Abstract: The present invention relates to diagnostic and prognostic methods and kits for assessing chronic inflammation and associated immune-suppression. More particularly, the invention relates to the use of SNX9 (sorting nexin 9 protein) as a biomarker for chronic inflammation and associated immune-suppression, specifically, in subjects suffering from chronic inflammatory conditions. The invention further provides a prognostic tool for detecting regression or recurrence of the diseases and a powerful tool for assessing efficacy of a treatment. The present invention further provides SNX9 as an immunomodulator and therefore relates to methods for treating immune-related disorders by modulating SNX9 expression.

Abstract: Biomarkers of kidney function and methods for using said biomarkers for assessing kidney function, monitoring kidney function, diagnosing acute kidney injury, and diagnosing chronic kidney disease are provided. Also provided are suites of small molecule entities as biomarkers for chronic kidney disease.

Abstract: The present invention provides diagnostic and therapeutic methods and compositions for treating a patient suffering from an interleukin-1 receptor-associated kinase 4 (IRAK4)-mediated disorder or condition, such as an immune disorder (e.g., systemic lupus erythematosus (SLE)) or an inflammatory disorder (e.g., asthma). The invention provides diagnostic methods of monitoring the response of a patient having an IRAK4-mediated disorder or condition to treatment including an IRAK4 pathway inhibitor, methods of identifying a patient having an IRAK4-mediated disorder or condition who may benefit from treatment including an IRAK4 pathway inhibitor, and methods of selecting a therapy for a patient having an IRAK4-mediated disorder or condition based on the expression level of one or more IRAK4 biomarkers (e.g., one or more genes set forth in Table 1). Related therapeutic methods and compositions (e.g., diagnostic kits) are also provided.

Abstract: The present subject matter provides, inter alia compositions, systems, kits and methods for diagnosing and treating small vessel diseases (SDVDs).

Abstract: A blood coagulation analyzing method according to one or more aspects may include: calculating a coagulation time based on data representing a coagulation curve of a change in an optical detection value of a blood specimen added with a reagent for starting a coagulation reaction; calculating an index value related to derivatives calculated concerning the coagulation curve represented by the data used in the calculating the coagulation time; and determining whether an early reaction error has occurred based on a comparison result obtained by comparing the index value to a predetermined threshold.

Abstract: Disclosed is a reagent for determination of activated partial thromboplastin time, comprising: a phosphatidylcholine (PC); a phosphatidylserine (PS); and a phosphatidylethanolamine (PE), wherein a concentration ratio of the PS relative to the PC is not less than 0.16 and not more than 0.25, and a concentration of the PS is not less than 7 ?g/mL and not more than 13 ?g/mL.

Abstract: Provided are a biomarker for diagnosing of the level of senescence, a composition and kit for diagnosing of the level of senescence to detect the biomarker, and a method of diagnosing the same. According to the composition and kit for the diagnosis of the level of senescence and the method of diagnosing senescence, the level of senescence of a subject is easily diagnosed, the health conditions of the subject are monitored, and a senescence-associated disease is prevented or diagnosed.

Abstract: Disclosed is a method for obtaining information on subject's diabetes, comprising measuring lipoprotein's ability to uptake sterol in a biological sample of a subject, wherein a measured value of ability to uptake sterol per unit volume of the biological sample is an indicator of diabetes onset risk.

Abstract: Advantage is taken of macrolide antibiotics' complexation with free cholesterol to yield fluorescent complexes to determine the levels of free cholesterol, total cholesterol, or lecithin: cholesterol acyl transferase (LCAT) in serum or plasma or fractions thereof or to determine the level of cholesterol esterase in a sample.

Abstract: Disclosed is a specimen measurement apparatus that includes a measurement unit configured to measure a specimen; a detector configured to detect at least one of a container that can store the specimen or a cap of the container; and a movement mechanism configured to move at least one of the container or the detector. In the specimen measurement apparatus, the detector detects at least one of the container and the cap in a state where the movement mechanism is moving the container relative to the detector.

