Abstract: An exercise intensity estimation apparatus includes an RS wave calculation unit configured to calculate an RS amplitude from a peak value of an R wave to a peak value of an S wave in an ECG waveform of a target person, a T wave calculation unit configured to calculate an amplitude of a T wave of the ECG waveform, a heart rate calculation unit configured to calculate a heart rate from the ECG waveform, an index calculation unit configured to calculate, as a first index indicating exercise intensity of the target person, the amplitude of the T wave normalized by the RS amplitude, and an index calculation unit configured to calculate, as a second index indicating the exercise intensity of the target person, a value obtained by multiplying the first index by the heart rate.

Abstract: A data processing method for determining a range of motion of an artificial knee joint which connects a femur and a tibia via a medial ligament and a lateral ligament, wherein at least the femur comprises an implant which forms a medial condyle and a lateral condyle, the method comprising the steps of: acquiring the maximum lengths of the lateral ligament and the medial ligament for a particular flexion angle of the knee joint; calculating a first virtual position between the femur and the tibia in which the lateral condyle of the femoral implant touches the tibia and the medial ligament is stretched to its maximum length; calculating a maximum valgus angle of the range of motion from the first virtual position; calculating a second virtual position between the femur and the tibia in which the medial condyle of the femoral implant touches the tibia and the lateral ligament is stretched to its maximum length; and calculating a maximum varus angle of the range of motion from the second virtual position.

Abstract: Disclosed is a health management system combined with a smart bed set. Unlike conventional hospital beds used for medical treatments or medical beds used for examining patients, the system of this disclosure breaks through the limitations that patients have to go to hospitals for physical examination and reduces spaces. This system detects and accumulates physiological data during our sleeping time for a long time and analyzes the physiological data to assist an early discovery of potential diseases, and the analyzed information is provided for the personal health management of individuals or the reference for medical professionals.

Abstract: A method and apparatus for quantifying volume of a deposited skin-print A method of determining a volume of skin-print residue deposited on a substrate is disclosed. The method comprises: performing interferometry on the substrate with skin-print residue deposited thereon to determine raw topography data of the substrate including the skin-print residue. The method also comprises: processing the raw topography data including subtracting topography of the substrate without the skin-print residue from the raw topography data in order to determine skin-print residue topography data. The method further comprises: determining volume of skin-print residue deposited on the substrate from the skin-print residue topography data.

Abstract: A physiological signal monitoring device includes a sensing member and a transmitter connected to the sensing member and including a circuit board that has electrical contacts, and a connecting port, which includes a socket communicated to the circuit board and a plurality of conducting springs. The sensing member is removably inserted into the socket. The conducting springs are electrically connected to the electrical contacts and the sensing member for enabling electric connection therebetween. Each of the conducting springs is frictionally moved by the sensing member during insertion of the sensing member into the socket and removal of the sensing member from the socket.

Abstract: A method for manufacturing an implantable micro-biosensor includes the steps of: a) providing a substrate, b) forming on a first surface of the substrate a first working electrode which at least includes a first sensing section including a first conductive material, c) forming on the first surface of the substrate at least one second working electrode which at least includes a second sensing section disposed proximate to at least one side of the first sensing section, and d) forming a chemical reagent layer which at least covers the first conductive material of the first sensing section and which reacts with the analyte to produce a product.

Abstract: Disclosed in the present invention is an enzyme-free glucose detection chip for detecting blood sugar level of a blood in a neutral environment, including: a substrate; a detection portion, disposed on an end surface of the substrate; a plurality of protrusions, disposed at the detection portion; a conductive layer, disposed on a surface of the substrate having the protrusions; and a plurality of gold nanoparticles, dispersed on surfaces of the protrusions, wherein the characterized in that the conductive layer is made by mixing gold and platinum and the ratio (mol/v) of platinum to gold is 1:2 to 4:1.

Abstract: Methods, systems and devices for providing improved calibration accuracy of continuous and/or in vivo analyte monitoring systems based at least in part on insulin delivery information are provided. Many of the embodiments disclosed herein can determine appropriate conditions for performing a calibration of the analyte sensor in view of the scheduled delivery of insulin or administered insulin amount. One or more other parameters or conditions can also be incorporated to improve calibration accuracy including, for example, the physiological model associated with a patient, meal information, exercise information, activity information, disease information, historical physiological condition information, as well as other types of information. Furthermore, according to some embodiments, calibration of the analyte sensor can be delayed or not performed at all, if appropriate conditions are not met.

