Abstract: A device for applying compression to a patient's limb includes a sleeve and a control unit configured to supply pressurized fluid to the sleeve using the following inflation/deflation process: inflating the at least one chamber from an initial pressure to a first pressure; maintaining the at least one chamber at the first pressure for a first predetermined amount of time; changing the pressure in the at least one chamber from the first pressure to a second pressure, wherein the second pressure is greater than the initial pressure; maintaining the at least one chamber at the second pressure for a second predetermined amount of time; changing the pressure in the at least one chamber from the second pressure to the first pressure or a third pressure greater than the second pressure; maintaining the at least one chamber at the first pressure or the third pressure for a third predetermined amount of time; and deflating the at least one chamber to zero pressure or a fourth pressure.

Abstract: A heel protector (100) includes a leg engaging section (101) and a foot engaging section (102) intersecting at a heel receiver (103). The leg engaging section (101) and the foot engaging section (102) define a leg insertion aperture (104). The leg engaging section (101) defines at least one aperture (203) disposed in an ankle region (205) to permit a connection tube (1002) extending from an inflatable bladder (901) of a compression device (800) to pass therethrough. The heel protector (100) and compression device (800) work together as a rehabilitation system (1300).

Abstract: A system is disclosed for stimulating venous and arterial circulation in a patient to prevent deep vein thrombosis, which includes a first inflatable garment sleeve configured to be wrapped around the left calf of the patient and having a first air input tube extending from an exterior surface thereof, a second inflatable garment sleeve configured to be wrapped around the right calf of the patient and having a second air input tube extending from an exterior surface of the second garment sleeve, a portable pump for cyclically inflating the first and second garment sleeves, and a bifurcated tube assembly for connecting the portable pump to the first and second air input tubes of the first and second garment sleeves.

Abstract: A massaging chair assembly includes a pad that is positionable on a seat in a vehicle. A plurality of massage units is each integrated into the pad and each of the massage units abuts the user when the user sits on the pad. Each of the massage units orbits about a central point when the massage units are turned on to massage the user. A heating element is integrated into the pad and the heating element heats the pad to warm the user when the user sits on the pad. A control unit is integrated into the pad and the control unit is in electrical communication with each of the massage units and the heating element. A remote control is provided and the remote control is in wireless communication with the control unit for controlling operational parameters of the massage units and the heating element.

Abstract: An intramuscular stimulation needling device for chronic pain relief. The needling device can include a stepper motor, a needle, and a control unit. The needle can poke an affected muscle tissue and driven by a stepper motor in reciprocating manner. In each cycle, the needle moves a pre-determined distance forwardly in a first half cycle and retracts to original position in a second half cycle. The control unit can accelerate of the needle one or more times in the first half cycle at spaced intervals and decrease the velocity in the reverse pattern in the second half cycle.

Abstract: A method of forming an acupuncture needle includes forming an acupuncture needle having a needle body having a needle tip portion at a leading end thereof, and a needle grip attached to a base end portion of the needle body. A cross-sectional shape crossing a longitudinal direction of the acupuncture needle at a middle of the needle grip in the longitudinal direction is an ellipse. A groove portion is provided along an outer circumference of the needle grip. When using as an acupuncture needle with a long needle grip, the needle grip is maintained without being separated at the groove portion. When using as an acupuncture needle with a short needle grip, the needle grip is bent with a bending load direction in a minor axis direction of the ellipse to separate the needle grip at the groove portion.

Abstract: An acupuncture needle is an acupuncture needle including a needle body having a needle tip portion at a leading end thereof, and a needle grip attached to a base end portion of the needle body. A cross-sectional shape crossing a longitudinal direction of the needle grip is an ellipse.

Abstract: A package that is configured to store and dispense fluids. The package includes a container and a dosing dispenser for closing an opening to the container. The dosing dispenser includes a closure removably coupled to the container and an anti-suction valve fixed to the container that is configured to minimize formation of a complete seal between a user's mouth and an upper surface of the anti-suction valve so that sufficient suction to remove fluid from the container is blocked.

