Abstract: An instrument configured to be inserted through a vascular access device includes a helical coil formed by a wire, with the helical coil defining a central passage, and a core wire extending along a longitudinal axis of the helical coil through at least a portion of the central passage of the helical coil. At least a portion of the core wire includes a planar surface extending in a direction along the longitudinal axis and a semi-cylindrical surface extending in a direction along the longitudinal axis.

Abstract: A hemostasis valve hub for a sheath, such as an introducer sheath, includes a hub base including a first arm defining a first lumen and having a distal end and a proximal end and a second arm extending from the first arm and defining a second lumen and having a distal end and a proximal end, a seal positioned within the first lumen and adjacent a lock nut, the lock nut engaged with the proximal end of the first arm and positioned at least partially within the first lumen, a primary seal positioned adjacent the proximal end of the first arm, and a secondary seal positioned adjacent the proximal end of the second arm.

Abstract: A hemostasis valve hub for use with an introducer sheath includes a base having a securing mechanism for securing the hemostasis valve hub to the introducer sheath, an outer shell securable to the base and defining an interior volume, a shutter helix section disposed within the interior volume and including a plurality of fins arranged in a helical fashion, a brush section disposed within the interior volume adjacent the disk shutter section, the brush section including a plurality of brushes arranged in a helical fashion, and a seal positioned within the base and adjacent the brush section, the seal having a partial cross slit arrangement.

Abstract: This patent document discloses devices and associated methods for catheter and guidewire management in a surgical setting. Implementations can include a hemostasis valve configured to prevent the backflow of blood during a medical procedure. The hemostasis valve can have a valve body defining an inner lumen extending from a proximal end of the body to a distal end of the body. The inner lumen can be configured to accommodate passage of one or more elongate interventional devices therethrough. An interventional device management component can be positioned at the proximal end of the valve body. The interventional device management component can comprise a body defining a first seal member lumen configured to receive a first elongate interventional device and a second seal member lumen configured to receive a second elongate interventional device. A narrow slit configured to receive a guidewire can connect the seal member lumens.

Abstract: Devices, systems, and methods for sealing medical devices, particularly during intravascular access, are disclosed herein. Some aspects relate to a hemostatic valve for sealing a wide range of medical devices, such as catheters, wires, embolectomy systems. The valve can include an elongate member having a first end, a second end, and a central lumen extending therebetween. A reinforcement structure extends along at least a portion of the elongate member and is coupled to the elongate member. A shell defining a first aperture and a second aperture may be included, which first and second apertures can be fluidly coupled by the elongate member. A tensioning mechanism is coupled to the shell and to the elongate member, the tensioning mechanism can be moveable between a first configuration wherein the tensioning mechanism is collapsed and the central lumen is sealed and a second configuration wherein the central lumen is open.

Abstract: According to one aspect of the disclosure, a delivery device may include a handle, a catheter sheath extending distally from the handle, and a hemostasis valve positioned within the handle. The hemostasis valve may be located proximal to the catheter sheath and distal to a proximal end of the handle. The delivery device may also include a hemostasis bypass assembly coupled to the handle. The hemostasis bypass assembly may include a bypass tube coupled to an actuator. The actuator may be configured to be transitioned between a first condition in which a distal end of the bypass tube is positioned proximal to the hemostasis valve and the hemostasis valve is closed, and a second condition in which the distal end of the bypass tube traverses the hemostasis valve and the hemostasis valve is opened.

Abstract: An unloading blood pump includes a casing suitable for being incorporated into a human body, a turbine rotated by a rotor, a pumping chamber body mounted in a casing housing the turbine, an inlet port for sucking the blood from a suction cannula to the pumping chamber body and an outlet port for expelling blood from the pumping chamber to a reinjection cannula, wherein the pump is configured, depending on its power supply, to allow a nominal constant continuous flow of between 0.05 L/min and 0.5 L/min in order to reduce a capillary pressure of the lungs and/or of the left atrium and/or of the left ventricle.

Abstract: The present invention relates to a pump, in particular a blood pump having a proximal and a distal end and a pump housing arranged therebetween, a driveshaft arranged in an interior of the pump housing along the longitudinal direction, a conveying element arranged on the driveshaft, and a cannula. Here, the pump housing, the shaft arrangement and the conveying element are coordinated with one another in such a way that these guarantee the best possible efficiency and longevity of the pump.