Abstract: An implantation device for prompt subcutaneous implantation of a sensor to measure a physiological signal of an analyte in a biofluid of a living body is disclosed. The implantation device includes a housing, an implantation module, a detachable module and a bottom cover. The housing has a bottom opening. The implantation module includes an implanting device and a needle extracting device. The detachable module includes the sensor detachably engaged with the implantation module; and a base configured to mount the sensor thereon. The bottom cover is detachably coupled to the bottom opening so that the housing and the bottom cover together form an accommodating space. The implantation module and the detachable module are accommodated in the accommodating space. The bottom cover has an operating portion configured to bear a force, and a supporting portion is formed on the opposite end of the operating portion.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a waterproof seal disposed above the implantation hole, and an elastic divider disposed in the implantation hole to separate the implantation hole and covering all over a cross-sectional area of the implantation hole.

Abstract: A sensor is provided for measuring a dissolved oxygen concentration in vivo when implanted at a tissue site and in ex vivo applications. The sensor includes an article comprising a sensing medium retained within the implantable article by an oxygen-permeable material. The sensing medium comprises an MR contrast agent for oxygen. The sensor is configured to indicate the dissolved oxygen concentration of a fluid, e.g., in vivo at the tissue site, when subjected to an MR-based method.

Abstract: An electrochemical sensor including a working electrode having an arrangement of pillars defining channels between the pillars. The channels increase confinement of a byproduct produced in an electrochemical reaction used during sensing of an analyte, so as to increase interaction of the byproduct with the working electrode. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

Abstract: Systems, devices, and methods for detecting, measuring and classifying meals for an individual based on analyte measurements. These results and related information can be presented to the individual to show the individual which meals are causing the most severe analyte response. These results can be organized and categorized based on preselected criteria or previous meals and results so as to organize and present the results in a format with reference to glucose as the monitored analyte. Various embodiments disclosed herein relate to methods, systems, and software applications intended to engage an individual by providing direct and timely feedback regarding the individual's meal-related glycemic response.

Abstract: The present invention provides a micro biosensor for reducing a measurement interference when measuring a target analyte in the biofluid, including: a substrate; a first working electrode configured on the surface, and including a first sensing section; a second working electrode configured on the surface, and including a second sensing section which is configured adjacent to at least one side of the first sensing section; and a chemical reagent covered on at least a portion of the first sensing section for reacting with the target analyte to produce a resultant. When the first working electrode is driven by a first working voltage, the first sensing section measures a physiological signal with respect to the target analyte. When the second working electrode is driven by a second working voltage, the second conductive material can directly consume the interferant so as to continuously reduce the measurement inference of the physiological signal.

Abstract: A physiological signal monitoring device includes a base, a biosensor mounted to the base and adapted to measure an analytical substance, and a transmitter. The base includes a flexible base body and a first coupling structure. The first coupling structure is disposed on the bottom plate. The transmitter is removably mounted to the base body, and includes a bottom casing and a second coupling structure. The first and second coupling structures are coupled to each other when the transmitter is mounted to the base body, and are uncoupled from each other by the flexibility of the base body when an external force is applied on a periphery of the base body. The first and second coupling structures are disposed to be distal from a periphery cooperatively defined by the base and the transmitter when the first and second coupling structures are coupled to each other.

Abstract: A physiological signal monitoring device includes a sensing member and a transmitter connected to the sensing member and including a circuit board that has electrical contacts, and a connecting port, which includes a socket communicated to the circuit board and a plurality of steel balls. The sensing member is removably inserted into the socket. The steel balls are electrically connected to the electrical contacts and the sensing member for enabling electric connection therebetween. Each of the steel balls is frictionally rotated by the sensing member during insertion of the sensing member into the socket and removal of the sensing member from the socket.

