Patents Issued in April 30, 2020
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Publication number: 20200132667Abstract: It is provided a measuring cartridge (1) for measuring at least one constituent of a liquid sample, in particular blood, and for performing quality control, the cartridge comprising: a casing (3) insertable into a reception opening (51) of a measuring instrument (50), the casing (3) at least partly surrounding an inner space (5); wherein the inner space contains: a measurement cell (7) comprising a reception space (9) for the sample and at least one sensor area (11) with which the sample is in contact when loaded into the reception space (9); plural quality control containers (13a,13b,13c) for respectively holding different quality control solutions (15a,15b,15c); a solution routing system (17) adapted to selectively route one of the quality control solutions (15a,15b,15c) from the respective quality control container (13a,13b,13c) into the reception space (9) of the measurement cell (7).Type: ApplicationFiled: October 28, 2019Publication date: April 30, 2020Inventors: Wolfgang HOFMANN, Wolf-Dietrich STEINBĂ–CK, Josef HINDINGER
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Publication number: 20200132668Abstract: A device is presented for storing, transporting, measuring, and collecting blood, having the properties of a precisely determined volume, the ability to be emptied or filled while connected to a continuous source (such as a supply of a drug, or the bloodstream of a patient), and a geometry suitable for the entire device to be placed in the counting chamber of a detector (such as the counting well of a gamma counter).Type: ApplicationFiled: October 30, 2019Publication date: April 30, 2020Applicant: DAXOR CORP.Inventors: Jonathan Feldschuh, Ronald Cacheiro
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Publication number: 20200132669Abstract: A method for detecting a gaseous substance in a gas-mixture, a first measuring-variable which represents a first chemical and/or physical parameter of the gas-mixture being acquired, at least one second measuring-variable which represents a second chemical and/or physical parameter of the gas-mixture that differs from the first parameter being acquired, and a starting-measuring-instant, corresponding to the starting-instant, of the first parameter is specified when an amount of a time-derivative of the first measuring-variable exceeds a first predefined threshold-value and an amount of a time-derivative of the second measuring-variable exceeds a second predefined threshold-value, and at least one further first measuring-variable is acquired, an end instant is specified when the at least one further first measuring-variable corresponds to the starting measuring-variable, and an output signal is generated when the amount of a difference between the end instant and the starting instant is greater than a predefinType: ApplicationFiled: April 20, 2018Publication date: April 30, 2020Inventors: Rajeev H. Venkatesh, Mary Thomas, Ye Lu
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Publication number: 20200132670Abstract: The present invention relates to a fatty liver and liver fibrosis evaluation system based on impedance. The fatty liver and liver fibrosis evaluation system based on impedance provided in one aspect of the present invention uses 3-dimensional liver microtissues so that the fatty liver formation and the stiffness changes resulted from liver fibrosis induced by a test drug can be analyzed with non-invasive and highly reproducible manner.Type: ApplicationFiled: April 24, 2019Publication date: April 30, 2020Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Jung-Hwa Oh, Jaehwan Ahn, Seokjoo Yoon, Jun-Ho Ahn, Heeyoung Yang, Hyoung-Yun Han
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Publication number: 20200132671Abstract: The invention relates to methodologies of obtaining a controlled exposure of an aerosol to a model material. The invention also provides an exposure cap and a system for studying or predicting the interaction between a model material, e.g. a cell, and an aerosolized agent. The controlled exposure of the aerosol to the model material, makes is possible to accurately calculate the mass-balance of the aerosol exposure.Type: ApplicationFiled: December 20, 2019Publication date: April 30, 2020Inventor: Per GERDE
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Publication number: 20200132672Abstract: A method, a composition and a kit for screening an ALK or ROS-1 kinase inhibitor are disclosed in the present specification. In an aspect, by the method, composition and kit for screening an ALK or ROS-1 kinase inhibitor according to the present disclosure, it is possible to conduct simultaneous quantitative and qualitative analysis and faster screening of a larger number of candidate substances as compared with conventional molecular biological experimental methods and to grasp the overall level of change in a plurality of different metabolites in a cell line by candidate substances of ALK or ROS-1 kinase inhibitor and thus the screening efficiency for drugs which exert an ALK or ROS-1 kinase inhibitory effect is excellent. Consequently, the present disclosure has an advantage of being able to be used in various ways in the development of new drugs which exert an ALK or ROS-1 kinase inhibitory effect.Type: ApplicationFiled: May 10, 2019Publication date: April 30, 2020Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Byung Hwa JUNG, Hyun Beom LEE, Naeun YOON
