Abstract: Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.

Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.

Abstract: The present disclosure relates to combination therapies for the treatment of pathological conditions, such as cancer. In particular, the present disclosure relates to combination therapies comprising treatment with an Antibody Drug Conjugate (ADC), a secondary agent, and optionally an anti-CD20 agent. The Antibody Drug Conjugates target CD19 or CD22 and are disclosed for the treatment of cancers. Methods for identifying an individual as suitable for treatment by selecting patient if he/she is or has been treated with an anti-CD20 agent such as rituximab are disclosed. Optionally, the ADC is administered in combination with a further agent, e.g. a chemotherapeutic agent.

Abstract: Conjugates of an antibody that binds to CD25 with PBD dimers.

Abstract: Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.

Abstract: Novel adeno-associated virus (AAV) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. Certain of the vectors are able to cross tightly controlled biological junctions, such as the blood-brain barrier, which open up additional novel uses and target organs for the vectors, providing for additional methods of gene therapy and drug delivery.

Abstract: Methods are provided for treating a patient with viral-based gene therapy that promote persistent transgene expression. The methods include administering to the patient an inhibitor of the interleukin-6 (IL6) signaling pathway or the NCOR2/SMRT histone deacetylation pathway, and a viral-based gene therapy vector. Methods are also provided for assigning viral-based gene therapy to a patient that include determining whether the patient has a genotype sensitizing the patient to persistent infection by a viral-based gene therapy vector by evaluating whether the patient has a mutation in the SMRT/NCOR2 gene associated with reduced SMRT/NCOR2 protein function or in the interleukin-6 receptor (IL-6R) gene associated with reduced IL-6R function. If the patient has either a mutation in the SMRT/NCOR2 gene associated with reduced SMRT/NCOR2 protein function or a mutation in the IL-6R gene associated with reduced IL-6R function, a viral-based gene therapy vector is assigned to the patient.

Abstract: Described herein are compositions and methods for treating diseases and disorders of the brain using a non-viral nanoparticle delivery of CRISPR. Disclosed herein are compositions comprising CRISPR-Gold compositions comprising DNA oligonucleotides, RNA-directed nucleases and guide RNAs. The methods include modulating expression of a gene in a cell using said compositions, inducing site-specific DNA cleavage in a cell, and treating a subject having fragile X syndrome caused by increased metabotropic glutamate receptor 5 signaling using the compositions disclosed herein.

Abstract: A hybrid molecule comprising at least one contrast agent, and at least one substrate of a self-labeling enzyme, and optionally a fluorescent moiety is provided. Compositions comprising same and use thereof, are also provided.

Abstract: Disclosed herein are urushiol-containing epicutaneous patches comprising a support material and a urushiol-containing film on a surface of the support material. A surface of the support material is coated with the urushiol-containing film. Also described herein are test panels comprising urushiol-containing epicutaneous patches of varying urushiol content. The test panels can be employed in methods to assess subject sensitivity to urushiol, to determine a dose-response relationship to varying doses of urushiol, and to assess efficacy of treatments to prevent or inhibit urushiol-induced contact dermatitis in a subject.

Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.

Abstract: The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer.

Abstract: Among the various aspects of the present disclosure is the provision of compositions of imaging agents and methods for use in detecting, monitoring, and evaluating CCR2 associated diseases, disorders, and conditions.

Abstract: The present invention provides methods, compounds, and compositions useful for determining the biodistribution of an activated binding polypeptide in a mammalian subject. The present invention also provides methods for identifying mammalian subjects suitable for treatment with an activatable binding polypeptide.

Abstract: Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.

Abstract: An assembly for redirecting light emitted by an end-emitting optical fiber into an inner lumen of a body is provided. According to one implementation, the body includes one or more surfaces disposed on or in the body onto which the light is configured to impinge when the end emitting optical fiber is activated, the one or more surfaces being configured to alter the trajectory of the light so that the light is directed to impinge on a light reflector of a cap removably attached to the body, the light reflector of the cap being configured to redirect the light distally into the inner lumen of the body.