Abstract: Disclosed herein is a pulse generator device for trigeminal nerve stimulation. In one embodiment, the pulse generator device comprises a processor(s) configured to: produce pulses delivered to an electrode assembly for a therapy session(s) for a patient, log data from the therapy session(s) (where the data comprises impedance of the electrode assembly connected to the pulse generator and current amplitude of the pulses), determine an average current amplitude from the data, determine an average therapy impedance from the data, determine a charge capacity of a battery of the pulse generator prior to beginning a subsequent therapy session, determine whether the charge capacity of the battery is sufficient to complete the subsequent therapy session for a designated duration of time by using the average current amplitude and the average therapy impedance. Further the pulse generator device comprises a display configured to display a screen comprising a graphical user interface (GUI).

Abstract: Disclosed are apparatuses and methods for reducing or limiting bleeding (e.g., blood loss and/or bleeding time) in an animal by trigeminal stimulation. The apparatuses and methods may activate one or more branches of the trigeminal nerve. This activation may be invasive or non-invasive.

Abstract: An electrode pad is an electrode pad for low-frequency therapy used in contact with a living body. The electrode pad includes a conductive material having moisture permeability and liquid permeability and a fast-drying member having insulating properties provided on a first face. The conductive material includes a first face facing the side opposite to the side where the body surface of a user is located in a contact state for the electrode pad to be in contact with the living body, and a second face facing the body surface of the user in the contact state.

Abstract: Endovascular lead design and delivery systems are described herein. One variation of an endovascular lead apparatus may generally comprise an elongate body having a proximal portion and a distal portion, one or more electrodes positioned along a first side of the distal portion, a tray positioned along a second side of the distal portion opposite to the first side, and one or more frame members positioned along the tray and which are reconfigurable from a low-profile delivery configuration to an expanded deployed configuration, wherein expansion of the one or more frame members to the expanded deployed configuration reconfigures the distal portion into contact against a tissue wall for energy delivery via the one or more electrodes.

Abstract: A relatively compact implantable medical device includes a fixation member formed by a plurality of fingers mounted around a perimeter of a distal end of a housing of the device; each finger is elastically deformable from a relaxed condition to an extended condition, to accommodate delivery of the device to a target implant site, and from the relaxed condition to a compressed condition, to accommodate wedging of the fingers between opposing tissue surfaces at the target implant site, wherein the compressed fingers hold a cardiac pacing electrode of the device in intimate tissue contact for the delivery of pacing stimulation to the site. Each fixation finger is preferably configured to prevent penetration thereof within the tissue when the fingers are compressed and wedged between the opposing tissue surfaces. The pacing electrode may be mounted on a pacing extension, which extends distally from the distal end of the device housing.

Abstract: An example fixation component for an implantable medical device (IMD) includes a base and tines extending from the base and being spaced apart from one another. The tines include a penetrator tine and a protector tine. The penetrator tine includes a curved section defining a deformable preset curvature that extends laterally from a proximal section that is fixed to the base, traversing a longitudinal axis of the fixation component, to a distal section that terminates in an incisive distal end that is configured to penetrate a tissue to form a puncture. The protector tine includes a curved section defining a deformable preset curvature that extends from a proximal section that is fixed to the base, outward from the longitudinal axis, to a distal section that terminates in a non-incisive distal end that is configured to pass through the puncture.

Abstract: A skin treatment device capable of automatically outputting high-frequency energy is proposed. The skin treatment device includes a tip configured to be in contact with skin and transmit high-frequency energy, a handpiece to which the tip may be mounted, and configured to be gripped by a user and to allow the tip to be located on the skin, and a controller configured to control output of the high-frequency energy so that the high-frequency energy may pass through the handpiece and may be transmitted through the tip, and the tip includes a temperature detecting sensor at a front surface thereof to detect temperature of the contacted skin, and the handpiece includes a pressure detecting sensor configured to detect pressure applied to the tip and an acceleration detecting sensor configured to detect acceleration input in response to movement of the handpiece.

Abstract: A hydrogel ionic circuit (HIC) electrode configured for electrical stimulation and/or drug therapy (e.g., iontophoresis) is disclosed. The HIC electrode includes a chamber containing a salt solution. The chamber is at least partially bound by a hydrogel membrane that defines a barrier for the salt solution. The HIC electrode further includes an electrode configured to apply an electrical current to the chamber to induce an ion current in the salt solution, wherein the hydrogel membrane is ionically conductive and configured to transmit the ion current.

Abstract: Provided herein are systems, methods and apparatuses for an Electronic skin rejuvenating device.

