Abstract: An apparatus for storing blood plasma separated after fractionation from whole blood within a wrapped hematocrit (capillary) tube. The apparatus is large enough to receive and display a standard laboratory identification label. The apparatus stores plasma from a hematocrit tube that does not include thixotropic gel. The apparatus housing has an intended upright orientation, a central axis, a top end, a bottom end, and side walls defining an internal cavity. A wall with an upper surface and a lower surface divides the internal cavity into an upper cavity and a lower cavity. A reservoir is formed in the upper cavity. A removable cap seals the reservoir. The cap is movable between open and closed positions. A channel within the lower cavity extends axially from the bottom of the housing to the wall. The channel receives and supports the wrapped hematocrit tube while plasma is expelled therefrom and into the reservoir.

Abstract: A package that is configured to store and dispense fluids. The package includes a container and a dosing dispenser for closing an opening to the container. The dosing dispenser includes a closure removably coupled to the container and an anti-suction valve fixed to the container that is configured to minimize formation of a complete seal between a user's mouth and an upper surface of the anti-suction valve so that sufficient suction to remove fluid from the container is blocked.

Abstract: Some embodiments disclosed herein relate to a device for transferring precise amounts of fluid from at least one source container to at least one target container. In some embodiments, the fluid is first transferred from the source container (e.g., a vial) through a connector to an intermediate measuring container (e.g., a syringe). In some embodiments air can pass through an air inlet and enter the vial to compensate for the volume of fluid withdrawn from the vial. An air check valve or a bag or a filter can prevent the fluid from escaping through the air inlet. The precisely measured amount of fluid can then be transferred from the intermediate measuring container to the target container (e.g., an IV bag). In some embodiments the connector can include a source check valve and a target check valve to direct fluid first from the source container to the intermediate measuring container and then from the intermediate measuring container to the target container.

Abstract: The invention relates to a set of scales and to an installation for producing a medical composition using a set of scales. The set of scales comprise interchangeable securing means for a target container, the weight thereof being measured by the set of scales.

Abstract: The invention relates to a method and a system for synthesizing a medical preparation, a peristaltic pump being used for pumping liquid from a plurality of source containers. According to the invention, micro-amounts are extracted only in the linear region of the peristaltic pump.

Abstract: An automated medication dosing and dispensing system includes: gesture sensors to detect physical movement of a user; a measurement sensor to generate sensor data indicative of a physiological characteristic of the user; a measurement sensor processor to process the sensor data generated by the measurement sensor; computer-readable storage media comprising program code instructions; and at least one processor.

Abstract: A system, device, and method for dispensing a topical medication to an animal are described. The system includes a computing device and a collar. The computing device includes information related to a treatment program for dispensing a topical medication. The collar includes a container configured to store a topical medication, a microdispenser positioned on an inside surface of the collar and fluidly connected to the container, wherein the microdispenser is configured to deliver bursts of the topical medication over a period of time, and a controller operably connected to the microdispenser.

Abstract: A pill dispending canister mountable onto a pill packaging device comprising a hopper, a bulk dispenser, and a discrete dispenser. The hopper preferably includes a reservoir and an initial passage. The bulk dispenser preferably includes a bulk dispensing base, a bulk dispensing disc, a bulk dispensing motor, a pill exit chute, and bulk dispensing sensor. The discrete dispenser preferably includes a discrete dispensing base, a pill sorter, a discrete dispensing disc, a discrete dispensing motor, a pill drop chute, a pill jam sensor, a discrete pill sensor, a pill gate, a gate motor, and a control board.

Abstract: Nipple shields can be used by breastfeeding mothers to facilitate the feeding process. The disclosed embodiments relate to nipple shields with a port through which liquid supplement can flow from a supply tube into an interior section of the shield. The liquid supplement can be drawn through ports in a tip of the shield in order to augment a naturally expressed flow of milk. A flap of material is bonded to an interior portion of the nipple shield over an optional channel formed in the interior portion so as to form a closed, flap-covered channel leading from an input port on a lower portion of the shield to a an interior location near the tip of the shield.