Abstract: Systems and methods for multiple band visible light disinfection are disclosed. In some examples, a disinfecting light is generated by combining two different disinfecting wavelength ranges of light. A lighting device may comprise a first light source that generates light in a Soret band. The lighting device may further comprise a second light source that generates light in a Q band. The light in the Soret band and the light in the Q band may be combined to generate disinfecting light.

Abstract: A chemical disinfection process for vehicles using chlorine dioxide and titanium dioxide with calculated re-treatment formulas and schedules based on bacterial infestation data. Systems and methods that include client devices and servers that monitor and control a chemical disinfection process. The system generates a surety arrangement that facilitates re-treatment and electronic notification alerts to chemical solution vendors, dealers and vehicle owners.

Abstract: A device for disinfecting pipelines, containers and structures using disinfectants and/or electromagnetic radiation. Water is drained from pipes, containers and structures through which water flows. They are then preliminarily cleaned, and disinfectants are dispensed as a mist via spray heads provided on a spray chain that is moved through the pipe, container or structure. The spray chain can have CO2 nozzles and associated CO2 supply equipment. Alternatively, or in addition, the drained pipes, containers and structures are disinfected using electromagnetic radiation emitted by means of radiation sources.

Abstract: A method for decontaminating a tube includes positioning an antenna at least partially within the tube. The tube is positioned at least partially within a living body. The method also includes decontaminating the tube by causing the antenna to emit electromagnetic waves having a frequency from about 10 GHz to about 100 GHz for a time duration that is less than or equal to 60 seconds. The electromagnetic waves cause a temperature of the living body proximate to the tube to increase from about 0.1° C. to about 3° C. so as to not substantially damage the living body.

Abstract: An apparatus for sanitizing is provided. The apparatus includes a housing having a reservoir for retaining sanitizing fluid. The apparatus also includes a holder disposed beneath the housing. The apparatus further includes an applicator pad received by the holder and adapted to be in selective fluid communication with the reservoir. The applicator pad includes a dome-shaped portion having a substantially hemi-spherical shape configured to extend into an interior region of a bell of a stethoscope head when the bell is placed over the dome-shaped portion.

Abstract: An apparatus for sterilizing load in a sterilization chamber according to specific characteristics of the load without direct measurement of the load conditions. The apparatus preferably admits sterilant gas into the sterilization chamber under vacuum; during admission of the sterilant gas, the apparatus monitors a sterilant condensation related parameter or data in the sterilization chamber. The apparatus detects the occurrence of condensation and determining a value of the condensation related parameter while detecting condensation and, selects a sterilization cycle among a plurality of predetermined sterilization cycles according to the condensation related data. The apparatus that performs the selected sterilization cycle for sterilizing the load. The condensation related data may be the sterilant dew point, a degree of condensation, or an amount of condensation which may be determined in monitoring the chamber pressure during sterilant gas admission.

Abstract: A portable sanitizing apparatus, such as a case, includes a first case portion arranged to receive an object to be sanitized, and a second case portion connected to the first case portion and including at least one UV light source configured to emit UV electromagnetic radiation. The second case portion includes an expansion member having a collapsed configuration and an expanded configuration. When the expansion member is in the expanded configuration, a distance between the second case portion and the first case portion is increased compared to when the expansion member is in the collapsed configuration, thereby increasing a distance from the at least one UV light source to the object to be sanitized.

Abstract: Sterilization containers, components, and methods thereof. A locking mechanism is used to secure and release a filter assembly on a sterilization container includes two opposing buttons that, when compressed toward each other, unlock the locking mechanism and, when released, secure the locking mechanism.

Abstract: An ozonizing device comprises a box-shaped body which encloses therein ventilation device, a discharge ozone generator, an ozone-catalysing UV-C lamp and an additional ozone generator. The box-shaped body comprises a partition wall intended to define two distinct chambers in said box-shaped body: a first chamber in which the ventilation device, the discharge ozone generator and the ozone-catalysing UV-C lamp are housed, and a second chamber in which the further ozone generator is housed which is interfaced with air distribution device associated with a diffuser tube for the diffusion of an ozone-enriched air flow. The ozonizing device further comprises a control unit configured so as to selectively activate, alone or in combination, each of the discharge ozone generator, ozone-catalysing UV-C lamp and the additional ozone generator.

