Abstract: Disclosed herein are polypeptides for use in treating diseases. Therapeutic uses and methods for treating diseases are also disclosed. Also disclosed is a method and associated peptides and nucleic acids for active, long-term delivery of therapeutic molecules to target cells in vivo or in vitro.

Abstract: Provided herein are isolated DNA vectors comprising a heterologous gene, wherein the DNA vector is devoid of bacterial plasmid DNA and/or bacterial signatures, which can abrogate persistence in vivo. The invention also features pharmaceutical compositions (non-immunogenic pharmaceutical compositions) including the DNA vectors of the invention, which can be used for induction of long-term, episomal expression of a heterologous gene in a subject. The invention involves methods of treating a subject by administering the DNA vectors of the invention, including methods of treating disorders associated with a defect in a target gene.

Abstract: The present disclosure provides a fluorescently-traceable amino acid derivative and a preparation method and use thereof, and belongs to the technical field of biomedicine. In the present disclosure, an amino acid skeleton of the amino acid derivative is modified mainly by a fluorescently-traceable functional group. 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) has low polarity and strong fluorescence, and can be used to modify an N-terminal of the amino acid skeleton to conduct subcellular imaging. Moreover, the NBD-Cl has a relatively small volume, lacks reaction orthogonality, and causes little interference with biochemical reactions of the organism itself. The results of examples show that the fluorescently-traceable amino acid derivative has a desirable biological activity and can be fluorescently traced in vivo and in vitro.

Abstract: Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1: In Chemical Formula 1 above, X1 and X2 are the same as or different from each other, and each independently selected from H, —SO3? and SO3H, R1 and R2 are the same as each other or each independently selected from C1-7 alkyl, C8-18 alkyl, —(CH2)mSO3?, —(CH2)mSO3H, and R3 and R4 are the same as or different from each other and each independently selected from C1-7 alkyl, —(CH2)mCOOZ and R3 and R4 are simultaneously not any one selected from —(CH2)mCOOZ and

Abstract: Liposomes have been used in technologies in biological, pharmaceutical, medical and nutritional applications because they can offer biocompatibility, biodegradability, reduced toxicity, and capacity for size and surface modifications. Traditionally, liposomes are prepared by multiple steps. However, multiple steps of preparation may cause a number of problems including low yield, high polydispersity, and poor morphology. Here, we synthesized liposomes containing magnetic iron oxide nanoparticle using one-pot, single step synthesis under ultra-sonication. We optimized the lipid compositions, sonication power, concentration of iron oxide nanoparticles, and antibody conjugation using Cu-free click chemistry. Furthermore, we incorporated doxorubicin inside magnetic liposomes for combined antibody targeting and magnetic guidance. Fluorescence imaging and quantification confirmed that antibody conjugated magnetic liposome showed high cell specific targeting that was enhanced by magnetic delivery.

Abstract: A chelator having the general structure (I) for chelating ra-diometals such as 225Ac under mild conditions is provided. (I) The chelator can be coupled to a biological targeting moiety to facilitate targeted delivery of the chelated radiometal in a mammalian subject.

Abstract: A 68Ga-labeled gastrin analogue and its use in peptide receptor radionuclide diagnostic applications is provided. In particular, a 68Ga-labeled minigastrin analogue for use in a method of imaging one or more cholecystokinin B receptor positive diseases selected from small-cell lung cancer, extrapulmonary small-cell carcinoma and medullary thyroid cancer is provided. A kit including the gastrin analogue is also provided.

Abstract: Radiolabeled anti-LAG3 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of LAG3 proteins in a patient or sample.

Abstract: Combination therapies comprising administering radioimmunoconjugates and one or more checkpoint inhibitors.