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Publication number: 20200132673Abstract: Provided herein are methods to identify agents or compounds that specifically modulate the oligomerization and/or functional activities of receptor protein tyrosine phosphatase sigma (RPTP?) in an abnormal fibroblast cell and therapies based therefrom.Type: ApplicationFiled: March 24, 2018Publication date: April 30, 2020Inventors: Nunzio Bottini, Eugenio Santelli, Christian Secchi
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Publication number: 20200132674Abstract: Disclosed are methods of detecting abnormal expression of one or more genes associated with a neurological disease such as the Alexander disease, the Alzheimer's disease, the Parkinson disease, the Huntington disease, multiple sclerosis, and amyotrophic lateral sclerosis. The methods include performing a transcriptome analysis of the astrocytes derived from a patient and the astrocytes derived from a healthy control subject, thereby to determine one or more genes that are substantially differentially expressed. Also disclosed are methods of treating a neurological disease by correcting the abnormally expressed genes associated with the neurological disease.Type: ApplicationFiled: July 8, 2019Publication date: April 30, 2020Inventors: Yanhong Shi, Li Li
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Publication number: 20200132675Abstract: A point-of-care testing (POCT) quantitative pathogen detection device is provided, without the aid of any detectors. In an illustrative embodiment, a POCT pathogen detection device includes an inlet microwell for receiving a substance, the inlet microwell connected to a distribution channel to distribute the substance to an analyzing component. The device also includes an analyzing component. that includes a first pathogen detection component. The first pathogen detection component includes a platinum nanoparticle-labeled magnetic DNA-probe configured to propel a dye through a bar-chart channel when a pathogen in the substance reacts platinum nanoparticle-labeled magnetic DNA-probe. The platinum nanoparticle-labeled magnetic DNA-probe is configured to react with a first pathogen.Type: ApplicationFiled: July 17, 2019Publication date: April 30, 2020Inventors: XiuJun Li, Delfina Dominguez, Xiafeng Wei
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Publication number: 20200132676Abstract: Systems and methods are provided for analyzing blood of a living being, and for presenting guidance for medical treatment.Type: ApplicationFiled: October 30, 2019Publication date: April 30, 2020Applicant: DAXOR CORP.Inventor: Jonathan Feldschuh
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Publication number: 20200132677Abstract: Systems and methods are provided for measuring blood volume of a living being.Type: ApplicationFiled: October 30, 2019Publication date: April 30, 2020Applicant: DAXOR CORP.Inventors: Jonathan Feldschuh, Ronald Cacheiro
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Publication number: 20200132678Abstract: A method for characterizing the interaction between a protein and a small molecule by detecting a change in fluorescence emitted by a fluorescent dye and a nucleic acid structure which can be used in said method.Type: ApplicationFiled: June 21, 2018Publication date: April 30, 2020Applicant: Dynamic Biosensors GmbHInventors: Hanna Beike, Herwin Daub, Ismajli Fjolla, Andreas Langer, Ulrich Rant, Ralf Strasser
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Publication number: 20200132679Abstract: The present invention provides a membrane carrier 3 comprising a flow path 2 and a detection zone 3y, wherein a microstructure is provided at the bottom of the flow path 2 and a mean surface roughness of the microstructure is 0.005 to 10.0 ?m.Type: ApplicationFiled: March 28, 2018Publication date: April 30, 2020Applicant: Denka Company LimitedInventors: Shuhei AOYAMA, Kenji MONDEN
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Publication number: 20200132680Abstract: Determining the relative binding capacity of albumin (A), and amount of functional albumin, involves at least two measurement solutions of a test and reference sample. The measurement solutions contain an albumin-binding marker M. The marker in the measurement solution of the test and reference samples exceeds the presumed available albumin binding capacity. The test sample contains a defined amount of albumin of unknown binding capacity. The reference sample contains the same defined amount of albumin having a reference binding capacity. The measurement solutions are incubated under conditions that allow M:A complexes to form. The M:A complexes are removed. The presence or amount of unbound marker M in the solutions is detected after M:A complex removal by a test strip that allows determination of the unbound marker. The relative binding capacity of albumin in the test sample based on the presence or detected amounts of unbound marker is determined.Type: ApplicationFiled: April 20, 2018Publication date: April 30, 2020Inventors: Sebastian KLAMMT, Steffen MITZNER, Jan STANGE, Emil REISINGER
