Abstract: A clip-holder device for retaining and positioning an IV set tubing, and methods for using and kits including the clip-holder device.

Abstract: An intravenous fluid administration comfort and safety assist method may include deploying an intravenous fluid administration stand adjacent to a patient bed; suspending an intravenous fluid administration container on the intravenous fluid administration stand, the intravenous fluid administration container having an intravenous fluid administration line; obtaining an intravenous fluid administration comfort and safety assist device including a restraining member having a proximal restraining member end, a distal restraining member end and a line attachment member on the distal restraining member end, the distal restraining member end and the proximal restraining member end disposed within a common straight line; attaching the proximal restraining member end of the restraining member to the intravenous fluid administration stand; attaching the line attachment member on the distal restraining member end of the restraining member to the intravenous fluid administration line; and inserting the intravenous flui

Abstract: An adapter for releasably attaching a syringe to an injector. The adapter comprises a mounting mechanism positioned at a rear end of the adapter to mount the adapter in a desired position relative to a front wall of the injector; and a syringe carrier section adapted to seat at least a portion of the syringe. The syringe carrier section defines a first opening on a top thereof to allow placement of the syringe therein from the top and a second opening in a rear section thereof to allow the drive member of the injector to communicate forward force to the plunger. A cover portion extends over a rearward end of the first opening and has a first end configured to abut the flange of the syringe when the syringe is positioned within the syringe carrier section.

Abstract: Fill stations and base stations are provided for personal pump systems. The fill stations may be opened and closed to accept a reservoir and to allow fluid to be introduced into the reservoir for use with personal pump systems. The fill stations may hold the reservoir at a tilt relative to an underlying surface and may discourage overfilling of the reservoir. The filling stations may also include viewing windows having fluid lines marked thereon for indicating volume of fluid within the reservoir.

Abstract: Systems and methods for modulating delivery of a fluid medium to a selected site within a patient's body are described. A system includes a syringe for injecting the fluid medium, a delivery catheter including a conduit for delivering the fluid medium from outside of the body to the selected site within the body, a diversion reservoir configured to receive a portion of the fluid medium, and a flow diverter assembly disposed in a fluid medium flow path between the syringe and the delivery catheter. The flow diverter assembly is configured to divert the portion of the fluid medium from the chamber of the syringe away from the delivery of the medium through the delivery catheter conduit during injecting with the syringe. The flow diverter assembly simultaneously increases fluid medium flow resistance with increasing pressure level of the fluid medium passing into the flow diverter assembly.

Abstract: A method may include delivering insulin, using an insulin pump and a controller, over a first diurnal time period based on a baseline basal insulin rate stored in memory. The controller may receive blood glucose data to control delivery of insulin via the insulin pump in amounts variable from the baseline basal insulin rate to control blood glucose levels for a person with diabetes (PWD). The method may also include modifying the baseline basal insulin rate stored in the memory for a second diurnal time period that is at least 20 hours after the first diurnal period based on an amount of insulin actually delivered during the first diurnal time period.

Abstract: Systems and methods for integrating a continuous glucose sensor 12, including a receiver 14, a medicament delivery device 16, a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.

Abstract: Certain exemplary embodiments comprise can comprise an auto-injector, which can comprise: a vial configured to store and/or contain an injectable medicament, the vial defining a vial longitudinal axis, and a housing comprising the vial. In various embodiments, the injectable medicament can be a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, and/or nutritional supplement that is substantially ready for injection.

Abstract: Provided is an apparatus, system, and method for a nested syringe assembly. The nested syringe assembly (100) includes a first syringe (104) having a cylindrical body defining an inner diameter and a second syringe (102) having a cylindrical body defining an outer diameter. The outer diameter of the second syringe is less than the inner diameter of the first syringe. At least a portion of the cylindrical body of the second syringe is disposed within the cylindrical body of the first syringe.

Abstract: The invention relates to a device for inserting needles, including a body defined by a proximal end and a distal end, a mounting movably mounted inside the body, at least one needle secured to the mounting, a drive means suitable for driving the mounting towards said distal end, said mounting comprising a distal surface onto which the needle projects, said distal end comprising a contact area intended for contacting the tissue, the mounting being configured so as to reach a position, after activating the driving means, in which the distal surface thereof, relative to said proximal end, is more distant than said contact area, wherein the device is further configured so as to enable a gradual passive return movement of the mounting once said position has been reached.

