Patents Issued in November 17, 2020
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Patent number: 10835616Abstract: The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion —(CH2CH2O)n—, in which n is a number of six or more; and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.Type: GrantFiled: October 8, 2015Date of Patent: November 17, 2020Assignee: POLYTHERICS LIMITEDInventors: Antony Godwin, George Badescu, Matthew Bird, Penny Bryant, David Morris, Mark Frigerio
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Patent number: 10835617Abstract: A method of producing synergistic and enhanced efficacy in treating a disease in a subject includes providing an antibody, the antibody being a classic antibody or a modified biologic molecule that blocks a first target in the subject; providing a drug, the drug being a small molecule agent that blocks the first target or a second target in the subject; connecting the antibody and the drug with a linker to form an Antibody-Drug Synergism (ADS) compound; and treating the disease with the ADS compound. The linker is hydrolyzed in the subject over a certain time so that both the antibody and the drug exert their functions simultaneously, and the ADS compound confers better efficacy than either the antibody or the drug alone due to a synergism of the ADS compound.Type: GrantFiled: February 2, 2017Date of Patent: November 17, 2020Assignee: ADS THERAPEUTICS LLCInventors: Jinsong Ni, Rong Yang
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Patent number: 10835618Abstract: The present invention relates to an isolated specific binding member capable of binding sialyl-di-Lewisa, and associated treatments and pharmaceutical compositions for treatment of cancer.Type: GrantFiled: August 25, 2016Date of Patent: November 17, 2020Inventors: Lindy Gillian Durrant, Mireille Vankemmelbeke, Silvana Tivadar, Tina Parsons, Richard McIntosh
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Patent number: 10835619Abstract: Provided herein is a tumor associated macrophage (TAM)-targeting liposome. The liposome has a lipid bilayer, a targeting agent associated with the lipid bilayer, and a repolarizing agent associated with the lipid bilayer. The targeting agent optionally comprises an antibody or fragment thereof that selectively binds a TAM, whereas the repolarizing agent repolarizes the TAM upon binding of the TAM by the targeting agent. Also provided is a pharmaceutical composition comprising the TAM-targeting liposomes and a method of treating a subject with cancer with the compositions or liposomes described herein.Type: GrantFiled: August 15, 2017Date of Patent: November 17, 2020Assignee: Verily Life Sciences LLCInventors: Stephen Morton, Graziella Solinas
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Patent number: 10835620Abstract: This invention is generally related to novel compositions for treating or preventing heart failure. Specifically, the disclosure provides a composition comprising an amino-terminal domain of Beta.adrenergic receptor kinase-1 (Beta.ARKnt) peptide, or a nucleic acid encoding Beta.ARKnt. Further disclosed are methods of using the compositions for treating or preventing heart failure in a subject or for altering Beta.-adrenergic receptor (Beta.AR) density in a subject.Type: GrantFiled: June 5, 2017Date of Patent: November 17, 2020Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Walter J. Koch, Sarah M. Schumacher-Bass
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Patent number: 10835621Abstract: The present invention relates to a bicistronic expression vector for silencing a gene specifically in astrocytes and neurons, comprising two expression cassettes comprising a first and a second silencer sequence, respectively, wherein the expression of said first silencer sequence within astrocytes is regulated by an astrocyte-specific promoter and the expression of said second silencer sequence within neurons is regulated by a neuron-specific promoter. In a preferred embodiment, said first and second silencer sequences are SOD1 silencer sequences. Pharmaceutical composition comprising said bicistronic vector and the use of the same in the treatment of motoneuron diseases are further described.Type: GrantFiled: July 22, 2016Date of Patent: November 17, 2020Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Julianne Aebischer, Bernard Schneider, Cylia Rochat
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Patent number: 10835622Abstract: The invention is a simplified model on kidney rejection in animals and its setting approach. The method involves isolating dendritic cells from male mice and isolating T cells from female mice and then using the naive T cells in vitro to culture concurrently with male dendritic cells. Those activated T cells from female origin were injected into renal cortex in male mice for the purpose of attacking renal cortex. The animal model simulates the renal transplant rejection method to enable effective induction of renal transplant immune reaction.Type: GrantFiled: August 8, 2017Date of Patent: November 17, 2020Assignees: NATIONAL YANG-MING UNIVERSITY, TAIPEI VETERANS GENERAL HOSPITAL, TAICHUNG VETERANS GENERAL HOSPITALInventors: Der-Cheng Tarng, Nien-Jung Chen, Shuo-chun Weng
