Abstract: A method of writing to a magnetic random access memory cell includes applying an alternating current signal to the magnetic random access memory cell having a first magnetic orientation, and applying a direct current pulse to the magnetic random access memory cell to change the magnetic orientation of the magnetic random access memory cell from the first magnetic orientation to a second magnetic orientation. The first magnetic orientation and the second magnetic orientation are different.

Abstract: Methods, systems, and devices for activity-based data protection in a memory device are described. In one example, a memory device may include a set memory sections each having memory cells configured to be selectively coupled with access lines of the respective memory section. A method of operating the memory device may include determining a quantity of access operations performed on a set of sections of a memory device, selecting at least one of the sections for a voltage adjustment operation based on the determined quantity of access operations, and performing the voltage adjustment operation on the selected section. The voltage adjustment operation may include applying an equal voltage to opposite terminals of the memory cells, which may allow built-up charge, such as leakage charge accumulating from access operations of the selected memory section, to dissipate from the memory cells of the selected section.

Abstract: Methods, systems, and devices for section-based data protection in a memory device are described. In one example, a memory device may include a set memory sections each having memory cells configured to be selectively coupled with access lines of the respective memory section. A method of operating the memory device may include selecting at least one of the sections for a voltage adjustment operation based on a determined value of a timer, and performing the voltage adjustment operation on the selected section by activating each of a plurality of word lines of the selected section. The voltage adjustment operation may include applying an equal voltage to opposite terminals of the memory cells, which may allow built-up charge, such as leakage charge accumulating from access operations of the selected memory section, to dissipate from the memory cells of the selected section.

Abstract: An apparatus may include an address counter to provide first address information and second address information. The first address information may include a first number of bits and the second address information may include a second number of bits that is smaller than the first number of bits. The address counter may perform a first updating operation. The first updating operation being such that the first address information is updated from a first initial value to a first final value. The address counter may also perform a second updating operation, the second updating operation being such that the second address information is updated from a second initial value to a second final value. In addition, the address counter may also perform the second updating operation at least twice per the first updating operation being performed once.

Abstract: Apparatuses and methods for a command decoder delay are disclosed. An example apparatus includes a command decoder which may receive memory access command. The command decoder may provide an output command based on the memory access command to a command path at a first time. The command decoder may also provide the output command to a data path at a second time, wherein the second time is delayed relative to the first time.

Abstract: A memory device includes a target clock generation circuit suitable for generating a target clock by dividing a frequency of an internal clock at a set ratio, a delay circuit suitable for generating first to Nth delay clocks having first to Nth pulse widths that gradually increase, in synchronization with the target clock, a flag detection circuit suitable for filtering the first to Nth delay clocks based on the target clock to generate first to Nth flag signals and decoding the first to Nth flag signals to generate first to (N?1)th current control signals, and a buffer circuit suitable for adjusting an amount of current based on the first to (N?1)th current control signals, and buffering an externally inputted signal using the adjusted amount of current.

Abstract: Disclosed herein is an apparatus that includes a memory cell array, a row hammer refresh circuit configured to generate a row hammer refresh address based on an access history of the memory cell array, a redundancy circuit configured to store a plurality of defective addresses of the memory cell array, and a row pre-decoder configured to skip a refresh operation on the row hammer refresh address when the row hammer refresh address matches any one of the plurality of defective addresses.

Abstract: The present disclosure includes apparatuses and methods for performing operations by a memory device in a self-refresh state. An example includes an array of memory cells and a controller coupled to the array of memory cells. The controller is configured to direct performance of compute operations on data stored in the array when the array is in a self-refresh state.

Abstract: Examples of the present disclosure relate to a device, method, and medium storing instructions for execution by a processor for refreshing memory blocks of solid state memory through a temperature compensated refresh rate. Techniques discussed herein include a solid state memory to store data and a temperature sensor to identify a temperature of the solid state memory. The memory device with solid state memory also includes a memory controller that periodically refreshes memory blocks of the solid state memory at an adjustable refresh rate, wherein memory controller is to adjust the adjustable refresh rate based on the temperature of the solid state memory.