Abstract: An analyzer for testing a biological sample is proposed, wherein the analyzer comprises a pressurized gas supply having an intermediate gas storage that is fluidically arranged between an intermediate valve and an actuation valve. A method for testing a biological sample is proposed, wherein the power supply of an intermediate valve is cut off when the valve starts to change its position and/or wherein the pressure of an intermediate gas storage located downstream of an intermediate valve is controlled. Further, a method for inspecting an analyzer, in particular its pressurized gas supply, is proposed, wherein the pressure drop in a main gas storage is measured and compared to a reference pressure drop in order to inspect the analyzer.

Abstract: This specimen analyzer includes: an analysis unit which analyzes a specimen collected from a subject; a manual input unit which receives an input of information by manual operation; an information read unit which receives an input of information by reading an information record section provided in a consumable; and a controller which does not permit an input of information on the consumable with the manual input unit, and permits an input of the information on the consumable with the information read unit.

Abstract: Disclosed is a calibration curve creation method performed by an analyzer, the calibration curve creation method including: preparing a plurality of calibrators at different dilution rates by dispensing a calibrator in a container into one or more different containers; obtaining a plurality of measurement values by measuring each of the prepared plurality of calibrators; creating a calibration curve by use of the plurality of measurement values; selecting a first measurement value to be re-measured, among the plurality of measurement values used for the calibration curve; preparing another calibrator at a dilution rate corresponding to a calibrator from which the selected first measurement value is obtained; obtaining a second measurement value by measuring the prepared another calibrator; and creating a new calibration curve by replacing the first measurement value, among the plurality of measurement values, with the second measurement value.

Abstract: A method according to one or more aspects may be for displaying measurement results of measurement items by a sample analyzer. The method may include displaying each of the measurement items selectably on a display unit, and displaying a notification concerning any of the measurement results in association with the corresponding measurement item on the display unit; and in response to selection of at least one of the measurement items, displaying the measurement result of the selected at least one of the measurement items on the display unit.

Abstract: A sample receptacle can be used for ordering assays to be performed by an automatic sample processing instrument. The sample receptacle can include a body defining a chamber for containing a sample and a label. The label can include discrete areas configured to be altered from a first assay order state to a second assay order state. Each discrete area has a known association with a different assay. The label can also include assay-identifying indicia indicating the respective assay associated with a respective discrete area. A method of processing a sample in a receptacle having one or more assay order states can include automatically determining assay order states of the discrete areas and performing an assay on the sample, using the automatic sample processing instruments, based on the determined assay order states of the discrete areas.

Abstract: Disclosed is an analyzer including an analysis unit configured to analyze a specimen; a first storage part capable of storing a container capable of containing the specimen, the first storage part including an outlet that allows the container to be discharged therethrough; a second storage part capable of storing the container having been discharged through the outlet of the first storage part; a transporter configured to send out, from the second storage part, the container stored in the second storage part; and a discharge controller capable of controlling discharge of the container through the outlet of the first storage part.

Abstract: The present invention provides a sample extraction device, comprising an extraction table and an operating and moving module. The operating and moving module comprises a first horizontal movement module, a first vertical movement module, and a suction module. The suction module is provided on a supporting frame of the first horizontal movement module, and comprises a second vertical movement module and an injector, the second vertical movement module is configured to move vertically with respect to the extraction table, the injector has an airtight cylinder and a piston rod, and the airtight cylinder is connected to the gas delivery tube; wherein the second vertical movement module moves vertically to push or pull the airtight cylinder or the piston rod, in order for the injector to generate positive or negative pressure. The sample extraction device of the present invention can reduce the space required for operation substantially.

Abstract: A method includes irradiating a target droplet in an extreme ultraviolet light source of an extreme ultraviolet lithography tool with light from a droplet illumination module. Light reflected and/or scattered by the target droplet is detected. Particle image velocimetry is performed to monitor one or more flow parameters inside the extreme ultraviolet light source.

Abstract: Some embodiments include a handheld detector, comprising: detector circuitry configured to convert incident radiation into electrical signals; a processor coupled to the detector circuits; and an accelerometer coupled to the processor; wherein the processor is configured to activate from a low power state in response to a first acceleration event detected by the accelerometer.

