Abstract: Compositions and blends of biopolymers and copolymers are described, along with their use to prepare biocompatible scaffolds and surgically implantable devices for use in supporting and facilitating the repair of soft tissue injuries.

Abstract: Compositions comprising perforated, unseparated amnion/chorion; perforated, separated amnion; and perforated, separated chorion derived from the placenta and methods of preparing and using those compositions are provided. Perforation of placental tissue before or during processing may allow for one or more benefits such as more efficient removal of blood remnants, retention of wound healing and tissue regeneration components, better handling characteristics, or improved healing capacity. The present invention also includes methods of healing a wound of the skin, eye, nerve, tendon, or dura comprising applying the perforated compositions of the invention to the wound.

Abstract: A method of making infused bone fibers employs the following steps: cutting or shaving whole bone into bone fibers, washing the bone fibers, demineralizing or decalcifying at least partially the whole bone or bone fibers and infusing the bone fibers with a supernatant of biologic material or a polyampholyte cryoprotectant or a combination of both to create infused bone fibers. The step of infusing includes exposing the bone fibers to a negative pressure or vacuum to draw the supernatant and/or the polyampholyte cryoprotectant into the bone fibers, or alternatively, exposing the demineralized whole bone to a positive pressure to drive the supernatant and/or the polyampholyte cryoprotectant into the bone. The resultant method creates an infused bone grafting composition having bone fibers taken from whole bone, demineralized or decalcified at least partially and infused with one or more of a supernatant of biologic material or a polyampholyte cryoprotectant or both.

Abstract: This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which said substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.

Abstract: Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone. Example constructs include extracellular matrix on a synthetic scaffold, in which the ECM is secreted from MSCs seeded onto the synthetic scaffold. Also provided are methods of making the present bone grafts and scaffolds. Further provided are methods of promoting bone healing and treating wound healing, by administering the present bone grafts and constructs to a mammal in need thereof Also provided are kits that include the present bone grafts and/or constructs, or components thereof.

Abstract: A composition includes a dual crosslinkable hydrogel that includes a plurality of polymer macromers, which are crosslinked with a first agent and a second agent different than the first agent, wherein the crosslinks formed using the second agent are reversible and repeatable to allow the mechanical properties of the hydrogel to be dynamically adjusted.

Abstract: An implantable drug-delivery device for repairing a severed peripheral nerve. The drug-delivery device includes a matrix formed of a biopolymer and an erythropoietin (EPO) entrapped in the matrix. After in vivo implantation of the drug-delivery device, the EPO elutes over a period of 1 day to 12 weeks. Also disclosed is a method for repairing a severed peripheral nerve using the implantable drug-delivery device.

Abstract: Aspects include methods of fabricating antibacterial surfaces for medical implant devices including patterning a photoresist layer on a silicon substrate and etching the silicon to generate a plurality of nanopillars. Aspects also include removing the photoresist layer from the structure and coating the plurality of nanopillars with a biocompatible film. Aspects also include a system for preventing bacterial infection associated with medical implants including a thin silicon film including a plurality of nanopillars.

Abstract: A system and method for a diaphragm-based fluidics aspiration system is disclosed. The aspiration system includes a waste reservoir configured to hold a vacuum pressure; an aspiration connection; a vacuum pinch valve including a first outlet fluidically coupled to the waste reservoir; a second outlet fluidically coupled to the aspiration connection; a fluid channel; and an actuator configured to alter a cross-sectional area of the fluid channel.

Abstract: Surgical tools are provided herein that are configured to apply suction and irrigation at a surgical site during the course of a surgical procedure. A surgical tool can include a handle that has a suction flow path configured to provide suction therethrough and an irrigation flow path configured to provide irrigation therethrough. The suction flow path and the irrigation flow path can share a common path along at least partial lengths thereof. An elongate shaft can extend distally from the handle and can have an inner lumen that is in communication with the suction flow path and the irrigation flow path. The inner lumen can thus be configured to provide suction from the suction flow path to a surgical site to remove matter therefrom and to provide irrigation from the irrigation flow path to the surgical site to provide fluid thereto.

