Patents Issued in November 17, 2020
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Patent number: 10835465Abstract: The invention relates to compositions for removing nail polish comprising a C2-C3 monoalcohol, glycerin, and propylene carbonate, wherein the glycerin and propylene carbonate are present in a glycerin to propylene carbonate ratio by weight of at least 1:3 and the concentration by weight of ethanol is at least about 16%. Methods of removing nail polish and moisturizing the hands are also provided.Type: GrantFiled: August 30, 2018Date of Patent: November 17, 2020Assignee: L'OREALInventors: Aline Aude Guimont, Chunhua Li
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Patent number: 10835466Abstract: The object is to provide a wrinkle improving agent having an excellent wrinkle improving effect. A compound expressed by the following Formula (1), or an acid addition salt thereof is used as an active ingredient of a wrinkle improving agent. (Wherein X represents an alkylene group having 1 to 2 carbon atoms in which a hydrogen atom may be substituted with a methyl group, Y represents COOR1 or CH2OR2, R1 represents a hydrogen atom, or an optionally branched alkyl group having 1 to 6 carbon atoms, and R2 represents a hydrogen atom, or an optionally branched acyl group having 1 to 6 carbon atoms.Type: GrantFiled: November 27, 2017Date of Patent: November 17, 2020Assignee: POLA CHEMICAL INDUSTRIES, INC.Inventors: Yasuhito Mori, Yuko Saitoh, Michiko Shono
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Patent number: 10835467Abstract: The present disclosure relates to a stabilization mixture, i.e. a finely distributed dispersion of hydrogenated castor oil in water with anionic, amphoteric and nonionic surfactants which is suitable for stabilizing the pearlescence of surfactant agents, particularly cosmetic agents. Furthermore, the present disclosure relates to a cold process for producing surfactant-containing agents having a pearlescent effect, in particular cosmetic cleaning agents having a pearlescent effect, and to the use of the stabilizing mixture for stabilizing surfactant agents containing pearlescent waxes and/or pearlescent pigments containing surfactant agents.Type: GrantFiled: April 26, 2016Date of Patent: November 17, 2020Assignee: Henkel AG & Co. KGaAInventors: Thomas Schroeder, Dirk Hentrich
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Patent number: 10835468Abstract: The invention relates to a cosmetic composition comprising one or more pyridinedicarboxylic acid derivatives of general formula (I) or a salt thereof and one or more antioxidants chosen from flavone heterosides, polyhydroxylated stilbenes, pyrimidinecarboxylic acid derivatives and ascorbic acid esters.Type: GrantFiled: December 21, 2015Date of Patent: November 17, 2020Assignee: L'OREALInventor: Francois Michelet
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Patent number: 10835469Abstract: A method of inhibiting copper deposition on hair and facilitating the removal of copper deposited on hair including applying to the hair a shampoo composition having histidine, rinsing the shampoo composition from the hair, applying to the hair a conditioner composition comprising histidine, and rinsing the conditioner composition from the hair.Type: GrantFiled: April 4, 2017Date of Patent: November 17, 2020Assignee: The Procter and Gamble CompanyInventors: Jennifer Mary Marsh, Casey Patrick Kelly
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Patent number: 10835470Abstract: The present invention relates to a cosmetic composition comprising a compound represented by Formula 1 below as an active ingredient. in the above Formula 1, R1 is -glc(2-1)glc, R2 is -glc, or R1 is -glc, R2 is -glc(6-1)ara(pyr).Type: GrantFiled: October 26, 2016Date of Patent: November 17, 2020Assignee: AMOREPACIFIC CORPORATIONInventors: Gi Baeg Nam, Dong Hyun Kim, Yong Deog Hong, Cheng Yi Zhang, Jun Seong Park
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Patent number: 10835471Abstract: The subject of the present disclosure is a method for coloring of human hair, comprising the following steps in the specified sequence A) Mixing a first component (K1) with a second component (K2) to produce a first mixture (M1), B) Mixing the mixture (M1) with a third component (K3) to produce a second mixture (M2), C) Application of the mixture (M2) on the hair, D) Allowing the mixture (M2) to take effect for a period of from about 30 seconds to about 45 minutes, E) Rinsing the mixture (M2) from the hair, wherein the first component (K1) is a dye preparation comprising at least one oxidation dye precursor, and the second component (K2) is a color diluent which does not contain any oxidation dye precursors or oxidants and the third component (K3) is an oxidant preparation comprising at least one oxidant.Type: GrantFiled: December 15, 2016Date of Patent: November 17, 2020Assignee: Henkel AG & Co. KGaAInventors: Camille Grosjacques, Aileen Wagner, Susanne Hagenow, Hartmut Manneck, Astrid Kleen-Fehres