Abstract: A push button safety injector includes a housing having a proximal end, a distal end spaced from the proximal end, and a longitudinal axis. An injection ram is positioned along the longitudinal axis and configured to actuate a fluid chamber. The injection ram is biased toward the distal end in an initial position. A sliding member is configured to retain the injection ram in the initial position. A safety member confines radial movement of the sliding member in the initial position and allows radial movement of the sliding member in an armed position. A button is moveable between an initial extended position and a depressed position. The button is engagable with the sliding member and configured to move the sliding member radially in the armed position. The sliding member releases the injection ram when the button is in the depressed position.

Abstract: An auto injector (4) for administering injection of a medicament from a cartridge (700) containing the medicament, the auto injector comprising: a cartridge receiver (300) with a cartridge receiver compartment (302) configured to receive a cartridge assembly (600) with at least one cartridge retention member (808) when inserted through a cartridge receiver opening (302) along a longitudinal axis; and an ejector (200) configured to support the cartridge assembly (600) by being suspended to move along the longitudinal direction and being spring-loaded in the direction opposite of the receiving direction.

Abstract: The invention is a single use delivery device configured to enable reconstitution of a lyophilized agent (e.g., vaccine, drug, medicament, etc.) stored within for subsequent delivery of the reconstituted fluid agent to a patient in a controlled manner and without requiring specialized skill in reconstituting the agent or administering delivery of such agent. The delivery device is prefilled with an individual dose of a lyophilized agent and configured to be filled on-site and in the field with a dose of diluent for reconstitution of the lyophilized agent, while remaining sterile and preventing the potential for contamination during the filling process. The delivery device is further configured to be rendered incapable of reuse followings its intended use of delivering the fluid agent to a patient, thereby preventing reuse of the device and reducing the risk of the spreading blood-borne diseases through reuse.

Abstract: A needleless injector includes a cap, an injection system, a body, a gas generator, and a percussion device. The body is covered by the cap and is mounted to slide relative to the cap. The percussion device includes a striker that is slidingly mounted along a sliding axis between a rest position and a percussion position and a lock mechanism. The lock mechanism includes a lug and a retention tab. The lug projects from a peripheral face of the striker along an axis that is perpendicular to the sliding axis and has a first support ramp. The retention tab is attached to the cap, and has a second support ramp. The ramps are configured to move the retention tab radially when pushed by the striker from a retaining position to a release position and the retention tab is moved aside to release the striker.

Abstract: A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.

Abstract: A time-of-use activated syringe assembly includes a syringe barrel defining a chamber, a plunger rod having a forward attachment end located within the chamber of the barrel, and a stopper located within the chamber of the barrel and including a rearward end adapted to receive the plunger rod. The stopper includes a first perimetrical skirt extending around an outer circumference thereof and extending toward a front end of the stopper. An activation mechanism is associated with at least one of the stopper and the plunger rod, and the plunger rod is configured for transition between a pre-loaded position in which the activation mechanism is unactivated and a loaded position in which the activation mechanism is activated. Upon activation, the activation mechanism applies a radial force to the first perimetrical skirt causing the skirt to seal against an inner wall of the syringe barrel.

Abstract: The present disclosure relates to a drive mechanism for an injection device. The mechanism includes an inner body fixable inside a housing of the injection device and including an elongated shaft extending in an axial direction. The shaft includes an outer thread and a blocking structure on an outer circumference. A tubular-shaped display member has an inner thread engaged with the outer thread of the inner body. A dose member is axially displaceable relative to the inner body or the display member between a dose setting position and a dose dispensing position. A blocking ring is axially engageable with the dose member, rotationally fixed to the display member and includes a blocking element to axially engage with the blocking structure for blocking an axial displacement of the dose member from the dose setting position towards the dose dispensing position.

Abstract: A drug delivery system comprises an indicator element and a sensor system. The indicator element is arranged to rotate relative to a reference component and corresponding to a reference axis and comprises a plurality of dipole magnets. The sensor system comprises a plurality of magnetometers arranged non-rotational relative to the reference component and adapted to determine continuous magnetic field values from the plurality of dipole magnets, as well as processor means configured to determine on the basis of measured values from the plurality of magnetometers a rotational position and/or a rotational movement of the indicator element.