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Publication number: 20200132681Abstract: 2-dimensional surfaces modified with elastin-like polymer (ELP) that transitions between states in the presence of one or more analytes are described. This transition can be monitored to identify the presence and concentration of the one or more analytes. 2-dimensional surfaces of the present disclosure may also or alternatively be configured such that when an analyte binds to ELP on the 2-dimensional surface, such binding changes a degree at which the ELP responds to various non-analyte stimuli (e.g., pH, temperature, etc.). In such examples, the 2-dimensional surface may detect the presence of analyte based on the how the ELP responds to the non-analyte stimuli. For example, ELP on a 2-dimensional surface may transition between states at a first temperature when analyte is not present (e.g., bound to the ELP). The temperature at which the ELP transitions may change based on how much analyte (e.g., what concentration of analyte) is present.Type: ApplicationFiled: October 30, 2019Publication date: April 30, 2020Inventors: Jeffrey M. Halpern, Eva M. Balog
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Publication number: 20200132682Abstract: Disclosed herein are methods and kits for isolating and/or quantifying exosomes in a sample. For example, the exosomes are isolating using lectin-modified magnetic beads suspended in an exosome-free buffer, and the exosome-bead complexes are isolated from the remainder of the mixture using a magnetic field. For separating the exosomes from the exosome-bead complexes, an elution buffer having a pH value of 6.8 to 7.6 is used, thereby avoiding the convention elution steps involving acidic or alkaline reagents. For quantification, the exosome-bead complexes, as isolated, are subject to subsequent flow cytometry.Type: ApplicationFiled: March 20, 2018Publication date: April 30, 2020Applicants: Biovesicle Inc.Inventors: Dapi Meng Lin CHIANG, Michael W. PFAFFL, Dominik BUSCHMANN
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Publication number: 20200132683Abstract: A method for diagnosing Parkinson's and Alzheimer's disease without invasive techniques or complicated wet-laboratory equipment. The method utilizes the rapid detection of both the CD38 protein and alpha-synuclein protein at a specific concentration that reflects the pathological state of Parkinson's disease, and CD38 protein and the tau protein which are found in significantly elevated concentrations in blood plasma and serum in the disease states. The blood plasma or serum can be collected and utilized as the test material for the pre- and post-symptom Parkinson's disease and Alzheimer's disease.Type: ApplicationFiled: October 25, 2019Publication date: April 30, 2020Inventors: Mark Wasserman, Todd Flower
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Publication number: 20200132684Abstract: A method of detecting bio-material includes preparing an electrode where capture structures are fixed on surface of the electrode; preparing nanoparticles where probes are fixed on surfaces of the nanoparticles; providing bio-materials on the nanoparticles so that the probes of a portion of the nanoparticles make complementary bonds with the bio-materials, respectively, to form composites, and another portion of the nanoparticles remain without making bonds with the bio-materials; and providing another portion of the remaining nanoparticles on the surface of the electrode so that the capture structures make complementary bonds with the probes of another portion of the nanoparticles, respectively, wherein each of the capture structures includes nucleotides having first sequence, each of the probes includes nucleotides having second sequence, each of the bio-materials includes nucleotides having third sequence, the first and second sequences are complementary to each other, and the second and third sequences arType: ApplicationFiled: October 30, 2019Publication date: April 30, 2020Inventors: Young Jun KIM, Bongjin JEONG
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Publication number: 20200132685Abstract: Disclosed herein are methods and systems for the detection of an analyte of interest by an amplified assay. The method and systems of the invention utilize the high specificity of biomolecules that have been coupled to a solid support to further amplify a signal produced by the interaction of a binding agent with the analyte of interest as a means to detect low levels of the analyte of interest present in a sample. In certain embodiments, for immunochemical (for example, ELISA or RIA) or immunofluorescence assays in which a protein to be identified is bound directly or through capture antibodies to a passivated surface, amplification of Ëś10,000-fold can be achieved.Type: ApplicationFiled: August 21, 2019Publication date: April 30, 2020Applicant: Laboratory Corporation of America HoldingsInventors: Dwight Lyman Anderson, Andrew J. Conrad, Stephen Erickson, Ben Barrett Hopkins
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Publication number: 20200132686Abstract: The invention relates to assays, devices and kits for accurate determination of neutralizing antibodies levels in samples of a subject suffering from an immune-mediated disorder, treated with biological drugs, and for predicting responsiveness to the drug in these patients.Type: ApplicationFiled: January 9, 2020Publication date: April 30, 2020Inventors: Yehuda CHOWERS, Sigal PRESSMAN, Alexandra BLATT, Shiran GERASSY-VAINBERG