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Patent number: 10835472Abstract: The present disclosure relates to cosmetic compositions for cleaning keratin fibres. An exemplary cosmetic composition includes, in relation to the total weight of the cosmetic composition, a) a particle comprising, in relation to the total weight of the particle, from about 65 to about 99% by weight of a native and/or physically modified starch, b) an anionic polymer comprising a structural unit of formula (I), a structural unit of formula (II), and a structural unit of formula (III): in which R1, R2 and R4, independently of one another, stand for a hydrogen atom or a C1-C4 alkyl group, R3 stands for a branched or unbranched, saturated or unsaturated C1-C12 alkyl group, R5 stands for a branched or unbranched, saturated or unsaturated C6-C14 alkyl group, and A stands for oxygen, sulfur or an NH group, and c) at least one propellant.Type: GrantFiled: August 30, 2018Date of Patent: November 17, 2020Assignee: Henkel AG & Co. KGaAInventors: Thorsten Knappe, Tim Bethge
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Patent number: 10835473Abstract: The present disclosure relates to cosmetic compositions for the cleaning of keratinic fibers. An exemplary cosmetic composition includes, based on the total weight of the cosmetic composition, a) a particulate comprising, based on the total weight of the particulate, a1) from about 65 to about 98% by weight of a starch, and a2) from about 1.0 to about 3.0% by weight of a pigment, b) an anionic polymer comprising structural units of the formula (I), the formula (II), and the formula (III): wherein R1, R2 and R4, each independently of one another, stand for a hydrogen atom or a C1-C4 alkyl group, R3 stands for a branched or unbranched, saturated or unsaturated C1-C12 alkyl group, R5 stands for a branched or unbranched, saturated or unsaturated C6-C14 alkyl group, A stands for oxygen, sulfur or an NH group, and c) a foaming agent.Type: GrantFiled: August 30, 2018Date of Patent: November 17, 2020Assignee: Henkel AG & Co. KGaAInventors: Thorsten Knappe, Tim Bethge
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Patent number: 10835474Abstract: The present disclosure relates to a cosmetic preparation for the temporary shaping of hair, which comprises a combination of two specific copolymers. The cosmetic composition provides an extremely good hold.Type: GrantFiled: December 15, 2017Date of Patent: November 17, 2020Assignee: Henkel AG & Co. KGaAInventors: Julia Bibiane Lange, Rene Scheffler, Diane Metten, Cyrielle Martinez
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Patent number: 10835475Abstract: The invention relates to the field of the production of aqueous compositions comprising rheology-modifying agents, in particular the production of aqueous cosmetic or detergent compositions having improved thickening and clarity properties and also good suspending properties. In particular, the invention relates to a rheology-modifying agent which is a copolymer obtained by polymerization of at least one cross-linking monomer with at least one anionic monomer comprising at least one polymerizable ethylenic unsaturation and at least one hydrophobic nonionic monomer comprising at least one polymerizable ethylenic unsaturation.Type: GrantFiled: June 2, 2017Date of Patent: November 17, 2020Assignee: COATEXInventors: Clementine Champagne, Jean-Marc Suau
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Patent number: 10835476Abstract: A mascara composition including a film-forming polymer portion and a particulate portion is provided. The film-forming polymer portion comprises a high molecular weight vinylpyrrolidone homopolymer and the particulate portion comprises an inorganic particulate. The mascara composition comprises at least about ten percent by weight of the vinylpyrrolidone homopolymer and is substantially free of wax. Methods of applying makeup to the eyelashes are also provided.Type: GrantFiled: November 29, 2017Date of Patent: November 17, 2020Assignee: L'OREALInventors: Christopher Pang, Jody Ebanks, Chunhua Li
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Patent number: 10835477Abstract: Oral care compositions having polyethylene glycol are more phase stable, particularly with certain flavorants that have a specified range of Dielectric Constant and/or water number and/or C log P value.Type: GrantFiled: April 14, 2015Date of Patent: November 17, 2020Assignee: The Procter & Gamble CompanyInventors: Swapna Basa, Ross Strand, Haiqiu Tang, Hongmei Yang
