Abstract: A monitoring system includes a first acquisition unit that acquires identification information unique to a user, a second acquisition unit that acquires position information of the user, an action history calculation unit that obtains an action history of the user from the identification information of the user acquired by the first acquisition unit and the position information acquired by the second acquisition unit, and a presentation unit that presents the action history of the user calculated by the action history calculation unit, wherein the action history includes at least one of a period for which and a frequency at which the user stayed at a position indicated by the position information.

Abstract: Present invention provide a system and a method for recording, evaluating, screening and monitoring life style associated Non-communicable diseases related data of a subject via an Integrated Medical Device (IMD) in real time, and sharing the same on a server, either local or cloud based, for fast, active sharing of data by remote users anytime anywhere.

Abstract: An electronic device is provided. The electronic device includes a communication module, a display, a memory, a biosensor configured to measure oxygen saturation, and at least one processor. The at least one processor may be configured to obtain electronic medical record (EMR) data from an external server through the communication module, identify oxygen saturation-related medical records based on the EMR data, based on occurrence of an event, determine a specified oxygen saturation measurement period and a specified reference oxygen saturation range based on the oxygen saturation-related medical records, measure oxygen saturation based on the specified oxygen saturation measurement period by using the biosensor, identify whether the measured oxygen saturation satisfies the specified reference oxygen saturation range, and display the measured oxygen saturation and information indicating whether the measured oxygen saturation satisfies the specified reference oxygen saturation range on the display.

Abstract: A system for performing a minimally invasive procedure comprises a flexible catheter with a lumen extending therethrough. The system also comprises an elongate instrument sized for passage through the lumen and an optical coherence tomographic sensor coupled to the elongate instrument. The system also comprises a control system that includes one or more processors. The control system is configured to receive sensor data from the optical coherence tomographic sensor, profile a tissue based on the received sensor data, generate an output signal based on the profiled tissue, and based on receipt of the output signal, generate a command to indicate or affect movement of the elongate instrument.

Abstract: Methods and apparatus for predicting performance of an individual on a task, the method comprises receiving brain imaging data for the individual, wherein the brain imaging data comprises structural brain data, determining values for at least one characteristic of the structural brain data within regions of interest defined for a population of individuals having different performance levels, and predicting based on the determined values, a performance potential of the individual.

Abstract: A system for outputting a representation of a wound in tissue comprises a housing configured to removably receive at least a portion of a wireless communication device. At least one light source coupled to the housing is configured to emit excitation light to illuminate a target which includes at least a portion of the wound. A power supply contained in the housing is configured to provide power to the light source. A non-transitory computer-readable medium stores a program executable to cause the performance of operations comprising detecting signals responsive to illumination of the target, outputting the representation of the target based thereon, storing data relative to one or more target surface parameter based on the detected signals, and displaying the representation. The signals correspond to at least one of endogenous or exogeneous fluorescence, absorbance, and reflectance from at least one biological component in and/or on the target.

Abstract: A system for generating hyperspectral imaging data for measuring biochemical compositions is disclosed which includes a spectral imaging device adapted to acquire one or more hyperspectral linescan images, an optical imaging device with a red-green-blue (RGB) sensor adapted to acquire an RGB dataset, a processor adapted to co-locate a plurality of pixels in the RGB dataset vs. a corresponding plurality of pixels of the one or more hyperspectral linescan datasets, establish a transformation matrix utilizing the plurality of co-located pixels, apply the transformation matrix to the RGB dataset to thereby generate the hyperspectral dataset, and analyze the generated hyperspectral image dataset to determine the biochemical compositions.

Abstract: The present technology relates to the field of medical monitoring. Patient monitoring systems and associated devices, methods, and computer readable media are described. In some embodiments, a patient monitoring system includes one or more sensors configured to capture first data related to a patient and a monitoring device configured to receive the first data. In these and other embodiments, the patient monitoring system can include an image capture device configured to capture second data related to the patient. In these and still other embodiments, the one or more sensors can be configured to instruct the patient monitoring system to display the second data.