Abstract: A manual pump apparatus and method for extracting breastmilk is disclosed. A pump head comprises a funnel-shaped breast shield portion and a neck portion leading to a collection container. A deformable elastic component is sealed within an opening formed in the neck portion and manipulated by a mechanical actuation device to engage the user's nipple within the pump head to simulate the suckling of an infant and to compress the nipple to control edema. The deformable elastic component is configured to move into the interior volume of the neck portion under an applied pressure such that the deformable elastic component compresses the nipple to control nipple edema. The deformable elastic component is also configured to move away from the axial center of the neck portion under an applied pressure to create a volume to create suction and extract breastmilk in a manner that closely replicates the suckling of an infant.

Abstract: Described are peritoneal dialysis systems and methods that involve the use of crossflow filtration of a used dialysate withdrawn from the peritoneal space of a patient. The filtration forms a retentate containing amounts of an osmotic agent and a permeate containing amounts of water and nitrogen-containing waste products of the patient. The retentate, or a fraction thereof, can be returned to the peritoneal space of the patient to return osmotic agent to the patient. The permeate, or a fraction thereof, can be discarded to discard nitrogen-containing waste products of the patient.

Abstract: A process includes removing air bubbles from extracorporeal blood via chemical entrapment of nitrogen (N2) gas.

Abstract: The present disclosure relates to a method for removing blood and/or blood mixture from an extracorporeal blood circuit with a blood filter used for the blood treatment of a patient, after completing the blood treatment session. The blood filter includes a blood chamber and a spent dialysate chamber, between which a membrane is arranged. The blood chamber is connected to an arterial blood line, a venous blood line, a dialysis inlet line, and a dialysate outlet line. The venous blood line is fluidly connected to the dialysis inlet. The method includes displacing the blood and/or the blood mixture from the blood chamber by introducing substituate into the arterial blood line, and generating a pressure difference in the blood filter with a lower pressure in the spent dialysate chamber and a higher pressure in the blood chamber.

Abstract: An integrated system for assessing wound exudates from the wound of a patient is described. The system may contain functionality to detect, process and report various wound parameters. The system also may make treatment determinations based on these findings. The system may detect one or more physiological values of the wound exudates from the wound of the patient. The system may means for comparing the one or more detected physiological values to predetermined physiological values in order to obtain a comparison result in real time. The system may include a processor 15 which provides an electronic signal based on a comparison result in which the electronic signal may correspond to guidelines for treating the wound 13. The system may be integrated with other wound treatment devices, such as negative pressure wound therapy devices (NPWT) 9.

Abstract: Disclosed herein are systems and methods for providing reduced or negative pressure, and more particularly cyclical reduced pressure, to treat a wound. The system can include a wound dressing, a fluid collection container, a suction source, filters, and conduits. In addition, the system can include a control device and sensors. The sensors may be configured to monitor certain physiological conditions of a patient such as temperature, pressure, blood flow, blood oxygen saturation, pulse, cardiac cycle, and the like. Application of cyclical reduced pressure between two or more values below atmospheric pressure may be synchronized with the physiological conditions monitored by the sensors. Certain embodiments of the system utilize an air reservoir and one or more valves and pressure sensors or gauges to allow for rapid cycling of the level of reduced pressure within the wound dressing between two or more reduced pressure values.

Abstract: An accessory for a nasal mucus aspirator includes an accessory body suitable to be gripped and a terminal nozzle placed at a distal end of said accessory body and suitable to be at least partially inserted into a nostril of a user. In the accessory body, there are formed a compressed air inlet passage suitable to be fluidically connected to a compressed air source for receiving a flow of air at a positive pressure, said compressed air inlet passage defining a constriction so as to generate a Venturi effect, and an aspiration duct flowing into said constriction and fluidically connected to the terminal nozzle so as to generate a negative pressure due to the Venturi effect suitable to aspirate the mucus.

Abstract: Fluid supply systems and methods for therapeutic fluid delivery systems, including those used for negative pressure wound therapy (NPWT) systems and methods.

