Abstract: A bio-chip package comprises a substrate a first layer over the substrate comprising an image sensor. The bio-chip package also comprises a second layer over the first layer. The second layer comprises a waveguide system a grating coupler. The bio-chip package also comprises a third layer arranged to accommodate a fluid between a first-third layer portion and a second-third layer portion, and to allow the fluid to pass from a first side of the third layer to a second side of the third layer. The third layer comprises a material having a predetermined transparency with respect to a wavelength of a received source light, the waveguide system is configured to direct the received source light to the grating coupler, and the image sensor is configured to determine a change in the wavelength of the source light caused by a coupling between the source light and the fluid.

Abstract: The present technology includes a color changeable indicator that changes color upon exposure of the indicator to high pressure and comprises at least one reagent releasing layer, a transition layer disposed on the reagent releasing layer, a color changeable layer disposed on the transition layer, and a non-porous protectant encompassing the reagent releasing layer, the transition layer and the color changeable layer. An additional reagent releasing layer can be located between the transition layer and the color changeable layer. The indicators provide simple, reliable, and cost effective detection means for detecting whether a product has been exposed to high pressure, e.g. high pressure pasteurization, and may find use in applications such as food and beverage processing and/or packaging and medical applications.

Abstract: Embodiments of the present disclosure provide for methods of detecting, sensors (e.g., chromogenic sensor), kits, compositions, and the like that related to or use tunable macroporous polymer. In an aspect, tunable macroporous materials as described herein can be used to determine the presence of a certain type(s) and quantity of liquid in a liquid mixture.

Abstract: A colorimetric sensor for drugs and an associated method provide for delivery of particles to the sensor and a colorimetric reagent containing element having a plurality of dyes structured to provide a color change when the airborne particles indicate the presence of fentanyl or fentanyl analogues. The color change may be monitored by an optical identifier which delivers responsive information to a programmable controller which, in turn, may activate a visual alarm or an audible alarm.

Abstract: A remote illumination and detection method, node, and system is described. The remote illumination and detection method generates a detection message when motion is detected by a detector. The detector includes a wireless communications module that wirelessly transmits the detection message to a remote sensing device. The remote sensing device includes a camera having a field of view and wirelessly communicates with the detector. The remote sensing device then proceeds to generate an illumination instruction to illuminate an area within the field of view, when the remote sensing device receives the detection message. The remote sensing device transmits the illumination instruction to an illuminator. The illuminator wirelessly communicates with the remote sensing device. The method then illuminates an area near the illuminator, when motion is detected by the detector and the illumination instruction is received by the illuminator.

Abstract: A multi-functional precious stone testing apparatus includes a portable housing, a testing unit, and an indication unit. The portable housing includes a hand-held casing and a probe casing extended from a front end of the hand-held casing. The testing unit includes a conductive probe, a sensor, and a UV light source for emitting UV light beam, so as to allow the sensor to sense the UV reflected and refracted by a testing object for determining various qualities of the testing object.

Abstract: Structural health monitoring (SHM)/nondestructive evaluation (NDE) exists as a tool in conjunction with manufactured pieces. Presently disclosed subject matter integrates automated video with a structural health monitoring system. In conjunction with bridge monitoring, integration of such two systems automates determination of the effect or correlation of vehicular loading on SHM data from a subject bridge. Such correlations help to understand the sources of structural health monitoring data, particularly acoustic emission data, in bridges and other structures, such as dams and nuclear plants. Automation of the evaluation of bridges and other structures increases accuracy and minimizes risk to workers and the public. Assessing the structural condition of bridges and other structures as presently disclosed also facilitates automated asset management of transportation systems, such as by state departments of transportation and other bridge/structural owners.

Abstract: The automatic inspection machine for containers and contents thereof, comprises a serial horizontal conveyor line of the containers oriented with a vertical axis through at least one inspection station comprising lighting means of the containers, at least one television camera for acquiring images of the illuminated containers, the lighting means comprising a first, a second and at least a third lighting device.

Abstract: This disclosure relates to a method for security inspection of baggage and/or personal items. This disclosure also relates to a kit of parts with a detachable single-use inlay and an X-ray tray of a security check at an airport.