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Publication number: 20200132687Abstract: Provided are novel methods for screening and testing for pathogens in food, water, and bodily fluids using methods that are faster to complete than conventional methods of culturing and plating that require lengthy times in properly equipped labs. The invention utilizes specific, rapid and sensitive optical detection to capture small concentrations of the target bacteria and render them amenable for detection with various specific synthesis binding agents approaches. The technique merges capture and detection steps with quantification unit suitable to provide results in a relatively shorter time current detection methods.Type: ApplicationFiled: October 31, 2019Publication date: April 30, 2020Inventor: Majed El-Dweik
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Publication number: 20200132688Abstract: Provided are a marker for detecting a highly pathogenic influenza virus including a protein mutant prepared by substituting the amino acids 68 and 69 of a PB1-F2 protein, a composition for detecting a highly pathogenic virus including an agent for measuring the protein mutant, and a detection kit including the same, a method for detecting a highly pathogenic virus including measuring the protein mutant, an antiviral composition against influenza A virus including an inhibitor of binding between a PB1-F2 protein in which the amino acids 68 and 69 are substituted and DDX3, and a method for screening an antiviral substance against influenza A virus.Type: ApplicationFiled: November 29, 2017Publication date: April 30, 2020Applicant: Dandi Bioscience IncInventors: Kyun-Hwan KIM, Eun Sook PARK, Yeong-Min PARK, Baik Lin SEONG, Young Ho BYUN, Hye Min LEE
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Publication number: 20200132689Abstract: The present disclosure is directed to methods (e.g., in vitro methods) for use of nicotinamide phosphoribosyltransferase (NAMPT) as a biomarker in radiation-induced lung injury (RILI). Provided herein is an in vitro method for the diagnosis, prognosis, and/or monitoring of RILI in a human subject by providing a tissue or plasma sample from the subject and detecting the level of NAMPT therein, wherein a higher level of NAMPT in the tissue or plasma sample from the subject compared to a healthy control or a reference value is indicative for the presence of RILI in the subject. Further provided herein is a method of detecting NAMPT in a human subject by obtaining a biological sample from the subject, detecting the presence of NAMPT in the sample by contacting the sample with a capture agent that specifically binds NAMPT, and detecting binding between NAMPT and the capture agent.Type: ApplicationFiled: October 31, 2019Publication date: April 30, 2020Inventor: Joe G.N. Garcia
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Publication number: 20200132690Abstract: An aqueous composition includes (i) glutamate dehydrogenase from a bacterium of the Clostridium genus, (ii) a stabilizing compound that is a carboxylic acid having a carbon-based chain of at least three carbon atoms and comprising at least two —COOH groups, or a salt thereof, and (iii) any of a monosaccharide polyol, disaccharide polyol, or polymeric macromolecule in addition to the glutamate dehydrogenase. A process for stabilizing the glutamate dehydrogenase in order to maintain antigenic properties of the glutamate dehydrogenase includes stabilizing the glutamate dehydrogenase in the aqueous composition and maintaining the antigenic properties of the glutamate dehydrogenase during storage of the aqueous composition.Type: ApplicationFiled: January 3, 2020Publication date: April 30, 2020Applicant: BIOMERIEUXInventors: Florence BETTSWORTH, Jérôme MARTINEZ
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Publication number: 20200132691Abstract: Described herein are methods and compositions for treating cancer. Aspects of the invention relate to administering to a subject an agent that inhibits the activity, level, and/or migration of a SiglecFhigh cell. Another aspect of the invention relates to first identifying a population of SiglecFhigh cells in a patient and then administering an agent to the patient that inhibits the activity, level, Sand/or migration of said population of SiglecFhigh cells. In one embodiment, the patient has lung cancer.Type: ApplicationFiled: April 24, 2018Publication date: April 30, 2020Applicants: THE GENERAL HOSPITAL CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Mikael PITTET, Camilla ENGBLOM, Christina PFIRSCHKE, Allon M KLEIN
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Publication number: 20200132692Abstract: Embodiments of the disclosure relate to a screening method for the diagnosis of haematological neoplasia. In the method, a first test step is performed to check whether a potential haematological neoplasia exists. At least a first haematogram is created with a blood sample in the first test step. Based on a first set of filter rules, it is checked whether the first haematogram differs from a desired state specified according to the first set of filter rules, and a second test step is performed to check for potential haematological neoplasia if the first test step reveals that there is potential haematological neoplasia. In addition, the disclosure relates to a system, a computer program product, and a computer-readable storage medium.Type: ApplicationFiled: December 26, 2019Publication date: April 30, 2020Applicant: Bioscientia Institut fĂĽr Medizinische Diagnostik GmbHInventor: Wolfgang Kaminski