Abstract: A system may comprise a first catheter having a first steerable segment and a second catheter disposed within the first catheter. The second catheter may have a second steerable segment. The system may also comprise an imaging element supported at a distal end of the second catheter, a coil reference sensor supported at a distal portion of the second catheter, and a processor in electrical communication with the coil reference sensor. The processor may be configured to determine a position of a distal portion of the first catheter with reference to the coil reference sensor.

Abstract: A device for measuring a temperature at one or more locations in an organ or tissue inside the human or animal body, a related kit and a related method. The device includes a catheter tube having a distal end for inserting into the body and a proximal end for remaining outside the body in use of the device, and at least one resistive temperature sensor in the tube, and a plurality of electrical wires in the tube that are connected to the at least one resistive temperature sensor. The plurality of electrical wires includes at least some electrical wires running from the proximal end of the tube through the tube. The device includes a connector at the proximal end of the tube for electrically connecting the plurality of electrical wires to an external device. The resistive temperature sensor includes a thermal resistor and a first terminal and a second terminal.

Abstract: Disclosed are devices, systems, and methods for determining the dipole densities on heart walls. In particular, a triangularization of the heart wall is performed in which the dipole density of each of multiple regions correlate to the potential measured at various located within the associated chamber of the heart. To create a database of dipole densities, mapping information recorded by multiple electrodes located on one or more catheters and anatomical information is used. In addition, skin electrodes may be implemented. Additionally, one or more ultrasound elements are provided, such as on a clamp assembly or integral to a mapping electrode, to produce real time images of device components and surrounding structures.

Abstract: A cardiopulmonary resuscitation (CPR) cerebral monitoring device including a measurement probe having one or more optical emitters, and one or more optical detectors, and including an optical instrument having an optical source, and an optical detector. Also included is a controller configured to control the optical instrument to emit multi-spectral light through the one or more optical emitters to illuminate a tissue, control the optical detector to detect multi-spectral light emitted from the illuminated tissue, compare the emitted multi-spectral light to the detected multi-spectral light, compute a plurality of cerebral tissue parameters based on the comparison, determine CPR procedures based on the plurality of cerebral tissue parameters, and control a user output device to instruct a user to perform the CPR procedures, and/or control an automated CPR device to perform the CPR procedures.

Abstract: A cardiovascular detection system and method, comprising an active compression cuff contracting at a frequency higher than the systolic frequency of the heart. Meanwhile, the detection device is used to capture the influence of the active compression cuff and cardiac systole on the blood of the part to be detected. In addition, it is supplemented by electrocardiography to monitor the reference value of cardiac systole to distinguish the difference between the pulse wave generated by the active compression cuff and the pulse wave generated by the heart. In this way, the state of the cardiovascular system can be quickly understood. Since the active compression cuff is contracted at a frequency higher than the systolic frequency of the heart, it can be more accurately determined whether the blood vessel is blocked or hardened.

Abstract: Methods and systems are provided for assessing a vasculature of an individual. In an embodiment of a method, one or more angiographic parametric imaging (API) maps of the vasculature are obtained, wherein each API map of the one or more API maps encodes a hemodynamic parameter. A state of the vasculature is determined using a machine-learning classifier applied to the one or more API maps.

Abstract: A fluid circuit of a blood pressure measurement device includes a first cuff connected to a secondary side of a pump that supplies a fluid to the secondary side, a first fluid resistor connected to a secondary side of the first cuff, a second fluid resistor provided on a secondary side of the first fluid resistor and connected to an atmosphere, and a second cuff provided between the first fluid resistor and the second fluid resistor.

Abstract: A method of estimating a value associated with heart wall tension. The method comprises: using motion data recorded with a sensor in communication with the heart to identify motion in the heart; and estimating a value associated with heart wall tension based on the identified motion in the heart. The motion in the heart that forms the basis of the estimation may be a vibration in the heart wall. A heat monitoring system for carrying out the method of estimating a value associated with heart wall tension comprises a sensor configured to be placed in communication with the heart in order to identify motion in the heart; and a data processing device arranged to receive motion data from the sensor and to then carry out the steps of the method.