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Patent number: 10835623Abstract: Provided herein are examples of metal chelating ligands that have high affinity for manganese. The resultant metal complexes can be used as MRI contrast agents, and can be functionalized with moieties that bind to or cause relaxivity change in the presence of biochemical targets.Type: GrantFiled: August 12, 2016Date of Patent: November 17, 2020Assignee: The General Hospital CorporationInventors: Eric M. Gale, Peter Caravan
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Patent number: 10835624Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.Type: GrantFiled: July 21, 2017Date of Patent: November 17, 2020Assignees: AC IMMUNE S.A., LIFE MOLECULAR IMAGING SAInventors: Heiko Kroth, Jérôme Molette, Vincent Darmency, Hanno Schieferstein, Andre Müller, Heribert Schmitt-Willich, Mathias Berndt, Felix Oden, Emanuele Gabellieri
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Patent number: 10835625Abstract: The present invention provides radiolabeled trimethoprim which are useful in imaging tests such as PET scans. The compounds show robust bacterial uptake in vitro and identify infections from inflammation or tumor when administered to a subject. The compounds show rapid and sensitive detection of Ec DHFR containing tumors from control tumors and background tissue. In one aspect, a compound having the structure of formula (I) is provided or a pharmaceutically acceptable salt or prodrug thereof, wherein R is defined herein. Also provided are compositions containing these compounds, positron emission tomography reporter probe comprising these compounds, and methods of imaging a bacterial infection, tracking or monitoring bacteria, distinguishing a bacterial infection from inflammation or tumor, monitoring genetically fused protein expression, and monitoring genetically engineered cells in clinical scenarios such as immunotherapy for cancer treatment.Type: GrantFiled: July 15, 2019Date of Patent: November 17, 2020Assignee: The Trustees of the University of PennsylvaniaInventors: Mark Sellmyer, Robert H. Mach, David A. Mankoff, Iljung Lee
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Patent number: 10835626Abstract: Systems and methods for combined HINS and non-HINS lighting for surface disinfection. A lighting system controller is provided, which includes a memory, an i/o interface, and an electronic processor. The processor is configured to retrieve from the memory at least one characteristic of an area to be disinfected; determine, based on a signal received from a first sensor positioned to sense the presence of a person in the area, whether a person is present in the area; and, when a person is present in the area, determine a first drive signal based on the at least one characteristic and the presence of the person, and a second drive signal based on the presence of the person in the area and the first drive signal. The processor provides the first drive signal to drive to a HINS LED array and the second drive signal to drive a non-HINS LED array.Type: GrantFiled: October 30, 2017Date of Patent: November 17, 2020Assignee: Hubbell IncorporatedInventors: Pritam Yadav, Thomas James Veltri
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Patent number: 10835627Abstract: A light emitting device which inactivates microorganisms is disclosed. The light emitting device may include a flexible light emitting layer emitting a light; and a transparent or translucent layer over the flexible light emitting layer. The light may travel through and exit an exterior surface of the transparent or translucent layer, creating an exiting light. The exiting light exiting the transparent or translucent layer may have at least a portion thereof having a wavelength in a range of 380 to 420 nanometers, and may disinfect the exterior surface of the transparent or translucent layer. The light emitting device may be used alone to create a self-disinfecting high touch surface, e.g., on a door, or may be shaped to mate with other structure to create a disinfecting high touch surface.Type: GrantFiled: June 5, 2018Date of Patent: November 17, 2020Assignee: Vital Vio, Inc.Inventors: Nicholas Jones, Colleen Costello, Cori Winslow, Robert Barron, William Grambo, Jorel Lalicki
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Patent number: 10835628Abstract: A germicidal system for use in disinfecting a human interface device includes at least one human interface device. One or more ultra-violet (UV) light sources are used in proximity to the at least one human interface device for disinfecting a touch surface of the human interface device below a surgical grade sterilization. A memory for storing usage data of the at least one UV light source. At least one server is used for providing a central storage location for usage data supplied from the memory and a computer is used in communication with the at least one server for controlling the operational parameters of the at least one UV light source.Type: GrantFiled: May 24, 2019Date of Patent: November 17, 2020Assignee: UV Partners, Inc.Inventor: Theodore John Cole
