Patents Issued in November 17, 2020
  • Patent number: 10835616
    Abstract: The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion —(CH2CH2O)n—, in which n is a number of six or more; and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: November 17, 2020
    Assignee: POLYTHERICS LIMITED
    Inventors: Antony Godwin, George Badescu, Matthew Bird, Penny Bryant, David Morris, Mark Frigerio
  • Patent number: 10835617
    Abstract: A method of producing synergistic and enhanced efficacy in treating a disease in a subject includes providing an antibody, the antibody being a classic antibody or a modified biologic molecule that blocks a first target in the subject; providing a drug, the drug being a small molecule agent that blocks the first target or a second target in the subject; connecting the antibody and the drug with a linker to form an Antibody-Drug Synergism (ADS) compound; and treating the disease with the ADS compound. The linker is hydrolyzed in the subject over a certain time so that both the antibody and the drug exert their functions simultaneously, and the ADS compound confers better efficacy than either the antibody or the drug alone due to a synergism of the ADS compound.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: November 17, 2020
    Assignee: ADS THERAPEUTICS LLC
    Inventors: Jinsong Ni, Rong Yang
  • Patent number: 10835618
    Abstract: The present invention relates to an isolated specific binding member capable of binding sialyl-di-Lewisa, and associated treatments and pharmaceutical compositions for treatment of cancer.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: November 17, 2020
    Inventors: Lindy Gillian Durrant, Mireille Vankemmelbeke, Silvana Tivadar, Tina Parsons, Richard McIntosh
  • Patent number: 10835619
    Abstract: Provided herein is a tumor associated macrophage (TAM)-targeting liposome. The liposome has a lipid bilayer, a targeting agent associated with the lipid bilayer, and a repolarizing agent associated with the lipid bilayer. The targeting agent optionally comprises an antibody or fragment thereof that selectively binds a TAM, whereas the repolarizing agent repolarizes the TAM upon binding of the TAM by the targeting agent. Also provided is a pharmaceutical composition comprising the TAM-targeting liposomes and a method of treating a subject with cancer with the compositions or liposomes described herein.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: November 17, 2020
    Assignee: Verily Life Sciences LLC
    Inventors: Stephen Morton, Graziella Solinas
  • Patent number: 10835620
    Abstract: This invention is generally related to novel compositions for treating or preventing heart failure. Specifically, the disclosure provides a composition comprising an amino-terminal domain of Beta.adrenergic receptor kinase-1 (Beta.ARKnt) peptide, or a nucleic acid encoding Beta.ARKnt. Further disclosed are methods of using the compositions for treating or preventing heart failure in a subject or for altering Beta.-adrenergic receptor (Beta.AR) density in a subject.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: November 17, 2020
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Walter J. Koch, Sarah M. Schumacher-Bass
  • Patent number: 10835621
    Abstract: The present invention relates to a bicistronic expression vector for silencing a gene specifically in astrocytes and neurons, comprising two expression cassettes comprising a first and a second silencer sequence, respectively, wherein the expression of said first silencer sequence within astrocytes is regulated by an astrocyte-specific promoter and the expression of said second silencer sequence within neurons is regulated by a neuron-specific promoter. In a preferred embodiment, said first and second silencer sequences are SOD1 silencer sequences. Pharmaceutical composition comprising said bicistronic vector and the use of the same in the treatment of motoneuron diseases are further described.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: November 17, 2020
    Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)
    Inventors: Julianne Aebischer, Bernard Schneider, Cylia Rochat
  • Patent number: 10835622
    Abstract: The invention is a simplified model on kidney rejection in animals and its setting approach. The method involves isolating dendritic cells from male mice and isolating T cells from female mice and then using the naive T cells in vitro to culture concurrently with male dendritic cells. Those activated T cells from female origin were injected into renal cortex in male mice for the purpose of attacking renal cortex. The animal model simulates the renal transplant rejection method to enable effective induction of renal transplant immune reaction.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: November 17, 2020
    Assignees: NATIONAL YANG-MING UNIVERSITY, TAIPEI VETERANS GENERAL HOSPITAL, TAICHUNG VETERANS GENERAL HOSPITAL