Abstract: Disclosed herein are in vivo non-invasive methods and devices for the measurement of the hemodynamic parameters, such as blood pressure, cardiac output, stroke volume and vascular tone, of a subject, and the mechanical anelastic in vivo properties of the subject's arterial blood vessels. An exemplary method requires obtaining the peripheral pulse volume waveform (PVW), the peripheral pulse pressure waveform (PPW), and the peripheral pulse velocity waveform (PUW) from the same artery; calculating the time phase shift between the PPW and PVW, and the plot of pulse pressure versus pulse volume; and determining the blood pressures and power law components of the anelastic model from the waveforms PPW and PVW, the cardiac output from the waveforms PPW and PUW, and the quality factor of the artery based upon the calculations. The disclosed methods and devices can be used to diagnose and treat cardiovascular disease in a subject in need thereof.

Abstract: A medical capsule with a sensor device comprising a light emitting element and a light detecting element with the sensor device being adapted to detect the presence or non-presence of blood and/or Biliverdin based on the light absorption properties of blood and Biliverdin. The capsule is provided with a casing forming a gap at its outer surface. The light emitting element alternatively emits violet light of a wavelength of about 380-450 nm, green light of a wavelength of about 530-580 nm, and red light of a wavelength of about 620-750 nm, whereas the light detecting element generates a separate sensor signal associated with measured light intensities Iviolet, Igreen, and Ired of at least each of the wavelength ranges of the light from the light emitting element. By evaluating a quotient Ired/Igreen, false-positive detection of blood can be avoided. The present disclosure also relates to a calibration method for said medical capsule.

Abstract: The present invention relates to a device, system and method for determining pulse pressure variation of a subject. To enable more reliably determining pulse pressure variation of a subject the device comprises a signal input (11) configured to obtain an input signal representing a hemodynamic signal of the subject, a processor (12) configured to process the input signal and compute a pulse pressure variation and a signal output (13) configured to output the computed pulse pressure variation. The pulse pressure variation is computed by deriving a pulse height signal from the input signal, deriving a pulse height baseline and a de-trended pulse height signal from the pulse height signal as the ratio between the difference between extrema of the de-trended pulse height signal and the respective value of the pulse height baseline signal, and computing the pulse pressure variation from the de-trended pulse height signal and the pulse height baseline.

Abstract: The blood pressure measuring device (1) is designed as a photoplethysmographic measuring system which functions according to the “vascular unloading technique”. Metrological components and a pressure generating and pressure control system are accommodated in the base part (3). The fitted cuff part (2) has an ergonomic palm support (4), two finger supports (6) divided from one another by a web (5), and also a receiving part (7) which comprises two receiving tubes (9) for fingers. The cuff part (2) projects beyond the base part (3), both towards the front and also towards the rear, and covers the base part (3) almost completely, i.e. by more than 90%. The lateral attachment of the cable (8) facing in the direction of the forearm has the advantage that the cable can be guided along the patient's arm, the wrist does not rub against the cable (8), and in particular the carpal tunnel is also protected.

Abstract: The devices and methods generally relate to vibratable sensors for measuring ambient fluid pressure, in particular implantable sensors. The devices and methods are suited to implantation within the body to monitor physiological conditions, such as portal and/or hepatic venous blood pressure, and allow frequent, remote interrogation of venous pressure. The sensor devices are relatively small compared to conventional devices for measuring fluid pressure and can be implanted in the portohepatic venous system, whereas conventional devices are too large. The small size of the device is accomplished by using a thick sensor membrane, compared to conventional devices, and by limiting the size of additional elements of the device relative to the size of the sensor membrane. The thicker sensor member also obviates the need for multiple sensor arrays and maintains the accuracy and robustness of the sensor device. A data capture, processing, and display system provides a pressure measurement reading.