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Patent number: 10835629Abstract: A device for generating singlet oxygen is provided. The device has elongated posts extending from a surface, the lateral sides of which have particles with a sensitizer that converts triplet oxygen to single oxygen upon exposure to light. An optical fiber conveys light to the sensitizer and a gas supply tube conveys oxygen to the sensitizer. The device is configured to keep the sensitizer from contacting external fluids, such as saliva.Type: GrantFiled: October 10, 2017Date of Patent: November 17, 2020Assignee: Research Foundation of the City University of New YorkInventors: Alan M. Lyons, Alexander Greer, QianFeng Xu
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Patent number: 10835630Abstract: An air freshener for vehicles including a main body for holding a container for volatile substances and a foldable clip which can be placed in a substantially perpendicular position with respect to the main body. The foldable clip is rotatable with respect to the main body. The clip is always connected with the main body, so that it is sold with it occupying a reduced space in the package. The clip can be rotated to be adapted to any kind of ventilation grids.Type: GrantFiled: November 29, 2016Date of Patent: November 17, 2020Assignee: ZOBELE HOLDING S.P.A.Inventors: Stefano Deflorian, Walter Sordo
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Patent number: 10835631Abstract: A photocatalytic element including: a photocatalytic layer containing at least one photocatalytic material; and a light emitting source in optical communication with the photocatalytic material, the light emitting source disposed sufficiently proximal to the photocatalytic material to raise the surface temperature of at least some of the photocatalytic material to a temperature between 10° C. and 90° C. is provided.Type: GrantFiled: October 6, 2016Date of Patent: November 17, 2020Assignee: Nitto Denko CorporationInventors: Ekambaram Sambandan, Sazzadur Rahman Khan, Takuya Fukumura, Hiroyuki Katayama
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Patent number: 10835632Abstract: An autoclave with an upper hatch and a bottom hatch is terminated with elliptical end caps has an agitator placed inside it. The autoclave is inclined in relation to the ground plane. An external jacket is mounted on the cylindrical section of the internal pressure chamber. The jacket is divided into pressure-separated parts Inside the internal pressure chamber a paddle agitator shaft is mounted. The agitator mounting arrangement is out-of-alignment in relation to the axis of symmetry of the autoclave cylindrical section The size of the shift does not exceed ? of the radial length of the cross-section of the cylindrical section of the internal pressure chamber. The agitator's paddles has two shields shifted in the agitator's axis of symmetry in relation to its paddle by a phase angle equal to 90°. The shield height does not exceed ? of the height of the agitator's paddle.Type: GrantFiled: December 6, 2016Date of Patent: November 17, 2020Assignee: BIOELEKTRA GROUP S.A.Inventor: Eryk Jaroslaw Brajtling
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Patent number: 10835633Abstract: The present invention relates to novel and secure tampons that overcome the problems associated with conventional non-secure tampons, and methods of using the novel and secure tampons.Type: GrantFiled: July 12, 2017Date of Patent: November 17, 2020Assignee: THINK DO ITInventor: Suzanne Raina Natbony
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Patent number: 10835634Abstract: A process for agglomerating superabsorbent particles, wherein polymer particles having a particle size of 250 ?m or less are dispersed in a hydrophobic organic solvent, the dispersed polymer particles are mixed with an aqueous monomer solution, the total amount of water applied to the dispersed polymer particles being at least 100% by weight, based on the dispersed polymer particles, and the monomer solution is polymerized.Type: GrantFiled: March 24, 2016Date of Patent: November 17, 2020Assignee: BASF SEInventors: Tina Mark, Thomas Daniel, Erich Lutz, Stefan Molter