Abstract: A microfluidic delivery device and method of dispensing a fluid composition from a microfluidic die are provided. The method includes generating air flow from a fan; directing a first portion of the air flow through a first air outlet in a housing; directing a second portion of the air flow through a second air outlet in the housing; jetting a fluid composition from a microfluidic die through a fluid orifice in the housing; directing the second portion of air flow adjacent to the microfluidic die and out the fluid outlet, wherein the first portion of the air flow directs the fluid composition jetted out of the fluid outlet into the air.

Abstract: A photocatalytic air treatment system, including apparatuses and methods, for killing and/or mineralizing bacteria, viruses, mold, fungi, spores, mycotoxins, allergens, and other similar microorganisms or agents, and for oxidizing volatile organic compounds (VOCs). The system comprises one or more reactor beds configured in one or more stages with each reactor bed including a plurality of photocatalyst coated media substantially surrounding a plurality of sheathed ultraviolet light sources that may be arranged in a plurality of configurations. Adjacent ultraviolet light sources are positioned so as to create killing zones of photocatalyst coated media therebetween that are irradiated with ultraviolet light from multiple sources and in which an increased number of hydroxyl radicals are present. The photocatalyst generally comprises titanium dioxide, but may include one or more enhancers. The media is formed from or is coated with a material that induces the photocatalyst to form a nano-particle structure.

Abstract: A wound dressing including a hydropolymer matrix crosslinked with genipin and a plurality of thymol nanoparticles loaded into the hydropolymer matrix. The plurality of thymol nanoparticles has a concentration between 0.01 wt. % and 1 wt. % of dry weight of the wound dressing. The hydropolymer matrix includes gelatin, chitosan, polyvinylpyrrolidone (PVP), and carboxymethyl cellulose (CMC).

Abstract: A wound covering is provided that comprises a substrate and vitamin D, or analogues or metabolites thereof, embedded in the substrate. Methods of making a wound covering are also provided and include the steps of providing a solution that includes a polymer; adding vitamin D, or analogues or metabolites thereof, to the solution to form a mixture; and forming one or more fibers from the mixture that are then embedded with the vitamin D, or analogues or metabolites thereof. Methods of treating a subject are further provided and include the step of applying a wound covering including one or more fibers embedded with vitamin D, or analogues or metabolites thereof, to a site on a subject.

Abstract: A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female.

Abstract: A hemostatic composition of matter includes a coherent blend of collagen fibrils combined with starch particles as a fluffy mass with hemostatic properties better than collagen fibrils alone or starch particles alone, the composition exhibiting a level of coherence wherein the composition can be lifted, without crushing fibrils, without loss of more than 5% of 10% of a total weight of starch particles from the composition. Sheets with less than 10% by weight of additional binder are also disclosed.

Abstract: A coated implant includes a coating comprising a doped hydroxyapatite portion and an undoped hydroxyapatite portion. The coated implant can be formed by treating a hydroxyapatite coating with a solution comprising a dopant metal.

Abstract: Silicone polyurea block copolymers are prepared by copolymerizing: (a) a diamine composition that includes a polyethylene glycol diamine, and optionally, a dipiperidyl alkane; (b) a monofunctional silicone isocyanate; and (c) a diisocyanate. Compositions useful as passivating coatings comprising the block copolymer are also provided, and substrates coated with the compositions. Methods of preparing and using the compositions are also described.

Abstract: A biological product for clinical xenotransplantation into a human and a method of preparing biological product for clinical xenotransplantation into a human involving producing a non-wild type, biologically engineered swine having a biologically engineered genome such that the swine does not express one or more extracellular surface glycan epitopes, is free of certain pathogens, is reared according to a bioburden-reducing procedure in a closed designated pathogen free herd, wherein the biological product is harvested following the swine being euthanized and the product is aseptically removed from the swine, the biological product is processed involving sterilization and storing the product in a sterile container, and the product does not contain one or more extracellular surface glycans, is free of certain designated pathogens, is biologically active and comprises live cells and tissues capable of vascularizing after xenotransplantation.

