Abstract: Continuous monitoring of acetone is a challenge using related art sensing methods. Though real-time detection of acetone from different biofluids is promising, signal interference from other biomarkers remains an issue. A minor fluctuation of the signals in the micro-ampere range can cause substantial overlapping in linear/polynomial calibration fittings. To address the above in non-invasive detection, principal component analysis (PCA) can be used to generate specific patterns for different concentration points of acetone in the subspace. This results in improvement of the problem of overlapping of the signals between two different concentration points of the data sets while eliminating dimensionality and redundancy of data variables. An algorithm following PCA can be incorporated in a microcontroller of a sensor, resulting in a functional wearable acetone sensor. Acetone in the physiological range (0.5 ppm to 4 ppm) can be detected with such a sensor.

Abstract: A liquid-sensing apparatus includes a substrate, partitions, and independent sensors. The partitions are disposed on the substrate for separating several housing spaces in order to respectively house a to-be-detected liquid, wherein each of the housing spaces has a bottom, a closed sidewall, and an open top, and thus the to-be-detected liquid may be dripped from the top of the housing space. The independent sensors are respectively formed at the bottom of different housing spaces, wherein the independent sensors respectively include different sensing material layers, and surfaces of the different sensing material layers have nanoholes.

Abstract: A gas sensor is capable of measuring the concentrations of each of a plurality of target components in a gas being measured. The gas sensor has a sensor element, and one or more processors configured to control an oxygen concentration and to acquire a target component concentration. The oxygen concentration is controlled in a first chamber and a second chamber of a first sensor cell, and the oxygen concentration is also controlled in a second chamber of a second sensor cell. The concentration of a second target component is acquired on the basis of a difference AIp between a first pump current value and a second pump current value, and the concentration of a first target component is acquired by subtracting the concentration of the second target component from the second pump current value (total concentration).

Abstract: A sensor array includes a semiconductor substrate, a first plurality of FET sensors and a second plurality of FET sensors. Each of the FET sensors includes a channel region between a source and a drain region in the semiconductor substrate and underlying a gate structure disposed on a first side of the channel region, and a dielectric layer disposed on a second side of the channel region opposite from the first side of the channel region. A first plurality of capture reagents is coupled to the dielectric layer over the channel region of the first plurality of FET sensors, and a second plurality of capture reagents is coupled to the dielectric layer over the channel region of the second plurality of FET sensors. The second plurality of capture reagents is different from the first plurality of capture reagents.

Abstract: Provided are methods and devices for the label free detection of analytes in solution, including analytes suspended in a biological fluid. A field effect transistor (FET) is positioned in close proximity to a paired set of reference electrodes and the reference electrodes electrically biased to provide desalting and a stable gate voltage to the FET. In this manner, charged ions are depleted in the sensing region of the sensor and device sensitivity to analyte detection improved by the removal of charge that otherwise interferes with measurement. Also provided are methods and systems providing increased in reference electrode surface area and/or decrease in droplet volume to further improve label-free detection of analytes.

Abstract: A wireless sensor circuit and sensor tag in which the output is directly converted to a frequency response. The sensor circuit includes a buffer transistor having gate, source and drain terminals configured as a source-follower, a gate resistor connected to the gate terminal of the buffer transistor, a supply voltage connected to the drain terminal of the buffer transistor, and an active load element and a capacitive load element connected to the source terminal of the buffer transistor. An input signal having an input frequency is applied to the buffer transistor via the gate resistor and an output signal is generated at the source terminal of the buffer transistor. The output frequency represents a response of the sensor circuit.

Abstract: An electrophoresis analyzing apparatus includes an acquisition part, an estimation part, and a correction part. The acquisition part acquires actual waveform data on electrophoresis including at least two peak waveforms partially including a superimposed portion. The estimation part estimates, based on an already-appeared peak waveform, a residual portion of an already-appeared peak waveform in the superimposed portion, the already-appeared peak waveform having appeared, in the actual waveform data, before an analysis-target peak waveform to be subjected to waveform analysis. The correction part subtracts the residual portion from the superimposed portion and corrects the analysis-target peak waveform to obtain a true analysis-target waveform.