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Patent number: 10835635Abstract: A tissue adhesive with healing promotion properties formed from a mixture of natural polymers and an activating agent that enhances the adhesive properties of the natural polymer mixture is described. Use of an activating agent and a combination of the natural polymers is unique. The natural polymer tissue adhesive may be useful as a post-operative application for tonsillectomy or adenoidectomy surgery, as an internal tissue adhesive for surgery or wound repair or for application to a burn or skin donor site. For internal use, an optional treatment to improve resistance of the activated adhesive to body fluids is also described. The adhesive described not only functions as an adhesive but would also serve as a protective barrier when applied to surgery or skin sites. In addition, the natural polymers would promote healing due to the inherent properties of the polymers selected.Type: GrantFiled: May 31, 2018Date of Patent: November 17, 2020Assignee: HCS Innovation, LLCInventors: Ronnie Michael Hanes, Adele Lamping Hanes
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Patent number: 10835636Abstract: A dressing composition for use as a skin dressing comprises an elastomeric-adhesive composition, and a zeolite comprising releasably adsorbed nitric oxide. The zeolite may comprise a transition metal cation such as Co, Fe, Mn, Ni, Cu, Zn, Ag or a mixture thereof as an extra-framework metal cation, preferably Zn. The elastomeric adhesive composition may be a hydrocolloid-adhesive composition comprising, hydrocolloid and elastomer. The dressing composition releases nitric oxide, which may have beneficial effects, when used on wounds or moist skin, with a substantially constant release rate over a long period of time. A dressing including a layer of the dressing composition has a backing layer and may have a release liner removably attached to the skin-contacting surface of the dressing layer.Type: GrantFiled: August 13, 2014Date of Patent: November 17, 2020Assignee: PQ Silicas UK LimitedInventors: Abraham Araya, Alan Reginald Minihan, Paul Matthew Robbins, Sonya Theresa Broderick, Michael J. Waring
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Patent number: 10835637Abstract: The present invention relates to a triblock copolymer having a polyethylene glycol-poly(D,L-lactide)-polyethylene glycol skeleton.Type: GrantFiled: August 23, 2016Date of Patent: November 17, 2020Assignees: 3-D Matrix, Ltd. (Tokyo, Japan), Tokyo University of Science FoundationInventors: Hidenori Otsuka, Daisuke Matsukuma, Noriaki Matsuda
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Patent number: 10835638Abstract: A block copolymer including a plurality of polymeric chains and a plurality of cross-linking compound residues linking together the plurality of polymeric chains. The plurality of polymeric chains forms a plurality of hard domains and a plurality of soft domains. Each polymeric chain includes a plurality of soft segments and a plurality of hard segments. The plurality of soft segments includes a polyisobutylene diol or diamine residue. The plurality of soft segments forms the plurality of soft domains. The plurality of hard segments including a diisocyanate residue. The plurality of hard segments forms the plurality of hard domains. The cross-linking compound residues link together the hard segments of the plurality of polymeric chains.Type: GrantFiled: August 16, 2018Date of Patent: November 17, 2020Assignee: Cardiac Pacemakers, Inc.Inventors: Joseph T. Delaney, Jr., David R. Wulfman, Patrick Willoughby, Andrew J. Ro
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Patent number: 10835639Abstract: Compositions and blends of biopolymers and copolymers are described, along with their use to prepare biocompatible scaffolds and surgically implantable devices for use in supporting and facilitating the repair of soft tissue injuries.Type: GrantFiled: March 13, 2020Date of Patent: November 17, 2020Assignee: EMBODY INC.Inventors: Michael Francis, Nathan Kemper, Hilary Wriggers
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Patent number: 10835640Abstract: The invention relates to resorbable crosslinked form stable membrane which comprises a composite layer of collagen material and inorganic ceramic particles containing 1.5 to 3.5 weight parts of inorganic ceramic for 1 weight part of collagen material, sandwiched between two layers of elastic pretensed collagen material (collagen material that has been stretched such as to be in the linear/elastic region of the stress-strain curve), the collagen material comprising 50-100% (w/w) collagen and 0-50% (w/w) elastin, and has shape and dimensions suitable for use in human tissue regeneration outside the oral cavity in rhinoplasty, postlateral spinal fusion or orbital reconstruction.Type: GrantFiled: June 1, 2018Date of Patent: November 17, 2020Assignee: Geistlich Pharma AGInventors: Niklaus Stiefel, Sergej Stenzel, Raphael Kaufmann