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METHODS FOR TARGET DNA DETECTION USING NON-FUNCTIONALIZED CARBOHYDRATE-CAPPED METALLIC NANOPARTICLES
Publication number: 20200132693Abstract: The disclosure relates to a method for specific detection of a target analyte using probe DNA specific to the target analyte and non-functionalized, carbohydrate-capped metal nanoparticles such as non-functionalized, dextrin-capped gold nanoparticles. A sample mixture including a target DNA analyte and a probe DNA specific thereto is incubated to from a probe DNA-target DNA complex. The non-functionalized, carbohydrate-capped metal nanoparticles and an ionic species such as sodium chloride or other salt are added to the probe DNA-target DNA complex, and the mixture is incubated. Addition of the ionic species creates a detectable distinction, such as color of the resultant mixture, between stabilized metal nanoparticles when the probe DNA-target DNA complex is present and destabilized metal nanoparticles when the probe DNA-target DNA complex is absent. The method can be used for colorimetric detection of plant pathogens and associated diseases in agricultural production systems.Type: ApplicationFiled: March 16, 2018Publication date: April 30, 2020Inventors: Robert Day, Amy Baetsen-Young, Evangelyn C. Alocilja -
Publication number: 20200132694Abstract: The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the tumor necrosis factor receptor superfamily member 8 protein (CD30) that are particularly advantageous for quantifying the CD30 protein directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring (SRM) mass spectrometry, or what can also be termed as Multiple Reaction Monitoring (MRM) mass spectrometry. Such biological samples are chemically preserved and fixed wherein the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.Type: ApplicationFiled: January 11, 2017Publication date: April 30, 2020Inventors: David B. Krizman, Todd Hembrough, Wei-Li Liao
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Publication number: 20200132695Abstract: The invention relates to a method of preparing a biological sample for study in an analysis device, said method comprising the steps of: providing a biological material to be studied; providing a sample holder that is configured to be placed in said analysis device; and transferring said biological material onto said sample holder for preparing said biological sample. According to the invention, the method comprises the steps of: acquiring a specimen of said biological material provided on said sample holder; transferring said specimen to a screening device for screening said specimen; and evaluating said biological sample based on results obtained by said screening device. With the method, time and resources may be more effectively used in studying biological samples, for example using charged particle microscopy in the form of cryo-EM.Type: ApplicationFiled: September 24, 2019Publication date: April 30, 2020Applicant: FEI CompanyInventor: Albert Konijnenberg
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Publication number: 20200132696Abstract: Methods are provided for detecting and quantifying the DLL1, DLL3, JAG1, JAG2, Notch1, Notch 2, Notch 3, Notch 4, and/or DLL4 proteins in biological samples, such as a formalin fixed paraffin embedded tissue samples, using mass spectrometry. Additionally, methods are provided for treating cancer based upon the level of the DLL1, DLL3, JAG1, JAG2, Notch1, Notch 2, Notch 3, Notch 4, and/or DLL4 proteins in the biological samples.Type: ApplicationFiled: October 29, 2019Publication date: April 30, 2020Inventors: Todd HEMBROUGH, Fabiola CECCHI, Sarit SCHWARTZ, Kerry SCOTT
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Publication number: 20200132697Abstract: Methods and system for identifying and/or quantifying a protein are provided herein.Type: ApplicationFiled: October 30, 2019Publication date: April 30, 2020Inventors: Yuetian Yan, Shunhai Wang
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Publication number: 20200132698Abstract: Methods of detecting ZNT8 antibodies in serum are described. The methods include proteoliposomes comprising a transmembrane domain (TMD) and a cytosolic domain (CTD) of ZnT8 proteins exposed on the exterior of the proteoliposome; serum comprising antibodies targeting the ZnT8 proteins; and labelled captured autoantibodies that bind to ZnT8 antibodies.Type: ApplicationFiled: July 5, 2018Publication date: April 30, 2020Inventors: Dax Fu, Chengfeng Merriman, Hongjie Dai, Hao Wan
