Abstract: The present invention relates to a device for treating an aneurysm of a human or mammal patient, wherein the aneurysm may self expand, leading to the aneurysm bursting with high risk for death of the human or mammal patient. The device is provided with an implantable member to be placed in connection with the outside of a blood vessel having the aneurysm, and to exercise a pressure on the outside of the blood vessel having the aneurysm, a measuring device or sensor for measuring or sensing an expansion of the aneurysm, and a monitoring system for monitoring the expansion of the aneurysm based on a signal received from the measuring device or sensor.

Abstract: A mask-based diagnostic apparatus is provided for detecting a biomarker contained in exhaled breath of a test subject. An exhaled breath condensate (EBC) collector converts breath vapor received from the lungs and airways of the test subject into a fluid biosample. The EBC collector including a thermal mass, a condensate-forming surface and a fluid conductor disposed on the condensate-forming surface. A fluid transfer system receives the fluid biosample from the EBC collector. A biomarker testing unit receives the fluid biosample from the fluid transfer system and tests the fluid biosample for a target biomarker. A testing system support is provided for supporting the EBC collector, the fluid transfer system and the biomarker testing unit. The testing system support is configured and dimensioned to fit inside a face mask.

Abstract: A breath collection device can detect changes associated with pathogenesis of a disease, such as COVID-19, including biomarkers of immune response for respiratory symptoms, central nervous system injury, and/or peripheral nervous system injury in user breath and/or odor. The breath collection device can detect concentrations of alcohol, acetone, and carbon monoxide in user breath samples. A breath sample can be received in an internal bladder of the device for sensor analysis. Concentrations of alcohol, acetone, and carbon monoxide can be determined by calibrated calculation. A detection method for alcohol, acetone, and carbon monoxide can provide a non-invasive, rapid, and selective detection of gases in a variety of applications in virus detection as well as agricultural and homeland security.

Abstract: An apparatus and method for measuring a ground reaction force may be disclosed. The apparatus may include a ground reaction force measurement unit configured to calculate a first ground reaction force value using a human body proportional mass parameter value for a subject to be measured and inertial data measured for the subject, a foot pressure measurement unit configured to sense a foot pressure for the subject and calculate foot pressure data using the foot pressure, and a final ground reaction force calculation unit configured to calculate a second ground reaction force value using the foot pressure data and the first ground reaction force value.

Abstract: There is provided a system for accurately assessing a person's body condition on the basis of measured values of the person's walk. The present invention is a system for evaluating a measurement target walk and the system includes: a measurement apparatus that continuously measures the measurement target walk; and an arithmetic operation apparatus that executes an arithmetic operation based on an output of the measurement apparatus, wherein the arithmetic operation apparatus: computes a walking cycle of the walk; executes extraction of a walk in a state where the walking cycle is stable; and evaluates the measurement target on the basis of a result of the extraction.

Abstract: An intravaginal ejaculation latency time and vaginal clonus monitoring device has a monitoring sleeve, an integrated sensor set and a processing circuit integrated module. The integrated sensor set is located in the monitoring sleeve. The processing circuit integrated module is detachably connected with the monitoring sleeve, and has a real-time clock chip, a central processing unit, a data transmission component and a power module. The integrated sensor set, the real-time clock chip and the data transmission component are all connected with the central processing unit. The power module is used for providing a working power supply.

Abstract: A hospital bed is configured to monitor data from a second patient support based on the one or more alarms set by the user. The hospital bed detects whether an alarm triggering event occurred based on the monitored data. In response to a determination that the alarm triggering event occurred, the hospital bed will provide a signal indicative of the alarm triggering event to a nurse call system.

Abstract: This technical solution relates to a computer and medicine field, in particular, to the software and hardware system for rehabilitation of patients with upper limb post-stroke cognitive impairment. The technical result is improving efficiency of rehabilitation of patients with upper limb post-stroke cognitive impairment.