Abstract: Disclosed is an image displaying apparatus, including: a hardware processor that: acquires a series of frames of a dynamic image from a radiographic imaging apparatus that generates the series of frames at a predetermined imaging frame rate based on received radiation; stores the acquired series of frames in a storage; selects frames to be used for display from the series of frames stored in the storage by picking up a frame from every predetermined number of frames; and displays an edited dynamic image composed of the selected frames on a display.

Abstract: An X-ray inspection system is presented. The X-ray inspection system comprises an X-ray source, an X-ray scintillator, a light detector, a first objective lens, and a second objective lens. The first objective lens is positioned between the X-ray scintillator and the light detector. The second objective lens is positioned between the first objective lens and the light detector.

Abstract: A method of using the transverse relaxation rate (R2) of solvent NMR signal to noninvasively assess alum-containing products such as vaccines. This technique can be used for quality control in vaccine manufacturing (e.g., fill-finish step) to determine the evenness of alum filling level as well as extent of alum particle sedimentation in filled and sealed products.

Abstract: A temperature control device and a temperature control method for use in measuring thermal properties of materials at high and low temperatures are disclosed herein. The temperature control device is configured for controlling a temperature of a test volume inside a test cell and is capable of providing both extremely high and low test volume temperatures over a wide temperature range. The temperature of the test volume is controlled using opposing heating and cooling by controlling a supply of thermal energy to the test cell from a heating subsystem while simultaneously removing thermal energy from the test cell using a cooling subsystem.

Abstract: A test system and method for thermoelectric module. The test system includes an electrical performance test unit, a heat flux detection unit, and a processor. The electrical performance test unit connects with the thermoelectric module under power generation state to test output power of the thermoelectric module and working current and internal resistance under this output power. The heat flux detection unit includes a heat flux sensor installed at a cold-end of the thermoelectric module to detect the heat flux. The processor electrically connects with the electrical performance test unit and the heat flux detection unit to calculate the thermoelectric conversion efficiency ? of thermoelectric module. By using the technical scheme of the invention, the detection of the thermoelectric conversion efficiency of the thermoelectric module is accomplished.

Abstract: An integrated circuit includes a bi-directional signal transmission pin connected to a sensing electrode of a salinity sensor, an RF interface which generates operating voltages on the basis of an RF signal received through an antenna, different types of driving signal generators having a structure in which each output terminal is connected to the pin, different types of analog-to-digital converters having a structure in which each input terminal is connected to the pin, and a microcontroller unit which generates a first control signal and a second control signal according to a type of the salinity sensor, in which one of the different types of driving signal generators is enabled based on the first control signal, one of the different types of analog-to-digital converters is enabled based on the second control signal, and the operating voltages are supplied to an enabled signal generator and an enabled analog-to-digital converter.

Abstract: Systems and methods for detecting defects in pipelines are disclosed. In one embodiment, a method for detecting defects in pipelines includes: generating an electrical signal in a first pipeline by a signal generator electrically connected with the first pipeline and a second pipeline. A reflected signal is acquired by data acquisition equipment electrically connected with the first pipeline and the second pipeline. The reflected signal at least partially reflects from a defect in the first pipeline or the second pipeline. The method also includes analyzing the reflected signal to determine at least one of a location of the defect and a severity of the defect. In some embodiments, the first pipeline and a second pipeline are connected with a shunt cable.

Abstract: The present disclosure is directed to a gas sensor that includes an active sensor area that is exposed to an environment for detection of elements. The gas sensor may be an air quality sensor that can be fixed in position or carried by a user. The gas sensor includes a heater formed above chamber. The gas sensor includes an active sensor layer above the heater that forms the active sensor area. The gas sensor can include a passive conductive layer, such as a hotplate that further conducts and distributes heat from the heater to the active sensor area. The heater can include a plurality of extensions. The heater can also include a first conductive layer and a second conductive layer on the first conductive layer where the second conductive layer includes a plurality of openings to increase an amount of heat and to more evenly distribute heat from the heater to the active sensor area.