Abstract: A physiological signal monitoring device includes a base including a base body that has a bottom plate and an opening, a biosensor mounted to the base, and a transmitter removably mounted to the base body. The base further includes a first coupling structure disposed on a top surface of the bottom plate, and the transmitter includes a second coupling structure coupled to the first coupling structure when the transmitter is mounted to the base body. When the first and second coupling structures are coupled to each other, they are disposed to be distal from a periphery cooperatively defined by the base and the transmitter. They are uncoupled from each other when an external force is applied through the opening of the base body to separate the transmitter from the base.

Abstract: A physiological signal monitoring device includes a sensing member and a transmitter connected to the sensing member and including a circuit board that has electrical contacts, and a connecting port, which includes a socket communicated to the circuit board and a plurality of conducting springs disposed at two opposite sides of the socket. The sensing member is removably inserted into the socket. The conducting springs are electrically connected to the electrical contacts and the sensing member for enabling electric connection therebetween. Each of the conducting springs is frictionally rotated by the sensing member during insertion of the sensing member into the socket and removal of the sensing member from the socket.

Abstract: The present invention provides a measuring method for prolonging a usage lifetime of a micro biosensor implanted subcutaneously to measure a physiological signal associated with an analyte. The micro biosensor includes a working electrode and a counter electrode, wherein the counter electrode includes silver and a silver halide having an initial amount. The method includes cyclic steps of: applying a measurement voltage to drive the working electrode to measure the physiological signal, where the silver halide is consumed by a specific amount; stopping applying the measurement voltage; and whenever the physiological parameter is obtained, applying a replenishment voltage to drive the counter electrode, thereby the silver halide of a replenishment amount being replenished to the counter electrode, wherein a guarding value of a sum of the replenishment amount and the initial amount subtracting the consumption amount is controlled within a range of the initial amount plus or minus a specific value.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a containing indentation containing the signal output end, a fixing indentation fixing thereto the sensor and communicating with the containing indentation, a waterproof seal disposed above the implantation hole, an elastic divider disposed in the implantation hole to separate the implantation hole and covering all over a cross-sectional area of the implantation hole, and a blocking element disposed between the implantation hole and the fixing indentation to hold the sensor.

Abstract: An implantable micro-biosensor includes at least one counter electrode, a first working electrode, a chemical reagent layer, and at least one second working electrode. The chemical reagent layer reacts with an analyte to product a product, such that a first sensing section of the first working electrode is driven to perform a measurement action. A second sensing section of the second working electrode is driven to perform an interference-eliminating action to consume interference. The second working electrode cooperates with the counter electrode to permit the counter electrode to be driven to perform a regeneration action to regenerate silver halide.

Abstract: A physiological signal monitoring device includes a biosensor, and a transmitter including a bottom casing, a processing unit and a battery. The bottom casing has a first stepped section, a second stepped section, and a riser section interconnecting the first stepped section and the second stepped section. The processing unit corresponds in position to the first stepped section. The battery corresponds in position to the first stepped section, and is configured not to overlap the processing unit in a direction of a first axis so as to reduce a thickness of the transmitter.

Abstract: Provided are methods and apparatus for receiving sensor data from an analyte sensor of a sensor monitoring system, processing the received sensor data with time corresponding calibration data, outputting the processed sensor data, detecting one or more adverse conditions associated with the sensor monitoring system, disabling the output of the sensor data during the adverse condition time period, determining that the one or more detected adverse conditions is no longer present in the sensor monitoring system, retrieving the sensor data during the adverse condition time period, processing the retrieved sensor data during the adverse condition time period, and outputting the processed retrieved sensor data.

Abstract: Methods, devices, and systems are provided for correcting lag in measurements of analyte concentration level in interstitial fluid. The invention includes receiving a signal representative of sensor data from an analyte monitoring system related to an analyte level measured over time, computing rates of change of the sensor data for a time period of the sensor data, computing a rate distribution of the rates of change, transforming the rate distribution into a linear arrangement, determining a best-fit line for the transformed rate distribution, computing a slope of the best-fit line; and using the slope of the best-fit line as a representation of a variability of the analyte level to adjust an amount of lag correction applied to the sensor data. Numerous additional features are disclosed.

Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a fixing indentation containing the sensor, a filler disposed in the fixing indentation to retain the sensor in the holder, and a blocking element disposed between the implantation hole and the fixing indentation to hold the sensor in the holder and restrict the filler in the fixing indentation.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting therethrough the sensor and containing a part of the sensor, and a containing indentation containing the signal output end, wherein the containing indentation has a surrounding wall kept apart from the signal output end to define a space.

