Abstract: The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.

Abstract: The present disclosure generally relates in certain embodiments to a magnetic imaging kit for biochemical sensing, e.g., for detection of analytes, via magnetic imaging techniques. For instance, in one set of embodiments, the kit comprises a collection of magnetic imaging agents (e.g. superparamagnetic iron oxide nanoparticles) and linker species (e.g. a catechol, phosphothreonine, and/or derivative thereof) with a molecular weight of less than or equal to 1000 Da, or less than or equal to 500 Da. The magnetic imaging agents may sense the presence of an analyte via aggregation or disaggregation of the two or more magnetic imaging agents. In addition, certain aspects are directed to a method of exposing two or more magnetic imaging agents to a region on or in a subject and imaging the region to determine the analyte.

Abstract: The present disclosure provides imaging agents that are useful for the detection and evaluation of heart conditions, such as myocardial infarction. Upon activation, the imaging agents of the present disclosure may be detected using an ultrasound imaging device.

Abstract: The present invention relates to radiolabeled LPA1 receptor antagonists of Formula (I) or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein, which are useful for the quantitative imaging of LPA1 receptors in mammals.

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.

Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.

Abstract: Provided herein are phospholipid-free small unilamellar vesicle (PFSUV) compositions, including a steroid and a non-ionic surfactant wherein the molar ratio of steroid:nonionic surfactant is between 3:1 to 5:1. Furthermore, the compositions described herein were found to useful for drug loading, drug delivery where preferential targeting of drugs to the liver is of interest.

Abstract: The present invention involves methods and apparatus for destroying or inactivating pathogens in body cavities or on body surfaces using ultraviolet (UV) light of various wavelengths. More particularly, the invention comprises a portable apparatus containing an energy source, UV light emitter, insertion portion and controller. The energy source may be a battery and some embodiments may include a power converter. The UV emitter may be an LED, excimer lamp, laser, laser diode, fluorescent lamp, xenon flash lamp, arc lamp or gas discharge lamp. The insertion portion may be configured to enter certain body cavities and to transmit the UV light to target areas on body surfaces or within body cavities. The device may also incorporate light filters to block unwanted wavelengths. Some embodiments include a light sensor to detect visible and UV light and may measure the intensity and spectral characteristics of the UV emitter.

Abstract: The present invention offers infectious virus mitigation apparatus that utilize one or more 3-dimensional porous metal substrate that impart virus mitigation effect. Fluid that contains or may contain infectious virus traverses through said substrate to achieve virus mitigation effect. Additional virus mitigation effect can be achieved by subjecting said virus mitigation apparatus to suitable wavelength(s) of light that enhance total virus mitigation effect and/or utilizing contoured cover glazing to induce fluid dynamics that can enhance total virus mitigation effect per pass of said fluid through said apparatus. The utility includes a wide variety of practical uses such as filtration of air, water, blood, and other fluids that contain or may contain infectious virus such as coronavirus.

Abstract: A sanitizing system and method are configured to disinfect at least one surface within an area. The sanitizing system and method include a lighting assembly configured to emit disinfecting visible light onto the at least one surface. The disinfecting visible light is configured to neutralize microorganisms on the at least one surface.

Abstract: A method may be provided for inactivating biologically active components in a liquid using low-energy electrons generated by an electron source, the electrons having an acceleration voltage of 25 keV to 300 keV. The method comprises the following steps: a) filling a vessel with a liquid volume; b) applying low-energy electrons to a first partial volume of the liquid filled into the vessel, wherein the first partial volume is a maximum of 10% of the liquid volume in the vessel; c) mixing the first partial volume of the liquid, applied with the low-energy electrons, to the second partial liquid volume in the vessel, which has not been applied with low-energy electrons; d) repeating steps b) and c) several times.

Abstract: A portable sanitizing arrangement is disclosed comprising essentially a protective case for a mobile productivity device such as a smartphone together with an ultraviolet light source for convenient disinfecting of high-touch objects and surfaces. The arrangement further comprises user controls and interfaces to enable the ultraviolet light source to safely emit light at wavelengths known to kill and destroy bacterial and viral species among other potentially harmful microorganisms. The sanitizing arrangement may irradiate the mobile productivity device itself as well as commonly encountered objects and surfaces in work, travel, entertainment and home environments with substantially greater ease and convenience and at potentially lower cost than with known sanitizing devices and methods.