    Inventors: Der-Cheng Tarng, Nien-Jung Chen, Shuo-chun Weng
  • Patent number: 10835623
    Abstract: Provided herein are examples of metal chelating ligands that have high affinity for manganese. The resultant metal complexes can be used as MRI contrast agents, and can be functionalized with moieties that bind to or cause relaxivity change in the presence of biochemical targets.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: November 17, 2020
    Assignee: The General Hospital Corporation
    Inventors: Eric M. Gale, Peter Caravan
  • Patent number: 10835624
    Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: November 17, 2020
    Assignees: AC IMMUNE S.A., LIFE MOLECULAR IMAGING SA
    Inventors: Heiko Kroth, Jérôme Molette, Vincent Darmency, Hanno Schieferstein, Andre Müller, Heribert Schmitt-Willich, Mathias Berndt, Felix Oden, Emanuele Gabellieri
  • Patent number: 10835625
    Abstract: The present invention provides radiolabeled trimethoprim which are useful in imaging tests such as PET scans. The compounds show robust bacterial uptake in vitro and identify infections from inflammation or tumor when administered to a subject. The compounds show rapid and sensitive detection of Ec DHFR containing tumors from control tumors and background tissue. In one aspect, a compound having the structure of formula (I) is provided or a pharmaceutically acceptable salt or prodrug thereof, wherein R is defined herein. Also provided are compositions containing these compounds, positron emission tomography reporter probe comprising these compounds, and methods of imaging a bacterial infection, tracking or monitoring bacteria, distinguishing a bacterial infection from inflammation or tumor, monitoring genetically fused protein expression, and monitoring genetically engineered cells in clinical scenarios such as immunotherapy for cancer treatment.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: November 17, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark Sellmyer, Robert H. Mach, David A. Mankoff, Iljung Lee
  • Patent number: 10835626
    Abstract: Systems and methods for combined HINS and non-HINS lighting for surface disinfection. A lighting system controller is provided, which includes a memory, an i/o interface, and an electronic processor. The processor is configured to retrieve from the memory at least one characteristic of an area to be disinfected; determine, based on a signal received from a first sensor positioned to sense the presence of a person in the area, whether a person is present in the area; and, when a person is present in the area, determine a first drive signal based on the at least one characteristic and the presence of the person, and a second drive signal based on the presence of the person in the area and the first drive signal. The processor provides the first drive signal to drive to a HINS LED array and the second drive signal to drive a non-HINS LED array.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: November 17, 2020
    Assignee: Hubbell Incorporated
    Inventors: Pritam Yadav, Thomas James Veltri
  • Patent number: 10835627
    Abstract: A light emitting device which inactivates microorganisms is disclosed. The light emitting device may include a flexible light emitting layer emitting a light; and a transparent or translucent layer over the flexible light emitting layer. The light may travel through and exit an exterior surface of the transparent or translucent layer, creating an exiting light. The exiting light exiting the transparent or translucent layer may have at least a portion thereof having a wavelength in a range of 380 to 420 nanometers, and may disinfect the exterior surface of the transparent or translucent layer. The light emitting device may be used alone to create a self-disinfecting high touch surface, e.g., on a door, or may be shaped to mate with other structure to create a disinfecting high touch surface.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: November 17, 2020
    Assignee: Vital Vio, Inc.
    Inventors: Nicholas Jones, Colleen Costello, Cori Winslow, Robert Barron, William Grambo, Jorel Lalicki
  • Patent number: 10835628
    Abstract: A germicidal system for use in disinfecting a human interface device includes at least one human interface device. One or more ultra-violet (UV) light sources are used in proximity to the at least one human interface device for disinfecting a touch surface of the human interface device below a surgical grade sterilization. A memory for storing usage data of the at least one UV light source. At least one server is used for providing a central storage location for usage data supplied from the memory and a computer is used in communication with the at least one server for controlling the operational parameters of the at least one UV light source.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: November 17, 2020
    Assignee: UV Partners, Inc.