Abstract: The present disclosure provides a biosensor for measuring a physiological signal representative of a physiological parameter associated with an analyte. The biosensor includes a working electrode and a counter electrode. The counter electrode including a silver and a silver halide having an initial amount, wherein the initial amount is determined by the following steps of defining a required consumption range of the silver halide during at least one of the measurement periods performed by the biosensor; and determining the initial amount based on a sum of an upper limit of the required consumption range and a buffer amount, so that a required replenishment amount range of the silver halide during the replenishment period is controlled to be sufficient to maintain an amount of the silver halide within a safe storage range.

Abstract: A physiological signal monitoring device includes a base and a transmitter. The base is provided with a biosensor. The transmitter is removably coupled to the base, and includes a casing and an electrostatic-discharge protective unit. The casing has a socket for the biosensor to be removably inserted thereinto. The electrostatic-discharge protective unit is disposed to at least surround the periphery of the socket to dispel static electricity when electrostatic discharge occurs.

Abstract: An implantable micro-biosensor includes a substrate, a first working electrode, at least one second working electrode, and at least one counter electrode. The first working electrode includes a first sensing section driven by a first potential difference to measure a physiological signal. The second working electrode includes a second sensing section driven by a second potential difference to consume an interfering substance. The counter electrode cooperates with the first working electrode to measure the physiological signal, cooperates with the second working electrode to consume the interfering substance, and selectively cooperates with the first or second working electrode to regenerate silver halide.

Abstract: An implantable micro-biosensor a substrate, a first electrode, a second electrode, a third electrode, and a chemical reagent layer. The first electrode is disposed on the substrate and used as a counter electrode. The second electrode is disposed on the substrate and spaced apart from the first electrode. The third electrode is disposed on the substrate and used as a working electrode. The chemical reagent layer at least covers a sensing section of the third electrode so as to permit the third electrode to selectively cooperate with the first electrode or the first and second electrodes to measure a physiological signal in response to the physiological parameter of the analyte.

Abstract: The present invention provides a measuring method for prolonging a usage lifetime of a biosensor to measure a physiological signal representative of a physiological parameter associated with an analyte in a biofluid. The biosensor includes two working electrodes at least partially covered by a chemical reagent and two counter electrodes having silver and a silver halide, and each silver halide has an initial amount.

Abstract: A lancet device including a housing and a lancet structure having a puncturing element. The lancet structure disposed within the housing and adapted for movement between a retaining or pre-actuated position wherein the puncturing element is retained within the housing, and a puncturing position wherein the puncturing element extends through a forward end of the housing. The lancet device includes a drive spring disposed within the housing for biasing the lancet structure toward the puncturing position, and a retaining hub retaining the lancet structure in the retracted position against the bias of the drive spring. The retaining hub includes a pivotal lever in interference engagement with the lancet structure. An actuator within the housing pivots the lever, thereby moving the lancet structure toward the rearward end of the housing to at least partially compress the drive spring, and releasing the lever from interference engagement with the lancet structure.

Abstract: An air-tight desiccating container for storing therein a sensor to be implanted into a subcutaneous portion of a living body is disclosed. The air-tight desiccating container includes a housing, an implanting module, a detachable module mounted on the housing, a bottom cover and a desiccating element. The housing includes an accommodating space and a bottom opening having a first joint portion. The implanting module is mounted in the housing and includes a needle implanting device and a needle extracting device. The detachable module includes the sensor having a chemical reagent for measuring a physiological signal from the living body having a skin surface and a lower mount base configured to assemble the sensor thereon. The bottom cover is detachably coupled to the bottom opening, and has a second joint portion.

Abstract: A venous positioning projector includes an infrared light source module, a light splitting element, an infrared light image capture module, a processor, and a visible light projection module. The infrared light source module outputs a first infrared light to a target surface. The infrared light image capture module includes a filter and an infrared light image capture element. The light splitting element transmits a second infrared light reflected by the target surface to the filter. The infrared light image capture element receives the second infrared light passing through the filter. The processor generates venous image data according to the first infrared light and the second infrared light received by the infrared light image capture element. The visible light projection module generates a visible light based on the venous image data. The visible light is transmitted to the target surface through the light splitting element to generate a venous image.