Abstract: According to at least one aspect of the present disclosure, a reference half-cell for an electrochemical sensor for measuring a medium is disclosed. The reference half-cell includes a housing defining a chamber containing an electrolyte, the housing including a wall having an aperture therethrough, and an electrode disposed in the electrolyte in the chamber. The reference half-cell further includes a reference junction disposed in the aperture such that an interface between the reference junction and the housing wall is impermeable. The reference junction is electrically or ionically conductive and impermeable to the measured medium and the electrolyte, and the reference junction enables a constant potential at the electrode. An electrochemical sensor and oxidation-reduction potential sensor employing the reference junction are also disclosed.

Abstract: Methods and apparatuses for selective monitoring of multiple silicon compounds in etchant solutions are provided. Methods can include reacting a test solution comprising a plurality of different silicon compounds with a fluoride-based compound in several conditions to provide different silicon:reagent binding ratios. One of the conditions can include the addition of a co-solvent to the test solution. Concentrations of the multiple silicon compounds can be determined based on the different binding ratios of silicon:reagent. Methods can further include a measuring method such as silicon elemental analysis or measuring of functional groups of a certain silicon form of a first portion of a test solution comprising a plurality of different silicon compounds and reacting a second portion of the solution with a fluoride-based compound to provide a silicon:reagent binding ratio. Concentrations of the multiple silicon compounds can be determined based on the measuring method and binding ratio measurements.

Abstract: An isotachophoresis (ITP) apparatus having a first zone configured to contain a solution comprised of a trailing electrolyte (TE); a second zone configured to contain solution containing a leading electrolyte (LE); a flow channel connecting the first zone and the second zone; and a first filter having a pore size sufficient to entrap an analyte, the first filter being integrated within the first zone, and in fluid communication with the flow channel, wherein the flow channel is in a distinct direction with respect to the filtration flow, is disclosed herein. A system comprised of a microfluidic device comprised of a flow channel is further disclosed. A method of electrophoresis-sample preparation is further disclosed herein.

Abstract: Devices and methods for characterization of analyte mixtures are provided. Some methods described herein include performing enrichment steps on a device before expelling enriched analyte fractions from the device for subsequent analysis. Also included are devices for performing these enrichment steps.

Abstract: A sampling tube bundle includes a tube bundle body and a joint assembly. The tube bundle body includes a gas sampling tube for transmitting sampling gas; a metal woven layer wrapping an outer circumference of the gas sampling tube; a heating pad comprising a heat tracing cable wrapping an outer circumference of the metal woven layer, for heating the sampling gas in the gas sampling tube; a flame resistant tape wound around an outer circumference of the of the heating pad; a plurality of signal transmission lines circumferentially spaced apart from one another are arranged outside the flame resistant tape; and a sheath located outside the signal transmission line. The joint assembly is arranged on an end of the tube bundle body, for connecting to an analysis device or a sampling device.

Abstract: A spray area in which a large number of droplets of a liquid sample sprayed from a spray nozzle (3) is separated from the tip of a needle electrode (14) for corona discharge by a sufficiently large distance, with a grid electrode (15) facing the needle electrode (14) placed in between. Ring electrodes (16) for creating an electric field which drives primary ions that should react with the sample and generate sample-derived ions are provided within an ion chamber (10) between the grid electrode (15) and the spray area. Primary ions generated by corona discharge within the space between the needle electrode (14) and the grid electrode (15) pass through the opening of the grid electrode (15), reach the spray area under the effect of the electric field, and ionize sample components. Since the droplets are prevented from adhering to the needle electrode (14), the corona discharge is maintained in a stable state. The resultant primary ions are efficiently transported and used for the ionization of the sample.

Abstract: A photo acoustic non-destructive measurement apparatus and method for quantitatively measuring texture of a liquid. The apparatus includes a laser generating tool, an acoustic capturing device, and a data processing unit. The laser generating tool directs a laser towards a surface of a liquid contained in a container and creates pressure waves that propagate through the air and produce an acoustic signal. The acoustic capturing device records and forwards the signal to a data processing unit. The data processing unit further comprises a digital signal processing module that processes the received acoustic signal. A statistical processing module further filters the acoustic signal from the data processing unit and generates a quantitative acoustic model for texture attributes such as hardness and fracturability. The quantitative model is correlated with a qualitative texture measurement from a descriptive expert panel. Textures of liquids are quantitatively measured with the quantitative acoustic model.