Abstract: A fluid purification system can include a filter comprising photocatalytic material, a light source configured to illuminate the photocatalytic material, and a scattering film configured to scatter light emitted from the light source.

Abstract: The present disclosure includes, systems, devices, and methods for sterilizing objects, such as gaming equipment or gaming pieces. Some aspects include a sterilization device configured to be integrate with, or coupled to, gaming equipment to sterilize a plurality of gaming pieces. The device may include a housing defining a chamber configured to receive a plurality of gaming pieces and one or more light source(s) coupled to the housing and configured to emit ultraviolet (UV) light toward the gaming pieces.

Abstract: A luminaire includes a housing configured to be positioned over an area, the housing including a frame having a first channel for receiving a light emitter. A light emitter is positioned in the first channel. The light emitter is configured to emit ultra-violet light. A reflector assembly is connected to the frame to direct ultra-violet light emitted from the light emitter. At least a portion of the area is located at 0 degrees relative to the light emitter and a majority of the emitted ultra-violet light is emitted from the housing between 90 degrees and 130 degrees relative to the light emitter in a first direction.

Abstract: A sanitation system includes an overhead passenger service unit panel with a concealed light source providing a single wavelength of Ultraviolet light wherein the light source is deployed and sanitation is performed when the aircraft cabin is free of commercial passengers.

Abstract: Ultraviolet (UV) light emission devices and related methods of use. The UV light emission devices disclosed herein are particularly suited for use in disinfecting surfaces and air. The UV light emission devices disclosed herein can be provided in the form factor of a handheld device that is easily held and manipulated by a human user. The human user can manipulate the handheld UV light emission device to decontaminate surfaces, air, and other areas by orienting the handheld UV light emission device so that the UV light emitted from its light source is directed to the area of interest to be decontaminated.

Abstract: A system comprises an ozone conduit in fluid communication with an aircraft door seal configured to seal the ozone conduit to an aircraft door. An ozone source is in fluid communication with the ozone conduit for supplying a flow of ozone gas (O3) to an aircraft interior through the ozone conduit and aircraft door seal. The ozone conduit can be an ozone inlet line, and an ozone outlet line can be in fluid communication with the aircraft door seal for removal of ozone from the aircraft interior.

Abstract: A disinfectant and sanitizer canister system is disclosed. The system may include a pre-pressurized canister being pre-filled with one or more liquid cleaners and one or more propellants. The system may further include a valve sub-system including a dispensing valve and a valve control mechanism. The control mechanism may be configured to regulate the pressure of the pre-pressurized canister to cause the pre-pressurized canister to release the one or more liquid cleaners. The system may further include a dispensing sub-system configured to fluidically couple the pre-pressurized canister to the valve sub-system. The dispensing sub-system may include a dispensing member configured to dispense the one or more liquid cleaners contained within the pressurized canister. The system may further include a metering device, the metering device configured to provide a predetermined amount of pressure to dispense a predetermined metered dose of the one or more liquid cleaners.

Abstract: A sterilization container includes a housing having at least one opening and at least one valve unit for opening and closing the opening. The valve unit is of the electromechanical type having an electromechanical actuator which is controllable or actuated by a control unit. Furthermore, the valve unit has a valve body to which the control unit is coupled, wherein the opening can be opened and can be closed by the valve body, more precisely the actuator.

Abstract: An oral sanitation system may include a case including: a support portion defining a lower end of the case; and a container portion extending from the support portion. The container portion may define a wall extending from the support portion to a top end of the container portion. The oral sanitation system may further include a closure including a lid formed with a peripherally-extending wall; a lower cavity defined by the wall of the container portion; an upper cavity defined by the peripherally-extending wall of the closure; and a light-guiding floor that is substantially transparent to UVC light, the light-guiding floor forming a bottom of the container portion that is surrounded by the wall.

