Abstract: A fluid warming device for an extracorporeal blood treatment apparatus, comprises: an outlet temperature sensor (31) operatively active at an outlet (22) of a fluid warming path (23) to detect a measured outlet temperature (To) of a fluid leaving the fluid warming device (18); an electronic control unit (29) operatively connected to the outlet temperature sensor (31). The electronic control unit (29) is configured to perform the following procedure: receiving, from the outlet temperature sensor (31) a signal correlated to a measured outlet temperature (To); correcting the measured outlet temperature (To) through a correction model to obtain an actual fluid outlet temperature (Tout); adjusting a heating power (Ph) of heating elements to keep the actual fluid outlet temperature (Tout) at a set reference temperature value (Tset).

Abstract: The invention concerns a control or regulating device with a control or regulating unit, which both controls or regulates a volumetric blood flow flowing through a blood pump as well as a volumetric flow of a gas able to flow through a gas exchange unit.

Abstract: A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a control unit configured to operate in a hybrid automated mode during a PD treatment. A processor in the control unit is configured to engage a pump during a fill phase of the PD cycle. The volume of fluid (e.g., dialysate) transferred to a patient line during the fill phase is monitored. After a dwell period, the pump is disengaged at the start of a drain phase of the PD cycle. Disengaging the pump can include: configuring valves of a disposable cassette to bypass the pump chambers of a disposable cassette; activating a bypass valve to shunt the patient line to a drain line; or moving a roller assembly of a peristaltic pump. The fluid transferred from the patient line to the drain line is monitored during the drain phase of the PD cycle.

Abstract: A treatment device system includes a treatment machine for performing a therapy on a patient, the treatment machine including at least one fluid conveyor and a controller, the controller having a first memory, to cause the at least one fluid conveyor to produce a therapeutic fluid by mixing purified water and at least one concentrate. The system also includes and a water purifier in fluid communication with and providing the purified water to the treatment machine. A wired or wireless control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier, wherein the controller of the treatment machine transmits data via the control line to the internal central controller of the water purifier for control of the water purifier, the data provided based on at least one of the operator inputs received via the user interface.

Abstract: A treatment device system includes a treatment machine for generating custom peritoneal dialysis solution and including at least one fluid conveyor, the treatment machine having a controller, the controller having a first memory, configured to produce a therapeutic fluid by causing the at least one fluid conveyor to mix purified water and at least one concentrate. The system also includes a user interface and a water purifier in fluid communication with and providing the purified water to the treatment machine, the water purifier including internal central controller, the internal central controller having a second memory, to control preparation of the purified water. A server is communicatively coupled with the treatment machine and a control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier.

Abstract: A blood filtration system may to couple to an infusion pump that is external to the blood filtration system. The blood filtration system may include a blood circuit, for instance a variable-volume blood circuit. An infusion port may be in communication with the blood circuit and may receive an infusion fluid pumped by the infusion pump. A filtration pump may extract a filtrate fluid from a filter. The filtrate fluid may include filtered plasma constituents. A fluid characteristic sensor may measure one or more of pressure or flow rate of the infusion fluid pumped by the infusion pump. A controller may monitor the fluid characteristic sensor to determine a change in the pressure or flow rate of the infusion fluid. The controller may modulate a speed of the variable-speed filtration pump based on the change in the pressure or flow rate of the infusion fluid.

Abstract: The present disclosure is directed to methods of removing proteins, including cytokines, from blood and blood products, the methods comprising contacting the blood or blood product with a form of carbon having high graphitic contents and slit-shaped mesopores and macropores, the pore size dimensions chosen to be comparable to the size of the proteins, wherein the contacting results in the removal of high levels of the protein from the blood or blood product in minutes or hours.

Abstract: A blood filtration system can reduce the amount of plasma constituents (e.g., water and/or electrolytes) in the blood of the patient, and accordingly increase the hematocrit value of the patient. The blood filtration system (e.g., a controller, or the like) can determine a hematocrit value of a patient. The blood filtration system can determine a venous pressure of vasculature of a patient. The blood filtration system can compensate for pressure head in a component of a blood circuit (e.g., a withdrawal line of a catheter), for example to improve the accuracy of the venous pressure determination. The blood filtration system can determine one or more resistance characteristics of a blood circuit for the blood filtration system. The resistance characteristics can correspond to a resistance to a flow of blood through a component of the blood circuit.