    Inventor: Theodore John Cole
  • Patent number: 10835629
    Abstract: A device for generating singlet oxygen is provided. The device has elongated posts extending from a surface, the lateral sides of which have particles with a sensitizer that converts triplet oxygen to single oxygen upon exposure to light. An optical fiber conveys light to the sensitizer and a gas supply tube conveys oxygen to the sensitizer. The device is configured to keep the sensitizer from contacting external fluids, such as saliva.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: November 17, 2020
    Assignee: Research Foundation of the City University of New York
    Inventors: Alan M. Lyons, Alexander Greer, QianFeng Xu
  • Patent number: 10835630
    Abstract: An air freshener for vehicles including a main body for holding a container for volatile substances and a foldable clip which can be placed in a substantially perpendicular position with respect to the main body. The foldable clip is rotatable with respect to the main body. The clip is always connected with the main body, so that it is sold with it occupying a reduced space in the package. The clip can be rotated to be adapted to any kind of ventilation grids.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: November 17, 2020
    Assignee: ZOBELE HOLDING S.P.A.
    Inventors: Stefano Deflorian, Walter Sordo
  • Patent number: 10835631
    Abstract: A photocatalytic element including: a photocatalytic layer containing at least one photocatalytic material; and a light emitting source in optical communication with the photocatalytic material, the light emitting source disposed sufficiently proximal to the photocatalytic material to raise the surface temperature of at least some of the photocatalytic material to a temperature between 10° C. and 90° C. is provided.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: November 17, 2020
    Assignee: Nitto Denko Corporation
    Inventors: Ekambaram Sambandan, Sazzadur Rahman Khan, Takuya Fukumura, Hiroyuki Katayama
  • Patent number: 10835632
    Abstract: An autoclave with an upper hatch and a bottom hatch is terminated with elliptical end caps has an agitator placed inside it. The autoclave is inclined in relation to the ground plane. An external jacket is mounted on the cylindrical section of the internal pressure chamber. The jacket is divided into pressure-separated parts Inside the internal pressure chamber a paddle agitator shaft is mounted. The agitator mounting arrangement is out-of-alignment in relation to the axis of symmetry of the autoclave cylindrical section The size of the shift does not exceed ? of the radial length of the cross-section of the cylindrical section of the internal pressure chamber. The agitator's paddles has two shields shifted in the agitator's axis of symmetry in relation to its paddle by a phase angle equal to 90°. The shield height does not exceed ? of the height of the agitator's paddle.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: November 17, 2020
    Assignee: BIOELEKTRA GROUP S.A.
    Inventor: Eryk Jaroslaw Brajtling
  • Patent number: 10835633
    Abstract: The present invention relates to novel and secure tampons that overcome the problems associated with conventional non-secure tampons, and methods of using the novel and secure tampons.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: November 17, 2020
    Assignee: THINK DO IT
    Inventor: Suzanne Raina Natbony
  • Patent number: 10835634
    Abstract: A process for agglomerating superabsorbent particles, wherein polymer particles having a particle size of 250 ?m or less are dispersed in a hydrophobic organic solvent, the dispersed polymer particles are mixed with an aqueous monomer solution, the total amount of water applied to the dispersed polymer particles being at least 100% by weight, based on the dispersed polymer particles, and the monomer solution is polymerized.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: November 17, 2020
    Assignee: BASF SE
    Inventors: Tina Mark, Thomas Daniel, Erich Lutz, Stefan Molter
  • Patent number: 10835635
    Abstract: A tissue adhesive with healing promotion properties formed from a mixture of natural polymers and an activating agent that enhances the adhesive properties of the natural polymer mixture is described. Use of an activating agent and a combination of the natural polymers is unique. The natural polymer tissue adhesive may be useful as a post-operative application for tonsillectomy or adenoidectomy surgery, as an internal tissue adhesive for surgery or wound repair or for application to a burn or skin donor site. For internal use, an optional treatment to improve resistance of the activated adhesive to body fluids is also described. The adhesive described not only functions as an adhesive but would also serve as a protective barrier when applied to surgery or skin sites. In addition, the natural polymers would promote healing due to the inherent properties of the polymers selected.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: November 17, 2020