Abstract: A syringe including a barrel, a plunger moveably arranged within the barrel and a plunger rod for driving the plunger, and an engagement member arranged at the barrel to engage with a grooved surface on the plunger rod. This will create feedback given to a user as the plunger rod is moved relative to the barrel for driving the plunger within the barrel. The barrel and the engagement member are arranged relative to each other such that the engagement member, due to the engagement with the grooved surface of the plunger rod, will move solely in a direction generally perpendicular to a longitudinal direction of the plunger rod as the plunger rod is moved relative to the barrel.

Abstract: A spring release mechanism for a drug delivery includes a fusible member to restrain a spring in a charged state. A heating element is utilized to selectively heat and sever the fusible member. When the fusible member is severed, the spring is allowed to discharge and drive the drug delivery device components operably coupled thereto.

Abstract: A server having stored thereon information associated with an identified portable medical device. The server is configured to receive a position and a time point of a client device, and configured to use the position and the time point to retrieve position-specific data for the time point. The position-specific data is used to determine whether the portable medical device should be serviced or replaced.

Abstract: Devices and methods are disclosed for protecting individuals from the sharp ends of medical objects following use on a patient. Such sharp objects include hypodermic needles, scalpel blades, cannulae, trocars, and the like. The protective cover is designed to surround and sequester the sharp in a shell that is will not permit further puncture or cutting with the sharp. In an embodiment, the protective cover also absorbs any fluids on or in the used sharp and prevents any fluids from escaping the protective cover. The devices are configured to be integral to procedure trays or kits such that space and discarded materials are minimized along with the potential for injuring someone with a used, contaminated medical sharp.

Abstract: A port-a-cath needle adapted for determining the position of the needle prior to dispensing medical treatments is disclosed. Disclosed embodiments of the port-a-cath needle comprises a cannula, a hollow needle, and an inflatable balloon. The balloon is disposed at the distal end of the port-a-cath needle such that when the needle is inserted into a patient, the balloon may be inflated and the resistance pressure used to determine if the needle is inserted into the port chamber or a port-a-cath device or is surrounded by soft tissue. In certain embodiments, the balloon may be maintained in the inflated configuration in order to help retain the port-a-cath needle within the port chamber while treatment is delivered to the patient.

Abstract: Methods of protecting muscle tissue from heterotopic ossification employ targeted deliveries of a neuromuscular inhibitor. A method of protecting muscle tissue from heterotopic ossification includes identifying a volume of muscle tissue that is susceptible to heterotopic ossification. A first aliquot of a therapeutic dose of a neuromuscular inhibitor is delivered at a first delivery site within the volume of muscle tissue. A second aliquot of the therapeutic dose is delivered at a second delivery site within the volume of muscle tissue. The first and second delivery sites are separated by a distance to distribute the therapeutic dose within the targeted volume of muscle tissue.

Abstract: Disclosed is a puncture depth controlling and needle hiding device and a usage method thereof. The puncture depth controlling and needle hiding device comprises a housing and an inner sleeve. The inner sleeve is positioned in the housing and is rotatable. Correspondingly matched limiting structures are provided on an inner wall of the housing and an outer wall of the inner sleeve. A spring is provided between the housing and the inner sleeve to push the proximal ends of the housing and the inner sleeve to be separated and keep the inner sleeve at an initial axial position with respect to the housing. By means of the invention, the medicinal liquid injection operation is simplified, and the need insertion depth is accurate. A needle hiding structure reduces the risk of accidental stab.

Abstract: A substance delivery module (4) and apparatus (2) for delivering a substance in aerosol form are disclosed. The substance delivery module (4) comprises a substance container (90), a piston (62) and an actuator (100) configured to engage the substance container (90) and urge the substance container (90) onto the piston (62), so dispensing the substance into the through passage (102) of the piston. The actuator (100) and substance container (90) are mounted in the substance delivery module (4) for relative motion, such relative motion bringing the actuator (100) into engagement with the substance container (90). The substance delivery module (4) may be assembled with an aerosol generator (10) and an aerosol delivery conduit (14) to form an apparatus (2) for delivering a substance in aerosol form. The apparatus (2) may further comprise a control module (6).