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Patent number: 10835478Abstract: The present disclosure relates a method for the lightening of keratinous fibers, particularly human hair, wherein a lightening agent (AM) containing at least one special dimethylcyclosiloxane and at least one special polydimethylsiloxane is used. Use of the special siloxanes results in improved care of the keratinous fibers with simultaneous improvement of the lightening effect. Furthermore, the present disclosure relates to a corresponding packaging unit (kit-of-parts) and the use of a combination of special siloxanes to improve the care of keratinous fibers while simultaneously improving the lightening effect.Type: GrantFiled: June 3, 2016Date of Patent: November 17, 2020Assignee: Henkel AG & Co. KGaAInventors: Sylvia Kerl, Camille Grosjacques, Katharina Krause
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Patent number: 10835479Abstract: The invention relates to systems and methods for improving the appearance of the skin. The systems comprise 1) a skin-tightening composition comprising at least one thermoplastic elastomer and at least one adhesive polymer; and 2) a long-wear cosmetic composition comprising at least one silicone-polyamide copolymer, at least one silicone film former, and at least one volatile oil. Methods comprise applying the compositions of the systems on to the skin sequentially after a drying period.Type: GrantFiled: December 30, 2016Date of Patent: November 17, 2020Assignee: L'OREALInventors: Anne-Laure Suzanne Bernard, Alexandra Jane Elisa Farran, Yang Deng
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Patent number: 10835480Abstract: A method of treating the hair including providing a concentrated hair care composition in a foam dispenser. The concentrated hair care composition includes one or more silicones, perfume, and less than 6% high melting point fatty compounds. The method also includes dispensing the concentrated hair care composition from the foam dispenser as a dosage of foam; applying the foam to the hair; and rinsing the foam from the hair. The foam has a density of from about 0.025 g/cm3 to about 0.40 g/cm3 when dispensed from the foam dispenser. The one or more silicones form a silicone layer that has a Targeted Deposition Index of from about 0.8 to about 1.6.Type: GrantFiled: April 20, 2017Date of Patent: November 17, 2020Assignee: The Procter and Gamble CompanyInventors: Robert Wayne Glenn, Jr., Kathleen Mary Kaufman, Kevin Lee Doyle, Dariush Hosseinpour, Jean Jianqun Zhao
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Patent number: 10835481Abstract: Polymers comprising at least one cationic functional group and at least one ultraviolet light-absorbing compound are disclosed herein. The resulting polymers exhibit ultraviolet light-absorbing properties and may be used in sunscreen compositions for skin and/or hair.Type: GrantFiled: March 16, 2018Date of Patent: November 17, 2020Assignee: COAST SOUTHWEST, INC.Inventor: Amit Patel
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Patent number: 10835482Abstract: A composition (d) includes (per 100% of its weight): a) 90 wt.-% to 99.0 wt.-% water including, in dissolved form, 0.002 mol/L to 0.1 mol/L of at least one salt of ammonium cation or of a monovalent or multivalent metal cation with an organic or inorganic anion; b) 0.5 wt.-% to 5 wt.-% of at least one crosslinked anionic polyelectrolyte; and c) 0.5 wt.-% to 5 wt.-% of at least one compound having formula (II), where the weight ratio of the crosslinked anionic polyelectrolyte to the compound of formula (II) is greater than or equal to 0.2 and less than or equal to 2.0, and the molar ratio of the compound of formula (II) to the salt is greater than or equal to 0.05 and less than or equal to 1. Also disclosed is the composition in cosmetics and to a method for lightening the thickened salt-rich composition.Type: GrantFiled: July 18, 2017Date of Patent: November 17, 2020Assignee: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPICInventors: Benoit Verdu, Cindy Sourdon, Alicia Roso
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Patent number: 10835483Abstract: An antiperspirant stick composition can include a synthetic wax having a melting point of less than or equal to 90° C., a melting point additive present at a weight ratio to the synthetic wax to provide the composition with a melting point greater than or equal to 40° C., an effective amount of an antiperspirant active agent, and less than 2 wt % hydrogenated oils, petrolatum, 12-hydroxystearic acid, polyethylenes having a melting point greater than or equal to 60° C., and combinations thereof.Type: GrantFiled: October 10, 2017Date of Patent: November 17, 2020Inventors: Tyler Mikkelsen, Sofia Carolina Herrera, Nancy Rodgers