Abstract: A sealed assembly for pill crushing and delivering and a method for using thereof are provided. The assembly includes: a connecting valve with different diameters, including a first end, a valve and a second end provided with a syringe-abutting interface, wherein, an opening diameter of the first end is larger than that of the second end; and a pill-crushing carrier including a sealed cavity having only one filling-in opening, the pill-crushing carrier has a first state when separated from the connecting valve and the filling-in opening is exposed for pills delivering into the carrier, and a second state when the filling-in opening is connected to the first end of the connecting valve, crushed and dissolved pill powders in the sealed cavity can be taken out through the connecting valve. The assembly can crush pills and dissolve powders in a sealed cavity, deliver powder-dissolved liquid and prevent powders from dispersing.

Abstract: A dispensing system including a handheld dispenser and a dispenser controller. The handheld dispenser may have a housing, a cartridge removably disposed within the housing and containing a dose form to be dispensed, the dose form with an active pharmaceutical ingredient (API), the cartridge having an internal piston movable within a reservoir containing the dose form and a port through a distal tip in communication with the reservoir, the distal tip being sized and configured to be inserted into the user's mouth. A motor disposed in the housing moves the piston to dispense a volume of the dose form from the cartridge through the port. The dispenser controller adjusts the volume of the dose form dispensed by the dispenser based on information about effectiveness of the API in treating a condition of the user.

Abstract: A medication dispensing system is provided with several cooperating components which help to accommodate the responsible handling of medications. These systems include a user interface to receive input from the user and to present appropriate information/notices/alarms. Further, physical controls and multiple sensors are provided to detect tampering, misuse, and attempts to inappropriately access medications contained within the dispensing system. This misuse can thus be detected, and appropriate notifications can be provided, where appropriate. Further, by adding network communications capabilities, notices can be widely communicated to others, and operation of the medication dispensing system can be controlled and/or monitored remotely.

Abstract: An ultraviolet photopolymerizable composition for soft tissue attachment includes trimethylolpropane tris(3-mercaptopropionate) (TMTMP), a photoinitiator, a solvent, and one or more of trimethylolpropane trimethacrylate (TMPTMA), pentaerythritol triacrylate (PETA), dopamine methacrylamide (DMA), and n-phenethylmethacrylamide (PEMAD). Coating a substrate with a polymeric coating includes contacting a substrate with the ultraviolet photopolymerizable and irradiating the composition with ultraviolet radiation to yield a polymeric coating on the substrate. Treating a substrate includes contacting the substrate with the composition and irradiating the composition with ultraviolet radiation to yield a polymeric coating on the substrate.

Abstract: Provided are monomers useful for dental materials that include a compound in which a core and a specific terminal group are bonded to each other directly or via a linking group, wherein the core is a C1-200 polyvalent organic group having a valence of not less than 3 containing an oxygen atom or a nitrogen atom in which an atom bonded to the terminal group or the linking group is the oxygen atom or the nitrogen atom; the terminal group is a specific (meth)acryloyl group-containing group, a (meth)acryloyl group, a C1-20 hydrocarbon group or a hydrogen atom, and the terminal group needs to meet specific requirements; and the linking group is a specific divalent group, and when the compound contains a plurality of linking groups, the linking groups may be the same as or different from each other. Compositions, dental materials and kits are also provided.

Abstract: A wet wiper for cleaning accumulated oral debris from removable dental appliances. The wet wiper comprises a water insoluble substrate and a physiologically acceptable cleansing composition, wherein the cleansing composition comprises: (i) a liquid carrier consisting of a solution of water and ethyl alcohol, wherein the ethyl alcohol is about 3% to about 90% by weight of the cleansing composition, and wherein the water is q.s. to 100%; (ii) about 0.

Abstract: The invention described presents a device and the method for obtaining the constituent structures to generate a fragrance supply assembly by means of the absorption of the fragrance in a polymer which, when exposed to an environment, disseminates the fragrance over time within the surrounding environment where said output is gradual. Additionally, the constituent materials of the device are biodegradable. The specification describes the device and the method for preparing the components and the assembly which allow to aromatize for longer periods of time than the devices that are currently on the market, and without the need to use electrical elements for the release of the fragrance in the desired space with a greater amount of aroma and controlled dosage.

Abstract: A dentifrice composition with tin, calcium, and a pH of greater than 7. A dentifrice composition with tin, fluoride, calcium abrasive, water, and a pH of greater than 7. Dentifrice compositions with a high tin ion availability. Dentifrice compositions comprising stannous fluoride and/or stannous chloride in combination with calcium carbonate.