Abstract: The present disclosure discloses a vertical superconducting magnetic mass-spring oscillator with an adjustable natural frequency, comprising: a proof mass, a negative-stiffness superconducting coil and a positive-stiffness superconducting coil; the negative-stiffness superconducting coil is mounted at an opening of a semi-closed space of the proof mass, so that a part of magnetic lines of the negative-stiffness superconducting coil are in a compressed state in a closed space of the proof mass, and the other part of the magnetic lines of the negative-stiffness superconducting coil are in an expanded state outside the closed space of the proof mass; a vertical magnetic repulsive force applied to the proof mass by the negative-stiffness superconducting coil varies with a displacement of the proof mass from an equilibrium position, with the variation magnitude proportional to the displacement and the variation direction the same as the displacement direction; and the positive-stiffness superconducting coil is mou

Abstract: A method for generating a sensor output from the outputs of first and second sensors is provided. The method comprising receiving the outputs from the first and second sensors; estimating an offset between the outputs of the first and second sensors over a first range of outputs; adjusting the output of the second sensor based on the estimated offset; and generating a sensor output, based on the output of the first sensor, the adjusted output of the second sensor and a blending function that blends the output of the first sensor and the adjusted output of the second sensor.

Abstract: Method for detecting sensor errors, wherein measurements are taken, discharge time data with a first discharge time constant is read out from a data storage unit of the sensor and corresponding measurement signals as well as the discharge time data are transmitted to a computing unit, where a signal processing, a signal evaluation and a data evaluation occur in the computing unit and filtered signals are formed by filtering the measurement signals, where parameter values of a discharge function are determined via a logarithmic function of the filtered signals, a second discharge time constant is determined from the discharge function and where the first discharge time constant and the second discharge time constant are compared to detect errors, faults or damage of the sensor such that the influences of sensor errors on the measurements can be reduced.

Abstract: The present disclosure provides a scanning probe, a method and an apparatus for manufacturing the scanning probe. The scanning probe includes a base and a micro-tip disposed on an end of the base, wherein at least a section of the micro-tip comprises a lateral surface with a concavely curved generatrix. In the method, an end of a probe precursor is immersed in a corrosive solution by having a length direction of the probe precursor inclined with a liquid surface of the corrosive solution. The probe precursor is corroded by the corrosive solution while a corrosion current of the corroding is monitored. The probe precursor is moved away from the corrosive solution after a magnitude of the corrosion current has a plunge. The apparatus includes a container containing the corrosive solution, and a driving device configured to move the probe precursor in the container through a fastener.

Abstract: An electronic component handler that transports an electronic component to a test unit testing electric characteristics of the electronic component and having a socket member provided with a recess in which the electronic component is placed, includes a reference base having a reference surface in which the socket member is disposed, a measuring unit that measures positions in a normal direction of the reference surface with respect to a plurality of points of the socket member, a display unit, and a control unit that displays position information based on the positions of the plurality of points on the display unit.

Abstract: A device probe includes a primary probe arm and a subsequent probe arm with a slip plane spacing between the primary probe arm and subsequent probe arm. Each probe arm is integrally part of a probe base that is attachable to a probe card. During probe use on a semiconductive device or a semiconductor device package substrate, overtravel of the probe tip allows the primary and subsequent probe arms to deflect, while sufficient resistance to deflection creates a useful contact with an electrical structure such as an electrical bump or a bond pad.

Abstract: A probe card device includes a probe head including a plurality of pins, wherein each of the pins includes a body, a first metal layer formed on the body, and a second metal layer covering the first metal layer; a multi-layered flexible board electrically connected to the pins; a support plate, the multi-layered flexible board disposed on a first surface of the support plate; and a circuit board electrically connected to the multi-layered flexible board.