Abstract: Provided are a blood sample guiding instrument and a blood test kit which enable blood ejected from a finger to be guided to a storing instrument. A blood sample guiding instrument used in a blood test kit includes a cylindrical body in which a first opening and a second opening communicating with the first opening are defined and which comes into contact with a finger; and a clamping portion that is attached to an outer circumferential surface of the cylindrical body, clamps a finger, and presses the cylindrical body against the finger.

Abstract: Provided is an integrated sample collection device for self-collection and analytical pre-processing of a fluid sample, such as a blood sample from a user. A housing is configured to be held by a user, such as a single hand of a user. A contact-activated penetrating member is disposed at least partially in the housing and configured to penetrate skin. A capillary tube is disposed at least partially in the housing and configured to collect blood released by the penetrating member that penetrates the skin. A vacuum-assisted blood collection container can be fluidically connected to the capillary tube for receiving at least a portion of the collected blood. One or more stabilizing/pre-processing agents are provided for stabilizing/pre-processing collected blood in the capillary tube, the vacuum-assisted blood storage container, or both.

Abstract: Systems and methods to improve a user's mental state are disclosed. The method includes playing a segment of a musical performance to a user. The method also includes detecting one or more arm movements of the user, the one or more movements corresponding to movements conducting the musical performance. In response to detecting the one or more movements, the method includes determining a current mental state of the user, and obtaining one or more changes to one or more musical elements of the musical performance that improve the current mental state of the user. The method also includes applying the one or more changes to the one or more musical elements to the segment of the musical performance, and playing the segment of the musical performance to the user.

Abstract: The present disclosure is directed to the first methods and systems for diagnosing a patient being affected by a brain injury from a blast with greater accuracy that previous methods. The methods and system include an automated, non-invasive method for assessing the variance of a patient's ocular motility relative to a matched cohort of unaffected subjects, and using the variance in one or more ocular motility metrics to calculate a score that indicates a likelihood that the patient suffers from a blast brain injury. The score, referred to as a BIS, discriminates between affected an unaffected subjects with a sensitivity of greater than about 85%, a specificity of greater than 75%. The ROCAUC of the BIS is greater than 0.85.

Abstract: Among the various aspects of the present disclosure is the provision of a method for detecting neurodegenerative diseases, disorders, or conditions. Briefly, the present disclosure is directed to a non-invasive method for measuring foveal area and thickness, which has been shown to correlate with the detection of biomarkers used in the detection of neurodegenerative diseases such as Alzheimer's disease and clinical dementia.

Abstract: A method of constructing a value representative of a local epileptogenic network index (LENI). The method is implemented by an electronic device that includes a processor and a memory. The method includes: obtaining, in the form of connectivity matrices, dynamic functional networks, which are representative of electrical signals measured for a predetermined number of points of interest, called nodes, within a cerebral cortex during a given time period; grouping the nodes, as a function of topological properties of said networks, within groups of nodes called modules; and calculating the local epileptogenic network index (LEND as a function of local functional connectivity characteristics of said nodes, modules and networks.

Abstract: An electric toothbrush includes a brush head at an end of a handle, an acceleration sensor and/or a rotation sensor that detect(s) movement parameters of the electric toothbrush, a wireless communication interface that wirelessly transmits recorded data comprising the detected movements parameters of the electric toothbrush in a processed state and receives treatment mode data for operating the electric toothbrush, a pressure sensor that detects a contact pressure applied by the brush head to teeth and/or gums, at least one first outputting device that visually outputs signals or commands in accordance with the detected contact pressure or in accordance with the detected movement parameters, and at least one second outputting device that haptically outputs signals or commands, in the form of vibrations, in accordance with the detected contact pressure or in accordance with the detected movement parameters.

Abstract: A method for detecting a respiratory event of a subject comprises: receiving a bio-impedance measurement signal (S2) dependent on respiratory action from the subject; extracting (306) at least one time-sequence of the bio-impedance measurement signal (S2); and for each extracted time-sequence: comparing (308) the bio-impedance measurement signal (S2) with each of a plurality of machine learning models in an ensemble of machine learning models to form a set of predictions of occurrence of a respiratory event, wherein each prediction is based on comparing the bio-impedance measurement signal (S2) with one machine learning model, wherein each model correlates features of time-sequences of a bio-impedance measurement signal (S2) with presence of a respiratory event and wherein each model is trained on a unique data set of training time-sequences; deciding (310) whether a respiratory event occurs in the extracted time-sequence based on the set of predictions.