Abstract: A nasogastric tube structure is disclosed which comprises a first tube, a clamping member and a positioning member. The first tube has a front necking opening, a rear opening, a stopper ring on a wall thereof adjacent to the rear opening and an engaging groove on the wall thereof adjacent to the stopper ring. The clamping member comprises two corresponding positioning segments and a C-shaped clip portion for connecting the two positioning segments and engaging with the engaging groove. The positioning member is sleeved on the two positioning segments.

Abstract: A dental pulp capping composition can comprise a particulate base material which is non-toxic, and capable of forming a structural capping matrix; and a particulate setting material which is non-toxic, water-soluble, biocompatible, and capable of setting the composition. Optional growth factors can also be introduced into the composition to facilitate dental tissue repair. A complimentary method of restoring damaged tooth features can comprise removing diseased and/or damaged portions of the tooth to expose a prepared tooth region. Water can be added to the dental pulp capping composition to form a workable coherent paste. The workable coherent paste can be introduced into the prepared tooth region. The workable coherent paste can then be shaped within the prepared tooth region and then set to form a rigid biomimetic structure within the prepared tooth region.

Abstract: The described invention relates, in part, to a water-free, toothbrush-free oral composition in the form of a tablet, comprising neem, xylitol, one or more polymers, optionally magnolia bark extract, and a coating, wherein the tablet is activated in situ by a chewing action and/or by contacting saliva, and methods of use.

Abstract: A first problem is to provide a novel technique for forming hyaluronan into particles. Further, a second problem is to provide a novel technique suitable for production of a composite particle containing an anionic polymer and a peptide. Means for solving the first problem is a composite particle containing an anionic polymer, and a cationic polymer (except for chitosan) having a degree of cationization of 0.2 or more. Means for solving the second problem is to mix an anionic polymer and a peptide in an aqueous solvent having a pH of 5 or less.

Abstract: The invention relates to a foam formulation comprising an emulsion, comprising an oil phase and a water phase, the oil phase comprising at least one membrane-forming substance forming a lamellar membrane in the foam formulation.

Abstract: The present invention relates to an emulsifying combination, a composition comprising this combination, and the use of this emulsifying combination in small quantities to obtain a low viscosity water-in-oil emulsion.

Abstract: The method for making a nanoemulsion is described. The method uses a neutralized fatty acid and does not require traditional surfactant in order to yield stable nanoemulsion having a diameter from 70 to 550 nm.

Abstract: A method and apparatus, for treating plaque and calculus in the mouth cavity—particularly on teeth—are disclosed. The apparatus—and accordingly the method—is comprised of introducing at least one first-component comprising a material with a redox potential for preventing anions precipitation; and introducing at least one second-component comprising a material with a redox potential for preventing cations precipitation.

Abstract: The present disclosure relates to a cosmetic composition comprising a cosmetically acceptable carrier and at least 2.5% by weight of calcined kaolin relative to the total weight of the composition. It also relates to a cosmetic method for reducing the gloss of the skin and to the use of calcined kaolin as a mattifying agent in a cosmetic composition.

Abstract: Described herein, an anhydrous cosmetic composition includes one or more water-absorbing components; a malodour-controlling component; a cosmetically acceptable carrier; wherein the anhydrous cosmetic composition has a burst resistance pressure greater than about 137.9 mBar (2 psi); wherein the anhydrous cosmetic composition has a water vapor sorption per 100 g of the composition from about 2.0 g to about 15 g; and wherein the anhydrous cosmetic composition is essentially free of aluminium-based antiperspirant actives.

Abstract: A cosmetic kit includes a skin staining composition of (i) a monovalent salt of alginic acid, a water-soluble colorant, and water and (ii) an activating composition of water and a cosmetically acceptable salt of calcium or magnesium. Also disclosed is a method for cosmetically treating or making up the human skin by using the cosmetic kit useful in making up lips, eyelids and eyebrows.

Abstract: The aspects presented herein provide methods and compositions for the reduction of the peroxide value of perfume ingredients, formulated perfumes, formulated body care products, essential oils, and natural extracts.