Abstract: An electronic device (e.g., a superconducting memory cell) includes a substrate and a layer of superconducting material disposed over the substrate. The layer of superconducting material is patterned to form a plurality of distinct instances of the layer of superconducting material including: a first wire; and a loop that is (i) distinct and separate from the first wire and (ii) capacitively coupled to the first wire while the loop and the first wire are in a superconducting state. The loop is configured to form a persistent current via the capacitive coupling in response to a write current applied to the first wire while the loop and the first wire are in the superconducting state. The persistent current represents a logic state of the electronic device.

Abstract: A semiconductor memory apparatus may include a memory bank, a global buffer array, and an input and output circuit. The memory bank includes a local data circuit, and the global buffer array includes a global data circuit. The local data circuit is operably coupled to the global data circuit. The global buffer array may be operably coupled to the input and output circuit. The memory bank is disposed in a core region, and the global buffer array and the input and output circuit may be disposed in a peripheral region separated from the core region.

Abstract: A semiconductor memory apparatus includes a memory cell coupled between a bit line and a word line. A sensing line is disposed adjacent to the word line to form a capacitor together with the word line. A sense amplifier coupled to the sensing line generates an output signal by detecting a voltage level of the sensing line.

Abstract: Crossbar arrays with reduced disturbance and methods for programming the same are disclosed. In some implementations, an apparatus comprises: a plurality of rows; a plurality of first columns; a plurality of second columns; a plurality of devices. Each of the plurality of devices is connected among one of the plurality of rows, one of the plurality of first columns, and one of the plurality of second columns. The device further comprises a shared end on the plurality of first columns or the plurality of the second columns connecting to the plurality of the devices in the same row or column; the shared end is grounding or holds a stable voltage potential. In some implementations, one of the devices is: a RRAM, a floating date, a phase change device, an SRAM, a memristor, or a device with tunable resistance. In some implementations the stable voltage potential is a constant DC voltage.

Abstract: Aspects of the present disclosure configure a media controller of a memory component to skip execution of a read-write cycle for specific data if the media controller has not observed at least one prior data modification request from a memory sub-system controller that causes modification of the specific data. For example, a media controller of a first memory component can be configured to include a data modification tracker to monitor a memory channel for data modification requests to a second memory component and to track data modification requests that have been observed by the media controller on the memory channel, where the memory channel may be one shared by the first and second memory components.

Abstract: An array includes a shared pulse generator and a plurality of cells. A selected cell the plurality of cells includes a phase-change material (PCM) and a heating element, the heating element being transverse to the PCM. The array further includes a row selector configured to connect the shared pulse generator to the selected cell, and a column selector configured to connect the selected cell to a ground. The shared pulse generator provides an electrical pulse to cause the heating element in the selected cell to generate a heat pulse. In one approach, the selected cell also includes a non-linear device such as a diode, and the shared pulse generator provides the electrical pulse to a PCM RF switch of the selected cell through the non-linear device to change a state of the PCM RF switch.

Abstract: A memory array includes (a) multiple memory cells arranged into a plurality of bytes, (b) a separate word line connected to each byte, and (b) multiple shared source lines, each connected to at least two bytes, such that each byte in the array is addressable by a separate word line and by the shared source line. Due to this memory array architecture, a program operation on a first byte applies a shared source line voltage on a non-selected second byte (with an inhibit voltage applied to bit lines connected to the second byte), which creates a disturb condition that corresponds with a diagonal (or row) program disturb condition in a conventional memory array. The use of the shared source lines may reduce the required number of source line drivers, which reduces the overhead area of the memory array, and at same time, allow backward compatibility of traditional byte-alterable EEPROM.