Abstract: Systems and methods for treating cellulite including an apparatus that applies or a method involving disrupting, stretching, re-orienting or tearing septa to eliminate or reduce the appearance of cellulite. In one approach, an expandable member is placed between tissue layers to stretch or tear septa connecting tissue layers between which fat deposits are contained.

Abstract: A container for holding a liquid, in particular an infusion liquid or irrigating liquid, comprising a liquid phase containing the liquid and a gas phase, wherein, in the operating position, a liquid opening is formed in the lower region of the container and wherein the container has a gas opening. The gas opening is formed by a gas pipe which is inseparably connected to the container and has a first gas pipe end and a second gas pipe end. The first gas pipe end extends into the gas phase of the container and is provided with a closure. The second gas pipe end leads to the outside of the container.

Abstract: An adapter for a surgical hand piece having a single lumen work tip with an open end and a small lateral hole is designed to convert the work tip to infusion/aspiration (I/A) cleanup of lens epithelial cells after phacoemulsification. The adapter is in the form of a sleeve adapted to be slid over the distal end of the work tip. The sleeve includes at least one aspiration hole located toward the distal end of the sleeve. When the distal end of the sleeve is at a first distance L1 from the distal end of the work tip, aspiration occurs through the aspiration hole of the sleeve and the open end of the work tip. When the distal end of the sleeve is at a second and smaller distance L2 from the open end of the work tip, aspiration through the open end of the work tip is blocked by the sleeve and aspiration occurs through the aspiration hole of the sleeve and the lateral hole in the work tip.

Abstract: A trans-anal irrigation (TAI) system adapted for self-use includes an irrigation head supplied with water from a reservoir by a pump or by gravity feed. The irrigation head has either internal or external structures for releasably retaining the head in a user's rectum during the water flow portion of a TAI process. A guide member arm may be provided for manipulating the irrigation head for both insertion and removal. The irrigation head is reliably attached to the guide member arm. The guide member arm may include an integral manual pump.

Abstract: A system for measurement automation of a fluid injected into a patient includes a reservoir, a fluid injection apparatus, and a measurement automation apparatus. The fluid injection apparatus includes a delivery conduit, an injector for injecting the fluid into the patient, a diverter assembly disposed between the delivery conduit and the injector, and a connector between the diverter assembly and delivery conduit. The diverter assembly is configured to divert at least a portion of the fluid away from an injection fluid path between the injector and the delivery conduit to the reservoir. The measurement automation apparatus includes an injector sensor module, a reservoir sensor module, a processor configured to receive the data from the sensor modules, and a display.

Abstract: A wearable medical device may be unpacked, prepared, and/or used while being grasped with a single hand position. For example, the device may be removed from a package, primed, and/or adhered to the skin of a user while being grasped with the single hand position. Optionally, the device may be used with a single hand. Optionally, the device includes a delivery interface (for example, including a needle tip and/or a skin contact surface). Optionally, the device includes a protector that preserves sterility of the delivery interface. Optionally, the cover can be removed with a single hand. Optionally, removal of the cover is performed with the same hand position as placement of the device on a delivery site.

Abstract: A medical pump device for delivering a medical fluid includes a base body and elastomeric hollow membrane secured to the base body and arranged in such a way that a pump volume for filling with medical fluid is formed between the base body and hollow membrane. The hollow membrane, in an at least partially filled state of the pump volume, is elastically extended and exerts a delivery pressure on the pump volume. The medical pump device has a sensor system set up to determine the extension of the hollow membrane such that, by using the extension that is thus determined, filling level information concerning the filling state of the pump volume is determined. The medical pump device can be used in infusion or transfusion arrangements.

Abstract: An infusion pump is provided for pumping fluid through an administrative set at a desired flow rate over a specified duration, and includes a pumping mechanism for releasably receiving and for exerting a pulsing force on the administrative set, thus pressurizing a portion of the set for creating a flow of fluid from a set outlet. A controller is connected to and is configured for operating the pumping mechanism, the controller determines a pulse frequency based on a volume of fluid infused over a portion of the specified duration and the desired flow rate, outputs a control signal to the pumping mechanism for operating the pumping mechanism based on the determined pulse frequency, determines a first pulse frequency based on the desired flow rate; and adjusts the first pulse frequency based on the volume of fluid infused to provide a second pulse frequency being different from the first pulse frequency.