Abstract: The disclosed systems and methods include providing a plurality of sounds at varying intensity levels, and receiving an input indicative of a perceived volume level of the plurality of sounds as perceived by a user. The disclosed systems and methods include determining, based on the received input, a plurality of user volume levels that indicate a hearing sensitivity of the user. The disclosed systems and methods include providing a background sound, and concurrently while providing the background sound, providing a stimulus sound. The disclosed systems and methods include receiving an indication that the user perceived the stimulus sound. The disclosed systems and methods include determining a change in the hearing sensitivity of the user based on receiving the indication that the user perceived the stimulus sound, and predicting an onset of a migraine attack of the user based on determining the change in the hearing sensitivity of the user.

Abstract: A wideband acoustic immittance measurement apparatus including an ear probe having an acoustic output port for emitting sound into an ear canal and an acoustic input port for receiving sound from the ear canal, a loudspeaker that is acoustically connected with the acoustic output port, a microphone acoustically connected with the acoustic input port for generating an audio signal as a function of sound received at the acoustic input port, and a processor for controlling the loudspeaker to emit sound spanning a frequency range and receiving the audio signal of the microphone, determining a complex acoustic admittance Y(f)=G(f)+jB(f) as a function of frequency f based on the emitted sound and the received audio signal, and identifying at least one middle ear resonance based on both the real and imaginary part of the determined acoustic admittance as a function of frequency f.

Abstract: A method of non-invasively monitoring advanced glycation end-product (AGE) concentrations includes providing incident light to patient tissue at one or more excitation wavelengths and monitoring the one or more emission responses at one or more emission wavelengths. Based on the emission responses monitored, a ratio is calculated based on a ratio of the first emission response to the second emission response.

Abstract: Devices, systems, methods and kits for releasably mounting a medical device on the body or skin of a user are provided. Embodiments include a holder or mounting unit or structure that retains a medical device in a fixed position on a body part of a user or host, such as on the surface of the skin, and/or provides physical and/or electrical coupling to one or more additional components which may be operatively positioned above and/or below the surface of the skin.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: A method of determining structured behavior from network adjacency matrices is described. A method of detecting physiological signals from a subject is described.

Abstract: A system for performing measurements on a biological subject, the system including: at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject; and, an actuator configured to apply a force to the substrate to cause the microstructures to at least one of pierce and penetrate the stratum corneum.

Abstract: A method of monitoring a body tissue includes determining, with reference to a position of an m-th light emitting unit, a position of an n-th light reception unit, and a distance between the m-th light emitting unit and the n-th light reception unit, an area and a depth of the body tissue which corresponds to the m-th light emitting unit and the n-th light reception unit; measuring hemodynamics of the body tissue at the area and the depth corresponding to the m-th light emitting unit and the n-th light reception unit based on the optical signal generated from the m-th light emitting unit and detected by the n-th light reception unit; and estimating an activity of the body tissue on an area basis and a depth basis based on the hemodynamics at at least one of the area and the depth of the body tissue.

Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.

Abstract: Aspects of the present disclosure provide a fluid collection device including a rigid or semi-rigid structure having a wedge-shaped leading edge to fit under a patient's buttocks while the patent is supine. At least one receptacle is provided in the structure to receive fluid discharged by the patient. A measurement apparatus associated with the at least one receptacle indicates a threshold volume of fluid collected by the fluid collection device.

Abstract: The application concerns a stickpack-type packaging comprising an elongate foil tube (12) having two transverse sealing joints (16,18), such that a tightly closed fill space (20) is provided in the foil tube (12) for storing a product. It is proposed that a single disposable test strip (22) is arranged in the fill space (20), wherein the test strip (22) has a chemistry pad (26) for detecting an analyte in a sample, and the chemistry pad (26) is arranged at a distance at least from one of the transverse sealing joints (16,18).