Abstract: A discharging device for a pharmaceutical liquid, dispenser including a housing, an applicator tip with a discharge opening and a protective cap. A locking tooth is provided on the protective cap and a counter tooth is provided on the applicator tip. The at least one locking tooth passes over the counter tooth when the protective cap is rotated relative to the applicator tip in a first direction, and the locking tooth and the counter tooth prevent rotation in a direction opposite the first direction. The protective cap and the applicator tip are adapted to each other such that the discharge opening contacts a lid region of the protective cap after the locking tooth has passed over the counter tooth, and the discharge opening can be closed in a sealed manner by the protective cap. The protective cap is deformable to disengage the locking tooth and the counter tooth.

Abstract: A compact wearable modular multifunctional inhalation device of the present invention. In the illustrative embodiment, the device includes a housing with at least one port; a removable cartridge module adapted to seat within the housing, the cartridge including: a source of inhalant mounted within the cartridge for providing inhalant into the port and a heating element mounted within the cartridge for heating the inhalant; a removable modular electronic circuit adapted to seat within the housing to provide electrical current to the heating element; and a mechanism coupled to the housing for wearing the device. The electronic circuit may include a processor and memory. A removable modular electronic display is adapted to seat within the housing and connect electrically with the circuit. Software is stored in the memory for execution by the processor for activating the heating element. The software includes code for monitoring the status of the inhalant and/or the source of electrical potential.

Abstract: A dry powder medicament inhaler for metering an inhalation of dry powdered medicament may include at least one inlet and at least one outlet, wherein a communication between said inlet and outlet at least includes a mixing and deaggregation chamber and at least two dosage communications between the inlet and the chamber. The inhaler may also include a dosage mechanism for arranging at least one dose of a medicament between the inlet and the chamber, such that said at least one dose may be delivered upon inhalation at said outlet through said communications. The inhaler may further include a locking mechanism, wherein on moving the dosage mechanism from a dose collecting position to a dose administering position the locking mechanism may be moved from an unlocked to a locked position preventing the metering of any further doses prior to resetting of the locking mechanism. Instead of a locking mechanism, the inhaler may include a dosage indicator or a counterweight mechanism.

Abstract: A nasal applicator for nasally applying medicinal active ingredients, comprising a dispensing pin which is introduced into a nostril, a active ingredient store arranged in an applicator housing, and a dispensing metering device. A transmitting device is designed to be engageable and disengageable between an actuation button and the dispensing metering device such that when the transmitting device is disengaged, the actuation button is moved in the open passage without a transmission to the dispensing metering device. A movement sensor is provided for detecting movements of the operating button, and a coupling switch is provided for engaging the transmitting device depending on a signal of the movement sensor. To generate a consistent spray pattern, the dispensing metering device comprises a pretensioning mechanism which is tensioned or released to actuate a metering conveyor with a defined pretensioning force, wherein the engaged transmitting device can tension or release the pretensioning mechanism.

Abstract: The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, in need thereof, receiving breathing gas from a high frequency ventilator using at least enhanced therapeutic gas (e.g., nitric oxide, NO, etc.) flow measurement. At least some of these enhanced therapeutic gas flow measurements can be used to address some surprising phenomenon that may, at times, occur when wild stream blending therapeutic gas into breathing gas a patient receives from a breathing circuit affiliated with a high frequency ventilator. Utilizing at least some of these enhanced therapeutic gas flow measurements the dose of therapeutic gas wild stream blended into breathing gas that the patient receives can at least be more accurate and/or under delivery of therapeutic gas into the breathing gas can be avoided and/or reduced.

Abstract: An interface for positive pressure therapy includes a mask assembly, a headgear assembly and a connection port assembly. The mask assembly comprises a seal member that has an upper portion movably connected to an integrated lower portion, wherein the upper portion rolls during hinging movement of the upper portion relative to the lower portion. The headgear assembly allows connection to the mask assembly in a direction substantially normal to a direction of strap tension. The connection port assembly includes a swivel elbow with a valve member that controls flow through a port that opens toward the user.

Abstract: An apparatus for respirating a patient has a gas circulation device for circulating a gas in one direction in a line system, a pressure varying device suitable for varying a pressure of the gas in the line system in accordance with the desired respirating the pattern, a measurement sensor cooperative with the gas in the line system so as to measure a flow rate and composition of the gas, an absorber device suitable for withdrawing carbon dioxide as exhaled by the patient, a bypass line having a closing device suitable for completely or partially leading the respiratory gas outside of the line system, and a circulation blower cooperative with the line system so as to provide a continuous flow of gas in one direction through the line system.