Abstract: A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and/or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and/or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal. The second electrode is in communication with the first electrode through a hardwire or wireless connection.

Abstract: A method of implanting a nerve stimulation device in treating an overactive bladder condition includes providing an external programmer and providing an implantable tibial nerve stimulation device (ITNS device) including a pulse generator enclosing circuitry and a lead coupling an electrode assembly to the pulse generator. The external programmer wirelessly communicates with the circuitry of the pulse generator to program a stimulation therapy for the ITNS device.

Abstract: Provided is a method for treating a living body using an electrical stimulator including a base wire having a core wire and an outer winding wire wound around the core wire. An annulus is formed by winding the base wire in a loop shape. A first end of the core wire is electrically connected to a first end of the outer winding wire. A second end of the core wire is connected to a first terminal of an external circuit. A second end of the outer winding wire is connected to a second terminal of the external circuit. The method includes holding the living body or a part of the living body of a subject in the annulus and generating an alternating current in the external circuit for a therapeutically effective time period to apply an electrical stimulation to the living body or the part of the living body.

Abstract: At least one electrical brain signal is received from a patient and is demultiplexed into an efferent motor intention signal and at least one afferent sensory signal (such as an afferent touch sense signal and/or an afferent proprioception signal). A functional electrical stimulation (FES) device is controlled to apply FES to control a paralyzed portion of the patient that is paralyzed due to a spinal cord injury of the patient. The controlling of the FES device is based on at least the efferent motor intention signal. A demultiplexed afferent touch sense signal may be used to control a haptic device. The afferent sensory signal(s) may be used to adjust the FES control.

Abstract: A signal processing arrangement is described for signal processing in a bilateral hearing implant system. A channel compression module develops a inhibition-adjusted band pass signal for each band pass signal using a channel-specific dynamic inhibition adjustment based on a channel-normalized medial olivocochlear reflex model that reflects bandwidth energy for a corresponding contralateral band pass signal and bandwidth energy for a selected reference contralateral band pass signal.

Abstract: Presented herein are techniques for assessing one or more outcomes associated with implantation of one or more electrodes into the inner ear of a recipient.

Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.

Abstract: Systems and methods for high frequency epidural stimulation to control sensation are disclosed herein. In one embodiment, a method for restoring physiological function in a subject having a neurological impairment includes generating a stimulation pattern. The stimulation pattern includes pulses at a first frequency, where the pulses of the stimulation pattern are modulated by a modulation pattern at a second frequency. The second frequency is higher than the first frequency. The method also includes stimulating a region of the spinal cord with the stimulation pattern via one or more electrodes.

Abstract: There is provided a stimulation device for treatment of gait impairment of a patient. The stimulation device is configured to apply respective stimulation signals to electrodes bilaterally implanted in two subcortical regions of the left and right hemispheres of the brain of the patient, the subcortical regions being associated with motor control. The stimulation device is configured to apply respective stimulation signals having a rate of electrical energy delivered that is modulated with alternating waveforms at a gait frequency and out of phase with each other.

Abstract: The present disclosure is in the field of sleep and respiratory care. In particular, the present disclosure provides means and methods for decreasing the respiratory effort of a sleeping subject. The present disclosure also provides means and methods for treating the snoring of a sleeping subject.

Abstract: The present disclosure provides systems and methods for generating burst waveforms. An implantable neurostimulation system includes an implantable stimulation lead including a plurality of contacts, and an implantable pulse generator communicatively coupled to the stimulation lead. The pulse generator is configured to generate a waveform including a burst that includes a leading anodic pulse followed by alternating cathodic pulses and anodic pulses, each cathodic pulse in the burst having a greater amplitude than the previous cathodic pulse.

Abstract: A method for optimizing stimulation for a patient having a stimulator device such as a Deep Brain Stimulation (DBS) device is disclosed. Test stimulation is provided at initial combinations of lead positions and values of a stimulation parameter such as amplitude, neural potentials are measured for each combination, and a neural response score is determined using the measured neural potentials. A next combination of position and a value of the stimulation parameter to test is determined using the neural response scores. This process repeats iteratively until a stopping criterium is met. The neural response scores and then used determine optimal therapeutic stimulation for the patient. Neural response measurements can also be used to exclude certain positions or stimulation values during subsequent optimization testing.