Abstract: The present invention provides a system for eliminating microorganisms comprising a plurality of light emitters, wherein each of the plurality of light emitters is configured to emit light comprising a wavelength of 380-500 nm, and wherein at least two or more of the plurality of light emitters emit light of a different wavelength. There is also provided a method of eliminating microorganisms comprising emitting a light of a wavelength of 380-500 nm by each of a plurality of light emitters.

Abstract: A flow path is disclosed that comprises a suction part that suctions a fluid and a discharge part that discharges the fluid, the flow path being configured so that the path thereof is defined as non-linear and is set so as to be longer than the linear distance of the flow path; and a decreasing/eliminating means in which a subject contained in the fluid and flowing downstream in the flow path is subjected to decomposition and/or deactivation and/or sterilization.

Abstract: An object of the present invention is to provide an ultraviolet light irradiation system and a decontamination method that can perform decontamination economically without any input from a user. The ultraviolet light irradiation system forms a linear or planar ultraviolet light irradiation space by spatially bundling a plurality of ultraviolet light beams with high energy density or moving the ultraviolet light with high energy density at high speed. The ultraviolet light irradiation system can decontaminate a human body and clothing simply by passing through the space. Further, since the ultraviolet light irradiation system performs decontamination in the space, bacteria and viruses emitted from a carrier are not passed through the space.

Abstract: An apparatus for sanitising a target comprises a supply of a sanitising substance comprising a gas and/or plasma of nitric oxide and/or ozone, and a conduit arranged to direct the sanitising substance onto a target to sanitise the target. FIG. 13(a) shows a sanitiser product generator device 1200 which is arranged to release a sanitising product into an elevator 1220 via channel 1240. The sanitising product will destroy bacteria and virus within a mixing chamber before being released back into the lift shaft and lift cabin free from contaminants and may permeate the entire enclosed volume of the elevator, thereby destroying bacteria and virus in the air and on the surfaces of the elevator, circulating clean air and cleaning any contaminated air incoming via opening of the elevator doors or from passengers coughing and sneezing, for example.

Abstract: A cleaning kit. The cleaning kit including a first liquid-tight container including a solute and a second liquid-tight container including a solvent adapted to be received within the first container to be ruptured by the application of pressure to the container by a user. The second container includes a sealable liquid-tight pouch; and a frangible seal along at least a portion of an outer edge of the pouch, wherein the frangible seal is broken by the application of pressure to the second container by a user greater than about 30 inches of water when tested according to ASTM Test F1140-07 (2007), wherein the second container is adapted to be openable while it is located in the first container to release the solvent from the second container into the first container, whereby the solute and the solvent are combined to form a cleaning liquid.

Abstract: In one aspect, a system for generating and monitoring an antimicrobial is provided, the system including: a microprocessor and/or a microcontroller; an external communications device; a computational system; an antimicrobial sensor and/or an environmental sensor; and an antimicrobial generator, wherein the external communications device, the computational system, the antimicrobial generator, and the antimicrobial sensor and/or the environmental sensor are operatively connected to the microprocessor and/or the microcontroller. The system may further include a separate sensor sub-system comprising: a sensor sub-system microprocessor and/or a sensor sub-system microcontroller; a sensor sub-system external communications device; a sensor sub-system antimicrobial sensor and/or a sensor sub-system environmental sensor; and a sensor sub-system computational system.

Abstract: A process for disinfecting a vehicle includes identifying an end of operations of the vehicle, dispersing a nebulized disinfectant into the internal compartment, displaying a progress bar such that the progress bar is visible external to the compartment, wherein the progress bar is indicative of a time remaining in the duration of a disinfectant process, and allowing access to the internal compartment at an expiration of the time remaining in the disinfectant process.

Abstract: A hydrogen peroxide sterilization device for sterilizing a medical device, the hydrogen peroxide sterilization device including a hermetic outer container, a hydrogen peroxide pouch, and a hydrogen peroxide solution in the solution chamber. The hermetic outer container includes a sterilization enclosure configured to receive the medical device. The hydrogen peroxide pouch includes a permeable membrane enclosing a solution chamber and is configured to be positioned in the sterilization enclosure of the outer container. The permeable membrane is configured to allow hydrogen peroxide vapor to diffuse from the solution chamber through the permeable membrane into the sterilization enclosure.