Abstract: Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed.

Abstract: An extracorporeal blood treatment apparatus, comprises: at least a pressure sensor (24,25) located in a respective measurement site on an extracorporeal blood circuit (6, 7); an electronic control unit (23) operatively connected at least to the pressure sensor (24, 25). The electronic control unit (23) is configured to perform at least the following procedure: receiving from the pressure sensor (24, 25) a signal correlated to a measured blood pressure (P1measured, P2measured) in the measurement site; correcting the blood measured pressure (P1measured, P2measured) through a mathematical correction model to obtain a blood actual pressure (Pinlet, Poutlet) in a reference site other than the measurement site. Between the reference site and the measurement site, a circuit section and, optionally, at least one additional device (18, 27, 28) is/are positioned. The mathematical correction model is a model of a pressure drop in the circuit section and, optionally, in the additional device (18, 27, 28).

Abstract: Systems and methods used to detect blood leaks (in, for example, extracorporeal blood treatment apparatus) by detecting the presence of blood in liquid above a selected threshold amount based on the flow rate of the liquid flowing through a passage (for example, a tube, etc.) are described.

Abstract: A system, device, and autologous method for treating blood. Blood is extracted from a patient. The blood is tested to determine one or more pathogens and conditions of the blood. One or more catalysts are automatically added into the blood of the patient. The one or more catalysts are activated utilizing the one or more emitters configured to interact with the one or more catalysts in the blood create treated blood. One or more additives are added into the threated blood. The treated blood is reinjected into the patient.

Abstract: Embodiments disclosed herein are directed to apparatus and methods for a fluid collection system and automated fluid flow monitoring. The system can include a collection container, and a detection device coupled to an outside surface thereof and configured to detect a volume of fluid disposed therein. The detection device can be coupled to the collection container without having to compromise the integrity of the closed fluid collection system or re-catheterizing the patient. The detection device can be configured to detect an inversion event, tilt event, and the like to determine a flow rate of fluid into the container. The detection device can be communicatively coupled with external computing devices to alert a clinician when the container is nearing capacity and when it has been emptied.

Abstract: A declogging assembly (20) is configured for use with a suction conduit (10). The suction conduit has a head (14) at a first end (15) and a vacuum tube connection (16) at a second end (17). The assembly includes a body (30). The body defines a first aperture (32), a second aperture (34), and a third aperture (36). The assembly also includes a plug (40) disposed within the body (30). The plug has a surface (42) configured to contact the head (14) of the suction conduit (10) so as to move the plug from a first position, in which the first aperture (32) is in fluid communication with the second aperture (34), to a second position, in which the first aperture (32) is in fluid communication with the third aperture (36). The assembly (20) also includes a biasing member (50) configured to bias the plug into the first position.

Abstract: A chemical pump assembly useful for negative pressure therapy includes a chemical pump housing having an inner chamber, a reactor located within the inner chamber, an opening provided in the chemical pump housing, a first pull tab which extends from the inner chamber to ambient through the opening, and a removable layer connected to the first pull tab. The reactor is configured to react with a selected gas found in air so as to consume the selected gas when exposed to air in the inner chamber. The removable layer shields the reactor from air in the inner chamber atmosphere until the removable layer is removed.

Abstract: Embodiments of delivering reduced pressure wound therapy are disclosed. In some embodiments, a system includes a reduced pressure wound therapy device and a remote computer. The device can be configured to apply reduced pressure to a wound of a patient according to a default reduced pressure therapy prescription. The device can be configured to monitor usage data and transmit the usage data to the remove computer for determining compliance with a reduced therapy prescription. In some cases, non-compliance can be determined due to change of the prescription from the default prescription to a prescription more suitable for treating the wound. A non-compliance notification can be transmitted to the device. The device settings can be updated to the current prescription.