    Assignee: HCS Innovation, LLC
    Inventors: Ronnie Michael Hanes, Adele Lamping Hanes
  • Patent number: 10835636
    Abstract: A dressing composition for use as a skin dressing comprises an elastomeric-adhesive composition, and a zeolite comprising releasably adsorbed nitric oxide. The zeolite may comprise a transition metal cation such as Co, Fe, Mn, Ni, Cu, Zn, Ag or a mixture thereof as an extra-framework metal cation, preferably Zn. The elastomeric adhesive composition may be a hydrocolloid-adhesive composition comprising, hydrocolloid and elastomer. The dressing composition releases nitric oxide, which may have beneficial effects, when used on wounds or moist skin, with a substantially constant release rate over a long period of time. A dressing including a layer of the dressing composition has a backing layer and may have a release liner removably attached to the skin-contacting surface of the dressing layer.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: November 17, 2020
    Assignee: PQ Silicas UK Limited
    Inventors: Abraham Araya, Alan Reginald Minihan, Paul Matthew Robbins, Sonya Theresa Broderick, Michael J. Waring
  • Patent number: 10835637
    Abstract: The present invention relates to a triblock copolymer having a polyethylene glycol-poly(D,L-lactide)-polyethylene glycol skeleton.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: November 17, 2020
    Assignees: 3-D Matrix, Ltd. (Tokyo, Japan), Tokyo University of Science Foundation
    Inventors: Hidenori Otsuka, Daisuke Matsukuma, Noriaki Matsuda
  • Patent number: 10835638
    Abstract: A block copolymer including a plurality of polymeric chains and a plurality of cross-linking compound residues linking together the plurality of polymeric chains. The plurality of polymeric chains forms a plurality of hard domains and a plurality of soft domains. Each polymeric chain includes a plurality of soft segments and a plurality of hard segments. The plurality of soft segments includes a polyisobutylene diol or diamine residue. The plurality of soft segments forms the plurality of soft domains. The plurality of hard segments including a diisocyanate residue. The plurality of hard segments forms the plurality of hard domains. The cross-linking compound residues link together the hard segments of the plurality of polymeric chains.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: November 17, 2020
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Joseph T. Delaney, Jr., David R. Wulfman, Patrick Willoughby, Andrew J. Ro
  • Patent number: 10835639
    Abstract: Compositions and blends of biopolymers and copolymers are described, along with their use to prepare biocompatible scaffolds and surgically implantable devices for use in supporting and facilitating the repair of soft tissue injuries.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: November 17, 2020
    Assignee: EMBODY INC.
    Inventors: Michael Francis, Nathan Kemper, Hilary Wriggers
  • Patent number: 10835640
    Abstract: The invention relates to resorbable crosslinked form stable membrane which comprises a composite layer of collagen material and inorganic ceramic particles containing 1.5 to 3.5 weight parts of inorganic ceramic for 1 weight part of collagen material, sandwiched between two layers of elastic pretensed collagen material (collagen material that has been stretched such as to be in the linear/elastic region of the stress-strain curve), the collagen material comprising 50-100% (w/w) collagen and 0-50% (w/w) elastin, and has shape and dimensions suitable for use in human tissue regeneration outside the oral cavity in rhinoplasty, postlateral spinal fusion or orbital reconstruction.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: November 17, 2020
    Assignee: Geistlich Pharma AG
    Inventors: Niklaus Stiefel, Sergej Stenzel, Raphael Kaufmann
  • Patent number: 10835641
    Abstract: A porous material and preparation method thereof is provided. The material includes a material body. The body consists of pore cavities classified according to pore size of material and cavity walls surrounding to form the pore cavities. The lower-level pore cavities are arranged on the cavity walls of the upper-level pore cavities framed by surrounding a three-dimensional space. All the pore cavities are interconnected. The preparation method is: mixing raw powders with pore-forming agent for the smallest-level pore cavities of porous material to formulate slurry; uniformly filling the slurry into polymer material support to form green body and get dried and smashed to obtain mixed grains; uniformly mixing the mixed grains with pore-forming agent for upper-level pore cavities greater than the smallest-level pore cavities of porous material to make compact green body; performing vacuum sintering; performing the conventional follow-up treatment according to the raw materials process of porous material.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: November 17, 2020
    Assignee: CHONGQING RUNZE PHARMACEUTICALS CO., LTD.