Abstract: Methods and systems are provided for verifying hygienic hand cleaning including a wash basin, having a contaminant sensor positioned in proximity to a drain of the wash basin, to measure a level of contamination of rinse fluid leaving the wash basin; and a processor and associated memory having instructions that when executed by the processor implement: receiving a signal from the contaminant sensor indicative of the level of contamination; and responsively, determining the level of contamination and comparing the level of contamination with a contamination threshold to determine a hand washing status.

Abstract: The disclosed robot enables the efficient transportation of objects scattered over a wide area.

Abstract: A counting unit is provided for use in an electrical device. The counting unit is configured to count a thermal event such as an autoclave cleaning operation when the electrical device is not electrically powered. In one aspect, the counting unit includes a rotary member and an actuator, the actuator is configured to change shape from a first configuration to a second configuration when subjected to a predetermined temperature, wherein in the second configuration, the actuator engages the rotary member so as to rotate the rotary member. In another aspect, the counting unit includes a plunger, a drive and a heat resistant arm configured to release the plunger during a thermal event and retain the plunger when the electrical device is cooled down.

Abstract: A room region (1) for an aircraft is provided, which room region comprises a disinfecting device (3) for disinfecting at least one surface (4) of the room region (1), wherein the disinfecting device (3) is designed to disinfect the surface (4) of the room region (1) by means of UVC radiation (5). The disinfecting device (3) comprises a lighting apparatus (6) for generating and emitting the UVC radiation (5). The lighting apparatus (6) is portable, and, in an active state, the lighting apparatus (6) is stationary and arranged.

Abstract: The present invention relates to a device for keeping room air clean and a corresponding method.

Abstract: An embodiment of the present disclosure may include a base for a scent warmer. The base may include a base member and a stem extending upwardly from the base member. The stem may be configured to carry a heating element thereon. The base may also include an elastomeric sleeve surrounding at least a portion of the stem. The elastomeric sleeve may be configured to apply a retention force between a removable decorative body and the stem. The elastomeric sleeve may include a wall member sized and configured to abut against the stem and a plurality of ribs extending radially outward from the wall member.

Abstract: Apparatus for releasing a volatile substance, in particular a fragrance or an insecticide, into ambient air, the apparatus includes a housing made of a first material which has a plant-based fiber material, and a barrier layer having a barrier function against permeation of the volatile substance, and arranged inside the housing, the apparatus includes an insert made of a second material, the second material is provided or impregnated with the volatile substance, wherein the second material has one or more of: i) a plant-based fiber material or ii) sucrose or starch or iii) a mineral material.

Abstract: The mitigation of indoor pathogens comprises quantifying, using a bio-aerosol monitoring system, the amount of total pathogens in the air and on surfaces within an indoor environment. Moreover, the process comprises sanitizing the indoor environment with portable equipment to stabilize the indoor environment when it is determined that the indoor environment is contaminated. Also, the process comprises installing a purification device within a contaminated area of the indoor environment, and monitoring continuously, the indoor environment after sanitizing, for pathogens. Still further, the process comprises releasing a purifying agent upon detecting pathogens in the indoor environment, and providing periodic maintenance to the purification device.

Abstract: Disclosed is a formulation which, in association with a grinding system, transforms biohazardous wastes unto raw material for the preparation of composts, enabling biohazardous infectious waste to be inactivated for use and industrial biohazardous infectious waste to be inactivated for reuse as a protein source for producing protein products. The formulation can be used to eliminate microorganisms in waste resulting from the production of drugs and vaccines in ovo, with applications in biohazardous infectious waste and animal waste with a high protein content and decomposition potential for the preparation of composts.