Abstract: A cuff structure is provided in a curler of a blood pressure measurement device that includes a device body and the curler provided on the device body. The curler curves following along a circumferential direction of a wrist. The cuff structure includes a sensing cuff provided on a side of an inner circumferential surface of the curler and contacting a region where an artery is present in the wrist and a pressing cuff having a portion provided between the curler and the sensing cuff, having a portion of another portion of the cuff disposed in a region where the sensing cuff is present in an outer circumferential surface of the curler with the blood pressure measurement device attached to the wrist, and inflating to press the sensing cuff to the wrist.

Abstract: To provide a cuff structure capable of improving measurement accuracy of blood pressure, and a blood pressure measurement device. A cuff structure includes a sensing cuff configured in shape that is long in one direction and coming into contact with a region of a wrist where an artery is present, a pressing cuff configured in a shape that is long in one direction, provided on a side of the sensing cuff opposite from the wrist side surface, and pressing the sensing cuff against the wrist by being inflated, and a wall portion provided along at least one edge portion along a longitudinal direction of the sensing cuff and having a leading end surface on the wrist side coming into contact with the wrist.

Abstract: The two inflatable sleeve cushions (10) which can be arranged in the receiving tubes (9) are each connected by means of a connection (11) at the interface between sleeve part (2) and base part (3) to the pressure generation and pressure control system in the base part (3). A valve device is preferably provided on the connection (11). The channels (19) that connect the respective connection (11) to the respective sleeve cushion (20) are formed in the main body (21) of the receiving body, said main body being produced from plastic by means of injection moulding, and are covered towards the outside by means of a cover (20). The connections (11) are disposed one behind the other in the direction parallel to the axial direction of the receiving tubes (9). From there, each channel (19) is first guided upwards, then diagonally to the side, and finally downwards to the fluid access opening (22) of the respective sleeve cushion (10).

Abstract: The present technology provides a living body information measurement apparatus and a living body information measuring method that make it possible to discriminate a state of a living body with high accuracy. The present technology provides a living body information measurement apparatus including: a sensor device that applies light to a living body and individually detects light scattered by a plurality of parts in the living body; and a processor that discriminates a state of the living body on the basis of outputs of the sensor device for the respective parts. According to the present technology, it is possible to provide a living body information measurement apparatus and a living body information measuring method that make it possible to discriminate the state of the living body with high accuracy.

Abstract: A new system and method is provided for improving the accuracy of pulse rate detection. Various aspects contribute to the greater accuracy, including but not limited to pre-processing of the camera output/input, extracting the pulsatile signal from the preprocessed camera signals, followed by post-filtering of the pulsatile signal. This improved information may then be used for such analysis as HRV determination, which is not possible with inaccurate methods for optical pulse rate detection.

Abstract: Systems, methods, apparatuses, and computer program products for contactless image-based blood oxygen estimation. A method may include receiving an image or video of a part of a subject captured by a camera of a computing device. The method may also include extracting a region of interest of the part of the subject from the image or video. The method may further include performing feature extraction of the region of interest. In addition, the method may include estimating a blood oxygen saturation level of the subject based on a spatial and temporal data analysis of more than two color channels. Feature extraction and estimation of the blood oxygen saturation level may include implementing a combination of spatial averaging, color channel mixing, and temporal trend analysis.

Abstract: We disclose an improvement for oximeters, which makes oximeters more reliable when making measurements on patients of darker skin complexion. The device of our invention discloses a re-entrant cavity, inside which some of the tissues of the patient are forced into, by pressing the device of our invention against the skin of the patient. The probing electromagnetic radiation beams (typically deep red and infra-red radiation) are directed to propagate through said re-entrant cavity, inside which some of the outer tissues of the patient are forced, along a path that is approximately parallel to, and just under, the skin of the patient. This probed volume inside said re-entrant cavity contains more arterial and less venous blood, when compared with measurements made by perpendicular beams, that penetrate deep under the skin, which causes that the measurements made by our device are more accurate than many existing oximeters.