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Patent number: 10835484Abstract: An oral care composition and methods for whitening teeth are disclosed herein. The whitening composition may include an orally acceptable vehicle and one or more abrasives. The one or more abrasives may include at least one plant-based abrasive. The method for whitening teeth may include contacting the oral care composition with surfaces of the teeth at least twice a day for at least nine days.Type: GrantFiled: December 26, 2018Date of Patent: November 17, 2020Assignee: Colgate-Palmolive CompanyInventors: Saide Tang, Lin Fei, Suman Chopra, Abhishek Agrawal
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Patent number: 10835485Abstract: The present invention is concerned with microorganisms or fragments thereof as sensorically neutral oral care agents, particularly for prevention of dental calculus, as anti-caries agents and/or anti-oral malodor agents. The invention is furthermore concerned with compositions comprising microorganisms or fragments thereof for reducing mutans Streptococci. Such compositions can be used in oral care compositions, e.g. for caries prophylaxis, or for prophylaxis of dental calculus or oral malodor. They may also or instead be used for prevention or treatment of oral malodor. As the microorganisms and fragments thereof according to the present invention have a very low, unobtrusive smell and taste, they are particularly suited as sensorically neutral agents for preventment of dental calculus, caries, oral biofilm formation and/or for prevention or treatment of oral malodor.Type: GrantFiled: December 6, 2016Date of Patent: November 17, 2020Assignee: BASF SEInventor: Markus Pompejus
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Patent number: 10835486Abstract: Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.Type: GrantFiled: December 15, 2016Date of Patent: November 17, 2020Assignees: Massachusetts Institute of Technology, The Children's Medical Center CorporationInventors: Minglin Ma, Daniel G. Anderson, Robert S. Langer, Omid Veiseh, Arturo Jose Vegas, Joshua Charles Doloff, Delai Chen, Christian J. Kastrup
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Patent number: 10835487Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.Type: GrantFiled: March 30, 2020Date of Patent: November 17, 2020Assignee: TherapeuticsMD, Inc.Inventors: Brian A. Bernick, Julia M. Amadio, Peter H. R. Persicaner
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Patent number: 10835488Abstract: Described herein are stable orally disintegrating tablets containing a proton pump inhibitor, methods for making the same, and methods for treating subjects in need thereof. In particular, the orally disintegrating tablets are composed of a plurality of coated units admixed with a disintegrant that demonstrate decreased friability and increased hardness.Type: GrantFiled: September 13, 2018Date of Patent: November 17, 2020Assignee: DEXCEL PHARMA TECHNOLOGIES LTD.Inventors: Victor Pevzner, Sheera Moses-Heller
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Patent number: 10835489Abstract: The present application discloses modified release mucoadhesive formulations of mycophenolate mofetil and pharmaceutical compositions thereof useful in the treatment of, for example, post-transplant organ rejection. Method of preparing the formulations is also disclosed.Type: GrantFiled: March 4, 2019Date of Patent: November 17, 2020Assignee: University of SaskatchewanInventors: Ellen K. Wasan, Ahmed Shoker, Holly G. Mansell, Kishor M. Wasan
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Patent number: 10835490Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.Type: GrantFiled: February 25, 2019Date of Patent: November 17, 2020Assignee: Infirst Healthcare LimitedInventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
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Patent number: 10835491Abstract: Provided herein are methods and processes for emulsifying non-polar compounds, such as omega fatty acids. Also provided are compositions that can be prepared according to the methods and processes described herein. The compositions, for example, have a high amount of the non-polar compound, such as a large amount of omega fatty acids. The non-polar compounds are also present in very small droplets within composition. For example, the mean or median particle size of the droplets is less than about 5 ?m. Further, the composition includes a low amount of surfactant, such as less than about 10-15% of the surfactant.Type: GrantFiled: October 3, 2018Date of Patent: November 17, 2020Assignee: BARLEAN'S ORGANIC OILS, LLCInventor: Peter Nguyen