Abstract: The invention provides methods and devices for determining the reduced ion mobility Ko of an ion species by trapped ion mobility spectrometry wherein the reduced ion mobility Ko is determined from a measured arrival time tm of the ion species and predetermined instrumental parameters by applying the inverse of a system function: Ko=SYS?1(tm,pi) or from multiple arrival times tm,i of the ion species measured for multiple values of an instrumental parameter.

Abstract: Eddy current logging enables corrosion monitoring in nested-pipe arrangements. An illustrative method of logging total thickness of the pipe walls includes acquiring measurements from an electromagnetic logging tool conveyed through the innermost bore, each measurement associated with a TRF combination (transmit antenna, receive antenna, and frequency), and further associated with a position along the bore. Multiple scale factors are applied to the measurements to determine multiple total thickness estimates for each position, each of the multiple scale factors corresponding to a subset of single-pipe defect profiles. Preferably, every possible single-pipe defect profile is included in at least one of these subsets. A total thickness log value for each position is derived from the multiple total thickness estimates for that position, and the derived total thickness log values are used to update a displayed total thickness log as the measurements are being acquired.

Abstract: Methods and systems may be configured to integrate data from fixed nondestructive inspection sensors positioned on a test specimen and data from laser ultrasound scans of the test specimen, in order to monitor and track damage and stress indications in the test specimen in real-time during mechanical stress testing of the test specimen. Data from the laser ultrasound scans may identify emergent areas of interest within the test specimen that were not predicted by stress analysis, and further allow for reconfiguration of the test plan in view of the emergent areas of interest, without having the stop the test. Laser ultrasound scans may be performed on the entire test specimen, with high-resolution scans being performed on emergent areas of interest. Thus, stress indications, or stress effects, in the test specimen may be measured, identified, and tracked in real-time (e.g., as growth is propagating) in a test specimen undergoing structural tests.

Abstract: An apparatus for in-situ calibration of a photoacoustic sensor is provided. The apparatus includes a light emitter to emit light along a transmission path to a gas and an acoustic sensor element configured to detect an acoustic signal emitted from the gas based on the received light. Furthermore, the apparatus includes a sensing unit configured to detect the light transmitted along the transmission path and to provide an output signal, and a calibration unit to receive the output signal from the sensing unit and to provide a calibration information based on the output signal received from the sensing unit.

Abstract: Certain configurations described herein are directed to gas chromatography devices. In some instances, the gas chromatography devices may comprise at least one heating device which can be moved along a chromatography column to provide a thermal gradient to the chromatography column. In other instances, the gas chromatography devices may comprise a heating device that can receive a moving chromatography column to provide a thermal gradient to the chromatography column. The gas chromatography devices may be configured as portable devices which can be used to perform remote analyses.

Abstract: A fluid analyzer having an electrical heater includes an intrinsic safety barrier that provides voltage and current from a power source to an electrical load and includes a voltage limiter and an infallible current limiting resistor for limiting the voltage and current provided to respective intrinsically safe levels, where the voltage limiter is arranged in a flameproof/explosion proof or pressurized/purged enclosure, and the current limiting resistor, e.g., an electrical heater, is connected via a connecting line to the voltage limiter and arranged outside the flameproof/explosion proof or pressurized/purged enclosure in an enclosure configured to provide protection against contact and ingress without being flameproof/explosion proof or pressurized/purged.

Abstract: A chromatography column has a column assembly that further includes a column jacket tube and a column liner tube. The column assembly is configured with end fittings that have compression limiting features and are able to withstand very high pressure, such as used in UHPLC, in conjunction with flange portions of the column liner tube that seal the column assembly. The column liner tube may be biocompatible and may have a smooth consistent inner diameter of less than 2 mm, and an inner diameter of 1 mm in particular embodiments. The end fittings for the microtube assembly may ensure durability and reliability by preventing over- or under-tightening.