Abstract: A garment cuff for detecting physiological data. The garment cuff includes: an elongate band having a first region and a second region and defining an adjustable loop for receiving a user limb based on the first region being positioned proximal the second region. The garment cuff includes a stiffener member coupled to the first region to define a substantially rigid base and a sensor panel affixed to the substantially rigid base on a user limb facing side of the first region. The garment cuff includes a fastener coupled to the elongate band and configured to position the sensor panel against the user limb with substantially consistent pressure.

Abstract: In some embodiments, an electric field generator includes a differential oscillator that oscillates at a nominal frequency. The electric field generator is connected to a differential antenna that radiates an electric field. A differential detector measures a frequency of the generated electric field as the electric field interacts with a body (such as a human body) in a reactive near-field region of the electric field. For each of one or more internal components of the body, a computation unit determines a respective periodic behavior in the measured frequency indicative of movement of the internal component. The computation unit also computes, for each of the one or more internal components of the body, a respective rate of movement (such as a heart rate or a respiration rate) of the internal component according to the respective periodic behavior in the measured frequency.

Abstract: In some embodiments, an electric field generator generates an electric field at a nominal frequency and a nominal amplitude. The electric field generator is connected to an antenna that radiates the electric field. A detector measures a frequency and an amplitude of the generated electric field as the electric field interacts with a body (such as a human body) in a reactive near-field region of the electric field. For each of one or more internal components of the body, a computation unit determines a respective periodic behavior in the measured frequency corresponding to movement of the internal component. The computation unit also computes, for each of the one or more internal components, a respective rate of the movement of the internal component based on the determined respective periodic behavior in the measured frequency. A gain control circuit adjusts the nominal amplitude according to the measured amplitude.

Abstract: An accessory kit is provided for interventional procedures using a magnetic resonance imaging scanner. The accessory kit includes a patient support and an electrical connection adapter. The patient support has a first end proximal and a second end distal to the scanner. The distal end is configured to create a space to accommodate a clinician, such as narrowing of the distal end or at least one cutout on a side of the distal end. The electrical connection adapter interfaces with the scanner and a scanner table. The accessory kit is configured so that when the proximal end is extended into the scanner bore, the distal end extends outside the bore. The narrowed width and/or cutout(s) of the exposed distal end and the extended gap between the scanner and scanner table create space on at least one side of the patient support that a clinician may use to access a patient.

Abstract: A detection device for detecting and characterizing biological energy fields emitted by biological specimens is configured to collect and analyze an electromagnetic signal that includes millimeter-length waves generated by the interaction of atmospheric plasma with torsion waves of the biological energy field. The device performs spectral analysis on the millimeter waves to determine characteristics of the corresponding torsion waves that generated them. An array of several hundred non-thermal plasma plumes are placed directly in front of a circular horn. A switchable circular polarizer is used to select left hand circular, linear or right hand circular polarization. A low noise frequency converter allows a noise temperature of less than 1150 K. A frequency scan and averaging algorithm is developed to characterize noise temperature versus frequency, comparing signal and noise levels between plasma on and plasma off, and switching polarization sense.

Abstract: Tumor treating fields (TTFields) can be delivered to a subject's body with improved safety and efficacy by determining the condition of participating electrode elements and/or the subject's skin condition under positioned electrode elements. This may be accomplished by applying an AC signal to pairs or groups of electrode elements and taking corresponding impedance measurements. In some embodiments, the impedance measurements are indicative of electrode element condition and/or skin condition. These determined conditions can be used to adjust or pause TTFields treatment, for example to permit skin recovery or to ensure that participating electrode elements will properly function.

Abstract: Impedance devices with integrated circuit modules and method of using the same to obtain luminal organ information. In one embodiment, a device comprises an elongated body for at least partial insertion into a mammalian luminal organ and having a first conductor extending therethrough, a proximal electrical unit connected to the elongated body to deliver power along the first conductor, and a sensor substrate located at or near a distal end of the elongated body and comprising a circuit module operable and/or configured to direct the sizing portion to obtain sizing data and the pressure sensor to obtain pressure data, and facilitate transmission of the sizing data and/or the pressure data to the proximal electrical unit.