Abstract: Non-aqueous dentifrice compositions comprising a source of calcium ions and a source of phosphate ions such as a bioactive glass, a humectant such as glycerine, a hydroxyethyl cellulose polymer and a pyrogenic silica. The calcium source and the phosphate source together are precursors for the in situ formation of a desensitizing/remineralizing agent on teeth in the oral cavity. The compositions are useful in remineralizing teeth and in the treatment of dentine hypersensitivity.

Abstract: Described herein are oral care compositions which contain antibacterial amounts of zinc, a calcium carbonate base; a gum system; and a natural ingredient component.

Abstract: An anhydrous shampoo composition includes two surfactants selected from (a) sodium cocoyl isethionate, and (b) at least one of sodium lauroyl methyl isethionate and sodium cocoyl methyl isethionate; and propanediol. The compositions can further include glycerin, gaur and citric acid. The shampoos compositions are capable of foaming when combined with water during use for cleaning and conditioning keratinous fibers.

Abstract: The present invention relates to a topical composition. More particularly the present invention relates to antimicrobial composition for providing benefits against malodor. Accordingly, the present invention provides a topical composition comprising; a. at least one compound selected from a biphenol; and, b. at least one coinage metal compound.

Abstract: An oil-in-water emulsion comprising a liquid C10-C22 fatty acid, an emulsifier and a water-soluble metal salt capable of forming a water-insoluble salt with the C10-C22 fatty acid at a pH of greater than 6 and thereby giving an antiperspirancy benefit on topical application to the skin.

Abstract: A cosmetic kit includes a skin staining composition of (i) a monovalent salt of alginic acid, a water-soluble colorant, and water and (ii) an activating composition of water and a cosmetically acceptable salt of calcium or magnesium. Also disclosed is a method for cosmetically treating or making up the human skin by using the cosmetic kit useful in making up lips, eyelids and eyebrows.

Abstract: Provided are a composition including a compound of the following chemical formula as an active ingredient, and a method of enhancing a skin barrier by applying it to the skin:

Abstract: A hair conditioning composition that is silicone free is described. The composition includes a fatty acid ester, a cationic surfactant and optional high melting fatty compound, an optional organic acid, an optional cationic polymer, an optional zwitterionic compound and an optional antidandruff compound.

Abstract: The present disclosure relates to compositions and methods for treating and/or cleansing keratinous materials. The compositions comprise at least one carboxylate anionic surfactant, at least one secondary surfactant other than the at least one carboxylate anionic surfactant, at least one glyceryl ester, and a cosmetically acceptable solvent, wherein the at least one carboxylate anionic surfactant and the at least one glyceryl ester are present in a weight ratio ranging from about 0.50 to about 1.00.

Abstract: The invention relates to aqueous skin cleansing compositions. Specific amounts and chain length of acyl glycinate and acyl glutamate when used in specified ratios, have been found to unexpectedly enhance lather volume and texture, as well as provide superior mildness.

Abstract: A method of colouring an eyebrow, the method comprising: (I) applying to the eyebrow a colouring composition comprising: (a) one or more dye compounds selected from Acid yellow (23), Food Red (17), Acid Blue (9) and Acid Green (25); (b) an organic acid; (c) an alkylene carbonate; (d) an alcohol; and (e) glycerol and/or urea

Abstract: The present invention provides a hair care active agent comprising taxifolin glucoside and N-acetyl tyrosine and a hair care composition comprising said hair care active agent. The hair care agent is able to reduce the occurrence of grey and white hair in an individual.

Abstract: The invention relates to a cosmetic composition comprising a low molecular weight silk fibroin and a cosmetically acceptable carrier; wherein said low molecular weight silk fibroin comprises at least 85 parts by weight peptides of molecular weight less than 2500 Da, where amino acid sequence of at least 50 wt % of said peptides is GAGY, GAGAGAGY, GAGVGAGY or AWSSESDF and where said silk fibroin is produced by a process comprising the steps of: (i) mixing an aqueous solution comprising 0.01 to 20 wt % of a high molecular weight silk fibroin of weight average molecular weight 6 to 100 KDa with ochymotrypsin at temperature of 25 to 45° C.

Abstract: The present invention provides compositions and methods for treating a dermatological disorder or disease.