    Inventor: Lei Ye
  • Patent number: 10835642
    Abstract: The present disclosure relates to compositions useful in synthetic bone graft applications. Particularly, the disclosure teaches moldable bone graft compositions, methods of making said compositions, and methods of utilizing the same.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: November 17, 2020
    Assignee: Bioventus, LLC
    Inventors: John E. Brunelle, Russell L. Cook, Duraid S. Antone
  • Patent number: 10835643
    Abstract: A drug coating layer on a non-porous nylon elastomer balloon substrate surface comprising a plurality of elongated bodies with long axes wherein each elongated body is formed of a crystal of a water-insoluble drug and is independently formed on the substrate surface, wherein the long axes of the elongated bodies are substantially linear in shape, and the long axes of the elongated bodies form an angle in a predetermined range with respect to a substrate plane with which the long axis of the elongated body intersects. The drug coating layer can provide low toxicity and a high intravascular stenosis inhibitory effect.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: November 17, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Keiko Yamashita, Hiroshi Goto, Shigenori Nozawa, Katsumi Morimoto
  • Patent number: 10835644
    Abstract: The present invention provides surface-modified metals such as metal medical devices, e.g., guide wires, syringe needles, and metal tubes in medical devices or equipment, in which a lubricant layer is firmly bonded to the surface to impart lubricity to the surface, and further to improve the durability of the lubricant layer on the surface, thereby reducing deterioration of sliding properties, as well as methods for modifying a metal surface. The present invention relates to a surface-modified metal having a surface at least partially treated by polymerizing a monomer in the presence of a hydrogen abstraction type photopolymerization initiator.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: November 17, 2020
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventors: Yasuhisa Minagawa, Takefumi Nakashita
  • Patent number: 10835645
    Abstract: Medical grade yarns, medical devices constructed of such yarns, and methods for making such yarns and devices are described. Polyester drawn fibers, and more particularly high strength and high tenacity micro polyester fibers for use in medical devices, and methods of preparing the same are provided.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: November 17, 2020
    Assignee: RxFiberLLC
    Inventor: Robert D. Torgerson
  • Patent number: 10835646
    Abstract: A system for preventing thrombosis in an implantable medical device includes an implantable medical device sized for implantation at least partially within a patient's body. The device includes an at least partially electrically conductive portion that is disposed within a patient's body upon implantation, an electrode coupled to the electrically conductive portion of the device; and a power source coupled to the electrode. The power source provides a negative electric charge to the at least partially electrically conductive portion for an indefinite period of time. The device may be configured to resist thrombosis, infection, and/or undesired tissue growth via the charged conductive portion once implanted. Exemplary embodiments of the implantable medical device include a hemodialysis vasculature graft, a dialysis catheter, a coronary artery, and a heart valve.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: November 17, 2020
    Inventor: Timothy J. Ryan
  • Patent number: 10835647
    Abstract: A digitally controlled aspirator is provided with a processor that allows the user to select operating conditions including one or more default settings. The processor further includes sensors for sensing operational and environmental conditions and adjusts the operation of the aspirator to reflect the sensed conditions.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: November 17, 2020
    Assignee: ZOLL Medical Corporation
    Inventors: Leslie H. Sherman, George Beck, Richard Goetzl, Dorian LeCroy
  • Patent number: 10835648