Abstract: The invention comprises methods for fabricating and using a plurality of sensors on a substrate surface, such as ultrasonic sensor probes. The methods for fabricating sensors directly on the substrate surface includes the use of a template to dispose sensor material in an array and form a first layer on the substrate surface and a second template to dispose sensor electrode material in a corresponding array to form a second layer on top of the first layer. The invention provides a sensor housing that electrically connects the sensors and a computing device. The sensor housing may comprise a flexible circuit having a plurality of sensor electrode contact points corresponding to each of the sensors, at least one spring plate, a force distribution plate, and a plurality of cable wires attached to the flexible circuit and corresponding to each of sensor electrode contact points.

Abstract: A gas sensor including a gas sensing device having a resonant frequency that varies with adsorbed chemicals, a frequency detector configured to detect the resonant frequency of the gas sensing device, a calibrator configured to generate current calibration data based on the resonant frequency of the gas sensing device which has been heated to a calibration temperature in a calibration mode, and a compensator configured to adjust an output value of the frequency detector based on the current calibration data in a sensing mode may be provided.

Abstract: A transducer complex includes a resonator for enhancing an output and a measurement sensitivity of a guided wave transducer. The transducer complex includes: an ultrasonic transducer attached onto a surface or inserted into an object, the ultrasonic transducer having a longer length in parallel with the surface of the object than a length in a direction perpendicular to the surface of the object and the ultrasonic transducer receiving electric power from an external power source to generate ultrasonic waves or receiving ultrasonic waves from outside to generate electricity; and the resonator attached to the object or the ultrasonic transducer or inserted into the object, the resonator being symmetrically arranged in parallel on the outside of the ultrasonic transducer to be adjacent to the ultrasonic transducer.

Abstract: A process is disclosed in which a computing device reads electronic data from an ultrasonic scanning probe and processes that data in real time to determine if any potential weld defects are encountered as the probe head moves along scanning the weld. The method receives weld scan data in the form of scanning slices and determines if any of the encountered indications match a predetermined criterion. The process utilizes a moving scan data window of scan slices and processes each window for indications of weld defects. The processing of the data window is optimized using a rule-based, indications counting set so that any found defect indications triggers the issuance of a signal to an operator, in various forms, such as activating a marking module, issuing an alert signal, or printing a report.

Abstract: A sample injection device is provided with a syringe for injecting a sample and an arrangement unit in which plural kinds of cleaning solvents are arranged to clean the syringe. The device is configured to be able to set a cleaning order of the syringe by the plural kinds of cleaning solvents.

Abstract: A confirmation ion ratio allowable value calculation unit calculates a confirmation ion ratio allowable value when a target ion and confirmation ions are interchanged based on a preset confirmation ion ratio allowable value, and a peak identification processing unit identifies mass peaks of the target ion and the confirmation ions based on the confirmation ion ratio allowable value. A peak waveform processing unit calculates peak areas of the target ion and the confirmation ions, and a calibration curve creation unit creates calibration curves for quantification based on the target ion and the confirmation ions from a peak area of a target compound included in a standard sample. A quantitative value calculation unit obtains quantitative values while referring to a calibration curve corresponding to a peak area for a target compound included in an unknown sample. A quantitative analysis result display processing unit displays the quantitative values and chromatogram peak waveforms.

Abstract: A remote sensor calibration system remotely calibrates sensors of various types in an automated fashion. The remote sensor calibration system receives sensor output, associated with one or more locations and one or more times, from a sensor and its peer sensor population. The sensor output from the sensor and its peer sensor population is compared to generate a correction factor. The correction factor is transmitted to the sensor and used to calibrate the sensor. Communication will typically occur via one or more wireless links allowing the sensors to be remotely calibrate while maintaining their mobility.