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Patent number: 10835492Abstract: Lyophilized liposomal formulations with two or more encapsulated drugs are disclosed. These formulations display superior drug retention profiles and also maintain size distribution following lyophilization and reconstitution.Type: GrantFiled: November 5, 2018Date of Patent: November 17, 2020Assignee: CELATOR PHARMACEUTICALS, INC.Inventors: Donna Cabral-Lilly, Lawrence Mayer, Paul Tardi, David Watkins, Yi Zeng
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Patent number: 10835493Abstract: Proteo-microparticles such as proteoliposomes comprising a microparticle (e.g., a liposome) and platelet membrane proteins, wherein the proteo-microparticles are capable of binding to monocytes, neutrophils, or other circulating blood cells capable of migrating to an injured site. Also provided herein are uses of the proteoliposomes for delivering a therapeutic agent via monocytes to an injured site.Type: GrantFiled: April 20, 2016Date of Patent: November 17, 2020Assignee: ACADEMIA SINICAInventors: Patrick C. H. Hsieh, Bill Cheng
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Patent number: 10835494Abstract: The invention refers to a product made of liposomes which comprises lactoferrin and a component selected from hyaluronic acid or chitosan, as active ingredients, as well as to compositions comprising it and their use in the prevention and/or treatment of diseases related to the eye, such as for example the ocular diseases characterized by the presence of an inflammatory condition.Type: GrantFiled: July 31, 2019Date of Patent: November 17, 2020Assignee: TDC Technology Dedicated to Care srlInventors: Ana Laura López Machado, Elena Sánchez López, Maria Luisa Garcia Lopez, Martina Biancardi
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Patent number: 10835495Abstract: Compositions containing a biologically active material and a non-ordered inorganic oxide material are disclosed. Methods of making and using compositions containing a biologically active material and a non-ordered inorganic oxide material are also disclosed.Type: GrantFiled: November 13, 2013Date of Patent: November 17, 2020Assignees: W. R. Grace & Co.-Conn., Formac Pharmaceuticals N.V.Inventors: Cristian Libanati, Michiel Van Speybroeck, Frederik Hendrik Monsuur
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Patent number: 10835496Abstract: Lonafarnib and ritonavir, or a pharmaceutically acceptable salt thereof, are used in combination to treat HDV infection. In one aspect, amorphous co-precipitates comprising lonafarnib, ritonavir, and a co-polymer are provided.Type: GrantFiled: April 21, 2016Date of Patent: November 17, 2020Inventors: Patrick Gosselin, Aimesther Betancourt
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Patent number: 10835497Abstract: The present invention relates to a rivastigmine-containing sustained-release pharmaceutical composition and, more specifically, to a rivastigmine-containing sustained-release pharmaceutical composition, which is a sustained-release preparation containing a pH-dependent delayed release phase, wherein, by controlling the release of the pharmaceutical composition to be minimized in the stomach at the initial stage of administration, the pharmaceutical composition can lower the maximum blood concentration (Cmax) compared with existing products while arriving at an effective blood concentration, thereby reducing side effects, and thereafter, maintaining the effective blood concentration through the sustained-release of main ingredients.Type: GrantFiled: April 27, 2016Date of Patent: November 17, 2020Assignee: NAVIPHARM CO., LTD.Inventors: Sang Geun Park, Hye Gyeong Shin, Jeong Woo Bae, Hyun Ju Choi
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Patent number: 10835499Abstract: Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.Type: GrantFiled: December 30, 2016Date of Patent: November 17, 2020Assignee: Corium, Inc.Inventors: Eun Soo Lee, Amit K. Jain, Parminder Singh
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Patent number: 10835500Abstract: A medicament for accelerated wound healing is proposed containing derivatives of the formula (I), in which R1 stands for hydrogen or methyl.Type: GrantFiled: June 16, 2015Date of Patent: November 17, 2020Assignee: Symrise AGInventors: Daniela Busse, Heike Conrad, Hanns Hatt
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Patent number: 10835501Abstract: The invention relates to pharmaceutical compositions comprising a statin and a cannabinoid, and their use for the treatment of hypercholesterolemia and atherosclerosis. It has been found that compositions combining a statin and a cannabinoid are improved over existing statin formulations. The compositions of the invention for example allow for a lower effective dose of statin and a reduction of the adverse effects seen with statins taken alone. Dosing ranges and formulations suitable for oral, buccal, and sublingual administration are disclosed. Various specific cannabinoids such as cannabidiol and synthetic cannabidiols selected for their anti-inflammatory, antioxidant, and anti-atherosclerotic effect are shown to be particularly advantageous.Type: GrantFiled: October 1, 2017Date of Patent: November 17, 2020Assignee: Indication BioScience LLCInventors: James Smeeding, Mathew Sherwood