Abstract: An evaporative bridge dressing that may be used with negative-pressure treatment of tissue. The evaporative bridge dressing may have one or more fluid transfer layers comprised of high-density wicking material enclosed between layers of film having high moisture-vapor transfer rates to manage liquid storage and pressure drop. The evaporative bridge may have an absorbent in some embodiments. An evaporation channel may be disposed adjacent to or combined with the evaporative bridge. A means for measuring pressure across the evaporative bridge may include a feedback path. A support means may reduce or prevent collapse of one or more of the evaporative bridge, the evaporation channel, the feedback path.

Abstract: A negative pressure device for applying to skin is configured to define a sealed enclosed three-dimensional space when at least a portion of the device is sealed against the skin. The device includes a body including at least one expandable segment that is configured to expand after the device has been sealed against the skin.

Abstract: A synchronized automated bronchial lavage aspiration apparatus synchronizes with ventilator inspiration and expiration cycles to clear a patient's airway of stagnant secretion automatically. Synchronized and automatic instillation of saline prior to aspiration suppresses bacteria in the airway and suctioning during exhalation drains the airway of sputum.

Abstract: A system for treating internal bleeding via application of a heated irrigant, such that the heated irrigant is delivered at a flow rate of between 2 cc/s and 12 cc/s and at a temperature of between 46 degrees Celsius and 52 degrees Celsius.

Abstract: A hand-held personal hygiene device includes a main body having an upper end, a lower end, and a pump therein. The pump is configured to pump water or another fluid from an inlet port at the upper end to an outlet port at the lower end. A reservoir has a lower base configured to removably seat in the upper end of the main body to engage and open a self-closing valve with the inlet port of the main body. A tubular nozzle member has a lower end comprising one or more nozzle outlets and an upper end configured to be removably secured to the outlet port of the main body causing liquid pumped by the pump to flow through the tubular nozzle member to the one or more nozzle outlets. The reservoir and the main body may be aligned to form a liquid flow path that may be held vertically to allow gravity flow from the reservoir to the pump.

Abstract: A syringe holder for holding and stabilizing syringes, the syringe holder comprising a base, and both a vertical mount and a horizontal mount extending from one side of the base. The vertical mount comprises a cylindrical cavity configured to receive and rotatably attach the syringe to the base such that the syringe is held to the base in a generally vertical orientation, while the horizontal mount comprises a lower barrel support and an upper barrel support configured to receive and rotatably attach the bottom end of the barrel and the top end of the barrel of the syringe to the base such that the syringe is held to the base in a generally horizontal orientation. In both orientations, the syringe holder of the present invention provides easy access to most of the exterior surfaces of the syringes and reduces safety hazards associated with creating sample defects on syringes for purposes of qualification testing for syringe inspectors.

Abstract: A syringe rack securable to a surface of a fixture and configured for facilitating a sterile transfer of fluid from a non-sterile environment to a sterile environment. The syringe rack includes a securing portion and a syringe-receiving station. The syringe-receiving portion is coupled to the securing portion and configured to receive the syringe in a selectively releasable coupling arrangement where the syringe is oriented such that an opening in a barrel of a syringe projects away from the fixture when the syringe is received by the syringe-receiving station and when the securing portion is secured to the surface of the fixture.

Abstract: Some embodiments of an infusion pump system may be configured to wirelessly communicate with other devices using near field communication (NFC). In particular embodiments, by incorporating near field communication capabilities into the infusion pump system, user communications with the infusion pump system can be enhanced and simplified.

Abstract: A system and method is provided for detecting fluid low-volume and occlusion in a device using force sensing resistor (FSR) sensor. One or more force sensing resistors are positioned in communication with a fluid channel at one or more of a pump intake and pump outlet to detect pressure in the fluid channel. The pressure is detected through communication with the force sensing resistor and indicates an irregular system condition including but not limited to, fluid low-volume level and occlusion. Also provided are a fluid flow sensor (e.g., FSR or MEMS sensor) disposed relative to an embedded fluid channel in the base of a wearable medicine delivery pump.