Abstract: The present invention provides a probe card holder including a plate-shaped frame formed with an opening approximately the same size as the probe card, a plurality of card bottom surface holding portions that are provided around a peripheral edge of the opening in the frame and that hold a bottom surface of the probe card while biasing the bottom surface, and a plurality of card top surface supporting portions that support the top surface of the probe card. Each card bottom surface holding portion includes an L-shaped member with a base portion and a bottom surface supporting portion, a knob that is linked to a tip end portion of the base portion and a biasing member that is disposed between the knob and the top surface of the frame and that biases the bottom surface supporting member upward toward the bottom surface of the frame.

Abstract: A signal processing device is described, with a signal input for receiving an input signal, a first trigger unit generating a trigger signal based upon a first trigger event in the input signal and an acquisition memory for acquiring the input signal at least based upon the trigger signal so as to provide an acquired signal. The signal processing device also comprises a second trigger unit connected to the acquisition memory. The second trigger unit is adapted to process the acquired signal according to a second trigger. The second trigger unit is adapted as a zone trigger unit applying a zone trigger. Further, a method of applying a zone trigger is described.

Abstract: A personal electronic device can include a main printed circuit board having disposed thereon a processing unit, one or more auxiliary circuits coupled to the main printed circuit board by one or more corresponding flexible printed circuits and one or more temperature sensors disposed on one of the flexible printed circuits. A processing unit of the portable electronic device can be configured to monitor the one or more temperature sensors, provide a warning in response to a monitored temperature exceeding a first threshold, and to cause a shutdown of at least a portion of the personal electronic device in response to the monitored temperature exceeding a second threshold. The temperature sensors can be negative temperature coefficient resistors.

Abstract: A modular power tile and method of operating a power distribution system includes generating a predetermined identifying pattern, by a reflectometry module of a power distribution node, injecting, by the reflectometry module, the predetermined identifying pattern, receiving, at the reflectometry module, a reflected incident signal of the predetermined identifying pattern, and scheduling a maintenance task.

Abstract: The present application provides a capacitance detection module, a method and an electronic device, including: a sensing module and detecting circuit; a first sensing unit is disposed on the first surface of the sensing module, and a second sensing unit is disposed on the second surface of the sensing module; the first sensing unit and the second sensing unit are respectively connected to the detecting circuit; the detecting circuit is configured to determine, according to the capacitance value of the first sensing unit and the capacitance value of the second sensing unit, the wearing state of the user to the device having the capacitance detection module. Thereby the problem that the capacitance detection is affected by temperature is avoided.

Abstract: A load pull system for making measurements on a DUT at millimeter wave frequencies using active tuning. The system uses phase and amplitude control of each signal at low frequency before being upconverted to the millimeter wave measurement frequencies. The measured signals at the DUT plane may be down-converted for measurement with a low frequency analyzer.

Abstract: Device for electric and magnetic measurements. In some embodiments, an electrical probe can be configured to include an unshielded inner conductor at an end of a coaxial assembly to allow an electrical field to induce differential-mode currents in the coaxial assembly. In some embodiments, a magnetic probe can be configured to include a loop connected to inner and outer conductors of a coaxial assembly to induce a common mode current by a change in magnetic field flux through the loop. In some implementations, such probes can be utilized to obtain near-field measurements to facilitate applications such as electromagnetic (EM) shielding designs.

Abstract: A wireless passive probe solves problems such as the measurement accuracy of the field strength detecting device in the prior art is affected by the communication device and the system structure is complicated, which includes a probe for collecting data in the field to be measured; wherein the wireless passive probe further comprises: a wireless transmission module, an antenna module, sensors, and a microprocessor. The wireless passive probe of the present invention transmits position temperature, field strength, moisture, air pressure probe serial numbers and the coordinate signals of the probe in real time through the wireless transmission module, and provides the power supply to the communication module through detecting or receiving microwave signals through the antenna, thereby avoiding inaccurate wireless measurement of the probe field caused by the field to be tested which is not tightly sealed and the cable.