Abstract: An inspection machine checks and inspects whether an infusion pump is accurately operated and does not require maintenance in a closed system without drainage. This inspection machine includes a syringe and a plunger and moves the plunger backward when an infusion flows into the syringe through a communication hole by the driving of an infusion pump to measure a flow rate by the backward movement amount. An outer peripheral surface of the plunger has an annular recess and a seal ring is fitted thereto. The seal ring is expanded by receiving a liquid pressure of the infusion to be sealed and the plunger is coaxially centered on the syringe. The flow rate of the infusion is accurately reflected to the plunger movement amount. Further, since the infusion is stored in the syringe and does not drip, drainage equipment is not required and an inspection operation can be performed anywhere.

Abstract: The invention relates to administration of clinical anesthesia. Particular embodiments provide systems and methods for controlled delivery of a combination of an analgesic agent and a hypnotic agent. More specifically, the invention relates to closed-loop control systems/methods for automatically controlling the administration of a combination of a hypnotic agent and an analgesic agent in a clinical anesthesia setting which incorporate feedback based on one or more indirect measures/indicia of analgesia. The invention further relates to such control systems/methods that account for limitations of such indirect measures/indicia of analgesia.

Abstract: A system for managing a patient's glucose level includes a glucose sensor to generate and store data signals for measurements of the patient's glucose level made by the glucose sensor; an insulin pump; and sensor electronics operatively coupled to the glucose sensor, the sensor electronics comprising a memory storing one or more predetermined characteristics associated with the sensor electronics; and a computing device in electronic communication with the sensor electronics. The computing device comprises a processor configured to operate the sensor electronics to (i) receive the generated data signals, (ii) obtain the one or more predetermined sensor characteristics from the memory and (iii) execute a closed-loop algorithm to provide insulin delivery instructions to an insulin pump by at least using the data signals and predetermined characteristics.

Abstract: One or more embodiments of the disclosure relate, generally, to a diabetes management system. The diabetes management system may include a computing device that is configured to receive data relating to prior insulin use of a user and calculate a sliding scale glucose correction based, at least in part, on the data relating to prior insulin use.

Abstract: An electronic insulin delivery device receives glucose data from a glucose monitor and sets a bolus dose amount. The device may take the form of an insulin pen with automatic priming and accurate dosing provided by a motor in connection with an encoder. The device may communicate with and be controlled by a smart phone device. The smart phone device provides a user interface to receive user data including patient weight, insulin to carbohydrate ratio and exercise factor, and to send instructions to the device, including dose amount. The dose amount is determined taking into account glucose level and trend, and other factors. The delivery device may be in continuous communication with the glucose monitor and smart phone to provide for near real-time adjustments in glucose treatment. Glucose data, insulin injection data, and other relevant data may be stored and accessible to interested parties.

Abstract: Missed meal bolus reminders or alerts require a user to access the user's pump and/or remote control to clear the reminder/alert even when the user skipped a meal such that no meal bolus was needed. CGM data can be leveraged such that the missed meal bolus alert is only triggered when glucose levels rise in response to consuming the meal within the programmed time window. Therefore, the alert is only provided when a meal is actually consumed and no bolus has been delivered. This further allows the user to be alerted sooner, i.e., as soon as glucose levels rise a predetermined amount or passed a predetermined threshold indicating consumption of a meal as opposed to only at the end of the programmed window.

Abstract: A blood glucose control system is configured to modify therapy provided to a subject. The system can cause first therapy to be delivered by the blood glucose control system to a subject during a first therapy period. The first therapy can be delivered based at least in part on a first value of a control parameter used by a control algorithm to generate a dose control signal. The system can determine a first effect corresponding at least in part to the first therapy and autonomously generate a second value of the control parameter. The system can cause second therapy to be delivered by the blood glucose control system to the subject during a second therapy period, wherein the second therapy is delivered based at least in part on the second value of the control parameter.