Abstract: Systems and methods for automatically delivering medication to a user. An automated drug delivery system may include a sensor and a wearable automated drug delivery device. The wearable automated drug delivery device may be configured to couple to the skin of a user and may include a controller and a pump. The pump may be configured to output the medication. The controller may be within the wearable automated drug delivery device. The sensor may be coupled to the user and may be configured to collect information regarding the user. The controller of the wearable automated drug delivery device may use the collected information to locally determine an amount of medication to be output from the wearable automated drug delivery device and cause delivery of the amount of medication.

Abstract: A remote delivery device is provided which has media portholes in a sidewall, a tail piece attached to a rear end and a cannula attached to a front end. The body contains a plunger assembly which defines an injectable liquid chamber and a marking media chamber. The plunger assembly includes a front barbell plunger, rear barbell plunger and a plunger shaft with an O-Ring seated between the front and rear of said plunger shaft. The body also contains a single internal charge positioned behind the plunger assembly. When the charge is activated, the plunger assembly is thrust forwardly and dispenses an injectable liquid from the injectable liquid chamber through the cannula. Simultaneously, the plunger assembly also dispenses a marking media from the marking media chamber through marking media portholes. The provision of a single internal charge allows for a reduction in the length and weight of the device.

Abstract: A syringe with an injection dose adjustment function, comprising a medicine vial connecting apparatus and an adjustable propulsion apparatus; by means of assembling the medicine vial connecting apparatus and a medicine vial, and then installing the adjustable propulsion apparatus in the medicine vial connecting apparatus and extending same into the medicine vial, a rotating knob of the medicine vial connecting apparatus can drive a push rod of the adjustable propulsion apparatus to move backward to a predetermined scale; at the time of injection, pressing the push rod enables the medicine vial to output a predetermined dosage of medicinal liquid, such that the syringe can adjust the injection dosage according to the requirements of different injection subjects.

Abstract: A deformable cartridge for an injection device of an injectable solution has a cartridge body having a first containment chamber of a first component of the injectable solution, having a first compression-deformable wall, a second containment chamber of a second component of the injectable solution, having a second compression-deformable wall to allow the second component to be transferred from the second containment chamber to the first containment chamber, a separation device interposed between the first and the second containment chambers and having a device body. A fluidic communication duct is defined in the device body. The deformable cartridge assumes a first operating configuration in which the fluidic communication duct is not crossable by the second component and a second operating configuration in which the fluidic communication duct is crossable by the second component.

Abstract: A storage case for musical accessories includes a compartment comprising a sidewall and a bottom wall, the sidewall defining a top end and a bottom end, the bottom wall coupled to the bottom end of the sidewall, the top end of the sidewall defining a compartment opening; and a substantially cylindrical accessory mount extending from the bottom wall towards the opening, the accessory mount extending substantially parallel to the sidewall, the accessory mount configured to receive a cylindrical musical accessory placed over and around the accessory mount.

Abstract: A medicament packaging assembly for installation in a medicament delivery device is disclosed. The packaging assembly comprises a cartridge having a medicament chamber, a sealing element for sealing a distal end of the medicament chamber, a sealing element release member, a cannula and a removable cap member. The assembly is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula.

Abstract: A syringe exostructure includes a main body which removably receives a syringe having a syringe barrel and a syringe plunger. A drive plunger is reciprocatably mounted on the main body, and a plunger bar is slidably received in an axial channel on the drive plunger. The plunger bar is configured to removably couple to the syringe plunger when the syringe is introduced into the main body. A drive pawl assembly is fixed to an upper surface of the drive plunger and transfers forward motion of the drive plunger to the plunger bar as the drive plunger is advanced and disengages from the plunger bar when the drive plunger is retracted. A locking pawl assembly is fixed to the main body and extends through a slot formed in the bottom of the axial channel in the drive plunger. The locking pawl engages the plunger bar and allows the plunger bar to be advanced by the drive plunger as the drive plunger is advanced but prevents the plunger bar from being retracted by the drive plunger as the drive plunger is retracted.