Abstract: A controlled release device and method of use, the device comprising a reservoir wherein the reservoir is divided into one or more chambers; a first active material placed in a first chamber of the one or more chambers and at least one second active material placed in at least one other of the one or more chambers wherein the first active material comprises an active ingredient (AI), wherein the AI is one of an insecticide, a spatial repellent, a herbicide or a larvicide; wherein the at least one second active material comprises one or both of a matrix and an altering material; a permeable membrane covering the first chamber; partitions positioned between adjacent chambers of the one or more chambers for dividing the reservoir into chambers such that full or partial removal of one or more of the partitions results in mixing of the first active material and the at least one second active material to form a mixed active material; a cap positioned over the membrane for sealing the reservoir such that removal of

Abstract: Various embodiments of diffusing devices and scent cartridges are described. The diffusing device can include a cover or retaining ring that magnetically attaches to the diffusing device to hold the cartridge in place. The scent cartridge can include a top plate suspended above the cartridge such that a scent depository of the cartridge is hidden or obscured while the top plate can include artwork or a kinetic arrangement that has a change in visual appearance due to an airflow against or through the top plate.

Abstract: The present disclosure makes it possible to fill a fragrance-holding structure with a liquid fragrance more easily and more appropriately. Provided is a fragrance-filling structure (100) including: an accommodating portion (110) which accommodates a fragrance-holding structure; a fragrance-guiding portion (120) which includes an inclined surface that converges on a fragrance pool and guides a liquid fragrance poured from an outside onto the inclined surface to the fragrance pool; and a first impregnated body (130) which includes one end that enters the fragrance-holding structure and provides the liquid fragrance accumulated in the fragrance pool into the fragrance-holding structure using a capillary phenomenon.

Abstract: A device to provide sterilized and purified breathable air and to disinfect exhaled air and includes a housing having a first and second opening. The housing includes at least one partition having a plurality of holes, and within the housing such that a plurality of compartments is formed between the first opening and the second opening, and at least one ultraviolet (UV) light source positioned in each of the plurality of compartments. The UV light source is UVC LED lights to emit UVC light of a predefined wavelength within the plurality of compartments to sterilize and purify the air while flowing through the housing. The device includes a mask fluidically coupled to the second opening of the housing using a flexible second pipe to provide the purified air. The device includes one-way valves at the second opening of the housing, and two one-way valves at the outlets of the mask.

Abstract: An air sanitation device may be utilized for sanitizing air particularly in environments where individuals may be in close proximity to one another. The device may include an internal chamber with an air inlet, an air outlet, and an air flow path defined between the inlet and the outlet. The chamber may be pressurized, for instances through an adjustable vacuum. The chamber may include one or more sources of sanitizing radiation, which may be a UV light emitter. Reflective coating may be provided around the internal chamber to improve the coverage of UV light, or other sanitizing radiation. The air flow path may follow a channel whose internal surface may include the reflective coating.

Abstract: A air purification system, whose air flow pipeline made of highly reflective and low absorptive material for UVC or UVB light acts also as a UV light waveguide, with a UVC and/or UVB LED built inside the pipeline, is invented. The system is based on the design concept of maximizing UV light exposure dosage to deactivate all the bioaerosols in the air flow pass through the system. The proposed system can be easily integrated into travel pillow, backbag, handbag, belt bag as well as air supply systems for public and private transport systems. The system provides purified air supply for travelers in the closed environment such as in a airplane, or on a train against various dangerous viruses including COVID-19 and SARS virus. It can also be used in office during flu season as well as provide cleaned air supply to its users against the hay-fever.

Abstract: A system includes an air duct and an ultra-violet (UV) photocatalysis system in fluid communication with the air duct for reduction of airborne pathogens in air flow through the air duct. An HVAC system can is fluid communication with the air duct, where the HVAC system is upstream and/or downstream of the air duct. The UV photocatalysis system can include at least one vacuum UV (VUV) illuminator positioned in the air duct to illuminate at least one photocatalyst body. The photocatalyst body can be configured to catalyze ionization of pathogens in airflow through the air duct under illumination from the VUV illuminator.