Abstract: A chromatography-mass spectrometry method and apparatus of the present invention includes adding, to a sample, an internal standard material having a retention time similar to that of a target analyte and having a mass-to-charge ratio different from that of the target analyte; measuring the sample with a chromatograph-mass spectrometer and obtaining a chromatogram 101 of the target analyte and a chromatogram 102 of the internal standard material; detecting a peak 113 from the chromatogram of the internal standard material and obtaining a peak start time and a peak end time of the peak; and applying the obtained peak start time and peak end time to a peak start time and a peak end time of the chromatogram of the target analyte.

Abstract: To enable appropriate analysis to easily be performed in accordance with an object to be analyzed, provided is an apparatus for determining a chromatograph analysis method includes: an input portion (220) configured to receive input of a sample name of a sample to be analyzed and a component name; a storage (230) configured to store an analysis method for a component corresponding to the component name in the sample corresponding to the sample name so that the analysis method is associated with the sample name and the component name; and a controller (210) configured to search the storage for the analysis method, which corresponds to the sample name and the component name input to the input portion, to read the analysis method from the storage, and present the analysis method to a user.

Abstract: To make it easy to address the case in which a chromatograph does not appropriately operate.

Abstract: The present disclosure relates to a thermoplastic film that includes a layer of thermoplastic material and a color indicator applied to the thermoplastic material. The color indicator can be configured to change color in response to a trigger. For example, the color indicator can change color (e.g., change from a first color to a second color) in response to a color change trigger, such as exposure to malodor particles, absorption of moisture, a length of time, or as a result of oxidation. In one or more embodiments, the thermoplastic film further includes an odor control component configured to mask, neutralize, or otherwise control malodors. The color indicator can change its color appearance as the odor control component performs to control any present malodors, thus signaling the performance of the odor control component.

Abstract: A system includes a container to enclose vehicles within a chamber, an enclosed structure to house a canine to perform odor detection, and an air duct positioned therebetween. The container includes a first door, a second door, and a raised floor. The raised floor includes a first ramp leading to the first door, a second ramp leading to the second door, and sets of vent ducts defined between an outer wall and a top wall of the raised floor, the sets of vent ducts to direct air flow upwardly into the chamber of the container. The air duct includes a proximal end located proximate to an opening within the top wall of the container, a distal end fed through the enclosed structure to a canine-sniffing location, and one or more fan to pull air out of the chamber and deliver the air to the canine-sniffing location within the enclosed structure.

Abstract: The present invention relates to hydrogen-detectable composite particles through irreversible discoloration and a method for manufacturing same. More particularly, the present invention relates to composite particles having palladium oxide (PdO) particles adhered on the surfaces of zinc oxide (ZnO) nanoparticles and a method for manufacturing same. In addition, the present invention relates to applications of hydrogen detecting sensors, nanofibers, polymer films, paints, or the like using the composite particles.

Abstract: A sensor module includes a sensor module body, a sensing element within the sensor module body that senses a characteristic of an environment, a breathing element within the sensor module body that allows the sensing element to access the environment, electronics within the sensor module body coupled to the sensing element, and wherein the sensor module body forms a wall of a flame path.

Abstract: A method of operating a gas sensor for a gas analyte including a sensing component includes, in a first mode, interrogating the sensor by periodically applying an electrical signal to the sensing component of the sensor, measuring sensor response to the electrical signal which is indicative of a sensitivity of the sensor each time the electrical signal is applied to the sensing component, determining whether one or more thresholds have been exceeded based upon the sensor response determined each time the electrical signal is applied to the sensing component, and entering a second mode, different from the first mode in analysis of the sensor response to the periodically applied electrical signals, if one or more thresholds are exceeded.