Abstract: Numerous embodiments are disclosed for a high voltage generation algorithm and system for generating high voltages necessary for a particular programming operation in analog neural memory used in a deep learning artificial neural network. Different calibration algorithms and systems are also disclosed. Optionally, the duration of a programming voltage can change as the number of cells to be programmed changes.

Abstract: Numerous embodiments are disclosed for a high voltage generation algorithm and system for generating high voltages necessary for a particular programming operation in analog neural memory used in a deep learning artificial neural network. Different calibration algorithms and systems are also disclosed. The system can modify a high voltage signal applied to an array of cells during a programming operation as the number of cells being programmed changes.

Abstract: Embodiments of three-dimensional memory device architectures and methods of operating the devices therefore are disclosed. A method of erasing memory cells of a memory device includes applying a first voltage greater than 10 V to a first semiconductor layer of one or more first vertical structures. The method further includes applying a second voltage greater than 10 V to a second semiconductor layer of one or more second vertical structures stacked over the one or more first vertical structures. The method also includes grounding each of a plurality of word lines. The plurality of word lines are arranged in an alternating stack with insulating layers over a substrate, and the one or more first vertical structures and the one or more second vertical structures extend through the alternating stack.

Abstract: A storage device includes a nonvolatile memory device including a memory block and a memory controller. The memory block includes a first memory region connected with a first word line and a second memory region connected with a second word line. The memory controller sets a read block voltage based on a first read voltage of the first memory region. The memory controller determines a second read voltage of the second memory region based on variation information and the read block voltage.

Abstract: A sense structure includes: a sense amplifier core configured to compare a measurement current with a reference current; a cascode transistor coupled to the sense amplifier core and configured to be coupled to a load; a switch coupled between a bias voltage node and a control terminal of the cascode transistor; a local capacitor having a first terminal coupled to the control terminal of the cascode transistor; a first transistor coupled between a second terminal of the local capacitor and a reference terminal; and a control circuit coupled to a control terminal of the first transistor, the control circuit configured to disconnect the local capacitor from the reference terminal to produce a voltage overshoot in the control terminal of the cascode transistor, and after disconnecting the local capacitor from the reference terminal, limit or reduce the voltage overshoot by adjusting a voltage of the control terminal of the first transistor.

Abstract: A circuit includes an eFuse and a first program device coupled in series between a bit line and a program node, and a second program device configured in parallel with the first program device. The first program device and the second program device are separately controllable.

Abstract: A shift register unit, a driving method and a gate driving circuit are provided. The shift register unit includes a pull-up node control circuit, a pull-down node control circuit, a capacitor circuit, an output circuit and a noise reduction adjustment circuit. The noise reduction adjustment circuit is connected to a pull-down node and a first level input end, and configured to reduce an increasing rate of a potential at the pull-down node within a noise reduction time period of a maintenance phase, and reduce a decreasing rate of the potential at the pull-down node within a non-noise-reduction time period of the maintenance phase.

Abstract: Memory devices and methods are described that include a stack of memory dies and a logic die. Method and devices described include those that provide for repartitioning the stack of memory dies and storing the new partitions in a memory map. Repartitioning in selected configurations allows portions of memory to be removed from use without affecting the rest of the memory device. Additional devices, systems, and methods are disclosed.

Abstract: Systems, methods, and computer program products directed to testing a System-in-a-Package (SIP) using an Automatic Test Equipment (ATE) machine. A functional representation of one or more tests to be performed in the SIP is loaded in a memory located on a load board, the load board located on the ATE machine. A test controller located on at least one of the SIP and the load board is caused to retrieve and store the one or more tests to be performed in the SIP. The test controller is instructed to conduct the one or more tests in the SIP.

Abstract: A storage device including a nonvolatile memory device, a dynamic random access memory (DRAM) device, and a storage controller, an operation method of the storage device including performing an access operation on the DRAM device, collecting accumulated error information about the DRAM device based on the access operation, detecting a fail row of the DRAM device based on the accumulated error information, and performing a runtime repair operation on the detected fail row.