Abstract: Provided is an indoor air cleaning device for a vehicle using a nonthermal plasma and an operation method thereof, and more particularly, to an indoor air cleaning device for a vehicle using a nonthermal plasma, in which ozone is generated by a nonthermal plasma through corona discharge and an air purifying filter is sterilized through strong oxidization action of ozone, achieving more hygienic and continuous management, static electricity of an electrostatic filter is recharged with the controlled magnitude of applied voltage to maintain the best purification performance of the filter, and negative ions beneficial for human body are generated, creating pleasant indoor air conditions.

Abstract: The present invention is directed to an absorbable hemostatic patch that utilizes a biocompatible fibrous, fabric substrate that is melt-blown and napped or loosened at the surface, with the substrate having a low-profile, high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ultimately effective for use as a hemostat in situations of problematic bleeding.

Abstract: A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.

Abstract: The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.

Abstract: Spray-dried thrombin materials obtained from feedstock solutions comprising less than 5% by weight albumin and excluding trehalose or other excipients as well as methods of manufacturing the thrombin materials and methods of treating bleeding wounds are disclosed. The methods of use include applying reconstituted spray-dried thrombin topically to a bleeding site, optionally in conjunction with gelatin.

Abstract: The invention relates to a functional wound dressing being able to provide substances supporting the healing of a wound to the wound depending on the condition of the wound. In particular, in case of an infection which is reported to be frequently associated with poorly healing wounds, such as chronic wounds, a therapeutic substance is provided to the wound whereas in other cases no therapeutic substance is provided. The present wound dressing can be used in moist wound healing and contains a substance being able to absorb wound exudate from the wound and to provide moisture to the wound.

Abstract: Compositions and blends of biopolymers and copolymers are described, along with their use to prepare biocompatible scaffolds and surgically implantable devices for use in supporting and facilitating the repair of soft tissue injuries.

Abstract: The present invention provides an artificial bionic blood vessel and a manufacturing method thereof. The artificial bionic blood vessel includes a three-layer-structured artificial bionic blood vessel body, where the three-layer structure of the artificial bionic blood vessel consists of a natural silk layer, a diluted liquid silica-gel layer and a weaved tube layer, the diluted liquid silica-gel layer is located on the inner side of the natural silk layer, the weaved tube layer is located on the outer side of the natural silk layer, and the weaved tube layer is made of catgut by weaving.

Abstract: Disclosed are a sustained-release injection formulation containing a biodegradable polymer microcapsule that contains a conjugate of poly-L-lactic acid (hereinafter referred to as “PLLA”) filler and hyaluronic acid (hereinafter referred to as “HA”) and contains a PLLA-HA microcapsule, and a method of preparing the same.

Abstract: Compositions and methods for their manufacture and use are provided comprising a soluble extracellular matrix fraction for intravascular delivery which forms a gel or coating in situ for treatment of myocardial infarction and ischemia in a variety of tissues and endothelial injury/dysfunction.

Abstract: This disclosure describes methods of preparing a decellularized Descemet's membrane and an isolated Descemet's membrane, methods of using an isolated Descemet's membrane, and tissues prepared using an isolated Descemet's membrane. This disclosure further describes a composition that includes an isolated Descemet's membrane. In some embodiments, the tissues and methods described herein may be used to treat a limbal stem cell deficiency or as an ocular surface bandage.

Abstract: A device for mechanical fragmentation of tissues facilitates preparation of the composition of isolated cells from a tissue sample, the preparation including mechanical fragmentation of the tissue, the device including a motorized support and a container, the motorized support including a motor having a rotor secured to a coupling member, the container internally including a rotary shaft with radial arms sweeping the inside of the container as the shaft rotates, the motorized support and the container including a complementary securing unit that allow the container to be immobilized on the motorized support, the coupling member and the rotary shaft being configured in such a way as to allow axial rotation of the rotary shaft when the rotor of the motor is turning. The radial arms are of two types: rigid vane-type arms, and flexible filamentary-type arms, notably made of nylon or of metal. A corresponding method is also disclosed.