Abstract: Undetected emissions may damage devices at a work site and pose a safety hazard to the surrounding environment. A method of control based on predictive emissions detection is disclosed. The method uses sensors coupled to work site equipment to identify devices and regions of a work site that may be affected by adverse conditions. Detection of such emissions may allow the system or operator to shut down or otherwise act on equipment before any harm is done to the device or personnel in the area.

Abstract: The present invention is related to computer implemented method for characterizing a target fluid of a hydrocarbon reservoir under uncertainty providing a set of fluid properties from a limited amount of information.

Abstract: Systems and methods for implicit chemical resolution of vacuum gas oils and fit quality determination are disclosed. The systems and methods include utilizing an FT-IR spectrum of an unknown VGO composition, and a database of FT-IR spectra of known VGO compositions, to determine a model of composition for the unknown VGO composition. Additionally, the fit quality for the model of composition is determined by performing a partial least squares analysis on specific spectral regions of interest in the FT-IR spectrum of the unknown VGO composition.

Abstract: An apparatus for detecting internal defects in a transformer is provided. The apparatus detecting internal defects that arise in the interior by integrating an electrode for electrically detecting defects and a sensor for detecting internal gas into a single body and inserting same into the interior. The apparatus for detecting internal defects in a transformer according to the present invention comprises: a metal member of a set length; a plurality of electrodes, disposed around the metal member, for detecting electrical signals generated due to internal defects of the transformer; an insulating member formed so as to contain the metal member and plurality of electrodes; and a gas sensor, installed at the end of the metal member, for detecting gas inside the transformer.

Abstract: A test cartridge includes a membrane separating an internal space of the cartridge into a sample chamber and a second chamber. A first electrode is disposed within the sample chamber, and a second electrode is disposed within the second chamber. A device includes a dock and circuitry. The dock includes a first dock-terminal and a second dock-terminal, and is configured to receive the cartridge such that the circuitry is electrically connected to the electrodes via contact between terminals of the dock and terminals of the cartridge. The circuitry performs, while the cartridge remains docked with the dock: (a) a verification step that verifies an absence of nanopores in the membrane, (b) subsequently, a nanoporation subroutine, and (c) subsequently, an assay subroutine. The circuitry enables the nanoporation subroutine only if the verification step successfully verifies the absence of nanopores. Other embodiments are also described.

Abstract: A test sensor (100) for determining an analyte concentration in a biological fluid comprises a strip including a fluid receiving area (128) and a port-insertion region (126). A first row of optically transparent (132) and non-transparent positions forms a calibration code pattern (130) disposed within a first area of the port-insertion region (126). A second row of optically transparent (142) and non-transparent positions forms a synchronization code patient (140) disposed within a second area of the port-insertion region (126). The second area is different from the first area. The synchronization code pattern (140) corresponds to the calibration code pattern (130) such that the synchronization code pattern (140) provides synchronization of the serial calibration cede pattern (130) during insertion of the port-insertion region (126) into the receiving port of the analyte meter.

Abstract: A Self Monitoring And Reporting Therapeutics SMART® composition, method, apparatus and system are provided which flexibly provide options, by combining different embodiments of the device with different embodiments of the composition, the ability to conduct definitive medication adherence monitoring over the short term (Acute Medication Adherence Monitoring, immediately up to an hour or so after taking a medication), intermediate term (Intermediate Medication Adherence Monitoring, IMAM, an hour or so to a day or so after taking a medication), and longer term (Chronic Medication Adherence Monitoring, CMAM, a day to several days after taking a medication).

Abstract: An apparatus for measuring hemolysis in a cartridge based automated blood analyzer is described. The apparatus allows hemolysis testing to be performed on a sample which is presented as a whole blood sample for other testing by the cartridge based automated blood analyzer. A disposable module is configured for optically analyzing one or more plasma analytes in a flow cell while red blood cells are acoustically separated from plasma in the flow cell.

Abstract: Provided are methods of using non-invasive assays to determine deuterium levels in a subject to effect health, disease, and athletic performance.