Abstract: Contemplated herein is a medication mixing device which can include a housing having therein a first chamber containing a first medicament component and a second chamber provided containing a second medicament component provided with a sealing structure selectively isolating the first chamber from the second chamber. The sealing structure can include a first sealing component having a first sealing interface and a second sealing component having a second sealing interface wherein a first compression force can be applied to the first and second sealing components causes the sealing interfaces to form a seal. The first compression force can then be configured to allow the first sealing component and the second sealing component to maintain at least one degree of freedom with respect to one another.

Abstract: Embodiments of a syringe-based device for delivering fluid include a housing, a port, the port being positioned at about the distal end of the housing, a plunger assembly, the plunger assembly including, a plunger seal, a valve, and a cannula, a first fluid reservoir, where the first fluid reservoir retains a first type of fluid, a syringe including a syringe body, a syringe port, a plunger, and a second fluid reservoir, the second fluid retaining a second type of fluid, and where the syringe transitions from a first configuration in which a first portion of the first fluid type is delivered through the port, to a second configuration in which the second type of fluid in the second fluid reservoir is delivered through the port, to a third configuration in which a second portion of the first fluid type is delivered through the port.

Abstract: A system for serially injecting liquids includes a syringe body, proximal and distal stopper members disposed in the syringe body, a first liquid in a distal chamber, a second liquid in a proximal chamber, a plunger member, and a needle hub assembly coupled to a distal needle interface of the syringe body. The plunger member includes a needle retention feature disposed in a plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latching member configured to couple the needle to the hub. Manipulating the plunger member to insert the proximal stopper member distally relative to the syringe body initially expels the first liquid, then the second liquid. The needle is at least partially retractable into plunger interior.

Abstract: The invention relates to an arrangement for detecting a position of a plunger (4) relative to a bung (3) in a drug cartridge (1), comprising a proximity sensor (5) located close to a distal end (6) of the plunger (4) facing the bung (3) and aligned to receive light reflected by the bung (3).

Abstract: An actuating device having integrated plunger is configured to be removably mounted to an automatic mixing device for a syringe. The actuating device includes lower and upper housings, a trigger member, a lockout ring, a mixing biasing member, a delivery plunger, a plunger biasing member, and a mixing plunger. The mixing plunger is releasably engaged with the trigger member in an initially locked state and engageable with at least one seal of the mixing device. The trigger member is operable to initiate decompression of the mixing biasing member and engagement of the mixing plunger with the at least one seal of the mixing device. The delivery plunger may also be activated to expand from a first, collapsed configuration to a second, expanded configuration by actuation of the trigger member.

Abstract: An add-on for a self-injector including an adaptor and a bent fluid path is provided. The adaptor includes at least one coupling sized and shaped to couple the adaptor to a fluid reservoir. The bent fluid path is configured at a first end to penetrate tissue and coupled at a second end to the adaptor. The add-on coupled to the fluid reservoir forms an integral self-injector cartridge unit configured to be sterilized and filled with an injectable. The adaptor is configured to couple to a self-injector at least one of a plurality of reservoirs having different sizes and tip types.

Abstract: The present utility model provides an electrically powered needle-free injector (100), comprising: a needle-free injector body (120); and a needle-free injection end (130) extending distally from the needle-free injector body (120) for medicine administration, the needle-free injector body (120) comprises: a housing (3), an inside of which is divided into a pressurized injection chamber (123) and a motor chamber (124); a pressurized injection assembly (170) disposed within the pressurized injection chamber (123); a needle-free injector locking mechanism (180) at least partially disposed within the pressurized injection chamber; and a motor assembly (190) disposed within the motor chamber (124). The present utility model has a beneficial effect that it may provide a power source for the needle-free injector to electrically take medicine and inject by a built-in motor; it works reliably, is used conveniently, and has a small size.