    Abstract: A surgical suction device that uses positive pressure gas is shown and described. The surgical suction device includes an air amplifier. The air amplifier includes a structure defining a generally cylindrical cavity having a first opening at a first end and a second opening at a second end. The cylindrical cavity is defined by an inner wall of the cavity. The air amplifier includes an annular opening in the inner wall near the first end. The annular opening defines a jet opening adapted to allow a pressurized gas to flow out of the annular opening such that a low pressure region is produced at the first end and an amplified flow is produced at the second end. The annular opening is further configured such that the pressurized gas enters the cavity at an angle with respect to the inner wall of the cavity that is towards the second end.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: November 17, 2020
    Assignee: CONMED CORPORATION
    Inventors: Noah Mark Minskoff, James Jackson, Elisabeth Jacques Leeflang, Aaron Olafur Laurence Philippsen
  • Patent number: 10835649
    Abstract: A surgical suction device that uses positive pressure gas is shown and described. The surgical suction device includes an air amplifier. The air amplifier includes a structure defining a generally cylindrical cavity having a first opening at a first end and a second opening at a second end. The cylindrical cavity is defined by an inner wall of the cavity. The air amplifier includes an annular opening in the inner wall near the first end. The annular opening defines a jet opening adapted to allow a pressurized gas to flow out of the annular opening such that a low pressure region is produced at the first end and an amplified flow is produced at the second end. The annular opening is further configured such that the pressurized gas enters the cavity at an angle with respect to the inner wall of the cavity that is towards the second end.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: November 17, 2020
    Assignee: Conmed Corporation
    Inventors: Noah Mark Minskoff, James Jackson, Elisabeth Jacques Leeflang, Aaron Olafur Laurence Philippsen
  • Patent number: 10835650
    Abstract: A device for separation and collection of tissue from an effluent stream of tissue and carrier fluid generated in a medical procedure comprises a housing (600) having an upper wall (601a), a lower wall (602a), a circumferential wall (612) extending between the upper wall and lower wall, an inlet aperture 606a for receiving the effluent stream and an outlet aperture (607a) for discharge of filtered fluid. The housing encloses a filter member (603a) positioned between said upper wall and said lower wall and comprising at least one filter receptacle (615), the upper wall comprising a viewing window (604) for viewing tissue collected in the filter member. The inlet aperture is located beneath the filter member, and the device comprises a fluid pathway (628) for delivering effluent stream received through the inlet aperture into a said filter receptacle from above the filter member. The device can be compact whilst nonetheless allowing visualisation of collected tissue.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: November 17, 2020
    Assignee: ARC MEDICAL DESIGN LIMITED
    Inventor: Patrick Axon
  • Patent number: 10835651
    Abstract: An introducer set (1) for providing vascular access in a patient's body comprises an introducer sheath (10) and a dilator (20). The introducer sheath (10) has a tubular body (11) made of flexible material with a distal portion (12), a proximal portion (13) and an inner surface, the proximal portion (13) being configured to be inserted into a patients vessel to allow a medical device (100) to be inserted through the introducer sheath (10) into the patient's vessel. At least one of the dilator (20) and the introducer sheath (10) comprises a stiffening structure (25) imparting stiffness to the tubular body (11) of the introducer sheath (10), wherein said stiffening structure (25) can be released, removed or otherwise deactivated.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: November 17, 2020
    Assignee: ABIOMED EUROPE GMBH
    Inventors: Adrian Moran, Thorsten Siess, Walid Aboulhosn
  • Patent number: 10835652
