositions provide abuse deterrent properties.Type: GrantFiled: March 18, 2014Date of Patent: September 24, 2019Assignee: INSPIRION DELIVERY SCIENCES, LLCInventors: Manish S. Shah, Ray J. Difalco, Stefan Aigner
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Patent number: 10420727Abstract: A pharmaceutical composition comprises at least one integrase inhibitor or its salt, solvate, complex, hydrate, isomer, ester, tautomer, anhydrate, enantiomer, polymorph or prodrug and at least one antiretroviral or anti-HIV agent or its salt, solvate, complex, hydrate, isomer, ester, tautomer, anhydrate, enantiomer, polymorph or prodrug.Type: GrantFiled: May 7, 2018Date of Patent: September 24, 2019Assignee: Cipla LimitedInventors: Geena Malhotra, Shrinivas Purandare
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Patent number: 10420728Abstract: Disclosed is a method for preparing a tablet. The method can improve the compressibility of the active ingredients and produce tablets of uniform quality, bringing about the advantage of increasing tablet hardness with an increase in compression pressure, easily controlling disintegration time, and decreasing tablet friability by using the active ingredient fimasartan, a pharmaceutically acceptable salt thereof or a hydrate or solvate thereof having a specific particle size distribution.Type: GrantFiled: January 11, 2016Date of Patent: September 24, 2019Assignee: Boryung Pharmaceutical Co., Ltd.Inventors: Jayhyuk Myung, Sung Chan Jeong, Yun Sam Kim
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Patent number: 10420729Abstract: The present invention is directed to an immediate release and extended release capsule or capsule fill which mitigates the abuse of abuse-susceptible active pharmaceutical ingredients by direct intravenous injection. The fill comprises a parenteral abuse resistant liquid formulation which when mixed with water and heated, results in a turbid, viscous or bubbling mixture that is not injectable with a standard insulin syringe. The abuse-susceptible active pharmaceutical ingredient is selected from the group consisting of opiates, opioids, tranquilizers, stimulants and narcotics.Type: GrantFiled: March 11, 2014Date of Patent: September 24, 2019Assignee: R.P. Scherer Technologies, LLCInventor: Simone Wengner
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Patent number: 10420730Abstract: A storage stable L-menthol composition including a tablet, caplet, capsule, or sachet dosage form has therein a core containing crystalline L-menthol and at least one pharmaceutical excipient. A proteinaceous coating of a continuous film of proteinaceous material is over the core. The film is effective to substantially prevent the crystalline L-menthol from volatilizing and leaving the core when stored at a temperature of 40 degrees C. and 75% relative humidity from between 1 day to 30 days. The dosage form contains an effective amount of the crystalline L-menthol for treating a gastrointestinal disorder.Type: GrantFiled: October 6, 2015Date of Patent: September 24, 2019Assignee: Zx Pharma, LLCInventors: Syed M. Shah, Fred Hassan
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Patent number: 10420731Abstract: A method of preparing lignin-based nanoparticles includes using a phase separation method, stabilized by citric acid (CA) crosslinking. The compositions include lignin-based nanoparticles (LG NPs) and a drug or pharmaceutical treating agent encapsulated in the LG NPs. A mean particle size diameter of the drug-loaded LG NPs can be less than 100 nm. The LG NPs improve oral bioavailability, and achieves rapid absorption of the encapsulated drug.Type: GrantFiled: January 18, 2019Date of Patent: September 24, 2019Assignee: King Saud UniversityInventors: Mohammed Saeed A. Alqahtani, Ali Saeed Althabit Alqahtani, Rabbani Syed S. Baji
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Patent number: 10420732Abstract: The present invention relates to the design and development of a drug delivery nanoplatform that consists of nanoporous, multi-layer biodegradable polymeric (BP) thin films for controlled release of its payload. The method is used notably to synthesize nanoporous BP coatings as drug delivery vehicles exhibiting uniform nanopores with tailored characteristics for control of drug delivery and release. It enables the multiplex delivery of drugs that can be eluted at desirable time intervals in line with each medical need. Atomic Force Microscopy and Spectroscopic Ellipsometry are applied for determining nanoporosity, thickness, drug loading, structural properties, and quality of the BP films ensuring the quality control of the final product. The complete degradation of the polymers minimizes the toxicity within the human body and such nanoplatform can be used in a wide range of drug eluting and other medical implants and biomedical devices.Type: GrantFiled: August 30, 2013Date of Patent: September 24, 2019Assignees: Aristotle University of Thessaloniki-Research CommitteeInventors: Stergios Logothetidis, Varvara Karagkiozaki