Abstract: A medication delivery device usable with a medication container wherein advancement of a piston within the container expels medication. The device includes a housing and a drive assembly. The drive assembly includes a drive ribbon having distal and proximal edge sections. The drive ribbon has a retracted configuration defining a spiral and an extended configuration defining a helix. The drive ribbon is movable from the retracted configuration to the extended configuration with such movement defining a drive axis and advancing the piston. In some embodiments, the drive ribbon may not rotate as it is advanced while in other embodiments, the ribbon does rotate. The disclosed drive assemblies include manually driven assemblies, spring driven assemblies and motor driven assemblies. The containers may be replaceable to allow for reuse of the device. In some embodiments, replaceable cartridges which includes both a medication container and a drive ribbon are employed.

Abstract: A syringe includes a barrel, a plunger, and a sealing member creating a seal between the plunger and the barrel. The barrel includes a first portion with a first inner diameter and a second portion with a second inner diameter that is larger than the first inner diameter. The sealing member engages the first portion of the barrel to give rise to a first contact pressure when the barrel is filled with product. The first contact pressure is sufficient to maintain a gas-tight seal over the expected temperature ranges ?25° C. to 40° C. A first force is applied to the plunger to overcome the first contact pressure and move the plunger out of the first portion and into the second portion to dispense product. The sealing member engages the second portion of the barrel to give rise to a second contact pressure that is lower than the first contact pressure.

Abstract: A kit is disclosed for accurately loading a small volume dose of a medication within a syringe and for delivering the small volume dose of the medication at a treatment site. The kit generally includes a loading and delivery system in accordance herewith, a syringe, and a medication. The loading and delivery system includes a syringe delivery ring and a syringe loading guide, which may be used for example, to administer a small volume dose of a medication at the end of an ocular surgery.

Abstract: The disclosure relates to a parenteral injection apparatus that guides a needle of an injector into a target site to deliver medicaments and other fluids.

Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.

Abstract: The disclosure relates to a needle cover for protecting a needle mounted on a tip of a medical injection device. The tip comprises a distal bulge. The needle cover comprises an inner needle shield made of a material with elastomeric properties. The inner needle shield comprises an inner sealing portion configured to sealingly contact the outer surface of the bulge, wherein the inner sealing portion comprises one or more ribs extending inwardly along the circumference of the inner sealing portion. At least one rib is a continuous rib in the form of a ring configured to provide a continuous contact with the outer surface of the bulge.

Abstract: Disclosed herein is a fluid dispenser comprising a barrel defining a longitudinal axis terminating at a first fluid delivery end region; a body movable along the barrel relative to the first fluid delivery end region, the body including a needle carrier, a plunger and a capsule carrier therebetween, a latch interface between the body and the barrel and responsive to a release force therebetween caused by compressive engagement of the barrel at a fluid delivery site on a patient, to enable travel of the plunger and capsule carrier toward the needle carrier, to a dispensing configuration in which an upstream end of the needle pierces the capsule and projects form the first fluid delivery end region to deliver a fluid to the fluid delivery site.

Abstract: An apparatus for use with a syringe to provide a safety syringe, the apparatus comprising: a sheath (100; 300; 500; 700; 900; 1100; 1300) deployable for at least partially covering a needle of the syringe; a sheath actuator (102; 302; 502; 702; 902; 1102; 1302) for deploying the sheath; and a ratioed mechanism (104; 304; 504; 704; 904; 1104; 1304) linking the sheath and the sheath actuator and configured such that a magnitude of movement of the sheath is greater than a magnitude of movement of the sheath actuator during deployment of the sheath.

Abstract: The present invention provides a needle unit (10) for use with a pen injection device, wherein the needle unit (10) comprises a needle shield (50) and an axially movable needle hub (25).

Abstract: A channel for a medicinal liquid is formed in a filter-integrated medicine transfer device according to an embodiment of the present disclosure. The filter-integrated medicine transfer device includes: a housing having an air passage that diverges from a medicinal liquid channel and is connected to outside; at least one hydrophobic air-passing filter disposed in the housing and disposed at a boundary between the air passage and the medicinal liquid channel; and at least one medicine transfer pipe disposed in the housing and having a capillary channel constituting a portion of the medicinal liquid channel.