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Patent number: 10835502Abstract: This disclosure relates to a method of reducing a fat deposit comprising injecting an alcohol-containing pharmaceutical composition into the fat deposit. The method may be effective in improving the appearance of or reducing the weight or volume of the fat deposit.Type: GrantFiled: October 15, 2019Date of Patent: November 17, 2020Assignee: Polithera, Inc.Inventors: Adam M. Rotunda, Vince Afsahi
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Patent number: 10835503Abstract: The invention relates to a pre-filled syringe, an auto-injector device comprising such pre-filled syringe, a method of administering a pharmaceutical composition with such auto-injector device, and a manufacturing method for such auto-injector device. The pre-filled syringe comprises a container and a needle. The container is filled with a pharmaceutical composition comprising epinephrine, a buffer, and water. The buffer is configured to buffer in a pH range between 3 and 4. The needle is adhered to the container by means of a urethane acrylate or urethane methacrylate acrylic light cure adhesive, which is configured to provide a pull out resistance of the needle relative to the container which is between 30 N to 100 N, preferably between 50 N to 70 N, more preferably greater than 60 N after 90 days exposure to the pharmaceutical composition at 40° C. and 75% relative humidity (RH). In an example, the pharmaceutical composition is for the treatment of an anaphylactic event.Type: GrantFiled: January 13, 2017Date of Patent: November 17, 2020Assignee: TEVA PHARMACEUTICALS USA, INC.Inventors: Vijay Joguparthi, Rosario LoBrutto
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Patent number: 10835504Abstract: The present disclosure relates to topical compositions comprising one or more topical anesthetics or analgesics; a vitamin B3 compound; and a coating agent. In some embodiments, the composition comprises about 1% to about 10% w/w of the composition of the topical anesthetic, topical analgesic, or a combination thereof; about 1% to about 10% w/w of the composition of the vitamin B3 compound; and about 5% to about 50% w/w of the composition of the coating agent. In some embodiments, the composition further includes a pharmaceutically acceptable base. In some embodiments, the pharmaceutically acceptable base comprises about 35% to about 85% w/w of the composition of a pharmaceutically acceptable oil; about 1% to about 20% w/w of the composition of a pharmaceutically acceptable wax; or a combination thereof. Such compositions are useful for treating anal itch or pruritus ani.Type: GrantFiled: April 18, 2019Date of Patent: November 17, 2020Assignee: G&S Laboratories, Inc.Inventors: Robert A. Ganz, Mo E. Saremi, William Christopfel
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Patent number: 10835505Abstract: There is disclosed an oral pharmaceutical formulation of bitter compounds that are agonists of taste receptor type 2 (TAS2R) receptors for the function of appetite suppression for the treatment of obesity. More specifically, the present disclosure provides an anti-obesity oral formulation comprising a bitter agent selected from the group consisting of denatonium salts including benzoate (DB), chloride (DC), acetate (DA), citrate (DCl), saccharide (DS), tartarate (DT), maleate (DM), 3-caffeoylquinic-1,5-lactone (3-CQL), chlorogenic acids (CGA), combinations thereof, and pharmaceutical excipients to facilitate a sustained release during transit through the gastrointestinal (GI) tract. Preferably, the oral pharmaceutical formulation further comprises either or both a sweet antagonist selected from the group consisting of lactisole, gymnemic acid, ziziphin, hodulcine, and combinations thereof, and a sour organic acid.Type: GrantFiled: June 11, 2018Date of Patent: November 17, 2020Assignee: Aardvark Therapeutics, Inc.Inventor: Tien-Li Lee
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Patent number: 10835506Abstract: Disclosed herein are methods of treating and preventing muscle loss using ornithine in combination with at least one of phenyl acetate and phenylbutyrate.Type: GrantFiled: August 16, 2016Date of Patent: November 17, 2020Assignee: Ocera Therapeutics, Inc.Inventors: Christopher F. Rose, Franck Rousseau
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Patent number: 10835507Abstract: The present specification provides methods of treating a muscular disorder with a combination of a RXR agonist and a thyroid hormone.Type: GrantFiled: October 31, 2016Date of Patent: November 17, 2020Assignee: Io Therapeutics, Inc.Inventors: Roshantha A. Chandraratna, Martin E. Sanders