Abstract: A method for calculating binding free energy, the method including: adding predetermined restraint potential between a first substance and a second substance to determine potential energy of a binding structure between the first substance and the second substance; selecting potential energy used for a calculation of binding free energy from potential energy data present within a restraining space corresponding to a state where the maximum level of the predetermined restraint potential is added among an entire potential energy data determined in the adding; and calculating binding free energy between the first substance and the second substance using the potential energy selected, wherein the method is a method for calculating binding free energy between the first substance and the second substance using a computer.

Abstract: A method for designing and selecting a protein having a stabilized structure compared to a corresponding wild type protein, and proteins having at least six amino acid substitutions with respect to a corresponding wild type protein, designed for improved thermal stability, improved specific activity and/or improved expression levels, are provided herein.

Abstract: A computing server may use one or more recommender systems to predict phenotypes of individuals based on survey responses, other phenotypes, environmental factors, and genetic data of the individuals. The computing server may retrieve survey responses of a set of individuals regarding a set of phenotypes of the individuals. The computing server may construct a matrix that includes the values of the phenotypes. The computing server may predict an undetermined phenotype of a target individual using collaborative filtering, which provides the prediction based on other phenotypes of the target individuals and based on at least another individual's phenotypes. The computing server may also predict a target phenotype based on the phenotype of other individuals who are similar to the target individual. The computing server may determine another individual is similar to the target individual based on the length of identity-by-descent (IBD) segments between the two individuals.

Abstract: Disclosed is a method of quantitatively analyzing a target protein population in a sample to be analyzed, the method including (a) treating a sample to be analyzed with an aptamer library specific to a target protein population present in the sample so as to form complexes between target proteins and aptamers binding specifically thereto, thereby forming a target protein-aptamer complex population, (b) isolating the complex population from unbound aptamers, and (c) analyzing the sequence of each aptamer of the complex population through a next-generation sequencing process so as to quantify each aptamer of the complex population, thereby quantifying each target protein in the complex population. The method of the present invention can be very useful in collectively quantifying proteins in an analytical sample.

Abstract: The present invention relates to optimization logic for preparing an optimal combination of oligonucleotides hybridized with a plurality of target nucleic acid sequences, in a completely different approach from conventional methods, i.e., empirical and manual methods. In addition, the optimization logic of the present invention may be used to (i) preparing an oligonucleotide combination used to detect a plurality of target nucleic acid sequences with a target coverage of interest, (ii) selecting target nucleic acid sequences to be detected by a multiplex target detection with a highest target coverage by using a limited number of oligonucleotides, and (iii) determining a conserved region in a plurality of target nucleic acid sequences.

Abstract: Disclosed herein include systems, methods, compositions, and kits for sample identification and protein expression profiling. A sample indexing composition, or a composition for protein expression profiling, can comprise, for example, a protein binding aptamer associated with an oligonucleotide, such as a sample indexing oligonucleotide. Different oligonucleotides can have different sequences. Sample origin of cells, or protein expression profiles of cells, can be determined based on the sequences of the oligonucleotides by, for example, barcoding the oligonucleotides.

Abstract: Provided herein are methods, processes, systems, machines and apparatuses for non-invasive assessment of chromosome alterations.

Abstract: Methods and systems for searching genomes for potential nucleotide-guided nuclease off-target sites are provided. Also provided are methods of searching genomes for potential off-target deadCas9 binding sites. In some embodiments, the methods include ranking the potential off-target sites based on the number and location of mismatches, insertions, and/or deletions in the DNA, RNA, or DNA/RNA guide sequence relative to the genomic DNA sequence at a putative target site in the genome, allowing the selection of better target sites and/or experimental confirmation of off-target sites.