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Patent number: 10835641Abstract: A porous material and preparation method thereof is provided. The material includes a material body. The body consists of pore cavities classified according to pore size of material and cavity walls surrounding to form the pore cavities. The lower-level pore cavities are arranged on the cavity walls of the upper-level pore cavities framed by surrounding a three-dimensional space. All the pore cavities are interconnected. The preparation method is: mixing raw powders with pore-forming agent for the smallest-level pore cavities of porous material to formulate slurry; uniformly filling the slurry into polymer material support to form green body and get dried and smashed to obtain mixed grains; uniformly mixing the mixed grains with pore-forming agent for upper-level pore cavities greater than the smallest-level pore cavities of porous material to make compact green body; performing vacuum sintering; performing the conventional follow-up treatment according to the raw materials process of porous material.Type: GrantFiled: August 15, 2016Date of Patent: November 17, 2020Assignee: CHONGQING RUNZE PHARMACEUTICALS CO., LTD.Inventor: Lei Ye
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Patent number: 10835642Abstract: The present disclosure relates to compositions useful in synthetic bone graft applications. Particularly, the disclosure teaches moldable bone graft compositions, methods of making said compositions, and methods of utilizing the same.Type: GrantFiled: July 27, 2018Date of Patent: November 17, 2020Assignee: Bioventus, LLCInventors: John E. Brunelle, Russell L. Cook, Duraid S. Antone
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Patent number: 10835643Abstract: A drug coating layer on a non-porous nylon elastomer balloon substrate surface comprising a plurality of elongated bodies with long axes wherein each elongated body is formed of a crystal of a water-insoluble drug and is independently formed on the substrate surface, wherein the long axes of the elongated bodies are substantially linear in shape, and the long axes of the elongated bodies form an angle in a predetermined range with respect to a substrate plane with which the long axis of the elongated body intersects. The drug coating layer can provide low toxicity and a high intravascular stenosis inhibitory effect.Type: GrantFiled: January 12, 2018Date of Patent: November 17, 2020Assignee: TERUMO KABUSHIKI KAISHAInventors: Keiko Yamashita, Hiroshi Goto, Shigenori Nozawa, Katsumi Morimoto
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Patent number: 10835644Abstract: The present invention provides surface-modified metals such as metal medical devices, e.g., guide wires, syringe needles, and metal tubes in medical devices or equipment, in which a lubricant layer is firmly bonded to the surface to impart lubricity to the surface, and further to improve the durability of the lubricant layer on the surface, thereby reducing deterioration of sliding properties, as well as methods for modifying a metal surface. The present invention relates to a surface-modified metal having a surface at least partially treated by polymerizing a monomer in the presence of a hydrogen abstraction type photopolymerization initiator.Type: GrantFiled: October 8, 2014Date of Patent: November 17, 2020Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.Inventors: Yasuhisa Minagawa, Takefumi Nakashita
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Patent number: 10835645Abstract: Medical grade yarns, medical devices constructed of such yarns, and methods for making such yarns and devices are described. Polyester drawn fibers, and more particularly high strength and high tenacity micro polyester fibers for use in medical devices, and methods of preparing the same are provided.Type: GrantFiled: August 3, 2018Date of Patent: November 17, 2020Assignee: RxFiberLLCInventor: Robert D. Torgerson
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Patent number: 10835646Abstract: A system for preventing thrombosis in an implantable medical device includes an implantable medical device sized for implantation at least partially within a patient's body. The device includes an at least partially electrically conductive portion that is disposed within a patient's body upon implantation, an electrode coupled to the electrically conductive portion of the device; and a power source coupled to the electrode. The power source provides a negative electric charge to the at least partially electrically conductive portion for an indefinite period of time. The device may be configured to resist thrombosis, infection, and/or undesired tissue growth via the charged conductive portion once implanted. Exemplary embodiments of the implantable medical device include a hemodialysis vasculature graft, a dialysis catheter, a coronary artery, and a heart valve.Type: GrantFiled: March 27, 2012Date of Patent: November 17, 2020Inventor: Timothy J. Ryan
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Patent number: 10835647Abstract: A digitally controlled aspirator is provided with a processor that allows the user to select operating conditions including one or more default settings. The processor further includes sensors for sensing operational and environmental conditions and adjusts the operation of the aspirator to reflect the sensed conditions.Type: GrantFiled: November 30, 2017Date of Patent: November 17, 2020Assignee: ZOLL Medical CorporationInventors: Leslie H. Sherman, George Beck, Richard Goetzl, Dorian LeCroy