Abstract: A mechanical ventilator (10) is connected with a ventilated patient (12) to provide ventilation in accordance with ventilator settings of the mechanical ventilator. Physiological values (variables) are acquired for the ventilated patient using physiological sensors (32). A ventilated patient cardiopulmonary (CP) model (40) is fitted to the acquired physiological variables values to generate a fitted ventilated patient CP model by fine-tuning its parameters (50). Updated ventilator settings are determined by adjusting model ventilator settings of the fitted ventilated patient CP model to minimize a cost function (60). The updated ventilator settings may be displayed on a display component (22) as recommended ventilator settings for the ventilated patient, or the ventilator settings of the mechanical ventilator may be automatically changed to the updated ventilator settings so as to automatically control the mechanical ventilator.

Abstract: Various improvements are provided to breathing training, monitoring and/or assistance devices. A portable device is provided which optionally includes a gas canister, a feedback system for implementing pressure control, and a visual output for indicating adherence to a breathing exercise to the user. The pressure control may provide regulation of different pressures for inhalation and exhalation.

Abstract: In one aspect of the present disclosure, an airway device is disclosed that includes a bite block and a depressor section. The bite block has proximal and distal ends and is configured and dimensioned for positioning between a patient's upper and lower teeth. The depressor section also has proximal and distal ends and extends distally from the bite block. The depressor section includes upper and lower members that are separated by a web as well as a stop. The lower member includes a first portion having a generally linear configuration and a second portion having an arcuate configuration, and the stop depends transversely from the first portion of the lower member.

Abstract: A mask assembly for use as part of an apparatus for supplying a flow of respiratory gases to a user is disclosed. The mask assembly includes a mask body having an inlet through which said flow of respiratory gases are provided to the interior of said mask body. A mask seal assembly comprising a seal of flexible material and a clip of rigid material is attached to the body. The seal has a first side and a second side. The first side of the seal is shaped to approximately match the contours of a user's face and in use substantially seal against a user's face. The second side is attached to the clip. The clip provides an interface extending substantially the full perimeter or periphery of the mask seal assembly for releasably attaching the mask seal assembly to the mask body. The clip comprises a bridging portion spanning outwards from the perimeter or periphery of the mask body to space at least a portion of the second side of the seal outwards from the perimeter or periphery of the mask body.

Abstract: A mask assembly for delivering breathable gas to a patient may include a patient interface structured to engage the patient's face and provide a seal, a headgear arrangement to support the patient interface in a desired position on the patient's face, and an audio unit provided to at least one of the patient interface and the headgear arrangement. The audio unit may be operable to selectively generate at least one sound.

Abstract: A reusable respirator including a mask adapted for covering and conforming to the face around the nose and a mouth of a user, a strap configured to secure the mask to a face of the user, and a filter component. All components of the respirator are capable of being cleaned, disinfected and sterilized at temperatures in excess of 50° C. An outer surface of the mask is substantially smooth and wettable for easily disinfecting and is shaped with a pair of outer shield portions for housing particulate air filters. The outer shield portions each include a closeable vent through the outer surface that is adapted to provide a user seal check and direct air flow through the outer surface for filtering by the respective particulate air filter, which is adapted to filter at least 95% of airborne particles.

Abstract: A gases delivery system for medical use is disclosed that has a container configured to house a metal-organic framework material within at least one section of the container. An activation mechanism may be associated with the container. The metal-organic framework material may contain one or more substances such that the one or more substances may be released from the metal-organic framework material when energy is applied to the container via the activation mechanism. The activation mechanism may be a heating mechanism. One or more containers housing metal-organic framework materials may be used in a gases recirculation system.

Abstract: Provided herein is a needle device for a nerve block, which includes a gripping part having a longitudinal passage through which a liquid fluid flows, said liquid fluid also flowing through the inside of a needle aligned with the longitudinal passage. The device also includes a nerve stimulator through which electricity is transmitted to the needle. The gripping part includes a radial duct that intersects tangentially with the longitudinal passage, the radial duct having two opposite female couplings into either of which the nerve stimulator can be inserted, depending on whether the user is left-handed or right-handed.