Abstract: Methods of harvesting cancellous bone and bone marrow include extracting loosened cancellous bone and bone marrow—including a liquid component thereof—to a collection container that has a first cup and a suction port to which a suction source is connected. After extraction, the suction source is disconnected and a lid of the collection container is removed and replaced with a lid having a plunger with a press head that is configured to filter the extracted liquid by depressing the plunger toward a bottom of the first cup. The filtered liquid is poured through a suction port into a second cup while depressing the plunger, thereby separating the liquid from a semi-solid mass of cancellous bone that remains. The bone is extracted through a cortical opening in the femur, tibia, or calcaneus, or from an intermedullary canal that is preferably formed by reaming of the tibia using an orthopedic reamer.

Abstract: It is a biomaterial developed from decellularized animal bone tissue and coated with a bone extracellular matrix in the form of a gel, which is capable of conferring efficient mechanical and biological support, and which can also be enriched with cells, nanocomposites or drugs, when used as a bone graft, bioreactor, or vehicle in treatments, research and development of other biomaterials; That is, it was developed from decellularized, lyophilized, porous and rigid, manipulable, safe and non-immunogenic bone material, coated and enriched with stimulating substances specific to bone tissue, presented/used in particulate or block form, thus possessing ability to promote the development of in vitro mature or progenitor cell lines when used as a bioreactor, and demonstrates a high integration capacity and a faster rate of fracture healing and filling of bone defects when used as an in vivo graft; The biomaterial also allows the promotion of cellular development, from the maintenance of the integrity of the organic

Abstract: Provided herein are, inter alia, therapeutic formulations containing active agents, such as bioactive cell populations, and methods of making and using the same.

Abstract: The present provides a biomaterial for repairing biological tissues, the biomaterial comprising: a water-soluble polymer having a reactive functional group A; and a cell having tissue-regenerating capacity and having, on the surface thereof, a reactive functional group B that can covalently bind to the reactive functional group A, wherein the biomaterial presents a hydrogel state when the reactive functional group A covalently binds to the reactive functional group B. Thus, the present invention can provide a biomaterial for repairing biological tissues that can exert excellent effect in repairing biological tissues by utilizing a hydrogel encapsulating cells having tissue-regenerating capacity.

Abstract: The present invention relates to a hydrogel useful to promote neurotization, osteogenesis and angiogenesis.

Abstract: Methods of regenerating vital tooth tissue in situ after endodontic therapy include introducing a hydrogel scaffold into a root canal of a tooth in a patient after native pulp has been removed from the root canal. The hydrogel scaffold may comprise a sponge scaffold, and can be acellular. The hydrogel scaffold can contain chemotactic, angiogenic, neurogenic, and/or immunomodulatory biofactors that cause infiltration of endogenous cells from the patient into the root canal. Alternatively, such biofactors/drugs can be administered to the patient separately from the hydrogel scaffold. The hydrogel scaffold can fill the periapical space of an abscessed root.

Abstract: This is a water disintegrable, flushable catheter that will dissolve or biodegrade in water. It is coated with a hydrophilic coating and will achieve lubricity values typical of a hydrophilic catheter. The catheter may be formed of a bi-layer tube that has a biodegradable outer layer such as polylactic acid and a purely water disintegrable inner layer, e.g., polyvinyl alcohol (PVOH). The outer layer will support the hydrophilic coating even when it's wetted and thus acts as a stable primer layer for hydrophilic style coatings. The outer layer bonds well to the water disintegrable inner layer but also allows a hydrophilic coating to be applied on top. The outer layer acts as a temporary water barrier. This water barrier allows the hydrophilic coating to be hydrated prior to use but prevents water molecules from attacking the PVOH inner layer.

Abstract: A flexible tube for an endoscope has a flexible tube substrate that is flexible and tubular and a resin layer (A) covering the flexible tube substrate. The resin layer (A) includes a thermoplastic resin (a) including at least one of a polyatnide resin, a polyurethane resin, a polyester resin, a polystyrene resin, or an acrylic resin and having a tensile strength at 10% elongation of 10 Pa or more and a hindered amine compound (b) having a molecular weight of 500 or more. Also provided are an endoscopic medical device including the flexible tube for an endoscope and a resin composition suitable for forming the resin layer of the flexible tube for an endoscope.