Abstract: Compositions and methods are disclosed herein for treating female pattern hair loss with a topical composition used to remove minoxidil from the hairs. A method for diagnosing subjects in need of a topical composition used to remove minoxidil from the hair treatment and guiding the application of a topical composition used to remove minoxidil from the hair treatment are also described. Additionally, a method for diagnosing a subject at high risk for female pattern hair loss who will likely respond to topical composition used to remove minoxidil from the hair prophylactic treatment is described. A method for combining the composition described herein with topical minoxidil for androgenetic alopecia is described. In addition, cosmetic compositions are described as well as methods of improving the appearance of hair following application of minoxidil.

Abstract: The invention relates to a self-invertible inverse latex comprising, as an inverting agent, surfactant species of the polyglycerol ester family, the alkyl chain of which has from 8 to 18 carbon atoms, with polyglycerols having 1 to 10 glycerol units, and the use thereof as a thickening and/or emulsifying and/or stabilizing agent for a cosmetic, dermopharmaceutical or pharmaceutical topical composition, and cosmetic, dermopharmaceutical or pharmaceutical topical compositions comprising same. Also disclosed are surfactant compositions comprising polyglycerol esters, the alkyl chain of which has from 8 to 18 carbon atoms, and polyglycerols having 1 to 10 glycerol units.

Abstract: Emulsion-based personal care compositions and methods for preparing the same are provided. The personal care compositions may include an emulsion of a hydrophobic phase and a hydrophilic phase. The hydrophobic phase may include an emulsifying system including a first nonionic surfactant and a second nonionic surfactant, where a weight ratio of the first nonionic surfactant to the second nonionic surfactant is from about 0.9:1 to about 1.1:1. The first nonionic surfactant may be glyceryl monostearate, and the second nonionic surfactant may be PEG-100 stearate.

Abstract: A lip cosmetic that preferably has smooth feeling of use, gives shine, has no limitation of the container that can be used, and that further allows even coloring with little color transfer. A lip cosmetic composition having an inner phase and an outer phase, wherein the inner phase includes: A) a low-viscosity oil agent that does not dissolve a solidifier, and the outer phase includes: B) the solidifier; C) a high-viscosity oil agent that dissolves the solidifier; D) a binder oil that dissolves the low-viscosity oil agent as component A at 90° C. but not at 25° C.; and E) a coloring material, and the total amount of components A, B, C, D and E contained in the lip cosmetic composition is 80 mass % or more.

Abstract: The present invention relates to a process for shaping keratin fibers using a composition comprising at least one silicone acrylic copolymer.

Abstract: The present invention relates to a composition comprising at least one silicone acrylic copolymer and at least one particular block copolymer. The present invention also relates to a process for treating keratin fibers using a composition comprising at least one silicone acrylic copolymer and at least one particular block copolymer.

Abstract: The present invention relates to a composition for treating keratin fibers, preferably hair, comprising (a) tartaric acid, (b) at least one aromatic alcohol, (c) at least one organopolysiloxane selected from polydialkylsiloxane, polydiarylsiloxane, and polyalkylarylsiloxane, and (d) at least one amino-modified silicone.

Abstract: Cosmetic composition comprising one or more particular non-volatile oils, one or more volatile oils and one or more lipophilic dyes, methods and uses thereof.

Abstract: A three-part method of cleaning a user's teeth and/or gums is disclosed. First, a user applies a tonic of essential oils to the user's teeth and/or gums by either brushing, rubbing, rinsing and/or flossing with the tonic thereby destroying harmful bacteria. Second, the user brushes with a toothpaste having nano-hydroxyapatite being particles of 50 nanometers or smaller. The nano-hydroxyapatite is absorbed into the surface opening inside dentinal tubules of the teeth. Third, the user seeds their mouth with an oral probiotic having beneficial bacteria. The third step must come after both the first and second steps.

Abstract: The present invention concerns a cosmetic method for dyeing or making up keratin fibres, in particular eyelashes and/or eyebrows and preferably eyebrows, comprising the application, to the keratin fibres, of at least: a) A dyeing cosmetic composition A comprising, in a physiologically acceptable medium, one or more natural dye(s) chosen from the group consisting of neoflavonoids, gallic tannins and catechic tannins, and/or proanthocyanidins and the derivatives of same and the mixtures thereof, or preferably one or more plant extracts containing same, and advantageously an antioxidant, b) A revealing cosmetic composition B comprising, in a physiologically acceptable medium, at least one iron salt and/or one aluminium salt, in particular an iron gluconate or an iron sulphate, composition A being applied before or after composition B, and preferably before composition B.