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Patent number: 10420733Abstract: Disclosed herein is a transdermal delivery system comprising methylphenidate or its salt as an active ingredient. Also provided are methods of delivering a therapeutically effective amount of methylphenidate to a subject for the treatment of a disease condition. The disease condition includes a neurological condition such as Attention Deficit Disorder (ADD) and/or Attention Deficit/Hyperactivity Disorder (ADHD). Kits including the transdermal delivery system and methods of making and using the transdermal delivery system are also provided.Type: GrantFiled: April 24, 2018Date of Patent: September 24, 2019Assignee: TAHO PHARMACEUTICALS LTD.Inventors: Shen-Yung Kao, Taijung Wu, Catherine Lee
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Patent number: 10420734Abstract: Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.Type: GrantFiled: March 28, 2015Date of Patent: September 24, 2019Assignee: Duke UniversityInventors: Suzanne E. Wardell, Erik R. Nelson, Donald P. McDonnell
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Patent number: 10420735Abstract: The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.Type: GrantFiled: October 17, 2018Date of Patent: September 24, 2019Assignee: NEVAKAR INC.Inventors: Tushar Hingorani, Prem Sagar Akasapu, Kumaresh Soppimath
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Patent number: 10420736Abstract: The present invention addresses the problem of providing an intraocular irrigating solution that allows the intraocular tissue to be sufficiently protected during ophthalmic surgery and further has high safety. The problem is solved by an intraocular irrigating solution containing at least one of active sulfur molecules of which examples include cysteine persulfide and glutathione persulfide.Type: GrantFiled: September 30, 2016Date of Patent: September 24, 2019Assignee: TOHOKU UNIVERSITYInventors: Toru Nakazawa, Takaaki Akaike, Hiroshi Kunikata
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Patent number: 10420737Abstract: A new compound composition that is free of a side effect to a liver and used for alleviating the toxicity of an acetaminophen (APAP) medicament to the liver. The compound composition comprises (a) a pharmaceutically effective amount of acetaminophen and (b) a frequently-used safe and pharmaceutically acceptable excipient that can be combined with one or more than two medicaments that can reduce the toxicity of a drug via liver enzyme CYP2E1 metabolism to the liver.Type: GrantFiled: November 13, 2013Date of Patent: September 24, 2019Assignee: NATIONAL DEFENSE EDUCATION AND RESEARCH FOUNDATIONInventors: Oliver Yao-Pu Hu, Tung-Yuan Shih
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Patent number: 10420738Abstract: An exemplary embodiment relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ?F508-CFTR, or another mutation of class II.Type: GrantFiled: December 15, 2015Date of Patent: September 24, 2019Assignee: INSTYTUT BIOCHEMII I BIOFIZYKI PANInventors: Norbert Odolczyk, Piotr Zielenkiewicz, Grzegorz Wieczorek, Aleksander Edelman, Danielle Tondelier, Janine Fritsch
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Patent number: 10420739Abstract: The present disclosure provides compositions and methods useful for the treatment of a body weight condition or a thyroid disorder. The compositions induces increased T3 levels while preventing thyroidal atrophy. Also provided are compositions and methods for the treatment of a disease or condition that is estrogen sensitive, estrogen receptor dependent or estrogen receptor mediated such as breast cancer.Type: GrantFiled: June 13, 2013Date of Patent: September 24, 2019Assignee: ThermoLife International, LLCInventors: Ronald Kramer, Alexander Nikolaidis
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Patent number: 10420740Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: GrantFiled: August 20, 2018Date of Patent: September 24, 2019Assignee: SAOL INTERNATIONAL LIMITEDInventors: Michael C. Schmitz, Corinne Dominguez, Thomas E. Keene, Deanna S. Lane, Lanchi T. Le, Jianwei Li, Ngoc T. Lu, Carmen E. Snaza
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Patent number: 10420741Abstract: The present invention includes cilastatin or a pharmaceutically acceptable salt thereof as an active component and a suppressant for renal impairment or inner ear disorders, induced via megalin by at least one megalin ligand which is selected from the group consisting of polymyxins, aminoglycoside antibiotics, glycopeptide antibiotics, cisplatin, and pharmaceutically acceptable salts thereof.Type: GrantFiled: July 21, 2016Date of Patent: September 24, 2019Assignees: EA Pharma Co., Ltd., Niigata UniversityInventors: Akihiko Saito, Nobumasa Aoki, Yoshihisa Hori, Shoji Kuwahara, Michihiro Hosojima, Hiroshi Iwata, Saori Matsuda
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Patent number: 10420742Abstract: Disclosed herein are compositions and methods for treating or preventing certain cancers in a subject. In certain embodiments such compositions and methods generally relate to the use of G-coupled protein receptor 40 (GPR40) agonists to inhibit the growth or induce apoptosis of certain cancer cells. The compositions and related methods disclosed herein may be used to treat subjects affected by cancers, such as melanoma, medullary thyroid carcinoma, malignant peripheral nerve sheath tumors and neuroblastoma, and to reduce the incidence of metastases in such affected subjects.Type: GrantFiled: September 14, 2017Date of Patent: September 24, 2019Assignee: The Children's Medical Center CorporationInventors: Mark Puder, Deepika Nehra, Brian Kalish