Abstract: Methods for provoking a physiological response in a subject comprising: receiving from sensors an orientation of an HMD of the subject and a parameter indicative of a physiological state of the subject, determining a video signal representing an avatar of the subject in a virtual reality scenario to be displayed on the head mounted display taking into account the orientation of the head mounted display, wherein the video signal includes an indication of a physiological state of the avatar, and sending the video signal to the head mounted display for visualization, optionally accompanied by a suitable audio signal. During a first period, the indication of the physiological state of the avatar substantially corresponds to the measured physiological state, and during a second period the indication of the physiological state of the avatar does not correspond to the measured physiological state. Related computer program and computing systems are also disclosed.

Abstract: Disclosed is a weighted material that is configured to effectuate deep pressure therapy to a person when a piece of the weighted material is used as a blanket over the person's body. A length of layered yarn is interlooped to form the piece of weighted material. The layered yarn includes an outer tube extending longitudinally from a first end to a second end. The outer tube defines a conduit extending longitudinally therethrough from the first end to the second end. A plurality of inner layers of material are disposed within the conduit and extend longitudinally from the first end to the second end. The interlooped length of yarn, by itself, is configured and sufficiently weighted to effectuate deep pressure therapy to a person when the blanket lies over the person's body. Various other systems and methods are also disclosed.

Abstract: Attachment of tubes of various constructions for use in a microcatheter, including joining to a multifilar helix. Methods of uses and construction with concentric tubes axially displaceable over one another to control navigability and/or positioning properties of a microcatheter.

Abstract: Disclosed herein are segmented MRI-compatible interventional devices, such as catheters and guidewires, that provide desired mechanical properties while avoiding undesired interactions with MRI fields. Disclosed devices can include helical wires with insulated breaks at intervals along each wire so that the insulated wire segments are individually short enough to avoid substantial resonance and heat being generated in the wires due to an applied MRI field. The segmented wires can be organized into a braided/woven tubular configuration or a non-braided intercalated/parallel tubular configuration that provides the desired mechanical properties similar to conventional metallic braided catheters. The helical wire segments can be insulated such that the wires do not touch each other at points where they cross over each other.

Abstract: A telescoping catheter is provided such as for distal neurovascular aspiration or access. The catheter includes an elongate, flexible tubular body, having a proximal section with at least one lumen and a distal section which is axially movably positioned within the lumen. A control is provided for advancing the distal section from a first, proximally retracted position within the proximal section to a second extended position, extending distally beyond the proximal section. The distal end of at least one of the proximal and distal sections may be provided with at least one active feature, such as at least one movable jaw or rotatable agitator, to assist in the capture of vascular obstruction. The jaw may be operable in response to application of pulsatile negative pressure through the catheter.

Abstract: A medical tube including a flexible tube-shaped main body, a hub connected to the proximal portion of the tube-shaped main body, and a strain relief member supported at a distal portion of the hub. The strain relief member surrounds a predetermined portion of the proximal portion of the tube-shaped main body. The tube-shaped main body includes a flexible portion which possesses increased flexibility for bending. The flexible portion includes at least one groove extending in a circumferential direction in the outer circumferential surface of the tube-shaped main body over a predetermined range in an axial direction of the tube-shaped main body from a position distal of the distal-most end of the strain relief member to a position proximal of the distal-most end of the strain relief member.

Abstract: This document relates to catheter-based therapeutic apparatus and methods for directing therapy within the body of a subject. This document also encompasses a control handle comprising a steering assembly and a delivery assembly suitable for use in conjunction with the catheter-based therapeutic apparatus to provide steering and fine positional control of the catheter tip.

Abstract: Steerable catheters include cam and follower mechanisms that provide independent control of catheter flex magnitude and catheter flex direction to provide improved steerability of an attached catheter. In certain embodiments, the steerable catheter assemblies include two or more pull wires that flex the catheter, and a control handle coupled to the catheter having a direction control and a magnitude control, both of which are operably coupled to the two or more pull wires by the cam and follower mechanism. In embodiments disclosed herein, the cam and follower system can be modified to achieve particular catheter control.

Abstract: A system for locating the tip of a catheter inside a human body is provided. The system includes a sound sensor for sensing the magnitude wave form generated by sound pressure as a PICC is progressed toward a heart of a patient. The systems also includes a monitor operably coupled to the sensor for measuring the magnitude of wave form generated by the sound sensor.