Abstract: Disclosed is a colorimetric gas sensor using a complex polymer nanofiber structure for yarn-based gas indication, in which ionic liquids as effective gas adsorbents and color change dyes having varying colors have been functionalized in a nanofiber and a method of fabricating the same. In the fabrication method, after the ionic liquids and color change dyes are mixed with a polymer solution in which high-temperature stirring and quenching processes are accompanied to prepare fine crystals of color change dyes. Accordingly, the dual-electro-spinning process is conducted to produce the nanofiber yarn scaffold on which ionic liquids and color change dyes are finely functionalized.

Abstract: The present disclosure relates to methods, devices, and systems for measuring nitric oxide released from a material. For example, a method of measuring nitric oxide release from a material can include introducing a continuous flow of a carrier gas into a sample holding chamber via a carrier gas inlet at an effective flow rate, introducing an amount of the nitric oxide releasing material into the sample holding chamber via a separate sample inlet to contact the continuous flow of the carrier gas, directing the carrier gas and released nitric oxide out of the sample holding chamber via a nitric oxide outlet toward a nitric oxide detector, and quantifying an amount of released nitric oxide using the nitric oxide detector.

Abstract: A method for detecting a state of an egg, the method comprising: illuminating an egg with a plurality of light pulses, each one of said plurality of light pulses having: a wavelength between about 400 nanometer (nm) and about 1500 nm, a width between about 0.5 picoseconds (ps) and about 500 ps, and an intensity between about 0.1 milliJoule (mJ) and about 100 mJ; capturing a reflection of at least a portion of the plurality of light pulses at a time delay corresponding to light reflected from within said egg in an interval of between about 1 mm and about 20 mm; analyzing the captured reflection to determine at least one spectrum of each of said plurality of light pulses; and classifying at least one of a gender and a fertility state of said egg according to said at least one spectrum.

Abstract: The present invention provides a method for diagnosing a disease or disorder selected from the group consisting of insulin resistance, a metabolic disorder, diabetes and pre-diabetes in a subject. The method comprises the step of determining the level of a compound represented by structural formula (VI): or a salt thereof. Compositions and method of making thereof are also described.

Abstract: An in vitro method for identifying an anti-cancer agent, the therapeutic efficacy of which is enhanced upon administration with a second agent that increases the expression of OPRK1 and/or BAD, comprising the steps of: a. co-incubating a population of cells with a target anti-cancer agent and said second agent and b. measuring the cytotoxicity and/or cytostasis in the population of cells; wherein the therapeutic efficacy of the target anti-cancer agent is enhanced if the cytotoxicity and/or cytostasis of the target anti-cancer agent is increased compared to a control.

Abstract: The present invention relates to a system for screening personalized anticancer agents, a method for screening personalized anticancer agents using the system, and an apparatus for screening personalized anticancer agents. When the inventive system for screening personalized anticancer agents is used, an anticancer agent showing an optimal anticancer activity against cancer cells collected from a patient can be selected from a variety of anticancer agents, and it is possible to previously examine a therapeutic response that can appear when the selected anticancer agent is administered into the patient. Thus, the risk of trial and error in cancer therapy can be reduced, and the cost and time required for cancer therapy can be reduced.

Abstract: The present invention relates to imaging methods to assess the efficacy of anticancer drugs in vitro using spontaneously-forming spheroids.

Abstract: Provided herein, in some embodiments, are methods for modifying expression and/or activity of genes associated with renal disease. Also provided herein are methods for identifying agents that modify expression and/or activity of genes associated with renal disease.

Abstract: A living tissue model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a cell layered body disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. A vascular wall model includes: a porous membrane having a honeycomb structure; a vascular endothelial cell layer disposed on one face of the porous membrane; and a smooth muscle cell layer, or a mesenchymal stem cell layer, disposed on another face of the porous membrane. A vascular wall model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a vascular wall model disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. Applications of these models or model devices are also provided.