Abstract: A medical polyurethane foam dressing and a preparation method thereof are provided in this disclosure. The medical polyurethane foam dressing includes a polyurethane film, a hydrophilic polyurethane foam layer compounded on the polyurethane film, a release paper provided on the hydrophilic polyurethane foam layer, and a soft silicone composite layer located below the release paper. The polyurethane film consists of a release film and a PU resin layer or TPU resin layer coated on the release film. Products prepared according to the disclosure not only can serve to absorb wound exudate of pressure sore, but also provides single-side water proofing; and it is sticky and can be stably fixed on the wound without easy displacement, thus ensuring continuous and stable liquid absorption.

Abstract: The present invention relates to a haemostatic material comprising a haemostat agent and a bioadhesive agent. Such a haemostatic material is useful, for example, in effectively controlling bleeding with a reduced compression period compared to the TCCC guidance of a minimum of three minutes compression using a haemostatic bandage.

Abstract: A calcium-deficient silicate-substituted calcium phosphate apatite composition comprises an apatite phase having a Ca/P molar ratio of from greater than 2.15 to 2.30, and a Ca/(P+Si) molar ratio of from 1.45 to 1.55. A method of producing a calcium-deficient silicate-substituted calcium phosphate apatite composition comprises contacting a silicate-substituted calcium phosphate apatite starting material with an acidic solution to produce the calcium-deficient silicate-substituted calcium phosphate apatite composition. The starting material comprises an apatite phase and up to 15 wt % total of a phase or phases other than the apatite phase, and has a Ca/P molar ratio of from 2.3 to 2.6, and a Ca/(P+Si) molar ratio of from 1.56 to 1.66, and the calcium-deficient silicate-substituted calcium phosphate apatite composition comprises an apatite phase having a Ca/P molar ratio lower than the Ca/P ratio of the starting material apatite phase.

Abstract: Compositions containing purified collagen biomaterial derived from tissues, for example, insoluble amnion, soluble amnion, soluble chorion of the human placenta, are provided. The collagen compositions can be used to promote wound healing, promote tissue regeneration, prevent or reduce scarring, reduce local inflammation, minimize tissue rejection, promote graft integration. Methods for using the collagen composition as a biomaterial implant for dermal filling, skin grafting, and hair transplantation are also provided.

Abstract: A heart valve replacement device and methods of manufacturing same are provided. The heart valve replacement device includes a substrate and a low-profile composite covering in conformal contact with the substrate and suturelessly attached to the substrate. The low-profile composite covering includes a textile base layer and a thermoplastic polymer coating integrated with the textile base layer. The thermoplastic polymer coating or select portions thereof are substantially fluid impermeable.

Abstract: An implantable and biodegradable polymeric matrix with reduced foreign body response for the regeneration and/or reconstruction and/or creation of soft and connective tissue and/or organs is provided. The matrix has a density equal to or lower than 40 kg/m3, a plurality of local thicknesses of a solid component with an arithmetic mean equal to or lower than 95 ?m, an average size of pores/void spaces equal to or lower than 15,000 ?m, a surface roughness Ra of the solid component with an arithmetic mean equal to or lower than 3 ?m; and a contact angle ? of the solid component lower than 110°, preferably in the range 10° to 90°, and more preferably in the range 30° to 60°.

Abstract: Described are methods of making vascular grafts from man-made tubular scaffolds, tubular scaffolds, and methods implanting vascular grafts comprising tubular scaffolds into subjects. The tubular scaffolds of the present invention are made of hydrogel nanofibers that have internally aligned polymer chains and may be cellularized.

Abstract: The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 ?m in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.