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Patent number: 10835648Abstract: A surgical suction device that uses positive pressure gas is shown and described. The surgical suction device includes an air amplifier. The air amplifier includes a structure defining a generally cylindrical cavity having a first opening at a first end and a second opening at a second end. The cylindrical cavity is defined by an inner wall of the cavity. The air amplifier includes an annular opening in the inner wall near the first end. The annular opening defines a jet opening adapted to allow a pressurized gas to flow out of the annular opening such that a low pressure region is produced at the first end and an amplified flow is produced at the second end. The annular opening is further configured such that the pressurized gas enters the cavity at an angle with respect to the inner wall of the cavity that is towards the second end.Type: GrantFiled: November 11, 2015Date of Patent: November 17, 2020Assignee: CONMED CORPORATIONInventors: Noah Mark Minskoff, James Jackson, Elisabeth Jacques Leeflang, Aaron Olafur Laurence Philippsen
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Patent number: 10835649Abstract: A surgical suction device that uses positive pressure gas is shown and described. The surgical suction device includes an air amplifier. The air amplifier includes a structure defining a generally cylindrical cavity having a first opening at a first end and a second opening at a second end. The cylindrical cavity is defined by an inner wall of the cavity. The air amplifier includes an annular opening in the inner wall near the first end. The annular opening defines a jet opening adapted to allow a pressurized gas to flow out of the annular opening such that a low pressure region is produced at the first end and an amplified flow is produced at the second end. The annular opening is further configured such that the pressurized gas enters the cavity at an angle with respect to the inner wall of the cavity that is towards the second end.Type: GrantFiled: November 11, 2015Date of Patent: November 17, 2020Assignee: Conmed CorporationInventors: Noah Mark Minskoff, James Jackson, Elisabeth Jacques Leeflang, Aaron Olafur Laurence Philippsen
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Patent number: 10835650Abstract: A device for separation and collection of tissue from an effluent stream of tissue and carrier fluid generated in a medical procedure comprises a housing (600) having an upper wall (601a), a lower wall (602a), a circumferential wall (612) extending between the upper wall and lower wall, an inlet aperture 606a for receiving the effluent stream and an outlet aperture (607a) for discharge of filtered fluid. The housing encloses a filter member (603a) positioned between said upper wall and said lower wall and comprising at least one filter receptacle (615), the upper wall comprising a viewing window (604) for viewing tissue collected in the filter member. The inlet aperture is located beneath the filter member, and the device comprises a fluid pathway (628) for delivering effluent stream received through the inlet aperture into a said filter receptacle from above the filter member. The device can be compact whilst nonetheless allowing visualisation of collected tissue.Type: GrantFiled: October 7, 2016Date of Patent: November 17, 2020Assignee: ARC MEDICAL DESIGN LIMITEDInventor: Patrick Axon
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Patent number: 10835651Abstract: An introducer set (1) for providing vascular access in a patient's body comprises an introducer sheath (10) and a dilator (20). The introducer sheath (10) has a tubular body (11) made of flexible material with a distal portion (12), a proximal portion (13) and an inner surface, the proximal portion (13) being configured to be inserted into a patients vessel to allow a medical device (100) to be inserted through the introducer sheath (10) into the patient's vessel. At least one of the dilator (20) and the introducer sheath (10) comprises a stiffening structure (25) imparting stiffness to the tubular body (11) of the introducer sheath (10), wherein said stiffening structure (25) can be released, removed or otherwise deactivated.Type: GrantFiled: January 7, 2016Date of Patent: November 17, 2020Assignee: ABIOMED EUROPE GMBHInventors: Adrian Moran, Thorsten Siess, Walid Aboulhosn
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Patent number: 10835652Abstract: A magnetically-levitated blood pump with an optimization method that enables miniaturization and supercritical operation. The blood pump includes an optimized annular blood gap that increases blood flow and also provides a reduction in bearing stiffness among the permanent magnet bearings. Sensors are configured and placed optimally to provide space savings for the motor and magnet sections of the blood pump. Rotor mass is increased by providing permanent magnet placement deep within the rotor enabled by a draw rod configuration.Type: GrantFiled: March 9, 2016Date of Patent: November 17, 2020Assignee: Worldheart CorporationInventors: Michael R. Ricci, James F. Antaki, Josiah E. Verkaik, David B. Paden, Shaun T. Snyder, Bradley E. Paden, Jingchun Wu