Abstract: A blood collection item comprises a furan resin selected from the group consisting of: poly (ethylene 2,5-furan dicarboxylate) (PEF), poly (butylene 2,5-furan dicarboxylate) (PBF), poly (trim ethylene furan dicarboxylate) (PTF), poly (propylene 2,5-furandicarboxylate) (PPF), and poly (neopentyl 2,5-furandicarboxylate) (PNF). The item may be a syringe having an injection-molded plunger and barrel, a blood collection tube, or a tube holder.

Abstract: A human body support has a plurality of electrodes arranged in an array and spaced longitudinally with respect to the human body. The array extends from an inferior position to a more superior position along the body. A sensor measures a parameter of the human body that is capable of indicating the presence of drowsiness. A controller has an input connected to the sensor for receiving a signal representing the sensed parameter and has outputs connected to each of the electrodes. The controller detects whether the sensed parameter is within a range indicating the presence of drowsiness and applies a wave of electrical stimuli against the human body in response to detection of a sensed parameter within the range. The electrical stimuli cause periodic tightening and relaxing of proximate muscles as the wave progresses in a direction from an inferior location on the human body toward a more superior location.

Abstract: The present invention relates to the concept of a stress digital twin. The stress digital twin of an individual is a digital, i.e. computer-implemented system for monitoring a stress level of a living individual on the basis of at least data directly measured on the body of the living individual and by performing a thermodynamic evaluation of the stress entropic load. The stress entropic load is a thermodynamic parameter representing an amount of entropy generated within the living individual due to adaptation to a whole set of environmental influences in a given scenario at a given point of time. Based on a comparison with pre-collected reference data (library data), the invention triggers actions such as withdrawal or replacement of individuals acting in a given scenario or the issuing of alerts.

Abstract: A method (1500) for deriving a mental state of a subject is disclosed. The method comprises receiving (1502) a bio-signal from the subject; calculating respective statistical variations of at least two physiological parameters derived from the bio-signal; determining (1504) an arousal level of the subject based on the calculated statistical variations of the at least two physiological parameters; deriving a time-domain heart rate variability signal from the bio-signal for calculating at least two heart rate variability parameters; determining (1506) a valence level of the subject based on the at least two heart rate variability parameters; and deriving (1508) the mental state from the arousal level and valence level. A related apparatus is also disclosed.

Abstract: The present invention relates to an ECG monitor device including a removable electrode pad and a monitor element configured for use with a single lead that receives and processes information associated with a plurality of leads.

Abstract: Neural network based heart rhythm classifiers are described. The neural network is configured to receive an electrocardiogram segment and to output an indication of whether the electrocardiogram segment represents a heart rhythm that is suitable for treatment by a defibrillation shock. Preferably, the received electrocardiogram segment is not transformed or processed prior to its reception by the neural network and no features of the electrocardiogram are identified to the neural network. In some embodiments, the received electrocardiogram segment is the sole input to the neural network. In various embodiments, the neural network is configured to classify electrocardiogram segments obtained while CPR was being performed on the patient. Classifiers that output a characteristic of CPR are also described. Such outputs may include an indication of whether CPR was being performed while the ECG was being detected, compression depth, etc. The described classifiers are well suited for use in defibrillators.

Abstract: A method and device for monitoring a vital sign of a user, the method including: acquiring a sensor signal related to a vital sign; sampling the sensor signal to obtain data related to the vital sign; and in response to a key event, adjusting the method for collecting and processing the sensor signal.

Abstract: The invention relates to methods and devices for providing parameters that indicate a higher likelihood of a postoperative delirium occurring. According to a first aspect of the invention, the following steps are provided: detecting (401) at least one EEG signal at the head of the patient; determining (402) the intraoperative alpha peak frequency of the EEG signal, wherein the alpha peak frequency in the power spectrum of the EEG signal is the frequency in the alpha band for which the power is greatest; checking (403) whether the determined intraoperative alpha peak frequency is significantly lower than a predefined reference value of the alpha peak frequency; and in the event of this, providing (404) a corresponding information in the form of a parameter that shows a higher likelihood of a postoperative delirium occurring. A second aspect of the invention evaluates the change in power of the alpha band after an anesthetic-inducing drug has been administered.