Abstract: Provided are an implantable medical device (100) and a method for manufacturing the same, and a method for manufacturing a stent. The implantable medical device (100) comprises a metal base (110) and a cladding layer (120). The cladding layer (120) is a nickel-free and cobalt-free metal layer which is deposited on the metal base (110) by means of a metal bond. The arrangement of the cladding layer (120) of the implantable medical device (100) on the metal substrate (110) can prevent carcinogenic elements in the metal base (110) such as nickel and cobalt from dissolution. Moreover, the cladding layer (120) is a nickel-free and cobalt-free metal layer, such that the implantable medical device (100) is free from problems of nickel or cobalt dissolution, thereby improving the biological safety of the implantable medical device (100).

Abstract: A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line made of a distensible material that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. When an incremental volume of additional solution is provided to the patient line while the occlusion is present, a change in pressure results. The change in pressure depends on the dimensions and the distensibility of the non-occluded portion of the patient line. If the change in pressure, the incremental volume, the properties related to the distensibility of the patient line, and some of the dimensions of the patient line are known, the location of the occlusion can be inferred. The occlusion type can be inferred based on the determined location.

Abstract: A blood circuit and a dialysate circuit bidirectionally circulate a fluid through a blood purification membrane of a blood purifier, and include a first flow route that causes a dialysate to flow from the dialysate circuit into the blood circuit through a connection flow route connecting the dialysate circuit to the blood circuit while bypassing the blood purifier, and a second flow route that causes the dialysate to flow from the dialysate circuit into the blood circuit through the blood purification membrane. The controller performs control such that blood in the blood circuit is returned to the body by feeding the dialysate to one of these flow routes, determine if a flow amount of the dialysate reaches a predetermined flow amount, and control such that the blood in the blood circuit is returned to the body by feeding the dialysate to the other one of these flow routes.

Abstract: The present invention is directed to wall box for hemodialysis interface having two isolated zones. The first zone is a clean interface zone having sources of purified water and dialysis fluids. The second zone is a waste interface zone comprising waste connectors and a waste drain.

Abstract: Provided is a blood dialyzing apparatus having multiple fluid chambers each having an internal space, a chamber pressurizing member compressing or expanding the internal spaces of the chambers, a chamber pressurizing member driver driving the chamber pressurizing member, and a flow control unit. The chambers are each connected with a first flow tube through which a fluid is provided to the chamber and a second flow tube through which a fluid of the chamber is discharged therefrom. The flow control unit controls a flow through the flow tubes connected to the multiple fluid chambers.

Abstract: A processing system includes a processor including a separator, a set configured to cooperate with the separator to separate whole blood into plasma and other components, the set including an inlet line attachable to a patient to receive whole blood and an return line attachable to a patient to return processed fluid, and a source of replacement fluid connected to the disposable set, the processor configured to combine the other components with replacement fluid to define the processed fluid. The processor includes a controller and an input device coupled to the controller, the controller configured to receive an input via the input device, the input representing a volume of replacement fluid, and to control the processor to separate whole blood passing through the set and to combine the other components with the replacement fluid according to the input until the source of replacement fluid is empty.

Abstract: The present invention provides biological molecules for use in detecting, identifying and/or removing microbes and microbial components; diagnostic, therapeutic and filtration devices comprising the biological molecules; and systems and methods for treating fluids using the biological molecules and devices of the invention.

Abstract: A continuous flow centrifuge bowl includes a rotatable outer body, and a top and bottom core that are rotatable with the outer body. The bottom core has a wall extending proximally from a bottom wall. The proximally extending wall is radially outward from at least a portion of the top core and, together with the top core, defines a primary separation region in which initial separation of the whole blood occurs. The bowl may also have a secondary separation region located between the top core and the outer body, and a rotary seal that couples an inlet port and two outlet ports to the outer body. The inlet port may be connected to an inlet tube that extends distally into a whole blood introduction region. Additionally, one of the outlet ports may be connected to an extraction tube that extends into a region below the bottom core.