Abstract: A method of delivering a therapeutic agent into the central nervous system through the blood-brain barrier includes implanting an implant within the submucosal space of the olfactory epithelium. The implant can provide sustained drug delivery to the brain. The implant can be placed using a minimally invasive surgical approach.

Abstract: The disclosure provides an effervescent composition adapted for oral use, the composition including an effervescent material; one or more fillers in a total amount of at least about 30% by weight, the one or more fillers including at least one sugar alcohol; at least one active ingredient; and optionally, a lipid in an amount of at least about 20% by weight. Melting effervescent compositions are also provided, which include the lipid.

Abstract: Methods, systems, and apparatus, including combination therapy systems for the treatment of infections. These systems comprising: an ultrasound device capable of producing ultrasonic acoustic pressure; and a biodegradable piezoelectric film comprising polymer-based piezoelectric material, poly(L-lactic acid) (PLLA) nanofiber mesh configured to, when placed in an electrolytically conductive environment comprising water and stimulated with the ultrasonic acoustic pressure, vibrate generating electricity to locally decomposes the water into reactive oxygen species (ROS) to induce a broad-spectrum bactericidal effect.

Abstract: A topical composition comprising a therapeutically-effective amount of at least one cannabinoid and at least one pharmaceutical active component in which the at least one pharmaceutical active component reduces pain and inflammation beyond the benefits provided by the at least one cannabinoid alone. The pharmaceutical active components can be lidocaine, Manuka honey or Stachys byzantina. The topical composition can be in the form of a lotion, cream, stick or rub.

Abstract: An object of the present invention is to provide a microneedle array in which the stability of influenza vaccine is satisfactory and the utilization efficiency of the influenza vaccine is high, and a method of producing the same. According to the present invention, provided is a self-dissolving microneedle array including a sheet portion, and a plurality of needle portions which are present on an upper surface of the sheet portion, in which the needle portion contains a water-soluble polymer, influenza vaccine, and meglumine or a salt thereof, and the influenza vaccine is administered into a body by dissolution of the needle portions.

Abstract: A method of reducing the feeling of vaginal dryness is provided. The method includes a female user suffering from vaginal dryness administering a vaginal care composition to her vaginal introitus and, optionally, external vaginal tissues. The vaginal care composition can comprise an oil-in-water emulsion and a silicone wax having a melting temperature of from about 24° C. to about 50° C. The vaginal care composition can also comprise silicone particles. The vaginal care composition can have a viscosity of from about 20,000 cps to about 200,000 cps.

Abstract: A polyfunctional radical scavenger hydrogel formulation providing extended protection of the extracellular space within a wound site. The polyfunctional radical scavenger hydrogel formulation is generally formed from a hydrogel, a first radical scavenger and a second radical scavenger differing from the first radical scavenger with respect to at least one property. A portion of the first radical scavenger included with the formation and/or second radical scavenger included within the formulation may be dissolved, suspended and/or bonded to a polymer of the hydrogel.

Abstract: The invention provides an aqueous pharmaceutical solution for use in the treatment of diseases of the central nervous system (CNS), the solution comprising at least 5 mg/ml dissolved levodopa, and having a pH in the range of 3.0 to 8.5. Said solution is provided by mixing a) au aqueous stock solution comprising levodopa, said stock solution having a of less than 2.8 at 25° C. and b) an aqueous buffering solution, for increasing the pH of said stock solution, said buffering solution having a pH of at least 4.0 at 25° C. The aqueous pharmaceutical solution is administered to a subject suffering from a disease of the central nervous system (CNS) shortly after mixing of the aqueous stock solution and the aqueous buffering solution. Furthermore, the invention provides a kit for administration of aqueous pharmaceutical solutions to subjects suffering from diseases of the central nervous system (CNS).

Abstract: The present invention relates to a liquid pharmaceutical preparation and a method for administering the pharmaceutical preparation by nebulizing the pharmaceutical preparation in an inhaler. The propellant-free pharmaceutical preparation comprises: (a) active substances selected from umeclidinium bromide and vilanterol trifenatate; (b) a solvent; (c) a pharmacologically acceptable solubilizing agent; (d) a pharmacologically acceptable preservative; and (e) a pharmacologically acceptable stabilizer; and optionally includes other pharmacologically acceptable additives.

Abstract: The present invention relates to a liquid pharmaceutical formulation of hypoglycaemic sulfonamide, intended for oral or ophthalmic administration. The present invention relates in particular to an oral formulation particularly suitable for paediatric use.