Abstract: The present disclosure provides a brain wave analysis device with a computation section configured to compute a first ratio and a second ratio from a spectrum obtained by performing frequency analysis on time-series data of brain waves measured at a predetermined location of a head of a subject.

Abstract: The application discloses an electronic device set including a modular appliance. The modular appliance includes a first power supplier, a processing device, and a connector. The power device includes a first power supply terminal, a second power supply terminal and at least one first signal terminal. The the processing device is configured to perform data acquisition and electrical stimulation on a biological subject via the at least one first signal terminal. The connector includes contacts coupled to the first electrode, the second electrode, the first power supply terminal, the second power supply terminal, and the at least one first signal terminal, respectively.

Abstract: A wearable module assembly for an optical measurement system includes a first wearable module, a second wearable module, and a connector. The first and second wearable modules each include a light source configured to emit a light pulse toward a target within a body of a user, a housing that houses the light source and the plurality of detectors and includes a substantially hexagonal surface that faces a surface of the body of the user when the wearable module assembly is worn by the user, and a plurality of detectors each positioned at a fixed distance from the first light source and each configured to detect a set of photons included in the light pulse after the set of photons are scattered by the target. The connector directly connects the first wearable module and the second wearable module at mutually-facing side surfaces of the respective housings.

Abstract: A medical device comprising a memory, a processor communicably coupled to the memory, and the processor configured to execute instructions to evaluate one or more patient data inputs relating to a first specific disease, compare the one or more data inputs to a set of values from at least one database using at least one computational algorithm, train the at least one computational algorithm for estimating a diagnosis of the patient based on the first specific disease, determine a first diagnostic score for the patient for the specific disease using the at least one computational algorithm, diagnose the patient as having the specific disease when the first diagnostic score for the first specific disease is above a first value, and provide the diagnosis for the patient as an output.

Abstract: Systems and methods for non-invasive and/or non-contact measurement of a subject's tremor in the context of therapeutic intervention is presented. The system includes a memory, a communications interface, a sensor to measure a signal associated with position or motion of an extremity of the subject, and a processor. The processor is configured to receive the signal from the sensor. The processor is further configured to communicate, via the communications interface, the signal, login credentials, and position or motion data to a remote server coupled to a remote electronic health record database. The remote server is configured to receive the signal from the sensor. The processor is configured to receive an analysis that quantified the severity of tremor.

Abstract: A volatile organic compound collector can include a collector material configured to collect volatile organic compounds given off from a patient's skin; a wrapping configured to isolate the collector material from an external environment; a heater comprising a heating element, the heating element configured to emit a thermal pulse to desorb the volatile organic compounds from the collector material; and a mesh layer configured to prevent the collector material from contacting the patient's skin, wherein the collector material is received between the wrapping and the mesh layer.

Abstract: A method, comprising receiving at least one of a signal relating to a first cardiac activity and a signal relating to a first body movement from a patient; triggering at least one of a test of the patient's responsiveness, awareness, a second cardiac activity, a second body movement, a spectral analysis test of the second cardiac activity, and a spectral analysis test of the second body movement, based on at least one of the signal relating to the first cardiac activity and the signal relating to the first body movement; determining an occurrence of an epileptic event based at least in part on said one or more triggered tests; and performing a further action in response to said determination of said occurrence of said epileptic event. Further methods allow classification of epileptic events. Apparatus and systems capable of implementing the method.

Abstract: The present disclosure relates to methods and devices to detect perforation of the bowel, for example, resulting from surgical procedures, such as laparoscopy, diagnostic procedures, such as colonoscopy, medical conditions, such as diverticulitis, and trauma. The present disclosure also relates to filtration systems and electrical connector assemblies for use in the methods and devices.