Abstract: A method includes covering or contacting a portion of a recurrent laryngeal nerve of a subject with a shield including extraembryonic tissue. The covering occurs during a neck or reconstructive surgery of the subject.

Abstract: A biodegradable and biocompatible barrier membrane of piezoelectric nano composites of Metallic Oxide (MO) (e.g., Magnesium oxide, Zinc oxide and iron oxide)-PLLA (Poly-L-lactide), which can be subjected to acoustic pressure from ultrasound, to generate useful electrical charge for enhanced bone regeneration and enhanced antibacterial effects for guided bone regeneration to treat dental diseases, such as periodontitis.

Abstract: A method for manufacturing a medical instrument having a lubricating layer (coating layer) that exhibits excellent durability (particularly, sliding durability) is provided. The method for manufacturing a medical instrument is a method for manufacturing a medical instrument that includes a base layer and a lubricating layer carried on at least a portion of the base layer. The method includes applying a solution including a block copolymer having a structural unit derived from a reactive monomer having an epoxy group and a structural unit derived from a hydrophilic monomer, a choline derivative, and a solvent, on the base layer.

Abstract: Disclosed herein is a biomaterial and a method of use thereof for treating a condition. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer.

Abstract: A tubular nonwoven structure as an active agent carrier (“sleeve”) for the atraumatic treatment of hollow organs, in particular applicable via a balloon catheter, as well as a method for the production thereof, wherein the sleeve is folded about a longitudinal sleeve axis in an initial state and is unfoldable in a final state for attachment to an inner wall of a hollow organ, the tubular sleeve is formed of first biodegradable polymer nanofibers and the folding of the sleeve is directed as pleating about a longitudinal sleeve axis, a medicinal active agent is incorporated into the first polymer nanofibers and/or is arranged in interspaces between the polymer nanofibers, and the first polymer fibers are formed such that the polymer fibers degrade over a period of 2 weeks to 3 months so that the active agent can be delivered to a hollow organ wall in this period of time.

Abstract: There is provided inter alia an anticoagulant surface which surface has covalently bound thereto a plurality of fragments of heparin, wherein said fragments consist of 5-18 saccharide units and at least some of said plurality of fragments comprise polysaccharide sequence A, which surface catalyses the inhibition of FIIa and FXa by AT.

Abstract: Devices and methods for controlling intracompartmental pressure in muscle compartments and, potentially, reducing the incidence of compartment syndrome are disclosed. A device according the invention is a thin, elongate member with an outer layer. The device has a proximal end, which has a coupling constructed and adapted to connect with tubing, and a distal end. The outer layer is at least somewhat permeable to liquids and to cells, either by way of perforations along its length or because of its natural properties. Within and encased by the outer layer lies a core, also porous, and typically an open-celled foam. The core is compressible under the range of suction pressures typically applied in medical contexts. A guide wire may initially be present in the device to aid in its placement. Methods for making such devices, especially on an ad hoc basis, are also disclosed.

Abstract: A wound treatment apparatus is provided for treating tissue damage, which comprises a fluid impermeable wound cover sealed over a site for purposes of applying a reduced pressure to the site. The apparatus also can include a cover with protrusions on its surface for purposes of monitoring pressure at the site. One or more sensors can be positioned under the cover to provide feedback to a suction pump controller. The apparatus can have a miniature and portable vacuum source connected to the wound cover.

Abstract: The present invention relates generally to the field of cardiac, vascular system, and heart assistance devices. It provides the energy required to keep the blood flowing in the pulmonary and systemic circuits to a desired level, acting on one or more chambers. Actual problems of Total Artificial Heart pumping blood are design limitations, infection, hemorrhage, end organ failure, thromboembolism, device disfunction, life span of diaphragms, and impossibility to restore the heart but with a transplant. The device is external and has four units replicating the natural heart and its dynamics, driving by a pneumatic transcutaneous system to provide the energy needed up to the desired working level of a healthy organ. Applications are on those types of surgical or clinical treatment of patients with Diastolic Heart Failure or used to treat Heart Failure with Reduced Ejection Fraction (Systolic Heart Failure), the device can be left connected permanently of for healing.