Abstract: Systems and methods for analyzing genomic information can include obtaining a sequence read including genetic information; identifying, within a graph representing a reference genome, a plurality of candidate mapping positions that relate to the genetic information, the graph comprising nodes representing genetic sequences and edges connecting pairs of nodes; determining, by means of a computer system, whether an alignment with the graph surrounding each of the plurality of candidate mapping positions is advanced or basic; and performing for each candidate mapping position, by means of the computer system, a local alignment based on whether the local alignment is advanced or basic. The advanced local alignment can include a first-local-alignment algorithm, and the basic local alignment includes a second-local-alignment algorithm. Based on the local alignments, the mapped position of the sequence read can be identified within the genome.

Abstract: Techniques and systems for determining a correct alignment of nucleic acid sequences are described. Determining the correct alignment may include generating multiple reference sequences that include one or more variants and aligning the nucleic acid sequences to the multiple reference sequences. The correct alignment may include performing an alignment of the nucleic acid sequences using the multiple reference sequences and determining the correct alignment for the nucleic acid sequences based at least in part on a result of the alignment using the multiple reference sequences.

Abstract: Systems, methods and computer-readable media are provided to predict properties of a material that is related to a bioreachable molecule by generating a chemical model of the material based on physicochemical properties and predicting properties of the material based at least in part upon the chemical model and correlative modeling. The material may comprise in its chemical structure one or more instances of the bioreachable molecule. The material may comprise in its chemical structure the bioreachable molecule or at least one semi-synthetic molecule derived from the bioreachable molecule, or a combination thereof.

Abstract: Techniques for generating therapy biomarker scores and visualizing same. The techniques include determining, using a patient's sequence data and distributions of biomarker values across one or more reference populations, a first set of normalized scores for a first set of biomarkers associated with a first therapy, and a second set of normalized scores for a second set of biomarkers associated with a second therapy, generating a graphical user interface (GUI) including a first portion associated with the first therapy and having at least one visual characteristic determined based on a normalized score of the respective biomarker in the first set of normalized scores; and a second portion associated with a second therapy and having at least one visual characteristic determined based on a normalized score of the respective biomarker in the second set of normalized scores; and displaying the generated GUI.

Abstract: Method and system for storing and accessing genomic data. Genomic sequencing data are partitioned into access units of different types based on the predictability of the contained data. Access units are classified in different types and the structuring enables selective access and selective processing of genomic data.

Abstract: Embodiments of the invention are generally directed to compressing genetic sequencing data. In many embodiments, the genetic sequencing data is reordered and encoded based on sequence homology between individual sequencing reads within the genetic sequencing data. Several embodiments are directed to systems to compress genetic sequencing data, and some embodiments are directed to non-transitory, machine-readable media that direct a processor to compress genetic sequencing data. In further embodiments, the genetic sequencing data represents paired-end sequencing data, and several embodiments transmit the data to a remote device.

Abstract: The invention provides tools and methods for improving the quality and efficiency of clinical trials, including designing clinical trials that do not require a placebo group. In one aspect, the invention provides a method of identifying placebo responders. In another aspect, the invention provides a method for calculating and/or estimating a placebo risk score for one or more individual subjects. In yet another aspect, the invention provides a method for adjusting results of a clinical trial by removing the placebo responders and/or the portion of their response attributable to placebo effect. In an additional aspect, the invention provides a method of measuring the response of an individual to treatment that is not attributable to placebo effect.

Abstract: Systems and methods are disclosed for monitoring, recording, verifying, auditing, and executing healthcare communications, decisions, and transactions using centralized storage and blockchain technology. The healthcare communications relate to communications between a patient, doctor, specialist, healthcare provider, a private or government entity that processes and reimburses healthcare providers, insurance provider, and a healthcare facility. Systems and methods are disclosed for processing, monitoring, recording, verifying, auditing, and executing healthcare communications, decisions, and transactions using centralized storage and blockchain technology. The healthcare communications relate to communications between a patient, doctor, specialist, healthcare provider, a private or government entity that processes and reimburses healthcare providers, insurance provider, and a healthcare facility.