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Patent number: 10835653Abstract: A fluid pump device changeable in diameter is provided. The device has a pump housing which is changeable in diameter and with a rotor which is changeable in diameter. The device has at least one delivery element for fluid, as well as a drive shaft on which the rotor is rotatably mounted. A bearing arrangement is arranged on the drive shaft or its extension, at the distal end of the drive shaft behind the rotor seen from the proximal end of the drive shaft. The bearing arrangement has struts, which elastically brace between a hub of the bearing arrangement and the pump housing.Type: GrantFiled: March 29, 2019Date of Patent: November 17, 2020Assignee: ECP ENTWICKLUNGSESELLSCHAFT MBHInventor: Reiner Liebing
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Patent number: 10835654Abstract: The invention generally relates to heart pump systems. In some embodiments, a pressure sensor is provided with a heart pump, either at the inflow or the outflow of the blood pump. The heart pump may further include a flow estimator based on a rotor drive current signal delivered to the rotor. Based on the rotor drive current signal, a differential pressure across the pump may be calculated. The differential pressure in combination with the pressure measurements from the pressure sensor may be used to calculate pressure on the opposite side of the pump from the pressure sensor. In some embodiments, the pressure sensor is located at the outflow of the pump and the pump is coupled with the left ventricle. The differential pressure and pressure measurement may be used to calculate a left ventricular pressure waveform of the patient. With such a measurement, other physiological parameters may be derived.Type: GrantFiled: March 28, 2018Date of Patent: November 17, 2020Assignee: TC1 LLCInventors: Daniel I. Harjes, Kathryn B. Frederick, Eric Lee
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Patent number: 10835655Abstract: A blood pump system includes a first implantable housing, an implantable blood pump independent from the first implantable housing, and a percutaneous extension. The first implantable housing includes a rechargeable power storage device. The implantable blood pump supplements the pumping function of a heart. The rechargeable power storage device supplies electrical power to the implantable blood pump. The percutaneous extension is coupled to the rechargeable power storage device and adapted to traverse the skin. The percutaneous extension is configured to releasably connect to an external power supply adapted to provide power for recharging or supplementing the rechargeable power storage device to power the implantable blood pump.Type: GrantFiled: July 3, 2018Date of Patent: November 17, 2020Assignee: TC1 LLCInventors: Charles Dague, Kevin Bourque
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Patent number: 10835656Abstract: A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.Type: GrantFiled: January 7, 2019Date of Patent: November 17, 2020Assignee: Medtronic, Inc.Inventors: Orhan Soykan, VenKatesh R. Manda, Martin T. Gerber, Christopher M. Hobot
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Patent number: 10835657Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.Type: GrantFiled: April 11, 2019Date of Patent: November 17, 2020Assignee: NxStage Medical, Inc.Inventors: Jeffrey H. Burbank, Dennis M. Treu, Daniel J. Rubery, Jr., Scott W. Newell, James M. Brugger, William J. Schnell, William K. Weigel, Steven A. White, Mark T. Wyeth, Jerome James, David Desouza, Joseph E. Turk, Jr., Garrett Casey
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Patent number: 10835658Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.Type: GrantFiled: April 11, 2019Date of Patent: November 17, 2020Assignee: NxStage Medical, Inc.Inventors: Jeffrey H. Burbank, Dennis M. Treu, Daniel J. Rubery, Jr., Scott W. Newell, James M. Brugger, William J. Schnell, William K. Weigel, Steven A. White, Mark T. Wyeth, Jerome James, David Desouza, Joseph E. Turk, Jr., Garrett Casey
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Patent number: 10835659Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.Type: GrantFiled: April 11, 2019Date of Patent: November 17, 2020Assignee: NxStage Medical, Inc.Inventors: Jeffrey H. Burbank, Dennis M. Treu, Daniel J. Rubery, Jr., Scott W. Newell, James M. Brugger, William J. Schnell, William K. Weigel, Steven A. White, Mark T. Wyeth, Jerome James, David Desouza, Joseph E. Turk, Jr., Garrett Casey