    Abstract: A magnetically-levitated blood pump with an optimization method that enables miniaturization and supercritical operation. The blood pump includes an optimized annular blood gap that increases blood flow and also provides a reduction in bearing stiffness among the permanent magnet bearings. Sensors are configured and placed optimally to provide space savings for the motor and magnet sections of the blood pump. Rotor mass is increased by providing permanent magnet placement deep within the rotor enabled by a draw rod configuration.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: November 17, 2020
    Assignee: Worldheart Corporation
    Inventors: Michael R. Ricci, James F. Antaki, Josiah E. Verkaik, David B. Paden, Shaun T. Snyder, Bradley E. Paden, Jingchun Wu
  • Patent number: 10835653
    Abstract: A fluid pump device changeable in diameter is provided. The device has a pump housing which is changeable in diameter and with a rotor which is changeable in diameter. The device has at least one delivery element for fluid, as well as a drive shaft on which the rotor is rotatably mounted. A bearing arrangement is arranged on the drive shaft or its extension, at the distal end of the drive shaft behind the rotor seen from the proximal end of the drive shaft. The bearing arrangement has struts, which elastically brace between a hub of the bearing arrangement and the pump housing.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: November 17, 2020
    Assignee: ECP ENTWICKLUNGSESELLSCHAFT MBH
    Inventor: Reiner Liebing
  • Patent number: 10835654
    Abstract: The invention generally relates to heart pump systems. In some embodiments, a pressure sensor is provided with a heart pump, either at the inflow or the outflow of the blood pump. The heart pump may further include a flow estimator based on a rotor drive current signal delivered to the rotor. Based on the rotor drive current signal, a differential pressure across the pump may be calculated. The differential pressure in combination with the pressure measurements from the pressure sensor may be used to calculate pressure on the opposite side of the pump from the pressure sensor. In some embodiments, the pressure sensor is located at the outflow of the pump and the pump is coupled with the left ventricle. The differential pressure and pressure measurement may be used to calculate a left ventricular pressure waveform of the patient. With such a measurement, other physiological parameters may be derived.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: November 17, 2020
    Assignee: TC1 LLC
    Inventors: Daniel I. Harjes, Kathryn B. Frederick, Eric Lee
  • Patent number: 10835655
    Abstract: A blood pump system includes a first implantable housing, an implantable blood pump independent from the first implantable housing, and a percutaneous extension. The first implantable housing includes a rechargeable power storage device. The implantable blood pump supplements the pumping function of a heart. The rechargeable power storage device supplies electrical power to the implantable blood pump. The percutaneous extension is coupled to the rechargeable power storage device and adapted to traverse the skin. The percutaneous extension is configured to releasably connect to an external power supply adapted to provide power for recharging or supplementing the rechargeable power storage device to power the implantable blood pump.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: November 17, 2020
    Assignee: TC1 LLC
    Inventors: Charles Dague, Kevin Bourque
  • Patent number: 10835656
    Abstract: A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: November 17, 2020
    Assignee: Medtronic, Inc.
    Inventors: Orhan Soykan, VenKatesh R. Manda, Martin T. Gerber, Christopher M. Hobot
  • Patent number: 10835657
    Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: November 17, 2020
    Assignee: NxStage Medical, Inc.
    Inventors: Jeffrey H. Burbank, Dennis M. Treu, Daniel J. Rubery, Jr., Scott W. Newell, James M. Brugger, William J. Schnell, William K. Weigel, Steven A. White, Mark T. Wyeth, Jerome James, David Desouza, Joseph E. Turk, Jr., Garrett Casey
  • Patent number: 10835658
    Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: November 17, 2020
    Assignee: NxStage Medical, Inc.
    Inventors: Jeffrey H. Burbank, Dennis M. Treu, Daniel J. Rubery, Jr., Scott W. Newell, James M. Brugger, William J. Schnell, William K. Weigel, Steven A. White, Mark T. Wyeth, Jerome James, David Desouza, Joseph E. Turk, Jr., Garrett Casey
  • Patent number: 10835659
    Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: November 17, 2020
    Assignee: NxStage Medical, Inc.