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Publication number: 20200132699Abstract: The invention relates to methods of diagnosis, control and prophylaxis of inflammation and mitigation of inflammatory conditions, particularly arthritis and joint pain, in canines, comprising measuring inflammatory biomarkers wherein elevated levels of the biomarkers in blood correlates to reduced inflammation and reduced levels in blood correlates to increase level in the tissues. The invention further provides a method to treat or control inflammation comprising administering a diet comprising increased levels of one or more of DHA, EPA, vitamin C, vitamin E, and/or L-carnitine.Type: ApplicationFiled: January 2, 2020Publication date: April 30, 2020Applicant: Hill's Pet Nutrition, Inc.Inventor: Nolan FRANTZ
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Publication number: 20200132700Abstract: Methods for predicting post-transfusion survival of red blood cells are provided herein. In some versions, the methods include measuring a level of lysophospholipids in a unit of red blood cells and predicting the post-transfusion survival of the red blood cells in the unit based on the measured level of lysophospholipids.Type: ApplicationFiled: May 4, 2017Publication date: April 30, 2020Applicant: BLOODWORKSInventors: James Charles Zimring, Xiaoyun Fu
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Publication number: 20200132701Abstract: Provided are devices systems and methods for evaluation of hemostasis. In some embodiments, an apparatus is disclosed comprising a housing, a plurality of test chambers located in the housing, the plurality of test chambers including chambers configured for measurements via a system that interrogates one or more viscoelastic properties of test samples in the test chambers, wherein the one or more viscoelastic properties is used to characterize dynamics of coagulation and/or fibrinolysis.Type: ApplicationFiled: October 21, 2019Publication date: April 30, 2020Inventors: Francesco Viola, William F. Walker, Gregory V. Browne, Robert S. Magyar, Bjarne Hansen, Christopher G. Denny
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Publication number: 20200132702Abstract: Described herein are methods for determining the overall survival of maintenance hemodialysis patients. The methods include measuring low density lipoprotein (LDL) particle size and subfraction concentrations as prognostic tools for early mortality risk detection. For example, the presence of increased very small LDL concentration or decreased LDL particle size in blood-serum serves as a useful means for prognostic risk assessment and monitoring.Type: ApplicationFiled: October 29, 2019Publication date: April 30, 2020Applicants: Quest Diagnostics Investments LLC, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)Inventors: Kamyar Kalantar-Zedeh, Michael P. Caulfield, Wael A. Salameh
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Publication number: 20200132703Abstract: Assay systems including assay apparatus and handheld assay devices for use therewith for obtaining diagnostic information of a bodily specimen. Assay devices include a cartridge housing snugly accommodating a specimen slide intended for elevation from an initial lowermost specimen introduction position to a final uppermost specimen examination position in which a bodily specimen is compressed between a cartridge housing top face and a specimen slide. Assay devices preferably include a liquid reagent dispensing arrangement for dispensing liquid reagent on a specimen slide for reacting with a bodily specimen.Type: ApplicationFiled: December 23, 2019Publication date: April 30, 2020Inventors: Menachem LEV-SAGIE, Nimrod LEV, Tal SHLOMOVITZ, Zohar HOROWITZ LIMOR
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Publication number: 20200132704Abstract: The present invention discloses a spectral-potentiometric-thermometric multi-dimensional titration analysis instrument, which comprises a spectral titration measurement device, a thermometric titration measurement device and a potentiometric titration measurement device which are arranged in parallel, meets the simultaneous measurement requirements of different analysis methods in chemical analysis, improves the measurement precision of different measurement methods, and effectively reduces the workload of separate experiments. The present invention further provides a usage method of the analysis instrument, provides analysis results of different angles and different characterization parameters for the change process of the material structure in the chemical reaction by conducting comparison analysis on data obtained using different measurement techniques, and effectively reduces the workload of titration analysis.Type: ApplicationFiled: December 23, 2019Publication date: April 30, 2020Inventor: Fei WANG
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Publication number: 20200132705Abstract: The present invention relates to systems and methods of determining quality compliance for a set of biological sample testing devices used with one or more test instruments at the point-of-care in a hospital or other location that delivers medical care. In particular, the systems and methods ensure that only biological sample testing devices that pass a quality assurance protocol are used for point-of-care testing.Type: ApplicationFiled: December 23, 2019Publication date: April 30, 2020Applicant: Abbott Point of Care Inc.Inventors: Paul Glavina, Jody Ann Tirinato