Abstract: Systems and methods are disclosed for monitoring models for bias. In one implementation, a system for automatically assessing a deployed model for selection of a cohort may include a processing device programmed to: apply the deployed model to data representing a first plurality of individuals, the data including at least one characteristic of the first plurality of individuals; based on the application, select a subset of the first plurality of individuals as a cohort; receive data representing a second plurality of individuals labeled as within the cohort, the data including the at least one characteristic of the second plurality of individuals; compare the selected subset and the second plurality of individuals along the at least one characteristic; and determine whether the comparison results in a difference between the selected subset and the second plurality of individuals greater than a threshold.

Abstract: Systems and methods are disclosed for monitoring models for bias. In one implementation, a system for automatically assessing a deployed model for selection of a cohort may include a processing device programmed to: apply the deployed model to data representing a first plurality of individuals, the data including at least one characteristic of the first plurality of individuals; based on the application, select a subset of the first plurality of individuals as a cohort; receive data representing a second plurality of individuals labeled as within the cohort, the data including the at least one characteristic of the second plurality of individuals; compare the selected subset and the second plurality of individuals along the at least one characteristic; and determine whether the comparison results in a difference between the selected subset and the second plurality of individuals greater than a threshold.

Abstract: A medical information management apparatus including an integrated data index file generating unit that generates an integrated data index file in which an index indicating a storage location of surgical data which is various types of data acquired during surgery is integrated with an index indicating a storage location of patient information of a patient which is a subject of the surgery for each surgery is provided.

Abstract: The drug inspection assisting apparatus includes: a drug collating unit configured to collate a reference image of each drug listed in the prescription and a collation-target image based on a captured image of drugs packaged in the packaging bag and determine whether or not the drug shown by the collation-target image and the drug shown by the reference image are the same drug; a listing-table creating unit configured to create, for each kind of the drugs to be packaged in the packaging bag, a listing table including the reference image of drug to be dispensed according to the prescription and all images which are determined to show the same drug as the drug shown by the reference image, among collation-target images; and a display control unit configured to cause a display device to display the listing table for a single kind of drug on a display screen.

Abstract: An artificial intelligence insulin pump that processes glucose data, wellness data, external data, and port information to determine the appropriate amount and timing of insulin to deliver to a person. External data includes data from sources remote from the insulin pump and the user such as social media data, GPS location data, historical data including energy and food intake at locations visited prior, data from third party sources. Such external data may include that the use is registered for a marathon and in at the marathon venue and the user's exertion level indicates that the user is running has begun to run the marathon. The AI engine would than adjust the insulin appropriately.

Abstract: A system and method for functioning as a companion robot (11) to provide services to a user, collect data and information about the local environment to the robot and the user, and communicate with the user and to a remote processing means. A plurality of sensors are adapted to: (i) probe an environment in which the companion robot and user is disposed and generate data in respect of the environment; and sense information about the user and generate data containing the information. A communication means communicates: (i) sensorially perceptive information to the user; and (ii) data containing information to a remote processing means. A processing means: (i) receives data from the sensors; (ii) processes the data to extract information therefrom and perform prescribed functions with the information; and (iii) provides output information and data to the communication means.

Abstract: An image viewer and method for using the same in a medical image management system are described.

Abstract: A system and method are provided for selecting an acquisition parameter for an imaging system. The acquisition parameter at least in part defines an imaging configuration of the imaging system during an imaging procedure with a patient. A depth-related map is accessed which is generated on the basis of sensor data from a camera system, wherein the camera system has a field of view which includes at least part of a field of view of the imaging system, wherein the sensor data is obtained before the imaging procedure with the patient and indicative of a distance that parts of the patient's exterior have towards the camera system. A machine learning algorithm is applied to the depth-related map to identify the acquisition parameter, which may be provided to the imaging system.