Abstract: Disclosed is a method to remove distortion from a navigation system. The navigation system may be used to perform a procedure on a subject. The procedure may be any appropriate procedure. The navigation system may be used to account for the distortive effects of various conductive objects positioned near the subject on which the procedure is performed.

Abstract: A method of diagnosing an air leak in a lung compartment of a patient may include: advancing a diagnostic catheter into an airway leading to the lung compartment; inflating an occluding member on the catheter to form a seal with a wall of the airway and thus isolate the lung compartment; measuring air pressure within the lung compartment during multiple breaths, using the diagnostic catheter; displaying the measured air pressure as an air pressure value on a console coupled with the diagnostic catheter; and determining whether an air leak is present in the lung compartment based on the displayed air pressure value during the multiple breaths.

Abstract: Devices, systems, and methods for monitoring respiration using surface temperature, humidity, air pressure, carbon dioxide gas sensors, pulse oximetry sensors and electromyography sensors, and/or acceleration sensors to obtain information related to respiration rate (RR), exhalation/inhalation strength, exhalation/inhalation volume, exhalation/inhalation acceleration, and/or exhalation/inhalation regularity.

Abstract: Alveolar dead space of a subject is determined by measuring an end tidal partial pressure of carbon dioxide during a sequence of normal breaths of the subject and, during a sequence of deep breaths by the subject, delivering a first volume of a first gas to the subject over a first portion of each inspiration by the subject. The first volume is less than or equal to an expected alveolar volume of the subject when the subject is breathing normally. A second volume of a second gas is delivered to the subject over a second portion of each inspiration. The second gas includes a neutral gas. An end tidal partial pressure of carbon dioxide is measured during the sequence of deep breaths. The alveolar dead space is computed using the end tidal partial pressures of carbon dioxide measured during the sequence of normal breaths and the sequence of deep breaths.

Abstract: A load measurement device includes an acquisition unit, a load calculation unit, and an output unit. The acquisition unit acquires sensor output information of a load distribution sensor that detects a load distribution received from a sole of a subject. The load calculation unit calculates a total load value, based on the sensor output information and geometric information of a load region specified based on the sensor output information, the geometric information including at least a perimeter of the load region in a horizontal direction. The output unit outputs the total load value.

Abstract: Methods and systems for assessing a biological movement are described. The method comprises obtaining a sequence of samples of a signal from a sensor; determining a set of initial parameters from the signal, the initial parameters comprising trajectory, speed, acceleration and direction data for the sequence of samples; segmenting the signal into first layer segments based on changes in the direction of the trajectory of the sequence of samples; segmenting the first layer segments into second layer segments based on the acceleration data; determining target points of the second layer segments using parameters from the first layer segments and the second layer segments; segmenting the first layer segments into third layer segments based on changes in the trajectory or the acceleration of the sequence of samples; and determining a set of output parameters based on the segmenting and the target points, the output parameters comprising timing information and command information for the biological movement.

Abstract: A quantitative gait training and/or analysis system includes one or more footwear modules that may include a piezoresistive sensor, an inertial sensor and an independent logic unit. The footwear module functions to permit the extraction of gait kinematics and evaluation thereof in real time, or data may be stored for later reduction and analysis. Embodiments relating to calibration-based estimation of kinematic gait parameters are described.

Abstract: Calibration of a sensing device is provided. The sensing device includes a sensor configured to sense a condition. In the sensing device, a voltage-dividing resistance and a reference voltage of an analog-to-digital converter are set to configure a quantization range of the analog-to-digital converter given characteristics of the sensor. During calibration, a binary search is performed between lower and upper limits of the voltage-dividing resistance, which is a variable resistance, to find the resistance of the voltage-dividing resistance at which the sensing device is operated.