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Publication number: 20200132706Abstract: Disclosed is an automatic cleaning and separating device for removing uncombined components in reactants in a reaction container. The automatic cleaning and separating device includes: a liquid injection and uniform mixing mechanism, a removal assembly and a liquid suction mechanism; wherein a liquid injection driver is mounted on the liquid injection and uniform mixing mechanism, a liquid suction driver is mounted on the liquid suction mechanism, the liquid injection driver drives the liquid injection and uniform mixing mechanism to move up and down so as to complete liquid injection, the liquid suction driver drives the liquid suction mechanism to move up and down to complete liquid suction, and the removal assembly removes the reaction container from the liquid injection and uniform mixing mechanism under the relative motion of the liquid suction mechanism and the liquid injection and uniform mixing mechanism.Type: ApplicationFiled: December 26, 2017Publication date: April 30, 2020Inventor: Zhen ZHANG
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Publication number: 20200132707Abstract: A wash system for use in an in vitro diagnostic immunoanalyzer utilizes a bridge having a linear track to move cuvettes from one incubation ring portion to another incubation ring portion. Washing stations along the linear track provide a magnetic field and fluid washing of cuvette contents independent of the size and motion of one or more incubation rings.Type: ApplicationFiled: June 22, 2018Publication date: April 30, 2020Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Ayman Ismail, Eric Gerolstein, Brian Bolger
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Publication number: 20200132708Abstract: The invention relates to an arrangement for preparing a plurality of samples for an analytical method, comprising a carousel with a solid housing and moveable receiving parts for the sample containers; a control for controlling the receiving parts in the carousel; and a sample receiving device for providing the sample for the analytical method. Said arrangement is characterized in that one or more stations for preparing samples are provided on the carousel, the receiving parts for the sample containers of the carousel can be positioned on said stations. Said arrangement also comprises a centrifuge with pairs of opposite lying receiving parts provided for the sample containers, and said receiving parts are arranged such that they can move on the centrifuge for the sample holder such that a transfer of a sample holder between a receiving part in the carousel and a receiving part in the centrifuge can be carried out. The control takes place by the same control which is also provided for controlling the carousel.Type: ApplicationFiled: December 23, 2019Publication date: April 30, 2020Inventor: Joachim Gerstel
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Publication number: 20200132709Abstract: The invention relates to an arrangement for preparing a plurality of samples for an analytical method, comprising a carousel with a solid housing and moveable receiving parts for the sample containers; a control for controlling the receiving parts in the carousel; and a sample receiving device for providing the sample for the analytical method. Said arrangement is characterized in that one or more stations for preparing samples are provided on the carousel, the receiving parts for the sample containers of the carousel can be positioned on said stations. Said arrangement also comprises a centrifuge with pairs of opposite lying receiving parts provided for the sample containers, and said receiving parts are arranged such that they can move on the centrifuge for the sample holder such that a transfer of a sample holder between a receiving part in the carousel and a receiving part in the centrifuge can be carried out. The control takes place by the same control which is also provided for controlling the carousel.Type: ApplicationFiled: December 23, 2019Publication date: April 30, 2020Inventor: Joachim Gerstel
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Publication number: 20200132710Abstract: There is provided a dispensing unit capable of alleviating the load on a dispensing unit and other components at the time of a collision while maintaining the vibration-suppressing function. Also, an automated analyzer having this dispensing unit is provided. The dispensing unit has a dispensing probe, a drive mechanism, an arm member, a first probe holder, a second probe holder, a first support spring, second support springs, and vibration dampers. The second probe holder is supported to the first probe holder so as to be movable vertically and holds the dispensing probe. The second support springs bias the second probe holder against the first probe holder and in combination have a spring constant smaller than that of the first support spring. The vibration dampers are bridged from the arm member to the second probe holder.Type: ApplicationFiled: October 28, 2019Publication date: April 30, 2020Inventor: Mizuki Nakamura