Abstract: The present disclosure provides a blood vessel model including: a pair of channel members, mutually opposing each other, each of which includes an opposing face in which a respective microchannel is formed; and a porous membrane that includes plural through-holes penetrating in a thickness direction, that is disposed between the opposing faces of the pair of channel members, and that partitions between the microchannels, wherein the porous membrane is provided with a vascular endothelial cell layer so as to cover one face facing one of the microchannels, an average opening diameter of the through-holes is from 1 ?m to 20 ?m, and an opening coverage ratio of the through-holes is from 30% to 70%.

Abstract: The present invention relates to a method for determining the fertility of spermatozoa, said method comprising determining the total content of Vimentin variant 3 (Vim3) per spermatozoon and/or the spatial localization of the Vim3 in the spermatozoa, wherein a decreased amount of total content and/or decreased amount of (or even missing) accumulation of Vim3 in the mid piece of the spermatozoa indicates decreased fertility. Further, the present invention refers to a dipstick usable for this method. Moreover, the present invention relates to further methods and uses in the context of the present invention.

Abstract: Provided are methods and articles of manufacture for use with cell therapy for the treatment of diseases or conditions, e.g., cancer, including for predicting and treating a toxicity. In some embodiments, the toxicity is a neurotoxicity or cytokine release syndrome (CRS), such as a severe neurotoxicity or a severe CRS. The methods generally involve detecting a marker by assaying a biological sample from a subject that is a candidate for treatment, optionally with a cell therapy, to determine if the subject is at risk for developing the toxicity, such as neurotoxicity or CRS or severe neurotoxicity or severe CRS. In some embodiments, the methods and articles of manufacture further includes a regent for assaying the biological sample and instructions for determining the percentage or number of cells positive for the marker in the biological sample.

Abstract: An electric field stirring apparatus, in which a droplet as a liquid disposed between a first electrode and a second electrode disposed to face each other is vibrated and stirred by an electric field generated between the first electrode and the second electrode, the second electrode having a groove formed along a first direction on an electrode surface facing the first electrode, includes a movement mechanism that reciprocally moves the first electrode relative to the second electrode in a second direction intersecting the first direction in a state in which the first electrode and the second electrode face each other during a period in which the electric field is generated.

Abstract: A system and method includes a test container for detecting a target substance in a consumable sample, where the test container includes a test container body defining a test container top, a test container bottom opposing the test container top, a first chamber proximal the test container top, and a second chamber proximal the test container bottom, a magnetic diaphragm situated between the first chamber and the second chamber, the magnetic diaphragm obstructing flow of the consumable sample, and the magnetic diaphragm including a magnetic element embedded in the magnetic diaphragm, and a driving element geometrically complementary to the first chamber, the driving element including a consumable sample grinding feature protruding from a surface of the driving element.

Abstract: A molecular recognition element comprising a target molecule-recognizing portion, and a direct electron transfer-type oxidoreductase linked to the target molecule-recognizing portion.

Abstract: The present invention provides microfluidic pScreen™ devices for quantifying the concentration of DNA fragments in a liquid sample by using magnetic-responsive silica micro-beads and nonmagnetic-responsive silica micro-beads. The devices of the present invention allow for rapid, simple and inexpensive quantification of DNA fragment concentration in a sample. The devices do not require complex instrumentation and can be performed in less than three minutes. Moreover, they are compatible with complex samples including, without limitation, unpurified PCR amplification products, and thus can be expected to seamlessly integrate into various common molecular biology techniques and workflows.

Abstract: The present disclosure relates to an apparatus and a method for extracting genome, capable of acquiring a sufficient amount of genome for genetic analysis with high extraction efficiency, even with a small amount of target sample.

Abstract: Provided herein are compositions and methods for identifying one or more targeted nanoparticles suitable for delivery to one or more organs or tissues of a subject.

Abstract: Provided is a convenient measurement system by which a target to be detected can be quickly recognized with high specificity. This base material for manufacturing a sensor for analyzing a detection target has: a base material; and a polymer film provided on the surface of the base material, wherein the polymer film has a concave that receives the detection target, and the concave has an antibody material bonding group and a signal material bonding group. A sensor for analyzing a detection target has: the base material for manufacturing a sensor for analyzing a detection target; an antibody material specific to the detection target and bonded to the antibody material bonding group; and a signal material that is bonded to the signal material bonding group.