Abstract: Systems and methods for treating congestive heart failure with high frequency stimulation are disclosed. A representative method for treating a patient includes applying an electrical signal having a frequency of from about 1 kHz to about 100 kHz to the patient via a treatment system that includes a signal delivery element in electrical communication with the patient's vagus nerve at a portion of the vagus nerve located at or proximate to the anterior interventricular junction of the patient's heart. The method can further include automatically detecting at least one physiological parameter of the patient, automatically determining at least one of an ejection fraction of the patient's heart and a correlate of the ejection fraction based on the detected parameter, and automatically adjusting the applied signal based on the determined ejection fraction.

Abstract: An intracardiac ventricular pacemaker is configured to operate in in a selected one of an atrial-tracking ventricular pacing mode and a non-atrial tracking ventricular pacing mode. A control circuit of the pacemaker determines at least one motion signal metric from the motion signal, compares the at least one motion signal metric to pacing mode switching criteria, and, responsive to the pacing mode switching criteria being satisfied, switches from the selected one of the non-atrial tracking pacing mode and the atrial tracking pacing mode to the other one of the non-atrial tracking pacing mode and the atrial tracking pacing mode for controlling ventricular pacing pulses delivered by the pacemaker.

Abstract: A non-transitory computer-readable medium has recorded thereon a program that makes circuitry of a portable information terminal execute: a detection step of detecting presence/absence of an automated external defibrillator in an activated state based on presence/absence of a wireless signal sent from the automated external defibrillator, the wireless signal becoming detectable in response to activation of the automated external defibrillator having a wireless communication module; and a first transmission step of transmitting notification information for notification about the activation of the automated external defibrillator to a management computer in response to the automated external defibrillator in the activated state being detected in the detection step.

Abstract: A digital healthcare architecture involving a cloud-based virtual clinic platform operative to facilitate remote therapy programming for one or more patients. Upon establishing a remote programming session involving a patient and a clinician, one or more functionalities including A/V session redirection, enablement of third-party participation, remote assistance, and privacy policy control may be effectuated depending on the user input.

Abstract: Systems and methods for implantable medical devices and headers are described. In an example, an implantable medical device includes a device container including an electronic module within the device container. A modular header core includes a first core module including a first bore hole portion of a first bore hole, the first bore hole portion configured to couple a first electrical component with the electronic module. A second core module includes a second bore hole portion of a second bore hole different than the first bore hole, the second bore hole portion configured to couple a second electrical component with the electronic module. The first core module is detachably engaged with the second core module. A header shell is disposed around the modular header core and attached to the device container.

Abstract: In embodiments a WCD system is worn and/or carried by an ambulatory patient. The WCD system analyzes an ECG signal of the patient, to determine whether or not the patient should be given an electric shock to restart their heart. If so, then the WCD system first gives a preliminary alarm to the patient, asking them to prove they are alive if they are. The WCD system further determines whether the ECG signal contains too much High Amplitude (H-A) noise, which can distort the analysis of the ECG signal. If too much H-A noise is detected for a long time, the WCD system may eventually alert the patient about their activity, so that the ECG noise may be abated. The WCD system may even pause the analysis of the ECG signal, so that there will be no preliminary alarms that could be false until the ECG noise is abated.

Abstract: A Wearable Cardioverter Defibrillator (WCD) system has a processor that performs two different analyses to an ECG of the patient. A first-level analysis can be computationally economical, while a fuller second-level analysis can give shock/no-shock advice with more certainty. In some of these embodiments the second-level analysis of the ECG is performed only if the first-level analysis of the ECG detects a possible shockable condition. As such, the first-level analysis may operate as a gatekeeping function, often preventing the more computationally intensive second-level analysis from being performed. An advantage can be that the WCD system needs to store less charge, for powering the processor. In turn, this permits portions of the WCD system to be less bulky and weigh less.

Abstract: The present invention relates to a novel COVID-19 treatment system and associated method. The system features an electromagnetic field pulse generator for generating a low frequency electromagnetic field pulse configured to create a magnetic resonance with the magnetic field generated by the living coronavirus in and around a patient body of an infected person. The magnetic resonance weakens the coronavirus and expels the coronavirus from the patient body to an outside chamber wherein the chamber air is sanitized by passing through a disinfectant solution. In some embodiments, the electromagnetic field generated by the generator may include frequencies from radio frequencies to higher millimeter waves to microwaves.

Abstract: To disrupt mitochondrial function in certain cells, controlling hardware causes a magnet to oscillate so as to generate an oscillating magnetic field. The oscillating magnetic field is applied to a volume of tissue including cells with degraded mitochondria to trigger apoptosis in the cells with degraded mitochondria.