Abstract: A hair dyeing method including the following steps (I) and (II): step (I): mixing a first agent comprising an alkaline agent and an oxidation dye precursor, a second agent comprising an oxidizing agent, and a third agent comprising one or more dyes (A) selected from the group consisting of the following (A-1), (A-2), and (A-3), having a pH at 25° C. of 7.5 or more and 12 or less when diluted to be 10 times by mass with water; and step (II): applying a mixed solution prepared in step (I) on hair.

Abstract: A liquid hair dye composition, comprising components (A) and (B), wherein the content (X) of component (A) in the composition is 1.5 mass % or more and 9.3 mass % or less, the content (Y) of component (B) in the composition is 9 mass % or more and 98.5 mass % or less, and the liquid hair dye composition satisfies the following formula (1) (with the proviso that a liquid hair dye composition which has the content of diol of 50 mass % or more and the content of water of 2 mass % or less is excluded), Y?10.875X?10.875 (1), (A) an azo dye of the formula (A-1), and (B) a monoalcohol and/or a diol other than alkanolamines.

Abstract: The invention provides compositions and methods for topically inhibiting, reducing or preventing growth or biofilm formation of caries-, gingivitis- and/or halitosis-causing bacteria. The composition includes at least about 0.005% (w/v) of tea polyphenols, a pH modulating agent for maintaining a pH of the composition above about 6.5, and at least about 1% (w/v) of a 3-carbon to a 24-carbon sugar alcohol. Also provided are food products or supplements incorporating such compositions.

Abstract: A melanogenesis inhibitor combination is provided, comprising: a combination of (Z)—N-(4-hydroxybenzylidene)propan-2-amine oxide; and a compound of formula I wherein R1 and R2 are independently selected from a hydrogen atom and an acyl group having 3 to 20 carbon atoms; wherein the combination is dispersed in a dermatologically acceptable carrier.

Abstract: Described herein are oral care compositions comprising a deoxy sugar antimetabolite and methods of inhibiting microbial biofilm formation and/or degrading a microbial biofilm in a subject.

Abstract: The disclosure provides methods of enhancing hair growth and hair follicle restoration using a siRNA or shRNA directed against a human Fidgetin like-2 nucleic acid. Specifically, the disclosure provides compositions comprising siRNA or shRNA against a human Fidgetin like-2 nucleic acid, and the methods of using the compositions. Further disclosed are siRNA sequences against a human Fidgetin like-2 nucleic acid and the formulations of the compositions.

Abstract: A device and protective composition is described that is used in the context of first aid for skin contact with acids, bases, oxidizing agents, formaldehyde and fluorides serving to neutralize and inactivate the chemicals. The device comprises a two-chamber applicator that contains a first preparation in a first chamber, such as an antioxidant, and a second preparation in a second chamber, such as a solution that contains a buffer and a calcium salt. The two preparations are mixed just before application and are applied to the affected areas by the device.

Abstract: Described herein, an anhydrous cosmetic composition includes a first water-absorbing component having a water vapor sorption greater than about 20 g per 100 g of the first water-absorbing component according to the Water Vapor Sorption Test Method as disclosed herein; a second water-absorbing component having a water vapor sorption from about 8.5 to about 19.9 g per 100 g of the second water-absorbing component according to the Water Vapor Sorption Test Method as disclosed herein; a malodour-controlling component; a cosmetically acceptable carrier; and wherein the anhydrous cosmetic composition is essentially free of aluminum-based antiperspirant actives.

Abstract: A hair care composition is disclosed comprising a copolymer, an ethoxylated alkyl sulfate anionic surfactant having a formula RO(CH2CH2O)nSO3M, wherein R is an alkyl or alkenyl having from 8 to 18 carbon atoms; M is a solubilising cation comprising sodium, potassium, ammonium or mixtures thereof; the degree of ethoxylation n is 2, and from 0.

Abstract: A cosmetic mask composition including a combination of acrylates/VA copolymer and acrylates copolymer. The cosmetic mask composition includes about 5% to 30% by weight of acrylates/VA copolymer, and about 0.2% to 2% by weight of acrylates copolymer. The ratio of acrylates/VA copolymer to acrylates copolymer is in the range of 15:1 to 25:1.