Abstract: A wireless passive field strength probe includes monopole antennas; a detection module; a micro processing device; a wireless transmission module and an antenna module, wherein the wireless transmission module is connected to the micro processing device and the antenna module; a frequency of the antenna module is different from a frequency of the field to be measured, and is not a harmonic of the frequency of the field to be measured; and a power module connected to the detection module or the antenna module. The wireless passive field strength probe of the present invention transmits the vector electric field, the probe serial numbers and the coordinate signals of the probe in real time through the wireless transmission module, and provides the power supply to the communication module through detecting or receiving microwave signals through the antenna, thereby avoiding inaccurate wireless measurement.

Abstract: Embodiments of the present disclosure relate to in-line detection of electrical fails on integrated circuits. One embodiment is an apparatus including a device region with integrated circuits and a test region for in-line failure detection of the integrated circuits using an in-line voltage contrast test, the apparatus comprising: a substrate including a first area for the device region and a second different area for the test region; metal layers formed over both areas; wherein the integrated circuits are formed from first sections of the layers; and wherein a second section of an upper metal layer of the layers is segmented into test segments, each test segment to exhibit a predefined response during the in-line voltage contrast test depending on whether the test segment is shorted, or not, to the substrate and/or the second section of a gate layer of the layer. Other embodiments may be disclosed and/or claimed.

Abstract: Fault-type identification using composite signals composed from symmetrical component voltages and currents is described herein. Angular differences between negative-sequence composite signals and zero-sequence composite signals are used to determine a single-line-to-ground fault, and the faulted phase. Angular differences between positive sequence voltage and negative-sequence composite signals are used to determine a multiple-line-to-ground fault, and the faulted phases. Negative-sequence composite signals and zero-sequence composite signals are calculated using combinations of negative-sequence currents and voltages and zero-sequence voltages and currents, respectively.

Abstract: An arrangement for injection-based ground fault protection handling including a number of stator windings of an electric machine that are connected to a neutral point, a first transformer including at least one primary winding connected to at least one measurement point of the stator windings and at least one secondary winding for measuring an electrical quantity of the machine at the measurement point. There is also a second transformer having a primary winding connected between the neutral point and a ground potential and a secondary winding for connection to a signal generation and detection unit in order to inject a signal into the neutral point and receive a response. The impedance of the second transformer is in the range of the impedance of the machine.

Abstract: A compliant pin system includes a pin having a compliant section including a first leg and an opposing second leg. A first plurality of contact members extend along the first leg. A second plurality of contact members extend along the second leg. A pin validation system is operatively connected to the first plurality of contact members and the second plurality of contact members. The pin validation system detects a presence of an electrical signal passing between corresponding pairs of the first plurality of contact members and the second plurality of contact members to determine an integrity of the compliant pin.

Abstract: A secure distance protection for electric power delivery systems under transient conditions is disclosed herein. Upon detection of a transient condition, additional security is added to a distance protection element before a protective action is taken. The transient condition may be detected when an angle of advancement of an operating signal is outside of a predetermined threshold. An unsecure condition may also be detected before applying additional security. The unsecure condition may be detected based on an estimation of a fault within a close-in zone and a voltage magnitude falling below a threshold.

Abstract: In a method to measure changes of the pair of differential transmission lines, an in-phase signal is generated by combining first and second signals transmitted through the pair of differential transmission lines, a phase of the second signal being opposite to the first signal. In a transmission line diagnostic device, a signal combiner extracts the first and second signals received by a communication unit, combines the extracted those signals, and generates an in-phase signal, a detector detects the generated in-phase signal, and a determination unit determines an error when a magnitude of the detected in-phase signal is equal to or greater than a threshold value. In a liquid level detection device, a combining unit combines the first and second signals and generate an in-phase signal, a detection unit detects a voltage of the generated in-phase signal, and a calculation unit calculates a liquid level from the detected voltage.

Abstract: In one example, a first tubular member has a first diameter and is configured to attach to a printed circuit board. A second tubular member has a second diameter different from the first diameter and is configured to hold an environmental sensor for collecting data relating to an environment of the printed circuit board. The second tubular member is vertically adjustable relative to the first tubular member.