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Patent number: 10835508Abstract: One embodiment described herein is related to methods and compositions, such as nutraceutical formulations and dietary supplements, comprising C16:1n7-palmitoleate or derivatives thereof. The methods and compositions comprising C16:1n7-palmitoleate, or derivatives thereof, safely and effectively prevent or mitigate manifestations of cardiovascular disease, including coronary artery disease and the accumulation of cholesterol or lipid deposits in the blood vessels of a subject.Type: GrantFiled: May 8, 2019Date of Patent: November 17, 2020Assignee: TERSUS LIFE SCIENCES, LLCInventor: Jeffrey Green
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Patent number: 10835509Abstract: A method for the prevention and/or treatment of dementia in a human subject; the method comprising the step of administering an effective amount of a composition comprising at least one carotenoid selected from the group consisting of lutein, zeaxanthin and meso-zeaxanthin; and a composition comprising at least one omega-3 fatty acid.Type: GrantFiled: May 15, 2018Date of Patent: November 17, 2020Assignee: HOWARD FOUNDATION HOLDINGS LTD.Inventors: Alan Norman Howard, John Nolan, Riona Mulcahy
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Patent number: 10835510Abstract: Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating acute wounds, chronic wounds and/or a wound or epithelial tissue surface that contains bacterial biofilm, including unexpected synergy between bismuth-thiol (BT) compounds and certain antibiotics, to provide topical formulations including antiseptic formulations, for management and promotion of wound healing and in particular infected wounds. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating gram-negative bacterial infections.Type: GrantFiled: July 31, 2018Date of Patent: November 17, 2020Assignee: MICROBION CORPORATIONInventors: Brett Hugh James Baker, Philip Domenico
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Patent number: 10835511Abstract: A pharmaceutical composition comprises a taxane (e.g., paclitaxel, docetaxel, cabazitaxel, larotaxel, ortataxel, and/or tesetaxel) in a mixture of first and second surfactants. The absorption of the taxane is increased from the pharmaceutical composition is greater than the sum of the absorption of docetaxel from either the first or the second surfactant. The increase in absorption is especially enhanced when the ratio of the first surfactant to the second surfactant in the pharmaceutical composition is between 60:40 and 85:15 by weight, and the total surfactant weight does not exceed 98% of the total weight. Polysorbate 80, polysorbate 20, and caprylocaproyl polyoxylglycerides serve as suitable first surfactants, and polysorbate 80 or polyethyoxylated castor oil serve as suitable second surfactants. The stability of the pharmaceutical composition may be enhanced by further including a stabilizer (e.g., citric acid and/or ascorbic acid).Type: GrantFiled: September 27, 2016Date of Patent: November 17, 2020Assignee: Athenex HK Innovative LimitedInventors: Denise S. B. Chan, Ming Tsung Lee, Weng Li Yoon, Johnson Yiu-Nam Lau
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Patent number: 10835512Abstract: Compositions and methods for the treatment of respiratory syncytial virus infections are provided.Type: GrantFiled: July 10, 2019Date of Patent: November 17, 2020Assignee: Respivant Sciences GmbHInventors: Pravin Soni, William Gerhart, Manfred Keller, Ahmet Tutuncu
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Patent number: 10835513Abstract: Disclosed herein are methods and compositions for treating learning and memory deficits associated with Noonan Syndrome.Type: GrantFiled: June 27, 2014Date of Patent: November 17, 2020Assignee: The Regents of the University of CaliforniaInventors: Alcino Silva, Yong-Seok Lee, Dan Ehninger
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Patent number: 10835514Abstract: Pharmaceutical compositions of muscarinic acetylcholine receptor antagonists suitable for administration via a dry powdered inhaler and methods of using the compositions for treating respiratory disease are provided.Type: GrantFiled: January 7, 2017Date of Patent: November 17, 2020Assignee: THERON PHARMACEUTICALS, INC.Inventors: Meenakshi S. Venkatraman, Xiaoming Zhang, Phillip Haywood
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Patent number: 10835515Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.Type: GrantFiled: July 1, 2019Date of Patent: November 17, 2020Assignee: ORION CORPORATIONInventors: Olli Törmäkangas, Terhi Heikkinen