Abstract: A state determination method, a state determination device, a state determination system, and a recording medium are provided for determining a state of a living body based on electrical signal according to a detected vibration. A state determination device 2 acquires electrical signal according to a detected vibration, and operates: a rectification unit (step S2); an envelope detection unit to derive an envelope from the rectified electrical signal (step S3); and a state determination unit to determine the state of the living body based on the derived envelope (step S4). The state determination device 2 that has determined the state of the living body outputs a determination result (step S5).

Abstract: A processing system obtain signals that are generated by or generated based on sensors that are included in one or more hearing instruments. Additionally, the processing system determine, based on the signals, whether a posture of a user of the hearing instruments is a target posture. The processing system generate information based on the posture of the user.

Abstract: A system includes a sensor configured to generate data associated with movements of a resident for a period of time, a memory storing machine-readable instructions, and a control system arranged to provide control signals to one or more electronic devices. The control system also includes one or more processors configured to execute the machine-readable instructions to analyze the generated data associated with the movement of the resident, determine, based at least in part on the analysis, a likelihood for a fall event to occur for the resident within a predetermined amount of time, and responsive to the determination of the likelihood for the fall event satisfying a threshold, cause an operation of the one or more electronic devices to be modified.

Abstract: Disclosure is a hearing threshold and/or hearing state detection system and method. The system comprises: an acquisition and transmission system configured to transmit stimulation signals and acquire an ear canal signal; and a hearing threshold analysis and prediction system including a hearing threshold detection module, a routine testing module and/or a hearing state screening module, wherein the hearing threshold detection module determines hearing thresholds at different stimulation frequencies through a pre-trained network model; the routine testing module adaptively selects a range of test intensities through the acquisition and transmission system, and predicts hearing thresholds related to different stimulation frequencies through a pre-trained network model; and the screening module is configured to perform hearing state screening through the acquisition and transmission system and a pre-trained network model.

Abstract: A method of preparing a working electrode on a sensor substrate is disclosed. A sensor substrate is provided and has a first side with at least one conductive trace. A layer of sensing material is applied onto the first side and covers at least a portion of the at least one conductive trace. The sensing material is irradiated with a laser beam to partially remove the layer of the sensing material while preserving a portion of the sensing material covering the at least one conductive trace, resulting in a working electrode on the sensor substrate. A membrane layer is applied that at least partially covers the working electrode. The membrane layer includes a cross-linker that cross-links at least a part of the sensing material. A diffusion step is performed during which the cross-linker in the membrane layer at least partially diffuses into the sensing material.

Abstract: A laparoscopic medical device includes an oximeter sensor at its tip, which allows the making of oxygen saturation measurements laparoscopically. The device can be a unitary design, wherein a laparoscopic element includes electronics for the oximeter sensor at a distal end (e.g., opposite the tip). The device can be a multiple piece design (e.g., two-piece design), where some electronics is in a separate housing from the laparoscopic element, and the pieces (or portions) are removably connected together. The laparoscopic element can be removed and disposed of; so, the electronics can be reused multiple times with replacement laparoscopic elements. The electronics can include a processing unit for control, computation, or display, or any combination of these. However, in an implementation, the electronics can connect wirelessly to other electronics (e.g., another processing unit) for further control, computation, or display, or any combination of these.

Abstract: Glucose monitoring devices and related systems and methods, the glucose monitoring devices including a sensor electronics unit having a housing and a printed circuit board disposed within the housing, a transcutaneous glucose sensor assembly, and a conductive sensor connector. The printed circuit board includes a first electrical contact, the transcutaneous glucose sensor assembly includes a distal portion having a working electrode and proximal portion having a working-electrode contact in electrical communication with the working electrode, and the conductive sensor connector electrically connects the working-electrode contact with the first electrical contact. Further, the conductive sensor connector extends through a hole in the proximal portion of the transcutaneous glucose sensor assembly and through a hole in the printed circuit board.