Abstract: An automatic feedback mechanism for a medicament delivery device that notifies a user of a start of expulsion of medicament from a medicament container is presented where a plunger rod, a tubular extension member arranged to receive the plunger rod in the radial space, and wherein the tubular extension member has flexible tongues configured to releasably lock the plunger rod in a pre-tensioned state. The tubular operation member is arranged to receive the tubular extension member, where the tubular operation member in a first position is arranged to press the flexible tongues radially inwards to lock the plunger rod in the pre-tensioned state. A first resilient member is arranged inside the plunger rod to exert a force in the proximal direction. A signal generating member is arranged to partially surround the plunger rod such that movement of the signal generating member distally hits the inner distal surface generating an audible signal.

Abstract: A device that prevents the accidental activation and lockout of an autoinjector. In illustrative embodiments, a resistance unit is configured to resist deployment of the needle until a critical force is applied by the user to the autoinjector, at which point, the resistance of the resistance unit is overcome. Continuous application of force by the user after the resistance is overcome drives the delivery device to the injection site where the medication is administered.

Abstract: Needle shield mechanism for an auto-injector comprising, a tubular housing (10), a needle shield (12) movably arranged in the housing (10), between a retracted state and an extended position, a releasable spring-biased container carrier assembly movably arranged relative to the housing (10) from an initial position to a penetrating position, wherein the container carrier assembly prevents the needle shield (12) from moving to the extended position when the container carrier assembly is in the initial position, and wherein the container carrier assembly allows the needle shield (12) to move to the extended position when the container carrier assembly is in the penetrating position.

Abstract: A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.

Abstract: An electronic vapor provision system includes a vaporizer for vaporising liquid for inhalation by a user of the electronic vapor provision system; a power supply comprising a cell or battery for supplying power to the vaporizer; a sensor for measuring the rate of airflow through the electronic vapor provision system as a result of the inhalation by the user; and a control unit for controlling the power supplied to the vaporizer based on a cumulative airflow for this inhalation by the user, wherein the cumulative airflow is determined based on the measurements of airflow rate by the sensor. Such a system allows the user control over the amount of vaporized liquid obtained in a given inhalation based on the cumulative airflow for the given inhalation.

Abstract: The aerosol-generating article includes a housing with a first end and a second end. The housing defining a cavity. A first volatile substrate is in a first frangible capsule, where the first frangible capsule is between the first end and a middle section of the housing. At least a portion of a pre-vapor formulation retention medium is between the first end and the middle section of the housing. The vapor-generating article is configured to be connected to an electrically-operated vapor-generating device, where the vapor-generating article is configured to allow air to be drawn through from the first end to the second end if a negative pressure is applied to the second end. The vapor-generating system includes the vapor-generating article.

Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.

Abstract: An accessory device for delivering medications from press and breath metered-dose inhalers (pMDIs), including those medications containing hydrofluoroalkane propellants. The device includes a collapsible flexible bag to which is attached a bidirectional mouthpiece and an adaptor that receives the press and breath MDI. The mouthpiece contains a reed that functions as an audible signal, and a screen to prevent inhalation of unwanted particles. The adaptor positions the press and breath MDI at an angle to direct the aerosol spray toward the center of the collapsible flexible bag. When the press and breath MDI is triggered, it discharges the aerosolized medication into the center of the collapsible flexible bag which is then inhaled by the user through the mouthpiece. This collapses the bag. The reed emits an audible sound if the user inhales above a pre-determined flow rate to maximize medication delivery and ensure dose-to-dose consistency.

Abstract: Disclosed herein is a device configured to impart flavoring to an airstream admitted the device prior to the airstream reaching an aerosol generator of the device, the device thereby operable to deliver a flavored aerosol from an outlet.

Abstract: The aerosol-generating article include a plurality of elements coaxially aligned and assembled within a wrapper, the article having an outlet end and a distal end upstream from the outlet end. The article includes a liquid aerosol-forming substrate, and a liquid retention medium for retaining the liquid aerosol-forming substrate. The wrapper is formed from a sheet of liquid-impervious material, the liquid retention medium being in a first element of the plurality of elements.