Abstract: A method of tracking progress of labor includes placing a magnetic field sensor array (14), which includes an array of magnetic sensors (16), close to a woman who is carrying a fetus, placing tracking devices (20, 22, 23, 24) at positions relative to the fetus, generating a magnetic field from each of the tracking devices (20, 22, 23, 24), each of the magnetic fields being unique to a particular one of the tracking devices (20, 22, 23, 24), sensing the magnetic fields of the tracking devices (20, 22, 23, 24) with the magnetic field sensor array (14), analyzing sensed magnetic fields of the tracking devices (20, 22, 23, 24) to identify positions of the tracking devices (20, 22, 23, 24) with respect to the fetus, and using the positions of the tracking devices (20, 22, 23, 24) with respect to the fetus to determine progress of labor of the woman.

Abstract: A method for wireless detection of a subject rising from a rest state includes producing transmitted wireless signals from one or more transmitting antennas, receiving reflected wireless signals at one or more receiving antennas, and processing the reflected wireless signals in a computer. The computer iteratively aligns candidate trajectories with a template trajectory until the current and previous template trajectories are within a predetermined distance from each other. A final template trajectory is used to determine a lying-down surface exit initiation area, a lying-down surface exit initiation area exit time, a TUG plane or radius entry time, and a TUG time.

Abstract: A device is disclosed that can detect and treat disordered breathing in a patient. The device can include at least one contact adapted to make contact with a portion of an oral cavity of a patient, and a control circuit configured to: in a first mode, detect a presence of disordered breathing in the patient based, at least in part, on a first signal received from the at least one contact; and in a second mode, provide electrical stimulation via the at least one contact to a portion of the patient's upper airway based on a detection of the presence of disordered breathing.

Abstract: Determining the progression of reflux disease in the esophagus of a patient includes identifying the location of an endoscopic gastroesophageal junction in the esophagus, removing a length of tissue of the esophagus that includes a portion of the endoscopic gastroesophageal junction, and identifying the proximal limit of tissue containing cardiac epithelium. Determining the length of the squamo-oxyntic gap of the biopsied tissue can involve measuring the length of tissue extending between the proximal limit of tissue containing gastric oxyntic epithelium to the proximal limit of tissue containing cardiac epithelium. A linear relationship can be determined from a slope of a line extending between a first data point and a second data point that can determine a target age of the patient when the lower esophageal sphincter will have a certain length.

Abstract: A system and method for allowing any surgeon, including those surgeons who perform a fewer number of a replacement procedure as compared to a more experienced surgeon who performs a greater number of procedures, to provide an improved likelihood of a favorable outcome approaching, if not exceeding, a likelihood of a favorable outcome as performed by a very experienced surgeon with the replacement procedure. Force sensing is included to aid in quantifying installation of an implant, particularly a cup into a pelvic bone.

Abstract: Systems, devices, and methods for biomonitoring are disclosed herein. In some embodiments, a device for monitoring a user's health comprises a patch including a substrate configured to couple to the user's skin, and an array of microneedles carried by the substrate. The array of microneedles can be configured to access interstitial fluid in the user's skin and generate a first electrical signal indicative of at least one analyte in the interstitial fluid. The device can include a pod configured to releasably couple to the patch, the pod having at least one sensor configured to generate a second electrical signal indicative of a physiological parameter of the user. The pod can further include a processor configured to receive and process the first and second electrical signals to generate health measurements for the user. The pod can also include a communication unit configured to transmit the health measurements to a remote device.

Abstract: A system for treating and/or monitoring a patient includes a patient physiological parameter monitoring patch and a companion device. The patient physiological parameter monitoring patch including an energy harvesting module, an energy storage module, a sensor module and a communication module. The energy harvesting module harvesting energy from one or more ambient sources, the energy being storable in the energy storage module and usable by one or more components of the patient physiological parameter monitoring patch. The sensor module senses one or more physiological parameters of the patient and the communication module can transmit the sensed data. The companion device can receive the sensed physiological parameters and can send the same to a remote device or store the same.