Abstract: A process for making lipid-coated substrates including the steps of a. providing a lipid solution (A) of phospholipids in a water miscible organic solvent at a phospholipid concentration between 25 and 450 mg/ml; b. provide an aqueous solution (B) having pH between 4 and 8; c. agitate the aqueous solution (B) and dispense the lipid solution (A) into the aqueous solution (B) to prepare an aqueous dispersion including lipid vesicles (C) having a number average size between 80 and 120 nm (measured according to dynamic light scattering) at a phospholipid concentration between 0.05 mg/ml and 2 mg/ml; and d. applying the aqueous dispersion (C) to a substrate and formation of a lipid-based coating; wherein aqueous dispersion (C) contains at least 95 wt. % water. Medical devices including a lipid-based coating, for example contact lenses and catheters.

Abstract: A self-expandable stent has sufficient radial force, has good bending properties, and recovers the shape for the diameter thereof to return from a diameter in a contracted state to a diameter before contraction around a body temperature (37° C.). The self-expandable stent includes a crosslinked polymer containing a constitutional unit (A) obtained from a monomer that constitutes a rigid biodegradable polymer when homopolymerized and a constitutional unit (B) obtained from a crosslinking agent, in which a content of the constitutional unit (B) is 15% by weight to 35% by weight with respect to a content of the constitutional unit (A).

Abstract: Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).

Abstract: Medical grade yarns, medical devices constructed of such yarns, and methods for making such yarns and devices are described. Polyester drawn fibers, and more particularly high strength and high tenacity micro polyester fibers for use in medical devices, and methods of preparing the same are provided.

Abstract: An image coding method includes: performing context arithmetic coding to consecutively code (i) first information indicating whether or not to perform sample adaptive offset (SAO) processing for a first region of an image and (ii) second information indicating whether or not to use, in the SAO processing for the first region, information on SAO processing for a region other than the first region, the context arithmetic coding being arithmetic coding using a variable probability, the SAO processing being offset processing on a pixel value; and performing bypass arithmetic coding to code other information which is information on the SAO processing for the first region and different from the first information or the second information, after the first information and the second information are coded, the bypass arithmetic coding being arithmetic coding using a fixed probability.

Abstract: A single breast pump device (1) is adapted to enable realization of at least two batches (A, B) of breast milk as a direct result of a single pumping session to be performed on at least one user's breast, which batches (A, B) are different as far as the value of at least one quality parameter of the breast milk is concerned. The single breast pump device (1) comprises a detection unit (50) for performing real-time detection of the at least one quality parameter in a flow of breast milk and outputting a detection signal representing an actual value of the at least one quality parameter, and further comprises a controller (70) for receiving the detection signal from the detection unit (50) and using the signal in a process of determining an appropriate setting of the single breast pump device (1) as far as the choice of a destination position of the milk is concerned. A double breast pump device (2) is also disclosed.

Abstract: A breast shield arrangement (300) for a breast pump comprises a first sealing portion (310), a port (320) and an intermediate portion (330) coupled between the first sealing portion (310) and the port (320). The intermediate portion (330) comprises a circumferentially extending wall defining a first volume (V1) which is adapted to receive a part of a breast, a first end (331), a curved portion (332) and a second end (333). The curved portion (332) comprises a second sealing portion (332c) which is adapted to at least partially seal the curved portion (332) against the nipple (310), the areola (320) or the breast (200) when a vacuum is applied at the port (320) creating a second volume (V2) between the first sealing portion (310, 332c) of the breast (200). The curved portion (332) at the second volume is curved outwardly as seen from the first sealing portion (310).

Abstract: A temporary, removable mechanical circulatory support heart-assist device has at least two propellers or impellers. Each propeller or impeller has a number of blades arranged around an axis of rotation. The blades are configured to pump blood. The two propellers or impellers rotate in opposite directions from each other. The device can be configured to be implanted and removed with minimally invasive surgery.