Abstract: Compositions, kits and methods for assessing the presence of pathological fibroblasts within a biological sample are provided. In addition, compositions, kits and methods for detecting fibrosis are provided. Also provided are methods for treating fibrosis and conditions characterized with pathological fibroblasts.

Abstract: Multiplex polymeric dye devices are provided. Aspects of the devices include a solid support, and first and second dried polymeric dye compositions distinctly positioned relative to a surface of the solid support. Aspects of the invention further include methods of making and using the devices, e.g., in analyte detection applications, as well as kits containing the devices.

Abstract: The invention provides methods for detecting small mutations and structural alterations in DNA by using binding proteins to protect those features while digesting unprotected DNA in a sample. To detect small mutations, a protein that binds exclusively to the mutation of interest, and not to wild-type, is used. For structural alterations, binding proteins are used that flank a breakpoint of the alteration. After digestion of unbound, unprotected nucleic acid in the sample, the mutation- or breakpoint-containing segment remains as an isolated DNA fragment. The sample is then assayed to detect any fragment of DNA and the detection of the fragment indicates the presence of the mutation or breakpoint in the subject.

Abstract: The present disclosure provides a method for signal amplification of electrochemical sensing of target analytes. The method includes irradiating a complex comprising a target analyte and a nanoparticle, with a light source in proximity to an electrochemical sensor. The method further includes conducting electrochemical sensing, by the electrochemical sensor, with respect to the irradiated complex to determine a presence or quantity of the target analyte. The present disclosure also provides a system for detecting a target analyte. The system includes an electrochemical sensor, a potentiostat, and a light source. The electrochemical sensor includes a plurality of electrodes and configured to perform an assay to detect a presence or quantity of a target analyte in a sample. The potentiostat is operatively coupled to the electrochemical sensor. The light source is configured to irritate a complex including the target analyte formed during the assay.

Abstract: The present invention provides QMAX based devices, kits, and methods for rapid, easy to use, and/or inexpensive detection of assaying.

Abstract: Methods, compositions, kits and systems for detecting and/or capturing a target entity in a sample. In particular, the methods, compositions and kits described herein can be used for pre-treatment of target-binding agents with a blocking agent to reduce non-target binding in a complex matrix (e.g., blood). Methods and compositions for detecting and/or capturing a microbe in a test sample, including bodily fluids such as blood and tissues of a subject, food, water, and environmental surfaces are also disclosed.

Abstract: The present invention provides a semi-quantitative phage-based assay for Mycobacterial infection, in which the phage assay plaque count correlates to the number of viable Mycobacterial organisms in the subject sample, and methods of use thereof for diagnosing, treating or monitoring Mycobacterial infection.

Abstract: An assay device is provided for use in determining the presence of a target analyte in a sample. The assay device comprises a solid platform comprising a fibrous mat, the solid platform impregnated with a first FRET chromophore. An antibody-FRET chromophore conjugate is immobilized on a surface of the solid platform, wherein the antibody-FRET chromophore conjugate comprises an antibody affixed to a second FRET chromophore. The first FRET chromophore and the second FRET chromophore are selected to provide an energy transfer from one to another when located within a Förster distance with respect to each other, thereby forming a FRET donor-acceptor chromophore pair. In a further aspect, a method of detecting a target analyte in a sample is provided. In yet a further aspect, packaging sheet materials and packaging articles employing the assay device under certain conditions are provided.

Abstract: The object is to provide a lysis method and lysis treatment solution for efficiently lysing cells of various Streptococcus bacteria in milk of a livestock animal to release a specific antigen substance contained in the cells for detecting whether causative bacterium of mastitis is a Streptococcus bacterium or not by using the milk, as well as a detection method using an immunochromatographic device. There is provided a method for lysing a Streptococcus bacterium, which comprises the step of mixing a lysis agent containing a lytic enzyme with milk obtained form a livestock animal to lyse a Streptococcus bacterium existing in the milk. The lytic enzyme is preferably at least one selected from the group consisting of lysozyme, labiase, and ?-N-acetylglucosaminidase.