Abstract: A catheter tube unit 2a of the present invention is housed in a catheter tube 2 of an electrode catheter 1, and used for the catheter tube whose distal end is made bendable and stretchable through a wire 5 fixed to the distal end, when the wire is manipulated from a base end side. The catheter tube unit includes the wire, a long and integrated structure 10 including at least a core tube 6 through which the wire is inserted, a plurality of lead wires 7, 7 . . . arranged around an outer circumference of the core tube and connected to electrodes 4, 4 . . . , and a sheath 8 that envelopes the plurality of lead wires overall at least over the exterior, and an exterior tube 11 composed of an extrusion-molded article arranged over the outer circumferential face of the structure, while placing the structure as a core.

Abstract: Intravascular imaging catheters are provided that include a distal sheath portion having a lumen that is configured to optionally receive a guidewire or an imaging assembly. The distal sheath portion may be configured to have dimensions such that when a guidewire is inserted through the lumen and extends through a distal exit port, the distal sheath portion may be employed as a microcatheter. External tissue may be imaged at a location at or near the distal end of the catheter, enabling, for example, the controlled imaging of a total occlusion, and the positioning of the distal end (and guidewire) within a true lumen associated with a total occlusion. A structural stop may be provided at or near the distal end of the distal sheath portion to prohibit extension of the imaging assembly out of the distal exit port, while permitting the extension of the guidewire through the distal exit port.

Abstract: An physiological measurement device provides a device body having a base, legs extending from the base and an optical housing disposed at ends of the legs opposite the base. An optical assembly is disposed in the housing. The device body is flexed so as to position the housing over a tissue site. The device body is unflexed so as to attach the housing to the tissue site and position the optical assembly to illuminate the tissue site. The optical assembly is configured to transmit optical radiation into tissue site tissue and receive the optical radiation after attenuation by pulsatile blood flow within the tissue.

Abstract: At least one sound generator operatively coupleable to a corresponding at least one auscultatory sound-or-vibration sensor provides for generating a corresponding at least one sound signal that is applied to the corresponding at least one auscultatory sound-or-vibration sensor.

Abstract: An auscultatory sound-or-vibration sensor electronic test signal applied to a sound generator generates an acoustic sound signal, responsive to which an auscultatory sound-or-vibration sensor in proximity to the sound generator generates a corresponding auscultatory sound signal. The auscultatory sound-or-vibration sensor electronic test signal incorporates a plurality of frequency components, each frequency component of which incorporates an integral number of wavelengths and is terminated following a duration of time corresponding to the integral number of wavelengths after that frequency component is applied to the corresponding sound generator. A determination of whether or not the auscultatory sound-or-vibration sensor is functioning properly is made responsive to an analysis of a Fourier Transform of the auscultatory sound signal.

Abstract: A filtering method includes the following steps: receiving an sound signal; decomposing the sound signal into a primary lung sound signal and a reference heart sound signal; adjusting the reference heart sound signal according to a weighted value to generate an adjusted heart sound signal; and subtracting the adjusted heart sound signal from the primary lung sound signal to generate a filtered lung sound signal.

Abstract: Methods and devices for determining a measurement time period, receiving a plurality of signals associated with a monitored analyte level during the determined measurement time period from an analyte sensor, modulating the received plurality of signals to generate a data stream over the measurement time period, and accumulating the generated data stream to determine an analyte signal corresponding to the monitored analyte level associated with the measurement time period are provided. Systems and kits are also described.

Abstract: Implementations described herein disclose an artificial intelligence (AI) based method for generating an oxygen saturation level output signal using the trained neural network. In one implementation, the method includes receiving a photoplethysmographic (PPG) signal, the PPG signal including a red PPG signal and an infrared PPG signal, generating an input feature matrix by performing time-frequency transform of the PPG signal, training a neural network using the input feature matrix and an oxygen saturation level input signal, and generating an oxygen saturation level output signal using the trained neural network.