Abstract: A Neonatal CNN (N-CNN) is provided for detecting neonatal pain emotion based upon facial recognition. A cascaded N-CNN is trained using a Neonatal Pain Assessment Database (NPAD) to automatically identify a neonatal patient experience pain in real-time. These results show that the automatic recognition of neonatal pain provided by the embodiments of the present invention is a viable and more efficient alternative to the current standard of pain assessment.

Abstract: Systems and methods for delivering a drug with a tracer or contrast agent are disclosed herein, as are systems and methods that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.

Abstract: A method for capturing patient feedback for a medical treatment includes: receiving user instructions indicating a symptom being treated, a symptom score for the symptom being treated, and an indication of a beginning of a treatment session; receiving patient feedback comprising an updated symptom score for the symptom being treated and/or absence or presence of one or more of a plurality of attributes; storing the received patient feedback and a time in the treatment session at which the respective patient feedback was received; repeating the receiving of patient feedback and storage of data during the treatment session; and receiving a user instruction indicating an ending of the treatment session, wherein an alerting module alerts a user of the computing device for input of patient feedback after a predetermined period of time has elapsed following receipt of patient feedback without a subsequent receipt of patient feedback.

Abstract: A system for monitoring a patient includes a sensor unit having a housing and sensors disposed in or around the housing; and a base having a shell and configured and arranged to be adhesively attached to skin of the patient. The sensors can be used to monitor physical therapy and rehabilitation of the patient. The sensor unit can provide information to a patient or clinician device to facilitate the monitoring. The sensor data can be used to determine measurements such as tilt angle of the sensor unit and range of motion measurements (such as extension, flexion, or forces associated with movement) of the anatomical region to which the sensor unit is attached. The sensor data can also be used for automated identification or classification of exercises performed by the patient.

Abstract: Included are: an action detection unit (16) detecting action information preset for each type of discomfort factor from behavior information corresponding to a discomfort factor of a user; a discomfort period estimating unit (20) acquiring an estimation condition (174) for a discomfort period (?t) of the user corresponding to the action information and estimating the discomfort period (?t) using history information corresponding to the estimation condition (174); a discomfort estimator (21) estimating a discomfort state of the user based on multiple pieces of biological information (X, Y) of the user; a discomfort estimator learning unit (22) estimating reaction time (tx, ty) to discomfort factors in the multiple pieces of biological information (X, Y) based on the discomfort period (?t), and synchronizing input timing of the multiple pieces of biological information (X, Y) to the discomfort estimator (21) based on the discomfort period (?t) and the reaction time (tx, ty); and a discomfort determination unit

Abstract: An electronic device is provided. The electronic device includes a housing including a first surface facing a first direction, a second surface facing a second direction opposite to the first surface, and a third surface connecting the first surface and the second surface to form a space in the housing, a display viewable in the first direction through the first surface of the housing, a printed circuit board (PCB) disposed in the space, a glass covering at least a part of the second surface of the housing and including a fourth surface facing the first direction and a fifth surface facing the second direction, a high-hardness member disposed on the fifth surface, a first conductive member disposed between the high-hardness member and the glass, and a second conductive member disposed on the fourth surface and electrically connected to the PCB.

Abstract: A physiological signal monitoring device includes a base, a biosensor mounted to the base, a transmitter, and a sealing unit. The base is adapted to be mounted to a skin surface of a host. The biosensor includes a mounting seat and a sensing member that is mounted to the mounting seat. The sensing member is adapted to be partially inserted underneath the skin surface of the host for measuring an analyte of the host and to send a corresponding physiological signal. The transmitter is for receiving and transmitting the physiological signal, and has a bottom portion. The transmitter covers the base while the bottom portion faces the base. The sensing member is coupled to the transmitter. The sealing unit is used to seal paths through which a liquid possibly penetrates into an interior of the physiological signal monitoring device so as to avoid damage of the device.