Abstract: Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.

Abstract: The present invention relates an in vitro method for detecting class II restricted CD4+ T cells in a sample. Herein a sample is contacted with an isolated complex of an MHC class II molecule and a peptide. This peptide comprises an MHC class II restricted T cell epitope of an antigenic protein and immediately adjacent thereof, or separated by a linker of at most 7 amino acids a sequence with a [CST]-xx-C or C-xx-[CST] motif. CD4+ T cells are detected by measuring the binding of the complex with cells in the sample, wherein the binding of the complex to a cell is indicative for the presence of CD4+ T cells in the sample. The present invention further relates to an isolated complex of an MHC Class II molecule and a peptide comprising an MHC class II restricted T cell epitope of an antigenic protein and immediately adjacent thereof, or separated by a linker of at most 7 amino acids a sequence with a [CST]-xx-C or C-xx-[CST] motif.

Abstract: The present invention relates to a method for the absolute quantification of naturally processed HLA-restricted cancer peptides, i.e. the determination of the copy number of peptide(s) as presented per cell. The present invention can not only be used for the development of antibody therapies or peptide vaccines, but is also highly valuable for a molecularly defined immuno-monitoring, and useful in the processes of identifying of new peptide antigens for immunotherapeutic strategies, such as respective vaccines, antibody-based therapies or adoptive T-cell transfer approaches in cancer, infectious and/or autoimmune diseases.

Abstract: The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases. The present invention further relates to a method for detecting breast cancer metastasis, comprising the step of detecting at least one protein that is specific for the secretome of a chondrocyte, and for methods for treating and/or preventing breast cancer metastasis in a patient in need thereof, comprising the step of administering an effective amount of at least one ligand for one protein that is specific for the secretome of a chondrocyte to said patient in need thereof.

Abstract: The present invention relates to compositions and methods for the in vitro diagnosis of lung cancer, wherein said compositions comprise an antibody binding to progastrin and said methods comprise the use of an antibody binding to progastrin.

Abstract: Improved methods for treating lung cancer are provided. Tumor samples from patients are analyzed (i) by DNA sequencing to detect the presence of HER2 mutations and (ii) by mass spectrometric proteomic analysis to determine whether HER2 protein is expressed in the tumor cells. Patients respond to therapy with trastuzumab emtansine (T-DM1) or an equivalent antibody-drug conjugate when unique HER2 protein fragments are detected in the patient's tumor cells that harbor HER2 mutations. Conversely, patients do not respond to T-DM1 therapy when the tumor cells contain HER2 mutations but the unique protein fragments are not detected. Detection of HER3 in the tumor cells is a positive predictor of response to treatment.

Abstract: The present invention relates to methods and systems for detecting one or more analytes in a sample and/or for classifying a sample. In particular, the present invention relates to methods and systems which can be used to detect the analytes in real time and which rely on flowing through a microfluidic device one or more types of sensor molecule each comprising a domain that binds one or more analytes, a chemiluminescent donor domain and an acceptor domain, wherein the separation and relative orientation of the chemiluminescent donor domain and the acceptor domain, in the presence and/or the absence of analyte, is within ±50% of the Forster distance.

Abstract: Use of a limited digestion with a proteolytic enzyme of a multispecific antibody for the analysis of the multispecific antibody's light chain pairing.

Abstract: Methods, devices and systems for capturing biomarkers are provided. In particular, methods, compositions, and systems that utilize affinity capture devices comprising a processing chamber, affinity capture agent and porous membrane are provided.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of Metalloproteinase inhibitor 1, Metalloproteinase inhibitor 2, Metalloproteinase inhibitor 4, C—C motif chemokine 15, C—C motif chemokine 18, C—C motif chemokine 23, and/or, C—C motif chemokine 24 as diagnostic and prognostic biomarker assays in renal injuries.