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Publication number: 20200132711Abstract: The accelerometric sensor has a suspended region, mobile with respect to a supporting structure, and a sensing assembly coupled to the suspended region and configured to detect a movement of the suspended region with respect to the supporting structure. The suspended region has a geometry variable between at least two configurations associated with respective centroids, different from each other. The suspended region is formed by a first region rotatably anchored to the supporting structure and by a second region coupled to the first region through elastic connection elements configured to allow a relative movement of the second region with respect to the first region. A driving assembly is coupled to the second region so as to control the relative movement of the latter with respect to the first region.Type: ApplicationFiled: December 23, 2019Publication date: April 30, 2020Inventors: Alessandro TOCCHIO, Francesco RIZZINI, Carlo VALZASINA, Giacomo LANGFELDER
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Publication number: 20200132712Abstract: A method for indicating impact of external shocks on an electronic device and the electronic device thereof are provided. An operating method of the electronic device includes monitoring shock related information due to an external force, calculating a shock amount and a shock position based on the shock related information, and calculating a shock state of a component in the electronic device based on the shock amount and the shock position.Type: ApplicationFiled: October 25, 2019Publication date: April 30, 2020Inventors: Taekeun KIM, Kihoon KANG, Shinyoung NA, Kihun EOM, Jeongmin PARK
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Publication number: 20200132713Abstract: An inertial sensor includes a substrate, a movable element having an edge, and a suspension system retaining the movable element in spaced apart relationship above a surface of the substrate. The suspension system includes an anchor attached to the surface of the substrate, the anchor having a first side laterally spaced apart from the edge of the movable element, and a spring structure having a first attach point coupled to the first side of the anchor and a second attach point coupled to the edge of the movable element. The spring structure includes beam sections serially adjoining one another, the beam sections extending from the first side of the anchor and surrounding the anchor to couple to the edge of the movable element. The spring structure makes no more than one coil around the anchor to position the first attach point in proximity to the second attach point.Type: ApplicationFiled: October 31, 2018Publication date: April 30, 2020Inventor: Andrew C. McNeil
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Publication number: 20200132714Abstract: The physical quantity sensor includes a substrate of which thickness direction is in the direction along the Z axis, and a sensor element provided on the substrate to detect a physical quantity, wherein the sensor element includes a movable part which is displaced in a direction along the X axis that is an axis for measuring the physical quantity with respect to the substrate, and a fixed electrode fixed to the substrate, and the movable part includes a movable electrode disposed to face the fixed electrode in the direction along the X axis, and a mass portion that supports the movable electrode and has a longer length than the movable electrode in a direction along the Z axis.Type: ApplicationFiled: October 28, 2019Publication date: April 30, 2020Inventor: Yoshiyuki MATSUURA
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Publication number: 20200132715Abstract: An acceleration sensor includes a base substrate provided with a first recess part, and a sensor part located on the first recess part and swingably supported in a depth direction of the first recess part by a support part, wherein the sensor part is sectioned into a first part and a second part by the support part, includes a movable electrode part in the first part and the second part, a through hole is provided at least at an end side in the second part larger in mass than the first part, and the base substrate includes a fixed electrode part in a position opposed to the movable electrode part in the first recessed part, and a second recess part deeper than the first recess part is provided in a position opposed to the end side of the sensor part.Type: ApplicationFiled: December 31, 2019Publication date: April 30, 2020Inventor: Mitsuhiro YODA
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Publication number: 20200132716Abstract: Microelectromechanical system (MEMS) accelerometers are described. The MEMS accelerometers may include multiple proof mass portions collectively forming one proof mass. The entirety of the proof mass may contribute to detection of in-plane acceleration and out-of-plane acceleration. The MEMS accelerometers may detect in-plane and out-of-plane acceleration in a differential fashion. In response to out-of-plane accelerations, some MEMS accelerometers may experience butterfly modes, where one proof mass portion rotates counterclockwise relative to an axis while at the same time another proof mass portion rotates clockwise relative to the same axis. In response to in-plane acceleration, the proof mass portions may experience common translational modes, where the proof mass portions move in the plane along the same direction.Type: ApplicationFiled: October 25, 2018Publication date: April 30, 2020Applicant: Analog Devices, Inc.Inventor: Xin Zhang