Abstract: Described herein, an anhydrous cosmetic composition includes a first water-absorbing component comprising a mixture of a superabsorbent polymer and a polyquaternium; a second water-absorbing component selected from the group consisting of starch particles, a stearate component, and mixtures thereof; a malodour-controlling component; a cosmetically acceptable carrier; and wherein the anhydrous cosmetic composition is essentially free of aluminum-based antiperspirant actives.

Abstract: An oil-in-water-type emulsion cosmetic contains an ultraviolet ray scattering agent and which has preparation stability in a system where a water-soluble alkyl-substituted polysaccharide derivative and another emulsifying agent coexist is further improved. The oil-in-water-type emulsion cosmetic containing (A) a water-soluble alkyl-substituted polysaccharide derivative, (B) a nonionic surfactant and (C) an ultraviolet ray scattering agent, wherein the blend ratio [(A)/(B)] of the water-soluble alkyl-substituted polysaccharide derivative (A) to the nonionic surfactant (B) is 1.54 or less, and the blend ratio [(A)/(C)] of the water-soluble alkyl-substituted polysaccharide derivative (A) to the ultraviolet ray scattering agent (C) is 0.02 or less.

Abstract: A transparent personal cleansing composition for skin and hair care comprises non-ionic and anionic surfactants with hydrophobe of lauryl group in the vegetable oil which exhibit enhanced foaming and lather capacity in comparison to the marketed products. The personal care composition of the present invention avoids harsh or toxic anionic ether sulphate type surfactants, eco-toxic non-ionic fatty alcohol ethoxylates, fatty alkanol amides and a host of other ingredients that are not derived from renewable sources.

Abstract: The invention relates to a dosage form for an active ingredient, to be dissolved in the oral cavity, comprising a first film layer and a second film layer that is arranged over the first film layer, wherein the composition of the first film layer can be identical to that of the second and comprises a water-soluble polymer, said first and the second film layers being interconnected by their overlapping edges so as to form at least one cavity and this cavity being filled with an active ingredient. In this configuration, the dosage form takes the form of a pouch made from two water-soluble film layers so that said film layers dissolve when the pouch is put in the mouth, and an active ingredient contained in said pouch can be released. This pouch configuration makes it possible to have a higher content of the active ingredient than comparable OTF films while avoiding thermal stress on said active ingredient during production of the dosage form.

Abstract: Compositions and methods to avoid the gag reflex to enable swallowing of pills, by applying an edible coating to the pill that generates bubbles, so that the bubbles prevent direct contact of the pill with the back of the mouth, thereby avoiding the gag reflex. Preferably the coating generates bubbles from an acid-base reaction, from compressed bubbles entrapped in hard candy, or from any other manner for creating fizzing, effervescent or popping confectionery or other food products. Optionally the coating can have a strong taste, such as by being sour, to distract away from the gag reflex. Optionally, a time release envelope is provided to delay bubbling or to block atmospheric humidity.

Abstract: Methods for buccally, sublingually, or intranasally administering a prodrug of propofol to a subject in need of treatment thereof in an amount sufficient to deliver a therapeutically effective amount of propofol to the subject are disclosed.

Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles including pharmaceutical agents that have a low water/aqueous solubility. In some embodiments, a surface coating includes a synthetic polymer having pendant hydroxyl groups on the backbone of the polymer, such as poly(vinyl alcohol) (PVA). Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: The instant invention provides pharmaceutical formulations for a long acting injectable drug product comprising a suspension of doravirine for parenteral administration via intramuscular or subcutaneous routes. The drug product can be used for the treatment or prophylaxis of infection by HIV or for the treatment, prophylaxis, or delay in the onset of AIDS (acquired immunodeficiency syndrome) or ARC (AIDS related complex).

Abstract: The present disclosure provides a cell housing device and a method of manufacturing such a device that has an array of channels to increase the ratio of surface area to volume.