Abstract: A fluid separation system and method includes a durable hardware component including a pump station with plurality of pumps, a centrifuge mounting station and drive unit, a plurality of valves and clamps, and a controller. The system includes a single use fluid flow circuit having a separation chamber configured to be received by the centrifuge and the fluid flow circuit is engageable with the durable hardware component to control fluid flow within the fluid flow circuit. The fluid flow circuit having an air access component configured to selectively receive air and to provide the air into a conduit to induce plug flow between the separated fluid component and another separated fluid component, wherein the controller is configured to operate the system to perform one or more blood processing procedures to convey a fluid into the separation chamber and to remove a separated fluid component from the separation chamber.

Abstract: A method for operating an elastically mounted forming machine which is path-bound or force-dependent, in which method a working stroke of a ram device operatively connected to the drive is initiated by means of a drive, and a predefined forming process is carried out on a workpiece by moving the ram device during said working stroke, in particular due to the interaction of an upper tool located on the ram device with a lower tool located on a tool table, wherein the inertial forces and/or moments of inertia occurring during operation owing to the initiation of the working stroke and/or owing to an imbalance in the drive are at least partially compensated.

Abstract: Embodiments of a fluid warming container and a fluid warming device are described. The fluid warming container defines an interior volume arranged to receive a liquid. The fluid warming container also includes a heating element, a power source, and a switch configured to selectively control a flow of electrical current from the power source to the heating element to warm the liquid. The fluid warming device includes an elongate housing, a heating element, a power source, and a switch configured to selectively control a flow of electrical current from the power source to the heating element to warm a liquid in contact with the fluid warming device.

Abstract: The present invention relates to a self-retaining enema nozzle (1,1?,1?,1??) and an enema system (34) comprising said enema nozzle. The enema nozzle (1,1?,1?,1??) comprises a catheter (2) provided with a retention member (3) arranged for being placed in a compact form during insertion in a body cavity and for being placed in an expanded form for retaining the enema nozzle in said body cavity, and wherein the enema nozzle (1,1?,1?,1??) further comprises a restriction unit (4) arranged for placing the retention member (3) in its compact form. Since the restriction unit (4) holds, e.g. keeps, places and/or maintains the retention member (3) in the compact form both before and during insertion, any discomfort and/or harm that may be experienced using the conventional enema nozzles/devices is effectively prevented.

Abstract: A medication fluid delivery device and methods are provided with the delivery device having a dispensing unit and a drive unit that are attachable together. The dispensing unit includes a dispenser for delivering medication fluid to a user and a reservoir configured to be filled with a variable amount of medication fluid received from a medication fluid injector. The drive unit includes a control unit that controls the drive unit and causes medication fluid in the reservoir to be pumped through the dispenser and includes a registration mechanism configured to act with the dispensing unit to determine a state the reservoir including an initial level of the filled reservoir.

Abstract: An insertion mechanism for a drug pump includes an insertion mechanism housing; a sleeve; a rotational biasing member initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the sleeve. The needle is inserted into a target tissue by the rotational biasing member and interaction between the hub and housing. Retraction of the needle is caused by decompressing or de-energizing of the retraction biasing member. A drug delivery pump includes an activation mechanism, a drive mechanism, a sterile access connection, and the insertion mechanism. Assembly and operation methods are provided.

Abstract: A container assembly for containing and delivering a medicament is described. The container assembly includes a container having a first end and a second end. The first end includes an opening, and a plunger assembly at least partially disposed in the container. The plunger assembly includes a main body and at least one resilient portion at least partially retained by a groove in the main body. The resilient portion forms a seal with the container. The plunger assembly forms a temperature resilient seal with the container such that the container assembly is operable to contain a medicament between the seal and the opening at: (a) room temperature, and (b) during freeze storage of the medicament. The plunger assembly is moveable relative to the container at room temperature.

Abstract: Ambulatory infusion pumps, medicament reservoirs, and medicament sealing assemblies, including a variety of trocar seal assemblies and fill plug seal assemblies, plus related components, as well as component combinations and related methods.