Abstract: A test instrument, including an embedded VNA circuit, for testing a DUT. The test instrument includes a first receiver for receiving an incident RF signal through a first coupling device; a second receiver for receiving a reflected RF signal through a second coupling device; a test port for connecting to an interconnect, which is connectable to a calibration device in a calibrating stage, during which the interconnect is characterized, and to the DUT in a testing stage, during which at least one parameter of the DUT is tested; an RF source for generating the incident RF signal during the calibrating stage; and a processing unit programmed to determine S-parameters of the interconnect based on the incident RF signal and the reflected RF signal, the S-parameters compensating for error introduced by the interconnect when testing the at least one parameter of the DUT in the testing stage.

Abstract: The present application discloses a display panel test circuit and a display panel test device, wherein the test device of the display panel test circuit controls a plurality of switching circuits to be turned on, and a signal generator controls the plurality of switching circuits to be turned off when a first metal layer and the second metal layer are short-circuited.

Abstract: A test assembly includes multiple circuit boards. Each board includes multiple pairs of contacts configurable to address the respective circuit board, an instrument, first and second headers at opposing edges of the respective board. Each pin of a first header electrically connects through the board to a corresponding pin of a second header. Each board includes first and second input/output (I/O) terminals at opposing edges of the respective board, the first I/O terminal electrically connects through the board to the second I/O terminal. A relay on the board permits the board's instrument to be activated. Each of the circuit boards mechanically and electrically connects to another circuit board through a jumper cable connecting the first header of one circuit board to the second header of another circuit board and through a conductive member electrically connecting the first I/O terminal of one board to the second I/O terminal of another board.

Abstract: A circuit board testing device electrically coupled to a measurement gauge tests a circuit board. The circuit board testing device includes a processor configured to configure measurement parameters of the measurement gauge, configure measurement rules for testing the circuit board, confirm a circuit of the circuit board to be tested according to the record of test data, control the measurement gauge to test the circuit of the circuit board to be tested when the measurement gauge is electrically coupled to the circuit of the circuit board to be tested, receive measurement data returned by the measurement gauge, and analyze a faulty region of the circuit board according to the record of test data and the measurement data.

Abstract: Systems and methods for die crack detection are disclosed. In one exemplary embodiment, a die includes a first conductive segment, an intermediate conductive segment, and a second conductive segment. The crack detection ring substantially surrounds the die according to a serpentine path having a plurality of legs, wherein each leg intersects the first conductive segment at a first intersection, an intermediate conductive segment at an intermediate intersection and a second conductive segment at a second intersection, wherein the intermediate intersection is horizontally offset from at least the first intersection and the second intersection.

Abstract: An electronic component handler including a first holding section and a second holding section holding an electronic component by adsorption, a suction section giving the first holding section and the second holding section an adsorption force to adsorb the electronic component, a suction flow path, a first branch flow path, a second branch flow path, a first opening/closing section opening and closing the first branch flow path, a second opening/closing section opening and closing the second branch flow path, a first pressure measurement section measuring first pressure inside the first branch flow path, a second pressure measurement section measuring second pressure inside the second branch flow path, and a control section, in which the control section opens the first branch flow path by the first opening/closing section and causes the first holding section to adsorb the electronic component, and checks whether or not the first pressure is lower than preset pressure when the second branch flow path is opene

Abstract: A method for scan chain testing a multi-chip module including a plurality of integrated circuit dice, some of the integrated circuit dice being of a first type and some of the integrated circuit dice being of a second type, includes separately applying a first boundary scan test stream to each die of the first type, and a second boundary scan test stream to each die of the second type. Testing apparatus includes a test interface that couples to each respective test access port, and a controller configured to separately apply the first boundary scan test stream to each die of the first type, and the second boundary scan test stream to each die of the second type. A multi-chip module includes a plurality of integrated circuit dice, each having a boundary scan register chain with a test access port, and a test access port for the module as a whole.

Abstract: Systems and methods for a lighting device are described. The lighting device can comprise a plurality of headlamps, a rechargeable battery, and a controller. The controller can be configured to perform one or more diagnostic tests.