Abstract: An infusion pump system is disclosed. The infusion pump system includes an infusion pump and a controller device in wireless communication with the infusion pump, wherein the controller including instructions for controlling the infusion pump, wherein the instructions may be synchronized with a secure web portal.

Abstract: A portable inhalation device includes a medication storage component, a flow controller, an atomizer, a medication delivery component, and a pressure sensor. The medication storage component is configured to store medication. The flow controller is configured to cause a force to be applied to the medication stored by the medication storage component to transport the medication to the atomizer. The atomizer is configured to generate droplets from the medication. The medication delivery component includes a delivery channel extending from the atomizer to an outlet opening. The medication delivery component is configured to receive the medication in the delivery channel from the atomizer and dispense the medication via the opening. The pressure sensor is configured to detect a pressure corresponding to a flow rate of air in the delivery channel and output an indication of the detected pressure.

Abstract: The present disclosure is a handheld apparatus that vaporizes plant-based or synthetic compounds, for the purpose of inhalation, or diffusion into an external environment. More specifically, the disclosure describes a handheld apparatus wherein a laser beam from an internal laser unit heats compounds, such as dried plant, tinctures, resins, or essential oils, to the compound's vaporization temperature for inhalation, or diffusion as part of aromatherapy or other holistic therapeutic treatments.

Abstract: The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. In one example, the system comprises a container for holding the therapeutic agent, and a pressure source having pressurized fluid, wherein the pressure source is in selective fluid communication with at least a portion of the container. A catheter is placed in fluid communication with the container, and has a lumen sized for delivery of the therapeutic agent to a target site. A housing is configured to securely retain the container. The system further comprises a camera having a camera head coupled to the catheter, wherein the camera provides a visual image of the target site during delivery of the therapeutic agent.

Abstract: The method includes first providing a retention medium in a first element; coaxially aligning a plurality of elements, wrapping the coaxially aligned plurality of elements within a wrapper to form a portion of the aerosol-generating article, the plurality of elements including the first element, the aerosol-generating article having a first end and a second end, the second end being upstream from the first end based on an expected direction of airflow through the aerosol-generating article during normal operational use, second providing at least one capsule, the at least one capsule releasably containing a substrate, and inserting the at least one capsule within the first element, the retention medium being configured to retain the substrate after a release of the substrate from the at least one capsule, the retention medium being devoid of the substrate prior to the release of the substrate from the at least one capsule.

Abstract: The present invention provides a dry powder inhaler comprising: a reservoir containing a dry powder formulation and an arrangement for delivering a metered dose of the medicament from the reservoir; a cyclone deagglomerator for breaking up agglomerates of the dry powder medicament; and a delivery passageway for directing an inhalation-induced air flow through a mouthpiece, the delivery passageway extending to the metered dose of medicament, wherein the formulation comprises an inhalable ?2-agonist having a particle size distribution of d1O<1 ???=1-3 ???, d90=3.5-6 ?m and NLT 99% 10 ?m and a lactose carrier.

Abstract: A flow generator is configured to pressurize a flow of breathable gas to within a range of about 2-30 cm H2O for delivery to a patient's airways. The flow generator includes a blower with at least one impeller and a motor configured to drive the at least one impeller. The flow generator also includes a substantially planar blower mount configured to support the blower. The blower mount includes a flexible blower receptacle portion configured to receive and support the blower. The blower receptacle portion includes an outlet opening that is axially aligned with an air outlet of the blower. The flow generator also includes housing that encloses the blower and the blower mount. The housing has an inner surface that engages a perimeter of the blower mount.

Abstract: A ventilation therapy apparatus and a control method, includes: an apparatus body, a respiratory pipe and a patient interface. The apparatus body further includes: a signal acquisition module, a target pressure acquisition module and a first control module. The signal acquisition module is configured for acquiring an output pressure value and an output flow value of a signal collection point of the apparatus body; the target pressure acquisition module is configured for acquiring a target pressure value at the patient interface; the first calculation module is configured for, calculating an actual pressure value at the patient interface according to the output pressure value and the output flow value of the signal collection point; the first control module is configured for adjusting an output flow of the apparatus body according to the actual pressure value and the target pressure value.