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Patent number: 10835660Abstract: The present invention relates to a dialysis solution containing bicarbonate, calcium and phosphate, wherein the dialysis solution contains phosphate having a concentration in the range from up to 0.4 mmol/l, preferably in the range from up to 0.375 mmol/l, or in the range from up to 0.25 mmol/l, and particularly preferably in the range from up to 0.2 mmol/l.Type: GrantFiled: September 15, 2015Date of Patent: November 17, 2020Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBHInventors: Jochen Huppert, Pascal Mathis, Robert Berlich
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Patent number: 10835661Abstract: A blood gas analysis method (100) is provided for determining the partial pressure of oxygen of arterial blood exiting an oxygenator, wherein the oxygenator generates arterial blood by exposing venous blood to an oxygenation gas and releases excess oxygenation gas as exhaust gas. The method (100) comprises a step (140) of determining an estimate of the partial pressure of oxygen in the exhaust gas, a step (150) of determining the blood oxygen uptake in the oxygenator, and a step (160) of determining the partial pressure of oxygen in the arterial blood by adjusting the estimate using the blood oxygen uptake value. Used in a clinical setting, the method (100) allows a more accurate output of the partial pressure of oxygen in the arterial blood to be provided, which facilitates oxygenator operation.Type: GrantFiled: March 3, 2016Date of Patent: November 17, 2020Assignee: Spectrum Medical Ltd.Inventor: Stephen Turner
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Patent number: 10835662Abstract: According to embodiments, priming systems, methods, and devices are disclosed which allow medical treatment devices which pump fluid to be primed with minimal operator intervention and a high level of convenience. A blood circuit with a filter fitted with one or more air vents on a non-blood compartment is attached to a treatment system and priming fluid pumped slowly through the blood circuit in a loop. The source of fluid may be elevated, or the pumping may generate pressure, such that priming fluid is forced through the membrane of the filter and out the air vent(s). In embodiments, the vents are hydrophobic which prevent fluid from being ejected, so the priming system can run without intervention.Type: GrantFiled: May 11, 2018Date of Patent: November 17, 2020Assignee: NxStage Medical, Inc.Inventors: James M. Brugger, William J. Schnell
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Patent number: 10835663Abstract: A subcutaneous implantable device for guiding a vascular access member, the device including a channel defined by a through-hole in the device, wherein the channel is configured to guide the vascular access member there-through to a vascular site; and anchoring means adapted for fixedly attaching, in a form of using suture, tissue ingrowth, tissue encapsulation or tissue adhesion, the device to at least one of a dermis or a subcutaneous tissue at a position underneath the dermis to allow repeated access of the vascular access member through the channel to the vascular site, wherein the device is dimensioned to allow the device to be attached through the anchoring means for anchoring the entire device at a distance away from the vascular site, A method of creating scar tissue track for vascular access is also disclosed where the subcutaneous implantable device for guiding vascular access member is first implanted sub-dermally, the dermis is palpated to feel for the device location and orientation, the guidingType: GrantFiled: January 7, 2016Date of Patent: November 17, 2020Assignees: Agency for Science, Technology and Research, Singapore Health Services Pte LtdInventors: Ruey Feng Peh, Soo Ghim Lim, Yee Han Kuan, Yanling Toh, Hsien Ts'ung Tay, Seck Guan Tan
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Patent number: 10835664Abstract: The invention comprises an implantable cell device that includes a membrane defining and enclosing a chamber; a distance body within the chamber for reducing the diffusion distance for a biological active factor to or across the membrane; and a support scaffold within the chamber for increasing the cell support surface area per unit volume of the chamber for distributing cells.Type: GrantFiled: April 30, 2017Date of Patent: November 17, 2020Assignee: Gloriana TherapeuticsInventors: Lars Ulrik Wahlberg, Jens Tornøe
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Patent number: 10835665Abstract: A manually openable clamping holder for releasably fixing a single-use medical device to a medical treatment apparatus has a sensor for detecting the position of the clamping jaws of the clamping holder. With the clamping holder, the correct equipping of a medical treatment apparatus with the appropriate single-use device can be monitored economically and with simple operation.Type: GrantFiled: November 8, 2011Date of Patent: November 17, 2020Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBHInventor: Nicolas Beisser