Abstract: A biodegradable delivery device is disclosed that is implanted into patients to provide an extended release of one or more active pharmaceuticals for a therapeutic purpose. The delivery device comprises of: 1) an outer sheath that is composed of an inert biodegradable material that prevents the direct interactions of the core(s) with patient tissues and also facilitates the homogenous access of solvent to the surface area of the core to enable predictable core ingredient dissolution, depletion and safe and effective concentrations. 2) A Primary Core comprising one or more active ingredients plus excipients, including markers, that biodegrades and elutes all its ingredients before the sheath degrades.

Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.

Abstract: Described herein are methods and compounds for aiding in the performance of capsule endoscopy on an individual. The efficacy of the capsule endoscopy procedure is limited in at least in part by the power provided by the battery within the capsule. The methods and compounds described herein provide improved capsule endoscopies yielding valuable clinical data. In addition, the methods and compounds described herein provide for a more satisfying experience for the individual undergoing a bowel preparation related to a capsule endoscopy and thus increase compliance with the bowel preparation.

Abstract: The present invention provides an FTD and TPI-containing oral pharmaceutical composition which can be orally administered and is stable even under high humidity conditions. An oral pharmaceutical composition comprising ?,?,?-trifluorothymidine and 5-chloro-6-(2-iminopyrrolidine-1-yl) methyl-2, 4(1H, 3H)-pyrimidine dione hydrochloride as an active ingredient; and being substantially free of an additive comprising a metal salt.

Abstract: An oral dosage form of Spirulina aqueous extract is described here for delivering medications to alleviate symptoms of influenza virus. Most potent antiviral principles of spirulina being polysaccharides with molecular weight ranging from 100-300 kDa, there is need to provide permeation enhancers that help these polysaccharides in crossing the mucus membrane of oropharynx. Apart from enhancing the permeation, the formulation provides sustained effect to ameliorate symptoms of cold, cough, headache, fever related to influenza viral infection.

Abstract: The present invention relates to compositions comprising at least one film-forming agent able to adhere in a stable way to the mucosa of the mouth, esophagus and upper airways, establishing a mechanical form of protection against attack on said mucosae. Said compositions are useful in the prevention and/or treatment of disorders of the oral cavity, esophagus and upper airways caused by bacterial and/or viral agents and/or by chemical agents.

Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.

Abstract: The present application relates to a rinse-off composition comprising an oil phase and an aqueous surfactant matrix, wherein one or more active agents are dissolved in one or more non-polar, water-immiscible solvents, and the oil phase is dispersed in the aqueous surfactant matrix. The present application also relates to methods of delivering the active agent(s) to a subject in need thereof topically, for example to the skin, the hair, and scalp. The present application also relates to use of the rinse-off compositions to treat and/or prevent topical conditions such as dermatitis and psoriasis. In some embodiments, the rinse-off compositions of the present application are shampoo compositions.

Abstract: Provided herein are peptide amphiphiles (PAs). In some embodiments, provided herein are targeting PAs comprising a PA backbone and a targeting moiety. In some embodiments, provided herein are therapeutic PAs comprising a PA backbone and a therapeutic agent. In some embodiments, the peptide amphiphiles are co-assembled into nanofibers. In some embodiments, the nanofibers may be used for the treatment of atherosclerosis or related disease.

Abstract: Provided are a method of delivering target materials into extracellular vesicles including exposing the target materials and the extracellular vesicles to extracorporeal shockwaves, a method of preparing target material-introduced extracellular vesicles, extracellular vesicles prepared by the method, drug delivery vehicles including extracellular vesicles, and a method of delivering target materials into cells. The present disclosure exposes extracellular vesicles derived from natural organisms such as animal cells, plant cells, and microorganisms including bacteria and eukaryotic bacteria as well as artificially produced extracellular vesicles to extracorporeal shockwaves extracellularly. Thus, the high-level energy extracorporeal shockwaves can be used to deliver the target material into the extracellular vesicle efficiently. When treating with extracorporeal shockwaves, the ability of target material-introduced extracellular vesicles to incorporate into target cells also increases.