Abstract: Systems for destroying or inhibiting cancer cells and other rapidly-dividing cells including an alternating polarity (AP) magnetic field generator and at least one AP electromagnetic coil adapted to be coupled to a target body area, and a controller to control the AP magnetic field generator and at least one AP electromagnetic coil and cause the field generator and coil to apply AP magnetic field having a frequency of 0.5-500 kHz and a field strength of 0.5-5 mT to the target body area to achieve a desired inhibiting effect on cancer cells or other rapidly-dividing cells. Treatments provided by the system may be co-administered with an anti-cancer drug such as a chemotherapy drug, a hormone therapy drug, targeted therapy drugs, immunotherapy drugs, or an angiogenesis inhibitor drug.

Abstract: A soliton beam useful in influencing material in a target structure is described. Such a soliton beam can be generated suing a plasma antenna to generate an electromagnetic carrier wave, ?. The confined plasma antenna also pulses the carrier wave at a sonic frequency, f, to create a sonic wave. Pulsing the carrier wave results in a soliton beam having a sequential plurality of solitons which are separated from each other by a periodicity p, wherein ?<<p.

Abstract: A light therapy wearable includes a fabric panel and a side-emitting light tube affixed to or held against the fabric panel. The side-emitting optical light tube includes a side-emitting optical fiber and a jacket surrounding the side-emitting optical fiber. The side-emitting optical fiber includes a core and cladding surrounding the core. The core is made from a synthetic polymeric material. The jacket is made from a transparent or translucent material and has a durometer of at least 65 A and an outer diameter at least seven times a core diameter of the side-emitting optical fiber.

Abstract: A portable far infrared (FIR) radiation device containing a conductive heat producing and FIR radiation generating layer containing germanium, conductive carbon powder, a polyurethane resin, a coagulating agent, and a diluent is disclosed. Materials used for making the FIR radiation device are also disclosed.

Abstract: A light therapy wearable includes a fabric panel and a side-emitting light tube affixed to or held against the fabric panel. The side-emitting optical light tube includes a side-emitting optical fiber and a jacket surrounding the side-emitting optical fiber. The side-emitting optical fiber includes a core and cladding surrounding the core. The core is made from a synthetic polymeric material. The jacket is made from a transparent or translucent material and has a durometer of at least 50 A and an outer diameter at least seven times a core diameter of the side-emitting optical fiber.

Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.

Abstract: A radiation therapy system includes an X-ray imaging system that is configured with a combined and simplified filter and collimator positioning mechanism. In addition, an X-ray imager of the RT system is only positioned at a few discrete locations within a plane that is a fixed distance from the imaging X-ray source when generating X-ray images. As a result, for each of these discrete imaging positions, the simplified filter and collimator positioning mechanism positions a specific collimator-filter combination in a specific location between the X-ray source and the imager.

Abstract: A newly developed algorithm and software can effectively and accurately predict the collisions for the accelerator, phantom, and patient setups, and can help physicians to choose the noncolliding and optimized beam sets efficiently via offering the ideal hits of planning target volume (PTV) and constraints of organ at risks (OARs).

Abstract: A radiotherapy device can include a radiation source configured to deliver kilovolt (KV) or megavolt (MV) radiation and a detector configured to detect the delivered radiation and generate a plurality of images of a subject located between the radiation source and the detector. The radiotherapy device can further include a controller configured to detect an erroneous pixel in an image of the plurality of images and generate an averaged image. Each pixel of the averaged image can be generated by taking an average of two or more respective pixels in two or more corresponding locations of one or more of the plurality of images, and generating a pixel of the averaged image in a corresponding location to the erroneous pixel comprises excluding the erroneous pixel from the taking of the average.

Abstract: Disclosed are connector systems for power and/or data transfer in breathing apparatus. The connector systems may comprise magnetically attractive elements and magnets. The connector systems may comprise protrusions and complimentary recesses which are aligned perpendicularly to a cable axis of the connector or connectors. Also disclosed are breathing apparatus comprising the connector systems, and breathing apparatus charging systems.

Abstract: Disclosed are breathing apparatus comprising lighting systems. Lighting modules are provided to illuminate in vertical and horizontal directions and to illuminate in a first lighting pattern if the determined status condition is a normal status condition and in a second lighting pattern if the determined status condition is an alert status condition.

Abstract: Various embodiments of the teachings herein include a fiber material composite. The composite may include: a first region including metallic silver and manganese(IV) oxide for producing reactive oxygen species; and a second region configured to neutralize the reactive oxygen species.