    Inventors: Jeffrey H. Burbank, Dennis M. Treu, Daniel J. Rubery, Jr., Scott W. Newell, James M. Brugger, William J. Schnell, William K. Weigel, Steven A. White, Mark T. Wyeth, Jerome James, David Desouza, Joseph E. Turk, Jr., Garrett Casey
  • Patent number: 10835660
    Abstract: The present invention relates to a dialysis solution containing bicarbonate, calcium and phosphate, wherein the dialysis solution contains phosphate having a concentration in the range from up to 0.4 mmol/l, preferably in the range from up to 0.375 mmol/l, or in the range from up to 0.25 mmol/l, and particularly preferably in the range from up to 0.2 mmol/l.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: November 17, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Jochen Huppert, Pascal Mathis, Robert Berlich
  • Patent number: 10835661
    Abstract: A blood gas analysis method (100) is provided for determining the partial pressure of oxygen of arterial blood exiting an oxygenator, wherein the oxygenator generates arterial blood by exposing venous blood to an oxygenation gas and releases excess oxygenation gas as exhaust gas. The method (100) comprises a step (140) of determining an estimate of the partial pressure of oxygen in the exhaust gas, a step (150) of determining the blood oxygen uptake in the oxygenator, and a step (160) of determining the partial pressure of oxygen in the arterial blood by adjusting the estimate using the blood oxygen uptake value. Used in a clinical setting, the method (100) allows a more accurate output of the partial pressure of oxygen in the arterial blood to be provided, which facilitates oxygenator operation.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: November 17, 2020
    Assignee: Spectrum Medical Ltd.
    Inventor: Stephen Turner
  • Patent number: 10835662
    Abstract: According to embodiments, priming systems, methods, and devices are disclosed which allow medical treatment devices which pump fluid to be primed with minimal operator intervention and a high level of convenience. A blood circuit with a filter fitted with one or more air vents on a non-blood compartment is attached to a treatment system and priming fluid pumped slowly through the blood circuit in a loop. The source of fluid may be elevated, or the pumping may generate pressure, such that priming fluid is forced through the membrane of the filter and out the air vent(s). In embodiments, the vents are hydrophobic which prevent fluid from being ejected, so the priming system can run without intervention.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: November 17, 2020
    Assignee: NxStage Medical, Inc.
    Inventors: James M. Brugger, William J. Schnell
  • Patent number: 10835663
    Abstract: A subcutaneous implantable device for guiding a vascular access member, the device including a channel defined by a through-hole in the device, wherein the channel is configured to guide the vascular access member there-through to a vascular site; and anchoring means adapted for fixedly attaching, in a form of using suture, tissue ingrowth, tissue encapsulation or tissue adhesion, the device to at least one of a dermis or a subcutaneous tissue at a position underneath the dermis to allow repeated access of the vascular access member through the channel to the vascular site, wherein the device is dimensioned to allow the device to be attached through the anchoring means for anchoring the entire device at a distance away from the vascular site, A method of creating scar tissue track for vascular access is also disclosed where the subcutaneous implantable device for guiding vascular access member is first implanted sub-dermally, the dermis is palpated to feel for the device location and orientation, the guiding
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: November 17, 2020
    Assignees: Agency for Science, Technology and Research, Singapore Health Services Pte Ltd
    Inventors: Ruey Feng Peh, Soo Ghim Lim, Yee Han Kuan, Yanling Toh, Hsien Ts'ung Tay, Seck Guan Tan
  • Patent number: 10835664
    Abstract: The invention comprises an implantable cell device that includes a membrane defining and enclosing a chamber; a distance body within the chamber for reducing the diffusion distance for a biological active factor to or across the membrane; and a support scaffold within the chamber for increasing the cell support surface area per unit volume of the chamber for distributing cells.
    Type: Grant
    Filed: April 30, 2017
    Date of Patent: November 17, 2020
    Assignee: Gloriana Therapeutics
    Inventors: Lars Ulrik Wahlberg, Jens Tornøe
  • Patent number: 10835665
    Abstract: A manually openable clamping holder for releasably fixing a single-use medical device to a medical treatment apparatus has a sensor for detecting the position of the clamping jaws of the clamping holder. With the clamping holder, the correct equipping of a medical treatment apparatus with the appropriate single-use device can be monitored economically and with simple operation.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: November 17, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventor: Nicolas Beisser